Ginekologia polska最新文献

{"title":"It's high time to change our management of gestational diabetes.","authors":"Dorota A Bomba-Opon","doi":"10.5603/GP.a2023.0063","DOIUrl":"10.5603/GP.a2023.0063","url":null,"abstract":"","PeriodicalId":12727,"journal":{"name":"Ginekologia polska","volume":"94 6","pages":"427-428"},"PeriodicalIF":1.2,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9803557","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Perinatal and neonatal outcomes of adolescent pregnancies over a 10-year period.","authors":"Bahadir Yazicioglu,&nbsp;Nazan Yurtcu,&nbsp;Huri Guvey,&nbsp;Canan Soyer Caliskan,&nbsp;Samettin Celik,&nbsp;Andrea Tinelli","doi":"10.5603/GP.a2022.0085","DOIUrl":"https://doi.org/10.5603/GP.a2022.0085","url":null,"abstract":"<p><strong>Objectives: </strong>Poor overall neonatal outcomes, small neonatal head circumference, neonatal hypoglycemia, need for Neonatal Intensive Care Unit and late-onset neonatal sepsis are more common in adolescents. The aim of this study is to draw attention to the outcomes of adolescent pregnancies.</p><p><strong>Material and methods: </strong>This retrospective study was conducted in adolescent singleton pregnancies with maternal age < 15 years (n = 20, group 1), 16-19 years (n = 1929, group 2), and 20 years (n = 866, group 3). Age, gravidity, parity, and body mass index (BMI) measurements of mothers; mode of delivery, maternal and neonatal outcomes were evaluated and compared.</p><p><strong>Results: </strong>The rate of preterm birth, postpartum hemorrhage, asymmetrical intra-uterine growth restriction (IUGR, as 3% percentile), macrosomia, and height of newborn of Group 3 was significantly higher. The rate of asymmetrical IUGR (as 10% percentile) was significantly lower in Group 3. The rate of severe preeclampsia and cesarean section was significantly higher in Group 3. The rate of Small for Gestational Age newborn, neonatal hypoglycemia, and late-onset neonatal sepsis was significantly higher in Group 1.</p><p><strong>Conclusions: </strong>Neonatal problems with poor obstetric outcomes are common in adolescent pregnant women, so that a family planning and baby care social trainings are important in achieving good long-term maternal and neonatal outcomes.</p>","PeriodicalId":12727,"journal":{"name":"Ginekologia polska","volume":"94 6","pages":"500-506"},"PeriodicalIF":1.3,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9840538","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Endometrial carcinoma in patients under 40 years of age: insights from the Bulgarian Cancer Registry.","authors":"Angel Yordanov,&nbsp;Stoyan Kostov,&nbsp;Yavor Kornovski,&nbsp;Stanislav Slavchev,&nbsp;Yonka Ivanova,&nbsp;Jean Calleja-Agius,&nbsp;Riccardo Di Fiore,&nbsp;Sherif Suleiman,&nbsp;Andra Piciu,&nbsp;Ihsan Hasan,&nbsp;Mariela Vasileva-Slaveva","doi":"10.5603/GP.a2022.0106","DOIUrl":"https://doi.org/10.5603/GP.a2022.0106","url":null,"abstract":"<p><strong>Objectives: </strong>We aimed to investigate the overall survival (OS) of young women with endometrial cancer (EC) in Bulgaria and the impact of histological type on survival.</p><p><strong>Material and methods: </strong>This is a population-wide retrospective study of patients with EC (≤ 40 years at diagnosis) registered at Bulgarian National Cancer Registry (BNCR) between 1993 and 2020. Patients were re-classified according to the 8th edition of the TNM classification.</p><p><strong>Results: </strong>In total, 30 597 patients were registered and histologically confirmed with malignant tumors of the uterine body. From that, 29 065 of them (95%) had ECs, and the rest had sarcomas. Around 1.64% of all malignant tumors of the uterine body are diagnosed in women under the age of 40. Most of them are diagnosed in the early stage. There was no significant difference in median OS for patients diagnosed before or after 2003. In recent years there was a slight improvement in survival and patients from the last cohort of this study had a 5-year survival rate of 92.5%. Patients with favorable pathology (T1, G1/2) had no lymph node involvement at the time of diagnosis and their 10-year survival rate was 94%.</p><p><strong>Conclusions: </strong>EC in young women is a rare disease. In most cases, patients are diagnosed in early stageT1, G1/2, N0 and their prognosis is excellent. However, the lack of improvement of OS of young patients with EC in the last three decades shows the need for treatment optimization.</p>","PeriodicalId":12727,"journal":{"name":"Ginekologia polska","volume":"94 4","pages":"275-282"},"PeriodicalIF":1.3,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9843503","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Polish women's experience and level of knowledge about fertility and its disorders - a cross-sectional study.","authors":"Weronika Knap-Wielgus, Aleksandra Zygula, Magdalena Malec, Miroslaw Wielgos, Iwona Szymusik","doi":"10.5603/GP.a2023.0047","DOIUrl":"10.5603/GP.a2023.0047","url":null,"abstract":"<p><strong>Objectives: </strong>To assess the experience and knowledge of Polish women up to 50 years of age about fertility and its disorders.</p><p><strong>Material and methods: </strong>A self-composed questionnaire consisting of 44 questions, divided into six sections, was available in social media from January until February 2020. The answers to 13 single-choice questions were analyzed to assess the level of knowledge. Statistical analysis was performed with the use of Statistica 13.0, with p value < 0.05 considered significant.</p><p><strong>Results: </strong>A total of 3,321 correctly filled out questionnaires were obtained. The average result was 8.88 out of 13 single- choice questions regarding the basics of the menstrual cycle and infertility (median 9, standard deviation [SD] 2.21). As many as 65.2% of respondents did not know which days in the cycle were fertile days. The women who had been and/or were pregnant at the time of survey, more often answered better than those, who had never given birth. They had a better mean score of 13 single-choice questions compared to those who had never been pregnant (9.02 vs 8.61, p < 0.001). Respondents who obtained information about infertility from doctors in 86.97% knew that regular intercourse meant 2-3 times per week in comparison to 79.7% of those who were not educated by medical practitioners (p < 0.0001). 69.8% respondents from the first group knew that the test of ovarian reserve existed in comparison to 55.63% of women from the second group (p < 0.0001).</p><p><strong>Conclusions: </strong>The research has shown that the knowledge about fertility and its disorders is not satisfying among Polish women.</p>","PeriodicalId":12727,"journal":{"name":"Ginekologia polska","volume":" ","pages":"605-615"},"PeriodicalIF":1.2,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9808996","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A novel prenatal index predicting the probability of neonatal intensive care in pregnants: amnion progesterone receptor to alfa fetoprotein rate.","authors":"Seyma Banu Arslanca, Tolga Ecemis, Ozgur Sahin, Sevgi Ayhan, Tufan Arslanca, Gamze Sinem Yucel","doi":"10.5603/GP.a2023.0046","DOIUrl":"10.5603/GP.a2023.0046","url":null,"abstract":"<p><strong>Introduction: </strong>Amniocentesis (AC) is the most used interventional procedure for prenatal diagnosis. The study aims to evaluate the pregnancy outcomes undergoing AC and the potential of amnion progesterone receptor (aPR) to alfa fetoprotein (AFP) rate for predicting the probability of neonatal intensive care unit (NICU).</p><p><strong>Material and methods: </strong>This prospective cross-sectional study population consisted of 85 pregnant women who underwent mid-trimester AC. All cases were screened by ultrasound before AC. Maternal venous and amniotic samples were obtained simultaneously to evaluate the serum progesterone (sPRG), aPR, and aAFP and analyzed with patient results.</p><p><strong>Results: </strong>Unlike sPRG and aAFP, aPR showed a positive correlation with NICU and a negative correlation with parity. In linear regression, the aPR-AFP rate showed strong linearity with NICU and parity. In an aPR-AFP rate analysis, we saw a strong predictivity for NICU compared to the other three parameters. It presented 73.4% specificity and 79% sensitivity at 0.0075 cut-off (AUC: 0.78; p = 0.003; 95% CI: 0.608-0.914).</p><p><strong>Conclusions: </strong>Evaluating the PR either alone or in a rational combination with AFP will provide physicians with valuable information about the advanced process of pregnancy and postpartum complications. The physicians might use the aPR-AFP rate to predict NICU potential for pregnancy and need further studies to make more vital predictions on postpartum complications.</p>","PeriodicalId":12727,"journal":{"name":"Ginekologia polska","volume":" ","pages":"727-732"},"PeriodicalIF":1.2,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9808998","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"CoronaVac vaccine does not affect ovarian reserve.","authors":"Ayşe Rabia Şenkaya,&nbsp;Zafer Çil,&nbsp;Ömür Keskin,&nbsp;Mehmet Emin Güneş,&nbsp;Deniz Can Öztekin","doi":"10.5603/GP.a2023.0025","DOIUrl":"https://doi.org/10.5603/GP.a2023.0025","url":null,"abstract":"<p><strong>Objectives: </strong>In this study, our aim is to investigate the effect of CoronaVac vaccine on ovarian reserve in female patients followed up for infertility.</p><p><strong>Material and methods: </strong>Our study is a retrospective study. Forty-six infertile patients who received two doses of CoronaVac vaccine one month apart and had not had a previous Covid 19 infection were included in the study. Anti-müllerian hormone (AMH) and folliculometry of 46 patients one month before CoronaVac vaccine and one month after the second dose of vaccine were compared.</p><p><strong>Results: </strong>There was no statistically significant difference in the change of AMH level and follicle number before and after vaccination (respectively p = 0.366; 0.610).</p><p><strong>Conclusions: </strong>Considering that having a COVID-19 infection has a negative effect on female fertility and causing ovarian damage in recent studies, vaccination is a rational and cost-effective approach to protect ovarian reserve. Knowing that the vaccine does not have a negative effect on fertility may increase the application of the vaccine in women of reproductive age.</p>","PeriodicalId":12727,"journal":{"name":"Ginekologia polska","volume":"94 4","pages":"298-302"},"PeriodicalIF":1.3,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9831524","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"GnRH agonist administration as luteal support on the transfer day of single blastocyst in dual-triggered cycles.","authors":"Ahmet Demir,&nbsp;Can Köse,&nbsp;Ebru Şahin Güleç,&nbsp;Pınar Türkmen,&nbsp;Emrah Töz,&nbsp;Nuri Peker","doi":"10.5603/GP.a2022.0082","DOIUrl":"https://doi.org/10.5603/GP.a2022.0082","url":null,"abstract":"<p><strong>Objectives: </strong>Luteal phase support with gonadotropin-releasing hormone agonist (GnRH-a) has been considered in terms of its potential beneficial effects on in vitro fertilisation (IVF) cycles. In our study, we assessed the effectiveness of single-dose GnRH-a administration in dual-triggered cycles on pregnancy outcomes.</p><p><strong>Material and methods: </strong>Eighty women who underwent intra cytoplasmic sperm injection (ICSI) cycle and had fresh blastocyst transfer were divided into two groups in terms of luteal phase support. The study group (Group A) consisted of patients (n = 40) who received a single-dose GnRH-a injection (0.1 mg of triptorelin acetate) subcutaneously 6 days after oocyte retrieval in addition to 600 mg daily of micronised progesterone, and the control group (Group B) comprised of patients (n = 40) taking 600 mg micronised progesterone daily from the first day after oocyte retrieval. GnRH-a and human chorionic gonadotropin (hCG; dual trigger) were administered to all patients. Comparison of the clinical pregnancy and live birth rates was our main goal.</p><p><strong>Results: </strong>There was no significant difference between the two groups in terms of β-hCG positivity rates, clinical pregnancy rates and live birth rates (p value for beta-hCG = 0.25, clinical pregnancy = 0.80, live birth = 0.45).</p><p><strong>Conclusions: </strong>Our study demonstrated that in dual triggered cycles administration of a single dose of GnRH-a on the transfer day of a single blastocyst in addition to routine luteal phase support with progesterone does not statistically increase implantation, clinical pregnancy or live birth rates.</p>","PeriodicalId":12727,"journal":{"name":"Ginekologia polska","volume":"94 5","pages":"374-388"},"PeriodicalIF":1.3,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10020662","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Elabela levels in pregnancies with intrauterine growth retardation.","authors":"Gulen Yener,&nbsp;Salih Burçin Kavak,&nbsp;Yeliz Gul,&nbsp;Ebru Celik Kavak,&nbsp;Funda Gulcu Bulmus,&nbsp;Cengiz Sanli,&nbsp;Ibrahim Batmaz,&nbsp;Gulay Bulu","doi":"10.5603/GP.a2021.0246","DOIUrl":"https://doi.org/10.5603/GP.a2021.0246","url":null,"abstract":"OBJECTIVES\u0000The aim of our study is to examine maternal serum Elabela levels in pregnancy with intrauterine growth retardation (IUGR). IUGR is one of the most important causes of perinatal mortality and morbidity. IUGR is also related future comorobidities such as diabetes mellitus, hyperlipidemia, hypertension and coronary artery disease.\u0000\u0000\u0000MATERIAL AND METHODS\u0000Fifty pregnancies diagnosed as IUGR (Group 1) and fifty healthy pregnancies (Group 2) enrolled into the study. Obstetric and demographic characteristics of the patients, serum elabela levels, ultrasound parameters, cord pH value and APGAR scores of the newborns were recorded. In the study, which was planned as a prospective case-control study, an independent t test was used for the evaluation of continuous data and the Mann Whitney U test was used for the statistical evaluation of ordinal data. p < 0.05 was considered significant.\u0000\u0000\u0000RESULTS\u0000The mean gestational age of the cases at delivery was 36.35 ± 1.29 in Group 1 and 38.16 ± 0.94 weeks in Group 2 (p < 0.05). Mean serum Elabela levels were 15.05 ± 9.03 in Group 1 and 8.96 ± 4.33 ng/mL in Group 2 (p < 0.0001). Mean newborn weights were 2498.20 ± 465.92 in Group 1 and 3179.44 ± 387.99 gr. in Group 2 (p < 0.0001). Systolic and diastolic blood pressure measurements taken on the day of delivery were higher in Group 1, and diastolic blood pressure was 77.0 ± 9.53 in Group 1 and 72.60 ± 13.37 mmHg in Group 2 (p < 0.05). Bilateral uterine artery Pulsatile Index (PI) and umbilical artery PI value were significantly higher in Group 1 (p < 0.05), and middle cerebral artery PI and cerebroplacental ratio were significantly lower in Group 1 compared to Group 2 (p < 0.05). Although the cord pH value, 1st and 5th minute APGAR scores were lower in Group 1 compared to Group 2, no statistically significant difference was found (p > 0.05).\u0000\u0000\u0000CONLUSIONS\u0000In our study, it was found that serum Elabela levels increased significantly in pregnancies complicated by IUGR compared to the control group.","PeriodicalId":12727,"journal":{"name":"Ginekologia polska","volume":"94 2","pages":"113-118"},"PeriodicalIF":1.3,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9631629","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Polish Society of Gynecologists and Obstetricians' Expert Group Recommendations regarding adolescent pregnancy.","authors":"Agnieszka Drosdzol-Cop,&nbsp;Jakub Staniczek,&nbsp;Dominika Orszulak,&nbsp;Karolina Kowalczyk,&nbsp;Anna Fuchs,&nbsp;Piotr Sieroszewski,&nbsp;Miroslaw Wielgos,&nbsp;Jaroslaw Kalinka,&nbsp;Hubert Huras,&nbsp;Piotr Wegrzyn,&nbsp;Sebastian Kwiatkowski,&nbsp;Mariusz Zimmer,&nbsp;Rafal Stojko","doi":"10.5603/GP.a2023.0038","DOIUrl":"https://doi.org/10.5603/GP.a2023.0038","url":null,"abstract":"","PeriodicalId":12727,"journal":{"name":"Ginekologia polska","volume":"94 3","pages":"258-267"},"PeriodicalIF":1.3,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9644155","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of tissue inhibitor of metalloproteinase-3 (TIMP-3) serum level and its genetic polymorphism with pregnancy outcome of patients undergoing in vitro fertilization and embryo transfer.","authors":"Mahdis Meraji Masouleh Moghaddam,&nbsp;Farhad Mashayekhi,&nbsp;Ziba Zahiri,&nbsp;Akram Eidi","doi":"10.5603/GP.a2022.0060","DOIUrl":"https://doi.org/10.5603/GP.a2022.0060","url":null,"abstract":"<p><strong>Objectives: </strong>Tissue inhibitors of metalloproteinase-3 (TIMP-3) and matrix metalloproteinases (MMPs) play a major role in embryo implantation and placentation. This study aimed to investigate the relationship between TIMP-3 serum level and TIMP-3 genetic polymorphism with pregnancy outcome in patients undergoing in vitro fertilization and embryo transfer (IVF-ET).</p><p><strong>Material and methods: </strong>This project included 100 infertile women who became pregnant after IVF (IVF+) and 100 infertile women who failed to conceive after IVF (IVF-). Genotyping was performed using Restriction Fragments Length Polymorphism Polymerase Chain Reaction (PCR-RFLP), and the serum level was measured by Enzyme-Linked Immunosorbent Assay (ELISA).</p><p><strong>Results: </strong>The frequencies of TT, TC, and CC in the IVF+ group were 41%, 37% and 22%, respectively, while in the IVF- group were 18%, 43% and 39%, respectively. The C and T allele frequencies were 40.5% and 59.5% in the IVF+ group and 60.5% and 39.5% in IVF- group, respectively. The C allele conferred a 2.25-fold increased risk of IVF failure (OR 2.25; 95% CI 1.5-3.35; p = 0.0001). Also, there was a significant increase in TIMP-3 serum levels in the IVF- group (193.29 ± 29.50 ng/mL), which was higher than the IVF+ group (166.74 ± 17.60 ng/mL; p = 0.00002), was demonstrated. It was shown that the TT genotype is associated with decreased TIMP-3 serum levels in IVF- group (CC, CT, and TT, values were 143.19 ± 88.49 ng/mL, 117.55 ± 15.73 ng/mL, 61.17 ± 44.36 ng/mL, respectively).</p><p><strong>Conclusions: </strong>It is concluded that there is a relationship between TIMP-3 gene polymorphism and its serum concentration with IVF-ET outcome. We also suggest that the TT genotype might be involved in IVF-ET outcome.</p>","PeriodicalId":12727,"journal":{"name":"Ginekologia polska","volume":"94 5","pages":"400-406"},"PeriodicalIF":1.3,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9665351","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}