Pathological respiratory chemoreflex activation predicts improvement of neurocognitive function in response to comtinuous positive airway pressure therapy.

IF 3.2 3区医学 Q2 NEUROSCIENCES

Frontiers in Neuroscience Pub Date : 2025-09-24 eCollection Date: 2025-01-01 DOI:10.3389/fnins.2025.1619467

Yu-Tong Hu, Yue-Nan Ni, Hugi Hilmisson, Robert Joseph Thomas

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引用次数: 0

Abstract

Introduction: There is a need for biomarkers predicting neurocognitive improvement following treatment of obstructive sleep apnea (OSA) with continuous positive airway pressure (CPAP). The role of sleep apnea endotypes as predictors are promising.

Objective: To assess the relationship between a high loop gain biomarker, elevated low frequency narrow band (e-LFC_NB), and improvements in neurocognitive function in the Apnea Positive Pressure Long-term Efficacy Study (APPLES).

Methods: The e-LFC_NB % metric was estimated on baseline polysomnography. Logistic regression analysis was performed to identify the potential association between e-LFC_NB% of total sleep time and the observed improvement in neurocognitive function following the specified treatment.

Results: A total of 362 subjects received CPAP and had e-LFC_NB % measurements. For Sustained Working Memory Test-Overall Mid-Day (SWMT-OMD), e-LFC_NB% > 2.35% correlates positively with the proportion of participants who showed an increase in test scores > 0.65 after 2 months CPAP treatment (OR: 2.617, 95% CI: 1.095-6.252, p: 0.030); e-LFC_NB% > 9.45% correlates positively with improvement in test scores > 0.8 after 6 months CPAP treatment (OR: 2.553, 95% CI: 1.017-6.409, p: 0.046). For Buschke Selective Reminding Test sum recall (BSRT-SR), e-LFC_NB% > 3.65% correlates positively with an increase in test scores > 12 after 2 months CPAP treatment (OR: 2.696, 95% CI: 1.041-6.982, p: 0.041). Results of the Pathfinder Number Test-Total Time (PFN-TOTL) were not significant.

Conclusion: e-LFC_NB% (probable high loop gain) may be a clinically useful predictor of cognitive improvement following CPAP.

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病理性呼吸化学反射激活预测持续气道正压治疗后神经认知功能的改善。

导读：在持续气道正压通气（CPAP）治疗阻塞性睡眠呼吸暂停（OSA）后，需要生物标志物来预测神经认知改善。睡眠呼吸暂停内型作为预测因子的作用是有希望的。目的：在呼吸暂停正压长期疗效研究（apple）中评估高环增益生物标志物、低频窄带升高（e-LFCNB）与神经认知功能改善之间的关系。方法：采用基线多导睡眠描记仪估计e-LFCNB %指标。采用Logistic回归分析确定总睡眠时间e-LFCNB%与特定治疗后观察到的神经认知功能改善之间的潜在关联。结果：362例患者接受了CPAP治疗，并测量了e-LFCNB %。对于持续工作记忆测试-整体中午（SWMT-OMD）， e-LFCNB% > 2.35%与CPAP治疗2 个月后测试成绩增加> 0.65的参与者比例呈正相关（OR: 2.617, 95% CI: 1.095-6.252, p: 0.030）；e-LFCNB% > 9.45%与CPAP治疗6 个月后测试分数> 0.8的改善呈正相关（OR: 2.553, 95% CI: 1.017-6.409, p: 0.046）。对于Buschke选择性提醒测试总回忆（BSRT-SR）， e-LFCNB% > 3.65%与CPAP治疗2 个月后测试分数> 12的增加呈正相关（OR: 2.696, 95% CI: 1.041-6.982, p: 0.041）。探路者数测试-总时间（pfn - total Time）结果无显著性差异。结论：e-LFCNB%（可能的高环路增益）可能是临床有用的CPAP后认知改善的预测指标。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Frontiers in Neuroscience NEUROSCIENCES-

CiteScore

6.20

自引率

4.70%

发文量

2070

审稿时长

14 weeks

期刊介绍： Neural Technology is devoted to the convergence between neurobiology and quantum-, nano- and micro-sciences. In our vision, this interdisciplinary approach should go beyond the technological development of sophisticated methods and should contribute in generating a genuine change in our discipline.