A novel prenatal index predicting the probability of neonatal intensive care in pregnants: amnion progesterone receptor to alfa fetoprotein rate.

IF 16.4 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Accounts of Chemical Research Pub Date : 2023-01-01 Epub Date: 2023-05-10 DOI:10.5603/GP.a2023.0046

Seyma Banu Arslanca, Tolga Ecemis, Ozgur Sahin, Sevgi Ayhan, Tufan Arslanca, Gamze Sinem Yucel

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引用次数: 0

Abstract

Introduction: Amniocentesis (AC) is the most used interventional procedure for prenatal diagnosis. The study aims to evaluate the pregnancy outcomes undergoing AC and the potential of amnion progesterone receptor (aPR) to alfa fetoprotein (AFP) rate for predicting the probability of neonatal intensive care unit (NICU).

Material and methods: This prospective cross-sectional study population consisted of 85 pregnant women who underwent mid-trimester AC. All cases were screened by ultrasound before AC. Maternal venous and amniotic samples were obtained simultaneously to evaluate the serum progesterone (sPRG), aPR, and aAFP and analyzed with patient results.

Results: Unlike sPRG and aAFP, aPR showed a positive correlation with NICU and a negative correlation with parity. In linear regression, the aPR-AFP rate showed strong linearity with NICU and parity. In an aPR-AFP rate analysis, we saw a strong predictivity for NICU compared to the other three parameters. It presented 73.4% specificity and 79% sensitivity at 0.0075 cut-off (AUC: 0.78; p = 0.003; 95% CI: 0.608-0.914).

Conclusions: Evaluating the PR either alone or in a rational combination with AFP will provide physicians with valuable information about the advanced process of pregnancy and postpartum complications. The physicians might use the aPR-AFP rate to predict NICU potential for pregnancy and need further studies to make more vital predictions on postpartum complications.

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预测孕妇接受新生儿重症监护概率的新型产前指数：羊膜孕酮受体与甲胎蛋白比率。

简介羊膜腔穿刺术（AC）是产前诊断中最常用的介入手术。本研究旨在评估羊膜腔穿刺术的妊娠结局，以及羊膜孕酮受体（aPR）与甲胎蛋白（AFP）比值预测新生儿重症监护室（NICU）概率的潜力：这项前瞻性横断面研究的研究对象包括85名接受孕中期剖宫产术的孕妇。所有病例均在剖宫产前进行了超声筛查。同时采集孕妇静脉和羊水样本，评估血清孕酮（sPRG）、aPR和aAFP，并与患者结果进行分析：与 sPRG 和 aAFP 不同，aPR 与新生儿重症监护室呈正相关，与胎次呈负相关。在线性回归中，aPR-AFP 率与新生儿重症监护室和奇偶数呈很强的线性关系。在 aPR-AFP 率分析中，与其他三个参数相比，我们发现其对新生儿重症监护室有很强的预测性。在 0.0075 临界值时，其特异性为 73.4%，灵敏度为 79%（AUC：0.78；P = 0.003；95% CI：0.608-0.914）：结论：单独评估 PR 或将 PR 与甲胎蛋白（AFP）合理结合进行评估，可为医生提供有关妊娠晚期和产后并发症的宝贵信息。医生可以使用 aPR-AFP 比率来预测妊娠的新生儿重症监护室潜力，但还需要进一步的研究来对产后并发症做出更重要的预测。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Accounts of Chemical Research 化学-化学综合

CiteScore

31.40

自引率

1.10%

发文量

312

审稿时长

2 months

期刊介绍： Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.