{"title":"Clinicopathologic features and prognostic impact of late recurrence after gastrectomy for gastric cancer.","authors":"Kensuke Kudou, Tomoyuki Irino, Motonari Ri, Masaru Hayami, Souya Nunobe","doi":"10.1007/s10120-026-01725-y","DOIUrl":"10.1007/s10120-026-01725-y","url":null,"abstract":"","PeriodicalId":12684,"journal":{"name":"Gastric Cancer","volume":" ","pages":"650-657"},"PeriodicalIF":5.1,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147343422","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Gastric CancerPub Date : 2026-05-01Epub Date: 2026-03-06DOI: 10.1007/s10120-026-01729-8
Youjin Kim, Seunghyun Lee, Jongin Lee, Min Young Park, Jeehee Min, Xiaoxue Ma, Maiko Hajime Sumikawa, Jin-Ha Yoon, Wanhyung Lee
{"title":"A two-sample Mendelian randomization study of the causal relationship between respiratory diseases, gastric cancer risk, and Helicobacter pylori infection.","authors":"Youjin Kim, Seunghyun Lee, Jongin Lee, Min Young Park, Jeehee Min, Xiaoxue Ma, Maiko Hajime Sumikawa, Jin-Ha Yoon, Wanhyung Lee","doi":"10.1007/s10120-026-01729-8","DOIUrl":"10.1007/s10120-026-01729-8","url":null,"abstract":"","PeriodicalId":12684,"journal":{"name":"Gastric Cancer","volume":" ","pages":"519-526"},"PeriodicalIF":5.1,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13124861/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147364986","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Limited lymphadenectomy for elderly patient with gastric cancer: a systematic review and meta-analysis.","authors":"Yuichiro Miki, Tsubasa Bito, Rie Makuuchi, Kenichi Ishizu, Ayumi Shintani, Masanori Terashima","doi":"10.1007/s10120-026-01719-w","DOIUrl":"10.1007/s10120-026-01719-w","url":null,"abstract":"<p><strong>Background: </strong>With aging populations, elderly gastric cancer (GC) patients are increasing. D2 lymphadenectomy is widely accepted for advanced GC, but its efficacy and safety in elderly patients are still debated. To guide surgical decisions, we conducted a systematic review and meta-analysis evaluating optimal lymphadenectomy extent in elderly patients.</p><p><strong>Methods: </strong>A systematic review was performed in accordance with the preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) extension statement for reporting systematic reviews. Meta-analyses were performed regarding (i) total postoperative complications, (ii) pancreatic fistula, (iii) abdominal abscess, (iv) postoperative hospital stay, and (v) overall survival by using R software.</p><p><strong>Results: </strong>Seven retrospective studies met eligibility criteria, including three with propensity score matching. Meta-analysis showed that complication rates (any grade) were similar, while severe complications (grade ≥ 3) tended to be lower with limited lymphadenectomy. Pancreatic fistula rates showed no significant difference, but limited lymphadenectomy was significantly associated with reduced abdominal abscess incidence (RR: 0.15, p = 0.013). Postoperative hospital stay did not differ significantly between the groups. Furthermore, no significant difference in overall survival was observed between the groups (HR: 0.94, p = 0.834).</p><p><strong>Conclusion: </strong>Limited lymphadenectomy may be a reasonable surgical option for elderly GC patients, as it reduces the risk of abdominal abscess without compromising long-term survival. These findings support a more tailored surgical approach based on patient age and risk profile.</p>","PeriodicalId":12684,"journal":{"name":"Gastric Cancer","volume":" ","pages":"485-493"},"PeriodicalIF":5.1,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147511540","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Targeting the OXNAD1-PTGS2 axis with resveratrol overcomes ferroptosis Inhibition and reverses 5-FU resistance in gastric cancer.","authors":"Jinzhou Wang, Bishuang Xu, Xiaohan Lin, Biyu Chen, Xiaoyan Liu, Wei Wu","doi":"10.1007/s10120-026-01718-x","DOIUrl":"10.1007/s10120-026-01718-x","url":null,"abstract":"<p><strong>Background: </strong>5-Fluorouracil (5-FU) remains a cornerstone of first-line chemotherapy for gastric cancer, yet the emergence of resistance severely compromises its clinical efficacy. Although ferroptosis suppression has been recognized as a pivotal mechanism of chemoresistance, the mitochondrial regulatory processes involved remain poorly understood.</p><p><strong>Methods: </strong>We integrated clinical specimen analysis, in vitro and in vivo functional assays, multi-omics profiling, and molecular docking to delineate the role of the mitochondrial oxidoreductase OXNAD1 in mediating 5-FU resistance in gastric cancer, and to assess the therapeutic potential of the natural polyphenol resveratrol as a chemosensitizing agent.</p><p><strong>Results: </strong>OXNAD1 was found to be significantly overexpressed in gastric cancer tissues and cell lines, correlating with unfavorable prognosis and enhanced 5-FU resistance. Mechanistically, OXNAD1 directly bound to and suppressed the ferroptosis driver PTGS2, thereby attenuating lipid peroxidation and mitochondrial damage, ultimately restraining ferroptosis and promoting drug resistance. Notably, resveratrol disrupted the OXNAD1-PTGS2 interaction by directly binding OXNAD1, reinstating ferroptotic activity, markedly enhancing the cytotoxic effect of 5-FU in resistant cells, and potentiating the antitumor efficacy of 5-FU in xenograft models.</p><p><strong>Conclusion: </strong>The OXNAD1-PTGS2 axis constitutes a critical metabolic-cell death cross-regulatory pathway underlying 5-FU resistance in gastric cancer. Targeting this axis with resveratrol provides a promising combinatorial strategy to overcome chemoresistance.</p>","PeriodicalId":12684,"journal":{"name":"Gastric Cancer","volume":" ","pages":"561-577"},"PeriodicalIF":5.1,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147456677","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Gastric CancerPub Date : 2026-05-01Epub Date: 2026-03-07DOI: 10.1007/s10120-026-01723-0
Frank G Lee, Jack W Sample, Chun Fan, Robert A Vierkant, Sara K Daniel, Steven Bowers, Nabil Wasif, Mark J Truty, Michael L Kendrick, Cornelius A Thiels, Travis E Grotz
{"title":"Long-term quality of life, financial toxicity, and decision regret following therapeutic and prophylactic gastrectomy for cancer.","authors":"Frank G Lee, Jack W Sample, Chun Fan, Robert A Vierkant, Sara K Daniel, Steven Bowers, Nabil Wasif, Mark J Truty, Michael L Kendrick, Cornelius A Thiels, Travis E Grotz","doi":"10.1007/s10120-026-01723-0","DOIUrl":"10.1007/s10120-026-01723-0","url":null,"abstract":"","PeriodicalId":12684,"journal":{"name":"Gastric Cancer","volume":" ","pages":"635-649"},"PeriodicalIF":5.1,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147372866","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Gastric CancerPub Date : 2026-05-01Epub Date: 2026-03-09DOI: 10.1007/s10120-026-01728-9
Yuntong Wang, Dong-Woo Choi, Sangwon Lee, Jialin Mao, Art Sedrakyan, Xiang Shu, Kui Son Choi, Heejung Chae, Eunji Choi
{"title":"Racial/ethnic and geographic differences in second primary cancers in stomach cancer survivors: a comparative study of U.S. and South Korea.","authors":"Yuntong Wang, Dong-Woo Choi, Sangwon Lee, Jialin Mao, Art Sedrakyan, Xiang Shu, Kui Son Choi, Heejung Chae, Eunji Choi","doi":"10.1007/s10120-026-01728-9","DOIUrl":"10.1007/s10120-026-01728-9","url":null,"abstract":"<p><strong>Background: </strong>Stomach cancer remains the fifth leading cause of cancer death, with racial/ethnic and geographic differences. As survival improves, these survivors face elevated risks of second primary cancers (SPCs). We evaluated SPC risk and post-SPC survival by race/ethnicity and between the U.S. and South Korea.</p><p><strong>Methods: </strong>We analyzed patients with stage I-III stomach cancer (2012-2020) from the U.S. SEER-17 and Korea Cancer Public-Library Database. SPCs were defined as non-gastric cancers diagnosed > 1 year post initial diagnosis. Cumulative SPC incidence was estimated using Aalen-Johansen method to account for competing death. Cox regression assessed survival impact of SPC development.</p><p><strong>Results: </strong>Among 19,595 U.S. and 204,240 Korean patients, 1,050 and 6,908 developed SPCs, respectively. In the U.S., 5-year SPC incidence was highest in Black (7.4% [6.1-8.6]) and lowest in Pacific Islanders (4.5% [2.3-6.7]). Notable heterogeneity in SPC incidence was observed across Asian subgroups, with Korean Americans showing the highest (6.9% [4.7-9.1]) and Filipinos the lowest (4.4% [1.9-7.2]). In contrast, Korean survivors in South Korea had the lowest SPC incidence (3.8% [3.7-3.9]). SPC development was associated with higher mortality (HR = 2.22 [1.96-2.52]), with a stronger effect in Asians (HR = 3.12) than Whites (HR = 1.96; interaction P < 0.1). Among Asian subgroups, SPC development was associated with the highest mortality in Vietnamese (HR = 13.6) and the lowest in Filipino survivors (HR = 1.54; interaction P < 0.01). Among Korean survivors in South Korea, SPC development conferred a modest increase in mortality risk (HR = 1.68 [1.61-1.75]).</p><p><strong>Conclusions: </strong>SPC risk and outcomes in stomach cancer survivors vary by race/ethnicity and country, particularly within Asian subgroups.</p>","PeriodicalId":12684,"journal":{"name":"Gastric Cancer","volume":" ","pages":"506-518"},"PeriodicalIF":5.1,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13124850/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147390023","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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