Frontiers in Neuroscience最新文献

{"title":"Ferroptosis-associated signaling pathways and therapeutic approaches in depression.","authors":"Xuyang Feng, Wenyu Zhang, Xiaoxi Liu, Qiuxuan Wang, Xiao Dang, Jingxian Han, Xuezhu Zhang","doi":"10.3389/fnins.2025.1559597","DOIUrl":"10.3389/fnins.2025.1559597","url":null,"abstract":"<p><p>Ferroptosis, a newly identified form of cell death, is characterized by excessive iron accumulation and lipid peroxidation. Studies indicate a strong association between ferroptosis and depression; however, the precise signaling pathways and underlying molecular mechanisms remain unclear. This review summarizes the role of ferroptosis in depression and its associated signaling pathways. Additionally, therapeutic approaches for depression based on ferroptosis theory are reviewed, providing novel targets for the prevention and treatment of depression and laying a foundation for future research on the relationship between ferroptosis and depression.</p>","PeriodicalId":12639,"journal":{"name":"Frontiers in Neuroscience","volume":"19 ","pages":"1559597"},"PeriodicalIF":3.2,"publicationDate":"2025-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11961976/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143772023","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Automated detection of cervical spondylotic myelopathy: harnessing the power of natural language processing.","authors":"GuanRui Ren, PeiYang Wang, ZhiWei Wang, ZhiYang Xie, Lei Liu, YunTao Wang, XiaoTao Wu","doi":"10.3389/fnins.2025.1421792","DOIUrl":"10.3389/fnins.2025.1421792","url":null,"abstract":"<p><strong>Background: </strong>The objective of this study was to develop machine learning (ML) algorithms utilizing natural language processing (NLP) techniques for the automated detection of cervical spondylotic myelopathy (CSM) through the analysis of positive symptoms in free-text admission notes. This approach enables the timely identification and management of CSM, leading to optimal outcomes.</p><p><strong>Methods: </strong>The dataset consisted of 1,214 patients diagnosed with cervical diseases as their primary condition between June 2013 and June 2020. A random ratio of 7:3 was employed to partition the dataset into training and testing subsets. Two machine learning models, Extreme Gradient Boosting (XGBoost) and Bidirectional Long Short Term Memory Network (LSTM), were developed. The performance of these models was assessed using various metrics, including the Receiver Operating Characteristic (ROC) curve, Area Under the Curve (AUC), accuracy, precision, recall, and F1 score.</p><p><strong>Results: </strong>In the testing set, the LSTM achieved an AUC of 0.9025, an accuracy of 0.8740, a recall of 0.9560, an F1 score of 0.9122, and a precision of 0.8723. The LSTM model demonstrated superior clinical applicability compared to the XGBoost model, as evidenced by calibration curves and decision curve analysis.</p><p><strong>Conclusions: </strong>The timely identification of suspected CSM allows for prompt confirmation of diagnosis and treatment. The utilization of NLP algorithm demonstrated excellent discriminatory capabilities in identifying CSM based on positive symptoms in free-text admission notes complaint data. This study showcases the potential of a pre-diagnosis system in the field of spine.</p>","PeriodicalId":12639,"journal":{"name":"Frontiers in Neuroscience","volume":"19 ","pages":"1421792"},"PeriodicalIF":3.2,"publicationDate":"2025-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11962790/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143772019","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Visual nudging of navigation strategies improves frequency discrimination during auditory-guided locomotion.","authors":"Annalenia Malzacher, Tobias Hilbig, Michael Pecka, Dardo N Ferreiro","doi":"10.3389/fnins.2025.1535759","DOIUrl":"10.3389/fnins.2025.1535759","url":null,"abstract":"<p><p>Perception in natural environments requires integrating multisensory inputs while navigating our surroundings. During locomotion, sensory cues such as vision and audition change coherently, providing crucial environmental information. This integration may affect perceptual thresholds due to sensory interference. Vision often dominates in multimodal contexts, overshadowing auditory information and potentially degrading audition. While traditional laboratory experiments offer controlled insights into sensory integration, they often fail to replicate the dynamic, multisensory interactions of real-world behavior. We used a naturalistic paradigm in which participants navigate an arena searching for a target guided by position-dependent auditory cues. Previous findings showed that frequency discrimination thresholds during self-motion matched those in stationary paradigms, even though participants often relied on visually dominated navigation instead of auditory feedback. This suggested that vision might affect auditory perceptual thresholds in naturalistic settings. Here, we manipulated visual input to examine its effect on frequency discrimination and search strategy selection. By degrading visual input, we nudged participants' attention toward audition, leveraging subtle sensory adjustments to promote adaptive use of auditory cues without restricting their freedom of choice. Thus, this approach explores how attentional shifts influence multisensory integration during self-motion. Our results show that frequency discrimination thresholds improved by restricting visual input, suggesting that reducing visual interference can increase auditory sensitivity. This is consistent with adaptive behavioral theories, suggesting that individuals can dynamically adjust their perceptual strategies to leverage the most reliable sensory inputs. These findings contribute to a better understanding of multisensory integration, highlighting the flexibility of sensory systems in complex environments.</p>","PeriodicalId":12639,"journal":{"name":"Frontiers in Neuroscience","volume":"19 ","pages":"1535759"},"PeriodicalIF":3.2,"publicationDate":"2025-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11963732/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143772037","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"How do neurons live long and healthy? The mechanism of neuronal genome integrity.","authors":"Dai Ihara, Nur Rasyiqin Rasli, Yu Katsuyama","doi":"10.3389/fnins.2025.1552790","DOIUrl":"10.3389/fnins.2025.1552790","url":null,"abstract":"<p><p>Genome DNA of neurons in the brain is unstable, and mutations caused by inaccurate repair can lead to neurodevelopmental and neurodegenerative disorders. Damage to the neuronal genome is induced both exogenously and endogenously. Rapid cell proliferation of neural stem cells during embryonic brain development can lead to errors in genome duplication. Electrical excitations and drastic changes in gene expression in functional neurons cause risks of damaging genomic DNA. The precise repair of DNA damages caused by events making genomic DNA unstable maintains neuronal functions. The maintenance of the DNA sequence and structure of the genome is known as genomic integrity. Molecular mechanisms that maintain genomic integrity are critical for healthy neuronal function. In this review, we describe recent progress in understanding the genome integrity in functional neurons referring to their disruptions reported in neurological diseases.</p>","PeriodicalId":12639,"journal":{"name":"Frontiers in Neuroscience","volume":"19 ","pages":"1552790"},"PeriodicalIF":3.2,"publicationDate":"2025-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11961891/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143771984","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Editorial: Innovative approaches to catalyze preclinical and clinical research on amyotrophic lateral sclerosis (ALS) and related disorders.","authors":"Thibaut Burg, Laura Tzeplaeff, Raphaelle Cassel, Paul Lingor","doi":"10.3389/fnins.2025.1582539","DOIUrl":"10.3389/fnins.2025.1582539","url":null,"abstract":"","PeriodicalId":12639,"journal":{"name":"Frontiers in Neuroscience","volume":"19 ","pages":"1582539"},"PeriodicalIF":3.2,"publicationDate":"2025-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11960142/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143763681","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect and mechanism of GLP-1 on cognitive function in diabetes mellitus.","authors":"Xiaoke Dou, Lei Zhao, Jing Li, Yaqiu Jiang","doi":"10.3389/fnins.2025.1537898","DOIUrl":"10.3389/fnins.2025.1537898","url":null,"abstract":"<p><strong>Background: </strong>Diabetes mellitus (DM) is a metabolic disorder associated with cognitive impairment. Glucagon-like peptide-1 (GLP-1) and its receptor (GLP-1R) have shown neuroprotective effects.</p><p><strong>Scope of review: </strong>This review explores the impact of DM on cognitive function. Diabetes-related cognitive impairment is divided into three stages: diabetes-associated cognitive decrements, mild cognitive impairment (MCI), and dementia. GLP-1R agonists (GLP-1RAs) have many functions, such as neuroprotection, inhibiting infection, and metabolic regulation, and show good application prospects in improving cognitive function. The mechanisms of GLP-1RAs neuroprotection may be interconnected, warranting further investigation. Understanding these mechanisms could lead to targeted treatments for diabetes-related cognitive dysfunction.</p><p><strong>Major conclusions: </strong>Therefore, this paper reviewed the regulatory effects of GLP-1 on cognitive dysfunction and its possible mechanism. Further research is required to fully explore the potential of GLP-1 and its analogs in this context.</p>","PeriodicalId":12639,"journal":{"name":"Frontiers in Neuroscience","volume":"19 ","pages":"1537898"},"PeriodicalIF":3.2,"publicationDate":"2025-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11959055/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143763684","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Editorial: Understanding and managing diabetic neuropathy: current perspectives and future directions.","authors":"Paramita Basu, Pranav Prasoon, Keiichiro Susuki","doi":"10.3389/fnins.2025.1582123","DOIUrl":"10.3389/fnins.2025.1582123","url":null,"abstract":"","PeriodicalId":12639,"journal":{"name":"Frontiers in Neuroscience","volume":"19 ","pages":"1582123"},"PeriodicalIF":3.2,"publicationDate":"2025-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11960141/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143763682","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Research progress in modulating the auditory system by the cochlear circadian clock system in response to noise exposure.","authors":"Xiaoqiong Song, Mengzhu Cheng, Cui Gu, Fenghan Wang, Kefeng Ma, Chunping Wang, Xiaojun She, Bo Cui","doi":"10.3389/fnins.2025.1507363","DOIUrl":"10.3389/fnins.2025.1507363","url":null,"abstract":"<p><p>The circadian clock is an endogenous system evolved to adapt to environmental changes. Recent studies confirmed that the cochlea exhibits circadian oscillations regulating auditory function. These oscillations are linked to brain-derived neurotrophic factor and glucocorticoid levels. Circadian rhythms influence cochlear sensitivity to noise by regulating the secretion of brain-derived neurotrophic factors and glucocorticoids. This study explores the regulatory mechanism of the circadian clock system, its impact on the auditory system, and its potential role in noise-induced hearing loss. Understanding the regulatory mechanisms of circadian rhythms in auditory function will provide new ideas for developing treatments for noise-induced hearing loss.</p>","PeriodicalId":12639,"journal":{"name":"Frontiers in Neuroscience","volume":"19 ","pages":"1507363"},"PeriodicalIF":3.2,"publicationDate":"2025-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11958988/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143763687","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Multiple voxel pattern analysis shows associations between chronic fatigue syndrome and cortical atrophy.","authors":"Kang Wu, Yihuai Zou, Yuanyuan Li, Xiaojie Hu, Yahui Wang, Tianzhu Chen, Yuhang Chen, Kuangshi Li","doi":"10.3389/fnins.2025.1535088","DOIUrl":"10.3389/fnins.2025.1535088","url":null,"abstract":"<p><p>Chronic Fatigue Syndrome (CFS) is a disease characterized by unexplained fatigue and impaired cognition for more than 6 months. Recent studies have reported declines in large-scale brain networks' functional connections among patients with CFS, and these declines correlated with the patients' symptom severity. However, these reported networks are inconsistent. Brain structure serves as the essential architecture supporting brain functional fluctuations. Investigating structural alterations could provide insights into functional changes in different brain areas and facilitate the clinical diagnosis of CFS. In this study, we recruited 37 patients with CFS and 34 healthy controls to collect their clinical assessments and structural magnetic resonance imaging data. Multiple Voxel Pattern Analysis (MVPA) was employed to recognize chronic fatigue-related brain areas, and cortical thickness was compared between the two groups. By constructing a predictive MVPA classifier with 70% balanced accuracy, we identified five relevant brain areas, including the paracentral cortex, precentral cortex, central cortex, intraparietal cortex, and superior temporal cortex. Subsequently, the results showed that the thickness of these areas had associations with fatigue severity, healthy life status, and pain levels among our subjects. Furthermore, compared to healthy controls, the thickness reduction was observed in patients with CFS. In summary, our study revealed a pathological chronic fatigue pattern for understanding CFS and suggested associations between cortical atrophy and CFS, with the aim of highlighting potential impacts of chronic fatigue. The trial was registered in the Chinese Clinical Trial Registry (ChiCTR2000032577).</p>","PeriodicalId":12639,"journal":{"name":"Frontiers in Neuroscience","volume":"19 ","pages":"1535088"},"PeriodicalIF":3.2,"publicationDate":"2025-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11955708/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143752349","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"High efficacy therapy to prevent the formation of meningeal tertiary lymphoid organs after CXCL13 index screening in early multiple sclerosis.","authors":"Ana C Londoño, Carlos A Mora","doi":"10.3389/fnins.2025.1558810","DOIUrl":"10.3389/fnins.2025.1558810","url":null,"abstract":"<p><p>Postmortem studies have shown the presence of subpial inflammation with tertiary lymphoid organs (TLO) in the meninges of patients with progressive multiple sclerosis, playing an important role in the pathophysiology of the disease. The chemokine (C-X-C motif) ligand 13 (CXCL13) induces the formation of these lymphoid organs, thus promoting activity of disease. The progression to disability in multiple sclerosis has been reduced, thanks to the effect of disease modifying therapy. However, despite advances in the treatment of disease with immunomodulatory agents, we still lack specific laboratory biomarkers that could indicate the state of activity of disease, either at time of diagnosis or when escalation therapy seems to be mandatory. In patients with multiple sclerosis, MRI studies have not demonstrated the presence of TLO in the CNS, so far. The determination of the CXCL13 index (ICXCL 13), in clinical specimens, could become a reliable biomarker for the verification of the presence and activity of the TLO, thus contributing to improving therapy outcome, with high efficacy therapy, in the clinical setting.</p>","PeriodicalId":12639,"journal":{"name":"Frontiers in Neuroscience","volume":"19 ","pages":"1558810"},"PeriodicalIF":3.2,"publicationDate":"2025-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11955623/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143752348","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}