Frontiers in Neuroscience最新文献

{"title":"Human melanopsin (OPN4) gene polymorphisms: a systematic review.","authors":"Kevin R Lucio-Enríquez, Mariazel Rubio-Valles, Arnulfo Ramos-Jiménez, Jorge A Pérez-León","doi":"10.3389/fnins.2025.1581266","DOIUrl":"10.3389/fnins.2025.1581266","url":null,"abstract":"<p><p>The melanopsin (OPN4) gene is crucial in visual and non-visual processes. Certain single-nucleotide polymorphisms (SNPs) of this gene have been linked to altered light sensitivity, photoentrainment, sleep disorders, and metabolic problems, which suggests a systemic effect of light exposure. The aim of this systematic review is to explore the current literature regarding the OPN4 gene and its SNPs, along with their associations with health-related problems. The literature search was conducted in PubMed and ScienceDirect databases using the following key terms: (\"Melanopsin\" OR \"OPN4\" OR \"Opsin 4\") AND (\"Polymorphism\" OR \"SNP\" OR \"Variant\"). The publications were from January 1998 to February 2025. We identified 763 studies, and after screening titles, abstracts, full texts, and the inclusion and exclusion criteria, nine studies were included in the review. The review was conducted by two independent reviewers following the PRISMA guidelines. Our review revealed that some SNPs of the OPN4 gene, such as P10L, I394T, and R168C, are associated with affective states, changes in chronotype, and sleep disorders: P10L variant has been associated to seasonal affective disorder (SAD), chronotype, and chronic insomnia; I394T variant has been linked to the pupillary light response (PLR) and sleep/wake timing, while R168C variant has been associated with delayed sleep-wake phase disorder (DSWPD). Currently, the remaining SNPs have no reported associations, and the existing literature does not describe any specific molecular mechanisms through which these variants could modulate or alter OPN4 function. Future research should aim to explore these identified SNPs with alternative associations related to OPN4 functions.</p>","PeriodicalId":12639,"journal":{"name":"Frontiers in Neuroscience","volume":"19 ","pages":"1581266"},"PeriodicalIF":3.2,"publicationDate":"2025-06-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12186156/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144484096","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A scalable neural network emulator with MRAM-based mixed-signal circuits.","authors":"Jua Lee, Jiho Song, Hyeon Seong Im, Jonghwi Kim, Woonjae Lee, Wooseok Yi, Soonwan Kwon, Byungsu Jung, Joohyoung Kim, Yoonmyung Lee, Jung-Hoon Chun","doi":"10.3389/fnins.2025.1599144","DOIUrl":"10.3389/fnins.2025.1599144","url":null,"abstract":"<p><p>In this study, we present a mixed-signal framework that utilizes MRAM (Magneto-resistive Random Access Memory) technology to emulate behaviors observed in biological neural networks on silicon substrates. While modern technology increasingly draws inspiration from biological neural networks, fully understanding these complex systems remains a significant challenge. Our framework integrates multi-bit MRAM synapse arrays and analog circuits to replicate essential neural functions, including Leaky Integrate and Fire (LIF) dynamics, Excitatory and Inhibitory Postsynaptic Potentials (EPSP and IPSP), the refractory period, and the lateral inhibition. A key challenge in using MRAM for neuromorphic systems is its low on/off resistance ratio, which limits the accuracy of current-mode analog computation. To overcome this, we introduce a current subtraction architecture that reliably generates multi-level synaptic currents based on MRAM states. This enables robust analog neural processing while preserving MRAM's advantages, such as non-volatility and CMOS compatibility. The chip's adjustable operating frequency allows it to replicate biologically realistic time scales as well as accelerate experimental processes. Experimental results from fabricated chips confirm the successful emulation of biologically inspired neural dynamics, demonstrating the feasibility of MRAM-based analog neuromorphic computation for real-time and scalable neural emulation.</p>","PeriodicalId":12639,"journal":{"name":"Frontiers in Neuroscience","volume":"19 ","pages":"1599144"},"PeriodicalIF":3.2,"publicationDate":"2025-06-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12183957/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144474910","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Editorial: Neurobiological underpinnings of neurodegenerative and neuropsychiatric disorders: from models to therapy.","authors":"Ferdinando Di Cunto, Maria Vincenza Catania, Nicola Simola, Jessica Mingardi, Marcello Serra, Federica Campanelli","doi":"10.3389/fnins.2025.1627262","DOIUrl":"https://doi.org/10.3389/fnins.2025.1627262","url":null,"abstract":"","PeriodicalId":12639,"journal":{"name":"Frontiers in Neuroscience","volume":"19 ","pages":"1627262"},"PeriodicalIF":3.2,"publicationDate":"2025-06-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12183752/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144474911","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Local arrangement of microfibrillar-associated protein 5 with neurovascular and extracellular components in non- and ischemia-affected brain regions of mice.","authors":"Corinna Höfling, Steffen Roßner, Bianca Flachmeyer, Wolfgang Härtig, Dominik Michalski","doi":"10.3389/fnins.2025.1593948","DOIUrl":"10.3389/fnins.2025.1593948","url":null,"abstract":"<p><p>Stroke often leads to death or functional impairment, and neuroprotective strategies are still lacking. Among the mechanisms contributing to tissue damage and yielding thus interest for therapeutic interventions, an affection of cytoskeletal elements has been considered. A first description of the microfibrillar-associated protein 5 (MFAP5) has yielded a fiber-like pattern and reduced immunosignals in the ischemic brain. However, details on region characteristics are lacking. This study thus aimed to explore local arrangements of MFAP5 with components of the neurovascular unit and extracellular matrix in non- and ischemia-affected neocortical brain regions of mice. Immunofluorescence labeling was used to visualize MFAP5 simultaneously with neurons, glial cells, vasculature, perineuronal nets, fibronectin, and the cytoskeletal elements neurofilament light chain (NF-L) and microtubule-associated protein 2 (MAP2). Fluorescence-based microscopy, confocal laser scanning microscopy, and 3D surface reconstruction served for analyses. MFAP5 was observed in a predominantly fiber-like and partially surrounding formation associated with neuronal processes and cell bodies. In the ischemic region, MFAP5 markedly diminished, but a few fiber-like structures were maintained with a thinned, partially fragmented, and twisted aspect. MFAP5 exhibited no clear regional association with microglia, astroglia, or parts of the vasculature and ECM. However, the local arrangement of MFAP5 and its change due to ischemia was comparable to that of NF-L and MAP2. This study comprehensively described MFAP5 after experimental stroke and identified similarities with MAP2 and NF-L. Thus, MFAP5 might represent an essential component of the neuronal cytoskeleton. Further research is needed to explore its functional properties and potential for neuroprotective approaches.</p>","PeriodicalId":12639,"journal":{"name":"Frontiers in Neuroscience","volume":"19 ","pages":"1593948"},"PeriodicalIF":3.2,"publicationDate":"2025-06-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12179212/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144474913","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mechanisms of brain overgrowth in autism spectrum disorder with macrocephaly.","authors":"Laura Currey, Tracey Harvey, Alexandra Pelenyi, Michael Piper, Stefan Thor","doi":"10.3389/fnins.2025.1586550","DOIUrl":"10.3389/fnins.2025.1586550","url":null,"abstract":"<p><p>Autism spectrum disorder (ASD) is a highly prevalent human disorder with extensive clinical and genetic heterogeneity. One notable ASD subgroup that often manifest with more severe symptoms comprises individuals with an enlarged head (macrocephaly), often accompanied by an enlarged brain (megalencephaly). Here, we focus on the macrocephalic ASD subgroup and discuss the biological processes that may underlie brain overgrowth in individuals with ASD, including excess neurogenesis or gliogenesis, decreased cell death, neuronal hypertrophy, and elevated myelination. We also discuss the signaling and epigenetic pathways implicated in macrocephalic ASD. By examining the biological processes and the molecular pathways involved we seek to provide insight into the mechanisms underpinning macrocephalic ASD.</p>","PeriodicalId":12639,"journal":{"name":"Frontiers in Neuroscience","volume":"19 ","pages":"1586550"},"PeriodicalIF":3.2,"publicationDate":"2025-06-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12179084/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144474914","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The <i>RELN</i> heterozygous single-nucleotide polymorphism rs362691 increases the prefrontal cortical thickness and modulates systemizing-related autistic tendencies in typically developing children and adolescents.","authors":"Hiroki Sato, Mitsunari Abe, Hikaru Takeuchi, Hiroaki Tomita, Shigeo Kure, Ryuta Kawashima, Yasuyuki Taki","doi":"10.3389/fnins.2025.1574700","DOIUrl":"10.3389/fnins.2025.1574700","url":null,"abstract":"<p><p>Reelin, a glycoprotein, plays an essential role in the development and maturation of neural circuits in the cerebral cortex during embryonic and postnatal stages. Animal and human studies suggest that insufficient reelin signaling due to RELN mutations may alter the functional properties of the prefrontal cortex and contribute to cortical dysplasia in the frontal and temporal lobes. A heterozygous missense mutation in RELN, rs362691 (p. Leu997Val), has been proposed to increase susceptibility to autism spectrum disorder (ASD). Based on the empathizing-systemizing theory, this study examined whether the rs362691 variant affects cortical thickness and modulates autism-related cognitive traits in typically developing children and adolescents. We hypothesized that individuals carrying the heterozygous Val/Leu genotype would exhibit greater prefrontal cortical thickness than those with the Val/Val genotype, and that this morphological difference would correlate with autistic cognitive traits. We also explored potential thickness differences in the frontal and temporal cortices. Our results showed that the heterozygous Val/Leu group did not differ from the Val/Val group in empathizing or systemizing trait scores. However, individuals with the Val/Leu genotype exhibited increased cortical thickness in the medial prefrontal sulci, which correlated with individual differences in systemizing traits. No significant association was observed between cortical thickness and empathizing traits across the whole brain. Additionally, greater cortical thickness was observed in the right superior temporal sulcus (STS), although this morphological difference was not associated with empathizing or systemizing traits. These findings suggest that while the rs362691 variant does not significantly influence autism-related cognitive styles per se, it may alter cortical morphology in prefrontal regions functionally linked to systemizing traits in typically developing individuals. Several methodological limitations in the employed data should be considered. Future studies with larger, age-appropriate cohorts and standardized personality measures will be necessary to validate and extend these findings.</p>","PeriodicalId":12639,"journal":{"name":"Frontiers in Neuroscience","volume":"19 ","pages":"1574700"},"PeriodicalIF":3.2,"publicationDate":"2025-06-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12179114/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144474916","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"New variants and genotype-phenotype correlation of <i>PPP3CA</i>-related developmental and epileptic encephalopathy.","authors":"Ting Wang, Shijia Ouyang, Xueyang Niu, Miaomiao Cheng, Ying Yang, Yonghua Yang, Quanzhen Tan, Wenwei Liu, Xiaoling Yang, Yuehua Zhang","doi":"10.3389/fnins.2025.1570997","DOIUrl":"10.3389/fnins.2025.1570997","url":null,"abstract":"<p><strong>Objective: </strong>To explore the genotypic spectrum and refine the genotype-phenotype correlation of <i>PPP3CA</i>-related developmental and epileptic encephalopathy (DEE).</p><p><strong>Methods: </strong>whole-exome sequencing or whole-genome sequencing was performed to all patients. Clinical data of 15 epilepsy patients in current study and 21 epilepsy patients from published studies were collected and analyzed.</p><p><strong>Results: </strong>In this study, 15 patients were identified with 13 <i>de novo PPP3CA</i> variants. Among these, seven frameshift variants and one gene inversion between intron 11 and intron 13 (including exons 12 and 13) were novel. 80% of patients experiencing seizure onset before the age of one. The seizure types observed included epileptic spasms (93.3%), tonic seizures (46.7%), myoclonic seizures (46.7%), focal seizures (40.0%), atypical absence seizures (13.3%), generalized tonic-clonic seizures (6.7%) and myoclonic atonic seizures (6.7%). All patients exhibited global developmental delay. MRI abnormalities were noticed in 9 patients, including widened subarachnoid space, bilateral ventricular width, poor myelination of white matter, and dysplasia of the corpus callosum. 80% specifically diagnosed with infantile epileptic spasms syndrome (IESS). When combining data from this study and published studies, 66.7% of patients experienced seizure onset before the age of one, and 77.8% were diagnosed with IESS. In patients with variants located in the catalytic domain (CD), 45.4% patients exhibited multiple seizure types, while 45.4% patients presented only with epileptic spasms. In contrast, among patients with variants in regulatory domain (RD), 87% had multiple seizure types and only 8.7% had epileptic spasms alone. Additionally, 45.5% of patients with CD variants had comorbid autism spectrum disorders, compared to 13% patients with RD variants. Recurrent variants included p.His92Arg, p.Asp234Glu, p.Glu282Lys, and p.Ser419Asnfs*31.</p><p><strong>Conclusion: </strong>This study is the first to report a gene inversion in <i>PPP3CA</i>-related DEE. Patients with only epileptic spasms were more prevalent in those with CD variants, compared to those with RD variants. Conversely, patients with multiple seizure types were more common among those with RD variants. The most frequently diagnosed epileptic syndrome was IESS. Additionally, comorbid ASD were more commonly observed in patients with CD variants than in those with RD variants.</p>","PeriodicalId":12639,"journal":{"name":"Frontiers in Neuroscience","volume":"19 ","pages":"1570997"},"PeriodicalIF":3.2,"publicationDate":"2025-06-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12179222/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144474915","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Editorial: Neuroinflammation and gut-brain axis: role of glia cells.","authors":"Deiziane V S Costa, Danielle S Macedo, Camila N C Lima","doi":"10.3389/fnins.2025.1618286","DOIUrl":"10.3389/fnins.2025.1618286","url":null,"abstract":"","PeriodicalId":12639,"journal":{"name":"Frontiers in Neuroscience","volume":"19 ","pages":"1618286"},"PeriodicalIF":3.2,"publicationDate":"2025-06-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12179094/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144474912","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Recanalization and reperfusion in clinically-relevant porcine model of stroke.","authors":"Błażej Nowak, Piotr Holak, Izabela Małysz-Cymborska, Alexandra Chovsepian, Yanina Dening, Jarosław Olszewski, Aleksandra Piecuch, Maria Jasieniak, Jakub Jasieniak, Arkadiusz Szterk, Maria Sady, Karolina Ferenc, Daniel Berchtold, Artur Jabłoński, Romuald Zabielski, Zdzisław Gajewski, Tim Magnus, Mirosław Janowski, Piotr Walczak, Andreas Meisel, Francisco Pan-Montojo, Dominika Gołubczyk","doi":"10.3389/fnins.2025.1572925","DOIUrl":"10.3389/fnins.2025.1572925","url":null,"abstract":"<p><strong>Introduction: </strong>Stroke is a leading cause of death and long-term disability. Pigs have been considered an ideal large animal model in biomedicine; however, the complex vascular anatomy has posed challenges for stroke research. Nonetheless, we have previously overcome these limitations and demonstrated the feasibility of endovascularly inducing stroke in pigs. Here, we study to further mimic clinical situation by achieving recanalization, which has not been previously accomplished.</p><p><strong>Methods: </strong>A stroke was induced in eight juvenile male domestic pigs. In anaestethised animals catheter was placed in the ascending pharyngeal artery near the rete mirabile (RM) under X-ray guidance. The animals were then transferred to an MRI scanner. Gadolinium-based contrast agent (GBCA) was infused at various speeds until transcatheter cerebral perfusion was visible on MRI. Subsequently, a mixture of thrombin and GBCA was infused, and the retention of contrast on MRI scans proved successful induction of thrombosis. Subsequent DWI and PWI MR images confirmed the successful induction of stroke. Two hours after ischemia, we intra-arterially infused rtPA (20 mg) and confirmed recanalization of the thrombosed vessels using MRI. One month later the stroke was confirmed through follow-up MRI scans and post-mortem histological and immunohistochemical analyses.</p><p><strong>Results: </strong>We successfully induced stroke with an average lesion size based on ADC at 8.18 ± 4.98 cm³, ranging from 3.27 to 17.33 cm³. After recanalization, the severely hypoperfused area (Tmax>6) was only 1.168 ± 0.223 cm³. Subsequent histological analysis revealed neuronal loss within the lesion, the formation of astrocytic scar tissue, and elevated levels of activated microglia.</p><p><strong>Discussion: </strong>Our study demonstrates the successful recanalization of cerebral vasculature in porcine model of ischemic stroke. It makes the model highly relevant to the current clinical workflow and offers an attractive avenue for studying novel diagnostics, therapeutics and further exploration of the underlying pathomechanisms. The feasibility of continuous MR imaging throughout the entire procedure facilitates the achievement of the aforementioned goals more readily.</p>","PeriodicalId":12639,"journal":{"name":"Frontiers in Neuroscience","volume":"19 ","pages":"1572925"},"PeriodicalIF":3.2,"publicationDate":"2025-06-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12176772/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144332991","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Music-induced cognitive change and whole-brain network flexibility: a pilot study.","authors":"E Lydia Wu-Chung, Melia E Bonomo, Anthony K Brandt, Bryan T Denny, Christof Karmonik, J Todd Frazier, Karl Blench, Christopher P Fagundes","doi":"10.3389/fnins.2025.1567605","DOIUrl":"10.3389/fnins.2025.1567605","url":null,"abstract":"<p><strong>Introduction: </strong>Cognitive impairment that exceeds age-related cognitive decline is a risk factor for Alzheimer's disease and related dementias. As the older adult population is notably increasing every year, significant efforts are being made to preserve cognitive function in older adulthood. Non-pharmaceutical approaches such as music interventions have noticeable benefits for cognition. Music engagement utilizes multiple brain regions dually involved in higher cognitive functions. Yet the neurobiology of music-induced cognitive change remains understudied. Complex human behavior and cognition likely depend on continuous communication across brain regions rather than localized activity in one region. Given that music creativity engages a wide range of mental processes, whole-brain network indices quantifying the brain's tendency to create functional communities (modularity) and then dynamically reorganize these communities (flexibility) may be relevant for assessing music-related cognitive change. Using a semi-randomized clinical trial design (ClinicalTrials.gov; NCT04137913), we examined whether (1) music creativity altered whole-brain network indices (modularity, flexibility) and (2) whether music-related effects on cognition depended on whole-brain network indices.</p><p><strong>Methods: </strong>Fifty-two older adults (Mean age = 75 years; 54% female; 84% White) were randomized to a 6-week music creativity intervention (<i>n</i> = 25) or a no-treatment control condition (<i>n</i> = 27) and completed resting-state fMRI scans and the Montreal Cognitive Assessment at baseline and follow-up (post-intervention).</p><p><strong>Results: </strong>The music creativity intervention did not alter network flexibility or modularity over time. However, the relationship between group assignment and change in global cognitive function depended on baseline flexibility: music creativity improved global cognition more than the control condition, only among individuals who had higher than average network flexibility.</p><p><strong>Discussion: </strong>Findings suggest that having a dynamic brain network, which has previously been linked to better executive functioning performance, may be necessary for music-related benefits on cognition. This pilot study is innovative as it is among the first to identify possible neural mechanisms underlying why music creativity interventions confer a more significant cognitive benefit for some older adults than others.</p>","PeriodicalId":12639,"journal":{"name":"Frontiers in Neuroscience","volume":"19 ","pages":"1567605"},"PeriodicalIF":3.2,"publicationDate":"2025-06-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12176889/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144332990","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}