Frontiers in Neuroscience最新文献

{"title":"Neural mechanisms underlying synchronization of movement to musical cues in Parkinson disease and aging.","authors":"Elinor C Harrison, Sarah Grossen, Lauren E Tueth, Allison M Haussler, Kerri S Rawson, Meghan C Campbell, Gammon M Earhart","doi":"10.3389/fnins.2025.1550802","DOIUrl":"10.3389/fnins.2025.1550802","url":null,"abstract":"<p><strong>Introduction: </strong>External and internal musical cues provide therapeutic techniques for gait rehabilitation in aging and neurological disorders. For people with Parkinson disease (PwPD), mental singing is a type of internal cue that can regularize gait timing. No studies to date have directly measured brain activity during external and internal musical cues as used in gait rehabilitation. Evidence suggests the neural mechanisms of external vs. internal cued movement differ. External cues are thought to drive movement via recruitment of cerebello-thalamo-cortical (CTC) pathways, while internal cues are thought to rely more on striato-pallido-thalamocortical (SPT) pathways.</p><p><strong>Methods: </strong>We investigated the neural mechanisms that underlie acute responses to external cues (listening to music) and internal cues (mental singing). Using fMRI, we imaged PwPD and age-matched healthy controls (HC) while performing finger tapping during musical cueing tasks.</p><p><strong>Results: </strong>No differences were seen between PwPD and HC in any of the comparisons. Functional imaging results showed activation of sensorimotor cortex, temporal gyri, supplementary motor areas, and putamen for both cueing tasks. External cues additionally activated auditory cortex while internal cues additionally activated the cerebellum. When directly comparing cue types, external cues displayed greater activity in the primary auditory cortex and temporal gyri.</p><p><strong>Discussion: </strong>These results suggest similar brain regions are activated during musically-cued movements for both PwPD and HC and both cue types utilize parallel pathways for processing. Both cue types may facilitate use of remaining function of areas that degenerate in PD (e.g., putamen) and potentially also activate routes through less impaired areas (e.g., cerebellum). This supports the idea that the CTC and SPT pathways work in tandem and facilitate sensorimotor activity via a complex interplay between neural circuits. These findings have implications for how external and internal cues may be administered in future therapies.</p>","PeriodicalId":12639,"journal":{"name":"Frontiers in Neuroscience","volume":"19 ","pages":"1550802"},"PeriodicalIF":3.2,"publicationDate":"2025-03-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11933100/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143709735","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Radiation-induced white matter dysfunction in patients with nasopharyngeal carcinoma.","authors":"Xingyou Zheng, Li Li, Jian-Ming Gao, Yang Hu, Limeng Deng, Ya-Fei Kang, Youming Zhang","doi":"10.3389/fnins.2025.1548744","DOIUrl":"10.3389/fnins.2025.1548744","url":null,"abstract":"<p><p>Radiation-induced structural abnormalities in white matter (WM) have been reported in patients with nasopharyngeal carcinoma (NPC); however, the alterations in functional domain were insufficiently investigated. A total of 111 NPC patients were included and these patients, based on whether completed radiation therapy (RT) or not, were divided into pre-RT (<i>n</i> = 47) and post-RT (<i>n</i> = 64) groups. Functional connectivity strength (FCS) between WM regions (WW-FCS) and between WM and gray matter (GM) regions (GW-FCS) was used to investigate the radiation-induced changes in WM function. Compared with the pre-RT patients, post-RT NPC patients showed decreased WW-FCS in the left superior cerebellar peduncle, right anterior limb of internal capsule, bilateral posterior thalamic radiation, and left tapetum. Compared with the pre-RT patients, post-RT NPC patients showed decreased GW-FCS in the left caudate, bilateral visual cortex, and the right ventral prefrontal cortex. In the post-RT group, the GW-FCS in left visual cortex was negatively correlated with radiation dosage for the brain stem (r = -0.35, <i>p</i> = 0.039), and for the left temporal lobe (r = -0.46, <i>p</i> = 0.0058). The GW-FCS in right visual cortex was negatively correlated with radiation dosage for the left temporal lobe (r = -0.38, <i>p</i> = 0.025). Our findings of decreased WW-FCS and GW-FCS in such brain regions (such as visual cortex, posterior thalamic radiation, and anterior limb of internal capsule, as well as superior cerebellar peduncle) suggest potential functional impairments in visual and motor systems.</p>","PeriodicalId":12639,"journal":{"name":"Frontiers in Neuroscience","volume":"19 ","pages":"1548744"},"PeriodicalIF":3.2,"publicationDate":"2025-03-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11931022/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143700310","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Neurophysiological characteristics of reward processing in deaf college students under different social contexts.","authors":"Xue Du, Ting Huang, Shiqiong Wu, Xingru Wang, Xiaoyi Chen","doi":"10.3389/fnins.2025.1524443","DOIUrl":"10.3389/fnins.2025.1524443","url":null,"abstract":"<p><strong>Background: </strong>In the context of social exclusion, individuals tend to make choices that are advantageous to themselves and optimize their interests. Due to hearing impairment, deaf college students face more social exclusion in our society. However, the neural mechanisms of reward processing in deaf college students during different situations of social exclusion remain unknown.</p><p><strong>Methods: </strong>A total of 27 deaf college students completed the monetary and social reward delay tasks while recording event-related potential (ERP) data.</p><p><strong>Results: </strong>The behavioral hit rate was sensitive to the main effect of social context; that is, the deaf college students showed a higher hit rate in social inclusion than in social exclusion. The amplitude of Cue P3 elicited by reward cues was found to be higher in social exclusion than in social inclusion, particularly when the amplitudes of monetary cues were higher than those of social cues. In the reward feedback outcome phase, small magnitude induced a greater feedback-evoked P3 than large magnitude. Additionally, they exhibited a large feedback-related negativity amplitude for large-magnitude (but not for small-magnitude) monetary reward cues.</p><p><strong>Conclusion: </strong>Deaf college students were more sensitive to reward cues in social exclusion than in social inclusion, especially to monetary cues, and more concerned with attaining greater monetary gains.</p>","PeriodicalId":12639,"journal":{"name":"Frontiers in Neuroscience","volume":"19 ","pages":"1524443"},"PeriodicalIF":3.2,"publicationDate":"2025-03-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11931012/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143700306","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Neural signatures of extreme sensitivities to light: cortical markers in hypersensitive and hyposensitive individuals via EEG.","authors":"Valerio Salvati, Satoru Otani, Elisa M Tartaglia","doi":"10.3389/fnins.2025.1542154","DOIUrl":"10.3389/fnins.2025.1542154","url":null,"abstract":"<p><p>Light plays a crucial role in human biology. However, while the general pathways involved in light perception are well-understood, the specific neural mechanisms explaining why some individuals experience an adverse behavioral response to light (hypersensitivity), while others rather the opposite (hyposensitivity) remain unclear. Here, leveraging the high temporal resolution of EEG, we set out to test the hypothesis that, in hyposensitive individuals, an excessive sensory stimulation may lead to neural hyper-excitability. Such an enhanced response, in turn, might be key to mitigate discomfort. We conducted our study on 21 participants, who underwent light exposure tests at varying intensities. Our findings revealed that hyposensitive individuals, who are less averse to intense light exposure, can rely on a more efficient neuroprotective mechanism against sensory overload, when compared to hypersensitive individuals. Such a mechanism is mainly and consistently expressed through the increase in power of beta and gamma oscillations, along with a delayed onset of the P100 component in response to light stimuli. These findings open the door for future research to adaptive technologies that utilize EEG markers to create personalized, real-time interventions for light sensitivity, such as adaptive wearable devices or environmental systems that dynamically adjust lighting based on neural feedback, providing immediate relief for hypersensitive individuals.</p>","PeriodicalId":12639,"journal":{"name":"Frontiers in Neuroscience","volume":"19 ","pages":"1542154"},"PeriodicalIF":3.2,"publicationDate":"2025-03-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11931066/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143700298","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Automatic brain quantification in children with unilateral cerebral palsy.","authors":"Jaime Simarro, Thibo Billiet, Thanh Vân Phan, Simon Van Eyndhoven, Monica Crotti, Lize Kleeren, Lisa Mailleux, Nofar Ben Itzhak, Diana M Sima, Els Ortibus, Ahmed M Radwan","doi":"10.3389/fnins.2025.1540480","DOIUrl":"10.3389/fnins.2025.1540480","url":null,"abstract":"<p><p>Assessing brain damage in children with spastic unilateral cerebral palsy (uCP) is challenging, particularly in clinical settings. In this study, we developed and validated a deep learning-based pipeline to automatically quantify lesion-free brain volumes. Using T1-weighted and FLAIR MRI data from 35 patients (aged 5-15 years), we trained models to segment brain structures and lesions, utilizing an automatic label generation workflow. Validation was performed on 54 children with CP (aged 7-16 years) using quantitative and qualitative metrics, as well as an independent dataset of 36 children with congenital or acquired brain anatomy distortions (aged 1-17 years). Clinical evaluation examined the correlation of lesion-free volumes with visual-based assessments of lesion extent and motor and visual outcomes. The models achieved robust segmentation performance in brains with severe anatomical alterations and heterogeneous lesion appearances, identifying reduced volumes in the affected hemisphere, which correlated with lesion extent (<i>p</i> < 0.05). Further, regional lesion-free volumes, especially in subcortical structures such as the thalamus, were linked to motor and visual outcomes (<i>p</i> < 0.05). These results support the utility of automated lesion-free volume quantification for exploring brain structure-function relationships in uCP.</p>","PeriodicalId":12639,"journal":{"name":"Frontiers in Neuroscience","volume":"19 ","pages":"1540480"},"PeriodicalIF":3.2,"publicationDate":"2025-03-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11931148/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143700251","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dysregulation of lipid metabolism, energy production, and oxidative stress in myalgic encephalomyelitis/chronic fatigue syndrome, Gulf War Syndrome and fibromyalgia.","authors":"Leah Davis, Maisy Higgs, Ailsa Snaith, Tiffany A Lodge, James Strong, Jose A Espejo-Oltra, Sławomir Kujawski, Paweł Zalewski, Etheresia Pretorius, Michael Hoerger, Karl J Morten","doi":"10.3389/fnins.2025.1498981","DOIUrl":"10.3389/fnins.2025.1498981","url":null,"abstract":"<p><p>Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS), Gulf War Syndrome (GWS), and Fibromyalgia (FM) are complex, chronic illnesses with overlapping clinical features. Symptoms that are reported across these conditions include post-exertional malaise (PEM), fatigue, and pain, yet the etiology of these illnesses remains largely unknown. Diagnosis is challenging in patients with these conditions as definitive biomarkers are lacking; patients are required to meet clinical criteria and often undergo lengthy testing to exclude other conditions, a process that is often prolonged, costly, and burdensome for patients. The identification of reliable validated biomarkers could facilitate earlier and more accurate diagnosis and drive the development of targeted pharmacological therapies that might address the underlying pathophysiology of these diseases. Major driving forces for biomarker identification are the advancing fields of metabolomics and proteomics that allow for comprehensive characterization of metabolites and proteins in biological specimens. Recent technological developments in these areas enable high-throughput analysis of thousands of metabolites and proteins from a variety of biological samples and model systems, that provides a powerful approach to unraveling the metabolic phenotypes associated with these complex diseases. Emerging evidence suggests that ME/CFS, GWS, and FM are all characterized by disturbances in metabolic pathways, particularly those related to energy production, lipid metabolism, and oxidative stress. Altered levels of key metabolites in these pathways have been reported in studies highlighting potential common biochemical abnormalities. The precise mechanisms driving altered metabolic pathways in ME/CFS, GWS, and FM remain to be elucidated; however, the elevated oxidative stress observed across these illnesses may contribute to symptoms and offer a potential target for therapeutic intervention. Investigating the mechanisms, and their role in the disease process, could provide insights into disease pathogenesis and reveal novel treatment targets. As such, comprehensive metabolomic and proteomic analyses are crucial for advancing the understanding of these conditions in-order to identify both common, and unique, metabolic alterations that could serve as diagnostic markers or therapeutic targets.</p>","PeriodicalId":12639,"journal":{"name":"Frontiers in Neuroscience","volume":"19 ","pages":"1498981"},"PeriodicalIF":3.2,"publicationDate":"2025-03-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11931034/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143700254","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Editorial: Datasets for brain-computer interface applications, volume II.","authors":"Ian Daly, Ana Matran-Fernandez, Mikhail A Lebedev, Andrea Kübler, Davide Valeriani","doi":"10.3389/fnins.2025.1569216","DOIUrl":"10.3389/fnins.2025.1569216","url":null,"abstract":"","PeriodicalId":12639,"journal":{"name":"Frontiers in Neuroscience","volume":"19 ","pages":"1569216"},"PeriodicalIF":3.2,"publicationDate":"2025-03-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11931134/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143700257","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of neostigmine on postoperative neurocognitive dysfunction: a systematic review and meta-analysis.","authors":"Xuelei Zhou, Linlin Chen, Li Zhao, Wei Mao, Xianchun Liu, Longyi Zhang, Ying Xie, Linji Li","doi":"10.3389/fnins.2025.1464272","DOIUrl":"10.3389/fnins.2025.1464272","url":null,"abstract":"<p><strong>Introduction: </strong>Postoperative neurocognitive dysfunction (PND) is a common and serious complication following surgery. Neostigmine, an acetylcholinesterase inhibitor commonly administered during anesthesia to reverse residual neuromuscular blockade, has been suggested in recent studies to potentially reduce the incidence of PND. However, findings have been inconsistent across studies. Therefore, this study conducts a systematic review and meta-analysis to evaluate the effect of neostigmine on PND.</p><p><strong>Methods: </strong>We conducted a comprehensive literature search across multiple databases, including PubMed, EmBase, Web of Science, Cochrane Library, Scopus, SinoMed, and CNKI, to identify all relevant studies for inclusion. We included randomized controlled trials and cohort studies in our analysis. The risk of bias was assessed using the Risk of Bias 2 tool for randomized trials and the ROBINS-I tool for cohort studies.</p><p><strong>Results: </strong>A total of 11 studies were included in this analysis, consisting of 8 randomized controlled trials and 3 cohort studies. The incidence of PND was significantly lower in the neostigmine group compared to the control group (log(OR): -0.54, 95% CI [-1.04, -0. 05]; OR: 0.58, 95% CI: [0.35, 0.95], <i>p</i> = 0.03, I² = 81.95%). Sensitivity analysis led to the exclusion of one cohort study. Consequently, the final meta-analysis comprised 10 studies, encompassing a total of 50,881 participants. The results indicate that the incidence of PND was significantly lower in the neostigmine group compared to the control group (log(OR):-0. 27, 95% CI [-0.47, -0. 08]; OR: 0.76, 95% CI: [0.62, 0.91], <i>p</i> = 0.01, I² = 2.50%). However, Meta-analysis of RCTs and cohort studies showed no significant difference. Subgroup analysis indicated that neostigmine reduced the incidence of delayed neurocognitive recovery (dNCR), but its impact on POD was unclear, with no significant association to nausea and vomiting. These findings suggest that neostigmine may reduce the risk of PND, but caution is needed in interpretation.</p><p><strong>Conclusion: </strong>Neostigmine may have a potential positive effect in reducing the incidence of PND. However, no statistical difference was observed when meta-analyses were performed separately for randomized controlled trials (RCTs) and cohort studies. Given the limited number of studies available and the limitations of the current research, further investigation is needed to clarify the impact of neostigmine on PND.</p><p><strong>Systematic review registration: </strong>https://www.crd.york.ac.uk/PROSPERO/view/CRD42024537647, Identifier CRD42024537647.</p>","PeriodicalId":12639,"journal":{"name":"Frontiers in Neuroscience","volume":"19 ","pages":"1464272"},"PeriodicalIF":3.2,"publicationDate":"2025-03-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11925933/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143691906","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Magnetic sense-dependent probabilistic decision-making in humans.","authors":"In-Taek Oh, Soo-Chan Kim, Yongkuk Kim, Yong-Hwan Kim, Kwon-Seok Chae","doi":"10.3389/fnins.2025.1497021","DOIUrl":"10.3389/fnins.2025.1497021","url":null,"abstract":"<p><p>Even though it is not well characterized how much humans can sense the geomagnetic field (GMF), numerous magnetosensitive animals can detect GMF broadly as a sensory cue, when a spatial decision-making is needed for orientation or migration. In an article of recent series of studies, we showed that the empirical probabilities of stone selections in Go game were significantly different from the theoretical probability. In this study, we assessed the implication of the GMF in modulating subconscious non-spatial decision-making in human subjects and the underlying mechanism with exploiting the zero-sum binary stone selection of Go game as a proof-of-principle. In a laboratory setting, the experimental probability in a decision-making was significantly hampered by the cancelation of the ambient GMF. Moreover, the attenuation of decision-making was confirmed by a specific range of magnetic resonance radiofrequency. In numerous stone selection games among amateur Go players in the artificial magnetic field setting, the analyses of stone selection rate by trials and steps for decision-making pinpointed the subconscious stone selection as a primary modulating target in the binary decision-making. Our findings may provide unique insights into the impact of sensing GMF in probabilistic decision-making in which theoretical probability is manifested into empirical probability through a magnetic field resonance-dependent mechanism.</p>","PeriodicalId":12639,"journal":{"name":"Frontiers in Neuroscience","volume":"19 ","pages":"1497021"},"PeriodicalIF":3.2,"publicationDate":"2025-03-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11925921/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143691918","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"AM-MTEEG: multi-task EEG classification based on impulsive associative memory.","authors":"Junyan Li, Bin Hu, Zhi-Hong Guan","doi":"10.3389/fnins.2025.1557287","DOIUrl":"10.3389/fnins.2025.1557287","url":null,"abstract":"<p><p>Electroencephalogram-based brain-computer interfaces (BCIs) hold promise for healthcare applications but are hindered by cross-subject variability and limited data. This article proposes a multi-task (MT) classification model, AM-MTEEG, which integrates deep learning-based convolutional and impulsive networks with bidirectional associative memory (AM) for cross-subject EEG classification. AM-MTEEG deals with the EEG classification of each subject as an independent task and utilizes common features across subjects. The model is built with a convolutional encoder-decoder and a population of impulsive neurons to extract shared features across subjects, as well as a Hebbian-learned bidirectional associative memory matrix to classify EEG within one subject. Experimental results on two BCI competition datasets demonstrate that AM-MTEEG improves average accuracy over state-of-the-art methods and reduces performance variance across subjects. Visualization of neuronal impulses in the bidirectional associative memory network reveal a precise mapping between hidden-layer neuron activities and specific movements. Given four motor imagery categories, the reconstructed waveforms resemble the real event-related potentials, highlighting the biological interpretability of the model beyond classification.</p>","PeriodicalId":12639,"journal":{"name":"Frontiers in Neuroscience","volume":"19 ","pages":"1557287"},"PeriodicalIF":3.2,"publicationDate":"2025-03-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11922916/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143669516","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}