Gastroenterology and Hepatology From Bed to Bench最新文献

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Prospective insights into acute cholangitis: microbial patterns, resistance, risk factors, and outcomes. 急性胆管炎的前瞻性研究:微生物模式、耐药性、危险因素和结果。
Gastroenterology and Hepatology From Bed to Bench Pub Date : 2025-01-01 Epub Date: 2025-12-13 DOI: 10.22037/ghfbb.v18i4.3154
Elham Ahmed Hassan, Abeer Sharaf El-Din Abdel Rehim, Asmaa Omar Ahmed, Khaled A Khalaf, Nourhan Mostafa Salama, Mohamed Zakaria Abu Rahma
{"title":"Prospective insights into acute cholangitis: microbial patterns, resistance, risk factors, and outcomes.","authors":"Elham Ahmed Hassan, Abeer Sharaf El-Din Abdel Rehim, Asmaa Omar Ahmed, Khaled A Khalaf, Nourhan Mostafa Salama, Mohamed Zakaria Abu Rahma","doi":"10.22037/ghfbb.v18i4.3154","DOIUrl":"10.22037/ghfbb.v18i4.3154","url":null,"abstract":"<p><strong>Aim: </strong>This study investigated the microbiological profile, risk factors, antimicrobial resistance, and clinical outcomes in patients with acute cholangitis.</p><p><strong>Background: </strong>Acute cholangitis is a critical infection resulting from biliary obstruction, with risks of sepsis and high mortality.</p><p><strong>Methods: </strong>This prospective study included 105 patients undergoing biliary drainage for acute cholangitis via endoscopic retrograde cholangiopancreatography or percutaneous transhepatic drainage. Bile and blood cultures were collected. Antimicrobial susceptibility testing was performed. In-hospital outcomes were analysed.</p><p><strong>Results: </strong>Bacteriologically confirmed cholangitis was identified in nearly half of the patients, with Gram-negative bacteria predominating in both bile and blood cultures. <i>Klebsiella</i> <i>pneumoniae</i> and <i>Escherichia</i> <i>coli</i> were the most common Gram-negative isolates, <i>Staphylococcus</i> <i>aureus</i> was the leading Gram-positive organism, and a small number of <i>Candida</i> species (n=5) were also recovered. Malignant biliary obstruction and higher SOFA scores were associated with positive cultures. Multidrug-resistant organisms (51.8% of isolates), including ESBL-producers and carbapenem-resistant strains, were common. <i>Enterobacteriaceae</i> remained sensitive to carbapenems and tigecycline, whereas <i>Staphylococci</i> were sensitive to linezolid and vancomycin. Culture-positive patients experienced longer hospital stays (P< 0.001) and higher mortality (10%, P= 0.016) compared with negative-culture patients.</p><p><strong>Conclusion: </strong>-negative bacteria are the primary pathogens in acute cholangitis, and the high burden of multidrug resistance is linked to worse clinical outcomes, particularly in patients with malignant obstruction. Ongoing antibiotic stewardship and local resistance are crucial to optimize empiric therapy and improve patient outcomes.</p>","PeriodicalId":12636,"journal":{"name":"Gastroenterology and Hepatology From Bed to Bench","volume":"18 4","pages":"498-508"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12920707/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147348177","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The gut-lung axis in celiac disease: a narrative review of pulmonary manifestations and pathogenic mechanisms. 乳糜泻的肠-肺轴:肺部表现和致病机制的叙述性回顾。
Gastroenterology and Hepatology From Bed to Bench Pub Date : 2025-01-01 Epub Date: 2025-12-13 DOI: 10.22037/ghfbb.v18i4.3229
Ahmed A Abdelmoaty, Maha E Alsadik, Khaled A Abdel-Sater
{"title":"The gut-lung axis in celiac disease: a narrative review of pulmonary manifestations and pathogenic mechanisms.","authors":"Ahmed A Abdelmoaty, Maha E Alsadik, Khaled A Abdel-Sater","doi":"10.22037/ghfbb.v18i4.3229","DOIUrl":"10.22037/ghfbb.v18i4.3229","url":null,"abstract":"<p><strong>Aim: </strong>This narrative review synthesizes current evidence on the association between Celiac disease (CD) and pulmonary disorders, explores underlying mechanisms, and highlights clinical implications and future research directions.</p><p><strong>Background: </strong>CD is a chronic autoimmune enteropathy triggered by gluten ingestion in genetically predisposed individuals. Although it primarily affects the small intestine, emerging evidence implicates extraintestinal involvement, particularly of the respiratory system, suggesting a potential gut-lung axis.</p><p><strong>Methods: </strong>This narrative review was conducted using PubMed, Scopus, and Web of Science, covering literature published in English up to October 2025. Search terms combined 'celiac disease' OR 'coeliac disease' with ('lung disease' OR 'pulmonary' OR 'respiratory tract' OR 'asthma' OR 'bronchiectasis' OR 'COPD' OR 'interstitial lung disease' OR 'pulmonary hemosiderosis'). Inclusion criteria were peer-reviewed human studies reporting pulmonary manifestations in celiac disease. Exclusion criteria included non-English language, in vitro or animal studies, abstracts without full text, and insufficient clinical or mechanistic data. This was not a systematic review, and therefore no PRISMA flow diagram was generated.\"</p><p><strong>Results: </strong>Large-scale registry studies in Scandinavia and case-based evidence across Europe and Asia support a spectrum of pulmonary manifestations in celiac disease, ranging from asthma and chronic cough to rare but life-threatening idiopathic pulmonary hemosiderosis. Asthma and chronic cough were the most commonly observed associations, with population-based studies reporting an elevated risk. Case reports and small cohorts described co-occurrence with bronchiectasis and interstitial lung disease, while rare cases confirmed links to idiopathic pulmonary hemosiderosis (Lane-Hamilton syndrome). Proposed mechanisms include systemic immune activation, increased intestinal and pulmonary permeability, micronutrient deficiencies, IgA deficiency, and chronic inflammation. Notably, several studies reported symptom improvement or resolution following a gluten-free diet (GFD).</p><p><strong>Conclusion: </strong>Pulmonary manifestations of CD, though relatively uncommon, are clinically significant and often reversible with dietary intervention. Greater awareness, early recognition, and mechanistic research are essential to optimize patient outcomes.</p>","PeriodicalId":12636,"journal":{"name":"Gastroenterology and Hepatology From Bed to Bench","volume":"18 4","pages":"413-417"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12920676/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147348119","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A bioinformatics analysis to identify shared molecular pathways and hub genes between NAFLD and Gestational Diabetes Mellitus. NAFLD与妊娠期糖尿病共享分子通路和枢纽基因的生物信息学分析。
Gastroenterology and Hepatology From Bed to Bench Pub Date : 2025-01-01 Epub Date: 2025-12-29 DOI: 10.22037/ghfbb.v18iSpecialIssue.3209
Nasrin Amiri-Dashatan, Mehdi Koushki, Masoumeh Farahani, Somayeh Chahkandi, Mohammad Salehi, Hossein Chiti, Zohreh Amarloo, Aliasghar Keramatinia, Mohsen Norouzinia
{"title":"A bioinformatics analysis to identify shared molecular pathways and hub genes between NAFLD and Gestational Diabetes Mellitus.","authors":"Nasrin Amiri-Dashatan, Mehdi Koushki, Masoumeh Farahani, Somayeh Chahkandi, Mohammad Salehi, Hossein Chiti, Zohreh Amarloo, Aliasghar Keramatinia, Mohsen Norouzinia","doi":"10.22037/ghfbb.v18iSpecialIssue.3209","DOIUrl":"10.22037/ghfbb.v18iSpecialIssue.3209","url":null,"abstract":"<p><strong>Aim: </strong>This research aimed to identify the possible links between Non-alcoholic fatty liver disease (NAFLD) and gestational diabetes mellitus (GDM) by examining shared genes and pathways through the use of bioinformatics tools.</p><p><strong>Background: </strong>NAFLD presents several potential risk factors for the onset of GDM.</p><p><strong>Methods: </strong>We downloaded relevant microarray datasets from the Gene Expression Omnibus (GEO) database for screening common differentially expressed genes (DEGs) between NAFLD and GDM by GEO2R. Then, we used gene ontology analysis to explore the biological processes and KEGG pathways of NAFLD and GDM occurrence. The hub genes of each disease were screened by analysis of the PPI network, and the common hub genes were identified. We designed a co-expression network and miRNA hub gene regulatory network for selected hub genes by using GeneMANIA and miRNet platforms, respectively.</p><p><strong>Results: </strong>We identified 521 and 185 DEGs for NAFLD and GDM, respectively. 10 shared genes (FOS, CD22, AMZ1, ANGPT2, ATP1B2, STAB2, EGR1, MMP9, CXCL9, and LCN2) were screened among DEGs of two diseases, with analysis revealing enrichment in pathways such as IL-7 and TNF signaling pathways. Then, common hub genes (FOS, MMP9, and CXCL9) were identified via PPI network analysis, which were strongly correlated with both diseases. In addition, has-mir-34a-5p and has-mir-335-5p were detected as shared miRs that target hubs.</p><p><strong>Conclusion: </strong>We found 3 shared hub genes involved in NAFLD and GDM. Our research established a connection between the two diseases and could aid in formulating possible intervention strategies aimed at addressing both disorders by utilizing these risk factors.</p>","PeriodicalId":12636,"journal":{"name":"Gastroenterology and Hepatology From Bed to Bench","volume":"18 SI","pages":"56-67"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13081419/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147941272","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Trauma and gastrointestinal symptoms in patients with gastroesophageal reflux disease: the role of emotional processing and mentalization. 胃食管反流病患者的创伤与胃肠道症状:情绪加工和心理化的作用。
Gastroenterology and Hepatology From Bed to Bench Pub Date : 2025-01-01 Epub Date: 2025-12-13 DOI: 10.22037/ghfbb.v18i4.3122
Zahra Karimi Ahmadabadi, Amir Sam Kianimoghaddam, Amir Sadeghi, Reyhaneh Khishe, Fateme Serjouie, Abbas Masjedi Arani
{"title":"Trauma and gastrointestinal symptoms in patients with gastroesophageal reflux disease: the role of emotional processing and mentalization.","authors":"Zahra Karimi Ahmadabadi, Amir Sam Kianimoghaddam, Amir Sadeghi, Reyhaneh Khishe, Fateme Serjouie, Abbas Masjedi Arani","doi":"10.22037/ghfbb.v18i4.3122","DOIUrl":"10.22037/ghfbb.v18i4.3122","url":null,"abstract":"<p><strong>Aim: </strong>This study seeks to determine, for the first time, whether these mechanisms account for the indirect effects of trauma on gastrointestinal symptom severity within a psychosomatic framework.</p><p><strong>Background: </strong>Gastroesophageal reflux disease (GERD) is one of the most common disorders of the digestive system, and various psychological factors may contribute to its development and exacerbation. The present study will examine these factors within a unified analytical model. Specifically, the study aimed to examine a path analysis model of the relationship between trauma and gastrointestinal symptoms in patients with GERD, with a focus on the mediating roles of emotional processing and mentalization.</p><p><strong>Methods: </strong>This cross-sectional study included 207 people with gastroesophageal reflux disease referred to Tehran Behbood Clinic, aged 18 to 60 years, selected through convenience sampling. The study was carried out between September and October 2024. The subjects completed the Gastrointestinal Symptom Rating Scale (GSRS), Mentalization Questionnaire (MQ), Childhood Trauma Questionnaire, and Emotional Information Processing Questionnaire (EIPQ). Data were analyzed using path analysis in R (lavaan package) with the Maximum Likelihood Robust (MLR) estimator to account for non-normality. Model fit was evaluated using chi-square, CFI, TLI, RMSEA, and SRMR, and direct, indirect, and total effects were calculated to examine the mediating role of emotional processing and mentalization.</p><p><strong>Results: </strong>Trauma had a significant direct effect on gastrointestinal symptoms (β = 0.242, p < 0.001). Emotional processing significantly mediated this relationship (indirect effect β = 0.039, p < 0.05). Mentalization did not show a significant direct or mediating effect on gastrointestinal symptoms (β = 0.074, p = 0.255). Model fit indices indicated excellent fit (CFI = 1.000, TLI = 1.198, RMSEA = 0.000, SRMR = 0.003).</p><p><strong>Conclusion: </strong>Based on the findings, it can be concluded that trauma and emotional processing predict gastrointestinal symptoms in patients with gastroesophageal reflux disease and need to be considered in therapeutic interventions.</p>","PeriodicalId":12636,"journal":{"name":"Gastroenterology and Hepatology From Bed to Bench","volume":"18 4","pages":"509-519"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12920709/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147348113","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Evolving etiologies of liver transplantation: a trend analysis from 2020 to 2024 at the main center of Iran. 不断发展的肝移植病因学:2020年至2024年伊朗主要中心的趋势分析
Gastroenterology and Hepatology From Bed to Bench Pub Date : 2025-01-01 DOI: 10.22037/ghfbb.v18i1.3035
Mohamad Jamalinia, Kamran Bagheri Lankarani, Seyed Ali Malek-Hosseini
{"title":"Evolving etiologies of liver transplantation: a trend analysis from 2020 to 2024 at the main center of Iran.","authors":"Mohamad Jamalinia, Kamran Bagheri Lankarani, Seyed Ali Malek-Hosseini","doi":"10.22037/ghfbb.v18i1.3035","DOIUrl":"10.22037/ghfbb.v18i1.3035","url":null,"abstract":"<p><strong>Aim: </strong>This study aimed to analyze trends in the etiologies of liver transplants at Abu Ali Sina Hospital, Shiraz, Iran, from 2020 to 2024.</p><p><strong>Background: </strong>Liver transplantation (LT) is a crucial treatment for end-stage liver disease (ESLD). Over time, the etiologies leading to LT have evolved due to changes in disease prevalence, advancements in medical treatments, and public health interventions.</p><p><strong>Methods: </strong>Etiologies of LT were categorized into nine groups: acute liver failure, autoimmune disorders, alcoholic steatohepatitis, liver cancer, vascular, metabolic dysfunction-associated steatohepatitis (MASH), viral hepatitis, metabolic disorders, and others. Trend analysis was performed using Python 3.12 programming language with appropriate libraries.</p><p><strong>Results: </strong>A total of 1579 patients, 59.9% male with a mean age of 45.12 years (SD: 13.52), were analyzed. Autoimmune disorders emerged as the leading cause of LT, increasing from 32.2% in 2020 to 40.6% in 2024 (p-trend = 0.039). Viral hepatitis cases decreased significantly from 18.1% to 3.0% (p-trend = 0.033). Liver cancer became the third leading cause in 2021, replacing viral hepatitis, while MASH consistently remained the second leading cause.</p><p><strong>Conclusion: </strong>The significant shifts in LT etiologies underscore the success of public health interventions in reducing the burden of viral-related ESLD. Additionally, the findings highlight the need for ongoing research into the prevention, early diagnosis, and management of autoimmune liver diseases, MASH, and liver cancer. These findings provide critical insights for clinicians and policymakers to enhance liver disease management and allocate resources effectively.</p>","PeriodicalId":12636,"journal":{"name":"Gastroenterology and Hepatology From Bed to Bench","volume":"18 1","pages":"115-119"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12301539/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144741953","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Helicobacter pylori infection in patients with colorectal adenocarcinoma and its association with tumor grade and location: a cross-sectional study. 结直肠腺癌患者幽门螺杆菌感染及其与肿瘤分级和部位的关系:一项横断面研究
Gastroenterology and Hepatology From Bed to Bench Pub Date : 2025-01-01 DOI: 10.22037/ghfbb.v18i2.3090
Elham Pishgar, Hoda Mahdavi
{"title":"<i>Helicobacter pylori</i> infection in patients with colorectal adenocarcinoma and its association with tumor grade and location: a cross-sectional study.","authors":"Elham Pishgar, Hoda Mahdavi","doi":"10.22037/ghfbb.v18i2.3090","DOIUrl":"10.22037/ghfbb.v18i2.3090","url":null,"abstract":"<p><strong>Aim: </strong>Given the positive results of some research, this study aimed to explore the relationship between the presence of <i>Helicobacter pylori</i> (HP) in gastric histopathology and the location and grade of tumors in an institutional sample of patients diagnosed with colorectal cancer (CRC).</p><p><strong>Background: </strong>Epidemiological studies have been conducted to investigate the association between HP infection and CRC.</p><p><strong>Methods: </strong>This cross-sectional study retrieved data from the hospital database, considering inclusion criteria and medical record availability for patients who underwent both endoscopy and colonoscopy and were diagnosed with CRC. Patients were grouped based on tumor grade and location and compared regarding the presence or absence of HP pathogen in endoscopic biopsy direct smears.</p><p><strong>Results: </strong>Data from 241 patients were available, 220 of whom had adenocarcinoma. A statistically significant relationship between tumor differentiation grade and HP positivity was observed (P= 0.001). Each 1-level increase in grade was associated with 2.2 times higher odds of HP positivity. No significant relationships existed in the analysis of tumor location related to HP positivity.</p><p><strong>Conclusion: </strong>In colorectal cancer patients, the presence of the HP pathogen may be linked to a higher likelihood of high-grade colorectal cancers. This finding needs to be explored in screening cohorts.</p>","PeriodicalId":12636,"journal":{"name":"Gastroenterology and Hepatology From Bed to Bench","volume":"18 2","pages":"246-251"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12421928/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145039897","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
First, paradigmatic case of AMA-negative primary biliary cholangiitis with rods and rings autoantibodies: report of future implications. 首先,ama阴性原发性胆道胆管炎伴棒状和环状自身抗体的典型病例:未来意义的报告。
Gastroenterology and Hepatology From Bed to Bench Pub Date : 2025-01-01 Epub Date: 2025-08-26 DOI: 10.22037/ghfbb.v18i3.3135
Roberto Roberto
{"title":"First, paradigmatic case of AMA-negative primary biliary cholangiitis with rods and rings autoantibodies: report of future implications.","authors":"Roberto Roberto","doi":"10.22037/ghfbb.v18i3.3135","DOIUrl":"10.22037/ghfbb.v18i3.3135","url":null,"abstract":"","PeriodicalId":12636,"journal":{"name":"Gastroenterology and Hepatology From Bed to Bench","volume":"18 3","pages":"264-269"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12535782/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145336780","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Prevalence of primary sclerosing cholangitis (PSC) in Iranian adult patients with inflammatory bowel disease (IBD) or liver disorders: systematic review and meta-analysis. 伊朗成年炎症性肠病(IBD)或肝脏疾病患者中原发性硬化性胆管炎(PSC)的患病率:系统回顾和荟萃分析
Gastroenterology and Hepatology From Bed to Bench Pub Date : 2025-01-01 DOI: 10.22037/ghfbb.v18i1.3046
Ehsaneh Taheri, Behzad Hatami, Fatemeh Baghalha, Sara Ashtari, Zahra Nosrati, Mohammad Reza Zali
{"title":"Prevalence of primary sclerosing cholangitis (PSC) in Iranian adult patients with inflammatory bowel disease (IBD) or liver disorders: systematic review and meta-analysis.","authors":"Ehsaneh Taheri, Behzad Hatami, Fatemeh Baghalha, Sara Ashtari, Zahra Nosrati, Mohammad Reza Zali","doi":"10.22037/ghfbb.v18i1.3046","DOIUrl":"10.22037/ghfbb.v18i1.3046","url":null,"abstract":"<p><strong>Aim: </strong>To evaluate the prevalence of primary sclerosing cholangitis (PSC) among Iranian adult patients with inflammatory bowel disease (IBD) or liver disorders.</p><p><strong>Background: </strong>PSC is a rare and chronic liver disease characterized by inflammation, fibrosis, and intra- and/or extrahepatic bile duct structure.</p><p><strong>Methods: </strong>A systematic review and meta-analysis was conducted. The Web of Science, Scopus, Pubmed, Embase, Google Scholar, and local databases, including the IranDoc, IranMedex, SID, and MagIran databases, were searched for studies published before 6th February 2023 for the prevalence of PSC among Iranian adults.</p><p><strong>Results: </strong>In total, 22 articles involving 19,747 Iranian participants were included in this meta-analysis. The overall pooled prevalence of PSC was 8% (95% CI: 5%-12%). Additionally, the prevalence of PSC stratified by gender was calculated based on four studies (n = 1402). The pooled prevalence of PSC was estimated to be 20% (95% CI: 11-31%) in males and 12% (95% CI: 3-38%) in females. The pooled prevalence of PSC was 6% (95% CI: 4-9%) in patients with IBD and 14% (95% CI: 8-23%) in patients with liver transplantation (LT).</p><p><strong>Conclusion: </strong>The pooled prevalence of PSC was 8% in Iranian adults, and the prevalence was greater in males than in females.</p>","PeriodicalId":12636,"journal":{"name":"Gastroenterology and Hepatology From Bed to Bench","volume":"18 1","pages":"10-20"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12301537/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144741958","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A gluten-free diet has a different effect on the iron profile of celiac disease and non-celiac gluten-sensitive patients with idiopathic iron deficiency anaemia. 无麸质饮食对乳糜泻和非乳糜泻麸质敏感的特发性缺铁性贫血患者的铁谱有不同的影响。
Gastroenterology and Hepatology From Bed to Bench Pub Date : 2025-01-01 DOI: 10.22037/ghfbb.v18i2.3139
Mehrdad Haghazali, Mohammad Rostami-Nejad, Abbas Hajfathali, Luca Elli, Mohsen Norouzinia, Hamid Asadzadeh-Aghdaei, Amir Sadeghi, Mahshid Akhavan Rahnama, Azadeh Anbarlou, Haniye Ghasiyari, Hamid Mohaghegh-Shalmani, Mostafa Rezaei-Tavirani, Masiha Amiri, Mohammad Reza Zali
{"title":"A gluten-free diet has a different effect on the iron profile of celiac disease and non-celiac gluten-sensitive patients with idiopathic iron deficiency anaemia.","authors":"Mehrdad Haghazali, Mohammad Rostami-Nejad, Abbas Hajfathali, Luca Elli, Mohsen Norouzinia, Hamid Asadzadeh-Aghdaei, Amir Sadeghi, Mahshid Akhavan Rahnama, Azadeh Anbarlou, Haniye Ghasiyari, Hamid Mohaghegh-Shalmani, Mostafa Rezaei-Tavirani, Masiha Amiri, Mohammad Reza Zali","doi":"10.22037/ghfbb.v18i2.3139","DOIUrl":"10.22037/ghfbb.v18i2.3139","url":null,"abstract":"<p><strong>Aim: </strong>This study aimed to assess the impact of a six-week gluten-free diet (GFD) on the iron profiles of patients with non-celiac gluten sensitivity (NCGS) and CD.</p><p><strong>Background: </strong>Iron-deficiency anaemia (IDA) is a significant clinical feature of gluten-related disorders, especially Celiac disease (CD).</p><p><strong>Methods: </strong>The study included 29 CD patients (mean age 40.28 ± 15.57 years) and 29 NCGS patients (mean age 30.31 ± 7.78 years) presenting with IDA who were enrolled in the study during 2023-2024. Haemoglobin, serum iron, serum ferritin, total iron-binding capacity (TIBC), and transferrin saturation (TSAT) levels were assessed at the beginning and after six weeks of GFD. HLA typing was conducted using the Real-time PCR-based SYBR Green method.</p><p><strong>Results: </strong>Ferritin levels significantly increased in both CD and NCGS groups after the GFD, from 43.7807 to 50.5279 ng/mL and 23.0862 to 42.9910 ng/mL, respectively. Moreover, serum iron and TSAT levels significantly increased in the NCGS group, from 64.8034 to 81.3466 μg/dL and 19.29 ± 11.70 to 23.99 ± 9.05, respectively (p = 0.003).</p><p><strong>Conclusion: </strong>The most frequent symptoms in CD and NCGS patients were bloating/bone disease (62.1%) and bone disease (37.9%), respectively. GFD was effective in improving IDA in both CD and NCGS patients. Further research is necessary to assess the therapeutic effect of GFD in patients with gastrointestinal symptoms and IDA.</p>","PeriodicalId":12636,"journal":{"name":"Gastroenterology and Hepatology From Bed to Bench","volume":"18 2","pages":"211-215"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12421926/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145039824","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Gastric granular cell tumor masquerading as gastrointestinal stromal tumor: a rare concept. 胃颗粒细胞瘤伪装成胃肠道间质瘤:一个罕见的概念。
Gastroenterology and Hepatology From Bed to Bench Pub Date : 2025-01-01 Epub Date: 2025-08-26 DOI: 10.22037/ghfbb.v18i3.3180
Swagatika Samal, Girish Kumar Pati, Kalpana Panda, Debahuti Mohaptra, Sumit Saurav Mohanty, Debakanta Mishra, Krishna Sai Sharan
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