GeroScience最新文献

{"title":"Ndufs4^-/- mice: a testing ground for longevity interventions.","authors":"Jackson Nuss, Matt Kaeberlein, Alessandro Bitto, Anthony S Grillo","doi":"10.1007/s11357-025-01704-8","DOIUrl":"10.1007/s11357-025-01704-8","url":null,"abstract":"<p><p>Mice missing the complex I subunit Ndufs4 of the electron transport chain are widely used as a leading animal model of Leigh syndrome, a pediatric neurodegenerative disorder that leads to premature death. More broadly, this animal model has enabled a better understanding of the pathophysiology of mitochondrial disease and mitochondrial dysfunction in sporadic disorders. Intriguingly, longevity interventions are very effective at treating symptoms of disease in this model. Herein, we introduce the model and its notable features that may help provide insights in longevity research. We performed a retrospective analysis of historical data from our laboratories over the past 10 years regarding the use of this animal model in aging studies, the manifestation and progression of mitochondrial disease, and factors that influence their premature death. We observed a correlation between weight and lifespan in female animals and a sex-independent correlation between the onset of clasping, a typical neurodegenerative symptom, and overall survival. We observed a sexual dimorphism in lifespan with female mice being more resilient despite a similar age of onset of disease symptoms. Lastly, we report increased lifespan and delayed onset of disease symptoms following treatment with 17-alpha-estradiol, a non-feminizing estrogen which can extend lifespan in genetically heterogeneous mice. This analysis serves as a useful guide for researchers utilizing this animal in the discovery of effective interventions for longevity and to prevent the onset of disease. It suggests there may be unprecedented underlying sex-specific differences in patients with Leigh syndrome and further strengthens the connection between normative aging and mitochondrial dysfunction.</p>","PeriodicalId":12730,"journal":{"name":"GeroScience","volume":" ","pages":""},"PeriodicalIF":5.3,"publicationDate":"2025-06-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144225217","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Morphological features of the domestic house cricket (Acheta domesticus) for translational aging studies.","authors":"Gerald Yu Liao, Sherwin Dai, Elizabeth Bae, Swastik Singh, Jenna Klug, Christina Pettan-Brewer, Warren Ladiges","doi":"10.1007/s11357-025-01711-9","DOIUrl":"https://doi.org/10.1007/s11357-025-01711-9","url":null,"abstract":"<p><p>Aging alters morphology and locomotor function in diverse organisms, yet standardized model systems for studying these changes remain limited to a relatively few species. Here, we present a comprehensive analysis of age- and sex-dependent morphological variations in house crickets (Acheta domesticus), integrating refined husbandry protocols to enhance reproducibility and translational relevance. To ensure data consistency, we implemented a standardized husbandry framework incorporating self-determined photoperiods, co-housing both sexes, and controlled diet and hydration strategies. We observed progressive increases in body weight, length, and appendage dimensions with age, with pronounced sexual dimorphism emerging post-maturity. Structural adaptations, including increased femoral volume and cross-sectional area, suggest compensatory mechanisms for age-related declines in muscle efficiency, while reduced hind leg-to-body length ratios indicate potential biomechanical constraints on locomotion. Furthermore, antennal growth patterns highlight prolonged sensory investment, potentially offsetting declining mobility in aging individuals. Our results underscore the necessity of harmonizing environmental conditions in gerontological research, as variations in lighting, substrate availability, and microbiome exposure may significantly impact physiological resilience and behavioral fidelity. Future work should explore the influence of microbiome diversity on lifespan and stress resilience while refining methodologies for cricket rearing from egg to adulthood. By bridging invertebrate and vertebrate aging research, this study positions house crickets as a scalable, high-throughput animal model for investigating age-related functional decline, behavioral plasticity, and lifespan-extending interventions. Integrating behavioral assays, biomechanical analyses, and molecular markers of aging will further elucidate the interplay between morphology, function, health, and longevity, advancing the utility of crickets in comparative geroscience.</p>","PeriodicalId":12730,"journal":{"name":"GeroScience","volume":" ","pages":""},"PeriodicalIF":5.3,"publicationDate":"2025-06-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144215647","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Platelet hyperreactivity and frailty in a mouse model of Alzheimer's disease are prevented by anti-oxidant treatment.","authors":"Mauro Vismara, Silvia Maria Grazia Trivigno, Marta Zarà, Stefania Momi, Paolo Gresele, Marina Camera, Ilaria Canobbio, Gianni Francesco Guidetti, Mauro Torti","doi":"10.1007/s11357-025-01710-w","DOIUrl":"https://doi.org/10.1007/s11357-025-01710-w","url":null,"abstract":"<p><p>Frailty is an age-related syndrome commonly associated with different comorbidities, and its occurrence is particularly frequent in patients with Alzheimer's disease (AD). A persisting low-grade inflammation has been suggested to favor the onset of both AD and frailty. Besides their role in hemostasis and thrombosis, blood platelets are true inflammatory cells, and their direct contribution to the onset and progression of AD has been documented. In this work, we investigated whether platelet hyperreactivity and pro-oxidative functions are implicated in the development of frailty in a mouse model of AD, the APP23 mice. Assessment of 31 specific clinical signs of deterioration in mice at 3, 9, and 18 months of age demonstrated that the development of frailty was significantly more pronounced in the APP23 mice compared to wild-type littermates. In 18-month-old APP23 mice, a significant platelet hyperreactivity was detected as shown by a significantly stronger platelet aggregation in response to submaximal stimulation of both collagen and thrombin receptors. Moreover, the pro-inflammatory function of platelets, evaluated as circulating and agonist-induced platelet-neutrophil aggregate formation, was significantly increased in aged APP23 mice compared to wild-type littermates. Platelet hyperreactivity was partially prevented by prolonged treatment with the anti-oxidant agent Tempol, which reduced both agonist-induced aggregation and platelet-neutrophil aggregate formation. Importantly, prolonged treatment of APP23 mice with Tempol significantly reduced also the frailty index score in 18-month-old animals. These results outline the possible beneficial effect of an anti-oxidant treatment in hampering platelet hyperreactivity and preventing the onset of frailty associated to AD.</p>","PeriodicalId":12730,"journal":{"name":"GeroScience","volume":" ","pages":""},"PeriodicalIF":5.3,"publicationDate":"2025-06-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144208415","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sustained and reversible effects of a dietary phosphate intake on bone and mineral metabolism during aging.","authors":"Jamie L Arnst, Uma D Alappan, Manjula Viggeswarapu, George R Beck","doi":"10.1007/s11357-025-01714-6","DOIUrl":"https://doi.org/10.1007/s11357-025-01714-6","url":null,"abstract":"<p><p>The loss of bone volume during aging is common in both men and women and can have substantial negative health impacts. Weakened bones can lead to fractures which in turn can result in hospitalization, decreased quality of life, and early death. The post-diagnosis treatment of osteoporosis has received the bulk of attention with less research focused on prevention and modifiable risk factors such as nutrition. Calcium and vitamin D supplementation has provided limited skeletal benefit in healthy individuals and there is no currently sufficient information on other components of the diet for informed dietary choices related to bone health. Inorganic phosphate (Pi) is a dietary element that is consumed in excess in most Western diets and has been suggested to strongly influence bone metabolism. However, how duration of dietary Pi choices, stage of life, and gender influence the impact on long-term bone health is lacking. To address these issues, young (10 week) and old (82 week) male mice were fed low, normal, or high Pi content diets with calcium kept constant at 0.6% for 10 weeks and bone indices and Pi-responsive serum factors were measured. To determine if changes in bone quality in response to changes in dietary Pi were chronic or could be reversed, additional groups of mice were fed low or high Pi diets for 10 weeks and switched back to normal Pi for the final 10 weeks. A low-Pi additive diet produced a significant increase in trabecular and cortical bone volume in both young and old male mice. The high Pi diet generated trabecular bone loss in young mice which was not reversible by switching back to a normal Pi diet. The high Pi diet also induced accelerated loss of cortical bone and kidney calcification in old mice. Taken together, the results suggest that dietary choices made early in life could have long-term consequences on bone health and identify a novel non-pharmacologic, modifiable nutritional choice, in a low-Pi additive diet that could be used to build bone mass and/or prevent bone loss in the elderly.</p>","PeriodicalId":12730,"journal":{"name":"GeroScience","volume":" ","pages":""},"PeriodicalIF":5.3,"publicationDate":"2025-06-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144198926","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of aging and exercise on hTERT expression in thymus tissue of hTERT transgenic bacterial artificial chromosome mice.","authors":"Jeongjin J Kim, Alexander Ahn, Jeffrey Y Ying, Jesse Pollens-Voigt, Andrew T Ludlow","doi":"10.1007/s11357-024-01319-5","DOIUrl":"10.1007/s11357-024-01319-5","url":null,"abstract":"<p><p>Telomere shortening occurs with aging in immune cells and may be related to immunosenescence. Exercise can upregulate telomerase activity and attenuate telomere shortening in immune cells, but it is unknown if exercise impacts other immune tissues such as the thymus. This study aimed to examine human telomerase reverse transcriptase (hTERT) alternative splicing (AS) in response to aging and exercise in thymus tissue. Transgenic mice with a human TERT bacterial artificial chromosome integrated into its genome (hTERT-BAC) were utilized in two different exercise models. Mice of different ages were assigned to an exercise cage (running wheel) or not for 3 weeks prior to thymus tissue excision. Middle-aged mice (16 months) were exposed or not to treadmill running (30 min at 60% maximum speed) prior to thymus collection. hTERT transcript variants were measured by RT-PCR. hTERT transcripts decreased with aging (r =  - 0.7511, p < 0.0001) and 3 weeks of wheel running did not counteract this reduction. The ratio of exons 7/8 containing hTERT to total hTERT transcripts increased with aging (r = 0.3669, p = 0.0423) but 3 weeks of voluntary wheel running attenuated this aging-driven effect (r = 0.2013, p = 0.4719). Aging increased the expression of senescence marker p16 with no impact of wheel running. Thymus regeneration transcription factor, Foxn1, went down with age with no impact of wheel running exercise. Acute treadmill exercise did not induce any significant changes in thymus hTERT expression or AS variant ratio (p > 0.05). In summary, thymic hTERT expression is reduced with aging. Exercise counteracted a shift in hTERT AS ratio with age. Our data demonstrate that aging impacts telomerase expression and that exercise impacts dysregulated splicing that occurs with aging.</p>","PeriodicalId":12730,"journal":{"name":"GeroScience","volume":" ","pages":"3325-3341"},"PeriodicalIF":5.3,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12181544/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142106685","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Active longevity and aging: dissecting the impacts of physical and sedentary behaviors on longevity and age acceleration.","authors":"Ting Yu Lu, Jiao Wang, Chao Qiang Jiang, Ya Li Jin, Kar Keung Cheng, Tai Hing Lam, Wei Sen Zhang, Lin Xu","doi":"10.1007/s11357-024-01329-3","DOIUrl":"10.1007/s11357-024-01329-3","url":null,"abstract":"<p><strong>Background: </strong>To examine the associations of physical activity (PA) and sedentary behavior (SB) with longevity and age acceleration (AA) using observational and Mendelian randomization (MR) studies, and quantify the mediating effects of lipids.</p><p><strong>Methods: </strong>In Guangzhou Biobank Cohort Study (GBCS), PA and SB were assessed by the Chinese Version of the International Physical Activity Questionnaire. Longevity was defined as participants whose age at follow-up or at death was at or above the 90th age percentile. AA was defined as the residual resulting from a linear model that regressed phenotypic age against chronological age. Linear regression and Poisson regression with robust error variance were used to assess the associations of total and specific PA in different intensities, and SB with AA and longevity, yielding βs or relative risks (RRs) and 95% confidence intervals (CIs). Two-sample MR was conducted to examine the causal effects. Mediation analysis was used to assess the mediating effects of lipids.</p><p><strong>Results: </strong>Of 20,924 participants aged 50 + years in GBCS, during an average follow-up of 15.0 years, compared with low PA, moderate and high PA were associated with higher likelihood of longevity (RR (95% CI): 1.56 (1.16, 2.11), 1.66 (1.24, 2.21), respectively), and also cross-sectionally associated with lower AA (β (95% CI): -1.43 (-2.41, -0.45), -2.09 (-3.06, -1.11) years, respectively). Higher levels of moderate PA (MPA) were associated with higher likelihood of longevity and lower AA, whereas vigorous PA (VPA) showed opposite effects. The association of PA with longevity observed in GBCS was mediated by low-density lipoprotein cholesterol (LDL-C) by 8.23% (95% CI: 3.58-39.61%), while the association with AA was mediated through LDL-C, triglycerides and total cholesterol by 5.13% (3.94-7.30%), 7.81% (5.98-11.17%), and 3.37% (2.59-4.80%), respectively. Additionally, in two-sample MR, SB was positively associated with AA (β (95% CI): 1.02 (0.67, 1.36) years).</p><p><strong>Conclusions: </strong>PA showed protective effects on longevity and AA, with the effects being partly mediated through lipids. Conversely, SB had a detrimental impact on AA. MPA was associated with higher likelihood of longevity and reduced AA, whereas VPA showed adverse effects. Our findings reinforce the recommendation of \"sit less and move more\" to promote healthy longevity, and highlight the potential risks associated with VPA in the elderly.</p>","PeriodicalId":12730,"journal":{"name":"GeroScience","volume":" ","pages":"3525-3538"},"PeriodicalIF":5.3,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12181555/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142125489","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Age-related alterations in vortex veins on indocyanine green angiography.","authors":"Chen-Xi Cai, Shan-Shan Yu, Xiao-Mei Xiong, Bing-Qian Liu, Zhen-Qiang Lin, Qiang Wang, Jin-Li Cui, Ze-Hao Liu, Tao Li, Lin Lu, Ying Lin","doi":"10.1007/s11357-024-01298-7","DOIUrl":"10.1007/s11357-024-01298-7","url":null,"abstract":"<p><p>To determine age-related alterations in vortex veins in healthy subjects. A total of 228 healthy subjects (aged 4 to 86 years) were recruited and divided into four groups (G1, <21 years; G2, 21-40 years; G3, 41-60 years; and G4, 61-86 years). The clinical characteristics of the participants were recorded, and parameters including the number of vortex vein roots (NVVR), the central vortex vein diameter (CVVD), the mean root area of the vortex vein (MRAVV), and the weighted mean of the thickest branch diameter (WMTBD) were obtained by marking the vortex veins on indocyanine green angiography (ICGA). The NVVR in the age group over 60 years old was significantly lower than that in other age groups (P < 0.05). The CVVD, MRAVV, and WMTBD of all age groups increased with increasing age (P < 0.05). The NVVR was unevenly distributed among the quadrants (P < 0.001). The proportions of type four vortex veins (complete systems including ampulla) and anastomotic branches of the vortex veins were significantly increased in elderly participants over 50 years of age (P < 0.05). Subfoveal choroidal thickness was significantly correlated with age, NVVR, CVVD and MRAVV (P < 0.05). This is the first study to reveal age-related alterations in vortex veins on ICGA in a healthy population. Aging may lead to partial vortex occlusion and residual vortex dilation. As age increases, anastomotic branches increasingly appear between the originally independent vortex veins. Translational relevance: Aging may lead to partial vortex occlusion and residual vortex dilation.</p>","PeriodicalId":12730,"journal":{"name":"GeroScience","volume":" ","pages":"3291-3298"},"PeriodicalIF":5.3,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12181557/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141982094","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Maternal α-casein deficiency extends the lifespan of offspring and programmes their body composition.","authors":"Andreas F Kolb, Claus Mayer, Alina Zitskaja, Linda Petrie, Khulod Hasaballah, Claire Warren, Ailsa Carlisle, Simon Lillico, Bruce Whitelaw","doi":"10.1007/s11357-024-01273-2","DOIUrl":"10.1007/s11357-024-01273-2","url":null,"abstract":"<p><p>Early nutrition has significant effects on physiological outcomes during adult life. We have analysed the effect of maternal α-casein (CSN1S1) deficiency on the physiological fate of dams and their offspring. α-casein deficiency reduces maternal milk protein concentration by more than 50% and attenuates the growth of pups to 27% (p < 0.001) of controls at the point of weaning. This is associated with a permanent reduction in adult body weight (- 31% at 25 weeks). Offspring nursed by α-casein deficient dams showed a significantly increased lifespan (+ 20%, χ²: 10.6; p = 0.001). Liver transcriptome analysis of offspring nursed by α-casein deficient dams at weaning revealed gene expression patterns similar to those found in dwarf mice (reduced expression of somatotropic axis signalling genes, increased expression of xenobiotic metabolism genes). In adult mice, the expression of somatotropic axis genes returned to control levels. This demonstrates that, in contrast to dwarf mice, attenuation of the GH-IGF signalling axis in offspring nursed by α-casein deficient dams is transient, while the changes in body size and lifespan are permanent. Offspring nursed by α-casein deficient dams showed permanent changes in body composition. Absolute and relative adipose tissue weights (p < 0.05), the percentage of body fat (p < 0.001) as well as adipocyte size in epididymal white adipose tissue are all reduced. Serum leptin levels were 25% of those found in control mice (p < 0.001). Liver lipid content and lipid composition were significantly altered in response to postnatal nutrition. This demonstrates the nutrition in early life programmes adult lipid metabolism, body composition and lifespan.</p>","PeriodicalId":12730,"journal":{"name":"GeroScience","volume":" ","pages":"3217-3239"},"PeriodicalIF":5.3,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12181513/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141590062","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparative phenotyping of C57BL/6J substrains reveals distinctive patterns of cardiac aging.","authors":"Sophia Walter, Patricia Baumgarten, Niklas Hegemann, Steffen P Häseli, Stefanie Deubel, Julia Jelleschitz, Annika Höhn, Nikolaus Berndt, Wolfgang M Kuebler, Jana Grune, Christiane Ott","doi":"10.1007/s11357-025-01543-7","DOIUrl":"10.1007/s11357-025-01543-7","url":null,"abstract":"<p><p>Research in aging often refers to animal models, particularly C57BL/6J (B6J) mice, considered gold standard. However, B6J mice are distributed by different suppliers, which results in divers substrains exhibiting notable phenotypic differences. To ensure a suitable phenotype of cardiac aging, we performed heart analyses of young (5 months) and old B6J mice (24 months) from two substrains: B6JRj (Janvier) and B6JCrl mice (Charles River). In hearts of both substrains, myocardial fibrosis increased with age; however, only in old B6JRj mice cardiac hypertrophy associated with a decreased ejection fraction was observed. Gene set enrichment analysis in heart tissue using proteomic data revealed different age-associated pathway changes between the substrains, especially in oxidative phosphorylation. Functional assessment of isolated cardiomyocytes verified cardiac impairment during aging in B6JRj mice. Overall, results demonstrate that cardiac aging manifests as a moderate systolic dysfunction in B6JRj mice, while B6JCrl mice display no functional changes with age.</p>","PeriodicalId":12730,"journal":{"name":"GeroScience","volume":" ","pages":"4795-4812"},"PeriodicalIF":5.3,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12181499/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143064368","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The RESIST Senior Individuals Cohort: Design, participant characteristics and aims.","authors":"Lennart Matthias Roesner, Manoj Kumar Gupta, Verena Kopfnagel, Nienke van Unen, Yvonne Kemmling, Jana-Kristin Heise, Stephanie Castell, Xun Jiang, Lennart Riemann, Stephan Traidl, Berit Lange, Kurt-Wolfram Sühs, Thomas Illig, Till Strowig, Yang Li, Reinhold Förster, Jochen Huehn, Thomas Friedrich Schulz, Thomas Werfel","doi":"10.1007/s11357-024-01299-6","DOIUrl":"10.1007/s11357-024-01299-6","url":null,"abstract":"<p><p>The number of older adults worldwide is growing exponentially. However, while living longer, older individuals are more susceptible to both non-infectious and infectious diseases, at least in part due to alterations of the immune system. Here, we report on a prospective cohort study investigating the influence of age on immune responses and susceptibility to infection. The RESIST Senior Individuals (SI) cohort was established as a general population cohort with a focus on the elderly, enrolling an age- and sex-stratified sample of 650 individuals (n = 100 20-39y, n = 550 61-94y, 2019-2023, Hannover, Germany). It includes clinical, demographic, and lifestyle data and also extensive biomaterial sampling. Initial insights indicate that the SI cohort exhibits characteristics of the aging immune system and the associated susceptibility to infection, thereby providing a suitable platform for the decoding of age-related alterations of the immune system and unraveling the molecular mechanisms underlying the impaired immune responsiveness in aging populations by exploring comprehensive, unbiased multi-omics datasets.</p>","PeriodicalId":12730,"journal":{"name":"GeroScience","volume":" ","pages":"3299-3310"},"PeriodicalIF":5.3,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12181556/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141975530","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}