GeroScience最新文献_第7页

Reference values for the five-times-sit-to-stand test: a pooled analysis including 45,470 participants from 14 countries. 五次坐立测试的参考值：一项汇总分析，包括来自14个国家的45470名参与者。

IF 5.4 2区医学

GeroScience Pub Date : 2025-08-28 DOI: 10.1007/s11357-025-01863-8

Jozo Grgic, Brad J Schoenfeld, Andrea B Maier, Zeljko Pedisic

{"title":"Reference values for the five-times-sit-to-stand test: a pooled analysis including 45,470 participants from 14 countries.","authors":"Jozo Grgic, Brad J Schoenfeld, Andrea B Maier, Zeljko Pedisic","doi":"10.1007/s11357-025-01863-8","DOIUrl":"https://doi.org/10.1007/s11357-025-01863-8","url":null,"abstract":"The aim of this study was to establish reference values for the Five-Times-Sit-to-Stand Test (FTSST) in a large, population-representative sample from 14 European countries. Data were collected among 45,470 participants aged 50 + years, as part of the 5th wave of the Survey of Health, Ageing and Retirement in Europe. The reference values for the FTSST were calculated as the 5th, 10th, 20th, 30th, 40th, 50th, 60th, 70th, 80th, 90th, and the 95th weighted percentile. The analyses were stratified by age and sex. For females, the best performance on the FTSST was observed among the 50-54-year-olds (5th percentile = 18 s; 50th percentile = 10 s; 95th percentile = 6 s) and the worst among 85-89-year-olds and ≥ 90-year-olds (5th percentile = 28 s; 50th percentile = 15 s; 95th percentile = 9 s). For males, the best performance was observed among the 55-59-year-olds (5th percentile = 18 s; 50th percentile = 9 s; 95th percentile = 5 s). The worst performance for males was observed among ≥ 90-year-olds (5th percentile = 26 s; 50th percentile = 15 s; 95th percentile = 9 s), even though the 10th percentile was higher (poorer performance) among 85-89-year-olds. The reference values indicate poorer performance on the test among females and in older age groups. The provided reference values for FTSST can be used for health screening, surveillance, and intervention planning, as they enable an interpretation of test results according to sex and age.","PeriodicalId":12730,"journal":{"name":"GeroScience","volume":" ","pages":""},"PeriodicalIF":5.4,"publicationDate":"2025-08-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144951567","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Five years later: no short answers for Long COVID. 五年后：长期COVID没有简短的答案。

IF 5.4 2区医学

GeroScience Pub Date : 2025-08-28 DOI: 10.1007/s11357-025-01870-9

Marc A Sala, Igor J Koralnik

引用次数: 0

History of falls in patients with atrial fibrillation and risk of major outcomes: analysis from the Prospective GLORIA-AF Registry. 房颤患者的跌倒史和主要结局的风险：来自前瞻性GLORIA-AF登记的分析

IF 5.4 2区医学

GeroScience Pub Date : 2025-08-28 DOI: 10.1007/s11357-025-01852-x

Giulio Francesco Romiti, Bernadette Corica, Tommaso Bucci, Giuseppe Boriani, Brian Olshansky, Tze-Fan Chao, Menno V Huisman, Marco Proietti, Gregory Y H Lip

{"title":"History of falls in patients with atrial fibrillation and risk of major outcomes: analysis from the Prospective GLORIA-AF Registry.","authors":"Giulio Francesco Romiti, Bernadette Corica, Tommaso Bucci, Giuseppe Boriani, Brian Olshansky, Tze-Fan Chao, Menno V Huisman, Marco Proietti, Gregory Y H Lip","doi":"10.1007/s11357-025-01852-x","DOIUrl":"https://doi.org/10.1007/s11357-025-01852-x","url":null,"abstract":"Falls pose concerns for the management and prognosis of patients with atrial fibrillation (AF). Epidemiological data on patients with AF who fall are limited. From the prospective global GLORIA-AF Registry Phase III study, we evaluated patients with a recent diagnosis of AF and CHA2DS2-VASc score ≥ 1 according to previous history of falling at baseline. We analyzed the associations with use of oral anticoagulant (OAC) and other drugs, risk of OAC discontinuation, and risk of major outcomes using multivariable regression models. Primary outcome was a composite of all-cause death and major adverse cardiovascular events (MACE); exploratory secondary outcomes were also analyzed. 20,875 patients (age 70.1 ± 10.3 years, 45.0% females) were included: 874 (4.2%) had prior falls. Patients with falls had more complex clinical profiles, were older, and were more likely female. No difference in OAC use was observed at baseline based on prior falls (OR [95%CI] 0.90 [0.75-1.08]), but patients with previous falls who received OAC were more likely treated with a NOAC compared to VKA (OR [95%CI] 1.29: 1.07-1.55) and were more likely to discontinue OAC during follow-up (HR 1.18, 95%CI 1.02-1.36). Patients with prior falls had a higher risk of the primary composite outcome (HR 1.63, 95%CI 1.40-1.90) and all secondary outcomes explored, including thromboembolism and major bleeding. Patients in the GLORIA-AF Registry with prior falls were more likely to receive a NOAC (vs. VKA) and had a higher risk of major adverse events, including all-cause mortality, thromboembolism, and major bleeding.","PeriodicalId":12730,"journal":{"name":"GeroScience","volume":" ","pages":""},"PeriodicalIF":5.4,"publicationDate":"2025-08-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144951540","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Integrative machine learning approach to risk prediction for dementia and Alzheimer's disease. 综合机器学习方法对痴呆和阿尔茨海默病的风险预测。

IF 5.4 2区医学

GeroScience Pub Date : 2025-08-27 DOI: 10.1007/s11357-025-01828-x

Amos Stern, Michal Linial

{"title":"Integrative machine learning approach to risk prediction for dementia and Alzheimer's disease.","authors":"Amos Stern, Michal Linial","doi":"10.1007/s11357-025-01828-x","DOIUrl":"https://doi.org/10.1007/s11357-025-01828-x","url":null,"abstract":"Dementia, particularly Alzheimer's disease (AD), presents a growing global health challenge characterized by cognitive decline, behavioral changes, and loss of independence. With increasing life expectancy, early diagnosis and improved clinical strategies are urgently needed. This study developed and evaluated machine learning (ML) models to predict AD risk using UK Biobank data, integrating health, genetic, and lifestyle factors. The cohort included 2878 AD cases and 72,366 controls. Among several algorithms, CatBoost performed best (ROC-AUC = 0.773), especially in females. Inputs included ICD-10 codes from 5 years pre-diagnosis, ApoE-ε4 genotype, and large collection of modifiable risk factors. Despite fewer cases, the risk predictive models for vascular dementia (VaD) outperformed the unique AD models. ApoE-ε4 was the most predictive genetic marker, while other common variants had limited utility. Key non-genetic predictors included comorbidities (e.g., diabetes, hypertension), education, physical activity, and diet. These findings highlight the value of integrating diverse data sources for dementia risk prediction and emphasize the role of sex-specific modeling and modifiable factors in early, personalized intervention strategies.","PeriodicalId":12730,"journal":{"name":"GeroScience","volume":" ","pages":""},"PeriodicalIF":5.4,"publicationDate":"2025-08-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144951575","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Sirtuins mediate the reduction of age-related oxidative damage in the cochlea under a cocoa-rich diet. 在富含可可的饮食中，Sirtuins介导耳蜗中与年龄相关的氧化损伤的减少。

IF 5.4 2区医学

GeroScience Pub Date : 2025-08-20 DOI: 10.1007/s11357-025-01847-8

Rosalía Fátima Heredia-Molina, Juan Ignacio Riestra-Ayora, Israel John Thuissard Vasallo, Ricardo Sanz-Fernández, Carolina Sánchez-Rodríguez

{"title":"Sirtuins mediate the reduction of age-related oxidative damage in the cochlea under a cocoa-rich diet.","authors":"Rosalía Fátima Heredia-Molina, Juan Ignacio Riestra-Ayora, Israel John Thuissard Vasallo, Ricardo Sanz-Fernández, Carolina Sánchez-Rodríguez","doi":"10.1007/s11357-025-01847-8","DOIUrl":"https://doi.org/10.1007/s11357-025-01847-8","url":null,"abstract":"Age-related hearing loss (ARHL) is a common condition among older adults. It has long been established that ARHL is more prevalent, is more severe, and tends to occur earlier in men than in women. A key factor contributing to ARHL is oxidative stress, which harms the inner ear cells. Sirtuins are a family of proteins that play critical roles in cellular regulation, particularly in response to stress and aging, and have demonstrated anti-aging effects. Cocoa flavonoids, due to their antioxidant properties, have been reported to provide numerous health benefits. The present study aimed to evaluate the efficacy of cocoa in preventing oxidative damage in the cochlea of aging mice mediated by Sirtuins, as well as to determine possible differences between sexes. Female and male C57Bl/6 J mice were randomly assigned to two study groups: standard diet and cocoa-supplemented diet. At the ages of 6, 14, and 22 months, the animals were sacrificed, and cochleae were harvested to measure the expression of Sirtuins-1, -3, forkhead box O3 (FOXO3), p53, antioxidant enzymes, oxidative DNA damage, and levels of reactive oxidative species (ROS). Our results indicated that cocoa attenuated oxidative DNA damage, reduced ROS levels, and induced the expression of SIRT1, -3, FOXO3, and p53 in the cochlea of aged mice. Furthermore, the activity of antioxidant enzymes in aged mice was restored with the cocoa diet. Sex differences were observed in several of these variables. These results indicate that cocoa protects against oxidative damage through Sirtuins. In conclusion, cocoa may have therapeutic potential against ARHL.","PeriodicalId":12730,"journal":{"name":"GeroScience","volume":" ","pages":""},"PeriodicalIF":5.4,"publicationDate":"2025-08-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144951543","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Different association of GDF15 and FGF21 with glycemic status and aging in the context of obesity. 肥胖背景下GDF15和FGF21与血糖状态和衰老的不同关联

IF 5.4 2区医学

GeroScience Pub Date : 2025-08-19 DOI: 10.1007/s11357-025-01830-3

Laura Salmón-Gómez, Victoria Catalán, Beatriz Ramírez, Maite Aguas-Ayesa, Amaia Rodríguez, Sara Becerril, Jorge Baixauli, Sonsoles Gutiérrez-Medina, Carmen Mugueta, Inmaculada Colina, Carolina M Perdomo, Camilo Silva, Javier Escalada, Gema Frühbeck, Javier Gómez-Ambrosi

{"title":"Different association of GDF15 and FGF21 with glycemic status and aging in the context of obesity.","authors":"Laura Salmón-Gómez, Victoria Catalán, Beatriz Ramírez, Maite Aguas-Ayesa, Amaia Rodríguez, Sara Becerril, Jorge Baixauli, Sonsoles Gutiérrez-Medina, Carmen Mugueta, Inmaculada Colina, Carolina M Perdomo, Camilo Silva, Javier Escalada, Gema Frühbeck, Javier Gómez-Ambrosi","doi":"10.1007/s11357-025-01830-3","DOIUrl":"10.1007/s11357-025-01830-3","url":null,"abstract":"Growth differentiation factor 15 (GDF15) and fibroblast growth factor 21 (FGF21) are stress-induced cytokines increased in age-related and metabolic disorders. The aim of the present study was to analyze the association between circulating concentrations of GDF15 and FGF21 in obesity and type 2 diabetes (T2D) in the context of aging. Serum samples from 405 participants (33 with normal weight and normoglycemia (NG), 156 with obesity and NG, 157 with obesity and impaired glucose tolerance (IGT), and 59 with obesity and T2D) aged 47 ± 13 years, were recruited to study the serum GDF15 and FGF21 concentrations and their relationship with obesity, T2D, and aging. Adipokines (leptin and adiponectin) and other cardiometabolic risk factors were also measured. The circulating concentrations of GDF15 and FGF21 were significantly increased with obesity and further increased with IGT and T2D. Both GDF15 and FGF21 showed positive associations with glucose (r = 0.25, P < 0.001 and r = 0.40, P < 0.001, respectively) and insulin (r = 0.16, P < 0.01 and r = 0.27, P < 0.001, respectively) levels. Similarly, GDF15 and FGF21 were positively correlated with age (r = 0.55, P < 0.001 and r = 0.15, P < 0.01, respectively). Interestingly, the FGF21/adiponectin and GDF15/adiponectin ratios emerged as good biomarkers for the presence of T2D (AUC = 0.807 and 0.779, respectively). Our findings support that obesity, T2D, and aging increase the concentrations of both GDF15 and FGF21. Furthermore, GDF15 concentrations are more associated with aging while FGF21 levels are more related to the metabolic status. Finally, we propose the FGF21/adiponectin ratio as a novel biomarker for the detection of the presence of T2D.","PeriodicalId":12730,"journal":{"name":"GeroScience","volume":" ","pages":""},"PeriodicalIF":5.4,"publicationDate":"2025-08-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144872908","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effects of resistance-based training and polyphenol supplementation on physical function, metabolism, and inflammation in aging individuals. 抗阻训练和多酚补充对衰老个体身体功能、代谢和炎症的影响。

IF 5.4 2区医学

GeroScience Pub Date : 2025-08-19 DOI: 10.1007/s11357-025-01839-8

Mathias Flensted-Jensen, Cecilie Moe Weinreich, Ann-Sofie Kleis-Olsen, Filip Hansen, Nadia Stenner Skyggelund, Jeppe Rahbek Pii, Ryan Whitlock, Marie-Louise Brødsgaard Abrahamsen, Thomas Isbrandt Petersen, Anders Karlsen, Dace Reihmane, Flemming Dela

{"title":"Effects of resistance-based training and polyphenol supplementation on physical function, metabolism, and inflammation in aging individuals.","authors":"Mathias Flensted-Jensen, Cecilie Moe Weinreich, Ann-Sofie Kleis-Olsen, Filip Hansen, Nadia Stenner Skyggelund, Jeppe Rahbek Pii, Ryan Whitlock, Marie-Louise Brødsgaard Abrahamsen, Thomas Isbrandt Petersen, Anders Karlsen, Dace Reihmane, Flemming Dela","doi":"10.1007/s11357-025-01839-8","DOIUrl":"10.1007/s11357-025-01839-8","url":null,"abstract":"Aging is associated with declines in muscle mass, strength, aerobic capacity, and metabolic health, accompanied by increased low-grade inflammation. The purpose of this study was to assess the effects of 12 weeks of resistance training (RT) combined with minimal high-intensity interval training (HIIT), with or without polyphenol supplementation, on muscular, cardiovascular, metabolic, and inflammatory adaptations in healthy older adults. Forty-one men and women aged 55-70 years ingested either polyphenol supplementation or placebo for 30 days, then underwent 12 weeks of supervised RT combined with once-weekly HIIT, continuing polyphenol supplementation or placebo throughout. The training intervention increased whole-body and thigh lean mass, vastus lateralis cross-sectional area, type II fiber size, and muscle and functional strength (all p < 0.001). Maximal oxygen uptake significantly increased (p = 0.0001), accompanied by reductions in heart rate and plasma lactate during submaximal exercise, as well as increases in total blood volume and hemoglobin mass (p < 0.05). Training led to reductions in respiratory exchange ratio and plasma cortisol during exercise, which, together with decreased cholesterol levels and trends toward increased peak fat oxidation, may suggest enhanced substrate utilization. Polyphenols alone lowered cholesterol levels but had no other effects. Although no changes were observed in basal systemic or muscle inflammation, the exercise intervention attenuated the acute exercise-induced inflammatory responses of IL-10, IFN-γ, and TNF-α (p < 0.05). These results indicate that a combined RT and minimal HIIT program improves muscular, aerobic, and metabolic health, and may improve inflammatory regulation in aging adults.","PeriodicalId":12730,"journal":{"name":"GeroScience","volume":" ","pages":""},"PeriodicalIF":5.4,"publicationDate":"2025-08-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144882772","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A prospective study on the regulation of osteoarthritis risk through inflammatory pathways in clonal hematopoiesis. 克隆造血中炎症途径对骨关节炎风险调节的前瞻性研究。

IF 5.4 2区医学

GeroScience Pub Date : 2025-08-19 DOI: 10.1007/s11357-025-01843-y

Ping Li, Zijian Kang, Ruiqi Ma, Chen Zhu, Ying Zhu, Iris Tang, Jianzheng Zhang, Kai Li, Qiang Tong

{"title":"A prospective study on the regulation of osteoarthritis risk through inflammatory pathways in clonal hematopoiesis.","authors":"Ping Li, Zijian Kang, Ruiqi Ma, Chen Zhu, Ying Zhu, Iris Tang, Jianzheng Zhang, Kai Li, Qiang Tong","doi":"10.1007/s11357-025-01843-y","DOIUrl":"10.1007/s11357-025-01843-y","url":null,"abstract":"Osteoarthritis (OA) is a common degenerative joint disease characterized by articular cartilage degeneration, joint inflammation, and bone hyperplasia. Clonal hematopoiesis of indeterminate potential (CHIP) refers to the presence of cancer-related variants in blood cells of individuals without malignancies. However, it is unclear whether the proinflammatory state induced by CHIP affects the onset of OA. Thus, we investigated CHIP as a risk factor for OA. Here, we analyzed whole-exome sequence (WES) data from 45,380 UK Biobank participants without OA at baseline to identify CHIP. Multivariate Cox regression models were used to evaluate the association between CHIP and incident OA as well as different sites of OA onset. Additionally, enrichment and mediation analyses were conducted on 1463 unique protein datasets to identify protein markers and biological pathways related to both CHIP and OA. We found that the incidence of OA was higher in individuals with CHIP than in those without CHIP. Importantly, individuals with CHIP and VAF > 10% had an increased risk of OA (hazard ratio [HR], 1.46; 95% CI, 1.28-1.68; P < 0.001). The results of classification of OA sites showed that polyarticular OA and hip OA were most significantly associated with CHIP. In addition, analysis of OA and CHIP-related expression proteins and pathways revealed that both were mainly involved in extracellular matrix organization, inflammation, and metabolic pathways. Moreover, the proteomic analysis results suggested that CHIP may influence the occurrence of OA by affecting seven proteins: CD5, CD79B, CEACAM1, FOLR2, LILRA5, SIRPB1, and TXNDC15. CHIP is significantly associated with the risk of incident OA and may exacerbate the progression of OA through inflammatory and immune response mechanisms. This research provides new insights into the pathogenesis of OA, offering a theoretical basis for the early prevention of OA, although a causal relationship remains to be investigated.","PeriodicalId":12730,"journal":{"name":"GeroScience","volume":" ","pages":""},"PeriodicalIF":5.4,"publicationDate":"2025-08-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144882771","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Patterns of transcriptomic aging in the hippocampus of rhesus macaques highlight midlife transitions. 恒河猴海马的转录组老化模式突出了中年过渡。

IF 5.4 2区医学

GeroScience Pub Date : 2025-08-18 DOI: 10.1007/s11357-025-01834-z

Tanner J Anderson, Marina M Watowich, Kenneth L Chiou, Elisabeth A Goldman, Sam Peterson, Jordan A Anderson, Noah Snyder-Mackler, Lucia Carbone, Steven G Kohama, Kirstin N Sterner

{"title":"Patterns of transcriptomic aging in the hippocampus of rhesus macaques highlight midlife transitions.","authors":"Tanner J Anderson, Marina M Watowich, Kenneth L Chiou, Elisabeth A Goldman, Sam Peterson, Jordan A Anderson, Noah Snyder-Mackler, Lucia Carbone, Steven G Kohama, Kirstin N Sterner","doi":"10.1007/s11357-025-01834-z","DOIUrl":"10.1007/s11357-025-01834-z","url":null,"abstract":"Patterns of brain aging are generally conserved among primates; however, there is marked variation in the observed rate among individuals, species, and brain regions. The hippocampus is a region particularly susceptible to the aging process. To better understand how the hippocampus changes over the lifespan, we measured gene expression in 96 banked hippocampus samples from adult male and female rhesus macaques aged 3-35 years old. Importantly, our dataset included representation across adulthood allowing us to characterize age-related patterns in gene expression during midlife, a period often underrepresented in studies of aging. We used autoregressive integrated moving average models to examine age-associated changes in gene expression to identify 2679 differentially expressed genes (FDR < 0.05) that fit four broad patterns of expression: linearly upregulated or downregulated across age, and two clusters with nonlinear patterns. Importantly, the nonlinear clusters highlight transitions in expression trajectories centered around ~ 10 years of age (~ 30 years of age in humans) indicating an important period that may have a critical impact on hippocampal aging. Changes in gene expression variance across age found that genes in individuals > 20 years of age (> 50 years of age in humans) have greater variance in expression than individuals aged 10-20 years (FDR < 0.05). Collectively, our results highlight molecular changes occurring during midlife which may shape brain aging in longer lived primates and may offer insight into increased susceptibility to neurodegenerative disease in humans.","PeriodicalId":12730,"journal":{"name":"GeroScience","volume":" ","pages":""},"PeriodicalIF":5.4,"publicationDate":"2025-08-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144872909","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

BrainAGE in superagers: cross-sectional and longitudinal analyses in older adults aged 80+ with youthful episodic memory. 超级老年人的脑龄：80岁以上具有年轻情景记忆的老年人的横断面和纵向分析。

IF 5.6 2区医学

GeroScience Pub Date : 2025-08-16 DOI: 10.1007/s11357-025-01836-x

Christian Gaser,Marta Garo-Pascual,Bryan A Strange

{"title":"BrainAGE in superagers: cross-sectional and longitudinal analyses in older adults aged 80+ with youthful episodic memory.","authors":"Christian Gaser,Marta Garo-Pascual,Bryan A Strange","doi":"10.1007/s11357-025-01836-x","DOIUrl":"https://doi.org/10.1007/s11357-025-01836-x","url":null,"abstract":"Episodic memory, the ability to recall past events, is particularly vulnerable to ageing. A decline in episodic memory performance is generally considered part of ageing. However, the episodic memory performance of superagers -defined as individuals aged 80+ years old with episodic memory of people 30 years younger- is superior to that typical of their chronological age. The aim of this study was to determine whether the discrepancy between the superager's episodic memory and chronological age is also evident in their brain age. A BrainAGE (Brain Age Gap Estimation) approach, a multidimensional computational neuroanatomical method that uses structural neuroimaging data to estimate biological brain age, was applied. The study population comprised 64 superagers (mean age = 81.9 ± 1.9) and 55 age-matched typical older adults (82.4 ± 1.9). Cross-sectional analyses revealed a negative BrainAGE score for superagers (mean = -0.95 ± 2.36) indicating a deceleration of the ageing process. By contrast, typical older adults showed an average score close to zero (0.05 ± 3.03) consistent with their chronological age. The BrainAGE score of superagers was found to be lower relative to typical older adults, and the progression over a 5-year follow-up period was slower in superagers, in keeping with their youthful memory ability. Therefore, superagers have a younger brain than those of typical older adults, suggesting that their ageing mechanisms may involve resistance to age-related brain structural changes. However, despite a 30-year gap in episodic memory, their BrainAGE score differed by only one year, indicating that factors beyond brain structure contribute to the superager phenotype.","PeriodicalId":12730,"journal":{"name":"GeroScience","volume":"15 1","pages":""},"PeriodicalIF":5.6,"publicationDate":"2025-08-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144857714","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0