Green Synthesis and Catalysis最新文献

Modular trifluoromethylselenolation and fluoroalkylselenolation via Ag(I)-mediated selenium nitrogen exchange reaction of benzothiaselenazole-1-oxides Ag(I)介导苯并噻唑-1氧化物硒氮交换反应的模块化三氟甲基硒化和氟烷基硒化

Green Synthesis and Catalysis Pub Date : 2026-04-01 Epub Date: 2024-12-06 DOI: 10.1016/j.gresc.2024.12.001

Xinyue Lin, Chensi Li, Zeqin Zhuang, Chongxian Liang, Min Wu, Wei Yi, Zhi Zhou

引用次数: 0

Modulating regioselectivity of CYP107J3-catalyzed isophorone hydroxylation by disrupting the hydrophobic balance of the substrate binding pocket 通过破坏底物结合袋的疏水平衡调节 CYP107J3 催化的异佛尔酮羟基化的区域选择性

Green Synthesis and Catalysis Pub Date : 2026-04-01 Epub Date: 2024-05-31 DOI: 10.1016/j.gresc.2024.05.007

Meng Dai , Xiaojuan Yu , Xiaogang Peng , Zhiyong Guo, Huili Yu, Aitao Li

{"title":"Modulating regioselectivity of CYP107J3-catalyzed isophorone hydroxylation by disrupting the hydrophobic balance of the substrate binding pocket","authors":"Meng Dai , Xiaojuan Yu , Xiaogang Peng , Zhiyong Guo, Huili Yu, Aitao Li","doi":"10.1016/j.gresc.2024.05.007","DOIUrl":"10.1016/j.gresc.2024.05.007","url":null,"abstract":"<div><div>4-Hydroxyisophorone (4HIP) is an oxygenated intermediate derived from isophorone, serving as an important flavor and fragrance and chiral synthon of pharmaceutical drugs. In this study, a newly identified P450CYP107J3 from <em>Bacillus cereus</em> was found to prefer 4-hydroxylation of isophorone (80% regioselectivity) with 4HIP as the predominant product (59% product proportion). Bioinformatic analyses, including homologous modelling and molecular docking, reveal that four potential “hotspot” residues (L98, T300, M401 and V296) located on both sides of the substrate in the active pocket may control regioselectivity. By introducing polar residues to these hotspots to disrupt the hydrophobic balance, significant improvement in C4-regioselectivity was achieved by variants of L98, T300, and M401, with the most effective L98N exhibiting a notable enhancement of 93% C4-regioselectivity including 81% of 4HIP. Following, the double mutant L98N-M401F further improved both C4-regioselectivity (97%) and the proportion of 4HIP (86%). Remarkably, variant V296T essentially shifted regioselectivity from 4HIP to 6-hydroxyisophorone (6HIP) with an 80% preference for the latter, indicating the crucial role of V296 in controlling regioselectivity. Subsequently, the mechanism of regioselectivity of isophorone hydroxylation catalyzed by CYP107J3 was revealed by computational analysis. Furthermore, we demonstrated the generality of conserved hotspots L98 and V296 in mediating regioselectivity control in the CYP107J family members like CYP107J1 and CYP107J5. Overall, our study not only expands the biocatalytic toolbox for producing 4HIP and the <em>α</em>-hydroxy ketone 6HIP but also provides efficient engineering strategy and knowledge for the regioselectivity control of P450s in potential applications.</div></div>","PeriodicalId":12794,"journal":{"name":"Green Synthesis and Catalysis","volume":"7 2","pages":"Pages 198-204"},"PeriodicalIF":0.0,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141885091","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Regioselectively electrochemical Csp3-H alkoxylation for functionalized indanone 功能化茚酮的区域选择性电化学Csp3-H烷氧基化

Green Synthesis and Catalysis Pub Date : 2026-04-01 Epub Date: 2024-12-13 DOI: 10.1016/j.gresc.2024.12.002

Xueyang Guo , Boxuan Yao , Lirong Wen , Weisi Guo , Ming Li , Shaof Ni , Linbao Zhang

引用次数: 0

Photochemical nitrene transfer reactions of iminoiodinanes with sulfoxides 亚氨基碘烷与硫氧化物的光化学芘转移反应

Green Synthesis and Catalysis Pub Date : 2026-04-01 Epub Date: 2024-05-15 DOI: 10.1016/j.gresc.2024.05.001

Xuemei Zhao , Zhiyuan Tang , Linlin Shi , Yujing Guo , Rene M. Koenigs , Xinqi Hao

引用次数: 0

Mn2(CO)10-catalyzed direct protic hydrogen transfer with unactivated alkenes Mn2(CO)10催化非活化烯烃直接质子氢转移

Green Synthesis and Catalysis Pub Date : 2026-04-01 Epub Date: 2024-09-26 DOI: 10.1016/j.gresc.2024.09.007

Tao Li , Han Sun , Ting Shao , Albert S.C. Chan , Shan-Shui Meng

{"title":"Mn2(CO)10-catalyzed direct protic hydrogen transfer with unactivated alkenes","authors":"Tao Li , Han Sun , Ting Shao , Albert S.C. Chan , Shan-Shui Meng","doi":"10.1016/j.gresc.2024.09.007","DOIUrl":"10.1016/j.gresc.2024.09.007","url":null,"abstract":"<div><div>Transition-metal-catalyzed hydrogen-atom-transfer (HAT) reactions have proven to be effective strategies for obtaining important heterocycle scaffolds found in natural products. However, the electronic mismatch between metal catalysts and the protic hydrogen atom necessitates the use of excess oxidants and external reductive hydrogen sources in existing methods, which limit their practicality. To address this issue, we present a practical and efficient methodology for Mn₂(CO)₁₀-catalyzed intramolecular transfer of the protic hydrogen atom. A catalytic amount of <sup><em>t</em></sup>BuOOH is utilized promoting the HAT process, going beyond mere oxidation, thereby obviating the need for excess oxidants and external reductive hydrogen sources during the HAT process. Additionally, the dimeric manganese catalysis enables efficient dioxygenation, oxy-amination, oxy-sulfuration, and oxy-halogenation of alkenes. Comprehensive mechanistic studies have been done and suggest that a radical reaction pathway is involved in the proton transfer. This finding provides novel insights into the direct metal-catalyzed protic hydrogen atom-transfer reactions.</div></div>","PeriodicalId":12794,"journal":{"name":"Green Synthesis and Catalysis","volume":"7 2","pages":"Pages 205-210"},"PeriodicalIF":0.0,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147584454","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Advances in benzaldehyde lyase-catalyzed biotransformations: From enzyme engineering to industrial applications 苯甲醛裂解酶催化生物转化的研究进展：从酶工程到工业应用

Green Synthesis and Catalysis Pub Date : 2026-04-01 Epub Date: 2025-12-09 DOI: 10.1016/j.gresc.2025.12.001

Zhiyun Li , Junwei Huang , Bingrong Chen , Shilong Dou , Xiaoxia Liu , Wei Zhu , Zhiran Ju , Fener Chen

引用次数: 0

Intelligent enzyme design and hybrid catalytic systems: Driving innovation in biocatalysis 智能酶设计和混合催化系统：推动生物催化的创新

Green Synthesis and Catalysis Pub Date : 2026-04-01 Epub Date: 2025-12-09 DOI: 10.1016/j.gresc.2025.12.002

Ge Qu , Fangrui Zhong , Jian Xu , Xiaoqiang Huang , Zhoutong Sun

{"title":"Intelligent enzyme design and hybrid catalytic systems: Driving innovation in biocatalysis","authors":"Ge Qu , Fangrui Zhong , Jian Xu , Xiaoqiang Huang , Zhoutong Sun","doi":"10.1016/j.gresc.2025.12.002","DOIUrl":"10.1016/j.gresc.2025.12.002","url":null,"abstract":"<div><div>Enzyme engineering has emerged as a pivotal technology driving advances in biocatalysis, environmental remediation, and green chemistry. It is undergoing a transformative shift, propelled by the synergistic integration of artificial intelligence (AI) and innovative hybrid catalytic strategies. This review provides a comprehensive overview of recent progress in the field, emphasizing the optimization and advantages of enzyme-based catalytic systems. It examines how AI has revolutionized enzyme design, enabling unprecedented precision and efficiency. Furthermore, the integration of enzymatic catalysis with thermochemical, photochemical, and electrochemical principles is discussed, highlighting synergistic strategies that enhance reaction performance and expand application scope. Together, the convergence of AI-guided design with chemo-enzymatic, photoenzymatic, and electroenzymatic strategies is forging a new frontier in biocatalysis, offering sustainable and efficient solutions to synthetic challenges across pharmaceuticals, green chemistry, and renewable energy. Finally, the review considers the implications of these developments for sustainable industrial practices and suggests promising avenues for future research.</div></div>","PeriodicalId":12794,"journal":{"name":"Green Synthesis and Catalysis","volume":"7 2","pages":"Pages 157-174"},"PeriodicalIF":0.0,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147584816","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

N-heterocyclic nitrenium-catalyzed photoreductive radical-polar crossover for alkene dicarbofunctionalization N-Heterocyclic nitrenium-catalyzed photoreductive radical-polar crosssover for alkene dicarbofunctionalization（N-杂环腈催化光导自由基-极性交叉用于烯烃的二羧基官能化

Green Synthesis and Catalysis Pub Date : 2026-04-01 Epub Date: 2024-03-18 DOI: 10.1016/j.gresc.2024.03.002

Youfeng Han , Beibei Zhang , Zhixiang Wang , Xiangyu Chen

引用次数: 0

Visible light induced synthesis of the Benzoyl bioisosteres: bicyclo[1.1.1]pentane-ketone group 可见光诱导合成苯甲酰生物异构体：双环[1.1.1]戊烷-酮基

Green Synthesis and Catalysis Pub Date : 2026-04-01 Epub Date: 2025-03-08 DOI: 10.1016/j.gresc.2025.03.003

Jing Li , Yihui Ou , Xingyu Zhang , Xinru Li , Xin Liu , Chenguang Liu , Fener Chen

引用次数: 0

Novel biocatalyst derived from Araujia sericifera latex: Synthesis and applications 蚕丝蒿胶乳衍生的新型生物催化剂：合成与应用

Green Synthesis and Catalysis Pub Date : 2026-04-01 Epub Date: 2025-04-05 DOI: 10.1016/j.gresc.2025.03.015

Daniel Sánchez , Gabriela Tonetto , María Luján Ferreira

{"title":"Novel biocatalyst derived from Araujia sericifera latex: Synthesis and applications","authors":"Daniel Sánchez , Gabriela Tonetto , María Luján Ferreira","doi":"10.1016/j.gresc.2025.03.015","DOIUrl":"10.1016/j.gresc.2025.03.015","url":null,"abstract":"<div><div>Biocatalysts with lipase activity are increasingly required in different industrial sectors since they promote a large number of reactions with high selectivity and yield under mild conditions, promoting the development of more sustainable processes. Lipases derived from the latex of laticiferous plants are receiving increasing attention because they are easy to obtain and inexpensive. In this work, we have studied the synthesis of biocatalysts with lipase activity through the entrapment of microparticles of <em>Araujia sericifera</em> latex in a cross-linked chitosan matrix. The effect of the chitosan solution concentration (3–15 mg/ml), the cross-linking agent solution concentration (0–0.5 mol/l), the cross-linking time (0–60 min), the weight ratio latex microparticles/chitosan (1:1–3:1 wt/weight) and the pH value of the capture medium at the time of adding the latex microparticles (3–6) on the synthesis and activity of biocatalysts was studied. The performance of the entrapped microparticles synthesized under optimal conditions was evaluated in hydrolysis, esterification, and transesterification reactions with extremely promising results. This new biocatalyst showed comparable activity to Novozym 435, but its chemical and mechanical stability was considerably higher. It could be a good competitor for this prestigious commercial biocatalyst.</div></div>","PeriodicalId":12794,"journal":{"name":"Green Synthesis and Catalysis","volume":"7 2","pages":"Pages 188-197"},"PeriodicalIF":0.0,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147584817","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0