Frontiers in Neuroscience最新文献

{"title":"Executive function and neural oscillations in adults with attention-deficit/hyperactivity disorder: a systematic review.","authors":"Ziyao Su, Yingtan Wang, Bin Wang, Chuanliang Han, Haoran Zhang, Yanyan Gu, Yu Chen, Xixi Zhao, Yuwei Shi","doi":"10.3389/fnins.2025.1617307","DOIUrl":"10.3389/fnins.2025.1617307","url":null,"abstract":"<p><p>Attention-deficit/hyperactivity disorder (ADHD) is a childhood-onset neurobiological disorder that often persists into adulthood. Adult ADHD is an important public health concern due to its great social damage and challenges in clinical recognition, resulting in a significant disease burden. Nonetheless, the diagnosis of adult ADHD remains challenging due to the absence of specific symptoms and biological markers. The aims of this systematic review were as follows: (1) To discern whether there were any differences in resting-state electroencephalogram (EEG) and event related potential (ERP) between adult ADHD and healthy controls (HCs). (2) To ascertain whether ERP specific manifestations associated with executive function (EF) deficiencies. (3) To conduct an exploration into the mechanisms of specific electrophysiologic alterations. This review was conducted in PubMed-Medline and Web-of-Science from 1971 to August 15th, 2024 to summarize the EEG changes of adult ADHD. We focused on resting-state EEG to report spectral power across different frequency bands and ERPs under different experimental tasks, 68 studies were finally included. When studying the characteristics of resting-state EEG in adult ADHD patients, we observed that theta power exhibits a consistent upward trend. Congruous reduction Pe, P3, and N2 amplitudes during response inhibition tasks, with a further decrease in P3 and N2 amplitudes in sustained attention tasks. These EEG changes may stem from impairments in error detection, cognitive control, and attention allocation, meaning that core EFs are affected in adults with ADHD. Overall, consistent changes in resting-state EEG and ERPs could provide insight for the identification of ADHD in adults.</p>","PeriodicalId":12639,"journal":{"name":"Frontiers in Neuroscience","volume":"19 ","pages":"1617307"},"PeriodicalIF":3.2,"publicationDate":"2025-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12303959/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144741968","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prediction of apolipoprotein A-I and high-density lipoprotein cholesterol in the neurological impairment and relapse of neuromyelitis optica spectrum disorder.","authors":"Yanyan Wang, Feng Wang, Teng Huang, Ziling Zeng, Li Jiao, Hao Sun, Xiaoyu Zhang, Baojie Wang, Rujia Liu, Shougang Guo","doi":"10.3389/fnins.2025.1629357","DOIUrl":"10.3389/fnins.2025.1629357","url":null,"abstract":"<p><strong>Background and purpose: </strong>Neuromyelitis Optica Spectrum Disorder (NMOSD) is a rare inflammatory demyelinating disorder of the central nervous system, frequently resulting in irreversible neurological deficits such as blindness and paralysis. Emerging evidence suggests that dyslipidemia is associated with increased disability and poorer outcomes in autoimmune diseases. The purpose of the study is to investigate the associations between lipid profile with neurological impairment and relapse.</p><p><strong>Methods: </strong>This study retrospectively collected data from 130 hospitalized patients with AQP4-IgG positive NMOSD. Based on the Expanded Disability Status Scale (EDSS) scores at admission, patients were categorized into a mild-to-moderate group (EDSS ≤ 5.5) and a severe group (EDSS ≥ 6). All included patients were followed for at least 1 year, and were further divided into relapse and non-relapse groups based on whether a relapse occurred during the follow-up period. Logistic regression analysis was used to identify independent risk factors associated with the severity of neurological impairment and relapse. Receiver operating characteristic (ROC) curve analysis was conducted to determine the cutoff value of apolipoprotein A-I (ApoA-I) in predicting severe neurological impairment. Spearman correlation analysis was performed to assess the relationships among ApoA-I, high-density lipoprotein cholesterol (HDL-C) and CRP.</p><p><strong>Results: </strong>Multivariate binary logistic regression analysis revealed that ApoA-I (OR = 0.138, 95% CI: 0.021-0.902, <i>p</i> = 0.039) and the number of spinal cord lesion segments (OR = 1.368, 95% CI: 1.181-1.584, <i>p</i> < 0.001) were independent risk factors for the severity of neurological impairment. The area under the ROC curve (AUC) for ApoA-I in predicting the severity of neurological impairment was 0.647 (95% CI: 0.542-0.751), with a cutoff value of 1.165, a sensitivity of 59.4%, and a specificity of 67.6%. Multivariate logistic regression analysis identified HDL-C (OR = 0.082, 95% CI: 0.008-0.847, <i>p</i> = 0.036), clinical phenotype-specifically, compared to optic neuritis, myelitis (OR = 0.130, 95% CI: 0.037-0.458, <i>p</i> = 0.002), brainstem/cerebral syndrome (OR = 0.070, 95% CI: 0.007-0.731, <i>p</i> = 0.026), and mixed phenotypes (OR = 0.107, 95% CI: 0.018-0.642, <i>p</i> = 0.014) -as well as the use of subsequent monoclonal antibody therapy (OR = 0.190, 95% CI: 0.045-0.799, <i>p</i> = 0.023) as independent protective factors against relapse. Spearman correlation analysis showed that ApoA-I and HDL-C were significantly negatively correlated with CRP (<i>r</i> = -0.230, <i>p</i> = 0.008; <i>r</i> = -0.310, <i>p</i> < 0.001, respectively).</p><p><strong>Conclusion: </strong>Reduced levels of ApoA-I and HDL-C were associated with more severe neurological deficits and an increased risk of relapse.</p>","PeriodicalId":12639,"journal":{"name":"Frontiers in Neuroscience","volume":"19 ","pages":"1629357"},"PeriodicalIF":3.2,"publicationDate":"2025-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12303979/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144741971","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Homeostatic-related peptides injected into the rat nucleus accumbens alter palatable eating and impact the binge-like intake of a sweetened fat diet during simultaneous μ-opioid receptor stimulation.","authors":"Wayne E Pratt, Cardinal Do, Alexandra M Groome, Alana J Smith, Allison C Siegfried, Camryn J Calafiore","doi":"10.3389/fnins.2025.1614819","DOIUrl":"10.3389/fnins.2025.1614819","url":null,"abstract":"<p><strong>Background: </strong>The nucleus accumbens is central for directing motivated behavior and is a key node in the neural circuitry that promotes eating in response to palatable diets. We examined the impact of intra-accumbens injections of a variety of homeostatic-related peptides (HRPs) on eating elicited by a sweetened fat diet, with or without co-administration of the prophagic mu-opioid agonist [D-Ala2, N-MePhe4, Gly-ol]-enkephalin (DAMGO).</p><p><strong>Methods: </strong>Rats received surgical placement of guide cannulas above the anterior medial nucleus accumbens. Non-restricted animals were then accustomed to 2-h daily access to a sweetened fat diet. Palatable eating was examined following intra-accumbens injections of one hypothalamic HRP, alone or with co-infusions of DAMGO.</p><p><strong>Results: </strong>Nucleus accumbens injections of neuropeptide Y (NPY) and Orexin-A significantly increased palatable eating. Cocaine- and amphetamine-related transcript (CART) reduced intake. When rats received co-stimulation of μ-opioid receptors, NPY and DAMGO had a synergistic effect on food intake, whereas Orexin-A initially disrupted eating on the palatable diet and had no additive effect with DAMGO by the end of the session. Neither agouti-related protein (AGRP), melanin concentrating hormone (MCH), alpha-melanocyte stimulating hormone (αMSH), nor the stress-related peptides corticotropin-releasing factor (CRF) or urocortin impacted intake, although MCH and CRF both affected eating in response to mu-opioid receptor stimulation dependent upon the dose.</p><p><strong>Conclusion: </strong>These experiments offer insight into the regulation of hedonically motivated feeding by homeostatic- and stress-related inputs to the nucleus accumbens. This systematic examination suggests that the nucleus accumbens' role in promoting palatable eating is not independent of the homeostatic signals that reach it from the hypothalamus and other brain regions.</p>","PeriodicalId":12639,"journal":{"name":"Frontiers in Neuroscience","volume":"19 ","pages":"1614819"},"PeriodicalIF":3.2,"publicationDate":"2025-07-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12301393/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144729731","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Thalamic nuclei volumes are related to disease stage in patients with amyotrophic lateral sclerosis.","authors":"Tianrui Wen, Jun Zhu, Sujuan Sun, Yujing Chen, Ninglu Gao, Mingjie Ma, Xinyue Chen, Shuangwu Liu, Pengfei Lin, Yan Deng","doi":"10.3389/fnins.2025.1616239","DOIUrl":"10.3389/fnins.2025.1616239","url":null,"abstract":"<p><strong>Objective: </strong>To explore atrophy patterns in thalamic nuclei at different phases of amyotrophic lateral sclerosis (ALS) and determine any correlations between thalamic nucleus volume and either cognitive impairments or motor disabilities.</p><p><strong>Methods: </strong>We used the King's clinical staging system for ALS to divide 76 consecutive patients with ALS by disease stage. We investigated patterns of thalamic atrophy in the patients and in 94 healthy controls (HCs). Cognitive functions were evaluated with the Mini-Mental State Examination (MMSE), Frontal Assessment Battery, Boston Naming Test, and Auditory Verbal Learning Test.</p><p><strong>Results: </strong>Considering all ALS patients, no significant differences were observed in the volume of any thalamic nuclei between the ALS group and HCs. Thalamic nucleus volumes remained normal in ALS patients at King's Stage 2 and Stage 3. However, atrophy was detected in the bilateral anteroventral nucleus, bilateral pulvinar-limitans, bilateral mediodorsal-paratenial-reuniens, bilateral motor hub, bilateral sensory hub, and bilateral intralaminar nucleus in patients who had reached King's Stage 3. In these patients, the volume of the bilateral motor nuclei was associated with the revised ALS Functional Rating Scale scores, and that of the right pulvinar-limitans independently correlated with MMSE scores.</p><p><strong>Conclusion: </strong>Our study provides a comprehensive profile of thalamic atrophy in ALS patients. The thalamic atrophy patterns in these patients extremely differs at different King's Stages, and we suggest that these alterations might result largely from sequential, regional patterns of TDP-43 pathology in ALS. Furthermore, thalamic atrophy might play important roles in motor disability and global cognitive impairments observed in patients with ALS.</p>","PeriodicalId":12639,"journal":{"name":"Frontiers in Neuroscience","volume":"19 ","pages":"1616239"},"PeriodicalIF":3.2,"publicationDate":"2025-07-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12289602/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144729733","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"SVM-enhanced attention mechanisms for motor imagery EEG classification in brain-computer interfaces.","authors":"Zhenis Otarbay, Abzal Kyzyrkanov","doi":"10.3389/fnins.2025.1622847","DOIUrl":"10.3389/fnins.2025.1622847","url":null,"abstract":"<p><p>Brain-Computer Interfaces (BCIs) leverage brain signals to facilitate communication and control, particularly benefiting individuals with motor impairments. Motor imagery (MI)-based BCIs, utilizing non-invasive electroencephalography (EEG), face challenges due to high signal variability, noise, and class overlap. Deep learning architectures, such as CNNs and LSTMs, have improved EEG classification but still struggle to fully capture discriminative features for overlapping motor imagery classes. This study introduces a hybrid deep neural architecture that integrates Convolutional Neural Networks, Long Short-Term Memory networks, and a novel SVM-enhanced attention mechanism. The proposed method embeds the margin maximization objective of Support Vector Machines directly into the self-attention computation to improve interclass separability during feature learning. We evaluate our model on four benchmark datasets: Physionet, Weibo, BCI Competition IV 2a, and 2b, using a Leave-One-Subject-Out (LOSO) protocol to ensure robustness and generalizability. Results demonstrate consistent improvements in classification accuracy, F1-score, and sensitivity compared to conventional attention mechanisms and baseline CNN-LSTM models. Additionally, the model significantly reduces computational cost, supporting real-time BCI applications. Our findings highlight the potential of SVM-enhanced attention to improve EEG decoding performance by enforcing feature relevance and geometric class separability simultaneously.</p>","PeriodicalId":12639,"journal":{"name":"Frontiers in Neuroscience","volume":"19 ","pages":"1622847"},"PeriodicalIF":3.2,"publicationDate":"2025-07-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12289692/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144729732","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"EEG correlates of egocentric and altercentric biases in forensic cases with borderline personality.","authors":"Vincent Rochas, Marie-Louise Montandon, Cristelle Rodriguez, François R Herrmann, Ariel Eytan, Alan J Pegna, Christoph M Michel, Panteleimon Giannakopoulos","doi":"10.3389/fnins.2025.1583050","DOIUrl":"10.3389/fnins.2025.1583050","url":null,"abstract":"<p><p>People tend to consider others' perspective when judging their own (altercentric interference, AI) or other (egocentric interference, EI) divergent views. Borderline (BDL) and antisocial personalities are associated with significant changes in EI and AI. Combining the dot perspective-taking task with high-density EEG recordings, our study explores the correlations between EI and AI in cases with BDL diagnosis and court-ordered measures (BDL-COM; <i>n</i> = 14) compared to age-matched healthy controls (<i>n</i> = 24). In Inconsistent trials, controls displayed significant activation of brain generators, which was absent in BDL-COM patients. For the Self-Inconsistent stimuli (altercentric bias), controls showed increased activity in the left superior frontal gyrus between 58 and 74 ms and the left inferior frontal gyrus between 279 and 303 ms. Similar differences were observed for Other-Inconsistent stimuli (egocentric bias) in the precentral gyri and inferior frontal gyrus between 274 and 296 ms. These findings suggest that AI involves an early activation of brain generators in central executive and mentalizing areas. EI is associated with an increased activation of the mirror neuron system based on self-other distinction. These EEG data indicate that BDL-COM patients display significant difficulties activating all of the brain generators involved in the processing of conflicting viewpoints in visual perspective-taking.</p>","PeriodicalId":12639,"journal":{"name":"Frontiers in Neuroscience","volume":"19 ","pages":"1583050"},"PeriodicalIF":3.2,"publicationDate":"2025-07-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12287005/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144707319","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hemodynamic analysis of non-stenotic middle cerebral artery in patients with cerebral ischemia based on 4D flow MRI.","authors":"Yue Chen, Jiali Sun, Ying Sui, Ying Shi, Jianxiu Lian, Ping Yang, Shuai Lin, Min Lyu, Na Li, Tong Zhang, Wei Wang","doi":"10.3389/fnins.2025.1502987","DOIUrl":"10.3389/fnins.2025.1502987","url":null,"abstract":"<p><strong>Objectives: </strong>Changes in cerebral hemodynamics in symptomatic states among patients with cerebral ischemia remain unclear. This study endeavors to investigate the characteristics of hemodynamics distribution within the non-stenotic middle cerebral artery (MCA) in patients with anterior circulation cerebral ischemia.</p><p><strong>Materials and methods: </strong>All subjects were prospectively recruited in this study. According to the clinical features of cerebral ischemia symptoms, they were divided into ischemia group and healthy group. MCA was further divided into proximal, curved, and distal segments based on the vascular morphology. Hemodynamic parameters, including flow, peak flow velocity, wall shear stress (WSS), pressure and energy loss (EL) were measured for each segment of the MCA in both groups using 4D flow MRI. The hemodynamic parameters of the proximal, curved, and distal MCA segments were compared within the group, and the influence of MCA morphology on hemodynamics was analyzed. Additionally, the hemodynamic parameters of the proximal, curved, and distal MCA segments were compared between the healthy and the ischemic groups to analyze the hemodynamic changes in the MCA among patients with cerebral ischemia.</p><p><strong>Results: </strong>A total of 50 MCAs were included in healthy group and 30 MCAs in ischemia group. There were no statistically significant differences in gender, age, heart rate, presence of hypertension and Body mass index (BMI) between the two groups. Results showed that the proximal segment had the highest blood volume (all <i>P</i> < 0.05), the M1 segment of MCA had the highest pressure (Max) and EL (Max and Avg) (all <i>P</i> < 0.01) in both groups. The peak blood flow velocity of the proximal and curved segments, the circumferential WSS of the distal segment, and the EL (Max and Avg) of the M1 segment in the ischemia group were lower than those in the healthy group (all <i>P</i> < 0.05).</p><p><strong>Conclusion: </strong>The distribution of hemodynamics in MCA is similar between anterior circulation cerebral ischemia patients and healthy group. In the ischemic group, the peak blood flow velocity, circumferential WSS, and EL of MCA were lower compared to the healthy group. The reduced flow velocity and the decrease of circumferential WSS in the curved section may be contributing factors to cerebrovascular events.</p>","PeriodicalId":12639,"journal":{"name":"Frontiers in Neuroscience","volume":"19 ","pages":"1502987"},"PeriodicalIF":3.2,"publicationDate":"2025-07-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12287126/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144707321","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bibliometric and visualization analysis of hydrogel research in spinal cord injury: comparative study of Chinese and English literature.","authors":"Wenju Bai, Xiaoyuan Huang, Jian Liu, Kamiran Halike, Jinyong Li, Xv Zhang, Tengwu Chang, Jichao Wang","doi":"10.3389/fnins.2025.1636904","DOIUrl":"10.3389/fnins.2025.1636904","url":null,"abstract":"<p><strong>Background: </strong>Over the past decade, the fields of hydrogel and spinal cord injury (SCI) research have witnessed rapid development. To explore disparities between China and global trends in hydrogel research, this study systematically conducted qualitative and quantitative analyses of related publications, summarizing current research foci and future directions. This provides critical guidance for researchers to delve deeper into hydrogel applications.</p><p><strong>Methods: </strong>A total of 866 records in the hydrogel and SCI domains were collected from the Web of Science Core Collection (WoSCC) and China National Knowledge Infrastructure (CNKI) between 2014 and 2024. CiteSpace, VOSviewer, SCImago, and the R package \"bibliometrix\" were utilized to analyze regional distributions, institutional collaborations, journal impacts, author productivity, and keyword trends.</p><p><strong>Results: </strong>Annual publications in hydrogel and SCI research exhibited consistent growth. China (<i>n</i> = 382) and the United States (<i>n</i> = 158) collectively contributed 76.2% of global academic output, reflecting disproportionate productivity. Zhejiang University and Jinan University demonstrated significant contributions across international and Chinese academic platforms. XIAO Jian distinguished himself through exceptional metrics (h-index, total citations), establishing his prominence as a high-impact scholar. BIOMATERIALS emerged as the most prolific and influential journal based on total link strength. Keyword and co-citation analyses revealed heightened emphasis on 3D bioprinting and electroactive bio-scaffolds in both WoSCC and CNKI databases. Systemic research disparities reveals that CNKI prioritize hydrogel technologies with a distinctive focus on indigenous specializations (e.g., Chuanxiongzine and stem cell transplantation), while WoSCC demonstrates notable advantages in establishing therapeutic loops encompassing drug delivery systems, functional recovery evaluation, and neuroimmune modulation strategies.</p><p><strong>Conclusion: </strong>By integrating WoSCC and CNKI data, this study comprehensively elucidates geographical disparities in research priorities between China and the global scientific community regarding hydrogel-mediated SCI repair, thereby proposing an evidence-based framework for international collaborative innovation. These insights offer valuable references to guide future hydrogel research.</p>","PeriodicalId":12639,"journal":{"name":"Frontiers in Neuroscience","volume":"19 ","pages":"1636904"},"PeriodicalIF":3.2,"publicationDate":"2025-07-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12287083/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144707303","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Gut microbiota and stress ulcers: unraveling the neurotransmitter connection.","authors":"Khaled A Abdel-Sater, Heba A Hassan","doi":"10.3389/fnins.2025.1594179","DOIUrl":"10.3389/fnins.2025.1594179","url":null,"abstract":"<p><strong>Background: </strong>Neurotransmitters are key signaling molecules in the brain-gut axis, may be involved in stress-induced ulcer damage.</p><p><strong>Objective: </strong>This study aims to address the relationship between gut microbiota and the stress response is examined in this review, with a focus on how neurotransmitters moderate the impact of stress on mucosal integrity and gut health. Understanding these mechanisms may open new avenues for therapeutic interventions targeting the brain-gut axis.</p><p><strong>Methods: </strong>A literature search was completed using PubMed, Web of Science, Cochrane, PsycINFO, Scopus and Embase databases for clinical and preclinical studies related to stress ulcer, gut microbiota and gut brain axis that published in English until November 2024.</p><p><strong>Results: </strong>The gut microbiota plays important role in preserving the health of the digestive system and influencing the body's stress response through various pathways, including the enteric and autonomic nervous systems. This results in the production of microbial metabolites such as bile acids, tryptophan, and short-chain fatty acids that enter the bloodstream and go to the brain. Microbial neurotransmitters change the brain's gastrointestinal axis.</p><p><strong>Conclusion: </strong>The connection between stress ulcer, neurotransmitters, and the gut microbiota was outlined in this review.</p>","PeriodicalId":12639,"journal":{"name":"Frontiers in Neuroscience","volume":"19 ","pages":"1594179"},"PeriodicalIF":3.2,"publicationDate":"2025-07-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12286954/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144707320","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Optimized workflow for behavior-coupled fiber photometry experiment: improved data navigation and accessibility.","authors":"Anna Athanassi, Amaury François, Emmanuel Bourinet, Marc Thevenet, Nathalie Mandairon","doi":"10.3389/fnins.2025.1601127","DOIUrl":"10.3389/fnins.2025.1601127","url":null,"abstract":"<p><p>Fiber photometry provides crucial insights into cell population activity underlying behavior. While numerous open-source data analysis tools exist, few offer an automated workflow that streamlines the analysis of fiber photometry data alongside behavioral measurements, by enabling more intuitive and facilitated navigation within data files. We developed here a workflow starting from the intracerebral implantation of optical fibers in mice, to the analysis of fiber photometry signals, aligned with recorded behavioral data. This tool is particularly valuable for studying unpredictable exploratory behaviors, as it allows efficient and rapid revisiting of fiber photometry signals aligned to spontaneous behavioral changes. Our approach allows ease of data analysis and exploration using custom algorithms and scripts that extract and process both fiber photometry and behavioral data, without relying on predefined event markers. We validated our method by assessing calcium activity and dopaminergic dynamics in the olfactory tubercle in response to spontaneous investigation of attractive and non-attractive odorants in freely moving adult C57BL/ 6J mice. Using jRGECO1a and dLight1.2 biosensors, we revealed distinct dopamine responses to attractive versus unattractive odorants while calcium transmission remained similar. Overall, our method significantly enhances the accessibility and efficiency of data analysis, allowing for rapid retrieval and exploration of key behavioral time points. Its adaptability makes it suitable for a wide range of spontaneous behaviors, paradigms, and sensory modalities, facilitating deeper insights into complex neural dynamics.</p>","PeriodicalId":12639,"journal":{"name":"Frontiers in Neuroscience","volume":"19 ","pages":"1601127"},"PeriodicalIF":3.2,"publicationDate":"2025-07-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12287066/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144707322","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}