GeroScience最新文献

{"title":"Quantitative assessment of asymptomatic spinal cord compression using MRI: a multi-center study.","authors":"Ali F Khan,Sanaa Hameed,Alaa Baha,Fauziyya Muhammad,Grace Haynes,Amber Dastgir,Suresh K Gulla,Hakeem J Shakir,Michael L Rohan,Yasin Y Dhaher,Zachary A Smith","doi":"10.1007/s11357-025-01837-w","DOIUrl":"https://doi.org/10.1007/s11357-025-01837-w","url":null,"abstract":"Aging is associated with an increased risk of neurodegenerative conditions, including degenerative cervical myelopathy (DCM), a leading cause of neurological disability in older adults. Asymptomatic spinal cord compression (ASCC) represents a potential precursor to DCM, characterized by spinal cord compression in individuals without overt clinical symptoms. Early identification and quantification of ASCC are critical for preventing age-related neurological decline. However, a standardized quantitative definition of ASCC remains lacking. This study aimed to develop a quantitative approach to assess cervical ASCC using high-resolution magnetic resonance imaging (MRI). T2-weighted 3 T spine MRI scans from 248 healthy controls (HCs), 53 ASCC individuals, and 55 DCM patients from three datasets conforming to the spine generic protocol were analyzed. An automated pipeline utilizing the Spinal Cord Toolbox was used to compute the maximum spinal cord compression (MSCC) metric at each slice, with peak MSCC serving as a quantitative metric for spinal cord compression. ASCC was identified in 17.6% of participants, predominantly at the C4-C6 spinal levels. While ASCC was observed in younger individuals (median age = 36 years), its prevalence increased with age. DCM patients were significantly older (median age = 54 years), exhibiting greater peak MSCC (22.4%) than ASCC individuals (13.8%). These findings suggest that spinal cord compression may begin in midlife and progress with aging, potentially contributing to age-related neurological impairments. This study validates an automated MRI-based approach for detecting and quantifying spinal cord compression, enabling large-scale analysis in aging populations. Given that ASCC is more common in older adults, longitudinal studies are necessary to determine its progression and potential conversion to symptomatic DCM. The proposed quantitative method may aid in early detection and monitoring of spinal cord compression, informing clinical decision-making to mitigate neurological decline in aging individuals.","PeriodicalId":12730,"journal":{"name":"GeroScience","volume":"19 1","pages":""},"PeriodicalIF":5.6,"publicationDate":"2025-08-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144851052","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Lower diet quality accelerates DNA methylation-based age.","authors":"Botong Shen,Nicole Noren Hooten,Nicolle A Mode,Marie Fanelli Kuczmarski,Alan B Zonderman,Michele K Evans","doi":"10.1007/s11357-025-01835-y","DOIUrl":"https://doi.org/10.1007/s11357-025-01835-y","url":null,"abstract":"A new DNA methylation biomarker, Dunedin Pace of Aging Calculated from the Epigenome (DunedinPACE), is associated with healthy lifespan in several European ancestry cohorts. Few studies have examined the relation between dietary quality and DunedinPACE in African American and White adults with longitudinal assessments. To assess the relationship between diet quality and DunedinPACE, we used longitudinal data from African American and White 30-64 year old adults living above and below poverty. Participants' DunedinPACE scores and dietary assessments were calculated at two time points, approximately 5 years apart. Numbers of participants (n = 421; mean age 49 years) were balanced by race, sex, and poverty status. Diet quality was assessed using two different dietary indexes: Dietary Inflammatory Index (DII) and Healthy Eating Index-2010 (HEI). Linear mixed model regression examined the longitudinal association of DunedinPACE with DII and HEI adjusted by age, race, poverty status, BMI, and smoking status. Initial mean values of DII were 3.34 (SD = 2.16) and HEI was 40.67 (SD = 11.69), indicating a pro-inflammatory dietary pattern and low diet quality in this cohort. The initial mean DunedinPACE score was 1.07. We found that a higher DII score was associated with higher DunedinPACE score (β = 0.009; p < 0.001), higher HEI score was associated with lower DunedinPACE score (β =  - 0.001; p = 0.032), and that these relationships were consistent over time. Overall, lower dietary quality was associated with a faster pace of aging captured by DunedinPACE score. Our findings demonstrate the independent contribution of diet quality to healthy aging-related epigenetic mechanisms.","PeriodicalId":12730,"journal":{"name":"GeroScience","volume":"31 1","pages":""},"PeriodicalIF":5.6,"publicationDate":"2025-08-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144857715","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Muscle-brain crosstalk as a driver of brain health in aging.","authors":"B L McNeish,I Miljkovic,T Liu-Ambrose,F Ambrosio,K Esser,M Fahnestock,C Rosano","doi":"10.1007/s11357-025-01833-0","DOIUrl":"https://doi.org/10.1007/s11357-025-01833-0","url":null,"abstract":"Cognitive impairment and dementia in older adults represent significant global health challenges. Although the bidirectional relationship between physical function and brain health is well established, the mechanistic drivers of this link remain poorly understood. Muscle function and quality are central to physical function, and muscle's secretome is increasingly recognized for its systemic health effects-supporting the potential for muscle-to-brain crosstalk. This concept was explored at the 3rd International Research Symposium on Brain Health, jointly hosted by Vancouver Coastal Health and the University of British Columbia. We present the findings of this symposium, which reviewed the current state of the literature on muscle-to-brain crosstalk from multiple perspectives, spanning population studies to preclinical models. A key focus was the muscle secretome, particularly myokines and extracellular vesicles, as potential messengers influencing brain health. The symposium also identified critical takeaways and proposed next steps to further elucidate the underlying mechanisms of muscle-to-brain crosstalk and explore how these pathways might be harnessed through exercise or pharmacologic interventions to promote brain health in older adults.","PeriodicalId":12730,"journal":{"name":"GeroScience","volume":"9 1","pages":""},"PeriodicalIF":5.6,"publicationDate":"2025-08-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144850934","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mitochondrial bioenergetics in resilience of older adults with gynecologic cancer: design and rationale of a pilot study.","authors":"Anna Kuan-Celarier, Michelle L Wallander, Jennifer Hartzell, Brittany Lees, Xiaoyan Iris Leng, Philip A Kramer, Nicholas J Day, Wei-Jun Qian, Bumsoo Ahn","doi":"10.1007/s11357-025-01823-2","DOIUrl":"10.1007/s11357-025-01823-2","url":null,"abstract":"<p><p>Resilience-the ability to recover and maintain function following stresses-is a critical factor influencing treatment tolerance and recovery in older adults with cancer. Despite the high incidence of gynecologic cancers in postmenopausal individuals, resilience in this population remains underexplored, even though patients commonly face compounded stress from both chemotherapy and surgery. The goal of our research is (1) to test the feasibility of cognitive and physical function assessments in older women with gynecologic cancers and (2) to discover reliable predictors that enhance clinical decision-making and guide personalized treatment strategies. Current clinical assessments focus on isolated physiological systems. As such, there is a need for a reliable predictor that captures systemic resilience more comprehensively. A reliable predictor of resilience following cancer treatment could improve clinical decision-making and identify potential targets for therapeutic intervention. Both mitochondrial bioenergetics and oxidative stress are presumably mechanistically linked to resilience of patients with gynecologic cancers because of widely known effects of chemotherapy and tumor burden on mitochondrial bioenergetics. Mitochondria generate more than 95% of cellular ATP through oxidative phosphorylation, a process essential for recovery following physiological stress. Oxidative stress disrupts excitation-contraction coupling and reduces metabolic efficiency in skeletal muscle, contributing to weakness and fatigue. In the brain, oxidative modifications have been associated with impaired neurotransmission and cognitive dysfunction. This protocol paper describes a longitudinal study design aimed at evaluating the feasibility of resilience assessment and testing mitochondria and oxidative stress as predictors of resilience in older adults diagnosed with advanced endometrial or ovarian cancer.</p>","PeriodicalId":12730,"journal":{"name":"GeroScience","volume":" ","pages":""},"PeriodicalIF":5.4,"publicationDate":"2025-08-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144855019","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The University of Oklahoma Inpatient Spine Protocol: optimizing surgical outcomes through standardized perioperative care.","authors":"David Barkyoumb, William C Kaiser, Lonnie Smith, Lance M Villeneuve, Graham Mulvaney, Chao Li, Christopher S Graffeo, Andrew M Bauer, Hakeem J Shakir, Karl Balsara, M Burhan Janjua, John F Burke, Andrew Jea, Zachary A Smith","doi":"10.1007/s11357-025-01826-z","DOIUrl":"https://doi.org/10.1007/s11357-025-01826-z","url":null,"abstract":"<p><p>Standardized care delivery protocols have demonstrated substantial benefits across a range of surgical subspecialties, with growing evidence supporting their application to elective spinal surgery. At our institution, we have developed and implemented a comprehensive spine surgery protocol that spans both the ambulatory and inpatient phases of care. In this manuscript, we focus on our inpatient protocol, which incorporates a standardized checklist designed to reduce surgical morbidity and enhance patient outcomes. Key areas of focus include mitigation of surgical site infections, wound complications, decreasing opioid use and dependency, and accelerating functional recovery. Each intervention has been selected and is based upon evidence from the literature, clinical relevance, and feasibility, and is applied systematically across each phase of care: pre-incision, intraoperative, and postoperative phases. While the protocol is currently being piloted among high-risk patients, it is designed for future scalability and institution-wide integration. Importantly, although focused on the inpatient surgical episode, this portion of the protocol's benefits extends beyond hospitalization. By targeting the modifiable risk factors most closely associated with postoperative complications and readmissions, this protocol has the potential to reduce healthcare utilization and improve long-term outcomes. In doing so, it contributes meaningfully to the growing body of literature supporting standardized care protocols as a critical tool in delivering high-value, outcome-driven spine care.</p>","PeriodicalId":12730,"journal":{"name":"GeroScience","volume":" ","pages":""},"PeriodicalIF":5.4,"publicationDate":"2025-08-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144845627","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Analysis of variability and epigenetic age prediction across microarray and methylation sequencing technologies.","authors":"Maxim N Shokhirev,Adiv A Johnson","doi":"10.1007/s11357-025-01824-1","DOIUrl":"https://doi.org/10.1007/s11357-025-01824-1","url":null,"abstract":"Using 100 technical replicate samples from two adult buccal cohorts, we compared technical methylation variability and signal strength between the Infinium MethylationEPIC v2.0 array and the Twist Human Methylome Panel across 753,648 shared CpGs. Twist methylation sequencing showed skewed methylation distributions and fewer highly correlated CpGs than MethylationEPIC arrays. Variance analysis revealed a skew toward higher signal strength in MethylationEPIC datasets, with a subset of CpGs showing high signal strength in both methylation sequencing and array datasets. Despite these biases, four principal component (PC) trained epigenetic clocks (pcHorvath1, pcHorvath2, pcHannum, and pcDNAm PhenoAge) were robust across both technologies, even with missing data. While pcHannum and pcDNAm PhenoAge were similarly reproducible with mean absolute replicate difference (MRD) values ranging from 1.014 years to 1.194 years, pcHorvath1 was more reproducible in arrays (MRD = 0.459 years) than methylation sequencing (MRD = 2.320 years) and pcHorvath2 was more reproducible in methylation sequencing (MRD = 0.760 years) than arrays (MRD = 1.011 years). Furthermore, original non-PC versions of these clocks were less reproducible in Twist datasets and, as an example of this, MRD for uncorrected clocks went as high as 15.498 years in arrays and as high as 20.180 years in methylation sequencing. Obvious differences in age prediction were also observed in original clocks compared to their PC-trained versions across both technologies (with a mean absolute difference ranging from 4.492 years to 46.724 years). This underscores the need for careful selection of epigenetic clocks and technology-specific adjustments when optimizing for accuracy and reproducibility.","PeriodicalId":12730,"journal":{"name":"GeroScience","volume":"15 1","pages":""},"PeriodicalIF":5.6,"publicationDate":"2025-08-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144813170","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Quantifying placebo and trial participation effects on cognitive outcome measures in aging dogs.","authors":"Katherine E Simon,Katharine Russell,Alejandra Mondino,Chin-Chieh Yang,Beth C Case,Zachary Anderson,Christine Whitley,Emily Griffith,Margaret E Gruen,Natasha J Olby","doi":"10.1007/s11357-025-01822-3","DOIUrl":"https://doi.org/10.1007/s11357-025-01822-3","url":null,"abstract":"The placebo effect, or the positive effects observed after an inert treatment which result from patients' expectations for the therapy, is well documented in human medicine. However, in veterinary medicine, where owner's expectations serve as a proxy for their pets, it remains underexplored, particularly for elderly dogs with cognitive decline. To address this gap, we examined 21 dogs (mean age: 12.85 years, SD: 1.46) from a placebo group in a randomized controlled trial (RCT) and compared their results to 17 dogs (mean age: 13.24 years, SD:1.56) from an observational, longitudinal study to distinguish placebo effect from trial participation effect. Both populations had statistically comparable baseline data. Cognitive changes were evaluated with two remotely administered owner questionnaires (Canine Cognitive Dysfunction Scale (CCDR) and Canine Dementia Scale (CADES)) and three in-house cognitive assessments (Cylinder Task, Detour and Sustained Gaze). We hypothesized that placebo effect would be greater than trial participation effect, particularly in owner-reported measures. Matched pairs T-tests and effect size calculations (Hedge's g) were used to calculate changes across 6 months. A strong (g = 0.76), significant (p = 0.021) improvement in CADES was observed in the placebo cohort after 6 months, while no changes were detected with CCDR. Conversely, the observational cohort showed a small (g = 0.35) and significant (p = 0.03) deterioration on CCDR, and no change in CADES. No significant changes were noted on the in-house cognitive assessments in either cohort. We conclude that study context influences remotely delivered owner assessments and CCDR is more robust against caregiver placebo effect in RCTs than CADES.","PeriodicalId":12730,"journal":{"name":"GeroScience","volume":"37 1","pages":""},"PeriodicalIF":5.6,"publicationDate":"2025-08-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144819826","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Epigenetic dysregulation of transposable elements in cognitive impairment and Alzheimer's disease.","authors":"Alyssa N Cavalier,Meghan E Smith,Gabriella T McWilliams,Cali M McEntee,Brianne M Bettcher,Christina Coughlan,Thomas J LaRocca","doi":"10.1007/s11357-025-01765-9","DOIUrl":"https://doi.org/10.1007/s11357-025-01765-9","url":null,"abstract":"Aging and cognitive impairment increase the risk for Alzheimer's disease (AD), and growing evidence suggests that transposable elements (TEs) in the genome play a role in aging and AD. The mechanisms of TE dysregulation in this context are unclear, but one possibility is that epigenetic changes, including DNA hypomethylation and/or reduced chromatin structure, underlie age- and AD-related TE activity. Therefore, the purpose of the present study was to generate a resource for studying TE epigenetics in aging and AD, and to use it to determine if epigenetically dysregulated TEs are related to age/AD-relevant clinical outcomes. We performed RNA-seq on peripheral blood samples from 45 healthy older adults, mild cognitive impairment (MCI) and AD dementia patients, and we observed a pattern of undulating TE transcript expression with MCI and AD, similar to previous reports. We then used whole-genome bisulfite sequencing (WGBS) and transposase-accessible chromatin sequencing (ATAC-seq) to characterize global DNA methylation and chromatin accessibility in the same subjects. We found that most TEs that were enriched/dysregulated in our RNA-seq data with MCI and AD could be found within hypomethylated and chromatin-accessible regions of the genome. These TEs included several that have been directly linked to inflammation and disease in humans, and they were related to cognitive/functional diagnosis, age, and biomarkers of inflammation and neurodegeneration in the subjects we studied. Collectively, these findings are consistent with the idea that epigenetic alterations may contribute to TE transcript dysregulation that plays an important role in aging, cognitive decline, and AD.","PeriodicalId":12730,"journal":{"name":"GeroScience","volume":"1 1","pages":""},"PeriodicalIF":5.6,"publicationDate":"2025-08-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144797108","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between weight-adjusted waist index and cardiometabolic multimorbidity in older adults: Findings from the English Longitudinal Study of Ageing.","authors":"Setor K Kunutsor,Sae Young Jae,Jari A Laukkanen","doi":"10.1007/s11357-025-01829-w","DOIUrl":"https://doi.org/10.1007/s11357-025-01829-w","url":null,"abstract":"The weight-adjusted waist index (WWI) is a novel anthropometric measure designed to better reflect central obesity than traditional indices such as body mass index and waist circumference (WC). This study examined the prospective association between WWI and cardiometabolic multimorbidity (CMM) and evaluated its predictive utility. We included 3,348 participants (mean age 63 years; 45.1% male) from the English Longitudinal Study of Ageing who were free from hypertension, coronary heart disease, diabetes, and stroke at baseline (wave 4: 2008-2009). WWI was calculated as WC (cm) divided by the square root of body weight (kg). CMM was defined as the presence of ≥ 2 of the following conditions at wave 10 (2021-2023): hypertension, cardiovascular disease, diabetes, or stroke. Multivariable logistic regression and measures of discrimination were used to assess associations and predictive value. Over 15 years, 197 participants developed CMM. Restricted cubic spline analysis indicated a linear dose-response relationship between WWI and CMM risk (p for nonlinearity = .44). Each 1 SD increase in WWI was associated with higher odds of CMM (odds ratio, OR = 1.30; 95% CI: 1.12-1.51), persisting after adjustment for physical activity (OR = 1.28; 95% CI: 1.10-1.49). Similar associations were observed across WWI tertiles. Adding WWI to conventional risk models slightly improved discrimination (ΔC-index = 0.0065; p = .29), with a significant improvement in model fit (-2 log likelihood, p = .001). Higher WWI levels were independently and linearly associated with increased CMM risk in older adults. WWI also improved CMM risk prediction beyond conventional risk factors.","PeriodicalId":12730,"journal":{"name":"GeroScience","volume":"16 1","pages":""},"PeriodicalIF":5.6,"publicationDate":"2025-08-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144796776","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nicotinamide riboside combined with exercise to treat hypertension in middle-aged and older adults: a pilot randomized clinical trial.","authors":"Yi Lin,Rola S Zeidan,Stephanie Lapierre-Nguyen,Hannah M Costello,Stephen D Anton,Thomas W Buford,Demetra D Christou,Michelle L Gumz,Christiaan Leeuwenburgh,Christopher R Martens,Mary M McDermott,Marie E Migaud,Bhanuprasad Sandesara,Douglas R Seals,Peihua Qiu,Yipeng Wang,Robert T Mankowski","doi":"10.1007/s11357-025-01815-2","DOIUrl":"https://doi.org/10.1007/s11357-025-01815-2","url":null,"abstract":"Aerobic exercise lowers blood pressure (BP) with varying effects in hypertensive adults, potentially due to age-related nicotinamide adenine dinucleotide (NAD) metabolism dysregulation. This pilot randomized clinical trial (RCT) tested the efficacy of combining aerobic exercise with the NAD booster nicotinamide riboside (NR) to enhance BP control. In this double-blinded RCT, 54 sedentary adults (≥ 55 years) with mean daytime systolic BP (SBP) ≥ 130 mmHg were randomized to 6 weeks of 1000 mg/day of NR combined with 3 days/week of supervised 30-min walking exercise (NR + Ex), Placebo combined with the same exercise regimen (PL + Ex), or NR alone (NR). The primary outcome was daytime SBP. Other outcomes included pulse wave velocity (PWV), NAD catabolites, and nighttime BP. The primary comparison was between NR + Ex and PL + Ex. Of 54 participants (mean age 67 years, 61% female), 49 (NR + Ex: n = 15, PL + Ex: n = 16, NR: n = 18) completed all study visits (93% adherence to exercise and 90% to supplementation). NR + Ex (mean change = 5.19 ± 13.2 mmHg) did not reduce SBP more than PL + Ex (- 2.71 ± 10.5 mmHg). NR + Ex (- 0.31 ± 0.77 m/s) showed a trend toward a greater reduction in PWV. Levels of NAD catabolites were higher in NR groups. In a post hoc analysis, NR + Ex showed a trend toward greater nighttime BP reductions (systolic: - 9.6 ± 9.22; diastolic: - 4.51 ± 7.12 mmHg) in participants without antihypertensive medications. NR + Ex was not superior to PL + Ex in reducing BP in hypertensive middle-aged and older. However, trends toward greater nighttime BP reduction in NR + Ex in participants without antihypertensive medication warrant further investigation in a Phase IIb RCT.","PeriodicalId":12730,"journal":{"name":"GeroScience","volume":"31 1","pages":""},"PeriodicalIF":5.6,"publicationDate":"2025-08-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144791994","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}