Gastroenterology and Hepatology From Bed to Bench最新文献

{"title":"Use of stool color card as screening tool for biliary atresia in resource-constraint country.","authors":"Rubaiyat Alam, Khan Lamia Nahid, Md Omar Faruk, Elena Haque Rasna, Md Rukunuzzaman","doi":"10.22037/ghfbb.v17i2.2931","DOIUrl":"10.22037/ghfbb.v17i2.2931","url":null,"abstract":"<p><strong>Aim: </strong>The study was aimed to find out the efficacy of a stool color card (SCC) in differentiating biliary atresia (BA) from non-BA in resource-limited countries.</p><p><strong>Background: </strong>stool color screening system was introduced in 2004 which lead to marked improvement in sensitivity of detecting BA.</p><p><strong>Methods: </strong>This cross-sectional observational study was conducted from January, 2019 through July, 2022 on purposively sampled infants who developed jaundice before three months of age, had direct bilirubin of > 20 % of total with pale stool and dark urine.</p><p><strong>Results: </strong>144 cases (male, 96) were included in the study and their mean age at admission was 87.3±37.2 days and mean age at onset of jaundice was 6.1±7.7 days. BA was confirmed in 106 (73.6%) cases and 38 (26.4%) children were in non-BA group. Frequency of persistent pale stool between BA and non- BA were 88 vs 8 (83.0 % Vs 21.0 %) which was highly significant (p=0.000). Mean difference of total and direct serum bilirubin, median alanine transferase and alkaline phosphatase were not statistically significant between two groups. Median of serum gamma glutamyl transpeptidase (GGT) in BA was 570 U/L and in non-BA it was 138.0 U/L which was statistically significant (p=0.000). The sensitivity, specificity, positive predictive value, negative predictive value and accuracy of SCC were 83%, 78.9%, 91.7%, 62.5% and 81.9% respectively.</p><p><strong>Conclusion: </strong>SCC has good sensitivity to diagnose BA but failed to prove better specificity to rely simply on it. SCC may be used as early screening tool for prompt referral to appropriate medical care centers for final evaluation of BA.</p>","PeriodicalId":12636,"journal":{"name":"Gastroenterology and Hepatology From Bed to Bench","volume":"17 2","pages":"146-150"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11234486/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141590137","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"All-cause mortality of hospitalized inflammatory bowel disease patients: a multicenter study from Iran.","authors":"Sulmaz Ghahramani, Babak Tamizifar, Vahid Rajabpour, Seyedeh-Zeynab Hosseinian, Samira Saeian, Hassan Shahoon, Kamran Bagheri Lankarani","doi":"10.22037/ghfbb.v17i3.2962","DOIUrl":"10.22037/ghfbb.v17i3.2962","url":null,"abstract":"<p><strong>Aim: </strong>In this multicenter study, we investigated all causes of mortality in hospitalized inflammatory bowel disease (IBD) patients.</p><p><strong>Background: </strong>The widespread use of biologics and immune suppressive treatments, along with the longer lifespan of patients with IBD, may have changed the cause of death in this population. Knowing this may lead to better preventive and therapeutic strategies for IBD patients.</p><p><strong>Methods: </strong>This cross-sectional study reviewed records of 1926 IBD patients hospitalized in referral hospitals in Isfahan and Shiraz during 2013-2021. In nine years, 84 patients, 39 from Isfahan and 45 from Shiraz, died. We retrospectively gathered data on demographic, clinical, and laboratory information, as well as the cause of death. We extracted the cause of death from the death sheets and classified it using the International Classification of Diseases (ICD-10). Using the Kaplan-Meier model, we estimated the median survival time from disease diagnosis to death.</p><p><strong>Results: </strong>Males accounted for 47 (55%) of the deceased patients. The mean age of the patients was 48.63 ± 18.7 years. The mortality rates among hospitalized UC and CD patients were 7.2% and 7.8%, respectively. The median duration of admission to death was 8 days, with 19 (22.6%) of IBD patients dying on the first day of their hospital admission. Half of the cohort of deceased IBD patients had survived for 8 years following their disease diagnosis. 32.7% of all recorded causes of death were due to certain infectious diseases. The second and third most common causes of death were diseases of the digestive system and diseases of the circulatory system, including pulmonary embolism, accounting for 30.1% and 14.2%, respectively.</p><p><strong>Conclusion: </strong>According to this study from Iran, infectious diseases are the leading cause of death among hospitalized IBD patients. Prevention and clinical management of pulmonary embolism in IBD patients require more careful consideration. We strongly encourage population-based cohort studies to enhance the findings.</p>","PeriodicalId":12636,"journal":{"name":"Gastroenterology and Hepatology From Bed to Bench","volume":"17 3","pages":"279-287"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11413379/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142284249","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Network analysis of H. pylori effect on AGS human gastric adenocarcinoma cells gene expression profile.","authors":"Fatemeh Bandarian, Farideh Razi, Zahra Razzaghi, Mohammad Rostami Nejad, Babak Arjmand, Alireza Ahmadzadeh","doi":"10.22037/ghfbb.v17i4.3023","DOIUrl":"10.22037/ghfbb.v17i4.3023","url":null,"abstract":"<p><strong>Aim: </strong>To better understand the molecular mechanism of Helicobacter pylori (H. pylori) in adenocarcinoma, the gene expression profile of AGS cells was analyzed by complementary study.</p><p><strong>Background: </strong>Gastric cancer, as one of the most lethal malignancies in the world, is important to be studied in terms of biomarkers. On the other hand, Helicobacter pylori is one of the key risk factors in this type of disease.</p><p><strong>Methods: </strong>In this cross-sectional study, we evaluated the seroprevalence of total and IgM anti-HAV antibodies of 254 institutionalized people with intellectual disabilities. Total and IgM anti-HAV antibodies of the blood samples of these people were determined by ELISA method. Protein-protein interaction (PPI) network analysis is a bioinformatic study with validation values for biomarker identification and clarification of molecular mechanisms. Cytoscape V 3.10.2 and its application identified potential central elements of the PPI network and its corresponding roles.</p><p><strong>Results: </strong>GAPDH and P53 are the most promising candidates in this study. In addition, the microRNA signatures assessment provided more information about these biomarkers and added more value.</p><p><strong>Conclusion: </strong>Consequently, a new outlook for the relationship between gastric cancer and H. pylori was explored based on the new key biomarkers.</p>","PeriodicalId":12636,"journal":{"name":"Gastroenterology and Hepatology From Bed to Bench","volume":"17 4","pages":"415-421"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12094504/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144127276","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Advances in blood DNA methylation-based assay for colorectal cancer early detection: a systematic updated review.","authors":"Milad Khabbazpour, Masoud Tat, Ashraf Karbasi, Mohammad Ali Abyazi, Ghazal Khodadoustan, Zohreh Heidary, Majid Zaki-Dizaji","doi":"10.22037/ghfbb.v17i3.2978","DOIUrl":"10.22037/ghfbb.v17i3.2978","url":null,"abstract":"<p><strong>Aim: </strong>A systematic review was conducted to summarize the methylated circulating tumor DNA (ctDNA) markers reported over the last decade for early detection of colorectal cancer (CRC) and to identify the main technical challenges that are impeding their clinical implementation.</p><p><strong>Background: </strong>CRC is a major cause of cancer deaths worldwide, but early detection is key for successful treatment. Non-invasive methods such as methylated ctDNA testing show promise for improving detection and monitoring of CRC.</p><p><strong>Methods: </strong>A comprehensive search was performed using Web of Science, PubMed, and Scopus up to December 30, 2023, limited to articles published in the last 10 years (after 2012), while including advanced adenoma/stage 0 or stage I/II samples in biomarker validation.</p><p><strong>Results: </strong>After identifying 694 articles, removing duplicates and screening titles, abstracts, and full texts, a total of 62 articles were found to meet the inclusion criteria. Among the single biomarkers, MYO1-G, SEPT9, SDC2, and JAM3 revealed the highest sensitivity for polyps and stage I/II CRC. For multi-biomarkers with suitable sensitivity, combinations of SFRP1, SFRP2, SDC2, PRIMA1, or ALX4, BMP3, NPTX2, RARB, SDC2, SEPT9, VIM or ZFHX4, ZNF334, ELOVL2, UNC5C, LOC146880, SFMBT2, GFRA1 were identified for polyps and stage I/II CRC.</p><p><strong>Conclusion: </strong>Enhancing sensitivity and specificity of molecular screening methods is crucial for improving CRC detection. Identifying a select few valuable biomarkers is key to reducing costs, despite challenges posed by low ctDNA levels in plasma, particularly in early-stage cancers.</p>","PeriodicalId":12636,"journal":{"name":"Gastroenterology and Hepatology From Bed to Bench","volume":"17 3","pages":"225-240"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11413380/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142284248","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Worldwide research on abdominal compartment syndrome: bibliometric analysis of scientific literature (1993-2022).","authors":"Muhana Fawwazy Ilyas, Aldebaran Lado, Ardhia Fefrine Indarta, Bagus Aris Madani, Kristanto Yuli Yarso, Ida Bagus Budhi","doi":"10.22037/ghfbb.v17i4.2926","DOIUrl":"10.22037/ghfbb.v17i4.2926","url":null,"abstract":"<p><p>Continuing studies related to Abdominal Compartment Syndrome (ACS) is imperative in terms of its significant effect on morbidity and mortality rates. To establish bibliometric analysis as a comprehensive review of ACS literature. The process encompasses many phases, such as delineating search terms, beginning and refining search results, creating preliminary statistics from the data, and performing data evaluation. Scopus database was selected as the primary source, and VOSviewer software was used to visualize author networks, country affiliations, journal affiliations, and keyword associations. The analysis was conducted on January 16th, 2023, and yielded a total of 855 documents spanning the period from 1993 to 2022. Studies on ACS showed an annual increase, but it has not yet reached a mature stage. United States leads the world in terms of the highest number of publications, h-index, citations, and the involvement of renowned authors and organizations. Through an analysis of less frequently used keywords, this study identified potential themes for future investigation, including histopathology, biological markers, interleukin 6, alanine aminotransferase, early diagnosis, scoring systems, the severity of illness indices, clinical practices, patient monitoring, preoperative evaluations, minimally invasive surgery, inter-method comparisons, multicenter studies, follow-up investigations, systematic reviews, and meta-analyses. While publications in ACS journals are crucial, they alone are not exhaustive, necessitating further research.</p>","PeriodicalId":12636,"journal":{"name":"Gastroenterology and Hepatology From Bed to Bench","volume":"17 4","pages":"379-388"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12094512/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144127200","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Genotyping virulence and resistance profiles in salmonella isolated from diarrheic children in Nairobi city, Kenya.","authors":"Mark Kilongosi Webale","doi":"10.22037/ghfbb.v17i4.3026","DOIUrl":"10.22037/ghfbb.v17i4.3026","url":null,"abstract":"<p><strong>Aim: </strong>To characterize <i>salmonella</i> virulent and antibiotic resistance genes in children with diarrhea in Nairobi city, Kenya.</p><p><strong>Background: </strong><i>Salmonella</i> species carry virulent genes whose expression correlate with severity of salmonellosis. Effective treatment of salmonellosis by antibiotics is threatened by expression of antibiotic resistant genes.</p><p><strong>Methods: </strong>In a cross-sectional study, a total of 374 children below five years of age presenting with diarrhea at Mbagathi County Hospital were recruited. Stool microbiology test was used to detect <i>Salmonella</i> species. Polymerase chain reaction was employed to detect virulent and antibiotic resistant genes.</p><p><strong>Results: </strong><i>Salmonella</i> species was isolated in 9 (2.4%) children. A total of 9 (100.0%), 7 (77.8%), 9 (100.0%) and 6 (66.6%) of the isolates harbored <i>invA</i>, <i>Hila</i>, <i>sopB</i>, and <i>Stn</i> virulent genes, respectively. None (0.0%) of the isolates was resistant to gentamycin but 7 (77.8%), 7 (77.8%), 9 (100.0%), 8 (88.9%), 7 (77.8%), 6 (66.7%) and 5 (55.6%) of <i>Salmonella</i> species were resistant to ampicillin, ceftriaxone, streptomycin, ciprofloxacin, chloramphenicol, erythromycin, and tetracycline, respectively. Ampicillin (<i>citm</i>), ceftriaxone (<i>bla</i> <i>CMY</i>), streptomycin (<i>aadA1</i>), gentamycin (<i>aac(3)-IV</i>), ciprofloxacin (<i>qnr</i>), chloramphenicol (<i>catA1</i>), erythromycin (<i>ereA</i>), and tetracycline (<i>tetA</i>) resistant gene was detected in 6 (85.7%), 6 (85.7%), 9 (100.0%), 8 (100.0%), 6 (85.7%), 6 (100.0%), and 5 (100.0%) of <i>Salmonella</i> isolates which were phenotypic resistant to ampicillin, ceftriaxone, streptomycin, ciprofloxacin, chloramphenicol, erythromycin and tetracycline, respectively.</p><p><strong>Conclusion: </strong><i>Salmonella</i> species expressing virulent and antibiotic resistant genes is an important cause of gastroenteritis in children in Kenya.</p>","PeriodicalId":12636,"journal":{"name":"Gastroenterology and Hepatology From Bed to Bench","volume":"17 4","pages":"430-437"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12094503/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144127274","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dynamic thiol/disulfide homeostasis and myeloperoxidase levels in Gilbert's syndrome with mild hyperbilirubinemia.","authors":"Burak Furkan Demir, Canan Topcuoglu, Turan Turhan, Emin Altıparmak, Nisbet Yılmaz, İhsan Ateş","doi":"10.22037/ghfbb.v17i3.2968","DOIUrl":"10.22037/ghfbb.v17i3.2968","url":null,"abstract":"<p><strong>Aim: </strong>This study aimed to compare dynamic thiol/disulfide homeostasis and myeloperoxidase (MPO) levels in patients with Gilbert's syndrome (GS) and healthy controls.</p><p><strong>Background: </strong>Thiol/disulfide homeostasis and MPO levels are both associated with increased progression of atherosclerosis.</p><p><strong>Methods: </strong>The study included a total of 130 voluntary participants comprising 65 patients with GS and 65 healthy controls. These patients were selected randomly and dynamic thiol/disulfide homeostasis, MPO, complete blood count results, and biochemistry and lipid parameters were evaluated. Patients with known chronic diseases, medication usage, and acute infections were excluded from the study. Serum total thiol and native thiol levels were measured using the fully automated colorimetric method, while serum MPO levels were measured using the sandwich ELISA method.</p><p><strong>Results: </strong>We found that patients with GS had significantly higher total thiol (352.3±38.6 vs. 317.9±47.9, p<0.001) and native thiol (386.6±42.6 vs. 348.0±51.1, p<0.001) and significantly lower disulfide (15.7±4.0 vs. 17.3±4.0, p=0.022) and MPO (130.7 vs. 166.3, p=0.006). In patients with bilirubin of <1 mg/dL, total thiol and native thiol levels were lower and disulfide, disulfide/native thiol (DNT) and disulfide/total thiol (DTT) ratios, and MPO levels were higher. Patients with bilirubin of <1 mg/dL also had higher total cholesterol.</p><p><strong>Conclusion: </strong>In these patients with GS, the thiol/disulfide balance shifted towards thiols and proinflammatory MPO levels were lower. When bilirubin was <1 mg/dL, disulfide, DNT and DTT ratios, and MPO were higher. Bilirubin levels affected all parameters of thiol/disulfide homeostasis and MPO levels independently of other risk factors. In light of our results, we suggest that mild hyperbilirubinemia in cases of GS has an anti-inflammatory and antioxidant effect and may be protective against atherosclerosis.</p>","PeriodicalId":12636,"journal":{"name":"Gastroenterology and Hepatology From Bed to Bench","volume":"17 3","pages":"270-278"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11413386/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142284253","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Opium use and gastrointestinal cancers: a systematic review and meta-analysis study.","authors":"Mahsa Mohammadi, Philippe Tadger, Amir Sadeghi, Niloufar Salehi, Mohsen Rajabnia, Elham Paraandavaji, Sasan Shafiei, Ahmad Pirani, Mohammad Reza Hatamnejad, Erfan Taherifard, Fatemeh Kheshti, Arman Naderilordejani, Forough Honarfar, Khaled Rahmani, Majid Soruri, Hamed Kord Varkaneh, Omid Dadras, Ali Jahanian, Sara Rasta, Mohammad Reza Zali","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Aim: </strong>The current systematic review and meta-analysis aimed to assess the association between Gastrointestinal (GI) cancers and opium use.</p><p><strong>Background: </strong>GI malignancies are a global public health issue and are associated with many risk factors including genetic and lifestyle factors.</p><p><strong>Methods: </strong>PubMed, Web of Science, Embase and Scopus and the Google Scholar search engine in addition to Persian databases including Magiran and SID were searched using relevant keywords. The associations of opium use, long duration of opium use, high daily amount opium use and high cumulative opium use and GI cancer and various subtypes of GI cancers were estimated and pooled in format of odds ratios (OR) and their corresponding 95% confidence intervals (CI) with a random effects model.</p><p><strong>Results: </strong>22 articles that were published between 1983 and 2022 entered the analyses. There were significant relationships between opium use based on crude effect sizes (OR: 2.53, 1.95-3.29) and adjusted effect sizes (OR: 2.64, 1.99-3.51), high daily opium use (or: 3.41, 1.92-6.06), long duration of opium use (OR: 3.03, 1.90-4.84) and high cumulative opium use (OR: 3.88, 2.35-6.41), all compared to never opium use, and GI cancer. The results were not sensitive to sensitivity analyses and no influential publication biases were found in these analyses.</p><p><strong>Conclusion: </strong>Our meta-analysis showed that opium use could be associated with increased risk of overall and some particular GI cancers including oropharyngeal, gastric, pancreatic and colorectal cancers. Opium use as a potentially modifiable factor, therefore, should be more emphasized.</p>","PeriodicalId":12636,"journal":{"name":"Gastroenterology and Hepatology From Bed to Bench","volume":"17 2","pages":"104-120"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11234493/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141590132","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Differentiation of gastric adenocarcinoma and pancreatic adenocarcinoma using immunohistochemistry biomarkers: a systematic review and meta-analysis study.","authors":"Behzad Garousi, Zahrasadat Rezaei, Yasaman Nazerian, Younes Yasaghi, Maryam Alaei, Dorsa Bahrami Zanjanbar, Arian Tavasol, Alireza Khoshrou, Sara Khademolhosseini, Hosna Mirfakhraee","doi":"10.22037/ghfbb.v17i4.3057","DOIUrl":"10.22037/ghfbb.v17i4.3057","url":null,"abstract":"<p><strong>Aim: </strong>This survey aimed to assess the differentiation of Gastric adenocarcinoma (GA) and pancreatic adenocarcinoma (PA) via immunohistochemistry biomarkers.</p><p><strong>Background: </strong>GA and PA are two gastrointestinal malignancies with similarities in immunohistochemical features, making the diagnosis complex in some cases.</p><p><strong>Methods: </strong>We searched international databases, including Google Scholar, Web of Science, PubMed, Embase, PROQUEST, and Cochrane Library, using appropriate keywords. The variance of each study was calculated using the binomial distribution formula, with all data analyzed by R version 16. Pooled odds ratios (OR), 95% confidence intervals (CI), and the I² test were calculated to evaluate the effectiveness of various immunohistochemistry biomarkers. Publication bias was assessed using funnel plots plus Begg's and Egger's tests.</p><p><strong>Results: </strong>Based on the finding of our study, four potent biomarkers which can distinguish GA from PA were Cadherin 17 (CDH17) with pooled OR= 3.73 (95% CI 1.58 to 8.87), P value=0.003, and I2=55.5%; Caudal-type homeobox 2 (CDX2) with pooled OR=8.99 (95% CI 4.52 to 17.90), P value= <0.001, and I2=52.2%; CK7 with pooled OR= 0.15 (95% CI 0.04 to 0.57), P value= 0.005, and I2=56.6%; CK20 with pooled OR=2.06 (95% CI 1.38 to 3.08), P value= <0.001, and I2=0%.</p><p><strong>Conclusion: </strong>Our study identified CDH17, COX-2, CK7, and CK20 as potent IHC biomarkers for differentiating PA and GA. Incorporating these biomarkers into routine diagnostics is essential for improving accuracy in challenging cases, ultimately aiding timely treatment decisions and improving patient outcomes.</p>","PeriodicalId":12636,"journal":{"name":"Gastroenterology and Hepatology From Bed to Bench","volume":"17 4","pages":"324-337"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12094505/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144127272","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exposure-based cognitive behavioral therapy with complementary awareness and emotional expression training for alleviating irritable bowel syndrome (IBS).","authors":"Elham Saeedinia, Hamid Poursharifi, Fereshte Momeni, Mohsen Vahedi, Mansour Abdi, Amir Sadeghi, Ramin Ghahremani","doi":"10.22037/ghfbb.v17i4.2930","DOIUrl":"10.22037/ghfbb.v17i4.2930","url":null,"abstract":"<p><strong>Aim: </strong>The present study presents a new combined approach for the treatment of irritable bowel syndrome (IBS), in which the effect of Cognitive Behavioral Therapy (CBT) based on exposure to awareness and emotional expression on patients' symptoms is examined.</p><p><strong>Background: </strong>IBS is one of the most common functional gastrointestinal diseases where psychological distress is an integral part of its presentation.</p><p><strong>Methods: </strong>We performed a clinical trial study on 30 patients with IBS. They were divided into two groups receiving the intervention and waiting list control. All patients were evaluated by IBS quality of life scale, IBS severity score, hospital anxiety and depression scale and visceral sensitivity index in three stages: pre-test, pre-test, and one-month follow-up. Our treatment program for the intervention group (n=15) included 10 group sessions, every week for 90 minutes, based on an exposure-based cognitive behavioral therapy protocol. Also, they underwent three 90-minute sessions of an emotional expression and awareness training program.</p><p><strong>Results: </strong>The mean age of the participants was 31.0±8.77 years old. No previous history of substance addiction, psychiatric, or neurologic diseases was seen. Twenty participants (66.7%) were single, twenty-three participants (76.7%) had a university degree, and 9 participants were unemployed. No significant difference was seen between the case and control groups regarding education, occupation, and marital status. All pairwise comparisons of pre-test, post-test, and follow-up IBS-QOL scores were significant between the two groups (p<0.001). Similarly, pre- and post-, and pre- and follow-up test differences for IBS-SSS and VSI were significantly different between the two groups.</p><p><strong>Conclusion: </strong>Exposure-based CBT combined with emotional expression and awareness training could alleviate the IBS symptoms, reduce visceral sensitivity, and improve quality of life.</p>","PeriodicalId":12636,"journal":{"name":"Gastroenterology and Hepatology From Bed to Bench","volume":"17 4","pages":"389-399"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12094508/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144127273","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}