GeroScience最新文献

{"title":"Self-report and actigraphy measures of sleep and domain-specific cognitive performance in older adults","authors":"Kelsey R. Sewell, Audrey M. Collins, Miranda G. Chappel-Farley, Shivangi Jain, Haiqing Huang, George Grove, Arthur F. Kramer, Edward McAuley, Jeffrey Burns, Charles Hillman, Eric Vidoni, Anna Marsland, Chaeryon Kang, Lu Wan, Kristine A. Wilckens, Kirk I. Erickson","doi":"10.1007/s11357-025-01665-y","DOIUrl":"https://doi.org/10.1007/s11357-025-01665-y","url":null,"abstract":"<p>Poor sleep is associated with worse cognitive function in older adults. However, nuanced associations between sleep and cognition might be masked by the multidimensional nature of sleep which requires multiple approaches (e.g., self-report and actigraphy) to gain meaningful insight. We investigated associations of sleep with cognition and hypothesized that the most consistent association would be between self-reported sleep duration and actigraphy-measured wake after sleep onset (WASO). We utilized baseline data from the Investigating Gains in Neurocognition in an Intervention Trial of Exercise study. Cognitively unimpaired older adults (<i>n</i>=589, aged 65–80) completed a comprehensive cognitive assessment with generation of five domain-specific cognitive composite scores. Sleep was measured via the Pittsburgh Sleep Quality Index (PSQI) and 24-h actigraphy (GT9X Link). Greater actigraphy WASO and shorter self-reported sleep duration were associated with poorer performance in all five cognitive domains (<i>β</i>_{[range: WASO]} = −0.14 to −0.19, all <i>p</i>&lt;0.05; <i>β</i>_{[range: duration]} = 0.08–0.15, all <i>p</i>&lt;0.05). Shorter actigraphy sleep duration was also associated with poorer EF/attentional control (<i>β</i>=0.09, <i>p</i>=0.020) and processing speed (<i>β</i>=0.10, <i>p</i>=0.013). Actigraphy and self-reported sleep were more strongly associated with episodic memory in older (74 years) and younger (66 years) individuals, respectively. Actigraphy-derived WASO was consistently and robustly associated with cognitive performance. Additionally, our results suggest that self-reported sleep duration provides insight into sleep behaviors related to brain health (e.g., long periods of still wakefulness), beyond actigraphy-measured sleep duration. Thus, both self-report and actigraphy measures of sleep provide critical and unique information for interpreting relationships with cognitive performance.</p>","PeriodicalId":12730,"journal":{"name":"GeroScience","volume":"7 1","pages":""},"PeriodicalIF":5.6,"publicationDate":"2025-04-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143872999","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Longitudinal changes in blood-borne geroscience biomarkers: results from a population-based study","authors":"Anna Picca, Ngoc Viet Nguyen, Riccardo Calvani, Matilda Dale, Claudia Fredolini, Emanuele Marzetti, Amaia Calderón-Larrañaga, Davide Liborio Vetrano","doi":"10.1007/s11357-025-01666-x","DOIUrl":"https://doi.org/10.1007/s11357-025-01666-x","url":null,"abstract":"<p>Multi-marker approaches are well suited for untangling the intrinsic complexity of aging and related conditions. Herein, we quantified (1) baseline concentrations of a panel of geroscience biomarkers pertaining to four biological domains (i.e., metabolism, inflammation, vascular/organ dysfunction and cellular senescence, and neurodegeneration) in individuals aged ≥60 years; (2) investigated linear and non-linear changes in biomarker levels over a 6-year period according to age and sex; and (3) described the relationships among geroscience biomarkers at baseline and follow-up. We found that repeated measures of age-dependent changes of 47 blood-borne biomarkers over 6 years had differential associations depending on the biological domains. The most relevant biomolecules in the associations between age and repeated assessments were (1) adiponectin, C-peptide, renin (metabolism), (2) CXCL10, IL-1α, IL-1β, IL-6, IL-10, IL-12p70, MPO (inflammation), (3) cystatin C, MMP7, MMP12, VCAM-1 (vascular/organ dysfunction and cellular senescence), and (4) S100B and Tau protein (neurodegeneration). Among these molecules, a negative association with increasing age was found for IL-1α, IL-1β, IL-12p70, S100B, and Tau protein. Non-linear relationships were also identified with age for IGFBP-1, leptin, β2M, TNFRSF1B, fibrinogen, GDF-15, N-cadherin, and BDNF. Our results indicate that inflammatory and metabolic biomolecules are strongly associated with aging over 6 years of follow-up. Whether the biological pathways reflected by these biomarkers contribute to the aging process or are associated with negative health-related events needs to be explored through comprehensive multi-omics longitudinal analysis in larger cohorts.</p>","PeriodicalId":12730,"journal":{"name":"GeroScience","volume":"48 1","pages":""},"PeriodicalIF":5.6,"publicationDate":"2025-04-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143866102","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Normal cerebral oxygen consumption and lactate levels in patients with Alzheimer’s disease and Lewy body dementia","authors":"Christian Sandøe Musaeus, Gunhild Waldemar, Troels Wesenberg Kjær, Birgitte Bo Andersen, Peter Høgh, Steen Gregers Hasselbalch, Ulrich Lindberg, Kristian Steen Frederiksen, Henrik Bo Wiberg Larsson, Mark B. Vestergaard","doi":"10.1007/s11357-025-01658-x","DOIUrl":"https://doi.org/10.1007/s11357-025-01658-x","url":null,"abstract":"<p>Brain metabolism is reduced in patients with dementia disorders, as demonstrated by hypometabolism on 2-deoxy-2-[¹⁸F]fluoroglucose ([¹⁸F]FDG) positron emissions tomography. A contributing factor to the hypometabolism could be decreased cerebral blood flow (CBF) leading to a state of subtle hypoperfusion‐induced tissue hypoxia causing a reduced brain oxygen metabolism and consequently elevated brain lactate. In the current exploratory study, we investigated brain lactate, global and regional CBF, and global cerebral metabolic rate of oxygen (CMRO₂) in patients with Alzheimer’s disease (AD) and dementia with Lewy bodies (DLBs). We hypothesized that the patients demonstrate a state of tissue hypoxia with reduced CMRO₂ and elevated brain lactate concentration. Participants included 24 AD patients, 10 DLB patients, and 15 healthy controls. MR spectroscopy measured lactate in the precuneus and occipital lobe. Global CBF and venous oxygen saturation (for CMRO2 calculation) were assessed using phase-contrast and susceptibility-based oximetry MRI, respectively. Regional CBF was measured with ASL-MRI. We observed no significant difference in either brain lactate or CMRO₂ between groups. The regional CBF in precuneus was significantly lower in AD compared to HC; however, this hypoperfusion was not associated with a higher lactate concentration. The lack of a difference in CMRO₂ or lactate concentration between patients and controls suggests that the hypometabolism observed in patients with AD and DLB may reflect structural neurodegeneration and not a state of tissue hypoxia. The local decrease of CBF in precuneus in patients with AD may be due to a lower CBF demand due to neurodegeneration.</p>","PeriodicalId":12730,"journal":{"name":"GeroScience","volume":"69 1","pages":""},"PeriodicalIF":5.6,"publicationDate":"2025-04-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143866194","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"\"Doctored: fraud, arrogance, and tragedy in the quest to cure Alzheimer's\": an important new book with direct relevance to GeroScience.","authors":"Csaba Szabo","doi":"10.1007/s11357-025-01661-2","DOIUrl":"https://doi.org/10.1007/s11357-025-01661-2","url":null,"abstract":"","PeriodicalId":12730,"journal":{"name":"GeroScience","volume":"13 1","pages":""},"PeriodicalIF":5.6,"publicationDate":"2025-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143866103","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction to: Whole‑body networks: a holistic approach for studying aging","authors":"Orestis Stylianou, Johannes M. Meixner, Tilman Schlick, Colin M. Krüger","doi":"10.1007/s11357-025-01616-7","DOIUrl":"https://doi.org/10.1007/s11357-025-01616-7","url":null,"abstract":"","PeriodicalId":12730,"journal":{"name":"GeroScience","volume":"29 1","pages":""},"PeriodicalIF":5.6,"publicationDate":"2025-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143857834","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sex differences in body mass index and waist circumference trajectories and dementia risk: the HUNT4 70+ study","authors":"Ekaterina Zotcheva, Bjørn Heine Strand, Vegard Skirbekk, Kay Deckers, Steinar Krokstad, Gill Livingston, Archana Singh-Manoux, Geir Selbæk","doi":"10.1007/s11357-025-01660-3","DOIUrl":"https://doi.org/10.1007/s11357-025-01660-3","url":null,"abstract":"<p>We examined associations between body mass index (BMI), waist circumference (WC), and dementia risk, and differences in BMI and WC trajectories before dementia diagnosis. We included 9,739 participants (54% women) aged 70+ from the Trøndelag Health Study (HUNT4 70+). BMI was measured four times (1984–2019) and WC three times (1995–2019). Dementia diagnoses were clinically assessed at HUNT4 70+ . Women and men with dementia had higher midlife BMI and WC than those without dementia. These differences diminished closer to diagnosis, especially in women. Midlife obesity in both sexes and midlife overweight, high WC, and overweight/obesity with high WC in men were linked to higher dementia risk. Lower dementia risk was observed with late-life overweight for both sexes, late-life high WC in women, late-life overweight/obesity with normal WC in men or high WC in women. Adiposity measures and their changes influence dementia risk differently in women and men.</p>","PeriodicalId":12730,"journal":{"name":"GeroScience","volume":"23 1","pages":""},"PeriodicalIF":5.6,"publicationDate":"2025-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143857833","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Alcohol and the aging cardiovascular system: a dangerous synergy uncovered.","authors":"Csaba Szabo","doi":"10.1007/s11357-025-01644-3","DOIUrl":"https://doi.org/10.1007/s11357-025-01644-3","url":null,"abstract":"","PeriodicalId":12730,"journal":{"name":"GeroScience","volume":"27 1","pages":""},"PeriodicalIF":5.6,"publicationDate":"2025-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143866182","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of aerobic exercise of different intensities on the social, emotional, and financial functioning of healthy older adults: results from a 16-week exercise randomized control trial","authors":"Charleen J. Gust, Renée Martin-Willett, Laurel P. Gibson, Gregory Giordano, Douglas R. Seals, Angela D. Bryan","doi":"10.1007/s11357-025-01655-0","DOIUrl":"https://doi.org/10.1007/s11357-025-01655-0","url":null,"abstract":"<p>Better social, emotional, and financial functioning are associated with improved health outcomes in older adults. While the literature supports a positive relationship between physical activity and increased functional ability in older adulthood, the intensity of physical activity necessary to achieve these gains remains uncertain. To address this gap, the current analysis uses data collected as part of a larger randomized controlled trial to examine the effects of a supervised exercise intervention on measures of social, emotional, and financial functioning. Healthy older adults (<i>n</i> = 211) completed baseline assessments including cardiovascular fitness and health and functioning measures and were randomly assigned to 16 weeks of either: (1) low intensity continuous training (LICT); or (2) moderate intensity continuous training + interval training (MICT + IT). Participants across exercise conditions reported a significant decrease from baseline to post-intervention in depression [<i>F</i>(1, 158) = 22.17, <i>p</i> &lt; .001] and instrumental risk taking [<i>F</i>(1, 157) = 6.72, <i>p</i> &lt; .05]. Further, participants assigned to the MICT + IT condition showed significantly greater improvements in loneliness relative to those in the LICT condition [<i>F</i>(1, 157) = 5.99, <i>p</i> &lt; .05]. By and large, healthy older adults experienced some improvements in functional ability after 16 weeks of exercise. Though most changes were not related to the intensity of exercise condition, associations between increased cardiovascular fitness and both depression and anxiety suggest that exercising at an intensity that improves fitness may confer greater benefits in some domains.</p><p>Trial registration: ClinicalTrials.gov, NCT02068612.</p>","PeriodicalId":12730,"journal":{"name":"GeroScience","volume":"18 1","pages":""},"PeriodicalIF":5.6,"publicationDate":"2025-04-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143857832","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of life-long hyperlipidaemia on age-dependent development of endothelial dysfunction in humanised dyslipidaemic mice","authors":"Anna Bar, Piotr Berkowicz, Anna Kurpinska, Tasnim Mohaissen, Agnieszka Karaś, Patrycja Kaczara, Joanna Suraj-Prażmowska, Magdalena Sternak, Brygida Marczyk, Agata Malinowska, Agnieszka Kij, Agnieszka Jasztal, Izabela Czyzynska-Cichon, Elsbet J. Pieterman, Hans M. G. Princen, Jacek R. Wiśniewski, Stefan Chlopicki","doi":"10.1007/s11357-025-01578-w","DOIUrl":"https://doi.org/10.1007/s11357-025-01578-w","url":null,"abstract":"<p>Little is known, how life-long hyperlipidaemia affects vascular ageing, before atherosclerosis. Here, we characterise effects of mild, life-long hyperlipidaemia on age-dependent endothelial dysfunction (ED) in humanised dyslipidaemia model of E3L.CETP mice. Vascular function was characterised using magnetic resonance imaging in vivo and wire myograph ex vivo. Plasma endothelial biomarkers and non-targeted proteomics in plasma and aorta were analysed. Early atherosclerosis lesions were occasionally present only in 40-week-old or older E3L.CETP mice. However, age-dependent ED developed earlier, in 14-week-old male and 22-week-old female E3L.CETP mice as compared with 40-week-old female and male C57BL/6J mice. Acetylcholine-induced vasodilation in 8-week-old E3L.CETP, especially female mice, was blocked by catalase and attributed to H₂O₂. In 8-week-old female E3L.CETP mice, changes in plasma proteome in response to hyperlipidaemia were modest, while in male mice a number of differentially expressed proteins were identified that were involved in oxidative stress response, inflammation and regulation of metabolic pathways. In contrast, in older E3L.CETP and C57BL/6J mice, either plasma or aortic proteome displayed similar pattern of vascular ageing, dominating over hyperlipidaemia-induced changes. Interestingly, in 48-week-old male but not female E3L.CETP mice, vascular mitochondrial functional response was impaired. Early resilience of hyperlipidaemia-induced detrimental effects in young female E3L.CETP mice on a functional level was associated with a switch in vasodilation mechanism, blunted systemic proteomic response in plasma and slower ED development as compared to male E3L.CETP mice. The results indicate that profile of early vascular response to risk factors in young age may determine level of ED in older age before atherosclerosis development.</p>","PeriodicalId":12730,"journal":{"name":"GeroScience","volume":"59 1","pages":""},"PeriodicalIF":5.6,"publicationDate":"2025-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143841305","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Glycation metabolites predict incident age-related comorbidities and mortality in older people with HIV","authors":"Xi Qiao, Liangliang Zhang, Emely A. Hoffman, Grace E. Mastin, Corrilynn O. Hileman, Asha R. Kallianpur, Ming Wang, Ronald J. Ellis, Susan L. Koletar, Frank J. Palella, Katherine K. Tassiopoulos, Alan L. Landay, Pankaj Kapahi, James J. Galligan, Robert C. Kalayjian","doi":"10.1007/s11357-025-01652-3","DOIUrl":"https://doi.org/10.1007/s11357-025-01652-3","url":null,"abstract":"<p>Glycation is a class of modifications arising from non-enzymatic reactions of reducing sugars with proteins, lipids, and/or DNA, generating advanced glycation end-products (AGEs). AGEs are linked to many age-related comorbidities. In response to HIV-1 infection, activated T-cells and macrophages shift their predominate metabolism from oxidative phosphorylation to glycolysis. Increased glycolytic flux enhances AGE formation, which may increase age-related comorbidities. In this prospective, multicenter cohort study of antiretroviral therapy treated people with HIV, we explored predictive associations by baseline plasma AGE concentrations and their corresponding detoxification metabolites, with incident comorbidities and mortality. AGEs included dicarbonyl sugars: 3-deoxyglucosone, glyoxal, and methylglyoxal. Methylglyoxal-derived metabolites included carboxyethyl-arginine, carboxyethyl-lysine, and methylglyoxal hydroimidazolone-1. Detoxification metabolites included reduced and oxidized glutathione, and the glyoxalase cycle products lactoyl-glutathione and lactoyl-Lysine modified proteins. Plasma was collected at study entry, in the fasting state, and assayed by liquid chromatography-mass spectroscopy. Incident clinical outcomes included diabetes, chronic kidney disease, hypertension, neurocognitive impairment, peripheral neuropathy, frailty, fractures, recurrent falls, and all-cause mortality. Among 376 participants, higher baseline plasma concentrations of methylglyoxal derived AGEs predicted increased risks of diabetes, chronic kidney disease, and recurrent falls, while higher 3-deoxyglucosone predicted an increased risk of peripheral neuropathy. By contrast, higher baseline concentrations of reduced or oxidized glutathione, lactoyl-glutathione, and/or lactoyl-Lysine modified proteins predicted lower risks of diabetes, neurocognitive impairment, frailty, fractures, recurrent falls, and all-cause mortality. These findings support growing experimental evidence of the potential to mitigate age-related declines by interventions that reduce glycation or increase glutathione.</p>","PeriodicalId":12730,"journal":{"name":"GeroScience","volume":"6 1","pages":""},"PeriodicalIF":5.6,"publicationDate":"2025-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143841357","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}