The RESIST Senior Individuals Cohort: Design, participant characteristics and aims.

IF 5.4 2区医学 Q1 GERIATRICS & GERONTOLOGY

GeroScience Pub Date : 2025-06-01 Epub Date: 2024-08-14 DOI:10.1007/s11357-024-01299-6

Lennart Matthias Roesner, Manoj Kumar Gupta, Verena Kopfnagel, Nienke van Unen, Yvonne Kemmling, Jana-Kristin Heise, Stephanie Castell, Xun Jiang, Lennart Riemann, Stephan Traidl, Berit Lange, Kurt-Wolfram Sühs, Thomas Illig, Till Strowig, Yang Li, Reinhold Förster, Jochen Huehn, Thomas Friedrich Schulz, Thomas Werfel

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Abstract

The number of older adults worldwide is growing exponentially. However, while living longer, older individuals are more susceptible to both non-infectious and infectious diseases, at least in part due to alterations of the immune system. Here, we report on a prospective cohort study investigating the influence of age on immune responses and susceptibility to infection. The RESIST Senior Individuals (SI) cohort was established as a general population cohort with a focus on the elderly, enrolling an age- and sex-stratified sample of 650 individuals (n = 100 20-39y, n = 550 61-94y, 2019-2023, Hannover, Germany). It includes clinical, demographic, and lifestyle data and also extensive biomaterial sampling. Initial insights indicate that the SI cohort exhibits characteristics of the aging immune system and the associated susceptibility to infection, thereby providing a suitable platform for the decoding of age-related alterations of the immune system and unraveling the molecular mechanisms underlying the impaired immune responsiveness in aging populations by exploring comprehensive, unbiased multi-omics datasets.

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RESIST 老年群体：设计、参与者特征和目的。

全世界老年人的数量呈指数级增长。然而，在寿命延长的同时，老年人更容易感染非传染性疾病和传染性疾病，至少部分原因是免疫系统发生了变化。在此，我们报告了一项前瞻性队列研究，调查年龄对免疫反应和感染易感性的影响。RESIST Senior Individuals（SI）队列是作为一个以老年人为重点的普通人群队列而建立的，共招募了650名年龄和性别分层样本（n = 100 20-39岁，n = 550 61-94岁，2019-2023年，德国汉诺威）。其中包括临床、人口统计学和生活方式数据，以及大量生物材料取样。初步研究结果表明，SI 队列显示了老龄化免疫系统的特征和相关的感染易感性，从而为解码与年龄相关的免疫系统改变提供了一个合适的平台，并通过探索全面、无偏见的多组学数据集，揭示了老龄化人群免疫反应能力受损的分子机制。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

GeroScience Medicine-Complementary and Alternative Medicine

CiteScore

10.50

自引率

5.40%

发文量

182

期刊介绍： GeroScience is a bi-monthly, international, peer-reviewed journal that publishes articles related to research in the biology of aging and research on biomedical applications that impact aging. The scope of articles to be considered include evolutionary biology, biophysics, genetics, genomics, proteomics, molecular biology, cell biology, biochemistry, endocrinology, immunology, physiology, pharmacology, neuroscience, and psychology.