Frontiers in Neuroscience最新文献

{"title":"Enhancement sensitivity of TRPV1 in dorsal root ganglia via the SP-NK-1 pathway contributes to increased bladder organ sensitivity caused by prostatitis.","authors":"ZhiPeng Jiang, Wen Luo, Lei Liu, ZongMin Long","doi":"10.3389/fnins.2024.1484980","DOIUrl":"10.3389/fnins.2024.1484980","url":null,"abstract":"<p><p>Chronic prostatitis/chronic pelvic pain syndrome is a prevalent condition affecting the male urinary system. The urinary dysfunction resulting from this disorder has a direct or indirect impact on the patient's quality of life. Recent studies have suggested that organ cross-sensitization between the prostate and bladder may elucidate this phenomenon; however, the specific molecular mechanisms remain unclear. In this study, we simulated the urinary symptoms of prostatitis patients using an animal model and examined the expression of relevant proteins within the prostate-bladder sensitized neural pathway. We found that transient receptor potential vanilloid 1 (TRPV1) protein is highly expressed in the dorsal root ganglia (DRG) that co-innervate both the prostate and bladder, potentially increasing the sensitivity of TRPV1 channels via the substance P-neurokinin 1 (SP-NK-1) pathway, which may exacerbate micturition symptoms. Furthermore, in the absence of bladder inflammation, elevated levels of neurogenic substances in bladder tissue were found to sensitize bladder sensory afferents. Collectively, these results underscore the significant role of TRPV1 in bladder sensitization associated with prostatitis, suggesting that the inhibition of TRPV1 along this sensitization pathway could be a promising approach to treating urinary dysfunction linked to prostatitis in the future.</p>","PeriodicalId":12639,"journal":{"name":"Frontiers in Neuroscience","volume":null,"pages":null},"PeriodicalIF":3.2,"publicationDate":"2024-10-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11560851/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142618632","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reproductive hormones and sex chromosomes drive sex differences in the sleep-wake cycle.","authors":"Micah Ralston, J Christopher Ehlen, Ketema Paul","doi":"10.3389/fnins.2024.1478820","DOIUrl":"10.3389/fnins.2024.1478820","url":null,"abstract":"<p><p>There are well-documented gender differences in the risk and severity of sleep disorders and associated comorbidities. While fundamental sex differences in sleep regulatory mechanisms may contribute to gender disparities, biological responses to sleep loss and stress may underlie many of the risks for sleep disorders in women and men. Some of these sex differences appear to be dependent on sex chromosome complement (XX or XY) and the organizational effects of reproductive hormones. Reproductive development plays a critical role in the ability of sex chromosomes and reproductive hormones to produce sex differences in sleep and wakefulness. Rodent models reveal that reproductive hormones drive many but not all sex differences in sleep-wake architecture. The ability of reproductive hormones to alter sleep are often dependent on responses to sleep loss and stress. However, in the absence of reproductive hormones (in gonadectomized rodents) sex differences in sleep amount and the ability to recover from sleep loss persist. The suprachiasmatic nucleus (SCN) and the ventrolateral preoptic nucleus (VLPO) of the hypothalamus play crucial regulatory roles in mediating the effects of reproductive hormones on the sleep-wake cycle. Taken together, the work reviewed here reveals that the reproductive hormone environment and sex chromosome complement may underlie gender disparities in sleep patterns and the risk for sleep disorders.</p>","PeriodicalId":12639,"journal":{"name":"Frontiers in Neuroscience","volume":null,"pages":null},"PeriodicalIF":3.2,"publicationDate":"2024-10-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11561190/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142618638","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Editorial: From theory to practice: the latest developments in neuromorphic computing applications.","authors":"Arash Ahmadi, Shaghayegh Gomar, Majid Ahmadi","doi":"10.3389/fnins.2024.1511987","DOIUrl":"https://doi.org/10.3389/fnins.2024.1511987","url":null,"abstract":"","PeriodicalId":12639,"journal":{"name":"Frontiers in Neuroscience","volume":null,"pages":null},"PeriodicalIF":3.2,"publicationDate":"2024-10-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11557524/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142618622","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Beyond anosmia: olfactory dysfunction as a common denominator in neurodegenerative and neurodevelopmental disorders.","authors":"Yu-Nan Chen, Johanna Katharina Kostka","doi":"10.3389/fnins.2024.1502779","DOIUrl":"10.3389/fnins.2024.1502779","url":null,"abstract":"<p><p>Olfactory dysfunction has emerged as a hallmark feature shared among several neurological conditions, including both neurodevelopmental and neurodegenerative disorders. While diseases of both categories have been extensively studied for decades, their association with olfaction has only recently gained attention. Olfactory deficits often manifest already during prodromal stages of these diseases, yet it remains unclear whether common pathophysiological changes along olfactory pathways cause such impairments. Here we probe into the intricate relationship between olfactory dysfunction and neurodegenerative and neurodevelopmental disorders, shedding light on their commonalities and underlying mechanisms. We begin by providing a brief overview of the olfactory circuit and its connections to higher-associated brain areas. Additionally, we discuss olfactory deficits in these disorders, focusing on potential common mechanisms that may contribute to olfactory dysfunction across both types of disorders. We further debate whether olfactory deficits contribute to the disease propagation or are simply an epiphenomenon. We conclude by emphasizing the significance of olfactory function as a potential pre-clinical diagnostic tool to identify individuals with neurological disorders that offers the opportunity for preventive intervention before other symptoms manifest.</p>","PeriodicalId":12639,"journal":{"name":"Frontiers in Neuroscience","volume":null,"pages":null},"PeriodicalIF":3.2,"publicationDate":"2024-10-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11557544/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142618614","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy comparison of five antidepressants in treating anxiety and depression in cancer and non-cancer patients.","authors":"Kuan Zhao, Youyang Wang, Qun Liu, Ze Yu, Wei Feng","doi":"10.3389/fnins.2024.1485179","DOIUrl":"10.3389/fnins.2024.1485179","url":null,"abstract":"<p><strong>Introduction: </strong>Cancer patients have a heightened susceptibility to anxiety and depressive disorders, which significantly impact the effectiveness of cancer treatments and long-term quality of life. This study aimed to compare the efficacy of different antidepressants in cancer and non-cancer patients.</p><p><strong>Methods: </strong>A total of 610 patients diagnosed with depressive episodes and/or anxiety disorders were retrospectively included and divided into a cancer group and a non-cancer control group. Antidepressants used included escitalopram, duloxetine, sertraline, venlafaxine, and vortioxetine, combined with trazodone or not. The Patient Health Questionnaire-9 (PHQ-9) and the Generalized Anxiety Disorder Questionnaire-7 (GAD-7) scores were used to evaluate the efficacy after 4 weeks and 8 weeks of systematic antidepressants treatment.</p><p><strong>Results: </strong>Compared to the non-cancer group, the cancer group had higher proportions of females, older individuals, and patients with poor sleep quality, while reporting fewer somatic symptoms at baseline (all <i>p</i> < 0.05). PHQ-9 and GAD-7 scores in cancer patients treated with antidepressants were significantly lower than baseline at week 4 and week 8 (all <i>p</i> < 0.05). The sertraline group demonstrated significantly less improvement in GAD-7 scores at week 4 and in both GAD-7 and PHQ-9 scores at week 8 compared to the escitalopram group, while duloxetine, venlafaxine, and vortioxetine showed comparable efficacy to escitalopram. Antidepressants combined with trazodone showed significant improvement in PHQ-9 scores at week 4 compared to those without trazodone. The gynecological cancer group showed significantly more improvement in GAD-7 and PHQ-9 scores at week 4 and 8 compared to breast cancer patients.</p><p><strong>Conclusion: </strong>Antidepressant treatment in cancer patients with anxiety and depression is as effective as in non-cancer patients. The efficacy of escitalopram is comparable to duloxetine, venlafaxine, and vortioxetine, all of which outperformed sertraline in cancer patients.</p>","PeriodicalId":12639,"journal":{"name":"Frontiers in Neuroscience","volume":null,"pages":null},"PeriodicalIF":3.2,"publicationDate":"2024-10-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11557551/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142618625","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Task-switching mechanisms under methamphetamine cravings: sex differences in cued and voluntary task-switching.","authors":"Huan Jiang, BinJie Yang, HanZhi Huang, Dong Zhao, HuiLing Li, ZhiYing Chen, Shengyi Jin, Qiang Zhou","doi":"10.3389/fnins.2024.1462157","DOIUrl":"10.3389/fnins.2024.1462157","url":null,"abstract":"<p><strong>Introduction: </strong>This study explored the effects of task-switching type and sex on the task-switching ability of methamphetamine abstainers, as well as the differences in brain mechanisms under drug cravings under drug cravings using near-infrared spectroscopy.</p><p><strong>Methods: </strong>Craving-inducing videos were used to arouse 20 methamphetamine abstainers (including 10 men), whose switching ability was then assessed using voluntary and cued task-switching exercises.</p><p><strong>Results: </strong>During task-switching under methamphetamine cravings, the activation of the premotor cortex (PMC), supplementary motor area (SMA), frontal eye field (FEF), and dorsolateral prefrontal cortex (DLPFC) in women was significantly stronger than in men, while the activation of FEF in men was significantly stronger than in women. Voluntary task-switching induced stronger FEF activation than cued task-switching. During the latter, women exhibited stronger activation in the anterior prefrontal cortex (aPFC) than men.</p><p><strong>Discussion: </strong>Both men and women showed brain lateralization during task-switching under methamphetamine cravings. Men tended to adopt proactive control and use a top-down dominant strategy to start a new task. Women, however, tend to use a bottom-up strategy focusing on inhibiting old tasks and emotional switching. Moreover, in cued task-switching, the result shows women paid more attention to emotional processing than did men, which suggests that different task-switching training programs should be developed according to sex.</p>","PeriodicalId":12639,"journal":{"name":"Frontiers in Neuroscience","volume":null,"pages":null},"PeriodicalIF":3.2,"publicationDate":"2024-10-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11557557/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142618541","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Case report: Double mutations in a patient with early-onset Alzheimer's disease in China, PSEN2 and IDE variants.","authors":"Zhongzheng Chang, Zhiyang Wang, Lele Luo, Zhaohong Xie, Caibin Yue, Xianli Bian, Hui Yang, Ping Wang","doi":"10.3389/fnins.2024.1423892","DOIUrl":"10.3389/fnins.2024.1423892","url":null,"abstract":"<p><p>Alzheimer's disease (AD) is a progressive neurodegenerative disease characterized by gradual cognitive decline. Early-onset Alzheimer's disease (EOAD) is defined as AD occurring before age 65. The main pathogenic gene variants associated with EOAD include <i>PSEN1</i>, <i>PSEN2</i>, and <i>APP. IDE</i> gene has been identified as a risk factor in the pathogenesis of AD. In this study, we report a 33-year-old male with mutations in the <i>PSEN2</i> gene (c.640G > T, p.V214L) and <i>IDE</i> gene (c.782G > A, p.R261Q). <i>PSEN2</i> V214L has been reported in five previous cases, and no reported cases have carried <i>IDE</i> R261Q. He had progressive memory decline, his sister carried the same gene mutations but had no clinical manifestations. Neuroimaging revealed mild cortical atrophy. The concentration of Aβ42 in cerebrospinal fluid (CSF) was obviously decreased. In silico predictive models suggested that these mutations are damaging. Our findings indicate that mutations in the <i>PSEN2</i> and <i>IDE</i> genes may disrupt the normal functioning of their respective proteins, contributing to the pathogenesis of AD.</p>","PeriodicalId":12639,"journal":{"name":"Frontiers in Neuroscience","volume":null,"pages":null},"PeriodicalIF":3.2,"publicationDate":"2024-10-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11557526/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142618616","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Integrating subject-specific workspace constraint and performance-based control strategy in robot-assisted rehabilitation.","authors":"Qing Miao, Song Min, Cui Wang, Yi-Feng Chen","doi":"10.3389/fnins.2024.1473755","DOIUrl":"10.3389/fnins.2024.1473755","url":null,"abstract":"<p><strong>Introduction: </strong>The robot-assistive technique has been widely developed in the field of neurorehabilitation for enhancement of neuroplasticity, muscle activity, and training positivity. To improve the reliability and feasibility in this patient-robot interactive context, motion constraint methods and adaptive assistance strategies have been developed to guarantee the movement safety and promote the training effectiveness based on the user's movement information. Unfortunately, few works focus on customizing quantitative and appropriate workspace for each subject in passive/active training mode, and how to provide the precise assistance by considering movement constraints to improve human active participation should be further delved as well.</p><p><strong>Methods: </strong>This study proposes an integrated framework for robot-assisted upper-limb training. A human kinematic upper-limb model is built to achieve a quantitative human-robot interactive workspace, and an iterative learning-based repulsive force field is developed to balance the compliant degrees of movement freedom and constraint. On this basis, a radial basis function neural network (RBFNN)-based control structure is further explored to obtain appropriate robotic assistance. The proposed strategy was preliminarily validated for bilateral upper-limb training with an end-effector-based robotic system.</p><p><strong>Results: </strong>Experiments on healthy subjects are enrolled to validate the safety and feasibility of the proposed framework. The results show that the framework is capable of providing personalized movement workspace to guarantee safe and natural motion, and the RBFNN-based control structure can rapidly converge to the appropriate robotic assistance for individuals to efficiently complete various training tasks.</p><p><strong>Discussion: </strong>The integrated framework has the potential to improve outcomes in personalized movement constraint and optimized robotic assistance. Future studies are necessary to involve clinical application with a larger sample size of patients.</p>","PeriodicalId":12639,"journal":{"name":"Frontiers in Neuroscience","volume":null,"pages":null},"PeriodicalIF":3.2,"publicationDate":"2024-10-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11557535/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142618636","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Augmenting mindfulness training through neurofeedback: a pilot study of the pre-post changes on resting-state functional connectivity in typically developing adolescents.","authors":"Kelly T Cosgrove, Aki Tsuchiyagaito, Zsofia P Cohen, Gabe Cochran, Xiaoqian Yu, Masaya Misaki, Robin L Aupperle, Manpreet K Singh, Martin P Paulus, Namik Kirlic","doi":"10.3389/fnins.2024.1397234","DOIUrl":"10.3389/fnins.2024.1397234","url":null,"abstract":"<p><strong>Background: </strong>Mindfulness training has been shown to promote positive mental health outcomes and related changes in neural networks such as the default mode network, which has a central node in the posterior cingulate cortex (PCC). Previous work from our group reported on the impact of a novel, neurofeedback augmented mindfulness training (NAMT) task on regulation of PCC hemodynamic activity in typically developing adolescents. The present pilot study aimed to expand on this finding by examining the pre-post changes of the NAMT task on resting-state functional connectivity of the PCC.</p><p><strong>Methods: </strong>Thirty-one typically developing adolescents (14.77 ± 1.23 years; 45% female) underwent a resting-state functional magnetic resonance imaging scan both before and after completing the NAMT task. A linear mixed effects model was used to assess for changes in functional connectivity of the PCC across the two resting-state runs.</p><p><strong>Results: </strong>Data did not support the hypothesized decrease in connectivity between the PCC seed and other DMN regions from pre- to post-NAMT task. However, we observed a significant increase in functional connectivity between the PCC and a cluster encompassing the left hippocampus and amygdala following completion of the NAMT task (run 1 Fisher's <i>Z</i> = 0.16; run 2 Fisher's <i>Z</i> = 0.26).</p><p><strong>Conclusion: </strong>Although preliminary, this finding suggests NAMT has the potential to strengthen connectivity between default mode and salience regions. We speculate that such changed connectivity may facilitate enhanced self-referential and emotional processing in adolescents.</p><p><strong>Clinical trial registration: </strong>https://clinicaltrials.gov/, identifier NCT04053582.</p>","PeriodicalId":12639,"journal":{"name":"Frontiers in Neuroscience","volume":null,"pages":null},"PeriodicalIF":3.2,"publicationDate":"2024-10-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11558881/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142618608","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Corrigendum: Classification of autism spectrum disorder using electroencephalography in Chinese children: a cross- sectional retrospective study.","authors":"Si Yang Ke, Huiwen Wu, Haoqi Sun, Aiqin Zhou, Jianhua Liu, Xiaoyun Zheng, Kevin Liu, M Brandon Westover, Haiqing Xu, Xue-Jun Kong","doi":"10.3389/fnins.2024.1501782","DOIUrl":"https://doi.org/10.3389/fnins.2024.1501782","url":null,"abstract":"<p><p>[This corrects the article DOI: 10.3389/fnins.2024.1330556.].</p>","PeriodicalId":12639,"journal":{"name":"Frontiers in Neuroscience","volume":null,"pages":null},"PeriodicalIF":3.2,"publicationDate":"2024-10-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11555438/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142618618","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}