Frontiers in Neuroscience最新文献

{"title":"How learning to read Braille in visual and tactile domains reorganizes the sighted brain.","authors":"Maciej Gaca, Alicja M Olszewska, Dawid Droździel, Agnieszka Kulesza, Małgorzata Paplińska, Bartosz Kossowski, Katarzyna Jednoróg, Jacek Matuszewski, Aleksandra M Herman, Artur Marchewka","doi":"10.3389/fnins.2024.1297344","DOIUrl":"10.3389/fnins.2024.1297344","url":null,"abstract":"<p><p>Learning tactile Braille reading leverages cross-modal plasticity, emphasizing the brain's ability to reallocate functions across sensory domains. This neuroplasticity engages motor and somatosensory areas and reaches language and cognitive centers like the visual word form area (VWFA), even in sighted subjects following training. No study has employed a complex reading task to monitor neural activity during the first weeks of Braille training. Since neuroplasticity can occur within days, understanding neural reorganization during early learning stages is critical. Moreover, such activation was not tested in visual and tactile domains using comparable tasks. Furthermore, implicit reading has not been studied in tactile Braille. Although visual reading in the native script occurs automatically, it remains uncertain whether the same applies to tactile reading. An implicit reading task could extend the knowledge of linguistic processing in Braille. Our study involved 17 sighted adults who learned Braille for 7 months and 19 controls. The experimental group participated in 7 testing sessions (1 week before the course, on the first day, after 1 and 6 weeks, after 3 and 7 months, and after 3 month-long hiatus). Using the fMRI Lexical Decision Task, we observed increased activity within the reading network, including the inferior frontal and supramarginal gyri, 1 week into learning in tactile and visual Braille. Interestingly, VWFA activation was observed after 1 week in the visual domain but only after 6 weeks in the tactile domain. This suggests that skill level in tactile reading influences the onset of involvement of VWFA. Once this activation was achieved, the peak level of VWFA engagement remained stable, even after the follow-up. Furthermore, an implicit reading task revealed increased activity within the reading network, including the VWFA, among participants learning Braille compared to the passive controls. Possibly, implicit reading occurs during non-reading tactile tasks where the Braille alphabet is present. We showed that the VWFA activity peak occurs faster in the visual domain compared to the tactile domain. We also showed that sighted subjects can process tactile Braille implicitly. These results enrich our understanding of neural adaptation mechanisms and the interplay between sensory modalities during complex, cross-modal learning.</p>","PeriodicalId":12639,"journal":{"name":"Frontiers in Neuroscience","volume":"18 ","pages":"1297344"},"PeriodicalIF":3.2,"publicationDate":"2025-01-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11744719/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143004158","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Alternations of interhemispheric functional connectivity in patients with acute acquired concomitant esotropia: a resting state fMRI study using voxel-mirrored homotopic connectivity.","authors":"Jiayu Chen, Jie Hao, Jiawen Liu, Huijian Li, Zhaojun Meng, Jing Fu","doi":"10.3389/fnins.2024.1515675","DOIUrl":"https://doi.org/10.3389/fnins.2024.1515675","url":null,"abstract":"<p><strong>Purpose: </strong>To investigate the changes in cerebral hemispheric functional connections in patients with acute acquired concomitant esotropia (AACE) and their relationship with clinical manifestations, utilizing voxel-mirrored homotopic connectivity (VMHC).</p><p><strong>Methods: </strong>A prospective, observational study was conducted involving 32 AACE patients and 31 age-, sex-, and education-matched healthy controls (HC). The resting-state functional magnetic resonance imaging (rs-fMRI) signals, binocular vision function, and psychometric scale scores were collected rs-fMRI data and structural image data were analyzed for VMHC, and a two-sample <i>t</i>-test was used to analyze the differences in VMHC between groups. Spearman correlation analysis evaluated the relationship between fMRI indicators and clinical features.</p><p><strong>Results: </strong>There was no statistical difference between the two groups concerning sex, age, height and weight. VMHC levels in the superior frontal gyrus and anterior cingulate were significantly lower in the AACE group (<i>p</i> < 0.05). In the AACE group, the VMHC values of the left caudate positively correlated with near vision work duration (<i>r</i> = 0.381, <i>p</i> = 0.034), the deviation angles at near (<i>r</i> = 0.428, <i>p</i> = 0.015) and at distance (<i>r</i> = 0.416, <i>p</i> = 0.018). The VMHC values in the bilateral olfactory cortex also positively correlated with the near vision work duration (Right: <i>r</i> = 0.389, <i>p</i> = 0.031; Left: <i>r</i> = 0.372, <i>p</i> = 0.039) while Beck Depression Inventory (BDI) scores negatively correlated with the VMHC values of the left olfactory cortex (<i>r</i> = -0.359, <i>p</i> = 0.048).</p><p><strong>Conclusion: </strong>The dysfunction of the medial frontal gyrus and anterior cingulate gyrus is the underlying neuropathological mechanism of AACE, and these dysfunctions may be related to poor eye habits and the severity of deviation.</p>","PeriodicalId":12639,"journal":{"name":"Frontiers in Neuroscience","volume":"18 ","pages":"1515675"},"PeriodicalIF":3.2,"publicationDate":"2025-01-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11743661/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143003956","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Local abnormal white matter microstructure in the spinothalamic tract in people with chronic neck and shoulder pain.","authors":"Zhiqiang Qiu, Tianci Liu, Chengxi Zeng, Maojiang Yang, Xiaoxue Xu","doi":"10.3389/fnins.2024.1485045","DOIUrl":"https://doi.org/10.3389/fnins.2024.1485045","url":null,"abstract":"<p><strong>Objective: </strong>To investigate differences in the microstructure of the spinothalamic tract (STT) white matter in people with chronic neck and shoulder pain (CNSP) using diffusion tensor imaging, and to assess its correlation with pain intensity and duration of the pain.</p><p><strong>Materials and methods: </strong>A 3.0T MRI scanner was used to perform diffusion tensor imaging scans on 31 people with CNSP and 24 healthy controls (HCs), employing the Automatic Fiber Segmentation and Quantification (AFQ) method to extract the STT and quantitatively analyze the fractional anisotropy (FA) and mean diffusivity (MD), reflecting the microstructural integrity of nerve fibers. Correlations of these differences with duration of pain and visual analog scale (VAS) scores were analyzed.</p><p><strong>Results: </strong>No significant differences in the mean FA or MD values of the bilateral STT were observed between people with CNSP and HCs (<i>p</i> > 0.05), as indicated by the two-sample t test. Further point-by-point comparison along 100 equidistant nodes within the STT pathway revealed significant reductions in FA values in the left (segments 12-18, 81-89) and right (segments 9-19, 76-80) STT in the CNSP group compared to HCs; significant increases in MD values were observed in the left (segments 1-13, 26-30, 71-91) and right (segments 8-17, 76-91) STT (<i>p</i> < 0.05, FWE corrected). Partial correlation analysis indicates that in people with CNSP, the FA values of the STT in regions with damaged white matter structure show a negative correlation with VAS scores and duration of pain, whereas MD values show a positive correlation with VAS scores and duration of pain.</p><p><strong>Conclusion: </strong>This study found that people with CNSP exhibit white matter microstructural abnormalities in the specific segments of STT. These abnormalities are associated with the patient's pain intensity and disease duration. The findings offer a new neuroimaging perspective on the pathophysiological basis of chronic pain in the ascending conduction process and its potential role in developing targeted intervention strategies. However, due to the limited sample size and the lack of statistical significance when analyzing the entire spinothalamic tract, these conclusions should be interpreted with caution. Further research with larger cohorts is necessary to validate these results.</p>","PeriodicalId":12639,"journal":{"name":"Frontiers in Neuroscience","volume":"18 ","pages":"1485045"},"PeriodicalIF":3.2,"publicationDate":"2025-01-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11743484/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143004248","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A time for sex: circadian regulation of mammalian sexual and reproductive function.","authors":"Sydney Aten, Oscar Ramirez-Plascencia, Chiara Blake, Gabriel Holder, Emma Fishbein, Adam Vieth, Arman Zarghani-Shiraz, Evan Keister, Shivani Howe, Ashley Appo, Beatrice Palmer, Carrie E Mahoney","doi":"10.3389/fnins.2024.1516767","DOIUrl":"10.3389/fnins.2024.1516767","url":null,"abstract":"<p><p>The circadian clock regulates physiological and biochemical processes in nearly every species. Sexual and reproductive behaviors are two processes controlled by the circadian timing system. Evidence supporting the importance of proper clock function on fertility comes from several lines of work demonstrating that misalignment of biological rhythms or disrupted function of the body's master clock, such as occurs from repeated shift work or chronic jet lag, negatively impacts reproduction by interfering with both male and female fertility. Along these lines, dysregulation of clock genes leads to impairments in fertility within mammals, and disruption of circadian clock timing negatively impacts sex hormone levels and semen quality in males, and it leads to ovulatory deficiencies in females. Here, we review the current understanding of the circadian modulation of both male and female reproductive hormones-from animal models to humans. Further, we discuss neural circuits within the hypothalamus that may regulate circadian changes in mammalian sexual behavior and reproduction, and we explore how knowledge of such circuits in animal models may help to improve human sexual function, fertility, and reproduction.</p>","PeriodicalId":12639,"journal":{"name":"Frontiers in Neuroscience","volume":"18 ","pages":"1516767"},"PeriodicalIF":3.2,"publicationDate":"2025-01-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11743455/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143004030","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"NORDIC denoising on VASO data.","authors":"Lasse Knudsen, Luca Vizioli, Federico De Martino, Lonike K Faes, Daniel A Handwerker, Steen Moeller, Peter A Bandettini, Laurentius Huber","doi":"10.3389/fnins.2024.1499762","DOIUrl":"10.3389/fnins.2024.1499762","url":null,"abstract":"<p><p>The use of submillimeter resolution functional magnetic resonance imaging (fMRI) is increasing in popularity due to the prospect of studying human brain activation non-invasively at the scale of cortical layers and columns. This method, known as laminar fMRI, is inherently signal-to-noise ratio (SNR)-limited, especially at lower field strengths, with the dominant noise source being of thermal origin. Furthermore, laminar fMRI is challenged with signal displacements due to draining vein effects in conventional gradient-echo blood oxygen level-dependent (BOLD) imaging contrasts. fMRI contrasts such as cerebral blood volume (CBV)-sensitive vascular space occupancy (VASO) sequences have the potential to mitigate draining vein effects. However, VASO comes along with another reduction in detection sensitivity. NOise Reduction with DIstribution Corrected (NORDIC) PCA (principal component analysis) is a denoising technique specifically aimed at suppressing thermal noise, which has proven useful for increasing the SNR of high-resolution functional data. While NORDIC has been examined for BOLD acquisitions, its application to VASO data has been limited, which was the focus of the present study. We present a preliminary analysis to evaluate NORDIC's capability to suppress thermal noise while preserving the VASO signal across a wide parameter space at 3T. For the data presented here, with a proper set of parameters, NORDIC reduced thermal noise with minimal bias on the underlying signal and preserved spatial resolution. Denoising performance was found to vary with different implementation strategies and parameter choices, for which we provide recommendations. We conclude that when applied properly, NORDIC has the potential to overcome the sensitivity limitations of laminar-specific VASO fMRI. Since very few groups currently have 3T VASO data, by sharing our analysis and code, we can compile and compare the effects of NORDIC across a broader range of acquisition parameters and study designs. Such a communal effort will help develop robust recommendations that will increase the utility of laminar fMRI at lower field strengths.</p>","PeriodicalId":12639,"journal":{"name":"Frontiers in Neuroscience","volume":"18 ","pages":"1499762"},"PeriodicalIF":3.2,"publicationDate":"2025-01-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11743533/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143004252","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Feasibility and potential diagnostic value of [¹⁸F]PI-2620 PET in patients with down syndrome and Alzheimer's disease: a case series.","authors":"Olivia Wagemann, Matthias Brendel, Nicolai Franzmeier, Georg Nübling, Johannes Gnörich, Mirlind Zaganjori, Catharina Prix, Anna Stockbauer, Elisabeth Wlasich, Sandra V Loosli, Katja Sandkühler, Lukas Frontzkowski, Günter Höglinger, Johannes Levin","doi":"10.3389/fnins.2024.1505999","DOIUrl":"10.3389/fnins.2024.1505999","url":null,"abstract":"<p><strong>Purpose of the report: </strong>Adults with Down Syndrome (DS) have a substantially increased risk for Alzheimer's disease (AD) due to the triplicated amyloid-precursor-protein gene on chromosome 21, resulting in amyloid and tau accumulation. However, tau PET assessments are not sufficiently implemented in DS-AD research or clinical work-up, and second-generation tau tracers such as [¹⁸F]PI-2620 have not been thoroughly characterized in adults with DS. We aim at illustrating feasibility and potential diagnostic value of tau PET imaging with [¹⁸F]PI-2620 for the diagnosis of DS-AD.</p><p><strong>Materials and methods: </strong>Five adults with DS (40% female, aged 43-62) and cognitive decline underwent clinical assessments, neuropsychological testing, lumbar puncture and multimodal neuroimaging. All underwent [¹⁸F]PI-2620 tau PET. Visual read of tau PET scans was performed by three blinded raters, assessing increased tracer uptake in brain areas corresponding to the six Braak stage regions and basal ganglia.</p><p><strong>Results: </strong>Visual read of tau burden revealed three tau-positive individuals which corresponded to their clinical decline while two cognitively stable individuals were rated as negative. Rating showed high inter-rater reliability for all Braak stages.</p><p><strong>Conclusion: </strong>Tau PET imaging is a feasible and important biomarker assessment in the differential diagnosis of cognitive decline in adults with DS at risk of developing AD.</p>","PeriodicalId":12639,"journal":{"name":"Frontiers in Neuroscience","volume":"18 ","pages":"1505999"},"PeriodicalIF":3.2,"publicationDate":"2025-01-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11744071/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143004140","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparative efficacy of neuroprotective agents for improving neurological function and prognosis in acute ischemic stroke: a network meta-analysis.","authors":"Yuchen Wang, Mengqi Li, Yuye Jiang, Qiuhong Ji","doi":"10.3389/fnins.2024.1530987","DOIUrl":"10.3389/fnins.2024.1530987","url":null,"abstract":"<p><strong>Background: </strong>Ischemic stroke is the second leading cause of death and the third leading cause of combined disability and mortality globally. While reperfusion therapies play a critical role in the management of acute ischemic stroke (AIS), their applicability is limited, leaving many patients with significant neurological deficits and poor prognoses. Neuroprotective agents have garnered attention for their potential as adjunct therapies; however, their relative efficacy remains unclear. This study utilized a network meta-analysis (NMA) to systematically compare the efficacy of neuroprotective agents in improving neurological function and prognosis in stroke patients.</p><p><strong>Methods: </strong>This study adhered to PRISMA guidelines and the Cochrane Handbook for systematic reviews. Randomized controlled trials (RCTs) were identified through comprehensive searches of the PubMed, Embase, and Cochrane Library databases. Two independent reviewers conducted the selection process, data extraction, and quality assessment. Outcomes included 90-day modified Rankin Scale (90d-mRS), change of National Institutes of Health Stroke Scale score from baseline to 90-day/14-day/7-day (90d/14d/7d-NIHSS) and 90-day/14-day Barthel Index (90d/14d-BI). Data analyses were performed using RevMan 5.4 and Stata 14.0.</p><p><strong>Results: </strong>A total of 42 RCTs involving 12,210 participants were included in this analysis. The interventions assessed included Cerebrolysin, Citicoline, Edaravone, Edaravone Dextranol, Human urinary kallidinogenase, Minocycline, Nerinetide, Butylphthalide, Vinpocetine, and Control. The NMA results demonstrated that NBP ranked highest for the 90d-mRS, 90d-NIHSS, 14d-NIHSS, and 14d-BI outcomes. Edaravone was found to be the most effective intervention for the 7d-NIHSS and 90d-BI outcomes.</p><p><strong>Conclusion: </strong>The findings of this study indicate that different neuroprotective agents exhibit distinct advantages at specific stages of recovery. NBP showed outstanding performance in improving 90d-mRS and 90d-NIHSS, underscoring its potential in long-term rehabilitation. Edaravone demonstrated significant superiority in 7d-NIHSS scores, highlighting its role in early neuroprotection. These results provide valuable insights for individualized clinical treatment. To further validate the efficacy and safety of neuroprotective agents, future studies should involve larger sample sizes and conduct multicenter, large-scale randomized controlled trials.</p><p><strong>Systematic review registration: </strong>https://www.crd.york.ac.uk/prospero/display_record.php?RecordID=601346, identifier CRD42024601346.</p>","PeriodicalId":12639,"journal":{"name":"Frontiers in Neuroscience","volume":"18 ","pages":"1530987"},"PeriodicalIF":3.2,"publicationDate":"2025-01-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11743486/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143004063","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"What a NeuroRights legislation should not look like: the case of the Latin American Parliament.","authors":"Diego Borbón","doi":"10.3389/fnins.2024.1514338","DOIUrl":"https://doi.org/10.3389/fnins.2024.1514338","url":null,"abstract":"","PeriodicalId":12639,"journal":{"name":"Frontiers in Neuroscience","volume":"18 ","pages":"1514338"},"PeriodicalIF":3.2,"publicationDate":"2025-01-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11739119/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143004323","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Postoperative evaluation of visual and cognitive functions following cataract surgery in patients with age-related cataracts: a prospective longitudinal study.","authors":"Chenzhu Zhao, Xuan Li, Bolin Deng, Bingyue Shui, Lin Zhou, Zhengzheng Wu","doi":"10.3389/fnins.2024.1505585","DOIUrl":"https://doi.org/10.3389/fnins.2024.1505585","url":null,"abstract":"<p><strong>Introduction: </strong>Cataracts are associated with a decline in both cognitive and visual functions. This study examines postoperative changes in cognitive and visual functions in patients with age-related cataracts, focusing on the differential effects of unilateral and bilateral cataract surgeries on these functions. Additionally, the study evaluates changes in cognitive function following cataract surgery in individuals with mild cognitive impairment (MCI).</p><p><strong>Methods: </strong>A cohort of patients (n = 35, 59 eyes) aged 60 years and older (69.9 ± 7.0 years) with age-related cataracts who underwent unilateral or bilateral cataract surgery between May and June 2024 was selected. Cognitive and visual functions were evaluated preoperatively and at 1 week, 1 month, and 3 months postoperatively. Cognitive function was evaluated using the Montreal Cognitive Assessment (MoCA). Visual function was assessed using a binocular visual function testing system based on virtual reality (VR) technology, which evaluated low spatial frequency suppression, simultaneous vision, stereopsis, and perceptual eye position under 3D viewing conditions without glasses. Based on preoperative MoCA scores, patients were classified into cognitively normal and mild cognitive impairment (MCI) groups.</p><p><strong>Results: </strong>Patients with age-related cataracts demonstrated significant improvements in both cognitive and visual functions at 1 week, 1 month, and 3 months postoperatively, compared to preoperative assessments (<i>p</i> < 0.05). Specifically, both the bilateral surgery group and the MCI group exhibited substantial improvements in cognitive function at these time points (<i>p</i> < 0.05). Additionally, the bilateral surgery group outperformed the unilateral surgery group in cognitive function throughout the follow-up period (<i>p</i> < 0.05). In terms of visual function, the bilateral surgery group showed significant improvements in low spatial frequency suppression, simultaneous vision, and stereopsis at 1 week, 1 month, and 3 months postoperatively, compared to preoperative measurements (<i>p</i> < 0.05).</p><p><strong>Conclusion: </strong>Both cognitive and visual functions significantly improved after cataract surgery. Bilateral cataract surgery is more effective in increasing the cognitive functions than unilateral surgery. Additionally, cataract surgery plays a critical role in facilitating cognitive recovery in patients with mild cognitive impairment (MCI).</p>","PeriodicalId":12639,"journal":{"name":"Frontiers in Neuroscience","volume":"18 ","pages":"1505585"},"PeriodicalIF":3.2,"publicationDate":"2025-01-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11739296/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143004268","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Aesthetic evaluation underpinning brand love relationship development: an activation likelihood estimation meta-analysis and multivariate analysis.","authors":"Shinya Watanuki","doi":"10.3389/fnins.2024.1443578","DOIUrl":"10.3389/fnins.2024.1443578","url":null,"abstract":"<p><strong>Objectives: </strong>Brand love is a crucial construct in marketing strategies. Building brand love can generate stable profits for enterprises. Although the marketing literature points out that aesthetic factors contribute to establishing the relationship as a trigger, to what stage of the relationship do they influence the minds of consumers? The present study attempts to reveal the involvement of aesthetic experiences in brand love developmental dynamics.</p><p><strong>Methodology: </strong>Using the activation likelihood estimation method, we address this issue by assessing overlapping brain regions between brand love at each stage and aesthetic experiences. We adopted three major meta-analytic decoding analysis modules to objectively interpret these brain regions, namely, Neurosynth, NeuroQuery, and the Behavioral Analysis plugin (BrainMap platform). Moreover, we performed a correspondence analysis to identify relationships of mental processes between aesthetic experiences and brand love in each developmental stage of brand love.</p><p><strong>Findings: </strong>Our results suggest that the same neural mechanism and mental processes may be underlaid between brand love and aesthetic experiences across all stages. Although reward- and emotion-related mental processes are commonly underlaid between brand love at the first-half stage and aesthetic experiences, exteroceptive and interoceptive signals may drive those mental processes between the early and migration stages of brand love, respectively, and aesthetic experiences. Overlapping regions of brand love at the stable stage and aesthetic experiences may be associated with semantic processing.</p><p><strong>Conclusion: </strong>We demonstrate that several brain regions overlapped between brand love and aesthetic experiences across all the brand love developmental stages. Therefore, aesthetic experiences might be associated with the mental processes of brand love development through all the developmental stages. Our results suggest that aesthetic experiences are essential elements for developing brand-love relationships.</p><p><strong>Implications: </strong>Our findings indicate that marketers should recognize that aesthetic experiences play a crucial role in building a bond between brands and consumers, not only when choosing brands. Thus, marketers need to design visual strategies from the view of nurturing brand-love relationships.</p>","PeriodicalId":12639,"journal":{"name":"Frontiers in Neuroscience","volume":"18 ","pages":"1443578"},"PeriodicalIF":3.2,"publicationDate":"2025-01-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11739102/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143004033","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}