Visible-light-enabled multicomponent synthesis of trifluoromethylated 3-indolequinoxalin-2(1H)-ones without external photocatalysis

Abstract

A novel and sustainable visible-light-enabled multicomponent reaction involving quinoxalin-2(1H)-ones, indoles, and CF₃SO₂Na that does not require an external photocatalyst is described. This photoinduced reaction employs air as the sole oxidant, thereby providing a green and highly step-efficient approach to a series of biologically important trifluoromethylated 3-indolequinoxalin-2(1H)-ones.