GeroScience最新文献

{"title":"Age-related changes in proprioception are of limited size, outcome-dependent and task-dependent.","authors":"Stien Van De Plas, Jean-Jacques Orban de Xivry","doi":"10.1007/s11357-025-02053-2","DOIUrl":"10.1007/s11357-025-02053-2","url":null,"abstract":"<p><p>Our ability to sense the position and movement of our limbs is essential for all activities of daily living. This ability arises from the signal sent by muscle spindles to the brain. While there is clear evidence for age-related changes in the quantity of muscle spindles and in their sensitivity, behavioral assessment of age-related changes in position sense have produced mixed findings even though it is taken as textbook knowledge that proprioception declines with age. Yet, study results are difficult to compare since there is no golden standard for assessment of proprioception. Therefore, we measured upper limb proprioception across several standard proprioceptive tasks together with key factors that could influence behavioral results such as touch, motor function, and cognition in 37 young (19-32 years old) and 35 older (53-71 years old) adults. We tested age-related differences in behavioral outcomes and their associations across tasks. Our results showed that age-related effects were variable, ranging from tasks where older participants performed better to tasks where they exhibit large age-related declines. Age-related declines in position sense are outcome-dependent, sometimes requiring large samples to detect small effects. The results were confirmed by meta-analysis based on data from hundreds of participants tested in our laboratory on the exact same tasks. Associations between outcome variables across or within proprioceptive tasks were overall negligible to weak. In conclusion, age-related changes in proprioception are limited in size, task- and outcome-dependent, and current tasks used to assess proprioception do not provide consistent evidence of age-related impairment in upper limb proprioception.</p>","PeriodicalId":12730,"journal":{"name":"GeroScience","volume":" ","pages":"8229-8263"},"PeriodicalIF":6.0,"publicationDate":"2026-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13638832/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146118785","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Frailty and postoperative risk in geriatric neurosurgery: a prospective cohort study using multidimensional assessment.","authors":"Chukwuma Okoye, Valentina Stella, Louis-Georges Roumy, Chiara Benedetta Rui, Alice Margherita Ornago, Paola Signorelli, Benedetta Maisano, Beatrice Tonus, Alberto Finazzi, Maria Cristina Ferrara, Elena Pinardi, Carlo Giorgio Giussani, Giuseppe Bellelli","doi":"10.1007/s11357-025-02088-5","DOIUrl":"10.1007/s11357-025-02088-5","url":null,"abstract":"<p><p>Frailty is increasingly recognized as a major determinant of surgical risk in older adults; however, its prognostic significance in the context of elective neurosurgery remains unclear. This study investigated the prevalence of frailty, the concordance between three validated frailty instruments, and their association with postoperative complications. A prospective cohort study was conducted at a tertiary neurosurgical center from November 2021 to November 2024. Patients aged ≥ 65 years undergoing elective cranial or spinal surgery were included. Preoperative frailty was assessed using the Clinical Frailty Scale (CFS), the Comprehensive Geriatric Assessment Frailty Index (CGA-FI), and the Fried's Frailty Phenotype (FFP) criteria. Postoperative complications-including infectious, cardiovascular, neurological, haemorrhagic events, delirium, and in-hospital death-were systematically recorded. Associations with frailty were examined using multivariable logistic regression adjusted for covariates. Among 181 patients (mean age, 74.1 [SD] 6.1 years), frailty prevalence ranged from 23.8% (CGA-FI) to 44.2% (FFP). Agreement between instruments was variable, with substantial concordance between CFS and CGA-FI (κ = 0.65) and only moderate concordance with FFP. Postoperative complications occurred in 47 (25.9%) patients. Frailty defined by CFS (adjusted odds ratio [aOR], 2.73; 95% CI, 1.05-7.42) and CGA-FI (aOR, 3.78; 95% CI, 1.34-11.1) was independently associated with increased risk of complications. In conclusion, frailty as assessed by the CFS and CGA-FI, is a strong determinant of postoperative risk in older adults undergoing elective neurosurgery. Incorporating frailty assessment into routine neurosurgical pathways may improve perioperative risk stratification and guide clinical decision-making.</p>","PeriodicalId":12730,"journal":{"name":"GeroScience","volume":" ","pages":"7795-7803"},"PeriodicalIF":6.0,"publicationDate":"2026-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13638885/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145917474","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cardiorespiratory fitness in relation to cerebral vascular and metabolic health in older adults with coronary artery disease.","authors":"Safa Sanami, Stéfanie A Tremblay, Zacharie Potvin-Jutras, Ali Rezaei, Dalia Sabra, Christine Gagnon, Brittany Intzandt, Amélie Mainville-Berthiaume, Lindsay Wright, Mathieu Gayda, Josep Iglesies-Grau, Anil Nigam, Louis Bherer, Claudine J Gauthier","doi":"10.1007/s11357-026-02128-8","DOIUrl":"10.1007/s11357-026-02128-8","url":null,"abstract":"<p><p>This study investigated whether higher cardiorespiratory fitness (VO₂peak) is associated with better cerebral vascular and metabolic health-specifically cerebral blood flow (CBF), cerebrovascular reactivity (CVR), cerebral metabolic rate of oxygen (CMRO₂), and oxygen extraction fraction (OEF) across healthy older adults and patients with coronary artery disease (CAD). Thirty-seven healthy adults (65.3 ± 8.3 years old) and 35 CAD patients (66.4 ± 9.3 years old) underwent calibrated fMRI using hypercapnic and hyperoxic gas challenges (including carbogen) to quantify gray matter CBF, CVR, CMRO₂, and OEF. VO₂peak was obtained from a maximal cycle ergometer cardiopulmonary exercise test. Associations between VO₂peak and brain biomarkers were evaluated with group terms to test CAD-specific effects. Across all participants, VO₂peak was positively associated with CBF (β = 0.32, p = 0.02) and CVR (β = 0.002, p = 0.04) in gray matter, indicating an association between aerobic fitness and vascular health. Metabolic effects differed by group: in CAD patients, VO₂peak correlated positively with CMRO₂ (β = 0.08, p = 0.02), suggesting higher fitness may be associated with preserved oxidative metabolism, while in healthy controls, VO₂peak was negatively associated with OEF (β = -3.6, p = 0.02), consistent with aging-related adaptations driven by improved CBF without CMRO₂ changes. VO₂peak is positively associated with cerebral vascular function in older adults and shows group-specific metabolic benefits: in CAD, higher VO₂peak relates to preserved CMRO₂, whereas in healthy individuals it is linked primarily to enhanced perfusion and reduced extraction. These findings support aerobic exercise as a promising strategy to mitigate CAD-related brain alterations and highlight VO₂peak as a potentially modifiable target for prevention and rehabilitation.</p>","PeriodicalId":12730,"journal":{"name":"GeroScience","volume":" ","pages":"8449-8465"},"PeriodicalIF":6.0,"publicationDate":"2026-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13638834/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146179052","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Low-dose tamoxifen ameliorates ovariectomy-induced metabolic and immune dysfunction.","authors":"Heather E McClurg, Amanda Ferraro, Gina Pham, Itzel Morales-Hernandez, Estefania Valencia-Rincon, Kevin D Pham, Willard M Freeman, Jacquelyn A Gorman, Marisol Castillo-Castrejon","doi":"10.1007/s11357-025-02086-7","DOIUrl":"10.1007/s11357-025-02086-7","url":null,"abstract":"<p><p>The decline in estrogen following menopause is a major driver of metabolic and immune dysfunction in aging females. While hormone replacement therapy improves many of these outcomes, its clinical use remains limited due to concerns regarding estrogen-sensitive malignancies. Tissue-selective estrogen complexes (TSECs), which combine estrogens with selective estrogen receptor modulators (SERMs) such as tamoxifen (TAM), represent a promising strategy to preserve the metabolic and immunological benefits of estrogen while reducing oncogenic risk. However, the systemic effects of TAM under conditions of estrogen deficiency remain incompletely defined. In this study, we investigated the metabolic and immunomodulatory actions of low-dose TAM, alone or in combination with 17β-estradiol (E2), in adult ovariectomized (OVX) female mice. OVX resulted in increased adiposity, hepatic steatosis, glucose intolerance, insulin resistance, immunoglobulin G3 (IgG3) concentration, and systemic inflammation, along with decreased immunoglobulin G1 (IgG1) concentration. E2, TAM, and E2 + TAM each attenuated OVX-induced adipose expansion, adipocyte hypertrophy, and proinflammatory cytokine production. TAM improved insulin sensitivity but did not fully restore glucose tolerance. Transcriptomic analysis of visceral adipose tissue-resident B cells revealed that E2 and E2 + TAM modulate overlapping yet distinct immune-regulatory networks, including suppression of pro-inflammatory signaling, regulation of immune checkpoints, and genes linked to adipose homeostasis. Low-dose TAM emerges as a modulator of estrogen receptor signaling that attenuates multiple features of OVX-induced metabolic and inflammatory dysfunction, though its limited effect on glycemic control highlights the need for tissue-specific evaluation of SERM-based interventions. These findings provide mechanistic insight into endocrine-immune-metabolic interactions and inform strategies to reduce aging-related disease risk in postmenopausal women.</p>","PeriodicalId":12730,"journal":{"name":"GeroScience","volume":" ","pages":"8413-8434"},"PeriodicalIF":6.0,"publicationDate":"2026-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13638879/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146156839","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Whole blood transcriptional signatures of age and survival identified in long life family and integrative longevity omics studies.","authors":"Mengze Li, Zeyuan Song, Eric Reed, Tanya T Karagiannis, Stacy Andersen, Michael Brent, Chase Mateusiak, Sandeep Acharya, Wooseok J Jung, Shu Liao, Mary K Wojczynski, Mary F Feitosa, Jeffrey R O'Connell, May E Montasser, Roland J Thorpe, Konstantin Arbeev, Sofiya Milman, Albert Tai, Thomas T Perls, Paola Sebastiani, Stefano Monti","doi":"10.1007/s11357-025-02090-x","DOIUrl":"10.1007/s11357-025-02090-x","url":null,"abstract":"<p><p>Although aging is a universal event, some individuals are able to achieve extreme longevity. The Long-Life Family Study (LLFS) enrolls participants from families enriched with long-lived individuals, serves as a valuable dataset for studying ageing phenotypes and identify potential intervention targets. We analyzed the association between age at blood draw and 16,284 RNAseq-based blood transcriptomic data from 2,167 LLFS participants with ages ranging from 18 to 107, replicated the results in the Integrative Longevity Omics Study (ILO) dataset of 20,884 RNAseq-based blood transcriptomic data from 419 participants, with ages ranging from 60 to 108, and further compared our findings to a published reference aging signature. We identified 4,227 transcripts increasing and 4,044 transcripts decreasing with age, and enrichment analysis revealed age-related upregulation of inflammatory and senescence-related pathways, and downregulation of MYC and Wnt/β-catenin targets, among others. Further, a subset of transcripts showed age associations unique to the longevity-enriched cohorts (LLFS and ILO). We also identified 314 transcripts significantly associated with mortality risk and found that pro-survival gene sets included NK cell-mediated cytotoxicity and GPCR signaling. Finally, increased transcriptomic age predicted using transcriptomic clock was strongly associated with increased mortality. In summary, this study identified robust transcriptomic signatures of aging and mortality in a longevity-enriched population, highlighting key biological pathways such as immune modulation, inflammation, and senescence.</p>","PeriodicalId":12730,"journal":{"name":"GeroScience","volume":" ","pages":"8621-8639"},"PeriodicalIF":6.0,"publicationDate":"2026-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13638853/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146776338","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sex and APOE genotype specific brain regional vulnerability to Alzheimer's Disease.","authors":"Qi Zeng, Minghui Wang, Erming Wang, Xianxiao Zhou, Peng Xu, Vahram Haroutunian, Dongming Cai, Bin Zhang","doi":"10.1007/s11357-025-02089-4","DOIUrl":"10.1007/s11357-025-02089-4","url":null,"abstract":"<p><p>Alzheimer's disease (AD) disproportionately affects women and carriers of the apolipoprotein E ε4 allele (APOE4), yet little is known about how sex and APOE interact to influence white matter (WM) integrity during disease progression. We integrated diffusion MRI and matched blood transcriptomic data to investigate these interactions and their underlying biological mechanisms. WM microstructure was quantified using diffusion tensor imaging (DTI) and neurite orientation dispersion and density imaging (NODDI), and regional vulnerability was assessed with a composite vulnerability score (CVS) derived from associations between diffusion features and AD severity across clinical traits in each of the four sex-APOE groups (female or male, with or without APOE4). Brain parcellation with the Eve atlas revealed regions consistently affected across sex-APOE groups (e.g., parahippocampal and superior temporal gyri) and regions specific to individual groups (e.g., the cingulum in females with APOE4 and the middle frontal gyrus in males without APOE4). Gene co-expression network analysis of the matched blood expression data identified gene subnetworks linked to group-specific regional vulnerability, including a muscle tissue morphogenesis module regulated by NEURL1B and HIST1H2BN associated with middle frontal gyrus vulnerability. These findings demonstrate that sex and APOE genotype jointly shape region-specific WM vulnerability and its molecular signatures in AD. Understanding these interactions provides novel mechanistic insights and may inform precision approaches to drug development, biomarker discovery, and clinical trial design for AD.</p>","PeriodicalId":12730,"journal":{"name":"GeroScience","volume":" ","pages":"8591-8608"},"PeriodicalIF":6.0,"publicationDate":"2026-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13638851/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146219508","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"p38 MAPK and MDT-15 mediate SKN-1-dependent metformin-induced protection against mitis group streptococci in Caenorhabditis elegans.","authors":"Ali Al Hatem, Boopathi Balasubramaniam, Alissa Villhauer, Ali K Naji, Ransome van der Hoeven","doi":"10.1007/s11357-026-02405-6","DOIUrl":"10.1007/s11357-026-02405-6","url":null,"abstract":"<p><p>Mitis group streptococci are opportunistic pathogens residing in the oral cavity, where they produce hydrogen peroxide (H₂O₂), a key virulence factor contributing to their pathogenesis. We previously demonstrated that these bacteria kill the nematode Caenorhabditis elegans through H₂O₂ production. Metformin, a widely used biguanide drug for managing blood glucose levels, has shown promising effects on aging by extending lifespan in worms and mice, and has also demonstrated potential cancer treatment. Additionally, pretreatment with metformin enhances the survival of worms and triggers an immune response via the p38 MAPK pathway against various pathogenic bacteria. Based on these observations, we investigated metformin's potential as a therapeutic agent against mitis group streptococcal infections and its underlying mechanisms in the current study. Pretreatment of worms with metformin provided significant dose-dependent protection from streptococcal-derived H₂O₂. This protective effect was attributed to the activation of the oxidative stress response transcription factor SKN-1/NRF2. Further analysis revealed that the p38 MAPK pathway and the transcription mediator complex protein MDT-15 are essential for the activation of SKN-1 by metformin. Interestingly, SKN-1 activity, mediated by MDT-15, was found to be independent of the p38 MAPK pathway. Our findings establish that metformin-mediated protection against mitis group streptococcal infections relies on the coordinated action of SKN-1, the p38 MAPK pathway, and MDT-15. These insights suggest that metformin could be a valuable therapeutic agent in combating these infections. Future research should focus on further elucidating the molecular mechanisms involved and exploring the potential clinical applications of metformin in treating these bacterial infections.</p>","PeriodicalId":12730,"journal":{"name":"GeroScience","volume":" ","pages":"7505-7522"},"PeriodicalIF":6.0,"publicationDate":"2026-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13638828/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148591305","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Lifestyle for Brain health (LIBRA) score, cognition, brain volume, and dementia risk in the UK Biobank.","authors":"Kelsey R Sewell, James D Doecke, Samantha L Gardener, Blossom Stephan, Kirk I Erickson, Belinda M Brown","doi":"10.1007/s11357-025-02056-z","DOIUrl":"10.1007/s11357-025-02056-z","url":null,"abstract":"<p><p>A substantial proportion of dementia risk may be attributable to modifiable factors, yet these are often examined in isolation despite their interrelated nature and tendency to co-occur. It remains unclear whether the relationship between modifiable factors and dementia risk is influenced by individual characteristics such as sex and genetic susceptibility. We investigated longitudinal associations between the Lifestyle for Brain health (LIBRA) score and risk of dementia, cognitive performance, and brain structure, and whether relationships differed by sex and APOE ɛ4 carrier status.Participants were aged > 50 years, dementia-free at baseline, 50% female and predominantly (97%) white/Caucasian. The LIBRA score included 11 modifiable factors (e.g., hypertension, obesity, physical inactivity). Magnetic resonance imaging estimated brain volume, domain-specific cognitive composite scores were calculated, and dementia diagnoses were determined based on self-reported and linked healthcare data.Across a mean follow-up of 10.2 years, a higher LIBRA score was associated with greater odds of developing dementia (OR = 1.20, 95% CI 1.18-1.22). This association was stronger in APOE ɛ4 non-carriers compared to ɛ4 carriers. Cross-sectionally, higher LIBRA scores related to poorer cognition, smaller whole-brain gray and white matter volumes, and increased ventricular cerebrospinal fluid (CSF), however, only the association with increased ventricular CSF persisted longitudinally (mean follow-up 3.4 years).Each one-point increase on the LIBRA score was associated with 20% increased odds of developing dementia. These results reinforce the need to target modifiable dementia risk factors and to tailor dementia prevention strategies to individual risk profiles to maximize the impact on brain health.</p>","PeriodicalId":12730,"journal":{"name":"GeroScience","volume":" ","pages":"7757-7767"},"PeriodicalIF":6.0,"publicationDate":"2026-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13638863/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145917639","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Differences across males and females in cognitive aging and mortality risk: a trajectory-based approach.","authors":"Elena Lobo, Concepción De la Cámara, Patricia Gracia-García, Raúl López-Antón, Pedro Saz, David Vaquero-Puyuelo, Antonio Lobo","doi":"10.1007/s11357-026-02145-7","DOIUrl":"10.1007/s11357-026-02145-7","url":null,"abstract":"<p><p>This study examined hypothesized differences across males and females in the relationship between cognitive trajectories and mortality in older adults. Data were drawn from the ZARADEMP study on dementia and depression in adults aged 55 and older in Zaragoza, Spain. A total of 2403 cognitively healthy individuals who completed at least three of four waves over a 12-year follow-up were included. Cognitive trajectories were derived from Mini-Mental State Examination (MMSE) scores. Using growth mixture modeling (GMM), four trajectories in men and three in women were previously identified. Mortality data, obtained from official records, covered up to 6 years after the final wave. Cox proportional hazards models assessed mortality risk across trajectories, adjusting for sociodemographic, medical, and lifestyle factors. Mortality was higher among participants with steeper cognitive decline in both sexes. In men, those in the declining-low and stable-medium trajectories had 133% and 36% higher mortality risk, respectively, compared to the stable-high group. In women, declining-low and stable-medium classes had 133% and 30% increased risk, respectively. The association in women followed a clear gradient; in men, this pattern was absent. Differences in mortality predictors were identified: medical conditions (e.g., hypertension, diabetes, alcohol use) were significant only in men, whereas psychosocial and functional variables (e.g., anxiety, ADL dependency, marital status) were significant only in women. This is the first report showing differences across males and females in the association between cognitive decline trajectories and mortality. Sex-specific strategies may be needed to mitigate mortality associated with trajectories of cognitive decline.</p>","PeriodicalId":12730,"journal":{"name":"GeroScience","volume":" ","pages":"8491-8503"},"PeriodicalIF":6.0,"publicationDate":"2026-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13638808/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146194450","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pro-longevity compounds extend Caenorhabditis elegans male lifespan and reproductive healthspan.","authors":"Rose S Al-Saadi, Patrick C Phillips","doi":"10.1007/s11357-026-02144-8","DOIUrl":"10.1007/s11357-026-02144-8","url":null,"abstract":"<p><p>Sex differences in aging are robust and ubiquitous. Demographic differences in aging generated by sex have long been recognized, but the underlying biological basis for these differences and the potential for sex-specific interventions remain understudied. To explore sex differences in the response to pro-longevity interventions, we utilized the C. elegans aging model and asked whether male lifespan and reproductive healthspan can be extended via compounds known to have pro-longevity effects in hermaphrodites. We tested seven different compounds at two concentrations each and found that lifespan was extended under all tested conditions. However, reproductive healthspan measured by mating success in late life improved under only two tested conditions, sulforaphane and metformin. These results demonstrate that lifespan and healthspan can be decoupled in C. elegans males and offer a new framework for screening pro-longevity compounds and for studying sex differences in aging in a classical aging model.</p>","PeriodicalId":12730,"journal":{"name":"GeroScience","volume":" ","pages":"8519-8530"},"PeriodicalIF":6.0,"publicationDate":"2026-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13638962/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146212958","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}