GeroScience最新文献_第9页

Brain care score and retinal health: structural and metabolic insights from the UK Biobank. 脑保健评分和视网膜健康：来自英国生物银行的结构和代谢见解。

IF 6 2区医学

GeroScience Pub Date : 2026-10-09 DOI: 10.1007/s11357-026-02579-z

Jun Yu, Yuzhou Zhang, Yue Lan Gao, Mary Ho, Ka Wai Kam, Bo Gong, Alvin L Young, Chi Pui Pang, Clement C Tham, Jason C Yam, Li Jia Chen

{"title":"Brain care score and retinal health: structural and metabolic insights from the UK Biobank.","authors":"Jun Yu, Yuzhou Zhang, Yue Lan Gao, Mary Ho, Ka Wai Kam, Bo Gong, Alvin L Young, Chi Pui Pang, Clement C Tham, Jason C Yam, Li Jia Chen","doi":"10.1007/s11357-026-02579-z","DOIUrl":"https://doi.org/10.1007/s11357-026-02579-z","url":null,"abstract":"The retina is an extension of the central nervous system and a recognized indicator of systemic health, yet the link between the brain care score (BCS) and retinal health remains unclear. In this study, we aimed to assess the associations of BCS with retinal layer thickness and retinal biological age and to evaluate potential metabolic mediation for retinal thickness. A total of 28,657 UK Biobank participants with optical coherence tomography (OCT) imaging at baseline were included, of whom 14,656 had metabolomic data. We constructed a 19-point BCS incorporating physical, lifestyle, and social-emotional domains, with higher scores indicating better brain care. Eight retinal layers and overall macular thickness were assessed. Retinal aging was evaluated using the OCT age gap, defined as the difference between the retinal age predicted by a support vector machine model trained on OCT-derived structural metrics and chronological age. Using multivariable linear regression, higher BCS was associated with thicker neuroretinal layers, photoreceptor layers, and overall macular thickness. Exploratory indirect-effect analyses identified candidate metabolic patterns primarily involving lipid, unsaturated fatty acid, and branched-chain amino acid pathways. Furthermore, each 5-unit increase in BCS was associated with a reduced retinal age gap. Our study identified associations between higher BCS and thicker neuroretinal and photoreceptor layers, as well as a reduced OCT age gap. These findings link a higher BCS to more favorable retinal structural phenotypes and identify candidate metabolic patterns for further investigation.","PeriodicalId":12730,"journal":{"name":"GeroScience","volume":" ","pages":""},"PeriodicalIF":6.0,"publicationDate":"2026-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149136352","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A conserved post-maturity imbalance between housekeeping and integrative genome activity in aging. 衰老过程中内务管理和整合基因组活动之间的保守的成熟后不平衡。

IF 6 2区医学

GeroScience Pub Date : 2026-10-09 DOI: 10.1007/s11357-026-02575-3

Lev Salnikov, Saveli Goldberg, Eugene Pinsky

{"title":"A conserved post-maturity imbalance between housekeeping and integrative genome activity in aging.","authors":"Lev Salnikov, Saveli Goldberg, Eugene Pinsky","doi":"10.1007/s11357-026-02575-3","DOIUrl":"https://doi.org/10.1007/s11357-026-02575-3","url":null,"abstract":"Aging biology still lacks a fully mechanistic explanation for why functional decline accelerates after sexual maturity in the absence of a single initiating pathology. Here, we integrate cross-species epigenetic, transcriptomic, and proteomic datasets to test whether aging is associated with a post-maturity imbalance between two genome partitions: housekeeping genes (HG), which encode the cellular maintenance infrastructure, and integrative genes (IntG), which support specialized tissue functions. We emphasize HG because this compartment defines the basal capacity for repair, proteostasis, biosynthesis, and cell-autonomous survival; changes in HG output may therefore help distinguish candidate upstream regulatory changes from downstream damage signatures. Across datasets, we observe a consistent divergence after sexual maturity: the HG compartment loses transcriptional share in low-renewal tissues, whereas IntG promoter methylation becomes progressively more dispersed, with methylation-mRNA Spearman correlations of rho = -0.15 to -0.28 (five tissues, p < 0.05 FDR) and modest mRNA-protein concordance (rho = 0.204, p < 0.001, n = 6,449), indicating partial post-transcriptional decoupling. These associations are compatible with the continued action of an ontogenetic regulatory program that shifts genome activity toward specialized function at the expense of maintenance. This interpretation is consistent with hyperfunction/developmental theories, while reframing the hyperfunctional state as a possible downstream consequence of asymmetric developmental regulation. Although causality remains to be tested experimentally, the convergence of multi-omics evidence supports a testable model in which restoring HG/IntG regulatory balance may represent a future experimental direction for modulating age-related decline, rather than a translational implication supported by the current data.","PeriodicalId":12730,"journal":{"name":"GeroScience","volume":" ","pages":""},"PeriodicalIF":6.0,"publicationDate":"2026-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149136424","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Mitochondrial dysfunction and inflammaging: a mechanistic bridge between bioenergetic failure and senescence. 线粒体功能障碍和炎症：生物能量衰竭和衰老之间的机械桥梁。

IF 6 2区医学

GeroScience Pub Date : 2026-10-09 DOI: 10.1007/s11357-026-02588-y

Salvatore Nesci, Cristina Algieri

{"title":"Mitochondrial dysfunction and inflammaging: a mechanistic bridge between bioenergetic failure and senescence.","authors":"Salvatore Nesci, Cristina Algieri","doi":"10.1007/s11357-026-02588-y","DOIUrl":"https://doi.org/10.1007/s11357-026-02588-y","url":null,"abstract":"Ageing is characterized by a progressive decline in mitochondrial integrity that extends beyond impaired energy production to include redox imbalance, defective quality control, altered organelle dynamics, and persistent inflammatory signalling. This review examines mitochondrial dysfunction as a mechanistic bridge linking bioenergetic failure to cellular senescence and inflammaging, two central features of biological ageing. We discuss how impaired oxidative phosphorylation, loss of mitochondrial membrane potential, increased electron leak, and excessive reactive oxygen species progressively damage mitochondrial DNA, proteins, and lipids, thereby amplifying organelle dysfunction and compromising cellular homeostasis. Particular emphasis is placed on the threshold effect of mitochondrial DNA mutations, whose age-dependent clonal expansion can drive respiratory chain deficiency in vulnerable tissues. We further analyze mitochondria as signalling platforms that integrate regulated cell death, including apoptosis, necroptosis, pyroptosis, and ferroptosis, and as sources of mitochondrial damage-associated molecular patterns promoting sterile inflammation. Finally, we highlight mitochondrial dysfunction-associated senescence as a central process through which persistent mitochondrial stress reshapes the senescence-associated secretory phenotype and reinforces inflammaging. Overall, the evidence supports a model in which dysfunctional mitochondria act as both initiators and amplifiers of senescence and inflammation, contributing to tissue degeneration and age-related functional decline. Understanding these interconnected mechanisms may help identify therapeutic strategies targeting mitochondrial bioenergetics, inflammatory signalling, and senescent cell burden in ageing.","PeriodicalId":12730,"journal":{"name":"GeroScience","volume":" ","pages":""},"PeriodicalIF":6.0,"publicationDate":"2026-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149147966","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Association between community toilet deprivation and depression among older adults in India: a multilevel analysis of the Longitudinal Aging Study in India from 2017-2018 印度老年人社区厕所匮乏与抑郁症之间的关系：2017-2018年印度纵向老龄化研究的多层次分析

IF 5.6 2区医学

GeroScience Pub Date : 2026-10-07 DOI: 10.1007/s11357-026-02537-9

Anoop Jain,Rockli Kim,S. V. Subramanian

引用次数: 0

Dietary preference, biological aging, and incident dementia: a prospective cohort study 饮食偏好、生物衰老和痴呆：一项前瞻性队列研究

IF 5.6 2区医学

GeroScience Pub Date : 2026-10-07 DOI: 10.1007/s11357-026-02567-3

Mengtong Sun,Feng Huang,Na Sun,Huimin Ding,Fuyan Shi,Suzhen Wang,Jiazhen Yao,Qida He

引用次数: 0

IF 6 2区医学

GeroScience Pub Date : 2026-10-07 DOI: 10.1007/s11357-026-02571-7

Marta Paź, Maciej Kamiński, Anna Nowicka

{"title":"Age-related differences in neural activity and functional connectivity during self- and other-referential processing: An EEG study.","authors":"Marta Paź, Maciej Kamiński, Anna Nowicka","doi":"10.1007/s11357-026-02571-7","DOIUrl":"https://doi.org/10.1007/s11357-026-02571-7","url":null,"abstract":"Research on brain aging has largely focused on neurological disorders such as Alzheimer's disease, mild cognitive impairment, and other forms of cognitive decline. However, relatively few studies have examined how age affects self-knowledge in healthy older adults. Thus, the present study aimed to investigate the impact of age on the neural correlates of self-referential and other-referential processing, as well as patterns of task-related connectivity. To this end, trait adjectives were presented to younger and older adults, who evaluated their suitability for describing the self, a close other, and a famous person while EEG data were recorded. EEG analyses focused on the early attention-related positivity (P1) and the late positive potential (LPP), reflecting enhanced processing of salient stimuli, as well as task-related functional connectivity assessed using the full-frequency directed transfer function. Compared to younger adults, older participants exhibited lower P1 amplitudes, indicating reduced attentional engagement. In the older group, LPP amplitudes associated with self-related personality traits were higher than in the younger group. This enhanced LPP may suggest stronger emotional responses to self-related traits and/or increased cognitive effort during self-evaluation. Overall, directed connectivity analyses revealed reduced information flow in older adults along both bottom-up and top-down pathways, including feed-forward signaling from perceptual regions to higher-order evaluative systems, as well as feedback signaling from internally oriented networks to sensory regions. Age-related differences were also evident in local connectivity patterns, with younger participants exhibiting stronger within-region connectivity than older participants in perceptual processing regions and regions supporting internally oriented cognitive processes.","PeriodicalId":12730,"journal":{"name":"GeroScience","volume":" ","pages":""},"PeriodicalIF":6.0,"publicationDate":"2026-10-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149127205","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Resolvin E1 promotes the resolution of inflammation and enhances myogenic responses during aged skeletal muscle regeneration. Resolvin E1促进炎症的消退，增强老年骨骼肌再生过程中的肌源性反应。

IF 6 2区医学

GeroScience Pub Date : 2026-10-07 DOI: 10.1007/s11357-026-02566-4

Ryan Arsenault, Anthony Ziadeh, Amal Assebbane, Haimen Yezihalem, Alexander Green, Junio Dort

{"title":"Resolvin E1 promotes the resolution of inflammation and enhances myogenic responses during aged skeletal muscle regeneration.","authors":"Ryan Arsenault, Anthony Ziadeh, Amal Assebbane, Haimen Yezihalem, Alexander Green, Junio Dort","doi":"10.1007/s11357-026-02566-4","DOIUrl":"https://doi.org/10.1007/s11357-026-02566-4","url":null,"abstract":"Efficient muscle regeneration relies on the coordinated crosstalk between muscle stem cells (MuSCs) and their surrounding niche. Specialized pro-resolving mediators (SPMs), like resolvins, serve as critical autocrine and paracrine signals within this microenvironment, with macrophages acting as one of the primary sources of SPMs required to resolve inflammation and boost myogenesis. However, while dysregulation of endogenous SPM synthesis in aged skeletal muscle is known to drive chronic inflammation, the specific role of these lipid mediators during aged muscle regeneration remains poorly characterized. Here, we examine whether Resolvin E1 (RvE1) can accelerate the resolution of inflammation and improve the regenerative capacity of aged skeletal muscle. In vitro, RvE1 reduces pro-inflammatory gene expression and drives macrophages toward an anti-inflammatory phenotype. In aged mice, post-injury RvE1 treatment accelerates neutrophil clearance, expands the myogenic cell pool, and enhances myoblast differentiation, resulting in a trend toward improved muscle contractile function. Overall, our findings suggest that RvE1 is a therapeutic candidate that enhances aged muscle regeneration by concurrently resolving inflammation and driving myogenesis.","PeriodicalId":12730,"journal":{"name":"GeroScience","volume":" ","pages":""},"PeriodicalIF":6.0,"publicationDate":"2026-10-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149127282","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Against the “extend healthspan but not lifespan” cliché 反对“延长健康寿命，但不能延长寿命”的陈词滥调

IF 5.6 2区医学

GeroScience Pub Date : 2026-10-07 DOI: 10.1007/s11357-026-02577-1

David Gems,Ekaterina R. Iijima,João Pedro de Magalhães

引用次数: 0

Association of systemic aging and frailty with retinal alterations: insights from an integrated exposome and metabolome framework 系统性衰老和衰弱与视网膜改变的关联：来自综合暴露体和代谢组框架的见解

IF 5.6 2区医学

GeroScience Pub Date : 2026-10-06 DOI: 10.1007/s11357-026-02572-6

Tianhao Chen,Di Wang,Yong Ma,Yuhao Ye,Xuejun Wang,Yuan Lei,Xingtao Zhou,Jing Zhao

引用次数: 0

Sensory gamma entrainment in older adults with or without cognitive impairment: a systematic review and exploratory meta-analysis 有或无认知障碍的老年人的感觉伽马夹带：一项系统回顾和探索性荟萃分析