GeroScience最新文献

{"title":"Growth hormone–deficient Ames dwarf mice resist sarcopenia and exhibit enhanced endurance running performance at 24 months","authors":"Matthew J. Johnston, Sharlene G. Rakoczy, LaDora V. Thompson, Holly M. Brown-Borg","doi":"10.1007/s11357-025-01630-9","DOIUrl":"https://doi.org/10.1007/s11357-025-01630-9","url":null,"abstract":"<p>Ames dwarf mice (<i>df/df</i>) live 50% longer than normal littermates due to a genetic defect in growth hormone (GH) signaling. The enhanced longevity of Ames dwarfs has been studied extensively in an endocrinological context of cellular metabolism and increased resistance to oxidative stress (Bartke. World J Mens Health 37(1):19, 8; Bartke 2; BartkeJ Am Aging Assoc 23(4):219, 10; Bartke. World J Mens Health 39(3):454-465, 11; Brown-Borg et al. Nature 384(6604):33-33, 1; Masternak et al. 2018). However, the skeletal muscle system is relatively unexplored, the quality of which dictates metabolic homeostasis, permits movement and exercise, and exerts paracrine effects on other organs (Delmonico and Beck Am J Lifestyle Med 11(2):167-181, 25; Evans et al. GeroScience 46(1):183, 26; Kim and Kim. Endocrinol Metab (Seoul) 35(1):1-6, 15; Masternak et al. 2018). Here, we characterize the fitness capacity and skeletal muscle morphology of Ames mice to determine if previously established longevous effects of GH deficiency extend to skeletal muscle tissue. Mutually exclusive, age-matched cohorts of male Ames mice and wildtype controls performed grip strength, rotarod, and endurance running experiments over 6 months. The largest difference in physical performance was observed in endurance running capacity, where dwarf mice outperformed wildtype controls increasingly with age. Tibialis anterior (TA) muscles were evaluated for myofiber size, quality, and environment. Ames mice show reduced myofiber cross-sectional area (CSA) paired with increased myofibers per muscle. Dwarf myofiber populations are less heterogenous in size and seemingly resist sarcopenia, as skeletal muscle from aged individuals shows youthful morphological resemblance in mean myofiber CSA, size frequency distribution, and presence of fibrotic tissue. Declines in fitness performance and myofiber integrity were observable in age-matched wildtype controls. Utilizing an established longevity model to investigate skeletal muscle function and morphology is a novel approach to gaining insight into the seemingly inverse relationship between GH signaling and mammalian longevity.</p>","PeriodicalId":12730,"journal":{"name":"GeroScience","volume":"212 1","pages":""},"PeriodicalIF":5.6,"publicationDate":"2025-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143712733","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Paying attention to proprioception: age affects ankle proprioception and the attentional demand of proprioceptive processing in sedentary adults","authors":"Marie Julie Vermette, Emmeline Paré, François Prince, Julie Messier","doi":"10.1007/s11357-025-01609-6","DOIUrl":"https://doi.org/10.1007/s11357-025-01609-6","url":null,"abstract":"<p>Ankle proprioception and attentional resources are crucial for maintaining balance and safely driving. However, research exploring the age-related integrity of ankle proprioception has yielded conflicting results, while the attentional demand of proprioceptive processing in seniors remains underexplored. We investigated how aging affects the interaction between proprioception and attention in healthy sedentary adults using a novel dual-task paradigm. Sedentary old and young adults performed an ipsilateral proprioceptive-matching task with a long target encoding time and a cognitive-attentional subtraction task. These tasks were performed alone (single-task) or simultaneously (dual-task). Older adults showed significantly lower ankle proprioceptive accuracy and consistency in dorsiflexion compared to young adults under the single-task condition. Hence, the matching inaccuracies of seniors were more pronounced relative to young adults, when performing the proprioceptive and cognitive-attentional tasks simultaneously. Importantly, both age groups demonstrated similar cognitive performance in the single-task. However, while younger adults maintained their performance during dual-tasking, seniors showed markedly lower cognitive-attentional scores in the dual compared to the single-task condition. Thus, their dual-task costs were higher than those of young adults. Our findings of impaired ankle proprioception in sedentary older adults in the single-task underline the importance of controlling participants’ physical lifestyles and demonstrate that this novel paradigm is highly sensitive to age-related proprioceptive changes. Furthermore, the substantial decline in both proprioceptive and cognitive performance during dual-tasking suggests that sedentary older adults mobilize increasingly large cognitive-attentional resources to process proprioception. This dual-task paradigm may serve as a useful biomarker to predict falls and driving accidents in older populations.</p>","PeriodicalId":12730,"journal":{"name":"GeroScience","volume":"183 1","pages":""},"PeriodicalIF":5.6,"publicationDate":"2025-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143703175","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"WormRACER: Robust Analysis by Computer-Enhanced Recording","authors":"Bennett T. Van Camp, Quinn N. Zapata, Sean P. Curran","doi":"10.1007/s11357-025-01631-8","DOIUrl":"https://doi.org/10.1007/s11357-025-01631-8","url":null,"abstract":"<p>The pace of scientific high-throughput screening for age-related phenotypes requires the need for developing streamlined and efficacious methods of measuring and quantifying physiological outcomes and at a scale that enables adequate statistical power to measure the variation in populations. Here, we introduce Worm Robust Analysis by Computer-Enhanced Recording (WormRACER), a computationally efficient computer vision software capable of extracting six different crawling and swimming metrics from many animals simultaneously, including worm area, worm length, crawling speed, swimming speed, dynamic amplitude, and wave initiation rate (thrashing). Additionally, we developed a web-based portal that provides metric averages and metric vs time graphs that allow for simple data analysis and quality assurance. WormRACER will facilitate the rapid and quantitative characterization of movement as a facile measurement of healthspan enabling power for high-throughput screening of genetic, environmental, and pharmacological interventions.</p>","PeriodicalId":12730,"journal":{"name":"GeroScience","volume":"35 1","pages":""},"PeriodicalIF":5.6,"publicationDate":"2025-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143712734","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dietary mixed-oxysterols and 27-Hydroxycholesterol induce cognitive impairment by regulating gut microbiota and miR-144-3p in vivo","authors":"Tao Wang, Mengwei Ju, Xiaona Zhang, Wenjing Feng, Lijing Wang, Ling Hao, Huiyan Yu, Rong Xiao","doi":"10.1007/s11357-025-01628-3","DOIUrl":"https://doi.org/10.1007/s11357-025-01628-3","url":null,"abstract":"<p>Gut microbiota and microRNAs (miRNAs) have been proved to be intimately involved in dementia. Our previous studies have showed that oxysterols and the subsequent neurotoxic effects contributed to the pathogenesis of cognitive decline. However, the exact mechanism linking dietary oxysterol-induced cognitive changes, gut microbiota, and miRNAs remains elusive. Here, two sets of experiments were conducted on male C57BL/6J mice treated with mixed-oxysterol diet or 27-hydroxycholesterol (27-OHC) combined with antibiotic cocktails and miRNA antagonists. Neurobehavioral tests were conducted to assess learning and memory of mice. 16S ribosomal DNA gene sequencing was performed to evaluate microbial diversity and community composition. Oxysterol levels were detected using HPLC–MS. Western blotting and RT-qPCR were used to detect the expression of the intestinal barrier-related factors. We found that a 0.05% mixed-oxysterol diet altered the gut microbiota, damaged the intestinal barrier, upregulated the expression of miR-144-3p, and resulted in learning and memory impairment, while depleting the gut microbiota with antibiotic cocktails partly alleviated these injuries. Moreover, there were enhanced Aβ deposition, as well as higher 27-OHC and its metabolite in the brain of oxysterols-treated mice, which could be reduced by sterol 27-hydroxylase inhibitor-anastrozole, indicating that 27-OHC might be the key regulator of oxysterol-induced brain pathological changes. Additionally, by antagonizing miR-144-3p, microbiota dysbiosis-related Aβ deposition, oxysterol load, and cognitive decline were significantly ameliorated. Taken together, our study demonstrates that dietary oxysterols impair cognitive function through 27-OHC causing microbiota dysbiosis and intestinal barrier dysfunction, targeting miR-144-3p might be a promising strategy against cognitive impairment.</p><h3 data-test=\"abstract-sub-heading\">Graphical Abstract</h3>\u0000","PeriodicalId":12730,"journal":{"name":"GeroScience","volume":"47 1","pages":""},"PeriodicalIF":5.6,"publicationDate":"2025-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143703173","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Innovative approaches in the treatment-resistant depression: exploring different therapeutic pathways","authors":"Anna Łysik, Katarzyna Logoń, Aleksandra Szczygieł, Julia Wołoszczak, Martyna Wrześniewska, Jerzy Leszek","doi":"10.1007/s11357-025-01615-8","DOIUrl":"https://doi.org/10.1007/s11357-025-01615-8","url":null,"abstract":"<p>Treatment-resistant depression (TRD) remains a vital challenge in psychiatry, affecting a significant number of patients with major depressive disorder. Current pharmacological approaches often do not provide sufficient therapeutic results, prompting the need for innovative treatments. This review summarizes recent advances in TRD management, including non-pharmacological therapies such as transcranial magnetic stimulation, deep brain stimulation, electroconvulsive therapy, and vagus nerve stimulation, and describes their mechanisms of action. Novel pharmacotherapies, particularly glutamatergic modulators like ketamine and esketamine, have shown promising results with esketamine being available to eligible patients in Poland since 2023 within a drug program. Electroconvulsive therapy remains an effective treatment for TRD, usually with small side effects mainly including transient memory impairment, headache, or cardiovascular changes. Transcranial magnetic stimulation is a non-invasive procedure with proven efficacy; therefore several psychiatric organizations recommend it as a treatment option for major depressive disorder in their clinical guidelines. Deep brain stimulation is a relatively new treatment modality for TRD, with its primary risk being associated with the required neurosurgical procedure. Vagus nerve stimulation seems to be a promising adjunctive treatment for TRD, showing significant improvements in depressive symptoms, especially at higher electrical doses but with no side effects. While these treatments appear to have potential, personalized approaches are crucial for optimizing outcomes. Future research should focus on refining the techniques, improving safety profiles, and validating the long-term efficacy.</p>","PeriodicalId":12730,"journal":{"name":"GeroScience","volume":"7 1","pages":""},"PeriodicalIF":5.6,"publicationDate":"2025-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143695099","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prognostic impact of a senescence gene signature in multiple myeloma","authors":"Andrea Lehoczki, Otilia Menyhart, Hajnalka Andrikovics, Monika Fekete, Csaba Kiss, Gabor Mikala, Zoltan Ungvari, Balázs Győrffy","doi":"10.1007/s11357-025-01622-9","DOIUrl":"https://doi.org/10.1007/s11357-025-01622-9","url":null,"abstract":"<p>Multiple myeloma (MM), an incurable malignancy of plasma cells, is predominantly an age-related disease, with the majority of cases occurring in patients over the age of 60. Cellular senescence, a fundamental biological process underlying aging, has been increasingly recognized for its critical role in developing age-related malignancies. In this study, we aimed to investigate the prognostic significance of genes implicated in the molecular mechanisms of senescence within a large cohort of MM patients. Gene expression and clinical data from 1416 MM patients were obtained from four GEO datasets (GSE24080, GSE4204, GSE57317, and GSE9782) and integrated into a unified database. The raw data were processed using MAS5 normalization, scaling adjustments, and JetSet probe selection to ensure cross-platform comparability. A curated set of senescence-associated genes, the SenMayo gene signature, was employed for subsequent analyses. The final gene signature was computed as a weighted mean expression of 122 senescence-associated genes, with weights derived from univariate hazard ratios. Prognostic significance was evaluated using Cox regression, Kaplan–Meier survival analysis, and multivariate models incorporating clinical parameters such as gender, isotype, and molecular subtypes. False discovery rate (FDR) correction was applied to ensure the statistical robustness of findings. The weighted SenMayo gene signature strongly correlated with overall survival in MM patients (HR = 0.6, 95% CI = 0.47–0.76, <i>p</i> = 1.7e-05). The 75th percent probability of survival was reached at 36.1 months in the low-expression patient group, compared to 57 months in the high-expression group. Independent validation in datasets with sufficient patient numbers confirmed the prognostic value of the SenMayo signature (GSE4204: HR = 0.58, 95% CI = 0.39–0.88, <i>p</i> = 0.0089; GSE24080: HR = 0.61, 95% CI = 0.45–0.83, <i>p</i> = 0.0012; GSE57317: HR = 0.25, 95% CI = 0.08–0.77, <i>p</i> = 0.0095). Multivariate analyses further established the SenMayo signature as an independent prognostic factor, even when accounting for established clinical parameters such as sex and isotype. These findings underscore the robustness and independence of the SenMayo gene signature as a predictor of overall survival in multiple myeloma. This signature provides clinically valuable insights into the role of cellular senescence in disease progression.</p>","PeriodicalId":12730,"journal":{"name":"GeroScience","volume":"28 1","pages":""},"PeriodicalIF":5.6,"publicationDate":"2025-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143703049","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Functional ultrasound imaging reveals microvascular rarefaction, decreased cerebral blood flow, and impaired neurovascular coupling in a mouse model of paclitaxel-induced chemobrain","authors":"Siva Sai Chandragiri, Adam Nyul-Toth, Sharon Negri, Roland Patai, Rafal Gulej, Boglarka Csik, Santny Shanmugarama, Kiana Vali Kordestan, Mark Nagykaldi, Peter Mukli, Anna Ungvari, Andriy Yabluchanskiy, Zoltan Ungvari, Stefano Tarantini, Anna Csiszar","doi":"10.1007/s11357-025-01624-7","DOIUrl":"https://doi.org/10.1007/s11357-025-01624-7","url":null,"abstract":"<p>Chemotherapy-induced cognitive impairment (CICI), often referred to as “chemobrain,” significantly affects the quality of life in cancer survivors. Although traditionally attributed to neuronal toxicity, emerging evidence suggests a key role of cerebrovascular dysfunction in its pathogenesis. We hypothesized that paclitaxel (PTX, Taxol) treatment induces long-term cerebrovascular dysfunction, including microvascular rarefaction, impaired neurovascular coupling (NVC), and altered cerebral blood flow (CBF), which contribute to CICI. Using a clinically relevant PTX treatment regimen in non-tumor-bearing mice, we evaluated the long-term effects of PTX on cerebrovascular health. Ultrasound localization microscopy (ULM) and functional ultrasound imaging (fUS) were employed to assess microvascular density, CBF, and NVC. PTX treatment resulted in a significant reduction in microvascular density in the cerebral cortex and hippocampus, key regions involved in cognitive function. PTX significantly reduced blood velocity in the middle cerebral artery. Moreover, PTX impaired NVC responses, as evidenced by a diminished CBF increase in response to whisker stimulation, indicative of impaired reactive hyperemia. In conclusion, these findings demonstrate that PTX induces long-lasting cerebrovascular dysfunction, including microvascular rarefaction, impaired NVC, and altered CBF dynamics, which likely contribute to CICI. This study underscores the critical role of cerebrovascular health in cognitive function and highlights the potential of targeting cerebrovascular pathways as a therapeutic approach for mitigating chemotherapy-induced cognitive deficits.</p>","PeriodicalId":12730,"journal":{"name":"GeroScience","volume":"16 1","pages":""},"PeriodicalIF":5.6,"publicationDate":"2025-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143695098","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction to: White matter lipid alterations during aging in the rhesus monkey brain","authors":"Christina Dimovasili, Ana T. Vitantonio, Bryce Conner, Kelli L. Vaughan, Julie A. Mattison, Douglas L. Rosene","doi":"10.1007/s11357-025-01620-x","DOIUrl":"https://doi.org/10.1007/s11357-025-01620-x","url":null,"abstract":"","PeriodicalId":12730,"journal":{"name":"GeroScience","volume":"24 1","pages":""},"PeriodicalIF":5.6,"publicationDate":"2025-03-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143677705","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cortical adaptations in regional activity and backbone network following short-term postural training with visual feedback for older adults","authors":"Yi-Ching Chen, Yi-Ying Tsai, Wei-Min Huang, Chen-Guang Zhao, Ing-Shiou Hwang","doi":"10.1007/s11357-025-01614-9","DOIUrl":"https://doi.org/10.1007/s11357-025-01614-9","url":null,"abstract":"<p>This study investigated cortical reorganization in older adults following short-term interactive balance training. Twenty participants aged 65–74 received training in stabilometer stance, visually aligning plate movement with a horizontal line on a monitor. Pre-test and post-test measured posture fluctuations and scalp EEG during stabilometer stance. Results showed a training-related decrease in root mean square (RMS) (<i>p</i> = 0.001) and an increase in mean frequency (<i>p</i> = 0.006) of posture fluctuations. Despite a decline in theta relative power in Fp1 (<i>p</i> = 0.027), stabilometer training led to a post-test increase in alpha relative power around electrodes of the ventral visual pathway (<i>p</i> = 0.002). Additionally, augmentations were noted in theta relative power in Tp8 (<i>p</i> = 0.033) and beta relative power in F7 (<i>p</i> = 0.039). Analysis of the minimum spanning tree (MST) of alpha inter-regional connectivity indicated a training-related decrease in leaf fraction (<i>p</i> = 0.011) and increase in average eccentricity (<i>p</i> = 0.041), respectively. Training-related changes in the RMS of posture fluctuation were positively correlated with changes in pooled alpha relative power in electrodes of the ventral visual pathway (<i>r</i> = 0.459, <i>p</i> = 0.042) and negatively correlated with changes in average eccentricity of the alpha MST network (<i>r</i> = − 0.487, <i>p</i> = 0.029). In conclusion, short-term interactive training enhances balance by reorganizing regional and alpha-band network activities, which supports improved visual attention and prevents early visual processing idling during initial postural learning.</p>","PeriodicalId":12730,"journal":{"name":"GeroScience","volume":"123 1","pages":""},"PeriodicalIF":5.6,"publicationDate":"2025-03-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143677703","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cerebromicrovascular senescence in vascular cognitive impairment: does accelerated microvascular aging accompany atherosclerosis?","authors":"Anna Ungvari, Ádám Nyúl-Tóth, Roland Patai, Boglarka Csik, Rafal Gulej, Dorina Nagy, Santny Shanmugarama, Zoltán Benyó, Tamas Kiss, Zoltan Ungvari, Anna Csiszar","doi":"10.1007/s11357-025-01621-w","DOIUrl":"https://doi.org/10.1007/s11357-025-01621-w","url":null,"abstract":"<p>Vascular cognitive impairment (VCI) is a leading cause of age-related cognitive decline, driven by cerebrovascular dysfunction and cerebral small vessel disease (CSVD). Emerging evidence suggests that cerebromicrovascular endothelial senescence plays an important role in the pathogenesis of VCI by promoting cerebral blood flow dysregulation, neurovascular uncoupling, blood–brain barrier (BBB) disruption, and the development of cerebral microhemorrhages (CMHs). This review explores the concept of cerebromicrovascular senescence as a continuum of vascular aging, linking macrovascular atherosclerosis with microvascular dysfunction. It examines the mechanisms by which endothelial senescence drives neurovascular pathology and highlights the impact of cardiovascular risk factors in accelerating these processes. We examine preclinical and clinical studies that provide compelling evidence that atherosclerosis-induced microvascular senescence exacerbates cognitive impairment. In particular, findings suggest that targeting senescent endothelial cells through senolytic therapy can restore cerebrovascular function and improve cognitive outcomes in experimental models of atherosclerosis. Given the growing recognition of microvascular senescence as a therapeutic target, further research is warranted to explore novel interventions such as senolytics, anti-inflammatory agents, and metabolic modulators. The development of circulating biomarkers of vascular senescence (e.g., senescence-associated secretory phenotype [SASP] components and endothelial-derived extracellular vesicles) could enable early detection and risk stratification in individuals at high risk for VCI. Additionally, lifestyle modifications, including the Mediterranean diet, hold promise for delaying endothelial senescence and mitigating cognitive decline. In conclusion, cerebromicrovascular senescence is a key mechanistic link between atherosclerosis and cognitive impairment. Addressing microvascular aging as a modifiable risk factor through targeted interventions offers a promising strategy for reducing the burden of VCI and preserving cognitive function in aging populations.</p>","PeriodicalId":12730,"journal":{"name":"GeroScience","volume":"92 1","pages":""},"PeriodicalIF":5.6,"publicationDate":"2025-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143666374","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}