GeroScience最新文献_第2页

Loss of microstructural integrity in left hemispheric white matter tracts is associated with poorer digits in noise understanding. 左半球白质束微结构完整性的丧失与手指对噪声的理解能力较差有关。

IF 5.6 2区医学

GeroScience Pub Date : 2025-05-26 DOI: 10.1007/s11357-025-01707-5

Jordi H C Boons,Gertjan Dingemanse,Elisabeth J Vinke,Bernd Kremer,Meike W Vernooij,André Goedegebure

{"title":"Loss of microstructural integrity in left hemispheric white matter tracts is associated with poorer digits in noise understanding.","authors":"Jordi H C Boons,Gertjan Dingemanse,Elisabeth J Vinke,Bernd Kremer,Meike W Vernooij,André Goedegebure","doi":"10.1007/s11357-025-01707-5","DOIUrl":"https://doi.org/10.1007/s11357-025-01707-5","url":null,"abstract":"Age-related hearing loss (ARHL) is a prevalent condition among older adults and is regarded as a potentially modifiable risk factor for dementia. Although multiple studies have investigated pure-tone thresholds as a measure for ARHL and its relationship to dementia, the potential role of the central auditory system has received little attention. To address this gap in the literature, this study investigates the relationship between central auditory functioning, assessed using the speech-reception-threshold (SRT) of the digits-in-noise (DIN) test, and the microstructural integrity of white matter tracts in the Rotterdam Study. A total of 1669 participants underwent the DIN test and had diffusion imaging data available. The SRT was found to be significantly associated with the microstructural integrity of the left inferior fronto-occipital fasciculus, inferior longitudinal fasciculus, and posterior thalamic radiation. After accounting for audibility effects, the association with the inferior fronto-occipital fasciculus and the inferior longitudinal fasciculus was even stronger, while the association with the posterior thalamic radiation was no longer significant. These findings suggest that age-related declines in specific brain regions may contribute to difficulties in speech-in-noise understanding among the elderly.","PeriodicalId":12730,"journal":{"name":"GeroScience","volume":"139 1","pages":""},"PeriodicalIF":5.6,"publicationDate":"2025-05-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144136659","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cognitive and neuroimaging outcome of very prodromal dementia with Lewy bodies. 极前驱痴呆伴路易体的认知和神经影像学结果。

IF 5.6 2区医学

GeroScience Pub Date : 2025-05-25 DOI: 10.1007/s11357-025-01701-x

Frédéric Blanc,Vincent Bouteloup,Claire Paquet,Marie Chupin,Florence Pasquier,Audrey Gabelle,Mathieu Ceccaldi,Paulo Loureiro de Sousa,Pierre Krolak-Salmon,Renaud David,Clara Fischer,Jean-François Dartigues,David Wallon,Olivier Moreaud,Mathilde Sauvée,Catherine Belin,Claire Roubaud,Anne Botzung,Alix Ravier,Catherine Demuynck,Izzie Namer,Marie-Odile Habert,Olivier Bousiges,Benoît Schorr,Candice Muller,Nathalie Philippi,Geneviève Chêne,Benjamin Cretin,Jean-François Mangin,Carole Dufouil

{"title":"Cognitive and neuroimaging outcome of very prodromal dementia with Lewy bodies.","authors":"Frédéric Blanc,Vincent Bouteloup,Claire Paquet,Marie Chupin,Florence Pasquier,Audrey Gabelle,Mathieu Ceccaldi,Paulo Loureiro de Sousa,Pierre Krolak-Salmon,Renaud David,Clara Fischer,Jean-François Dartigues,David Wallon,Olivier Moreaud,Mathilde Sauvée,Catherine Belin,Claire Roubaud,Anne Botzung,Alix Ravier,Catherine Demuynck,Izzie Namer,Marie-Odile Habert,Olivier Bousiges,Benoît Schorr,Candice Muller,Nathalie Philippi,Geneviève Chêne,Benjamin Cretin,Jean-François Mangin,Carole Dufouil","doi":"10.1007/s11357-025-01701-x","DOIUrl":"https://doi.org/10.1007/s11357-025-01701-x","url":null,"abstract":"The cognitive and neuroimaging evolution over the course of dementia with Lewy bodies (DLB) from prodromal stage - Pro-DLB (subjective (SCI) to mild cognitive impairment (MCI)) - is poorly understood. The aim of this study was to analyze from 5-year longitudinal data the trajectories of Pro-DLB patients. The \"Lewy- MEMENTO\" prospective clinical cohort recruited 773 patients for either SCI or MCI. The Pro-DLB group was compared to a group with prodromal Alzheimer's disease (Pro-AD), a group with \"prodromal DLB and AD\" (Pro-DLB + AD), and a group without prodromal DLB and AD (no symptom [NS]). We modeled the 5-year evolution of cognitive functions and the 2-year evolution of brain MRI volumetry on MRI and brain metabolism (FDG PET). The Pro-AD and Pro-DLB + AD groups had more cognitive and functional decline than the Pro-DLB and NS groups (P < .001). The Pro-DLB group had more cognitive decline than the NS group (P < .004). Incident dementia during the follow-up was higher in the Pro-AD (13.0 per 100 person-years) and Pro-DLB + AD (10.3) groups than in the Pro-DLB (1.02) and NS (0.44) groups (P < .001). The decline in the metabolism of the left orbitofrontal cortex was greater in the Pro-DLB + AD group. The volume decrease of hippocampi, entorhinal cortices, amygdalae, and left insula was higher in the Pro-AD and the pro-DLB + AD groups. Patients in the pro-DLB group had less cognitive, functional, brain volume, and metabolism decrease than patients in the Pro-AD and pro-DLB + AD groups. DLB would therefore be a less degenerative and more dysfunctional disease at the prodromal stage.","PeriodicalId":12730,"journal":{"name":"GeroScience","volume":"34 1","pages":""},"PeriodicalIF":5.6,"publicationDate":"2025-05-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144136710","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Sensory impairments and epigenetic aging: insights from self-rated hearing and vision in United States adults 感觉障碍和表观遗传衰老：来自美国成年人自评听力和视力的见解

IF 5.6 2区医学

GeroScience Pub Date : 2025-05-23 DOI: 10.1007/s11357-025-01706-6

Jamaji C. Nwanaji-Enwerem, Dennis Khodasevich, Nicole Gladish, Hanyang Shen, Anne K. Bozack, Saher Daredia, Belinda L. Needham, David H. Rehkopf, Andres Cardenas

{"title":"Sensory impairments and epigenetic aging: insights from self-rated hearing and vision in United States adults","authors":"Jamaji C. Nwanaji-Enwerem, Dennis Khodasevich, Nicole Gladish, Hanyang Shen, Anne K. Bozack, Saher Daredia, Belinda L. Needham, David H. Rehkopf, Andres Cardenas","doi":"10.1007/s11357-025-01706-6","DOIUrl":"https://doi.org/10.1007/s11357-025-01706-6","url":null,"abstract":"Sensory impairments are common with aging, but studies examining the relationships of these impairments with DNA methylation–based biomarkers of aging, strong predictors of morbidity and mortality, remain sparse. We investigated whether subjective measures of sensory impairment are associated with epigenetic age biomarkers. We conducted a cross-sectional analysis in a representative sample of 2344 U.S. adults from the 1999–2000 and 2001–2002 cycles of the National Health and Nutrition Examination Survey (NHANES). We examined the relationships of self-rated auditory and vision function with seven epigenetic aging biomarkers: HannumAge, HorvathAge, SkinBloodAge, PhenoAge, GrimAge2, DNA methylation telomere length, and DunedinPoAm. We adjusted for potential confounders including chronological age, other demographics, lifestyle factors, and general health. In adjusted survey-weighted models, self-reported deafness was associated with a significantly higher GrimAge2 (β = 4.19-years, 95% CI 2.29, 6.09, P = 0.004) and DunedinPoAm (β = 0.07, 95% CI 0.04, 0.09, P = 0.002) compared to good hearing. Deafness was also associated with significantly higher GrimAge2 estimates of TIMP1 (β = 459.51, 95% CI 287.00, 632.03 P = 0.002) and marginally higher estimated levels of ADM (β = 10.06, 95% CI 1.76, 18.36, P = 0.03), CRP (β = 0.34, 95% CI 0.11, 0.56, P = 0.01), and cigarette pack-years (β = 6.55, 95% CI 2.62, 10.47, P = 0.01). No associations were observed with self-rated vision. We describe associations of self-rated deafness with accelerated epigenetic aging, as measured by GrimAge2 and DunedinPoAm. These results provide a foundation for future research exploring epigenetic biomarkers as tools for predicting and understanding the biological processes underlying sensory impairments like deafness.","PeriodicalId":12730,"journal":{"name":"GeroScience","volume":"46 1","pages":""},"PeriodicalIF":5.6,"publicationDate":"2025-05-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144123019","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Amyloid neuropathy, tauopathy, decreased cholinergic and dopaminergic neurons, long-term memory and motor deficits, and sleep disturbance in motopsin deficient mice. 淀粉样神经病变、牛头病、胆碱能和多巴胺能神经元减少、长期记忆和运动缺陷以及睡眠障碍。

IF 5.6 2区医学

GeroScience Pub Date : 2025-05-23 DOI: 10.1007/s11357-025-01694-7

Fumiaki Yokoi,Yuuna Tanaka,Akari Sakai,Nao Isogai,Shiori Miyata,Shinichi Mitsui

{"title":"Amyloid neuropathy, tauopathy, decreased cholinergic and dopaminergic neurons, long-term memory and motor deficits, and sleep disturbance in motopsin deficient mice.","authors":"Fumiaki Yokoi,Yuuna Tanaka,Akari Sakai,Nao Isogai,Shiori Miyata,Shinichi Mitsui","doi":"10.1007/s11357-025-01694-7","DOIUrl":"https://doi.org/10.1007/s11357-025-01694-7","url":null,"abstract":"Truncating mutation in motopsin (neurotrypsin/PRSS12) gene causes an autosomal recessive non-syndromic intellectual disability. Since motopsin cleaves agrin, motopsin deficiency causes accumulation of long form agrin. Agrin binds amyloid β (Aβ) and accelerates Aβ fibril formation in Alzheimer's disease (AD). Down's syndrome (DS) exhibits AD-like neuropathological changes. Agrin also contributes to Parkinson's disease (PD). Degeneration of cholinergic neurons is relevant to AD, whereas degeneration of dopaminergic neurons causes PD and PD-associated cognitive impairment and dementia. Although there is a functional relationship between agrin and amyloidosis, it has not been clear whether motopsin deficiency induces amyloid neuropathy or not. Here, motopsin knock-out (KO) mice increased hippocampal amyloid and phosphorylated tau deposits. Agrin and amyloid oligomers were colocalized in the amyloid angiopathy. Motopsin KO mice also exhibited motor deficits. Motopsin KO male mice decreased cholinergic neurons in the vertical limb of the diagonal band of Broca and dopaminergic neurons in the substantia nigra compacta and the ventral tegmental area, and showed long-term memory deficits for object recognition, hypoactivity, and shorter sleeping time. Motopsin KO female mice decreased cholinergic neurons in the medial septum and showed hyperactivity. The results suggest that this intellectual disability is produced by a complex mechanism relating to AD, DS, PD, PD-associated cognitive impairment, and cerebrovascular dementia. The results also suggest that motopsin KO mouse can be a novel animal model for these diseases. Development of therapeutics, that reduce amyloid and phosphorylated tau deposits and protect cholinergic and dopaminergic neurons, will be useful to prevent the progress of this disease.","PeriodicalId":12730,"journal":{"name":"GeroScience","volume":"18 1","pages":""},"PeriodicalIF":5.6,"publicationDate":"2025-05-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144122262","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Impacts of systemic milieu on cerebrovascular and brain aging: insights from heterochronic parabiosis, blood exchange, and plasma transfer experiments. 系统环境对脑血管和脑衰老的影响：来自异慢性异种共生、血液交换和血浆移植实验的见解。

IF 5.6 2区医学

GeroScience Pub Date : 2025-05-23 DOI: 10.1007/s11357-025-01657-y

Rafal Gulej,Roland Patai,Anna Ungvari,Attila Kallai,Stefano Tarantini,Andriy Yabluchanskiy,Derek M Huffman,Michael J Conboy,Irina M Conboy,Mika Kivimäki,Anna Csiszar,Zoltan Ungvari

{"title":"Impacts of systemic milieu on cerebrovascular and brain aging: insights from heterochronic parabiosis, blood exchange, and plasma transfer experiments.","authors":"Rafal Gulej,Roland Patai,Anna Ungvari,Attila Kallai,Stefano Tarantini,Andriy Yabluchanskiy,Derek M Huffman,Michael J Conboy,Irina M Conboy,Mika Kivimäki,Anna Csiszar,Zoltan Ungvari","doi":"10.1007/s11357-025-01657-y","DOIUrl":"https://doi.org/10.1007/s11357-025-01657-y","url":null,"abstract":"Aging is a complex biological process that detrimentally affects the brain and cerebrovascular system, contributing to the pathogenesis of age-related diseases like vascular cognitive impairment and dementia (VCID) and Alzheimer's disease (AD). While cell-autonomous mechanisms that occur within cells, independent of external signals from neighboring cells or systemic factors, account for some aspects of aging, they cannot explain the entire aging process. Non-autonomous, paracrine and endocrine, pathways also play a crucial role in orchestrating brain and vascular aging. The systemic milieu modulates aging through pro-geronic and anti-geronic circulating factors that mediate age-related decline or confer rejuvenative effects. This review explores the impact of systemic factors on cerebrovascular and brain aging, with a particular focus on findings from heterochronic parabiosis, blood exchange, and plasma transfer experiments. We discuss how these factors influence fundamental cellular and molecular processes of aging and impact cerebrovascular endothelial function, neurovascular coupling mechanisms, blood-brain barrier integrity, neuroinflammation, capillary density, and amyloid pathologies, with significant consequences for cognitive function. Additionally, we address the translational potential and challenges of modifying the systemic milieu to promote brain health and prevent age-related cognitive impairment.","PeriodicalId":12730,"journal":{"name":"GeroScience","volume":"14 1","pages":""},"PeriodicalIF":5.6,"publicationDate":"2025-05-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144122225","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

How aging impacts cortical dynamics and gait during dual-task turning revealed by fNIRS fNIRS揭示的双任务转弯过程中，衰老如何影响皮质动力学和步态

IF 5.6 2区医学

GeroScience Pub Date : 2025-05-23 DOI: 10.1007/s11357-025-01687-6

Yuqi Dong, Chen Yang, Yan Chen, Feng Pan, Jinwei Wang, Cui Zhang

{"title":"How aging impacts cortical dynamics and gait during dual-task turning revealed by fNIRS","authors":"Yuqi Dong, Chen Yang, Yan Chen, Feng Pan, Jinwei Wang, Cui Zhang","doi":"10.1007/s11357-025-01687-6","DOIUrl":"https://doi.org/10.1007/s11357-025-01687-6","url":null,"abstract":"The aim of this study is to explore the differences in cortical activation and gait performance during turning walking under cognitive dual-task conditions between young and older adults during cognitive-turning dual task walking, as well as variations in brain functional connectivity in this context. Seventeen young adults and seventeen older adults were included in the study. All participants completed two tasks: a figure-eight turning walk (single-task, ST) and a figure-eight turning walking while performing a digital alert cognitive task (dual-task, DT). Data collection was conducted using functional near-infrared spectroscopy and a three-dimensional motion capture system to extract and calculate the activation of motor and sensory cortices, functional connectivity, and gait parameters. Compared to ST, the cortical activation in the young adults was significantly increased during DT (p ≤ 0.041) and was higher than that of the older adults (p ≤ 0.003); the older adults showed no significant change in cortical activation, and the stride length decreased (p = 0.013) and was lower than that of the young adults (p = 0.023). Additionally, compared to ST, the functional connectivity between primary somatosensory cortex and other brain regions increased in the older adults during DT (p ≤ 0.035). The older adults are more likely to fall when performing cognitive-turning DT. One of the important reasons for the difference between them and young adults is the distinct brain modulation mechanisms employed by the two groups when facing challenging dual tasks. Enhancing brain functional connectivity may be a more effective strategy for the older adults to promoting dual-task performance. This study provides insights for aging-related steering disorders and more evidence for the influence of aging on neuro-motor control mechanism.","PeriodicalId":12730,"journal":{"name":"GeroScience","volume":"16 1","pages":""},"PeriodicalIF":5.6,"publicationDate":"2025-05-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144130302","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A non-invasive approach to monitoring microcirculatory health before and after hemodialysis in renal patients using nailfold video capillaroscopy with optical reflectance analysis 甲襞视频毛细血管镜与光学反射分析在肾脏患者血液透析前后监测微循环健康的无创方法

IF 5.6 2区医学

GeroScience Pub Date : 2025-05-17 DOI: 10.1007/s11357-025-01700-y

Hiroki Suzuki, Hiroki Nagano, Keiji Kawagoe, Ichiro Miura, Kazuto Masamoto

{"title":"A non-invasive approach to monitoring microcirculatory health before and after hemodialysis in renal patients using nailfold video capillaroscopy with optical reflectance analysis","authors":"Hiroki Suzuki, Hiroki Nagano, Keiji Kawagoe, Ichiro Miura, Kazuto Masamoto","doi":"10.1007/s11357-025-01700-y","DOIUrl":"https://doi.org/10.1007/s11357-025-01700-y","url":null,"abstract":"Maintaining physiological blood pressure is a critical goal in the prevention of cardiovascular events, whereas tissue perfusion depends on the balance between systemic blood pressure and tissue microvascular resistance. The nailfold capillary is considered a window for directly assessing microvascular flow in the body. In this study, nailfold video capillaroscopy was used to determine the acute effects of hemodialysis on microvascular flow dynamics and optical reflectance in 11 patients with renal disease (ages 71 ± 14 years). The study aimed to determine if capillary morphology, flow dynamics, or optical reflectance are sensitive to hemodialysis-induced changes in blood composition. The capillary morphologies, flow speed distributions, and pixel intensity fluctuations before and after hemodialysis were compared via previously developed image analysis software. The correlations of the measured parameters with blood compositions were then examined. No consistent changes in measured capillary diameters, lengths, or flow speeds were observed with dialysis. In contrast, the temporal variations in optical reflectance were significantly altered after dialysis and were observed to be correlated with changes in inorganic phosphate concentrations. Finally, the capillary flow speed was found to be independent of the spatiotemporal variations in capillary diameter. In conclusion, dynamic changes in the optical reflectance represent acute changes in blood composition that are induced by hemodialysis. These findings underscore the potential of using non-invasive video capillaroscopy clinically to monitor microcirculatory health and manage cardiovascular risk in patients with renal disease.","PeriodicalId":12730,"journal":{"name":"GeroScience","volume":"122 1","pages":""},"PeriodicalIF":5.6,"publicationDate":"2025-05-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144067195","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cross-sectional associations of epigenetic clocks with intrinsic capacity and functional ability in older adults with frailty and cognitive impairment: the COGFRAIL study 表观遗传时钟与虚弱和认知障碍老年人内在能力和功能能力的横断面关联：cog虚弱研究

IF 5.6 2区医学

GeroScience Pub Date : 2025-05-16 DOI: 10.1007/s11357-025-01698-3

Pedro L. Valenzuela, Juan Luis Sánchez-Sánchez, Paul Bensadoun, Jean-Marc Lemaître, Bruno Vellas, Sandrine Sourdet, Philipe de Souto Barreto

{"title":"Cross-sectional associations of epigenetic clocks with intrinsic capacity and functional ability in older adults with frailty and cognitive impairment: the COGFRAIL study","authors":"Pedro L. Valenzuela, Juan Luis Sánchez-Sánchez, Paul Bensadoun, Jean-Marc Lemaître, Bruno Vellas, Sandrine Sourdet, Philipe de Souto Barreto","doi":"10.1007/s11357-025-01698-3","DOIUrl":"https://doi.org/10.1007/s11357-025-01698-3","url":null,"abstract":"Functional ability and intrinsic capacity (IC) have been proposed as determinants of healthy aging, but the extent to which these indicators are affected by biological aging remains unknown. We explored the association of biological age acceleration (BAA) with functional ability and IC in older adults with physical and cognitive impairments. This cross-sectional study used data from 163 individuals (84.0 ± 5.2 years [range 72–99], 61.8% women) of the COGFRAIL cohort. Functional ability on basic (BADL-Katz Index) and instrumental activities of daily living (IADL-Lawton Index) was assessed. IC was measured as a composite score (0–100, higher is better) including the locomotion, cognition, psychology, sensory, and vitality domains. BAA was assessed by Horvath’s, Hannum’s, PhenoAge, and GrimAge epigenetic clocks. In the fully adjusted model, higher BAAPhenoAGe was associated to lower functional ability in BADLs (β = − 0.021, 95% confidence interval = − 0.038 to − 0.003, p = 0.022), with no significant results observed for the remaining clocks. No significant association was found between BAA and IC, but some associations were found with specific IC domains. Particularly, BAAGrimAge was associated with lower locomotion scores (β = − 1.179, 2.286 to − 0.072, p = 0.037), while BAAPhenoAge tended to be associated with lower scores in vitality (β = − 0.257, − 0.539 to 0.025, p = 0.073). Higher BAAPhenoage was associated with lower functional ability in very old adults with frailty and cognitive impairment. Although no biological clock was associated with a composite IC score, some associations were found between second-generation epigenetic clocks and specific IC domains.","PeriodicalId":12730,"journal":{"name":"GeroScience","volume":"152 1","pages":""},"PeriodicalIF":5.6,"publicationDate":"2025-05-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144067196","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Association of APOC1 with cortical atrophy during conversion to Alzheimer’s disease apo1与阿尔茨海默病转化过程中皮质萎缩的关系

IF 5.6 2区医学

GeroScience Pub Date : 2025-05-15 DOI: 10.1007/s11357-025-01695-6

Sewook Oh, Sunghun Kim, Jun Pyo Kim, Sang Won Seo, Bo-yong Park, Hyunjin Park

{"title":"Association of APOC1 with cortical atrophy during conversion to Alzheimer’s disease","authors":"Sewook Oh, Sunghun Kim, Jun Pyo Kim, Sang Won Seo, Bo-yong Park, Hyunjin Park","doi":"10.1007/s11357-025-01695-6","DOIUrl":"https://doi.org/10.1007/s11357-025-01695-6","url":null,"abstract":"Alzheimer’s disease (AD) is a prevalent neurodegenerative disorder, with its progression influenced by aberrant gene expression and alterations in the brain network topology. Although APOE has been extensively studied in relation to AD, the role of APOC1 remains relatively underexplored. This study investigated the impact of APOC1 on changes in cortical thickness (CTh) during conversion to AD in a longitudinal setting. Using a normative modeling approach, we examined changes in CTh in patients with mild cognitive impairment (MCI). The spatial patterns of CTh changes were then correlated with APOC1 mRNA expression levels. We estimated the time to conversion to AD and compared progression rates between the low and high APOC1 expression groups. Finally, mediation analysis was performed to assess the indirect effects of APOC1 expression on memory function via CTh changes. In patients with MCI and AD, reduced CTh was observed in the limbic and default mode regions, with a notable impact on the entorhinal cortex, parahippocampus, and fusiform gyrus when comparing baseline and follow-up measurements. The degree of change in CTh was significantly associated with APOC1 expression, with the paralimbic regions identified as particularly vulnerable. Furthermore, the high APOC1 expression group demonstrated more rapid conversion to AD than that observed in the low expression group. Mediation analysis indicated a trend suggesting that APOC1 expression indirectly affected memory and cognitive function through its influence on CTh. These results highlight the potential of APOC1 as an additional focus of AD research, offering insights into the genetic influences on AD pathology.","PeriodicalId":12730,"journal":{"name":"GeroScience","volume":"73 1","pages":""},"PeriodicalIF":5.6,"publicationDate":"2025-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143979666","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Dietary patterns and mortality risk in geriatric patients with atherosclerotic cardiovascular disease: an analysis of the National Health and Nutrition Examination Survey. 老年动脉粥样硬化性心血管疾病患者的饮食模式和死亡风险：国家健康和营养检查调查的分析

IF 5.6 2区医学

GeroScience Pub Date : 2025-05-14 DOI: 10.1007/s11357-025-01690-x

Meiqi Wang,Xuerong Jia,Dongyue Chen,GaoJin Pei,Zhiruo Song,Mengna Peng,Kangmo Huang,Xinfeng Liu

{"title":"Dietary patterns and mortality risk in geriatric patients with atherosclerotic cardiovascular disease: an analysis of the National Health and Nutrition Examination Survey.","authors":"Meiqi Wang,Xuerong Jia,Dongyue Chen,GaoJin Pei,Zhiruo Song,Mengna Peng,Kangmo Huang,Xinfeng Liu","doi":"10.1007/s11357-025-01690-x","DOIUrl":"https://doi.org/10.1007/s11357-025-01690-x","url":null,"abstract":"Atherosclerotic cardiovascular disease (ASCVD) has a high incidence and a significant impact on quality of life, especially in older adults. Healthy diets potentially improve patient outcomes, but the most beneficial dietary pattern remains unclear. Therefore, we aimed to evaluate the effectiveness of different dietary patterns in improving outcomes for geriatric patients with ASCVD. This study used data from the National Health and Nutrition Examination Survey (NHANES) database (2003-2006) on older adults (≥ 60 years). Scores for the Healthy Eating Index 2015 (HEI-2015) diet, Mediterranean-style diet (MED), Dietary Approaches to Stop Hypertension (DASH), and Mediterranean-DASH intervention for neurodegenerative delay (MIND) diet were calculated. Cox proportional hazard models assessed the associations of different dietary patterns with all-cause and cardiovascular (CV) deaths in patients with ASCVD. The total population included 674 patients, including 453 (67.21%) all-cause deaths and 186 (27.60%) CV deaths, with a mean follow-up time of 117.5 months. Greater adherence to the MIND diet was associated with a lower risk of all-cause mortality (adjusted HR = 0.75, 95%CI:0.58, 0.96, P for trend = 0.016), whereas other dietary patterns had no significant associations (all P values > 0.05). No dietary pattern was significantly associated with CV mortality (all P values > 0.05). Moreover, the MIND diet significantly interacted with the inflammatory status in predicting all-cause mortality (P for interaction < 0.05). For older ASCVD patients, higher adherence to the MIND diet is associated with reduced all-cause mortality, with inflammation significantly modulating this effect. The MIND diet may be the most beneficial eating pattern for this population.","PeriodicalId":12730,"journal":{"name":"GeroScience","volume":"77 1","pages":""},"PeriodicalIF":5.6,"publicationDate":"2025-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143945290","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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