{"title":"电化学级联吡唑环化和碳氢卤化合成4-氟吡唑","authors":"Haijin Guo , Yunyun Liu , Jie-Ping Wan","doi":"10.1016/j.gresc.2023.10.004","DOIUrl":null,"url":null,"abstract":"<div><div>The synthesis of 4-halo-functionalized pyrazoles by electrochemical cascade reactions between <em>N,N</em>-dimethyl enaminones and proper hydrazine reagents in the presence of a halogen source is realized at room temperature. The work provides tunable and efficient accesses to 4-chloro- and 4-bromopyrazoles in aqueous THF (tetrahydrofuran) without using any transition metal reagent.</div></div>","PeriodicalId":12794,"journal":{"name":"Green Synthesis and Catalysis","volume":"6 2","pages":"Pages 206-210"},"PeriodicalIF":0.0000,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Electrochemical cascade pyrazole annulation and C-H halogenation for the synthesis of 4-halopyrazoles\",\"authors\":\"Haijin Guo , Yunyun Liu , Jie-Ping Wan\",\"doi\":\"10.1016/j.gresc.2023.10.004\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><div>The synthesis of 4-halo-functionalized pyrazoles by electrochemical cascade reactions between <em>N,N</em>-dimethyl enaminones and proper hydrazine reagents in the presence of a halogen source is realized at room temperature. The work provides tunable and efficient accesses to 4-chloro- and 4-bromopyrazoles in aqueous THF (tetrahydrofuran) without using any transition metal reagent.</div></div>\",\"PeriodicalId\":12794,\"journal\":{\"name\":\"Green Synthesis and Catalysis\",\"volume\":\"6 2\",\"pages\":\"Pages 206-210\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2025-05-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Green Synthesis and Catalysis\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S2666554923000820\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Green Synthesis and Catalysis","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S2666554923000820","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Electrochemical cascade pyrazole annulation and C-H halogenation for the synthesis of 4-halopyrazoles
The synthesis of 4-halo-functionalized pyrazoles by electrochemical cascade reactions between N,N-dimethyl enaminones and proper hydrazine reagents in the presence of a halogen source is realized at room temperature. The work provides tunable and efficient accesses to 4-chloro- and 4-bromopyrazoles in aqueous THF (tetrahydrofuran) without using any transition metal reagent.
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