GeroScience最新文献

{"title":"The aging choroid plexus and its relationship with gut dysbiosis and Klotho decline: possible intervention strategies.","authors":"Giovanni Lai,Lisa Bevilacqua,Maria Elisa Giuliani,Giorgia Bigossi,Serena Marcozzi,Tiziana Casoli,Pasqua Abbrescia,Antonio Frigeri,Marco Malavolta,Marta Balietti","doi":"10.1007/s11357-025-01797-1","DOIUrl":"https://doi.org/10.1007/s11357-025-01797-1","url":null,"abstract":"The choroid plexus (ChP) is a complex ventricular structure that forms a semi-permeable barrier between the blood and cerebrospinal fluid (CSF). It is responsible for CSF secretion and clearance, contains macrophages, and is one of the few sites within the central nervous system (CNS) where T cells are present. Additionally, the ChP plays a role in detecting peripheral inflammation, which leads to the modulation of its epithelial cell function. Despite its critical importance in maintaining brain homeostasis, the ChP is often overlooked, particularly concerning the changes it undergoes with aging, such as reduced barrier function, impaired CSF production, and altered immunosurveillance. These age-related alterations may contribute to several harmful effects, including neuroinflammation and oxidative damage, potentially predisposing individuals to neurodegenerative conditions. Although knowledge is still limited, gut dysbiosis and decreased Klotho levels-of which the ChP is one of the main sources-appear to be significant contributors to ChP impairments. This narrative review will examine the impact of age-related gut dysbiosis on the CNS, focusing on the ChP, and explore the effects of reduced Klotho levels in this brain structure. We will also propose the hypothesis that combining the administration of probiotics capable of restoring gut microbiota eubiosis with gene therapy to upregulate Klotho in the ChP could help preserve the structural and functional integrity of the aging brain. Finally, we will provide a technical overview to ensure that vectors encoding Klotho cDNA achieve maximum specificity for the ChP, thereby avoiding off-target effects.","PeriodicalId":12730,"journal":{"name":"GeroScience","volume":"29 1","pages":""},"PeriodicalIF":5.6,"publicationDate":"2025-07-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144678107","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Vitamin D deficiency as a risk factor for cognitive decline in individuals aged 50 or older.","authors":"Natália Cochar-Soares,Thaís Barros Pereira da Silva,Mariane Marques Luiz,Patricia Silva Tofani,Maicon Luis Bicigo Delinocente,Roberta de Oliveira Máximo,Andrew Steptoe,Cesar de Oliveira,Tiago da Silva Alexandre","doi":"10.1007/s11357-025-01800-9","DOIUrl":"https://doi.org/10.1007/s11357-025-01800-9","url":null,"abstract":"Longitudinal studies provide conflicting evidence regarding the impact of vitamin D deficiency on cognitive performance in older individuals. The present study aimed to investigate whether vitamin D deficiency is a risk factor for poorer trajectories in global cognition and specific cognitive domains over a six-year follow-up period. This cohort study analysed data from 2625 participants aged 50 years or older from the English Longitudinal Study of Ageing. Vitamin D [25-hydroxyvitamin D, 25(OH)D] was classified as sufficient (> 75 nmol/L), insufficient (> 30 and ≤ 75 nmol/L), or deficient (≤ 30 nmol/L). Cognitive performance was assessed using the verbal fluency test, word list test, temporal orientation test, and global cognition, standardised in z-scores by age group and educational level. Generalised linear mixed models, adjusted for sociodemographic, behavioural, and clinical variables, estimated rates of decline in global cognition and cognitive domains based on vitamin D status. Participants with vitamin D deficiency showed greater declines in the z-score of global cognition (- 0.037 standard deviations (SD) per year; 95% CI: - 0.069 to - 0.005) and executive function (- 0.038 SD per year; 95% CI: - 0.071 to - 0.004) compared to those with sufficient vitamin D levels. No significant differences were observed in the trajectories of memory or temporal orientation in relation to vitamin D status. Vitamin D deficiency is a risk factor for declines in global cognition and executive function in individuals aged 50 or older. The assessment and management of vitamin D levels may be crucial strategies for promoting cognitive health.","PeriodicalId":12730,"journal":{"name":"GeroScience","volume":"26 1","pages":""},"PeriodicalIF":5.6,"publicationDate":"2025-07-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144669518","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Advancing clinical trial readiness in white matter disease and related dementias: key steps for future research progress.","authors":"Pradoldej Sompol,Gregory A Jicha,Jason D Hinman,Adam M Brickman,Steven M Greenberg,Konstantinos Arfanakis,Marion S Buckwalter,Irene Lorenzo Llorente,Jeff D Williamson,Michael S Wolf,Eric E Smith,Aditi Gupta,Margaret E Flanagan,Miguel A Vazquez,Jeffrey M Burns,S Thomas Carmichael,Frank C Barone","doi":"10.1007/s11357-025-01805-4","DOIUrl":"https://doi.org/10.1007/s11357-025-01805-4","url":null,"abstract":"White matter disease, a broad-spectrum term that covers various types of white matter lesions and degeneration, is strongly related to age-related neurodegenerative disorders including Alzheimer's disease (AD), and vascular contributions to cognitive impairment and dementia (VCID) and Alzheimer's related dementias (ADRD). There is no specific treatment for white matter disease. Therefore, basic research and clinical studies are essential for future outcomes. Since its formation in 2020, the Albert Research Institute for White Matter and Cognition (ARIWMC) mission has been to support white matter research by providing a forum for communication where basic and clinical scientists meet to discuss and debate new knowledge and guidelines for studying white matter in dementia. The 4th annual ARIWMC workshop was held on May 31-June 2, 2023, where researchers met to set strategies for clinical trial readiness. Significant discussion by participants advocated research on multiple levels, including molecular, cellular, metabolic, behavioral, and risk factors that contribute to disease etiology and regeneration processes. Moreover, participants also addressed identifying and validating biomarkers and functional studies in animal models and human trials that are key steps for treatment development. Other areas that were discussed included epidemiological studies and pragmatic clinical trials where health care researchers and everyday medical practice support risk factor management or healthy lifestyle, and prevention trials could mitigate the incident of the disease. In summary, this workshop fostered a better understanding of how white matter lesions contribute to cognitive impairment from bench-to-biomarker-to-bedside-to-translational approaches which will facilitate and support the discovery and development of therapies and prevention strategies that facilitate a healthy brain and reduce white matter-related pathologies associated with and contributing to VCID and ADRD.","PeriodicalId":12730,"journal":{"name":"GeroScience","volume":"47 1","pages":""},"PeriodicalIF":5.6,"publicationDate":"2025-07-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144669534","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Unraveling functional decline: the relationship between muscle strength and ultrasound evaluation of biceps brachii thickness.","authors":"Maria Chiara Brunese,Grazia Daniela Femminella,Leonardo Bencivenga,Francesco Tafuri,Corrado Caiazzo,Giuseppe Rengo,Germano Guerra,Klara Komici","doi":"10.1007/s11357-025-01801-8","DOIUrl":"https://doi.org/10.1007/s11357-025-01801-8","url":null,"abstract":"Skeletal muscle characteristics play a crucial role in understanding physical capacity, overall health, and outcomes. Muscle strength and muscle mass are key indicators of muscular function and sarcopenia. While previous research has explored biceps brachii muscle characteristics in isolation, there is a notable gap in comprehensive studies examining the direct correlation between biceps brachii muscle thickness (BMT), as measured by ultrasound, and muscle strength. In community-dwelling elderly individuals following physical capacity evaluations, anthropometric measurements, HGS, bioimpedance analysis, and muscle ultrasound for the measurement of biceps brachii muscle thickness were performed. The study population consisted of 156 participants; ICC for ultrasound measurements resulted in 0.96 and 95% CI 0.95-0.98, indicating excellent reliability. The Kruskal-Wallis analysis revealed that muscle thickness differed between age tertiles in both male (p = 0.0005) and female populations (p = 0.001). Regression analysis adjusted for age, sex, BMI, muscle mass in percentage, and comorbidities revealed a significant and independent positive correlation between muscle strength and muscle thickness: R2 = 0.70, β = 0.9, 95% CI: 0.7-1.2, and p < 0.001 in male population and R2 = 0.17, β = 0.2, 95% CI: 0.1-0.4, and p = 0.005 in female population. Muscle thickness of biceps brachii measured by ultrasound and handgrip strength is characterized by a significant and positive relationship in older adults. In both female and male populations, the reduction of muscle thickness is parallel to increased age. Implementation of noninvasive ultrasound evaluation of muscle thickness could be helpful in the early detection of physical decline associated with the aging process.","PeriodicalId":12730,"journal":{"name":"GeroScience","volume":"95 1","pages":""},"PeriodicalIF":5.6,"publicationDate":"2025-07-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144664238","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Development of a laboratory-based frailty index for risk prediction in elderly trauma patients with hip fractures.","authors":"Malou-Sophie Dietrich,Emmanouil Liodakis,Stephan Sehmisch,Marcel Winkelmann,Manfred Gogol","doi":"10.1007/s11357-025-01789-1","DOIUrl":"https://doi.org/10.1007/s11357-025-01789-1","url":null,"abstract":"This study aimed to develop a laboratory-based frailty index (FI-Lab) to predict 12-month mortality risk in elderly patients following a hip fracture (HF). A retrospective analysis of 235 consecutive patients over 70 years old, who underwent HF surgery, was conducted. The FI-Lab, based on 21 routine blood parameters, was evaluated using Receiver Operating Characteristics, Area Under the Curve (AUC), Kaplan-Meier curves, and Cox proportional Hazard ratios. The FI-Lab showed an AUC of 0.7177 for 6-month and 0.7423 for 1-year survival. High FI-Lab values correlated with higher preoperative ASA scores, longer time-to-surgery times, more perioperative transfusions, and higher postoperative complication rates. The Cox hazard ratio revealed a significant increase in the risk of death for 1 year and 6 months from a score of 0.4 and higher. These findings highlight the FI-Lab's clinical relevance and validity as a predictive tool, emphasizing the need for differentiated perioperative risk stratification.","PeriodicalId":12730,"journal":{"name":"GeroScience","volume":"74 1","pages":""},"PeriodicalIF":5.6,"publicationDate":"2025-07-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144645944","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Circular RNAs as regulators and biomarkers of mammalian ovarian ageing.","authors":"Arkadiusz Grzeczka,Sharif Iqbal,Kejun Ying,Pawel Kordowitzki","doi":"10.1007/s11357-025-01798-0","DOIUrl":"https://doi.org/10.1007/s11357-025-01798-0","url":null,"abstract":"Ageing is a prevalent characteristic of all cells, tissues, and organs; certain ones, such as the ovaries, undergo significant ageing and do so early in the lifespan of mammals. Despite the widely recognized hormonal regulation occurring in the ovaries, numerous mechanisms influencing ovarian ageing remain unclear. Recently, a long-overlooked consequence of splicing, small RNA molecules, characterized by their circular structure, have gained attention. Circular RNAs (circRNAs) have been identified as products of gene transcription and are categorized among other non-coding molecules. The focus of researchers on circRNAs has been prompted by their remarkable capacity to influence the function of proteins, other RNAs, and genes. As further discoveries emerged, it became evident that these molecules were highly specific to particular tissues, with some being unique to significant physiological processes. The identification of their potential has enriched researchers' understanding regarding ovarian development and ageing, as several crucial connections to genes and ageing pathways have been revealed in current studies. This review article elucidates the significance of circRNA concerning the developmental competency and ageing of the ovary and suggests its potential as a biomarker for mammalian ovarian ageing.","PeriodicalId":12730,"journal":{"name":"GeroScience","volume":"679 1","pages":""},"PeriodicalIF":5.6,"publicationDate":"2025-07-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144652859","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"One-year concurrent training improves physical performance and handgrip strength in nursing home residents.","authors":"Duarte Barros,Jonas Johansson,Tom Wilsgaard,José Magalhães,Joana Carvalho,Elisa A Marques","doi":"10.1007/s11357-025-01770-y","DOIUrl":"https://doi.org/10.1007/s11357-025-01770-y","url":null,"abstract":"This parallel two-arm pragmatic controlled trial aimed to examine the effectiveness of a 12-month exercise intervention on physical performance, handgrip strength, independence in basic activities of daily living (BADL), and falls in real-world settings. Ninety-five older residents of nursing homes (mean age 81.9 ± 8.0 years) were allocated to either an exercise (n = 43) or usual care only (n = 52) group. The 12-month exercise training consisted of resistance and aerobic exercises (2 days/week), while the usual care consisted of everyday routine and standard care. The primary endpoint was the change in physical performance measured by the short physical performance battery (SPPB, score range 0-12). The secondary endpoints were changes in handgrip strength, independence in BADL measured by the Barthel index (BI), and the rate of falls. The exercise intervention significantly provided benefits over usual care on SPPB score by 2.59 points (95% CI: 1.75, 3.43) and handgrip strength by 1.85 kgf (95% CI: 0.56, 3.14). No significant between-group differences were observed for the BI or the rate of falls. However, within-group analysis revealed a significant decline in the BI score (- 11.8) and an increase in the rate of falls (+ 31.5 falls per 100 person-years) in the usual care group. Long-term concurrent exercise programme significantly improved physical performance and handgrip strength, but not independence in BADL and rate of falls in mostly frail nursing home residents. These findings support the integration of exercise physiologists and exercise programmes into standard care practices in nursing homes to help preserve physical function among residents.","PeriodicalId":12730,"journal":{"name":"GeroScience","volume":"38 1","pages":""},"PeriodicalIF":5.6,"publicationDate":"2025-07-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144639952","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Optimizing Statin Therapy in Older Adults: A Systematic Review of Dosing, Titration, and Combination Strategies.","authors":"Anna Artner,Romána Zelkó,Balázs Hankó","doi":"10.1007/s11357-025-01772-w","DOIUrl":"https://doi.org/10.1007/s11357-025-01772-w","url":null,"abstract":"Statins are crucial in lipid-lowering therapy for reducing atherosclerotic cardiovascular disease (ASCVD) risk. However, rhabdomyolysis, a rare but severe side effect, disproportionately affects frail, older adults with polypharmacy and multiple comorbidities. Current guidelines for adjusting statin dosages in older adults lack clarity. To evaluate statin use in the geriatric population, assess benefit-risk ratios, and analyze dosage regimens through a systematic literature review. A comprehensive search was conducted in PubMed, Scopus, Web of Science, and EBSCO databases. Eleven original studies involving 566,509 patients were included. The review was registered on PROSPERO (CRD42024587259). Statin therapy was associated with a lower risk of cardiovascular disease compared to placebo. When adjusted during treatment, higher-intensity statins appeared to provide greater benefits than fixed low-dose statins, while the likelihood of side effects remained similar. Using ezetimibe and statins further improved outcomes and was linked to fewer side effects. Adherence-improving techniques were crucial, especially in older adults. Individualized statin dosing, considering titration, combination therapy, and adherence strategies, is essential for maximizing benefits and minimizing risks in older adults. While statins effectively reduce CVD risk, careful consideration of patient-specific factors is necessary when prescribing to older adults.","PeriodicalId":12730,"journal":{"name":"GeroScience","volume":"4 1","pages":""},"PeriodicalIF":5.6,"publicationDate":"2025-07-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144639953","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nicotinamide riboside treatment enhances stress sensitivity and modulates hematological dynamics in aged mice.","authors":"Luka Culig,Amogh Kashyap,Wakako Kuribayashi,Quia C Claybourne,Isabel Beerman","doi":"10.1007/s11357-025-01793-5","DOIUrl":"https://doi.org/10.1007/s11357-025-01793-5","url":null,"abstract":"Nicotinamide riboside (NR) is a precursor to NAD+, a vital molecule for cellular energy metabolism whose levels decline with age. Aging is associated with loss of cognitive and immune function, alterations in hematological parameters, and increased vulnerability to stress. Although NR supplementation can mitigate age-related declines, it remains uncertain whether these positive effects persist when the organism is exposed to chronic physiological stress. We investigated this by exposing aged mice to NR supplementation alongside daily physiological stress and assessed various indices before and after treatment. Our results revealed that 6 weeks of NR supplementation protected against stress-induced thrombocytopenia and increased the frequencies of B and T cells. However, NR also heightened stress sensitivity, as evidenced by increased anxiety-like behaviors, while not affecting cognitive function. These findings suggest a dual role for NR in potentially enhancing immune function while exacerbating behavioral responses to stress. Future research on NR should consider stress as a variable to optimize its therapeutic usage in aging populations.","PeriodicalId":12730,"journal":{"name":"GeroScience","volume":"30 1","pages":""},"PeriodicalIF":5.6,"publicationDate":"2025-07-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144640182","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Serum ACE2 activity as a novel biomarker of assessment of severe aortic stenosis.","authors":"Anita Kurczina,Arnold Péter Ráduly,Ivetta Mányiné Siket,Zsófia Pólik,Bertalan Kracskó,Attila Béla Kertész,Ágnes Balogh,Andrea Molnár,Tibor Fülöp,Laura Antal,Csaba Ötvös,Miklós Fagyas,Tamás Szerafin,Attila Tóth,Zoltán Papp,Zoltán Csanádi,Attila Borbély","doi":"10.1007/s11357-025-01792-6","DOIUrl":"https://doi.org/10.1007/s11357-025-01792-6","url":null,"abstract":"Aortic stenosis (AS) is the most prevalent valve disease in developed countries, with its incidence rising in the aging population. The current criteria for aortic valve replacement (AVR) are based on subjective symptoms and left ventricular ejection fraction (LVEF), which may not adequately reflect left ventricular (LV) dysfunction. This highlights the necessity for objective biomarkers to evaluate subclinical LV dysfunction. Serum angiotensin-converting enzyme 2 (sACE2) has emerged as a promising novel biomarker for cardiovascular diseases. To investigate the association between sACE2 activity and different flow-grade categories of severe AS, compare it with the traditional biomarker N-terminal pro-brain natriuretic peptide (NT-proBNP), and assess the utility of sACE2 as a biomarker for AS. sACE2 and NT-proBNP were measured in 175 patients (97 male, 78 female, mean age 75 ± 8 years) diagnosed with severe AS (aortic valve area, AVA ≤ 1 cm2). Patients were classified into 5 groups depending on LV flow state and pressure gradient levels: normal flow-low gradient (NF-LG), normal flow-high gradient (NF-HG), low flow-high gradient (LF-HG), low flow-low gradient (LF-LG), and paradoxical low flow-low gradient (PLF-LG) AS. Both biomarkers showed a general increase with advanced stages of severe AS (NF-LG: 65.0 ± 3.5 U/ml; LF-LG: 148.1 ± 16.8 U/ml; P < 0.05 for sACE2 and NF-LG: 687 ± 193 pg/ml; LF-LG: 5966 ± 1076 pg/ml; P < 0.05 for NT-proBNP). Notably, PLF-LG patients exhibited NT-proBNP levels similar to NF groups (PLF-LG: 1010 ± 218 pg/ml). Both biomarkers negatively correlated with LVEF and AVA. Receiver operating characteristic (ROC) analysis revealed that sACE2 provides incremental value over NT-proBNP in detecting subclinical LV dysfunction, with a 44% specificity for sACE2 compared to 6% for NT-proBNP at 98,67% sensitivity. The assessment of sACE2 activity in patients with AS provides valuable insights into disease stage and progression, supporting clinical decision-making and optimizing the timing of AVR. Furthermore, sACE2 activity serves as a moderately sensitive blood biomarker for identifying patients at risk of AS.","PeriodicalId":12730,"journal":{"name":"GeroScience","volume":"16 1","pages":""},"PeriodicalIF":5.6,"publicationDate":"2025-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144639956","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}