Gastroenterology and Hepatology From Bed to Bench最新文献

{"title":"A rare differential diagnosis of inflammatory bowel disease in a young male patient; a challenging case report.","authors":"Morteza Valaei, Azita Ganji, Marieh Alizadeh","doi":"10.22037/ghfbb.v17i2.2898","DOIUrl":"10.22037/ghfbb.v17i2.2898","url":null,"abstract":"<p><strong>Background: </strong>Chronic granulomatous disease (CGD) is a rare disorder normally diagnosed in infancy.</p><p><strong>Case presentation: </strong>A 27-year-old man admitted with non-specific symptoms of CGD first underwent endoscopy, and colonoscopy procedures as primary evaluation of clinical presentation. Eighteen months after the first admission, he was referred to the emergency department for hematemesis, and critical situations, such as a severe anemic with Hgb= 2.6 mg/dl. As a result of this specific clinical presentation, urgent emergency treatment was performed, and endoscopic examination revealed ulcers and abnormalities in the duodenal bulb and jejunum. Other imaging procedures, such as sonography, and abdominal CT scans, showed splenomegaly. He underwent splenectomy, and after that, endoscopic treatment with balloon TTS dilation was scheduled, but this procedure failed. So, we decided to do a gastro-jujenostomy that alleviated the clinical symptoms. After nine months, he was referred to GOO, and endoscopic evaluation showed giant ulceration with severe stricture in the duodenum, and a polyp in the jejunostomy. Finally, Based on clinical presentation and pathologic evidence of biopsies, the patient approached CGD as the final diagnosis.</p><p><strong>Conclusion: </strong>Step-by-step, rule out of different highly suspicious diseases may result in a definite CGD diagnosis, and rapid management of these patients may increase the chance of survival.</p>","PeriodicalId":12636,"journal":{"name":"Gastroenterology and Hepatology From Bed to Bench","volume":"17 2","pages":"206-211"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11234485/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141590046","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Acute-on-chronic liver failure; prevalence, causes, predisposing factors, and outcome.","authors":"Kamran Bagheri Lankarani, Zahra Ghanbarinasab, Ramin Niknam","doi":"10.22037/ghfbb.v17i2.2888","DOIUrl":"10.22037/ghfbb.v17i2.2888","url":null,"abstract":"<p><strong>Aim: </strong>Until now, there has been disagreement regarding the prevalence, causes, predisposing factors, and outcome of ACLF (Acute-on-chronic liver failure). As a result, we have undertaken this research study.</p><p><strong>Background: </strong>ACLF is a complex syndrome with a poor prognosis.</p><p><strong>Methods: </strong>In this cross-sectional study, we evaluated the prevalence, causes, predisposing factors, and outcomes of adult cirrhotic patients with ACLF and acute decompensation (AD). ACLF was defined based on the criteria established by APASL (Asian Pacific Association for the Study of the Liver). The severity of organ failure was assessed using both EASL-CLIF (European Association for the Study of the Liver- Chronic Liver Failure) and NACSELD (North American Consortium for the Study of End-Stage Liver Disease) scores. To investigate the impact of different independent variables on mortality, survival analysis methods were used.</p><p><strong>Results: </strong>A total of 156 patients' data were analyzed in this study. The mean age of patients with ACLF (56.62±16.19 years) was significantly lower compared to the AD group (62.30±14.28 years). Nonalcoholic steatohepatitis and infection were the most common causes and predisposing factors in both AD and ACLF groups, respectively, but the difference between the two groups was not statistically significant. The most common organ failures observed were hepatic encephalopathy and respiratory failure. The probability of death at any given time for was significantly higher in ACLF patients than in the AD group (log rank test; P<0.001). The results of Cox regression analysis revealed that low blood pressure (HR 0.97; 95% CI 0.96-0.99; P<0.001) and decreased blood pH (HR 0.53; 95% CI 0.28-0.99; P=0.04) were significant risk factors associated with increased mortality.</p><p><strong>Conclusion: </strong>ACLF patients had a lower average age and higher mortality rates compared to AD. Nonalcoholic steatohepatitis was found to be the most common underlying disease in ACLF patients, while infections were identified as the predominant predisposing factor. All cases of mortality in the ACLF group were categorized as grade 3 and 4 based on the EASL-CLIF severity score. Hemodynamic instability and metabolic acidosis emerged as the most significant risk factors associated with increased mortality.</p>","PeriodicalId":12636,"journal":{"name":"Gastroenterology and Hepatology From Bed to Bench","volume":"17 2","pages":"161-170"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11234491/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141590047","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Current status of intestinal parasitic infections and associated risk factors in rural population of Guilan province, northern Iran: trichostrongyliasis is the most prevalent helminthic infection.","authors":"Keyhan Ashrafi, Maryam Shekari, Meysam Sharifdini, Mohammad Reza Mahmoudi, Zahra Atrkar Roshan, Behnaz Rahmati, Sayed Mahmoud Rezvani, Arya Omidvar, Hamed Mirjalali","doi":"10.22037/ghfbb.v17i2.2893","DOIUrl":"10.22037/ghfbb.v17i2.2893","url":null,"abstract":"<p><strong>Aim: </strong>This study aimed to determine the distribution of enteric parasitic infections and related risk factors among rural communities of Guilan province, Northern Iran, and to compare the results with the situation in the past.</p><p><strong>Background: </strong>Intestinal parasitic infections are still considered as a major public health concern, particularly in human communities with poor economy and sanitation.</p><p><strong>Methods: </strong>This cross-sectional study was performed in rural areas of Masal and Shanderman district from February to December 2020. A total of 917 stool samples were collected and examined for presence of intestinal helminthes and protozoa using direct, formalin-ether and Kato-Katz techniques.</p><p><strong>Results: </strong>A total of 156 (17%) out of 917 examined individuals were infected with intestinal parasites. The overall prevalence of protozoa, helminths and mixed infections were 11.8% (108/917), 4.5% (41/917) and 0.8% (7/917), respectively. Blastocystis was the most prevalent intestinal protozoa (9.6%) followed by Giardia lamblia (1.9%), Endolimax nana (1.1%), E. coli (0.8%) and Entamoeba hartmani (0.1%). The highest prevalence of intestinal helminths belonged to Trichostongylus spp. (3.5%) and Strongyloides stercoralis (1.3%). Statistical analysis showed significant association between giardiasis and sex (P<0.03). On the other hand, prevalence of enteric helminths was influenced by close contact with livestock, keeping herbivorous animals at home, job, education, and consumption of uncooked vegetables (P<0.05).</p><p><strong>Conclusion: </strong>The findings indicate a decreasing trend in the prevalence of intestinal parasitic infections in Guilan province in comparison to the past few decades. Hookworm infections, which was very prevalent in the area, are now rare, while trichostrongylosis showed a high prevalence in rural residents of the study area.</p>","PeriodicalId":12636,"journal":{"name":"Gastroenterology and Hepatology From Bed to Bench","volume":"17 2","pages":"187-197"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11234483/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141590048","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The link between gluten intake and the risk of cancers.","authors":"Sajjad Bakhtiari, Nastaran Asri, Sepehr Maleki, Saba Rahimi, Amirreza Jabbari, Alireza Ahmadzadeh, Somayeh Jahani-Sherafat, Masoumeh Farahani, Ehsan Nazemalhosseini Mojarad, Mohammad Rostami-Nejad","doi":"10.22037/ghfbb.v17i2.2945","DOIUrl":"10.22037/ghfbb.v17i2.2945","url":null,"abstract":"<p><p>Gluten is a complex mixture of hundreds of related proteins, with the two major groups being gliadin and glutenin. Gliadin primarily affects the viscosity of dough, while glutenin contributes to its strength. Nowadays, there is evidence suggesting an increase in gluten exposure due to advancements in cereal technology. Consumption of gluten can lead to development of gluten-related disorders (GRDs) in susceptible individuals. Some GRDs have been strongly associated with an increased risk of developing certain types of cancer. Colorectal cancer and lymphoma are among the most commonly reported malignancies associated with GRDs. Dietary factors, including gluten intake, have been recognized as significant modifiable risk factors for the development of digestive system cancers. The present study aimed to collect current information on the effect of gluten on the incidence of cancer in the general population and among GRDs patients. Protein-Protein Interaction (PPI) Network analysis of common genes between celiac disease (CD) and cancer was also conducted.</p>","PeriodicalId":12636,"journal":{"name":"Gastroenterology and Hepatology From Bed to Bench","volume":"17 2","pages":"132-139"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11234494/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141590135","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation strategy of anti-mitochondrial antibodies M2-negative: the role of multiplex rodent tissues and related clinical implications.","authors":"Chiara Tolassi, Roberto Assandri","doi":"10.22037/ghfbb.v17i1.2879","DOIUrl":"10.22037/ghfbb.v17i1.2879","url":null,"abstract":"<p><p>Indirect immunofluorescence on HEp-2 cell line (HEp-2-IIF) remains \"gold standard\" method for the detection of antinuclear antibodies (ANA). ANA is an operative definition, showing the possibility of autoantibodies (Aab) to bind nuclear, and cytoplasmic antigens. One of the major examples is represented by anti-mitochondrial antibodies (AMAs), which target proteins of the inner and outer mitochondrial membranes, located into the cytoplasm. The standard IIF on rat kidney/stomach/liver tissue sections, with the combined use of other commercial assays, may all be used in ordinary lab life to validate the AC-21 pattern on Hep-2 cells. The routine lab experience teaches that commercial kits cannot always be detected and define specific AMAs. In these cases the literature proposes the use of other homemade assays to detect AMAs as immunoprecipitation (IP) and Western blot (IP-WB). However, using IP or IP-WB is difficult to apply in a routine laboratory, because of numerous cases to process and the related troubles. Where find confirmation of the AC-21 pattern if line-immunoblot and other routine methods (ELISA, CLIA/FEIA assays) fail? We review AC-21 AMA-like sera from our patients (year 2022) and propose a revised diagnostic algorithm based on the combined use of IIF on Hep-2 cells, line immunoblot and IIF on rodent tissue as a third line method. We demonstrated that, particularly in cases where the second level test was unsuccessful, the application of IFI on rodent tissues became indispensable to verify the existence of AMAs.</p>","PeriodicalId":12636,"journal":{"name":"Gastroenterology and Hepatology From Bed to Bench","volume":"17 1","pages":"1-7"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11080696/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140911918","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Abdominal pain in a young lady with inverted Meckel's diverticulum: a case report.","authors":"Seyed Mohammad Reza Nejatollahi, Keihan Mostafavi, Fariba Ghorbani","doi":"10.22037/ghfbb.v17i1.2815","DOIUrl":"10.22037/ghfbb.v17i1.2815","url":null,"abstract":"<p><p>Meckel diverticulum is the most common congenital anomaly of the gastrointestinal tract which is located in small bowel within 2 feet of the ileocecal valve. Nevertheless, an inverted Meckel's diverticulum is an uncommon condition believed to result from aberrant peristalsis in that specific area. This article showed signs, symptoms, and possible clinical presentations using CARE guidelines in a case of inverted Meckel's diverticulum and reviews other possible features lastly, definitive treatment, results, and case follow-up were shown to refresh, and raise surgeons' awareness of this rare disorder.</p>","PeriodicalId":12636,"journal":{"name":"Gastroenterology and Hepatology From Bed to Bench","volume":"17 1","pages":"100-103"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11080686/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140913696","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"To vaccinate or not: hepatitis a seroprevalence in institutionalized patients with intellectual disability.","authors":"Pooya Hosseini-Monfared, Ghazal Arjmand, Maryam Vaezjalali","doi":"10.22037/ghfbb.v17i4.2984","DOIUrl":"10.22037/ghfbb.v17i4.2984","url":null,"abstract":"<p><strong>Aim: </strong>Our goal was to assess the need for vaccination and preventive measures in this vulnerable population.</p><p><strong>Background: </strong>HAV is the most common form of acute viral hepatitis, transmitted primarily via fecal-oral route. Therefore, poor hygiene and close contact among institutionalized people are associated with higher HAV infection prevalence. We sought to determine the seroprevalence of anti-HAV antibodies among institutionalized individuals with intellectual impairments in light of Iran's falling trend in HAV antibody prevalence.</p><p><strong>Methods: </strong>In this cross-sectional study, we evaluated the seroprevalence of total and IgM anti-HAV antibodies of 254 institutionalized people with intellectual disabilities. Total and IgM anti-HAV antibodies of the blood samples of these people were determined by ELISA method.</p><p><strong>Results: </strong>The seroprevalence of total and IgM anti-HAV antibodies among institutionalized people with intellectual disability were 15.4% and 0.4% respectively. In comparison to other institutionalized patients, individuals who were elderly and had spent more time in the institutions exhibited a higher prevalence of anti-HAV antibodies (p-values= 0.011 and <0.001, for example).</p><p><strong>Conclusion: </strong>Based on our study, intellectually disabled people have a low prevalence of anti-HAV antibodies, which increases with age and the duration of institutionalization. Therefore, vaccination is necessary to prevent serious infection in these people.</p>","PeriodicalId":12636,"journal":{"name":"Gastroenterology and Hepatology From Bed to Bench","volume":"17 4","pages":"409-414"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12094502/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144127199","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Molecular mechanism detection of stage I to stage II transition of esophageal squamous cell carcinoma: a system biology approach.","authors":"Mitra Rezaei, Fatemeh Bandarian, Farideh Razi, Zahra Razzaghi, Ayad Bahadori Monfared, Babak Arjmand, Reza M Robati, Alireza Ahmadzadeh","doi":"10.22037/ghfbb.v17i4.3013","DOIUrl":"10.22037/ghfbb.v17i4.3013","url":null,"abstract":"<p><strong>Aim: </strong>Molecular mechanism detection of stage I to stage II transition of esophageal squamous cell carcinoma via protein-protein interaction (PPI) network analysis is the main aim of this study.</p><p><strong>Background: </strong>Esophageal cancer (EC) is recognized as cancer with a very poor prognosis and malignancy. It is characterized by a high prevalence rate within the world and a very low survival rate, even with treatment.</p><p><strong>Methods: </strong>To detect esophageal squamous cell carcinoma (ESCC) related genes, gene expression profiles (GEPs) of GSE161533 from the Gene Expression Omnibus (GEO) database were considered to be analyzed. Data was evaluated via the GEO2R program to explore the significant differential genes (DEGs) associated to stages I and II of esophageal squamous cell carcinoma. Each analysis's top 250 significant DEGs were evaluated, and the non-common genes were assessed via PPI network analysis. The hub-bottleneck DEGs were determined and enriched via gene ontology.</p><p><strong>Results: </strong>Results indicate 373 significant DEGs discriminate stage I from stage II. PPI network analysis associated with gene expression assessment showed that COL1A1, SERPINE1, PDGFRB, AURKA, TGFBI, LGALS3, BRCA1, and TFRC are the critical DEGs which are related to ESCC transition state from stage I to II of disease. A total of 13 biological processes and molecular functions were related to the crucial genes.</p><p><strong>Conclusion: </strong>In conclusion, the Upregulation of COL1A1, SERPINE1, PDGFRB, AURKA, TGFB1, and LGALS3 and downregulation of BRCA1 and TFRC in stage II of ESCC relative to stage I were pointed out as the key events which are associated with promotion of stage I to stage II transition.</p>","PeriodicalId":12636,"journal":{"name":"Gastroenterology and Hepatology From Bed to Bench","volume":"17 4","pages":"422-429"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12094509/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144127275","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Design and development of a self-care application for patients with liver cirrhosis.","authors":"Zahra Asadzadeh, Elham Maserat, Leila Alizadeh, Zeinab Mohammadzadeh","doi":"10.22037/ghfbb.v17i1.2846","DOIUrl":"10.22037/ghfbb.v17i1.2846","url":null,"abstract":"<p><strong>Aim: </strong>Due to the capabilities of the mobile application in the self-care of patients, the present study was conducted to design and evaluate a mobile-based self-care application for patients with liver cirrhosis.</p><p><strong>Background: </strong>Liver cirrhosis is a progressive and chronic disease that, if left untreated, leads to liver cancer and, finally, the death of the patient.</p><p><strong>Methods: </strong>This study was conducted in six phases, including determining and confirming the validity of the minimum data set and capabilities for the application, designing a conceptual and logical model and determining the technical capabilities, designing the application, evaluating the prototype usability in a laboratory environment by technical experts, evaluation of the application usability in a real environment by 30 patients with QUIS (Questionnaire of User Interface Satisfaction) questionnaire.</p><p><strong>Results: </strong>The designed application has capabilities such as calculating the patient's MELD score (Model for End-Stage Liver Disease), medication reminder, location in emergency, and conversation with the physician. The results showed that the patients evaluated the application with a score of 7.94 (out of 9 points) at a good level.</p><p><strong>Conclusion: </strong>The self-care application can help patients with liver cirrhosis and their families access the necessary information related to the special care of the patient at any time and place; it also helps better manage the patient's life, improve the quality of life, and monitor the patient. These applications can effectively manage chronic diseases by reducing the burden of referrals and costs.</p>","PeriodicalId":12636,"journal":{"name":"Gastroenterology and Hepatology From Bed to Bench","volume":"17 1","pages":"74-86"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11080697/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140911915","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Investigation of <i>GNB1</i> derivative circular RNAs <i>hsa_circ_0009361</i> and <i>hsa_circ_0009362</i> expressions in colorectal cancer patients: potential new diagnostic factors.","authors":"Zahra Mozooni, Nafiseh Golestani, Hossein Sadeghi","doi":"10.22037/ghfbb.v17i1.2863","DOIUrl":"10.22037/ghfbb.v17i1.2863","url":null,"abstract":"<p><strong>Aim: </strong>We aim to investigate the relationship between <i>hsa_circ_0009361</i> plus <i>hsa_circ_0009362</i> expression levels and the clinicopathological features of colorectal cancer (CRC) patients.</p><p><strong>Background: </strong>Circular RNAs (circRNAs) are implicated in the progression and development of CRC. CircRNAs have been recognized as diagnostic and prognostic biomarkers, opening up a new window to comprehend the molecular basis of CRC. Given the significance of circRNAs and the G protein subunit b1 (<i>GNB1</i>) gene in malignancies, the goal of the current investigation was to determine the expression levels of <i>GNB1</i> derivative circular RNAs circGNB1 (<i>hsa_circ_0009361</i> and <i>hsa_circ_0009362</i>) in CRC and adjacent control tissues.</p><p><strong>Methods: </strong>The expression levels of the <i>GNB1</i> derivative circular RNAs (<i>hsa_circ_0009361</i> and <i>hsa_circ_0009362</i>) were evaluated using the quantitative real-time PCR (qRT-PCR) method in 45 CRC tissues and adjacent control tissues. Furthermore, we analyzed the diagnostic power of the mentioned circRNAs by plotting the receiver operating characteristic (ROC) curve. The association between the expression levels of <i>hsa_circ_0009361</i> and <i>hsa_circ_0009362</i> was evaluated using correlation analysis.</p><p><strong>Results: </strong>Our results revealed that the expression levels of <i>hsa_circ_0009361</i> and <i>hsa_circ_0009362</i> were significantly down-regulated in CRC tissues compared to the adjacent control group. Analysis of patients' clinicopathological features indicated that expressions of <i>hsa_circ_0009361</i> and <i>hsa_circ_0009362</i> were differently related to lymph vascular invasion (P<0.001). ROC curve results showed that these circRNAs are good candidate diagnostic biomarkers in CRCs. Pearson's correlation test revealed a positive correlation between <i>hsa_circ_0009361</i> and <i>hsa_circ_0009362</i> expression levels (P<0.0001).</p><p><strong>Conclusion: </strong>These results demonstrated that <i>hsa_circ_0009361</i> and <i>hsa_circ_0009362</i> expression levels may be used as possible diagnostic biomarkers for CRC.</p>","PeriodicalId":12636,"journal":{"name":"Gastroenterology and Hepatology From Bed to Bench","volume":"17 1","pages":"37-44"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11080687/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140911929","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}