GeroScience最新文献

{"title":"Role for neurological and immunological resilience in the pathway of the aging muscle powerpenia: InCHIANTI study longitudinal results.","authors":"Raffaello Pellegrino, Roberto Paganelli, Angelo Di Iorio, Matteo Candeloro, Stefano Volpato, Stefania Bandinelli, Antimo Moretti, Giovanni Iolascon, Toshiko Tanaka, Luigi Ferrucci","doi":"10.1007/s11357-025-01536-6","DOIUrl":"10.1007/s11357-025-01536-6","url":null,"abstract":"<p><p>The neuromuscular junction shows several degenerative changes with aging, resulting in a reduction of transmission efficacy. These changes, paired with low-grade chronic inflammation, were considered triggers of the aging muscle processes. The main objective of this study is to assess the role of leukocyte count-derived ratios, nerve conduction velocity (NCV), and compound muscle action potential (CMAP) in determining time-dependent reduction in lower limb muscle explosive strength, a condition that has been defined as powerpenia. The InCHIANTI study enrolled a representative sample from the registry lists of two towns in Tuscany, Italy. Baseline data were collected in 1998, with follow-up visits every 3 years. For the purpose of this analysis, we used 1229 subjects and 3814 follow-up assessments. Subjects with lower values of monocyte-to-lymphocyte ratio (ML-ratio) had higher nerve conduction velocity and higher proximal and distal action potential values; moreover, considering the interaction between age for ML-ratio effect, a statistically significant direct association is found with all the electromyography-parameters. Lower limb muscle power shows a gender dimorphism, male subjects having higher values at baseline, but experiencing steeper decline rate during the follow-up, compared to females. Muscle power was inversely associated with ML-ratio, proximal CMAP, distal CMAP, and NCV. Moreover, we found a direct and statistically significant second-order interaction (age for ML-ratio), meaning that at the same age, increasing ML-ratio increases lower limb muscle power. Lastly, also body composition variation across aging is directly associated with lower limb muscle power. Reduced immunological and neurological homeostasis affects the powerpenia phenotype in a large representative sample of Italian men and women.</p>","PeriodicalId":12730,"journal":{"name":"GeroScience","volume":" ","pages":"5591-5604"},"PeriodicalIF":5.4,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12397046/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143064791","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction to: Lifespan effects in male UM‑HET3 mice treated with sodium thiosulfate, 16‑hydroxyestriol, and late‑start canagliflozin.","authors":"Richard A Miller, David E Harrison, Gino A Cortopassi, Ishmael Dehghan, Elizabeth Fernandez, Michael Garratt, John G Geisler, Brett C Ginsburg, Melissa L Han, Nisi Jiang, Catherine C Kaczorowski, Navasuja Kumar, Scott F Leiser, Marisa Lopez-Cruzan, Ginger Milne, James R Mitchell, James F Nelson, Peter C Reifsnyder, Adam B Salmon, Ziying Xu, Ron Korstanje, Nadia Rosenthal, Randy Strong","doi":"10.1007/s11357-024-01283-0","DOIUrl":"10.1007/s11357-024-01283-0","url":null,"abstract":"","PeriodicalId":12730,"journal":{"name":"GeroScience","volume":" ","pages":"6093-6094"},"PeriodicalIF":5.4,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12397457/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141616258","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction to: Cognitive frailty and functional disability in older adults: A 10‑year prospective cohort study in Japan.","authors":"Sanmei Chen, Tao Chen, Takanori Honda, Hiro Kishimoto, Yu Nofuji, Kenji Narazaki","doi":"10.1007/s11357-025-01618-5","DOIUrl":"10.1007/s11357-025-01618-5","url":null,"abstract":"","PeriodicalId":12730,"journal":{"name":"GeroScience","volume":" ","pages":"6115-6116"},"PeriodicalIF":5.4,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12397020/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143729716","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dynamic proportional loss of functional connectivity revealed change of left superior frontal gyrus in subjective cognitive decline: an explanatory study based on Chinese and Western cohorts.","authors":"Luyao Wang, Wenjing Hu, Fan Dong, Can Sheng, Jinglong Wu, Ying Han, Jiehui Jiang, Michael W Weiner, Paul Aisen, Ronald Petersen, Clifford R Jack, William Jagust, John Q Trojanowski, Arthur W Toga, Laurel Beckett, Robert C Green, Andrew J Saykin, John Morris, Leslie M Shaw, Zaven Khachaturian, Greg Sorensen, Lew Kuller, Marcus Raichle, Steven Paul, Peter Davies, Howard Fillit, Franz Hefti, David Holtzman, Marek M Mesulam, William Potter, Peter Snyder, Adam Schwartz, Tom Montine, Ronald G Thomas, Michael Donohue, Sarah Walter, Devon Gessert, Tamie Sather, Gus Jiminez, Danielle Harvey, Matthew Bernstein, Paul Thompson, Norbert Schuff, Bret Borowski, Jeff Gunter, Matt Senjem, Prashanthi Vemuri, David Jones, Kejal Kantarci, Chad Ward, Robert A Koeppe, Norm Foster, Eric M Reiman, Kewei Chen, Chet Mathis, Susan Landau, Nigel J Cairns, Erin Householder, Lisa Taylor-Reinwald, Virginia Lee, Magdalena Korecka, Michal Figurski, Karen Crawford, Scott Neu, Tatiana M Foroud, Steven G Potkin, Li Shen, Kelley Faber, Sungeun Kim, Kwangsik Nho, Leon Thal, Neil Buckholtz, Marylyn Albert, Richard Frank, John Hsiao, Jeffrey Kaye, Joseph Quinn, Betty Lind, Raina Carter, Sara Dolen, Lon S Schneider, Sonia Pawluczyk, Mauricio Beccera, Liberty Teodoro, Bryan M Spann, James Brewer, Helen Vanderswag, Adam Fleisher, Judith L Heidebrink, Joanne L Lord, Sara S Mason, Colleen S Albers, David Knopman, Kris Johnson, Rachelle S Doody, Javier Villanueva-Meyer, Munir Chowdhury, Susan Rountree, Mimi Dang, Yaakov Stern, Lawrence S Honig, Karen L Bell, Beau Ances, Maria Carroll, Sue Leon, Mark A Mintun, Stacy Schneider, Angela Oliver, Daniel Marson, Randall Griffith, David Clark, David Geldmacher, John Brockington, Erik Roberson, Hillel Grossman, Effie Mitsis, Leyla de Toledo-Morrell, Raj C Shah, Ranjan Duara, Daniel Varon, Maria T Greig, Peggy Roberts, Chiadi Onyike, Daniel D'Agostino, Stephanie Kielb, James E Galvin, Brittany Cerbone, Christina A Michel, Henry Rusinek, Mony J de Leon, Lidia Glodzik, Susan De Santi, PMurali Doraiswamy, Jeffrey R Petrella, Terence Z Wong, Steven E Arnold, Jason H Karlawish, David Wolk, Charles D Smith, Greg Jicha, Peter Hardy, Partha Sinha, Elizabeth Oates, Gary Conrad, Oscar L Lopez, MaryAnn Oakley, Donna M Simpson, Anton P Porsteinsson, Bonnie S Goldstein, Kim Martin, Kelly M Makino, MSaleem Ismail, Connie Brand, Ruth A Mulnard, Gaby Thai, Catherine McAdams-Ortiz, Kyle Womack, Dana Mathews, Mary Quiceno, Ramon Diaz-Arrastia, Richard King, Myron Weiner, Kristen Martin-Cook, Michael DeVous, Allan I Levey, James J Lah, Janet S Cellar, Jeffrey M Burns, Heather S Anderson, Russell H Swerdlow, Liana Apostolova, Kathleen Tingus, Ellen Woo, Daniel H S Silverman, Po H Lu, George Bartzokis, Neill R Graff-Radford, Francine Parfitt, Tracy Kendall, Heather Johnson, Martin R Farlow, Ann Marie Hake, Brandy R Matthews, Scott Herring, Cynthia Hunt, Christopher H van Dyck, Richard E Carson, Martha G MacAvoy, Howard Chertkow, Howard Bergman, Chris Hosein, Ging-Yuek Robin Hsiung, Howard Feldman, Benita Mudge, Michele Assaly, Charles Bernick, Donna Munic, Andrew Kertesz, John Rogers, Dick Trost, Diana Kerwin, Kristine Lipowski, Chuang-Kuo Wu, Nancy Johnson, Carl Sadowsky, Walter Martinez, Teresa Villena, Raymond Scott Turner, Kathleen Johnson, Brigid Reynolds, Reisa A Sperling, Keith A Johnson, Gad Marshall, Meghan Frey, Barton Lane, Allyson Rosen, Jared Tinklenberg, Marwan N Sabbagh, Christine M Belden, Sandra A Jacobson, Sherye A Sirrel, Neil Kowall, Ronald Killiany, Andrew E Budson, Alexander Norbash, Patricia Lynn Johnson, Joanne Allard, Alan Lerner, Paula Ogrocki, Leon Hudson, Evan Fletcher, Owen Carmichae, John Olichney, Charles DeCarli, Smita Kittur, Michael Borrie, T-Y Lee, Rob Bartha, Sterling Johnson, Sanjay Asthana, Cynthia M Carlsson, Adrian Preda, Dana Nguyen, Pierre Tariot, Stephanie Reeder, Vernice Bates, Horacio Capote, Michelle Rainka, Douglas W Scharre, Maria Kataki, Anahita Adeli, Earl A Zimmerman, Dzintra Celmins, Alice D Brown, Godfrey D Pearlson, Karen Blank, Karen Anderson, Robert B Santulli, Tamar J Kitzmiller, Eben S Schwartz, Kaycee M Sink, Jeff D Williamson, Pradeep Garg, Franklin Watkins, Brian R Ott, Henry Querfurth, Geoffrey Tremont, Stephen Salloway, Paul Malloy, Stephen Correia, Howard J Rosen, Bruce L Miller, Jacobo Mintzer, Kenneth Spicer, David Bachman, Stephen Pasternak, Irina Rachinsky, Dick Drost, Nunzio Pomara, Raymundo Hernando, Antero Sarrael, Susan K Schultz, Laura L Boles Ponto, Hyungsub Shim, Karen Elizabeth Smith, Norman Relkin, Gloria Chaing, Lisa Raudin, Amanda Smith, Kristin Fargher, Balebail Ashok Raj, Thomas Neylan, Jordan Grafman, Melissa Davis, Rosemary Morrison, Jacqueline Hayes, Shannon Finley, Karl Friedl, Debra Fleischman, Konstantinos Arfanakis, Olga James, Dino Massoglia, JJay Fruehling, Sandra Harding, Elaine R Peskind, Eric C Petrie, Gail Li, Jerome A Yesavage, Joy L Taylor, Ansgar J Furst","doi":"10.1007/s11357-025-01528-6","DOIUrl":"10.1007/s11357-025-01528-6","url":null,"abstract":"<p><p>Brain network dynamics have been extensively explored in patients with subjective cognitive decline (SCD). However, these studies are susceptible to individual differences, scanning parameters, and other confounding factors. Therefore, how to reveal subtle SCD-related subtle changes remains unclear. Cross-sectional and longitudinal resting-state functional magnetic resonance imaging data from both Chinese and Western populations were analyzed. We proposed a framework of dynamic proportional loss of functional connectivity (DPLFC). After its stability was validated, the optimal parameters were applied for the clinical diagnosis of SCD. DPLFC yielded a relatively high intraclass correlation coefficient. In particular, the DPLFC of the left superior frontal gyrus (SFG) progressively decreased along the Alzheimer's disease (AD) continuum. Compared with the traditional index, the DPLFC had better classification performance between cognitively normal controls and patients with SCD. Furthermore, DPLFC was related to Aβ deposition and scale scores. Patients with lower DPLFC values had a greater risk of cognitive decline. Decreased DPLFC in the left SFG may be a potential AD-related neuroimaging biomarker at an early stage.</p>","PeriodicalId":12730,"journal":{"name":"GeroScience","volume":" ","pages":"5619-5634"},"PeriodicalIF":5.4,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12397043/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143064621","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction to: Functional and vascular neuroimaging in maritime pilots with long‑term sleep disruption.","authors":"Lara J Mentink, Matthias J P van Osch, Leanne J Bakker, Marcel G M Olde Rikkert, Christian F Beckmann, Jurgen A H R Claassen, Koen V Haak","doi":"10.1007/s11357-025-01617-6","DOIUrl":"10.1007/s11357-025-01617-6","url":null,"abstract":"","PeriodicalId":12730,"journal":{"name":"GeroScience","volume":" ","pages":"6113-6114"},"PeriodicalIF":5.4,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12397040/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144013705","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"An mTOR inhibitor discovery system using drug-sensitized yeast.","authors":"Anna K Breen, Sarah Thomas, David Beckett, Matthew Agsalud, Graham Gingras, Judd Williams, Brian M Wasko","doi":"10.1007/s11357-025-01534-8","DOIUrl":"10.1007/s11357-025-01534-8","url":null,"abstract":"<p><p>Inhibition of the target of rapamycin (TOR/mTOR) protein kinase by the drug rapamycin extends lifespan and health span across diverse species. However, rapamycin has potential off-target and side effects that warrant the discovery of additional TOR inhibitors. TOR was initially discovered in Saccharomyces cerevisiae (yeast) which contains two TOR paralogs, TOR1 and TOR2. Yeast lacking functional Tor1 are viable but are hypersensitive to growth inhibition by TORC1 inhibitors, which is a property of yeast that can be exploited to identify TOR inhibitors. Additionally, yeast lacking FK506-sensitive proline rotamase (FPR1) or containing a tor1-1 allele (a mutation in the Fpr1-rapamycin binding domain of Tor1) are robustly and selectively resistant to rapamycin and analogs that allosterically inhibit TOR activity via an FPR1-dependent mechanism. To facilitate the identification of TOR inhibitors, we generated a panel of yeast strains with mutations in TOR pathway genes combined with the removal of 12 additional genes involved in drug efflux. This creates a drug-sensitive strain background that can sensitively and effectively identify TOR inhibitors. In a wild-type yeast strain background, 25 µM of Torin1 and 100 µM of GSK2126458 (omipalisib) are necessary to observe TOR1-dependent growth inhibition by these known TOR inhibitors. In contrast, 100 nM Torin1 and 500 nM GSK2126458 (omipalisib) are sufficient to identify TOR1-dependent growth inhibition in the drug-sensitized background. This represents a 200-fold and 250-fold increase in detection sensitivity for Torin1 and GSK2126458, respectively. Additionally, for the TOR inhibitor AZD8055, the drug-sensitive system resolves that the compound results in TOR1-dependent growth sensitivity at 100 µM, whereas no growth inhibition is observed in a wild-type yeast strain background. Our platform also identifies the caffeine analog aminophylline as a TOR1-dependent growth inhibitor via selective tor1 growth sensitivity. We also tested nebivolol, isoliquiritigenin, canagliflozin, withaferin A, ganoderic acid A, and taurine and found no evidence for TOR inhibition using our yeast growth-based model. Our results demonstrate that this system is highly effective at identifying compounds that inhibit the TOR pathway. It offers a rapid, cost-efficient, and sensitive tool for drug discovery, with the potential to expedite the identification of new TOR inhibitors that could serve as geroprotective and/or anti-cancer agents.</p>","PeriodicalId":12730,"journal":{"name":"GeroScience","volume":" ","pages":"5605-5617"},"PeriodicalIF":5.4,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12397476/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143065265","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction to: The RESIST Senior Individuals Cohort: Design, participant characteristics and aims.","authors":"Lennart Matthias Roesner, Manoj Kumar Gupta, Verena Kopfnagel, Nienke van Unen, Yvonne Kemmling, Jana-Kristin Heise, Stephanie Castell, Xun Jiang, Lennart Riemann, Stephan Traidl, Berit Lange, Kurt-Wolfram Sühs, Thomas Illig, Till Strowig, Yang Li, Reinhold Förster, Jochen Huehn, Thomas Friedrich Schulz, Thomas Werfel","doi":"10.1007/s11357-024-01380-0","DOIUrl":"10.1007/s11357-024-01380-0","url":null,"abstract":"","PeriodicalId":12730,"journal":{"name":"GeroScience","volume":" ","pages":"6101-6102"},"PeriodicalIF":5.4,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12397005/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142463211","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction to: The efficacy of cognitive stimulation, cognitive training, and cognitive rehabilitation for people living with dementia: a systematic review and meta‑analysis.","authors":"Alice Paggetti, Ylenia Druda, Francesco Sciancalepore, Francesco Della Gatta, Antonio Ancidoni, Nicoletta Locuratolo, Paola Piscopo, Luca Vignatelli, Luciano Sagliocca, Antonio Guaita, Piero Secreto, Andrea Stracciari, Paolo Caffarra, Nicola Vanacore, Elisa Fabrizi, Eleonora Lacorte","doi":"10.1007/s11357-025-01551-7","DOIUrl":"10.1007/s11357-025-01551-7","url":null,"abstract":"","PeriodicalId":12730,"journal":{"name":"GeroScience","volume":" ","pages":"6111"},"PeriodicalIF":5.4,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12397029/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143255518","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction to: Anti-aging interventions in geriatric mice: insights into the timing of treatment, benefits, and limitations.","authors":"Marco Malavolta","doi":"10.1007/s11357-025-01587-9","DOIUrl":"10.1007/s11357-025-01587-9","url":null,"abstract":"","PeriodicalId":12730,"journal":{"name":"GeroScience","volume":" ","pages":"6125"},"PeriodicalIF":5.4,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12397051/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143565970","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of the acute effects of breaking up prolonged sitting time with single-task or a dual-task walking on cognitive function and cerebral blood flow in older adults: a randomized crossover trial.","authors":"Paolo M Cunha,Gustavo O Silva,Liye Zou,Max D Oliveira,Hélcio Kanegusuku,Qian Yu,Yanxia Chen,Zhihao Zhang,Fabian Herold,Ryan S Falck,Boris Cheval,Olivier Dupuy,Marilia A Correia,Nelson Wolosker,Raphael M Ritti-Dias","doi":"10.1007/s11357-025-01817-0","DOIUrl":"https://doi.org/10.1007/s11357-025-01817-0","url":null,"abstract":"This randomized cross-over study examined the acute effects of single-task or dual-task walking physical activity (PA) breaks of prolonged sitting among healthy older adults on cognitive performance and cerebral blood flow velocity (CBFv). Twenty-seven healthy older adults (69.4 ± 5.6 years, 25 female) were randomly assigned to engage in three experimental conditions (i.e., control, single-task, and dual-task walking), each one on a different day. All conditions included 3 h of sitting time, with a break every 30 min involving either 2 min of single-task or dual-task walking in the intervention conditions. In the control condition, the participants remained seated for 3 h without any breaks. Cognitive functioning (Trail Making Tests [TMT] A and B, Stroop test, and verbal fluency test) and CBFv were assessed before and 10 min after the cessation of the conditions, and their changes were analyzed with a Generalized Estimated Equation (GEE) model. A significant interaction effect was observed in Verbal Fluency phonological and semantic, and TMA (p < 0.01). It was found an effect size of 0.63 and 0.79 in phonological conditions for dual-task and single-task breaks, respectively. In addition, an effect size of 0.67 and 0.71 in semantic condition for dual-task and walking breaks, respectively, and for the TMA, it was found an effect size of - 0.22 for both break types. Furthermore, a significant improvement in CBFv was observed in the dual-task condition (ES = 0.91) and walking condition (ES = 0.55) (p < 0.05) compared to uninterrupted sitting. PA breaks of prolonged sitting by two different types of breaks are effective in improving verbal fluency and set-shifting performance and increasing the CBFv in older adults.","PeriodicalId":12730,"journal":{"name":"GeroScience","volume":"37 1","pages":""},"PeriodicalIF":5.6,"publicationDate":"2025-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144756120","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}