GeroScience最新文献

{"title":"Spinal augmentation for vertebral body fractures in the elderly population.","authors":"Alexander R Evans,Taylor Niznik,Chao Li,Zachary A Smith","doi":"10.1007/s11357-025-01842-z","DOIUrl":"https://doi.org/10.1007/s11357-025-01842-z","url":null,"abstract":"Osteoporotic vertebral body fractures (OVBFs) are a highly prevalent pathology in the United States elderly population and can result in height loss and kyphotic deformity. While minimally invasive surgical techniques such as percutaneous kyphoplasty (PKP) and vertebroplasty (PVP) are commonly used, the efficacy of these techniques in older individuals is unknown. By examining the current body of evidence, we aim to assess the efficacy of these procedures within the context of appropriate grading of levels of evidence. This narrative review was conducted by searching multiple databases, including articles pertaining to vertebral augmentation procedures in elderly patients. Articles were then graded for levels of evidence, as outlined by the Oxford Centre for Evidence-Based Medicine (OCEBM). Literature suggests that both procedures are generally safe in advanced-age patients, can reliably and sustainably decrease pain, and may be augmented with a multitude of adjunctive/perioperative care options. Such efforts include pedicle screw fixation with or without fusion, intraoperative lidocaine injection, erector spinae plane block, and rehabilitation efforts, in addition to the use of dexmedetomidine or the combined use of remimazolam besylate and sufentanil analgesics. The most dreaded complications of both procedures are bone cement extravasation and refracture, which likely occur more frequently after PKP. Both procedures have demonstrated efficacy in the domain of anatomical correction. PKP and PVP appear to safely restore quality of life in elderly patients, yet the finer details of each procedure must be explored with higher levels of evidence to account for potential differences in complication profiles and care options.","PeriodicalId":12730,"journal":{"name":"GeroScience","volume":"170 1","pages":""},"PeriodicalIF":5.6,"publicationDate":"2025-09-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145043690","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association and predictive values of nine biological age measures for cardiovascular disease mortality: screening and validation from two prospective cohort studies.","authors":"Solim Essomandan Clémence Bafei,Hankun Xie,Song Yang,Junxiang Sun,Yu Liu,Yao Fan,Wei Tang,Jiahui Liu,Changying Chen,Chong Shen","doi":"10.1007/s11357-025-01866-5","DOIUrl":"https://doi.org/10.1007/s11357-025-01866-5","url":null,"abstract":"Biological age (BA) reflects the aging process more accurately than chronological age. This study aimed to evaluate the associations and predictive values of nine BA measures for mortality outcomes. BA measures were developed using data from the Yixing Cohort Study (YCS; N = 4,128) and externally validated in the Jurong Cohort Study (JCS; N = 16,652). Dose-response relationships between the clinical indices and all-cause death were assessed using restricted cubic spline analysis. Statistically significant predictors were then integrated into BA estimates using nine different algorithms. The difference between BA and chronological age, termed delta age (DA), was calculated, and its association with mortality outcomes was assessed using Cox proportional hazards models. The hazard ratios (HRs) of the association of the nine DAs with mortality were greater for CVD death than all-cause death, with the DA derived from the Klemera and Doubal Method 2 (KDM2) showing the strongest association with CVD death (YCS: HR(95% CI) = 1.325 (1.060-1.656); JCS: HR(95% CI) = 1.167(1.101-1.236); P < 0.05) and all-cause death (YCS: HR(95% CI) = 1.203(1.075-1.346); JCS: HR(95% CI) = 1.089 (1.050-1.129); P < 0.05). Incorporating KDM2-based DA into the traditional risk factors model significantly improved the prediction of CVD death, as reflected by net reclassification improvement (YCS: NRI = 7.9%; JCS: NRI = 9.1%; P < 0.001) and integrated discrimination improvement (YCS: IDI = 0.4%; JCS: IDI = 0.7%; P < 0.001). Our findings support that KDM2-based aging measures could serve as a complementary tool for identifying people at high risk of CVD events and all-cause death.","PeriodicalId":12730,"journal":{"name":"GeroScience","volume":"55 1","pages":""},"PeriodicalIF":5.6,"publicationDate":"2025-09-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145043691","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Enhancing peripheral nerve regeneration in aging: the role of Schwann cells, c-Jun, and emerging therapeutic strategies.","authors":"Melod Mehdipour,Vanshit Thakkar,Stephano Chang","doi":"10.1007/s11357-025-01882-5","DOIUrl":"https://doi.org/10.1007/s11357-025-01882-5","url":null,"abstract":"Peripheral nerve injuries (PNI) present a significant challenge, particularly in aging populations where Schwann cell dysfunction, reduced c-Jun expression, increased senescence, and impaired myelin clearance hinder regeneration. Targeted therapies aim to restore Schwann cell plasticity and improve nerve repair. These include gene therapy to upregulate c-Jun, senolytic agents to eliminate senescent Schwann cells, pharmacological activation of JNK, ferroptosis inhibition, and stem cell-based transplantation. Biomaterial advancements, such as nerve guidance conduits, extracellular matrix hydrogels, and 3D-printed scaffolds, provide structural and biochemical support. Despite these advances, clinical translation remains challenging due to patient heterogeneity, the need for personalized approaches, and regulatory considerations. Integrating multimodal strategies holds promise for optimizing peripheral nerve repair in aging individuals. Future research must refine these therapies to develop clinically viable solutions that enhance functional recovery and improve quality of life for patients with PNI.","PeriodicalId":12730,"journal":{"name":"GeroScience","volume":"75 1","pages":""},"PeriodicalIF":5.6,"publicationDate":"2025-09-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145036120","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Phenotypic age acceleration as a novel predictor of benign prostatic hyperplasia: a prospective cohort study.","authors":"Xuwen Li,Penghu Lian,Hongyan Chen,Liangzhe Zhang,Zhe Zhang,Jing Wang,Nianzeng Xing,Tao Jiang,Ziwei Chen,Xinlei Zhang,Xiongjun Ye","doi":"10.1007/s11357-025-01846-9","DOIUrl":"https://doi.org/10.1007/s11357-025-01846-9","url":null,"abstract":"This study aims to investigate the predictive value of combined phenotypic age and phenotypic age acceleration (PhenoAgeAccel) for benign prostatic hyperplasia (BPH) and develop a machine learning-based risk prediction model to inform precision prevention and clinical management strategies. The study analyzed data from 784 male participants in the US National Health and Nutrition Examination Survey (NHANES, 2001-2008). Phenotypic age was derived from chronological age and nine serum biomarkers. PhenoAgeAccel, representing biological aging acceleration, was calculated as the residual from regressing phenotypic age on chronological age. Recursive Feature Elimination (RFE) identified 34 BPH-associated features, which were integrated into an XGBoost prediction model. Logistic regression evaluated PhenoAgeAccel-BPH associations, while SHapley Additive exPlanations (SHAP) quantified feature contributions to enhance model interpretability. The XGBoost model achieved an area under the curve (AUC) of 0.833 in the test set. Phenotypic age was strongly correlated with chronological age (r = 0.833), and individuals with PhenoAgeAccel exhibited a significantly elevated risk of BPH (p < 0.001). Adjusting the model with phenotypic age improved predictive performance (AUC = 0.853). SHAP analysis identified phenotypic age as the third most influential predictor (after trailing cancer history and lead exposure), highlighting its clinical relevance. Chronological age and serum biomarkers are critical predictors of BPH, while PhenoAgeAccel independently contributes to risk stratification. Integrating phenotypic age with machine learning provides a robust framework for the early detection of BPH and personalized risk assessment, aligning with advancements in aging biomarker research. This approach supports targeted interventions to mitigate BPH progression in aging populations.","PeriodicalId":12730,"journal":{"name":"GeroScience","volume":"70 1","pages":""},"PeriodicalIF":5.6,"publicationDate":"2025-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145032105","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of age and musical training on resting-state periodic oscillatory brain activity.","authors":"Sijia Guo,Ning Li,Liju Wang,Chenxi Qiu,Yuxin Chen,Yitian Yin,Hua Yang,Claude Alain,Jing Lu,Dezhong Yao","doi":"10.1007/s11357-025-01862-9","DOIUrl":"https://doi.org/10.1007/s11357-025-01862-9","url":null,"abstract":"Neural oscillations comprise periodic and aperiodic components, which have been linked to cognitive functions. Changes in oscillatory activity as a function of age and musical training may related to cognitive decline and the protective effects of lifelong musical training. However, there are inconsistencies in prior studies assessing the changes in alpha oscillations with age and musical training experience, which did not consider the putative impact of the aperiodic activity. In this study, we recruited young and older musicians and non-musicians, comparing resting state alpha oscillations before and after correcting for aperiodic activity. We observed an age-related decline in alpha power in uncorrected and corrected periodic activities. Nonetheless, the protective effect of musical training on this decline was only evident in the corrected periodic activities, highlighting the importance of correcting for aperiodic activity. This was related to better performance in working memory tasks in older musicians compared with older non-musicians. Our findings provide mechanistic insights into how long-term musical training decelerates age-related working memory decline. It has implications for understanding the neuroplasticity of musical training on cognitive aging.","PeriodicalId":12730,"journal":{"name":"GeroScience","volume":"38 1","pages":""},"PeriodicalIF":5.6,"publicationDate":"2025-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145032103","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of hearing ability on inflammation and glymphatic function affecting cognition in older adults.","authors":"Weijie Ye,Chunhua Xing,Jun Yao,Xiaomin Xu,Zihuai Fang,Xindao Yin,Richard Salvi,Yu-Chen Chen,Yuexin Cai","doi":"10.1007/s11357-025-01880-7","DOIUrl":"https://doi.org/10.1007/s11357-025-01880-7","url":null,"abstract":"The mechanisms linking hearing ability, inflammation, glymphatic system function, and cognitive impairment in older adults are largely unknown. To investigate this issues, magnetic resonance imaging (MRI) was used to test for dysfunctions in the glymphatic system of older adults with hearing loss and to determine the relationship of glymphatic dysfunction, inflammation and cognitive deficits. This cross-sectional observational study included participants with ARHL and healthy controls (HCs) between January 2021 and December 2023. Participants underwent MRI scans of the glymphatic indices and clinical assessment of auditory, neuropsychological, and inflammatory measures. Multimodal MRI indices were used as proxies of glymphatic function and compared with measures of inflammation and cognition dysfunction in the older adults with hearing loss and control groups. Mann-Whitney U test, Spearman rank correlation and Mediation analysis were conducted. A total of 130 hearing loss patients (mean age years, 64.10 ± 3.43 [SD], 67 males) and 121 healthy controls (mean age years, 63.55 ± 3.49 [SD], 68 males) were included. The hearing loss group differed significantly from normal hearing control on MRI glymphatic measures of choroid plexus volume (CPV) (1.48 vs 1.37, p = 0.0004), enlarged perivascular spaces (EPVS) (1.74 vs 1.55, p < 0.0001) and diffusion tensor image analysis along the perivascular space (DTI-ALPS) (1.47 vs 1.63, p < 0.0001). Hearing loss severity was associated with higher values of CPV and EPVS and lower values of ALPS and strongly correlated with higher levels of inflammation (all FDR q < 0.05). Mediation analysis showed that ALPS and CPV mediate the relationship between hearing loss and scores on the Montreal Cognitive Assessment (MoCA) and Digit Symbol Substitution Test (DSST), respectively. Our findings support a potential associative pathway that inflammation and glymphatic dysfunction act as plausible intermediate factors facilitating the pathological relationship linking the increase in hearing loss in older adults to decline in cognition.","PeriodicalId":12730,"journal":{"name":"GeroScience","volume":"138 1","pages":""},"PeriodicalIF":5.6,"publicationDate":"2025-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145032104","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Increasing indices of frailty in aged female mice are associated with impaired skeletal muscle resilience to downhill running stress.","authors":"Grant R Laskin,Laís R Perazza,Ted G Graber,Baylah R Mazonson,Yuhoung J Kim,Laura J Verdi,LaDora V Thompson","doi":"10.1007/s11357-025-01856-7","DOIUrl":"https://doi.org/10.1007/s11357-025-01856-7","url":null,"abstract":"Frailty is a clinical syndrome marked by diminished physiological reserve and function. While skeletal muscle dysfunction is central to frailty, most preclinical models focus on basal function and place less emphasis on physiological stress responses. Here, we examined the influence of increased indices of frailty on skeletal muscle resistance and resilience using a physiologically relevant model of downhill running stress. Aged female C57BL/6JN mice (n = 47; > 17 months) were stratified into Low (≤ 1 frailty markers) or High (≥ 2 frailty markers) groups based on their number of positive frailty markers. Mice were subsequently randomized to undergo two bouts of downhill running or remain cage sedentary. Twenty-four hours later, contractile function was assessed ex vivo in the extensor digitorum longus (EDL) and soleus muscles. RNA was extracted from the gastrocnemius of randomly selected samples and analyzed by RNA sequencing. Despite comparable specific tetanic force, High frailty marked mice exhibited greater fatiguability and impaired recovery kinetics in the EDL following running stress. RNA sequencing revealed divergent transcriptional signatures between mice in Low and High frailty marked groups in response to running, including upregulation of mitochondrial bioenergetic and complex assembly pathways in Low group mice and downregulation in High group mice. These data demonstrate that downhill running stress unmasks latent impairments with frailty in skeletal muscle, and that mitochondrial dysfunction and/or redox imbalance may be potential contributors to reduced muscle resilience. Overall, our results emphasize the importance of incorporating physiological stress paradigms to uncover frailty-associated muscle impairments that are not apparent under basal conditions.","PeriodicalId":12730,"journal":{"name":"GeroScience","volume":"74 1","pages":""},"PeriodicalIF":5.6,"publicationDate":"2025-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145032156","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A simplified clinical frailty scale predicts mortality in emergency department patients with acute dyspnea.","authors":"Ahmad Zwawi,Torgny Wessman,Per Wändell,Olle Melander,Axel C Carlsson,Toralph Ruge","doi":"10.1007/s11357-025-01864-7","DOIUrl":"https://doi.org/10.1007/s11357-025-01864-7","url":null,"abstract":"To evaluate a simplified version of the Clinical Frailty Scale (SCFS) among older adults presenting to the emergency department (ED) with acute dyspnea. In this retrospective single-center cohort study, we included patients from the Acute Dyspnea Study (ADYS) cohort. Severity of illness was assessed using the Medical Emergency Triage and Treatment System (METTS). SCFS was operationalized using existing data on municipal care services from the ADYS database and divided into three levels. SCFS 1: Not frail patients with no need for municipal care services, SCFS 2: Patients with municipal care services, including home care, and SCFS 3: Patients with residence in a short-term care facility or nursing home. The primary outcome was 90-day mortality and hospitalization. Multivariable Cox and logistic regression analyses were used to assess associations between SCFS and outcome variables. SCFS criteria were met in 35.2% of patients (668 patients, SCFS group 2 and 3). These individuals had a higher comorbidity burden and increased 90-day mortality (20.9%, p < 0.001). SCFS group 3 was independently associated with a higher risk of 90-day mortality (HR = 2.60, 95% CI: 1.27-5.29, p = 0.009), compared to group 1. ROC curve analysis showed that combining SCFS with METTS significantly improved predictive performance (DeLong's test: p = 0.015 and p = 0.0322 in respective models). For hospitalization, SCFS group 3 was associated with hospitalization independent of age, sex, BMI, comorbidities, and readmission, when compared to SCFS group 1 (OR = 2.57, CI:1.11-6.71, p = 0.037). This association was attenuated and nonsignificant after further adjustment for METTS. SCFS is an independent predictor of 90-day mortality in older ED patients with acute dyspnea. When combined with triage scores like METTS, its predictive value improves. These findings support the potential clinical utility of incorporating frailty assessment into ED triage to aid risk stratification and guide care decisions.","PeriodicalId":12730,"journal":{"name":"GeroScience","volume":"33 1","pages":""},"PeriodicalIF":5.6,"publicationDate":"2025-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145032122","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Slowing down the clock on ovarian aging-does the ovary hold the secret to the fountain of youth?","authors":"Paula Benny,Xi Yuan,Qian Yang,Jorge Chavarro,Brian Kennedy,Zhongwei Huang","doi":"10.1007/s11357-025-01876-3","DOIUrl":"https://doi.org/10.1007/s11357-025-01876-3","url":null,"abstract":"In the past century, the human Lifespan has doubled. However, this is not equivalent to Healthspan which refers to the number of years spent healthy and free from disease. Women have an additional level of complexity on the path to optimal healthspan where health resilience dramatically decreases following menopause and this is due to their ovaries aging by midlife. It still remains elusive on why and how the ovaries in women, albeit their distinct and vital reproductive functions, start to age before any other organs. Following menopause, women are at increased risks of age-associated chronic diseases such as cardiometabolic disease, osteoporosis, sarcopenia, frailty, and neurocognitive decline. By preserving reproductive longevity through targeting the ovary as the organ to rejuvenate in women, optimal healthspan could be obtained in women. Interestingly, population studies have shown that women who conceive naturally and give birth at advanced reproductive ages are demonstrated to have superior postmenopausal longevity. Correspondingly, men Lived longer with a sister reproducing after 45 years of age in natural fertility conditions, suggesting that late female fertility and slow somatic aging may be promoted by the same genetic variants. Causal inference analysis showed a link between increased reproductive lifespan (prolonged ovarian lifespan or later age at natural menopause) and a reduction of diseases such as diabetes and osteoporosis. Essentially, fewer ovarian follicles and shorter ovarian lifespan were associated with poorer health later in life. Therefore, innovative ways to understand and target the ovaries in women for gero-protection have the potential to avert aging diseases triggered by the female menopause. Our narrative review aims to integrate existing information from systemic and reproductive aging from preclinical and human studies to devise novel methodologies to avert ovarian aging which could potentially improve the health trajectory in aging women. Similar strategies can be applied to men to achieve healthy longevity in the population. While there are certain things one has little control over, such as genetics and the inevitable reduction of reproductive hormone levels over time, there are modifiable risk factors which can be targeted to preserve reproductive longevity by uniquely targeting the ovary especially in modifying and improving the ovarian microenvironment to ensure survival of the ovarian follicles which determine true reproductive lifespan and healthspan. This can be achieved by modifying diet, sleep patterns, and exercise and limiting toxin exposure to ensure optimal ovarian health, through healthy and functional ovarian follicles, which could bring us a step closer to enhancing women's healthspan and human longevity.","PeriodicalId":12730,"journal":{"name":"GeroScience","volume":"35 1","pages":""},"PeriodicalIF":5.6,"publicationDate":"2025-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145032124","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mild cognitive impairment impacts association of functional brain connectivity with cognition in older adults with and without multiple sclerosis.","authors":"Siddharth Nayak,Mark E Wagshul,Roee Holtzer","doi":"10.1007/s11357-025-01854-9","DOIUrl":"https://doi.org/10.1007/s11357-025-01854-9","url":null,"abstract":"Cognitive decline is common in multiple sclerosis (MS), although neural mechanisms are not fully understood. The objective was to investigate the impact of mild cognitive impairment (MCI) on the relationship between resting state functional connectivity (RSFC) and cognitive function in older adults with multiple sclerosis (OAMS) and age matched healthy controls. Participants underwent magnetic resonance imaging (MRI) scans and cognitive assessments. The Oral Symbol Digit Modalities Test (SDMT) was the outcome measure. Multiple linear regressions examined the relationship between RSFC networks and SDMT performance across the cohort and within group-specific analyses. These analyses were repeated with MCI as a moderator. Adjusted analyses showed that better SDMT performance correlated significantly with higher RSFC in sensorimotor (p = 0.01), left frontoparietal (p = 0.027), and salience (p = 0.047) networks. Stratified analyses showed significant positive associations for the OAMS group in medial visual (p = 0.007) and sensorimotor (p = 0.018) networks. Among OAMS, MCI moderated the association between RSFC and SDMT performance in the posterior default mode (p = 0.016) and subcortical (p = 0.042) networks, while no significant moderation effects were observed for the control group. Higher RSFC in brain networks correlates with better cognition in aging, but this relationship is modified in the presence of MS and MCI.","PeriodicalId":12730,"journal":{"name":"GeroScience","volume":"16 1","pages":""},"PeriodicalIF":5.6,"publicationDate":"2025-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145025472","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}