Differential impact of frailty on surgical and non-surgical site complications in patients with gastric cancer undergoing gastrectomy.

IF 6 1区医学 Q1 GASTROENTEROLOGY & HEPATOLOGY

Gastric Cancer Pub Date : 2025-05-01 Epub Date: 2025-01-28 DOI:10.1007/s10120-025-01590-1

Katsunobu Sakurai, Naoshi Kubo, Tatsuro Tamura, Tsuyoshi Hasegawa, Yutaka Tamamori, Junya Nishimura, Yasuhito Iseki, Takafumi Nishii, Toru Inoue, Masakazu Yashiro, Yukio Nishiguchi, Tsubasa Bito, Kiyoshi Maeda

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引用次数: 0

Abstract

Background: The aim of this study was to determine the differential impact of frailty on surgical site complications (SSCs) and non-surgical site complications (non-SSCs) in gastric cancer (GC) patients undergoing gastrectomy.

Methods: In this study, frailty was assessed preoperatively using a frailty index (FI) in 395 patients scheduled for gastrectomy for GC between January 2016 and December 2023. Patients were divided into two groups (high FI vs. low FI) to examine the impact of frailty on SSC and non-SSC.

Results: Overall complication and non-SSC rates were significantly higher in the high FI group, but the two groups had similar rates of SSC. In multivariate analysis, high FI, high BMI, and male were independent risk factors for non-SSC. The incidence of non-SSC was 0% in patients with no applicable risk factors, 3.6% in patients with one applicable risk factor, 13.0% in patients with two applicable risk factors, and 37.1% in patients with all three risk factors (Cochran-Armitage trend test, p < 0.001). The area under the curve (AUC) of the risk prediction model using these three variables to predict non-SSC was 0.760.

Conclusions: High FI was an independent risk factor for non-SSC in patients undergoing gastrectomy for GC. Our developed non-SSC risk model combining FI, BMI, and sex effectively identifies individuals at increased risk for non-SSC in GC patients.

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虚弱对胃癌行胃切除术患者手术和非手术部位并发症的不同影响。

背景：本研究的目的是确定虚弱对胃癌（GC）切除术患者手术部位并发症（SSCs）和非手术部位并发症（non-SSCs）的差异影响。方法：在本研究中，对2016年1月至2023年12月期间395例因胃癌而计划行胃切除术的患者进行术前虚弱度评估，采用虚弱指数（FI）。患者被分为两组（高FI和低FI），以检查虚弱对SSC和非SSC的影响。结果：高FI组总并发症及非SSC发生率明显高于高FI组，但两组SSC发生率相近。在多因素分析中，高FI、高BMI和男性是非ssc的独立危险因素。无适用危险因素的患者非ssc发生率为0%，有一种适用危险因素的患者为3.6%，有两种适用危险因素的患者为13.0%，有三种危险因素的患者为37.1% （Cochran-Armitage趋势检验，p）。结论：高FI是胃癌切除术患者非ssc的独立危险因素。我们开发的非ssc风险模型结合FI、BMI和性别有效地识别了GC患者中非ssc风险增加的个体。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Gastric Cancer 医学-胃肠肝病学

CiteScore

14.70

自引率

2.70%

发文量

审稿时长

6-12 weeks

期刊介绍： Gastric Cancer is an esteemed global forum that focuses on various aspects of gastric cancer research, treatment, and biology worldwide. The journal promotes a diverse range of content, including original articles, case reports, short communications, and technical notes. It also welcomes Letters to the Editor discussing published articles or sharing viewpoints on gastric cancer topics. Review articles are predominantly sought after by the Editor, ensuring comprehensive coverage of the field. With a dedicated and knowledgeable editorial team, the journal is committed to providing exceptional support and ensuring high levels of author satisfaction. In fact, over 90% of published authors have expressed their intent to publish again in our esteemed journal.