Frontiers in NeurosciencePub Date : 2025-01-30eCollection Date: 2025-01-01DOI: 10.3389/fnins.2025.1489049
Zhongke Wang, Lu Chen, Tianyu Jiang, Qi Zhang, Jinying Zhao, Fuchun Wang
{"title":"Research status and trends of functional magnetic resonance imaging technology in the field of acupuncture: a bibliometric analysis over the past two decades.","authors":"Zhongke Wang, Lu Chen, Tianyu Jiang, Qi Zhang, Jinying Zhao, Fuchun Wang","doi":"10.3389/fnins.2025.1489049","DOIUrl":"https://doi.org/10.3389/fnins.2025.1489049","url":null,"abstract":"<p><strong>Objective: </strong>Although fMRI has been widely used in the field of acupuncture. However, the literature analysis in this field still has significant differences. This study summarizes the current status of functional magnetic resonance imaging (fMRI) in the field of acupuncture and moxibustion and predicts its future trends through Web of Science bibliometric analysis.</p><p><strong>Methods: </strong>This study uses \"fMRI\" and \"acupuncture\" as keywords to search for literature related to functional magnetic resonance imaging (fMRI) in acupuncture research in the Web of Science Core Collection database from January 1, 2004, to April 30, 2024. Visualization analyses were conducted using Citespace (version 6.3 R1) and VOSviewer (version 1.6.20). Citespace was employed to analyze annual publications, countries, institutions, keywords, and co-cited references. VOSviewer was used to analyze authors and co-cited authors, as well as journals and co-cited journals.</p><p><strong>Results: </strong>From 2004 to 2024, a total of 967 publications were retrieved, of which 557 were included after screening. Despite annual fluctuations, the overall trend shows an increase. China and the Chinese Academy of Sciences are the countries and institutions with the highest number of publications, with Tian, J being the author with the most publications, and Kong, J having the highest Co-citation frequency. The article by Dhond, RP, published in 2008, has the highest Co-citation frequency among the co-cited literature. Evidence-based Complementary and Alternative Medicine is the journal with the most publications, while Neuroimage is the co-cited journal with the highest citation frequency. Keyword co-occurrence and burst reveal the main research hotspots, including the diversity of intervention methods, cortical activation, mechanisms related to pain-associated diseases, and brain-related diseases. Keyword burst detection reflects emerging trends, including meta-analysis and systematic reviews, the relationship between ischemic stroke and women, and the connection between mild cognitive impairment and prevention.</p><p><strong>Conclusion: </strong>This study employs bibliometric methods to explore the current status, research hotspots, and frontier issues regarding the application of functional magnetic resonance imaging (fMRI) technology in the field of acupuncture, providing new perspectives and directions for acupuncture fMRI research.</p>","PeriodicalId":12639,"journal":{"name":"Frontiers in Neuroscience","volume":"19 ","pages":"1489049"},"PeriodicalIF":3.2,"publicationDate":"2025-01-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11821919/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143414061","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Frontiers in NeurosciencePub Date : 2025-01-29eCollection Date: 2025-01-01DOI: 10.3389/fnins.2025.1557013
Shabab B Hannan, Federica De Lazzari, Aurora Gomez-Duran, Juan A Navarro, Gloria Brea-Calvo, Alvaro Sanchez-Martinez
{"title":"Editorial: Molecular and cellular pathways leading to mitochondrial dysfunction and neurodegeneration: lessons from <i>in vivo</i> models, volume II.","authors":"Shabab B Hannan, Federica De Lazzari, Aurora Gomez-Duran, Juan A Navarro, Gloria Brea-Calvo, Alvaro Sanchez-Martinez","doi":"10.3389/fnins.2025.1557013","DOIUrl":"10.3389/fnins.2025.1557013","url":null,"abstract":"","PeriodicalId":12639,"journal":{"name":"Frontiers in Neuroscience","volume":"19 ","pages":"1557013"},"PeriodicalIF":3.2,"publicationDate":"2025-01-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11814440/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143407100","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Frontiers in NeurosciencePub Date : 2025-01-29eCollection Date: 2025-01-01DOI: 10.3389/fnins.2025.1512724
Tien Cuong Phi, Shin Ishii, Masashi Kondo, Masanori Matsuzaki, Ken Nakae
{"title":"Integrated information theory reveals the potential role of the posterior parietal cortex in sustaining conditioning responses in classical conditioning tasks.","authors":"Tien Cuong Phi, Shin Ishii, Masashi Kondo, Masanori Matsuzaki, Ken Nakae","doi":"10.3389/fnins.2025.1512724","DOIUrl":"10.3389/fnins.2025.1512724","url":null,"abstract":"<p><p>Classical conditioning is a fundamental associative learning process in which repeated pairings of a conditioned stimulus (CS) with an unconditioned stimulus (US) lead to the CS eliciting a conditioned response (CR). Previous research has identified key neural regions involved in processing reward-predicting cues and mediating licking behavior. However, the mechanisms that sustain high conditioned response rates across repeated sessions remain elusive, particularly regarding how the reward expectation is represented on a session-by-session basis. While early learning phases in classical conditioning have been extensively studied, the neural mechanisms that support consistent performance over time remain unclear. In this study, we sought to understand how cortical regions, particularly the posterior parietal cortex (PPC), contribute to maintaining high CR rates across sessions. Using the core complex framework derived from Integrated Information Theory (IIT), we explored the dynamics of neural networks during sessions of high CR performance. Our findings suggest that while traditional functional connectivity (FC) methods struggled to capture the complexity of sustained behavioral engagement, the core complex framework revealed key regions, notably the PPC, that were significantly correlated with enhanced CR sessions. This work suggests the potential role of the PPC in supporting reward expectations and maintaining consistent behavioral responses. By applying the core complex framework to investigate neural substrates of sustained behavior, we provide novel insights into the interaction of cortical networks during classical conditioning, offering promising directions for future research in associative learning and behavior.</p>","PeriodicalId":12639,"journal":{"name":"Frontiers in Neuroscience","volume":"19 ","pages":"1512724"},"PeriodicalIF":3.2,"publicationDate":"2025-01-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11814451/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143407074","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Frontiers in NeurosciencePub Date : 2025-01-29eCollection Date: 2024-01-01DOI: 10.3389/fnins.2024.1488603
Dominik Langgartner, Anna-Lena J Weiss, Mattia Amoroso, John D Sterrett, Christopher A Lowry, Stefan O Reber
{"title":"Effects of repeated intragastric administrations with heat-inactivated <i>Mycobacterium aurum</i> DSM 33539 on the stress-induced aggravation of dextran sulfate sodium (DSS) colitis in C57BL/6N mice.","authors":"Dominik Langgartner, Anna-Lena J Weiss, Mattia Amoroso, John D Sterrett, Christopher A Lowry, Stefan O Reber","doi":"10.3389/fnins.2024.1488603","DOIUrl":"10.3389/fnins.2024.1488603","url":null,"abstract":"<p><p>Stress-protective effects have been reported for <i>M. vaccae</i> NCTC 11659 and <i>M. vaccae</i> ATCC 15483<sup>T</sup>. However, it remains to be investigated whether also closely related rapidly growing environmental saprophytic non-tuberculous mycobacteria (NTM) species have protective effects against the negative consequences of chronic psychosocial stress. Therefore, the aim of the current study was to assess whether repeated i.g. administrations of a heat-inactivated preparation of <i>Mycobacterium aurum</i> DSM 33539 prior to 19 days of chronic subordinate colony housing (CSC) are able to ameliorate the negative effects of this preclinically validated mouse model for chronic psychosocial stress on subsequent dextran sulfate sodium (DSS) colitis in male C57BL/6N mice. The results of the present study show that repeated i.g. administrations of <i>M. aurum</i> DSM 33539 have stabilizing effects on the composition of the gut microbiome, indicated by the findings that <i>M. aurum</i> DSM 33539 prevented CSC-induced increases in the relative abundances of the colitogenic phyla Desulfobacterota and Deferribacterota. Indeed, the relative abundance of Deferribacterota on day 19 was strongly correlated with histological damage to the colon. In line with the latter, <i>M. aurum</i> DSM 33539 was further protective against the aggravating effects of stress on subsequent DSS colitis. Collectively, our findings confirm and extend previous findings from our group and suggest that the stress-protective effects reported for <i>M. vaccae</i> NCTC 11659 and <i>M. vaccae</i> ATCC 15483<sup>T</sup> are generalizable also to other NTM species.</p>","PeriodicalId":12639,"journal":{"name":"Frontiers in Neuroscience","volume":"18 ","pages":"1488603"},"PeriodicalIF":3.2,"publicationDate":"2025-01-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11813930/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143407098","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Frontiers in NeurosciencePub Date : 2025-01-29eCollection Date: 2025-01-01DOI: 10.3389/fnins.2025.1525027
Yu Jiang, Di Su, Jingwen Xiao, Wenbo Cheng, Yuemei Hou, Yan Zhang
{"title":"Low-level auricular vagus nerve stimulation lowers blood pressure and heart rate in paroxysmal atrial fibrillation patients: a self-controlled study.","authors":"Yu Jiang, Di Su, Jingwen Xiao, Wenbo Cheng, Yuemei Hou, Yan Zhang","doi":"10.3389/fnins.2025.1525027","DOIUrl":"10.3389/fnins.2025.1525027","url":null,"abstract":"<p><strong>Objective: </strong>To investigate the effects of low-level auricular vagus nerve stimulation (LL-aVNS) on blood pressure and heart rate in patients with paroxysmal atrial fibrillation.</p><p><strong>Methods: </strong>A total of 22 patients with paroxysmal atrial fibrillation diagnosed in Fuzhou First General Hospital Affiliated with Fujian Medical University from September 2021 to December 2022 were selected and given LL-aVNS treatment based on the original unchanged drug treatment for 4 weeks. The systolic blood pressure (SBP), diastolic blood pressure (DBP), heart rate maximum (HRmax), heart rate minimum (HRmin), left ventricular ejection fraction (LVEF), left atrial diameter (LAD), Atrial Fibrillation Severity Scale (AFSS) symptom subscale, and Memorial Symptom Assessment Scale-Heart Failure (MSAS-HF) before and after the treatment were observed and compared. In addition, adverse effects of the LL-aVNS procedure and 6-month follow-up were recorded.</p><p><strong>Results: </strong>SBP, DBP, and HRmin were lower after the treatment than before the treatment (<i>p</i> < 0.05); AFSS symptom subscale scores and MSAS-HF scores after the treatment were lower before the treatment (<i>p</i> < 0.05); itching of the skin was observed in one case during the course of LL-aVNS; and two patients were hospitalized for acute exacerbation of chronic heart failure between 4 months and 6 months after the treatment.</p><p><strong>Conclusion: </strong>LL-aVNS in patients with paroxysmal atrial fibrillation can assist in controlling blood pressure and heart rate, effectively relieving symptoms, and the treatment process is safe and feasible.</p>","PeriodicalId":12639,"journal":{"name":"Frontiers in Neuroscience","volume":"19 ","pages":"1525027"},"PeriodicalIF":3.2,"publicationDate":"2025-01-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11813895/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143407076","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Frontiers in NeurosciencePub Date : 2025-01-29eCollection Date: 2024-01-01DOI: 10.3389/fnins.2024.1516868
Qingyu Wang, Duzhen Zhang, Xinyuan Cai, Tielin Zhang, Bo Xu
{"title":"Fourier or Wavelet bases as counterpart self-attention in spikformer for efficient visual classification.","authors":"Qingyu Wang, Duzhen Zhang, Xinyuan Cai, Tielin Zhang, Bo Xu","doi":"10.3389/fnins.2024.1516868","DOIUrl":"10.3389/fnins.2024.1516868","url":null,"abstract":"<p><p>Energy-efficient spikformer has been proposed by integrating the biologically plausible spiking neural network (SNN) and artificial transformer, whereby the spiking self-attention (SSA) is used to achieve both higher accuracy and lower computational cost. However, it seems that self-attention is not always necessary, especially in sparse spike-form calculation manners. In this article, we innovatively replace vanilla SSA (using dynamic bases calculating from Query and Key) with spike-form Fourier transform, wavelet transform, and their combinations (using fixed triangular or wavelets bases), based on a key hypothesis that both of them use a set of basis functions for information transformation. Hence, the Fourier-or-Wavelet-based spikformer (FWformer) is proposed and verified in visual classification tasks, including both static image and event-based video datasets. The FWformer can achieve comparable or even higher accuracies (0.4%-1.5%), higher running speed (9%-51% for training and 19%-70% for inference), reduced theoretical energy consumption (20%-25%), and reduced graphic processing unit (GPU) memory usage (4%-26%), compared to the standard spikformer. Our result indicates the continuous refinement of new transformers that are inspired either by biological discovery (spike-form), or information theory (Fourier or Wavelet transform), is promising.</p>","PeriodicalId":12639,"journal":{"name":"Frontiers in Neuroscience","volume":"18 ","pages":"1516868"},"PeriodicalIF":3.2,"publicationDate":"2025-01-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11814459/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143407099","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Role of aquaporins in brain water transport and edema.","authors":"Yuyuan Li, Yining Wang, Xingda Huang, Hao Zhang, Youfei Guan, Xiaoyan Zhang","doi":"10.3389/fnins.2025.1518967","DOIUrl":"10.3389/fnins.2025.1518967","url":null,"abstract":"<p><p>Water serves as the primary substance in all living cells and is an essential molecule involved in numerous biological processes critical for maintaining homeostasis in the central nervous system (CNS). Disruptions in water balance can occur in conditions such as cerebral edema, where fluid accumulation results in increased intracranial pressure (ICP). Aquaporins (AQPs) are transmembrane proteins that play a vital role in the rapid transport of water across cell membranes. Various subtypes of AQPs (AQP1, AQP3, AQP4, AQP5, AQP6, AQP7, AQP8, AQP9, and AQP11) have been identified in brain tissue. This review summarizes the latest advancements in our understanding of the critical role of AQPs in regulating water transport in brain edema. Abundant evidence indicates that AQP4, the most prevalent AQP in the CNS, regulates brain water transport and contributes to both cytotoxic and vasogenic edema, suggesting that AQP4 may serve as a potential therapeutic target for brain edema. Additionally, some studies have indicated that AQP1 plays a significant role in the formation of cerebrospinal fluid (CSF) and the maintenance of steady-state ICP. However, to date, these findings have not been translated into clinical practice. There is an urgent need to develop specific AQP inhibitors and activators to explore the potential benefits of modulating the functions of AQP1 and AQP4 in the context of brain edema.</p>","PeriodicalId":12639,"journal":{"name":"Frontiers in Neuroscience","volume":"19 ","pages":"1518967"},"PeriodicalIF":3.2,"publicationDate":"2025-01-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11814447/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143407079","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Frontiers in NeurosciencePub Date : 2025-01-29eCollection Date: 2025-01-01DOI: 10.3389/fnins.2025.1552527
Tao Liu, Li Ma, Yu Chen, Rongcai Jiang
{"title":"Editorial: Neurodegeneration and cognitive impairment after traumatic brain injury.","authors":"Tao Liu, Li Ma, Yu Chen, Rongcai Jiang","doi":"10.3389/fnins.2025.1552527","DOIUrl":"10.3389/fnins.2025.1552527","url":null,"abstract":"","PeriodicalId":12639,"journal":{"name":"Frontiers in Neuroscience","volume":"19 ","pages":"1552527"},"PeriodicalIF":3.2,"publicationDate":"2025-01-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11813878/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143407102","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Frontiers in NeurosciencePub Date : 2025-01-29eCollection Date: 2025-01-01DOI: 10.3389/fnins.2025.1517228
Pantelis Lioumis, Timo Roine, Ida Granö, Dogu Baran Aydogan, Elena Ukharova, Victor H Souza, Dubravko Kičić, Risto J Ilmoniemi, Nikos Makris
{"title":"Optimization of TMS target engagement: current state and future perspectives.","authors":"Pantelis Lioumis, Timo Roine, Ida Granö, Dogu Baran Aydogan, Elena Ukharova, Victor H Souza, Dubravko Kičić, Risto J Ilmoniemi, Nikos Makris","doi":"10.3389/fnins.2025.1517228","DOIUrl":"10.3389/fnins.2025.1517228","url":null,"abstract":"<p><p>Neuromodulation is based on the principle that brain stimulation produces plastic changes in cerebral circuitry. Given the intersubject structural and functional variability, neuromodulation has a personalized effect in the brain. Moreover, because of cerebral dominance and interhemispheric functional and structural differences in the same individual, the characterization of specific brain circuitries involved is currently not feasible. This notion is extremely important for neuromodulation treatments applied in neuropsychiatry. Specifically, the efficacy of the neuromodulation treatments is critically dependent on the anatomical precision of the brain target and the circuitry which has been affected by the TMS intervention. Furthermore, for a complete understanding of how the brain behaves under stimulation, the characterization of its neurophysiological response is necessary as well. This goal can be achieved with TMS-EEG guided by current multimodal neuroimaging techniques in real time, namely MRI-based anatomical segmentation and diffusion MRI-based tractographic analysis.</p>","PeriodicalId":12639,"journal":{"name":"Frontiers in Neuroscience","volume":"19 ","pages":"1517228"},"PeriodicalIF":3.2,"publicationDate":"2025-01-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11814169/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143407077","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Frontiers in NeurosciencePub Date : 2025-01-29eCollection Date: 2025-01-01DOI: 10.3389/fnins.2025.1501374
Chan Hee Kim
{"title":"Harmonization of the fastest and densest responses reflects humanlike reaction time in mice.","authors":"Chan Hee Kim","doi":"10.3389/fnins.2025.1501374","DOIUrl":"10.3389/fnins.2025.1501374","url":null,"abstract":"<p><strong>Introduction: </strong>Reaction time (RT) is important for evaluating delayed latency in behavior. Unlike humans, whose RT usually reflects a one-to-one stimulus-response relationship, the RT of animals can show two peaks representing the fastest and densest responses in the response distribution due to multiple responses per trial and can be further delayed depending on stimulus duration.</p><p><strong>Methods: </strong>Stimulus duration was controlled to investigate whether these two peak latencies align to form a single RT. Sound cues lasting 10, 5, and 2 s, each associated with a food reward of condensed milk, were tested in three groups of 24 mice using delay conditioning paradigm. The frequency and latency of responses, along with basic indices such as accuracy, were analyzed.</p><p><strong>Results: </strong>In delay conditioning experiments using sound cues of 10, 5, and 2 s, the 2 s group exhibited the strongest positive correlations between the two peaks, as well as between the number of responses and accuracy rate, suggesting a coupling of the fastest and densest responses and a one-to-one relationship between stimulus and response.</p><p><strong>Discussion: </strong>Based on these findings, I propose harmonizing the two peaks, elicited by stimuli that induce prompt and minimal responses, as a criterion for designing animal experiments to better mimic humanlike RT.</p>","PeriodicalId":12639,"journal":{"name":"Frontiers in Neuroscience","volume":"19 ","pages":"1501374"},"PeriodicalIF":3.2,"publicationDate":"2025-01-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11813871/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143407104","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}