GeroScience最新文献

{"title":"Resistance training, but not leucine, increased basal muscle protein synthesis and reversed frailty in older women consuming optimized protein intake.","authors":"Kathryn J Jacob,Guy Hajj-Boutros,Vita Sonjak,Jean-Phillippe Leduc-Gaudet,Felipe Broering,Charles Robb Flynn,Stéphanie Chevalier,Marie Lamarche,Sabah N A Hussain,José A Morais","doi":"10.1007/s11357-025-01877-2","DOIUrl":"https://doi.org/10.1007/s11357-025-01877-2","url":null,"abstract":"Frailty, often linked to sarcopenia, involves reduced muscle strength and mass. While sarcopenia has multiple causes, impaired muscle protein synthesis may contribute. Leucine and resistance training (RT) are anabolic stimuli, but the long-term effects of leucine combined with RT in pre/frail older women remain unclear. This double-blind, placebo-controlled study aimed to assess their impact on muscle anabolism and characteristics in women consuming adequate protein. Pre/frail elderly women (n = 19, 77.5 ± 1.3 y, BMI: 25.1 ± 0.9 kg/m2), underwent 12 weeks of RT with protein-optimized diet (1.2 g⋅kg BW-1⋅d-1) and were randomized to 7.5 g/d of leucine (Leu) or placebo 5.1 g/d alanine (Ala). The primary outcome was myofibrillar fractional synthesis rate (MyoFSR) in the postabsorptive and postprandial states. Secondary outcomes are changes in protein content and expression, 1-repetition maximum, body composition (DXA), and myofiber profiles were investigated. Overall MyoFSR increased by 47%, with a concomitant increase in type 1 and 2a myofiber cross sectional area (CSA) (16% and 28%, respectively), and total lean mass (2%). Total AKT, S6, and AMPKα levels were unchanged. However, AKT and S6 phosphorylation increased postprandially before RT, with no change following RT. The number of Frailty Criteria was reduced by 64%, with improvements in physical function and strength. Leucine had no added anabolic benefit. RT with optimal protein intake significantly improved the Frailty Phenotype and increased basal MyoFSR along with type 1 and 2a myofiber CSA and total lean mass, with no added benefit of leucine supplementation.","PeriodicalId":12730,"journal":{"name":"GeroScience","volume":"35 1","pages":""},"PeriodicalIF":5.6,"publicationDate":"2025-09-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145025473","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Fluphenazine, an antipsychotic compound, ameliorates Alzheimer's disease by clearing amyloid beta accumulation in C. elegans.","authors":"Mayur Nimbadas Devare, Victoria Le, Vanessa Chung, T J Vu, Matt Kaeberlein","doi":"10.1007/s11357-025-01861-w","DOIUrl":"https://doi.org/10.1007/s11357-025-01861-w","url":null,"abstract":"<p><p>The aging population worldwide faces an increasing burden of age-related conditions, with Alzheimer's disease being a prominent neurodegenerative concern. Drug repurposing, the practice of identifying new therapeutic applications for existing drugs, offers a promising avenue for accelerated intervention. In this study, we utilized the yeast Saccharomyces cerevisiae to screen a library of 1760 FDA-approved compounds, both with and without rapamycin, to assess potential synergistic effects on yeast growth. We identified 87 compounds that showed synergistic effect with rapamycin and caused growth defects in yeast. Ten compounds from this list were further screened for their effects on paralysis in a Caenorhabditis elegans model of Alzheimer's disease. We found that three compounds synergistically delayed paralysis in combination with rapamycin, suggesting a potential functional redundancy or pathway convergence with mTOR signaling. Additionally, four other compounds delayed paralysis when tested at different concentrations. Moreover, we tested fluphenazine, an antipsychotic drug identified in our screen and found that it enhanced the overall health of treated worms. Western blot and X-34 staining confirmed that fluphenazine reduced amyloid-beta accumulation. Although these findings were obtained in yeast and C. elegans models, further validation in mammalian systems is required to confirm their translational relevance. Nevertheless, the results underscore the significant potential of repurposed drugs to accelerate the discovery of therapeutics for Alzheimer's disease.</p>","PeriodicalId":12730,"journal":{"name":"GeroScience","volume":" ","pages":""},"PeriodicalIF":5.4,"publicationDate":"2025-09-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145029470","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between overweight/obesity and oral health in adults aged 55 and older: a systematic review and meta-analysis.","authors":"Maryam Raoof,Sami Al Chafi,Hamid Reza Tohidinik,Ralph de Vries,Frank Lobbezoo","doi":"10.1007/s11357-025-01849-6","DOIUrl":"https://doi.org/10.1007/s11357-025-01849-6","url":null,"abstract":"The increasing prevalence of overweight/obesity among the elderly has significant implications for oral health due to shared pathophysiological mechanisms. Despite its importance, comprehensive reviews on this topic remain limited. This study investigates the association between overweight/obesity and oral health outcomes in adults aged 55 and older. This systematic review followed PRISMA guidelines and was registered with PROSPERO (CRD42020202108). A systematic literature search was conducted across PubMed, Embase.com, CINAHL, and Web of Science up to November 6, 2023. The study was structured using the Population, Intervention/Exposure, Comparison, Outcome, and Study Design (PICOS) criteria: Population (P) included adults aged ≥ 55 years; Intervention/Exposure (I/E) involved overweight/obesity; Comparison (C) included normal-weight individuals; Outcomes (O) focused on periodontal diseases, dental caries, tooth wear, and orofacial pain; and Study design (S) included case-control, cross-sectional, prospective, and retrospective cohort studies and randomized controlled trials. Eligible studies underwent data extraction and quality assessment using the Newcastle-Ottawa scale. Meta-analyses were conducted using fixed and random effects models in Stata v.18. From 6219 records, 16 studies met the inclusion criteria. Among these, 14 focused on periodontal diseases, while 2 examined dental caries. No studies met the eligibility criteria for tooth wear or orofacial pain. The included studies were predominantly of \"good\" or \"very good\" quality. Meta-analysis indicated that overweight or obese older adults had a significantly higher risk of periodontal disease compared with normal-weight counterparts (pooled odds ratio [OR] = 1.49; 95% confidence interval [CI] 1.13-1.97). The association was stronger in studies conducted in Asia (OR = 2.21; 95% CI 1.28-3.81) and in mixed-sex populations (OR = 1.52; 95% CI 1.02-2.28) compared with male-only samples. The two cross-sectional studies on dental caries yielded inconsistent findings, precluding a meta-analysis for this outcome. This systematic review demonstrates a significant association between overweight/obesity and increased prevalence of periodontal disease in adults aged 55 and older. These findings underscore the need to consider oral health as a key component of general health in this population. The current evidence base is insufficient regarding dental caries, tooth wear, and orofacial pain, highlighting the need for high-quality research in these domains.","PeriodicalId":12730,"journal":{"name":"GeroScience","volume":"43 1","pages":""},"PeriodicalIF":5.6,"publicationDate":"2025-09-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145008717","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The proBNPage reduction (PBAR) trial-results of a randomized, double blind, placebo-controlled, pilot study to fine tune an NT-proBNP-based method to assess the effect of anti-aging treatments.","authors":"Antonio Muscari,Paola Forti,Donatella Magalotti,Mara Brizi,Filomena Piro,Eric Ramazzotti,Loredana Incorvaia,Paolo Maltoni,Daniele Casanova Borca,Eleonora Capelli,Barbara Ciuffi,Paolo Pandolfi,Giovanni Barbara","doi":"10.1007/s11357-025-01827-y","DOIUrl":"https://doi.org/10.1007/s11357-025-01827-y","url":null,"abstract":"NT-proBNP levels increase exponentially with age and are associated with cardiovascular and all-cause mortality. From NT-proBNP concentration a surrogate for biological age (\"proBNPage\") can be obtained. The primary objective of this study was to define a method to design future trials on anti-aging treatments using proBNPage. The secondary objective was the tentative evaluation of 4 potential anti-aging dietary supplements. The trial lasted 2 years and involved 120 healthy subjects aged 71.7 ± 4.6 years divided into 3 groups: A) coenzyme Q10 100 mg bid + selenium 100 mcg, B) resveratrol 350 mg bid + TA-65 100U, C) placebo. ProBNPage was the primary outcome variable. Secondary variables included step test duration, handgrip strength, and self-reported health status. In group B, the study was interrupted at month 5 due to significant LDL-cholesterol increase, probably caused by the high-dose resveratrol. Partly because of dropouts and inadequate treatment intake, groups A and C showed non-significant differences in the primary and secondary variables. Therefore, these groups were considered a single group, in which after 2 years proBNPage increased by 2.5 years (P = 0.01), particularly in subjects over 70 (+ 3.0 years, P = 0.009). It was thus calculated that 126 subjects over 70 could allow the assessment of a 2-year treatment vs. placebo with a power of 80%. This study has developed an NT-proBNP-based method to evaluate future interventions on biological age. The treatments did not induce significant changes in proBNPage. The marked increase in cholesterol in group B suggests that high-dose resveratrol should be avoided.","PeriodicalId":12730,"journal":{"name":"GeroScience","volume":"71 1","pages":""},"PeriodicalIF":5.6,"publicationDate":"2025-09-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145018204","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prediction of cognitive decline and Alzheimer's disease conversion by a plasma biomarker panel in non-demented individuals.","authors":"Min-Koo Park,Jinhyun Ahn,Jin-Muk Lim,Sung-Joo Hwang,Keun-Cheol Kim","doi":"10.1007/s11357-025-01869-2","DOIUrl":"https://doi.org/10.1007/s11357-025-01869-2","url":null,"abstract":"Alzheimer's disease (AD) represents a growing global health burden, underscoring the urgent need for reliable diagnostic and prognostic biomarkers. Although several disease-modifying treatments have recently become available, their effects remain limited, as they primarily delay rather than halt disease progression. Thus, the early and accurate identification of individuals at elevated risk for conversion to AD dementia is crucial to maximize the effectiveness of these therapies and to facilitate timely intervention strategies. Baseline plasma concentrations of amyloid beta 40 (Aβ40), amyloid beta 42 (Aβ42), glial fibrillary acidic protein (GFAP), neurofilament light chain (NFL), and tau phosphorylated at residue 181 and 217 (pTau181, pTau217) were quantified in 233 non-demented participants from the Alzheimer's Disease Neuroimaging Initiative (ADNI) and followed for up to 11 years. Covariates included demographic variables and neuropsychological measures. Longitudinal cognitive trajectories were modelled with linear mixed-effects models (LMM), and the risk of progression to AD dementia was evaluated with logistic regression and Cox proportional-hazards analyses. Longitudinally, higher baseline plasma levels of GFAP, NFL, pTau181, and pTau217 independently predicted steeper cognitive decline. Cross-sectional analyses demonstrated significant associations of pTau217, pTau181, and Aβ42 with baseline memory impairment. A logistic regression model incorporating five plasma biomarkers-Aβ42, GFAP, NFL, pTau181, and pTau217-demonstrated robust predictive accuracy for discrimination of future converters to AD dementia. The addition of demographic variables and a baseline memory score further improved model specificity and positive predictive value. These findings support the utility of a concise plasma biomarker panel comprising Aβ42, GFAP, NFL, pTau181, and pTau217 for predicting both longitudinal cognitive deterioration and conversion to AD dementia. This less-invasive blood-based panel could serve as a practical triage tool to enrich clinical trials and facilitate timely therapeutic interventions with emerging disease-modifying treatments.","PeriodicalId":12730,"journal":{"name":"GeroScience","volume":"24 1","pages":""},"PeriodicalIF":5.6,"publicationDate":"2025-09-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145007086","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Subclinical knee extensor weakness predicts gait and balance impairment in degenerative cervical myelopathy.","authors":"Viprav B Raju,Roxanne Hauer,Mohamed Jalloh,Anjishnu Banerjee,Allison Hyngstrom,Brian D Schmit,Aditya Vedantam","doi":"10.1007/s11357-025-01875-4","DOIUrl":"https://doi.org/10.1007/s11357-025-01875-4","url":null,"abstract":"Degenerative cervical myelopathy (DCM) is a leading cause of non-traumatic spinal cord disorders in older adults. Gait instability and balance dysfunction are common in DCM, even in the absence of clinically evident lower limb weakness. We hypothesized that subclinical weakness, measured through maximal voluntary isometric contractions (MVICs) of the knee extensors and ankle plantar flexors, is associated with impaired gait and balance in individuals with DCM. Pre-surgical DCM participants with symptoms of DCM and MRI evidence of cervical spinal cord compression were prospectively enrolled in this observational study. Knee extensor and ankle plantar flexor MVICs of the self-reported most-affected leg were measured using a Biodex system. Berg Balance Scale (BBS) scores, gait speed and spatiotemporal gait parameters, and the modified Japanese Orthopedic Association score (mJOA) were recorded. Multivariable regression assessed associations between MVICs and gait/balance outcomes, controlling for age and sex. Data from 32 DCM participants (11 females; mean age 59.1 ± 10.7 years) were analyzed. Knee extensor MVICs showed significant positive correlations with gait speed (r = 0.38, p = 0.001), mJOA lower extremity scores (r = 0.41, p = 0.019), and BBS scores (r = 0.44, p = 0.007). These associations remained significant in multivariable linear regression models adjusted for age and sex. Ankle plantar flexor MVICs were not significantly associated with any outcomes (p > 0.05). Knee extensor MVICs reflect subclinical lower extremity weakness and are associated with impaired gait and balance in DCM. MVIC is a promising objective method to quantify motor impairment in DCM.","PeriodicalId":12730,"journal":{"name":"GeroScience","volume":"30 1","pages":""},"PeriodicalIF":5.6,"publicationDate":"2025-09-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145003302","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Distinct factors explain life space mobility below and above the age of 75 years old in older adults.","authors":"Samar Assadi Khalil,Efrat Gil,Roy Tzemah-Shahar,Faisal Azaiza,Rachel Kizony,Maayan Agmon","doi":"10.1007/s11357-025-01873-6","DOIUrl":"https://doi.org/10.1007/s11357-025-01873-6","url":null,"abstract":"Life space mobility (LSM) is important for participation in daily life. It is influenced by individual and environmental factors and tends to decline with age. Although LSM has been studied in older adults, stratification of this population into age subgroups has not been performed, creating a gap in understanding the factors associated with LSM in a more granular manner. This cross-sectional study aimed to identify the factors associated with LSM in community-dwelling older adults below and above the age of 75. Participants aged 65 and older without neurological conditions or dementia were recruited. LSM was assessed using the Life Space Assessment (LSA), mobility with the Timed Up and Go test (TUG), cognition with the Montreal Cognitive Assessment (MoCA), fear of falling with the Activities-specific Balance Confidence scale (ABC), and depression with the Hospital Anxiety and Depression Scale (HADS). Additional self-reported data included employment/volunteering, frequency of leaving the house, functional status, and number of medications. Separate regression models were conducted for each age subgroup. Two-hundred forty-two older adults (28.9% men) were recruited (mean (SD) age 73.7(6.4) years), with 40.9% aged over 75. In the younger subgroup, sex, frequency of leaving the house, TUG, and employment/volunteer status significantly explained 42.8% of the variance in LSM. In the older subgroup, sex, age, ABC, MoCA, and TUG significantly explained 46.9% of the variance in LSM. Distinct factors are associated with LSM in each age subgroup. Accordingly, future interventions should be tailored for each subgroup individually.","PeriodicalId":12730,"journal":{"name":"GeroScience","volume":"49 1","pages":""},"PeriodicalIF":5.6,"publicationDate":"2025-09-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144995715","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The association of thigh myosteatosis with lower cognitive function in older cancer survivors.","authors":"Brendan L McNeish,Brian Kunzer,Sarah G Bell,Caterina Rosano","doi":"10.1007/s11357-025-01857-6","DOIUrl":"https://doi.org/10.1007/s11357-025-01857-6","url":null,"abstract":"INTRODUCTIONCancer is associated with accelerated aging, including changes in muscle composition and cognition. However, the relationship between myosteatosis and cognitive function has not been investigated in older cancer survivors. This study evaluated the association between myosteatosis and cognitive function in this population.METHODSThe sample included 75 cancer survivors (age 76-85; 65% men; 31% Black; 41% prostate cancer; 21% breast cancer) from the Health ABC study who developed cancer within the first five years, completed CT imaging at Year 6, and cognitive testing at Year 10. Thigh intermuscular fat area (myosteatosis) was measured by CT at Year 6. Cognitive function was assessed using the Digit Symbol Substitution Test (DSST) and Modified Mini-Mental Status Exam (3MS) at Years 5 and 10. Multivariable models adjusted for demographics, education, cognitive function, and thigh muscle area at Year 5. Sensitivity analyses adjusted for leg strength, race, dementia risk factors, BMI, abdominal visceral fat, and thigh subcutaneous fat. LASSO regression identified key predictors of DSST and 3MS scores.RESULTSGreater thigh myosteatosis at Year 6 was associated with lower DSST (B =  - 0.212, p < 0.05) and 3MS (B =  - 0.145, p < 0.05) scores at Year 10. Associations remained significant after adjustment for strength, dementia risk, and adiposity. LASSO identified race, education, Year 5 cognition, and myosteatosis as key predictors for DSST as well as thigh muscle area and physical activity for 3MS.DISCUSSIONThigh myosteatosis is independently associated with lower cognitive performance in older cancer survivors and may represent a rehabilitation target to improve cognitive outcomes.","PeriodicalId":12730,"journal":{"name":"GeroScience","volume":"83 1","pages":""},"PeriodicalIF":5.6,"publicationDate":"2025-09-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144995861","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sex differences in brain glucose metabolism in alzheimer's disease: A voxel-based study.","authors":"Matilde Nerattini,Elisabetta Maria Abenavoli,Francesca Caramelli,Giulia Giacomucci,Benedetta Nacmias,Enrico Mossello,Valentina Bessi,Valentina Berti","doi":"10.1007/s11357-025-01872-7","DOIUrl":"https://doi.org/10.1007/s11357-025-01872-7","url":null,"abstract":"A growing body of evidence shows significant sex differences in Alzheimer's Disease (AD) epidemiology, clinical presentation, and pathology burden; however, sex differences in neuroimaging biomarkers remain underexplored, prompting recent calls to action for more targeted research in this field. We analyzed static brain positron emission tomography (PET) imaging with 2-[18F] fluoro-2-deoxy-D-glucose (FDG) from 247 elderly individuals with AD dementia, including 151 women and 96 men. Voxel-based analysis was used to detect reductions in FDG uptake in each sex relative to a publicly shared normative database and to identify sex differences in FDG uptake within the AD cohort. Both sexes exhibited glucose hypometabolism in AD-vulnerable regions, including the parieto-temporal cortex, posterior cingulate, hippocampus, parahippocampal gyrus, and frontal lobes (PFWE ≤ 0.001 in women and ≤ 0.013 in men). Sex differences in regional FDG uptake were observed in both directions, with greater hypometabolism in limbic and frontal regions in women (PFWE ≤ 0.023) and in parietal cortices in men (PFWE ≤ 0.008). The sex-specific distribution of hypometabolism, with more pronounced anterior involvement in women and posterior involvement in men, aligns with known differences in brain reserve and hormone-sensitive regions. This pattern suggests that neurophysiological and neuroendocrine aging may contribute to AD neuropathology in a sex-dependent manner. Recognizing these variations could refine diagnostic approaches and inform the development of sex-specific therapeutic strategies.","PeriodicalId":12730,"journal":{"name":"GeroScience","volume":"33 1","pages":""},"PeriodicalIF":5.6,"publicationDate":"2025-09-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144995719","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Short communication and clear content of geriatric recommendations matter! Evaluation of geriatric recommendation acceptance in patients aged ≥ 85 years hospitalized for cardiac conditions.","authors":"Renee C M A Raijmann,Huiberdina L Koek,Marielle H Emmelot-Vonk,Willem R P Agema,Angele P M Kerckhoffs,Carolina J P W Keijsers","doi":"10.1007/s11357-025-01859-4","DOIUrl":"https://doi.org/10.1007/s11357-025-01859-4","url":null,"abstract":"As patients with cardiovascular disease age, the need for cardiogeriatric care grows. Therefore, we aimed to identify facilitators and hindrances to the implementation of cardiogeriatric care by analysing geriatric recommendations content and acceptance rates. This retrospective cohort study included 100 patients aged > 85 years who received geriatric consultation and were admitted to a cardiology department. A random sample was generated, of which half received proactive geriatric consultation and half received usual care (geriatric consultation upon request). The recommendation content was categorized into geriatric domains (physical, mental, functional, social, and existential), and recommendation uptake was categorized into seven categories (e.g., accepted, declined by patient). Additionally, factors associated with acceptance rates were analysed using univariate logistic regression. The study population (mean age 88, 60% female) received 310 recommendations of which 56% were accepted. The acceptance rate was significantly higher if recommendations belonged to the functional (OR 3.10 (95% CI 1.41-6.82)), social (OR 5.55 (95% CI 2.40-13.00)), and existential domain (OR 6.09 (95% CI 2.62-14.16)) compared to the physical domain. Furthermore, higher acceptance rates were observed if recommendations were communicated verbally instead of electronically (OR 2.16 (95% CI 1.30-6.70)), when a clear tone was used instead of a doubtful one (OR 1.90 (95% CI 1.01-3.56)), and if the recommendation was concisely documented (OR 1.11 (95% CI 1.04-1.20) per average 10 words decrease). In this study, the acceptance rate of geriatric recommendations for older patients with cardiac disease was low. Recommendations regarding the functional, social, and existential domains had the highest acceptance rates. To improve acceptance rates, recommendations should be communicated verbally, documented concisely, and a doubtful tone should be avoided.","PeriodicalId":12730,"journal":{"name":"GeroScience","volume":"23 1","pages":""},"PeriodicalIF":5.6,"publicationDate":"2025-09-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144995817","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}