Clinicopathological significance of JAK2, STAT3, and STAT4 expression in patients with gastric solid-type poorly differentiated adenocarcinoma: a retrospective study.

IF 5.1 1区医学 Q1 GASTROENTEROLOGY & HEPATOLOGY

Gastric Cancer Pub Date : 2025-05-01 Epub Date: 2025-02-17 DOI:10.1007/s10120-025-01589-8

Shinya Umekita, Daisuke Kiyozawa, Hitoshi Honma, Kenichi Kohashi, Yoshiaki Taniguchi, Shinichiro Kawatoko, Taisuke Sasaki, Eikichi Ihara, Eiji Oki, Masafumi Nakamura, Yoshihiro Ogawa, Yoshinao Oda

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引用次数: 0

Abstract

Background: The role of janus kinase (JAK)/signal transducer and activator of transcription (STAT) signaling remains unclear in gastric solid-type poorly differentiated adenocarcinoma. The present study investigates the clinicopathological significance of JAK2, STAT3, and STAT4 expression in solid-type poorly differentiated adenocarcinoma.

Methods: We retrospectively enrolled 102 participants with primary solid-type poorly differentiated adenocarcinoma. We categorized participants according to deficient or proficient mismatch repair status (46 and 56 participants, respectively). Expression of phosphorylated JAK2 (pJAK2), phosphorylated STAT3 (pSTAT3), and STAT4 were analyzed via immunohistochemistry. We analyzed differences in protein expression in relation to mismatch repair status, and associations of high/low protein expression with clinicopathological characteristics and prognoses.

Results: Deficient mismatch repair was found to be associated with high pJAK2 (p = 0.038) and STAT4 (p = 0.023) expression in contrast to proficient mismatch repair. Log-rank analysis revealed high pSTAT3 and low STAT4 expression to be significantly correlated with reduced overall survival (p = 0.001). Multivariate analysis revealed high pSTAT3 and low STAT4 expression to be independent indicators of unfavorable prognosis (hazard ratio = 2.751, p = 0.030), as was proficient mismatch repair status (hazard ratio = 3.819, p = 0.012).

Conclusions: High expression of pJAK2 and STAT4 is more frequent in deficient compared with proficient mismatch repair in solid-type poorly differentiated adenocarcinoma. High pSTAT3 and low STAT4 expression could be a useful prognostic indicator in solid-type poorly differentiated adenocarcinoma.

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胃固体型低分化腺癌患者JAK2、STAT3和STAT4表达的临床病理意义：一项回顾性研究

背景：janus激酶(JAK)/信号转导和转录激活因子（STAT）信号在胃固体型低分化腺癌中的作用尚不清楚。本研究探讨JAK2、STAT3和STAT4在固体型低分化腺癌中的表达及其临床病理意义。方法：我们回顾性纳入102例原发性固体型低分化腺癌患者。我们根据缺陷或熟练错配修复状态对参与者进行分类（分别为46和56名参与者）。通过免疫组化分析磷酸化JAK2 （pJAK2）、磷酸化STAT3 （pSTAT3）和STAT4的表达。我们分析了与错配修复状态相关的蛋白表达差异，以及高/低蛋白表达与临床病理特征和预后的关系。结果：错配修复缺陷与高pJAK2 （p = 0.038）和STAT4 （p = 0.023）表达相关。Log-rank分析显示pSTAT3高表达和STAT4低表达与总生存率降低显著相关（p = 0.001）。多因素分析显示，pSTAT3高表达和STAT4低表达是预后不良的独立指标（风险比= 2.751,p = 0.030），错配修复状态熟练也是预后不良的独立指标（风险比= 3.819,p = 0.012）。结论：在固体型低分化腺癌中，pJAK2和STAT4的高表达在缺陷中比在完全错配修复中更常见。高表达的pSTAT3和低表达的STAT4可能是固体型低分化腺癌的一个有用的预后指标。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Gastric Cancer 医学-胃肠肝病学

CiteScore

14.70

自引率

2.70%

发文量

审稿时长

6-12 weeks

期刊介绍： Gastric Cancer is an esteemed global forum that focuses on various aspects of gastric cancer research, treatment, and biology worldwide. The journal promotes a diverse range of content, including original articles, case reports, short communications, and technical notes. It also welcomes Letters to the Editor discussing published articles or sharing viewpoints on gastric cancer topics. Review articles are predominantly sought after by the Editor, ensuring comprehensive coverage of the field. With a dedicated and knowledgeable editorial team, the journal is committed to providing exceptional support and ensuring high levels of author satisfaction. In fact, over 90% of published authors have expressed their intent to publish again in our esteemed journal.