GeroScience最新文献

{"title":"A tongue resistance training program improves strength, endurance, and swallowing in frail older adults with mild cognitive impairment: a double-blind randomized controlled trial.","authors":"Shu-Hua Kao, Ruey Chen, Pi-Yu Su, Kondwani Joseph Banda, Chien-Mei Sung, Chia-Hui Wang, Kai-Jo Chiang, Melati Fajarini, Kuei-Ru Chou","doi":"10.1007/s11357-025-01715-5","DOIUrl":"10.1007/s11357-025-01715-5","url":null,"abstract":"<p><strong>Background: </strong>Age-associated decline in swallowing and tongue function is associated with mild cognitive impairment (MCI) and frailty. However, evidence regarding effectiveness of tongue resistance exercises in frail older adults with MCI is limited with methodological variations and lack of follow-up.</p><p><strong>Objective: </strong>To determine the effectiveness of a tongue resistance training program (TRTP) in improving tongue strength (anterior tongue strength [ATS] and posterior tongue strength [PTS]), tongue endurance (anterior tongue endurance [ATE] and posterior tongue endurance [PTE]), and swallowing pressure (saliva swallowing pressure [SSP] and effortful swallowing pressure [ESP]) in frail older adults with MCI.</p><p><strong>Methods: </strong>A prospective, double-blind, randomized controlled trial design. Participants were randomly assigned to TRTP (n = 23) or cheek-bulging exercises (n = 23). Generalized estimating equation model involving intention-to-treat approach was used for data analysis.</p><p><strong>Results: </strong>A total of 46 frail older adults with MCI were recruited (women: 80.0%; mean age: 75.7 ± 6.7 years). TRTP significantly improved ATS (β = 6.4; p = 0.016, 95%CI = 1.2-11.5), SSP (β = 12.5; p < 0.001, 95%CI = 9.2-15.9), and ESP (β = 14.2; p < 0.001, 95%CI = 9.3-19.0) at immediate posttest. However, no significant improvements were observed for PTS (β = 4.0; p = 0.231, 95%CI =  - 2.6-10.6), ATE (β =  - 4.5; p = 0.173, 95%CI =  - 10.9-2.0), and PTE (β = 2.4; p = 0.489, 95%CI =  - 4.5-9.4). At 12-week follow-up, sustained improvements were observed for SSP (β = 6.1; p < 0.001, 95%CI = 2.6-9.7) and ESP (β = 7.9; p < 0.001, 95%CI = 3.9-11.9). No significant short-term effects on ATS, PTS, ATE, and PTE (p > 0.05).</p><p><strong>Conclusion: </strong>TRTP effectively improved ATS, SSP, and ESP in frail older adults with MCI. Future research should integrate progressive resistance exercises sustained isometric and isokinetic exercises, and task-specific training. Trial Registration Clincialtrials.gov: NCT06766487(2024.12.02).</p>","PeriodicalId":12730,"journal":{"name":"GeroScience","volume":" ","pages":""},"PeriodicalIF":5.3,"publicationDate":"2025-05-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144173709","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Functional characterisation of rare variants in genes encoding the MAPK/ERK signalling pathway identified in long-lived Leiden Longevity Study participants.","authors":"Maarouf Baghdadi, Helena Hinterding, Thies Gehrmann, Pasquale Putter, Mara Neuerburg, Nico Lakenberg, Erik B van den Akker, P Eline Slagboom, Joris Deelen, Linda Partridge","doi":"10.1007/s11357-025-01699-2","DOIUrl":"https://doi.org/10.1007/s11357-025-01699-2","url":null,"abstract":"<p><p>Human longevity, which is coupled to compression of age-related disease, is a heritable trait. However, only few common genetic variants have been linked to longevity, suggesting that rare, family-specific variants may also play a role. We therefore investigated whole-genome sequencing data of long-lived individuals from the Leiden Longevity Study and identified family-specific variants residing in genes involved in the mitogen-activated protein kinase (MAPK) cascade, a lifespan-associated and evolutionarily conserved pathway emerging from studies in model organisms. We subsequently generated and functionally characterised mouse embryonic stem cells (mESCs) harbouring these variants. Two variants, located in NF1 (Phe1112Leu) and RAF1 (Asp633Tyr), reduce MAPK/extracellular signal-regulated kinase (ERK) signalling pathway activity in mESCs. At the proteomic and transcriptomic level, we observed prominent changes that were shared (e.g. upregulation of ribosomal proteins and Foxo3 expression) and opposing between the variants (e.g. downregulation of mTORC1 signalling-related proteins and Ets2 expression in the RAF1^Asp633Tyr variant cell line versus upregulation in the NF1^Phe1112Leu variant cell lines). These changes were accompanied by opposing effects on proliferation. Moreover, the RAF1^Asp633Tyr variant improved resistance to replication stress, while this was not the case for the NF1^Phe1112Leu variant. In conclusion, we identified two rare genetic variants in long-lived families that influence MAPK/ERK signalling in a manner that has previously been linked to increased lifespan in model organisms. Our findings suggest that mESCs offer a suitable starting point for studying rare genetic variants linked to human longevity, allowing for the identification of promising variants to pursue in in vivo studies using model organism.</p>","PeriodicalId":12730,"journal":{"name":"GeroScience","volume":" ","pages":""},"PeriodicalIF":5.3,"publicationDate":"2025-05-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144179676","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Olfactory dysfunction increases progression to dementia in cognitively impaired older adults: a 12-year population-based study.","authors":"Javier Oltra, Ingrid Ekström, Maria Larsson, Jane Yan, Giulia Grande, Erika J Laukka","doi":"10.1007/s11357-025-01705-7","DOIUrl":"https://doi.org/10.1007/s11357-025-01705-7","url":null,"abstract":"<p><p>Olfactory deficits are hypothesized to precede cognitive decline and be independently associated with future dementia. Conversely, the concurrency of cognitive and olfactory impairments is expected to represent an advanced stage, associated with shorter time to diagnosis. Limited research has examined the association of isolated and concurrent cognitive and olfactory impairments with incident dementia. We aimed to estimate the 12-year dementia hazard for cognitive impairment no dementia (CIND), olfactory dysfunction (OD), and their combination in a population-based cohort of older adults. We classified 2406 participants from the Swedish National Study on Aging and Care in Kungsholmen (SNAC-K) based on baseline CIND and OD. Dementia hazard was estimated with Cox regressions for the whole period and two timeframes (baseline to 6-year follow-up and 6- to 12-year follow-up), and time until receiving a diagnosis via Laplace regressions. CIND+OD was associated with increased hazard ratio (HR) of dementia over 6 years (HR 11.38; 95% CI 6.70, 19.32; p < 0.001), higher for amnestic CIND+OD (HR 22.23; 95% CI 11.79, 41.90; p < 0.001). Isolated CIND was associated with dementia closest to baseline (HR 3.38; 95% CI 1.75, 6.49; p < 0.001), while isolated OD was associated with dementia closest (HR 2.56; 95% CI 1.48, 4.43; p < 0.001) and furthest (HR 2.12; 95% CI 1.41, 3.19; p < 0.001) to baseline. CIND+OD received their dementia diagnosis 3 years earlier. This study demonstrated that individuals with both cognitive and olfactory impairments have a higher short-term risk of progression to dementia and that OD may be a valuable early marker of dementia on its own.</p>","PeriodicalId":12730,"journal":{"name":"GeroScience","volume":" ","pages":""},"PeriodicalIF":5.3,"publicationDate":"2025-05-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144173712","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of electrical muscle stimulation on cognitive function and neuropathology in senescence-accelerated mouse (SAMP8) model of aging-associated cognitive decline.","authors":"Hanlin Jiang, Tingrui Zhao, Chunxiao He, Bin Liu, Wanlin Ai, Yuxin Chen, Hideki Moriyama","doi":"10.1007/s11357-025-01717-3","DOIUrl":"https://doi.org/10.1007/s11357-025-01717-3","url":null,"abstract":"<p><p>The global increase in aging populations has heightened the urgency to develop effective interventions for age-related cognitive decline. Skeletal muscle has recently emerged as a potential modulator of brain health, particularly in the context of aging. This study investigates the effects of electrical muscle stimulation (EMS) on cognitive function and neuropathology in Senescence-Accelerated Mouse (SAMP8), a model of aging-associated cognitive decline. SAMP8 mice were divided into 3 groups: healthy controls (SAMR1), untreated SAMP8, and EMS-treated SAMP8. EMS was applied daily for 30 days, and behavioral, histological, and molecular markers were analyzed. Results demonstrated that EMS significantly improved muscle strength and endurance while reducing amyloid-β accumulation and phosphorylated tau (p-Tau) levels in the hippocampus. Furthermore, EMS decreased neuroinflammation and partially restored synaptic plasticity. However, EMS had limited effects on cortical pathology and cognitive function, suggesting that localized brain changes may not fully translate to behavioral improvements. These findings indicate that EMS exerts neuroprotective effects through skeletal muscle activation, providing a potential non-pharmacological intervention for age-related neurodegeneration. Future studies should explore the underlying mechanisms and translational applicability to human dementia treatment.</p>","PeriodicalId":12730,"journal":{"name":"GeroScience","volume":" ","pages":""},"PeriodicalIF":5.3,"publicationDate":"2025-05-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144173710","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Tilorone attenuates high-fat diet-induced hepatic steatosis by enhancing BMP9-Smad1/5/8 signaling.","authors":"Barnabas Horvath,Judit Halasz,Norman Noel Tanner,Zoltan Marton Kohler,Gyorgy Trencsenyi,Laszlo Juhasz,Laszlo Rovo,Andras Kiss,Aniko Keller-Pinter","doi":"10.1007/s11357-025-01685-8","DOIUrl":"https://doi.org/10.1007/s11357-025-01685-8","url":null,"abstract":"The prevalence of metabolic dysfunction-associated steatotic liver disease (MASLD) is rapidly increasing and is caused by excessive fat deposition in the liver due to non-alcoholic factors. Aging is a major risk factor for the development and progression of MASLD. In this study, we investigated the metabolic effects of tilorone, a synthetic small molecule, in a high-fat diet (HFD) mouse model, with a focus on the liver function and signaling. We demonstrate that tilorone attenuated HFD-induced steatosis by restoring bone morphogenetic protein 9 (BMP9)-Smad1/5/8 signaling and upregulating peroxisome proliferator-activated receptor gamma (PPARγ) expression. Tilorone reduced HFD-induced increases in body weight, adipose tissue and liver weight, and blood glucose levels, and improved glucose tolerance in HFD mice. PET/MRI imaging demonstrated enhanced 18FDG (18F-fluoro-2-deoxyglucose) uptake in liver, skeletal muscle, adipose tissue, and myocardium of tilorone-treated HFD animals. Histological analysis showed that tilorone reduced the HFD-induced diffuse, macrovesicular steatosis (S3/3), and machine learning-based image analysis revealed a decrease in lipid droplet size and lipid content. HFD caused the disappearance of liver glycogen, but tilorone increased glycogen levels. High-resolution respirometry indicated that tilorone reduced HFD-induced increases in mitochondrial complex II-linked oxidative phosphorylation and complex IV activity. These findings revealed the beneficial effects of tilorone on HFD and highlight its therapeutic potential in MASLD, particularly given that tilorone is a synthetic small molecule and can be administered orally. Further studies are required to explore its clinical application.","PeriodicalId":12730,"journal":{"name":"GeroScience","volume":"132 1","pages":""},"PeriodicalIF":5.6,"publicationDate":"2025-05-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144146179","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Geroprotective applications of oleuropein and hydroxytyrosol through the hallmarks of ageing.","authors":"Anna Calabrò, Anna Aiello, Paula Silva, Calogero Caruso, Giuseppina Candore, Giulia Accardi","doi":"10.1007/s11357-025-01697-4","DOIUrl":"https://doi.org/10.1007/s11357-025-01697-4","url":null,"abstract":"<p><p>Geroprotectors are compounds that target the underlying mechanisms of ageing to delay the onset of age-related diseases and extend both lifespan and health span. As ageing is driven by the accumulation of cellular damage, DNA instability, epigenetic changes, mitochondrial dysfunction, and chronic inflammation, the concept of geroprotection focuses on compounds that can mitigate these processes. Oleuropein (OLE) and its derivative hydroxytyrosol (HT), both phenolic molecules derived from Olea europaea (olive tree), have gained significant attention as potential geroprotectors due to their potent antioxidant and anti-inflammatory properties. These phytochemicals, central to the Mediterranean diet, activate key molecular pathways such as nuclear factor erythroid 2-related factor 2, reducing oxidative stress and modulating inflammatory responses. Through these mechanisms, OLE and HT help counteract inflammageing, a critical factor in age-related dysfunction. This review highlights the role of OLE and HT as geroprotective agents, emphasising their ability to target the hallmarks of ageing and their potential to improve health span by slowing the progression of age-related conditions. With proven efficacy in various biological models, these compounds represent promising tools in the ongoing search for strategies to enhance the quality of life in ageing populations.</p>","PeriodicalId":12730,"journal":{"name":"GeroScience","volume":" ","pages":""},"PeriodicalIF":5.3,"publicationDate":"2025-05-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144158227","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of aerobic exercise and cardiorespiratory fitness on white matter free water fraction in older adults: a 1-year randomized controlled trial.","authors":"Takashi Tarumi,Junyeon Won,Tsubasa Tomoto,Norman Scheel,David C Zhu,John Ashley,Karen M Rodrigue,Kristen M Kennedy,Denise C Park,Rong Zhang","doi":"10.1007/s11357-025-01709-3","DOIUrl":"https://doi.org/10.1007/s11357-025-01709-3","url":null,"abstract":"Free water fraction (FWF), derived from diffusion MRI, is a sensitive biomarker of white matter microstructure and may be modifiable through lifestyle interventions. The mid-anterior corpus callosum (CC) has been proposed as particularly responsive to physical exercise and the related increases in cardiorespiratory fitness. This study examined the effects of aerobic exercise training and fitness on FWF in the CC and on cognitive performance in older adults. Seventy-three participants (mean age 69 ± 5 years, 77% women) were randomized to a 1-year aerobic training or stretching intervention. FWF was assessed using diffusion tensor MRI, fitness via maximal oxygen uptake (VO2max), and cognition using a composite score of reasoning, memory, and processing speed. Linear mixed models revealed a significant increase in VO2max following aerobic training compared to stretching, while cognitive performance improved in both groups. A significant region × group × time interaction was observed for FWF, although Bonferroni-corrected pairwise comparisons showed no significant group difference. However, complete-case analysis of the mid-anterior CC showed a significant FWF reduction in the CC body following aerobic training compared to stretching (- 2.71 ± 5.44% vs. 0.63 ± 6.42%, p = 0.048). Tract-based spatial statistics indicated that lower baseline VO2max predicted greater FWF increases in the CC body and genu across groups. Baseline FWF was negatively correlated with cognitive performance. These findings suggest that 1 year of aerobic training may reduce FWF in the CC body and that higher physical fitness preserves white matter microstructure and support cognitive health in older adults.","PeriodicalId":12730,"journal":{"name":"GeroScience","volume":"23 1","pages":""},"PeriodicalIF":5.6,"publicationDate":"2025-05-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144136658","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Loss of microstructural integrity in left hemispheric white matter tracts is associated with poorer digits in noise understanding.","authors":"Jordi H C Boons,Gertjan Dingemanse,Elisabeth J Vinke,Bernd Kremer,Meike W Vernooij,André Goedegebure","doi":"10.1007/s11357-025-01707-5","DOIUrl":"https://doi.org/10.1007/s11357-025-01707-5","url":null,"abstract":"Age-related hearing loss (ARHL) is a prevalent condition among older adults and is regarded as a potentially modifiable risk factor for dementia. Although multiple studies have investigated pure-tone thresholds as a measure for ARHL and its relationship to dementia, the potential role of the central auditory system has received little attention. To address this gap in the literature, this study investigates the relationship between central auditory functioning, assessed using the speech-reception-threshold (SRT) of the digits-in-noise (DIN) test, and the microstructural integrity of white matter tracts in the Rotterdam Study. A total of 1669 participants underwent the DIN test and had diffusion imaging data available. The SRT was found to be significantly associated with the microstructural integrity of the left inferior fronto-occipital fasciculus, inferior longitudinal fasciculus, and posterior thalamic radiation. After accounting for audibility effects, the association with the inferior fronto-occipital fasciculus and the inferior longitudinal fasciculus was even stronger, while the association with the posterior thalamic radiation was no longer significant. These findings suggest that age-related declines in specific brain regions may contribute to difficulties in speech-in-noise understanding among the elderly.","PeriodicalId":12730,"journal":{"name":"GeroScience","volume":"139 1","pages":""},"PeriodicalIF":5.6,"publicationDate":"2025-05-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144136659","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cognitive and neuroimaging outcome of very prodromal dementia with Lewy bodies.","authors":"Frédéric Blanc,Vincent Bouteloup,Claire Paquet,Marie Chupin,Florence Pasquier,Audrey Gabelle,Mathieu Ceccaldi,Paulo Loureiro de Sousa,Pierre Krolak-Salmon,Renaud David,Clara Fischer,Jean-François Dartigues,David Wallon,Olivier Moreaud,Mathilde Sauvée,Catherine Belin,Claire Roubaud,Anne Botzung,Alix Ravier,Catherine Demuynck,Izzie Namer,Marie-Odile Habert,Olivier Bousiges,Benoît Schorr,Candice Muller,Nathalie Philippi,Geneviève Chêne,Benjamin Cretin,Jean-François Mangin,Carole Dufouil","doi":"10.1007/s11357-025-01701-x","DOIUrl":"https://doi.org/10.1007/s11357-025-01701-x","url":null,"abstract":"The cognitive and neuroimaging evolution over the course of dementia with Lewy bodies (DLB) from prodromal stage - Pro-DLB (subjective (SCI) to mild cognitive impairment (MCI)) - is poorly understood. The aim of this study was to analyze from 5-year longitudinal data the trajectories of Pro-DLB patients. The \"Lewy- MEMENTO\" prospective clinical cohort recruited 773 patients for either SCI or MCI. The Pro-DLB group was compared to a group with prodromal Alzheimer's disease (Pro-AD), a group with \"prodromal DLB and AD\" (Pro-DLB + AD), and a group without prodromal DLB and AD (no symptom [NS]). We modeled the 5-year evolution of cognitive functions and the 2-year evolution of brain MRI volumetry on MRI and brain metabolism (FDG PET). The Pro-AD and Pro-DLB + AD groups had more cognitive and functional decline than the Pro-DLB and NS groups (P < .001). The Pro-DLB group had more cognitive decline than the NS group (P < .004). Incident dementia during the follow-up was higher in the Pro-AD (13.0 per 100 person-years) and Pro-DLB + AD (10.3) groups than in the Pro-DLB (1.02) and NS (0.44) groups (P < .001). The decline in the metabolism of the left orbitofrontal cortex was greater in the Pro-DLB + AD group. The volume decrease of hippocampi, entorhinal cortices, amygdalae, and left insula was higher in the Pro-AD and the pro-DLB + AD groups. Patients in the pro-DLB group had less cognitive, functional, brain volume, and metabolism decrease than patients in the Pro-AD and pro-DLB + AD groups. DLB would therefore be a less degenerative and more dysfunctional disease at the prodromal stage.","PeriodicalId":12730,"journal":{"name":"GeroScience","volume":"34 1","pages":""},"PeriodicalIF":5.6,"publicationDate":"2025-05-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144136710","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sensory impairments and epigenetic aging: insights from self-rated hearing and vision in United States adults","authors":"Jamaji C. Nwanaji-Enwerem, Dennis Khodasevich, Nicole Gladish, Hanyang Shen, Anne K. Bozack, Saher Daredia, Belinda L. Needham, David H. Rehkopf, Andres Cardenas","doi":"10.1007/s11357-025-01706-6","DOIUrl":"https://doi.org/10.1007/s11357-025-01706-6","url":null,"abstract":"<p>Sensory impairments are common with aging, but studies examining the relationships of these impairments with DNA methylation–based biomarkers of aging, strong predictors of morbidity and mortality, remain sparse. We investigated whether subjective measures of sensory impairment are associated with epigenetic age biomarkers. We conducted a cross-sectional analysis in a representative sample of 2344 U.S. adults from the 1999–2000 and 2001–2002 cycles of the National Health and Nutrition Examination Survey (NHANES). We examined the relationships of self-rated auditory and vision function with seven epigenetic aging biomarkers: HannumAge, HorvathAge, SkinBloodAge, PhenoAge, GrimAge2, DNA methylation telomere length, and DunedinPoAm. We adjusted for potential confounders including chronological age, other demographics, lifestyle factors, and general health. In adjusted survey-weighted models, self-reported deafness was associated with a significantly higher GrimAge2 (<i>β</i> = 4.19-years, 95% CI 2.29, 6.09, <i>P</i> = 0.004) and DunedinPoAm (<i>β</i> = 0.07, 95% CI 0.04, 0.09, <i>P</i> = 0.002) compared to good hearing. Deafness was also associated with significantly higher GrimAge2 estimates of TIMP1 (<i>β</i> = 459.51, 95% CI 287.00, 632.03 <i>P</i> = 0.002) and marginally higher estimated levels of ADM (<i>β</i> = 10.06, 95% CI 1.76, 18.36, <i>P</i> = 0.03), CRP (<i>β</i> = 0.34, 95% CI 0.11, 0.56, <i>P</i> = 0.01), and cigarette pack-years (<i>β</i> = 6.55, 95% CI 2.62, 10.47, <i>P</i> = 0.01). No associations were observed with self-rated vision. We describe associations of self-rated deafness with accelerated epigenetic aging, as measured by GrimAge2 and DunedinPoAm. These results provide a foundation for future research exploring epigenetic biomarkers as tools for predicting and understanding the biological processes underlying sensory impairments like deafness.</p>","PeriodicalId":12730,"journal":{"name":"GeroScience","volume":"46 1","pages":""},"PeriodicalIF":5.6,"publicationDate":"2025-05-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144123019","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}