GeroScience最新文献

{"title":"The effect of frailty on the relationship between cognition and depression symptoms in older people. A differential analysis by European regions","authors":"Marcelo de Maio Nascimento, Andreas Ihle, Élvio Rúbio Gouveia, Ricardo Hugo Gonzalez, Adilson Marques","doi":"10.1007/s11357-024-01469-6","DOIUrl":"https://doi.org/10.1007/s11357-024-01469-6","url":null,"abstract":"<p>This study aimed to investigate the moderating effect of frailty on the relationship between cognition and symptoms of depression in individuals aged ≥65 and to explore differences between four European regions (West, North, South, and East). A cross-sectional analysis was conducted with 29,094 participants (16,365 women) from 27 countries, aged ≥65 years, who responded to wave 8 of the SHARE project. The variables analysed were depression (12-item EURO-D scale), frailty, and a general cognition index (CogId). A higher CogId was associated with less depression. Western and Northern European countries indicated better cognitive performance, lower depression symptomology, and frailty scores than those in the South and East. A pre-frail and frail status was a significant moderator, increasing the association between depression and cognition in the East, South, North, and West regions, respectively. The interaction effects between CogId and frailty were found in the West and East regions. Comparatively, the moderating role of frailty in countries in the Western region differed significantly from those in the North. In turn, countries in the South and East differed from those in the North region. Frailty was a moderator of depression symptoms, increasing its association with cognition. Strategies to prevent frailty are important to reduce the burden of depression and cognitive deficits in Europe.</p>","PeriodicalId":12730,"journal":{"name":"GeroScience","volume":"27 1","pages":""},"PeriodicalIF":5.6,"publicationDate":"2025-01-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142916983","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Complex genetic interactions affect susceptibility to Alzheimer's disease risk in the BIN1 and MS4A6A loci","authors":"Alireza Nazarian, Marissa Morado, Alexander M. Kulminski","doi":"10.1007/s11357-024-01477-6","DOIUrl":"https://doi.org/10.1007/s11357-024-01477-6","url":null,"abstract":"<p>Genetics is the second strongest risk factor for Alzheimer’s disease (AD) after age. More than 70 loci have been implicated in AD susceptibility so far, and the genetic architecture of AD entails both additive and nonadditive contributions from these loci. To better understand nonadditive impact of single-nucleotide polymorphisms (SNPs) on AD risk, we examined individual, joint, and interacting (SNPxSNP) effects of 139 and 66 SNPs mapped to the <i>BIN1</i> and <i>MS4A6A</i> AD-associated loci, respectively. The analyses were conducted by fitting three respective dominant allelic-effect models using data from four independent studies. Joint effects were analyzed by considering pairwise combinations of genotypes of the selected SNPs, i.e., compound genotypes (CompG). The individual SNP analyses showed associations of 18 <i>BIN1</i> SNPs and 4 <i>MS4A6A</i> SNPs with AD. We identified 589 <i>BIN1</i> and 217 <i>MS4A6A</i> SNP pairs associated with AD in the CompG analysis, although their individual SNPs were not linked to AD independently. Notably, 34 <i>BIN1</i> and 10 <i>MS4A6A</i> SNP pairs exhibited both significant SNPxSNP interaction effects and significant CompG effects. The vast majority of nonadditive effects were captured through the CompG analysis. These results expand the current understanding of the contributions of the <i>BIN1</i> and <i>MS4A6A</i> loci to AD susceptibility. The identified nonadditive effects suggest a significant genetic modulation mechanism underlying the genetic heterogeneity of AD in these loci. Our findings highlight the importance of considering nonadditive genetic impacts on AD risk beyond the traditional SNPxSNP approximation, as they may uncover critical mechanisms not apparent when examining SNPs individually.</p>","PeriodicalId":12730,"journal":{"name":"GeroScience","volume":"28 1","pages":""},"PeriodicalIF":5.6,"publicationDate":"2025-01-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142917284","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sex-specific mechanisms in vascular aging: exploring cellular and molecular pathways in the pathogenesis of age-related cardiovascular and cerebrovascular diseases","authors":"Anna Ungvari, Rafal Gulej, Roland Patai, Zoltan Papp, Attila Toth, Attila Á. Szabó, Bruno K. Podesser, Péter Sótonyi, Zoltán Benyó, Andriy Yabluchanskiy, Stefano Tarantini, Andrea B. Maier, Anna Csiszar, Zoltan Ungvari","doi":"10.1007/s11357-024-01489-2","DOIUrl":"https://doi.org/10.1007/s11357-024-01489-2","url":null,"abstract":"<p>Aging remains the foremost risk factor for cardiovascular and cerebrovascular diseases, surpassing traditional factors in epidemiological significance. This review elucidates the cellular and molecular mechanisms underlying vascular aging, with an emphasis on sex differences that influence disease progression and clinical outcomes in older adults. We discuss the convergence of aging processes at the macro- and microvascular levels and their contributions to the pathogenesis of vascular diseases. Critical analysis of both preclinical and clinical studies reveals significant sex-specific variations in these mechanisms, which could be pivotal in understanding the disparity in disease morbidity and mortality between sexes. The review highlights key molecular pathways, including oxidative stress, inflammation, and autophagy, and their differential roles in the vascular aging of males and females. We argue that recognizing these sex-specific differences is crucial for developing targeted therapeutic strategies aimed at preventing and managing age-related vascular pathologies. The implications for personalized medicine and potential areas for future research are also explored, emphasizing the need for a nuanced approach to the study and treatment of vascular aging.</p>","PeriodicalId":12730,"journal":{"name":"GeroScience","volume":"37 1","pages":""},"PeriodicalIF":5.6,"publicationDate":"2025-01-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142924552","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of physical activity and exercise training on health-related quality of life in older adults: an umbrella review","authors":"Beverly D. Schwartz, Haoxuan Liu, Emily E. MacDonald, Said Mekari, Myles W. O’Brien","doi":"10.1007/s11357-024-01493-6","DOIUrl":"https://doi.org/10.1007/s11357-024-01493-6","url":null,"abstract":"<p>Health-related quality of life (HRQoL) is inversely associated with all-cause mortality in older adults and may be improved with physical activity and exercise training. The objective of this umbrella review was to determine the impact of physical activity and exercise training on HRQoL in younger-old (average age ≤ 75 years) and older-old (average age &gt; 75 years) adults. Our umbrella review (CRD42023481145) included 39 systematic reviews (21/39 with meta-analysis) including 113 unique individual studies of 13391 unique participants. Sources were searched in November 2023 and included Scopus, EMBASE, PubMed, CINAHL, and Academic Search Premier. In all older adults, the impact of exercise/physical activity training on overall HRQoL (<i>n</i> = 30/39) demonstrated mixed results with 50% of studies observing an improvement in overall HRQoL following physical activity and exercise training (younger-old adults, 7/14 studies; older-old adults, 8/16 studies). Thirty-six percent and 44% of studies demonstrated no impact on HRQoL in younger-old and older-old adults, respectively. Fourteen percent and 6% of studies demonstrated mixed results in younger-old and older-old adults, respectively. Older-old adults had the greatest improvement in HRQoL following general exercise training (5/6 studies) versus interventions focusing on physical activity (4/8 studies). Younger-old adults had the greatest improvement in HRQoL following physical activity focused interventions (5/6 studies). Based on high-quality evidence and a large sample size, existing literature demonstrates that increasing physical activity in younger-old adults and general exercise training in older-old adults may be useful for improving HRQoL.</p>","PeriodicalId":12730,"journal":{"name":"GeroScience","volume":"88 1","pages":""},"PeriodicalIF":5.6,"publicationDate":"2025-01-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142924553","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The independent and combined associations of nocturnal sleep duration, sleep midpoint, and sleep onset latency with global cognitive function in older Chinese adults","authors":"Xueyao Wu, Jiaqiang Liao, Xin Chen, Jinyu Xiao, Xinyang Dui, Tianpei Ma, Lin Hu, Xunying Zhao, Qian Bu, Mengyu Fan, Tao Zhang, Lu Long, Xia Jiang, Ben Zhang, Jiayuan Li","doi":"10.1007/s11357-024-01476-7","DOIUrl":"https://doi.org/10.1007/s11357-024-01476-7","url":null,"abstract":"<p>This study aims to investigate the independent and combined associations of nocturnal sleep duration, sleep midpoint, and sleep onset latency with global cognitive function in older Chinese adults. Our cross-sectional study included 4601 community-dwelling cognitively unimpaired adults aged 60 years or older from the West China Health and Aging Cohort Study. Sleep characteristics were assessed using the Pittsburgh Sleep Quality Index, and global cognitive function was evaluated using the Mini-Mental State Examination (MMSE). Multivariable linear regression models were employed, adjusting for an extensive set of demographic, lifestyle, and comorbidity factors. Subgroup analyses were performed based on sex, age, and genetic risk profiles for cognitive performance. The mean age of participants was 69.0 ± 5.53 years, with 52.1% being female. The mean MMSE total score was 24.9 ± 3.20. Compared to the reference category for each sleep variable, sleep duration &lt; 5 h/day or &gt; 8 h/day, sleep midpoint earlier than 1:30 AM, and sleep latency &gt; 60 min were each independently associated with significantly lower MMSE scores (<i>β</i> range − 0.36 to − 0.34; 95% confidence interval range − 0.60 to − 0.10). A combined analysis revealed that individuals with concurrent extreme sleep duration, early midpoint, and/or long latency had even lower MMSE scores, especially among those with genetically predicted poorer cognitive performance (<i>β</i> up to − 1.86). Multiple dimensions of sleep are independently and jointly associated with global cognitive function in older Chinese adults, highlighting the importance of a holistic approach to sleep in cognitive aging research and interventions.</p>","PeriodicalId":12730,"journal":{"name":"GeroScience","volume":"41 1","pages":""},"PeriodicalIF":5.6,"publicationDate":"2025-01-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142917034","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Resistance training protects the hippocampus and precuneus against atrophy and benefits white matter integrity in older adults with mild cognitive impairment","authors":"Isadora C. Ribeiro, Camila V. L. Teixeira, Thiago J. R. de Resende, Brunno M. de Campos, Gabriel B. Silva, Marco C. Uchida, Thamires N. C. Magalhães, Luciana R. Pimentel-Silva, Ítalo K. Aventurato, Brenda C. Gonçalves, Marjorie C. R. da Silva, Liara Rizzi, Gustavo B. P. Fernandes, Paula T. Fernandes, Fernando Cendes, Marcio L. F. Balthazar","doi":"10.1007/s11357-024-01483-8","DOIUrl":"https://doi.org/10.1007/s11357-024-01483-8","url":null,"abstract":"<p>Mild cognitive impairment (MCI) refers to cognitive alterations with preservation of functionality. Individuals with this diagnosis have a higher risk of developing dementia. Non-pharmacological interventions, such as physical exercise, are beneficial for the cognition of this population. However, the impact of resistance training (RT) on the brain anatomy of older adults with MCI has not yet been clarified. This study aimed to investigate the effects of RT on cognition and brain anatomy in MCI. Forty-four older adults with MCI, 22 in the training group and 22 in the control group, were evaluated in neuropsychological tests and magnetic resonance imaging at the beginning and end of the study, which lasted 24 weeks. We used repeated measures ANOVA. The training group showed better performance in verbal episodic memory after intervention. The control group showed a decrease in gray matter volume in the hippocampus and precuneus, while the training group showed no reduction in the right hippocampus and precuneus. However, it showed a decrease in the volume of these regions on the left side and in the left superior frontal gyrus. In the analysis of white matter integrity, fractional anisotropy increased in the training group and decreased in the control group. Axial diffusivity decreased in the training group, while radial diffusivity increased in the control group, and mean diffusivity varied according to the tract evaluated. RT improves memory performance, positively influences white matter integrity parameters, and plays a protective role against atrophy of the hippocampus and precuneus in MCI.</p>","PeriodicalId":12730,"journal":{"name":"GeroScience","volume":"25 1","pages":""},"PeriodicalIF":5.6,"publicationDate":"2025-01-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142911768","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A brief report on biomarkers of cellular senescence associated with liver frailty and length of stay in liver transplantation","authors":"William C. Miller, Matthew J. Yousefzadeh, Jessica Fisher, Heidi Sarumi, Varvara Kirchner, Laura J. Niedernhofer, Timothy Pruett","doi":"10.1007/s11357-024-01482-9","DOIUrl":"https://doi.org/10.1007/s11357-024-01482-9","url":null,"abstract":"<p>The proportion of older individuals needing liver transplantation is growing, resulting in an increasingly frail patient population. Frailty constitutes a constellation of cognitive and physical symptoms associated with aging and increases the risk of morbidity and mortality. Senescence is a programmed cell fate in response to stress implicated in causing frailty, age-related diseases, and aging itself. This study explores the relationship between cellular senescence, physical frailty, and liver transplantation. Adults &gt; 18 years old who underwent ambulatory liver transplantation at our center between September 1, 2022, and November 30, 2022, were included. Frailty assessments were performed using the Liver Frailty Index™, and blood was collected prior to transplantation. Expression of <i>p16</i>^<i>INK4a</i> and <i>p21</i>^<i>CIP1</i> mRNA in T cells was measured by RT-qPCR, an established proxy for senescent cell burden, and plasma levels of senescence-associated secretory phenotype proteins were measured by multiplex ELISA. Patient outcomes were collected via electronic medical record. Univariate linear regression analysis demonstrated a statistically significant relationship between baseline patient frailty and <i>p16</i>^<i>INK4a</i> and <i>p21</i>^<i>CIP1</i> (<i>r</i>² = 0.5092, <i>p</i>-value = 0.0205; <i>r</i>² = 0.5339, <i>p</i>-value = 0.0164, respectively). A similar correlation occurred between <i>p16</i>^<i>INK4a</i> and <i>p21</i>^<i>CIP1</i> expression and length of hospitalization (<i>r</i>² = 0.4960, <i>p</i>-value = 0.0230; <i>r</i>² = 0.5868, <i>p</i>-value = 0.0098, respectively). This study revealed a potential association between biomarkers of cellular senescence, physical frailty, and length of hospitalization. This warrants further investigation as biomarkers to stratify patients are needed and therapeutics to reduce senescent cell burden exists and could be deployed to improve transplant outcomes.</p>","PeriodicalId":12730,"journal":{"name":"GeroScience","volume":"65 1","pages":""},"PeriodicalIF":5.6,"publicationDate":"2024-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142901810","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Detecting early stages of Alzheimer’s disease using a web-based cognitive battery","authors":"Jordan R. Hoffmeister, Brady R. Robison, Christopher T. Copeland, Calin I. Prodan, Jim G. Scott, Jordan M. Glenn","doi":"10.1007/s11357-024-01496-3","DOIUrl":"https://doi.org/10.1007/s11357-024-01496-3","url":null,"abstract":"<p>Portable and efficient cognitive screening measures are needed to address the growing need for effective early detection of Alzheimer’s disease. The Neurotrack Cognitive Battery (NCB) offers an appealing, web-based application that may be sensitive to early cognitive changes associated with Alzheimer’s disease. The NCB contains measures that were conceptually derived from animal lesion studies. The current study sought to investigate the construct and diagnostic validity of the NCB among those with and without mild cognitive impairment (MCI). Participants (<i>n</i> = 47) with and without MCI were administered the NCB and traditional cognitive tests. Three of six NCB measures assessing domains of memory, processing speed, and executive functioning demonstrated moderate to strong associations with well-established cognitive performance tests. In classifying those with and without MCI, sensitivities of these three NCB measures ranged from 0.47 to 0.74, and specificities ranged from 0.78 to 1.00. For traditional cognitive measures, sensitivities ranged from 0.74 to 0.84, and specificities ranged from 0.74 to 0.94. Overall, web-based cognitive test measures pertaining to cognitive domains of memory, processing speed, and executive functioning may serve as highly portable screening tools for detecting the early stages of Alzheimer’s disease. Additionally, these cognitive domains may be valuable in informing back-translational research.</p>","PeriodicalId":12730,"journal":{"name":"GeroScience","volume":"36 6 1","pages":""},"PeriodicalIF":5.6,"publicationDate":"2024-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142901765","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A machine learning approach identifies cellular senescence on transcriptome data of human cells in vitro","authors":"Shamsed Mahmud, Chen Zheng, Fernando E. Santiago, Lei Zhang, Paul D. Robbins, Xiao Dong","doi":"10.1007/s11357-024-01485-6","DOIUrl":"https://doi.org/10.1007/s11357-024-01485-6","url":null,"abstract":"<p>Although cellular senescence has been recognized as a hallmark of aging, it is challenging to detect senescence cells (SnCs) due to their high level of heterogeneity at the molecular level. Machine learning (ML) is likely an ideal approach to address this challenge because of its ability to recognize complex patterns that cannot be characterized by one or a few features, from high-dimensional data. To test this, we evaluated the performance of four ML algorithms including support vector machines (SVM), random forest (RF), decision tree (DT), and Soft Independent Modelling of Class Analogy (SIMCA), in distinguishing SnCs from controls based on bulk RNA sequencing data. The dataset includes 162 in vitro samples, covering three human cell types: fibroblasts, melanocytes, and keratinocytes, and three senescence inducers: irradiation, bleomycin treatment, and replication. Under tenfold and leave-one-out cross-validation, as well as independent dataset validation, all methods provided ~ 80% or higher accuracy, with SVM reaching over 99%. Similar accuracy was achieved using expert-curated gene lists, e.g., SenMayo and CellAge, instead of our algorithm-prioritized gene list using minimum redundancy-maximum relevance (mRMR). However, only a few genes overlapped between the gene sets, suggesting a wide impact of senescence on the transcriptome. Overall, our study demonstrated a proof-of-concept for identifying senescence using ML.</p>","PeriodicalId":12730,"journal":{"name":"GeroScience","volume":"14 1","pages":""},"PeriodicalIF":5.6,"publicationDate":"2024-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142901808","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Paroxetine promotes longevity via ser-7-dop-4-IIS axis in Caenorhabditis elegans","authors":"Yiming Zhou, Lijuan Chen, Meijing Wang, Yang Yang, Bin Hu, Guolin Li, Fang Wei","doi":"10.1007/s11357-024-01492-7","DOIUrl":"https://doi.org/10.1007/s11357-024-01492-7","url":null,"abstract":"<p>Paroxetine, a selective serotonin reuptake inhibitor, is widely used in the clinical treatment of depression. While several antidepressants show promise as geroprotectors, the role of paroxetine in aging remains unclear. In this study, we evaluated the lifespan extension effect of paroxetine in <i>Caenorhabditis elegans</i> (<i>C. elegans</i>) and elucidated the underlying mechanisms. The results showed that paroxetine can prolong lifespan concomitant extension of healthspan as indicated by increasing mobility and reducing lipofuscin accumulation, as well as confer protection to nematodes against different abiotic stresses. Paroxetine upregulated <i>ser-7</i> expression and downregulated <i>dop-4</i> expression. <i>dop-4</i> RNA interference (RNAi) mimicked the beneficial effect of paroxetine on lifespan. Conversely,<i> ser-7</i> RNAi abolished paroxetine-induced lifespan extension and the expression changes of <i>dop-4</i> and genes related to insulin/insulin-like growth factor 1 signaling (IIS). Moreover, paroxetine exhibited a comparable lifespan extension effect to that observed in <i>daf-2</i> or <i>age-1</i> mutants; however, this effect was abolished in <i>daf-16</i> mutant. Taken together, these results suggest that paroxetine promotes health and longevity in <i>C. elegans</i> through the <i>ser-7</i>-<i>dop-4</i>-IIS pathway, underscoring its potential as a geroprotector.</p>","PeriodicalId":12730,"journal":{"name":"GeroScience","volume":"310 1","pages":""},"PeriodicalIF":5.6,"publicationDate":"2024-12-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142888098","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}