Gastroenterology and Hepatology From Bed to Bench最新文献

{"title":"<i>Helicobacter pylori</i> infection in patients with colorectal adenocarcinoma and its association with tumor grade and location: a cross-sectional study.","authors":"Elham Pishgar, Hoda Mahdavi","doi":"10.22037/ghfbb.v18i2.3090","DOIUrl":"10.22037/ghfbb.v18i2.3090","url":null,"abstract":"<p><strong>Aim: </strong>Given the positive results of some research, this study aimed to explore the relationship between the presence of <i>Helicobacter pylori</i> (HP) in gastric histopathology and the location and grade of tumors in an institutional sample of patients diagnosed with colorectal cancer (CRC).</p><p><strong>Background: </strong>Epidemiological studies have been conducted to investigate the association between HP infection and CRC.</p><p><strong>Methods: </strong>This cross-sectional study retrieved data from the hospital database, considering inclusion criteria and medical record availability for patients who underwent both endoscopy and colonoscopy and were diagnosed with CRC. Patients were grouped based on tumor grade and location and compared regarding the presence or absence of HP pathogen in endoscopic biopsy direct smears.</p><p><strong>Results: </strong>Data from 241 patients were available, 220 of whom had adenocarcinoma. A statistically significant relationship between tumor differentiation grade and HP positivity was observed (P= 0.001). Each 1-level increase in grade was associated with 2.2 times higher odds of HP positivity. No significant relationships existed in the analysis of tumor location related to HP positivity.</p><p><strong>Conclusion: </strong>In colorectal cancer patients, the presence of the HP pathogen may be linked to a higher likelihood of high-grade colorectal cancers. This finding needs to be explored in screening cohorts.</p>","PeriodicalId":12636,"journal":{"name":"Gastroenterology and Hepatology From Bed to Bench","volume":"18 2","pages":"246-251"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12421928/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145039897","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of success rates in intussusception reduction in children: colonoscopy versus ultrasound-guided saline enema.","authors":"Reyhaneh Naghizadeh, Ahmad Ali Davar, Alireza Teimouri, Manijeh Khalili, Mohadeseh Zadehmir","doi":"10.22037/ghfbb.v18i2.3116","DOIUrl":"10.22037/ghfbb.v18i2.3116","url":null,"abstract":"<p><strong>Aim: </strong>This study evaluated and compared the success rates of intussusception reduction in children younger under three years of age using colonoscopy versus ultrasound-guided saline enema.</p><p><strong>Background: </strong>Intussusception involves telescoping one segment of the intestine into another.</p><p><strong>Methods: </strong>This experimental study included 41 children under three years old who were diagnosed with intussusception via ultrasound and admitted for reduction treatment. Participants were randomly assigned to either the saline enema or colonoscopy intervention. Data analysis was conducted using Chi-square tests and independent T-tests, utilizing SPSS 23.</p><p><strong>Results: </strong>Among the 41 children, 16 underwent reduction via colonoscopy, achieving a success rate of 81.25% (13 out of 16). In contrast, the saline enema method demonstrated a success rate of 84% (21 out of 25). The difference in success rates between the two methods was not statistically significant. Factors such as gender, age, the location of intussusception (ileocolic vs. colocolic), and the size of the intussusception did not significantly influence the success rates for either approach. Notably, intra-abdominal free fluid was significantly associated with reduced success rates for the saline enema method (P = 0.044). At the same time, no such association was found for the colonoscopy method (P = 0.142). Additionally, the presence of lymphadenopathy between the invaginated segments significantly impacted the success of the saline enema method (P = 0.036) but did not affect colonoscopy outcomes (P = 0.375).</p><p><strong>Conclusion: </strong>The study concluded that there was no significant difference in the success rates of intussusception reductions between the colonoscopy and saline enema methods. Lymph nodes between invaginated loops and intraperitoneal fluid significantly decrease the success rate of saline enema reductions, suggesting that colonoscopy may be preferable in such cases.</p>","PeriodicalId":12636,"journal":{"name":"Gastroenterology and Hepatology From Bed to Bench","volume":"18 2","pages":"196-204"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12421923/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145040002","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"ERCP and complications of small bowel perforation.","authors":"Hesameddin Eghlimi, Amir Sadeghi, Amirhassan Rabbani, Hamidreza Movahedi","doi":"10.22037/ghfbb.v18i1.3012","DOIUrl":"10.22037/ghfbb.v18i1.3012","url":null,"abstract":"<p><p>Endoscopic retrograde cholangiopancreatography (ERCP) has become an essential treatment modality for managing biliary and pancreatic disorders. However, perforation remains one of the most concerning complications associated with ERCP and endoscopic sphincterotomy. While the incidence of perforation following ERCP is relatively low, the associated mortality rate can reach 7.8%. Diagnosis and management of perforations depend on the injury's mechanism, location, and extent, as clinical and radiographic findings suggest. This paper provides a detailed overview of the causes, classification, diagnosis, management, and prevention strategies for ERCP-related perforations.</p>","PeriodicalId":12636,"journal":{"name":"Gastroenterology and Hepatology From Bed to Bench","volume":"18 1","pages":"1-5"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12301534/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144741952","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Oncolytic viral therapy as a novel potential solution for treatment of pancreatic cancer.","authors":"Piruz Shadbash, Seyed Masoud Hosseini, Sahel Abyar, Shahrzad Shoraka, Amir Ghaemi, Nosratollah Naderi, Seyed Reza Mohebbi","doi":"10.22037/ghfbb.v18i1.3066","DOIUrl":"10.22037/ghfbb.v18i1.3066","url":null,"abstract":"<p><p>Pancreatic cancer (PC) remains one of the most formidable malignancies, with survival rates showing minimal improvement over the years despite progress in chemotherapy, targeted treatments, and radiation therapy. The development of targeted agents and chemotherapy for cancer treatment has only moderately influenced clinical results and has not significantly altered 5-year survival rates. However, with the rapid discovery of the genetic and molecular functions underlying PC, new opportunities for targeted therapies are emerging. One promising approach is oncolytic viral therapy, which has shown potential as a targeted agent for the treatment of pancreatic cancer. Based on the available evidence, oncolytic viral therapy appears to be a viable treatment option for pancreatic cancer. In the present narrative review, we explore oncolytic viruses in detail, and their potential applications in cancer therapy as a future alternative treatment are investigated.</p>","PeriodicalId":12636,"journal":{"name":"Gastroenterology and Hepatology From Bed to Bench","volume":"18 1","pages":"53-69"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12301545/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144741957","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Variations in gut microbiota in celiac disease patients: a systematic review.","authors":"Hasna Ait Said, Lahcen Elmoumou, Bouchra Rherissi, Nadia El Kadmiri","doi":"10.22037/ghfbb.v18i1.3024","DOIUrl":"10.22037/ghfbb.v18i1.3024","url":null,"abstract":"<p><strong>Aim: </strong>This review aims to summarize the characteristics of gut microbiota in celiac patients and assess its composition compared to healthy controls.</p><p><strong>Background: </strong>The gut microbiota influences the regulation of host immunity. Accordingly, alterations in the intestinal microbiota, also known as dysbiosis, have been studied in various gastrointestinal disorders, including celiac disease.</p><p><strong>Methods: </strong>We conducted a systematic review of available studies over the last decade (2013-2023). The comprehensive search was performed using various academic databases. The selected studies focused on the analysis of gut microbiota from duodenal and/or fecal samples and included both pediatric and adult populations.</p><p><strong>Results: </strong>Twenty-two articles were included following PRISMA guidelines: nine on fecal microbiota, six on duodenal microbiota, and seven on both. The findings revealed significant differences in bacterial prevalence associated with celiac disease across 17 studies, with celiac patients showing altered microbial diversity characterized by an increase in pathogenic bacteria and a decrease in beneficial bacteria such as Bifidobacterium and Lactobacillus, compared to healthy controls. However, other studies showed no significant distinction between groups of children affected by celiac disease and control groups. Some articles also highlight the effect of a gluten-free diet on the composition of the gut microbiota.</p><p><strong>Conclusion: </strong>Current data on the composition of the gut microbiome in patients with celiac disease is characterized by considerable heterogeneity and inconsistency. This highlights the need for a thorough and holistic approach to understand better these variations and their impact on the health of people with celiac disease.</p>","PeriodicalId":12636,"journal":{"name":"Gastroenterology and Hepatology From Bed to Bench","volume":"18 2","pages":"147-163"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12421936/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145039965","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Algorithmic approach for endoscopic management of colorectal polyps: an up-to-date review.","authors":"Amir Sadeghi, Ali Yousefian Astaneh, Erfan Arabpour, Mohammad Reza Zali","doi":"10.22037/ghfbb.v18i1.3085","DOIUrl":"10.22037/ghfbb.v18i1.3085","url":null,"abstract":"<p><p>With the growing incidence of colorectal cancer worldwide, mainly due to increased early detection in screening programs, usage of endoscopic techniques for management of colorectal lesions have been gaining progressive attention. Each year, more advanced endoscopic techniques come to practice and old ones find technical enhancements. By reviewing guidelines, randomized controlled trials, meta-analyses, and original research, we aim to establish an evidence-based approach for selecting the optimal endoscopic method based on the polyp size, morphology, and classification. We critically analyze the advantages, limitations, and potential complications associated with each technique, providing a comprehensive overview for clinicians and suggest areas which may yet need further studies to be conducted. Our comprehensive review can provide a framework that will help clinicians choose an approach most suitable for their patients. This review attempts to contribute to the optimization of endoscopic management in colorectal polyps, with eventual improvement in patient outcomes.</p>","PeriodicalId":12636,"journal":{"name":"Gastroenterology and Hepatology From Bed to Bench","volume":"18 1","pages":"39-52"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12301536/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144741950","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Global and regional trends in under-five diarrheal disease burden: impact of human development index and geographic disparities, 1990-2021.","authors":"Mehdi Azizmohammad Looha, Ali Saberi Shahrbabaki, Azin Mohammadpoor, Mahmoud Zamani, Zahra Sadeghloo, Melika Jameie, Hanieh Mousavi, Seyede Roxane Pooresmaeil Niaki, Hossein Mohebbi, Naghmeh Asadimanesh, Fatemeh Norouzi, Sepideh Banar, Matin Jalalinejad, Maedeh Yousefi, Sofia Shahreki Mojahed, Forough Masheghati, Mehrnoosh Ghalandarlaki, Alireza Bahadorimonfared","doi":"10.22037/ghfbb.v18i2.3158","DOIUrl":"10.22037/ghfbb.v18i2.3158","url":null,"abstract":"<p><strong>Aim: </strong>In this study, global and regional trends between 1990 and 2021 were examined by sex, level of development, and geography, and projected to 2025.</p><p><strong>Background: </strong>Diarrheal disease continues to be a leading cause of morbidity and mortality in children under the age of five (U5).</p><p><strong>Methods: </strong>We assessed GBD 2021 data for U5 children in 204 countries, 21 regions, and 7 super-regions with joinpoint regression to analyze time trends, a hybrid ARIMA-ETS-ANN model to project prevalence and mortality until 2025, and longitudinal multilevel modeling to determine the effect of development level. Spatial clustering in 1990 and 2021 was assessed with Local Moran's I.</p><p><strong>Results: </strong>In 2021, the global prevalence and mortality rates of diarrheal disease among children under five were 885.07 and 51.72 per 100,000 population, respectively. Between 1990 and 2021, global U5 mortality decreased by 80.4%, and prevalence by 71.8%. The heaviest burden remained in Sub-Saharan Africa (SSA) and South Asia (SA), though all super-regions experienced statistically significant decreases. Joinpoint regression across the entire interval (1990-2021) revealed significant overall reductions in mortality (AAPC -5.15; 95% CI: -5.19, -5.10) and prevalence (AAPC -3.98; 95% CI: -4.03, -3.94). Hybrid forecasts predict ongoing decreases through 2025, with prevalence reaching 631.3 and mortality 36.6 per 100,000 population worldwide. Multilevel models revealed steeper annual reductions in low- and medium-Human Development Index (HDI) nations, corroborated by significant time-HDI interaction terms (β=79.76 for prevalence; β=7.50 for mortality; both p<0.001), although such countries had a persisting higher absolute burden. Spatial analysis revealed enduring hotspots in SSA and SA in both 1990 and 2021, and the formation of new clusters in several high-income countries. Coldspots occurred primarily in high-income and island nations.</p><p><strong>Conclusion: </strong>Significant global advancements have lessened the burden of diarrheal disease in U5 children; yet, ongoing disparities attributed to unsafe water, poor sanitation and hygiene, undernutrition, and low maternal education underscore the necessity for combined water, sanitation, and hygiene interventions, rotavirus immunization, and community-based health education in high-risk areas.</p>","PeriodicalId":12636,"journal":{"name":"Gastroenterology and Hepatology From Bed to Bench","volume":"18 2","pages":"177-195"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12421937/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145039938","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy and safety of sphingosine-1-phosphate receptor modulators in the management of inflammatory bowel disease: a systematic review and meta-analysis.","authors":"Darmadi Darmadi, Dina Aprillia Ariestine, Herwindo Ahmad, Yan Indra Fajar Sitepu","doi":"10.22037/ghfbb.v18i2.3134","DOIUrl":"10.22037/ghfbb.v18i2.3134","url":null,"abstract":"<p><strong>Aim: </strong>To evaluate the efficacy and safety of sphingosine-1-phosphate (S1P) receptor modulators in treating ulcerative colitis (UC) and Crohn's disease (CD).</p><p><strong>Background: </strong>Inflammatory Bowel Disease (IBD) is a chronic immune-mediated condition that remains challenging to manage. S1P receptor modulators offer a novel therapeutic approach by targeting immune cell trafficking, potentially improving disease outcomes.</p><p><strong>Methods: </strong>A systematic review and meta-analysis were conducted by searching PubMed, Scopus, and Cochrane Library major electronic databases for randomized controlled trials (RCTs) investigating S1P receptor modulators in IBD. Clinical outcomes assessed included clinical remission, clinical response, endoscopic improvement, histologic remission, and serious adverse events. Pooled odds ratios (OR) with 95% confidence intervals (CI) were calculated using a fixed-effects model.</p><p><strong>Results: </strong>Seven RCTs with a total of 2,597 patients were included. S1P receptor modulators significantly improved clinical remission (OR = 1.49, 95% CI: 1.21-1.84, p < 0.001), histologic remission (OR = 1.74, 95% CI: 1.31-2.31, p < 0.001), endoscopic improvement (OR = 1.58, 95% CI: 1.23-2.04, p < 0.001), and clinical response (OR = 1.27, 95% CI: 1.05-1.54, p = 0.01). The risk of serious adverse events did not significantly differ between treatment and placebo groups (OR = 1.28, 95% CI: 0.92-1.80, p = 0.14), suggesting a favorable safety profile.</p><p><strong>Conclusion: </strong>This meta-analysis supports S1P receptor modulators, particularly ozanimod and etrasimod, as effective and safe treatments for UC. Further studies are needed to assess long-term safety and direct comparisons with existing biologic therapies.</p>","PeriodicalId":12636,"journal":{"name":"Gastroenterology and Hepatology From Bed to Bench","volume":"18 2","pages":"120-131"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12421927/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145039984","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Microvillus inclusion disease: a short review of literature.","authors":"Arya Nair Kovilveettil","doi":"10.22037/ghfbb.v18i1.3069","DOIUrl":"10.22037/ghfbb.v18i1.3069","url":null,"abstract":"<p><p>Microvillus inclusion disease (MVD) is a rare autosomal recessive disease that was first discovered in 1978 by Davidson et al., with significant mortality and morbidity within the first year of life. It presents mainly with abdominal symptoms like diarrhoea, abdominal distension, vomiting electrolyte imbalance. Sometimes, depending on the genetic mutation involved, the phenotypic manifestation can vary. Certain genetic mutations are associated with cholestasis, dilated bowel loops, and metabolic acidosis, whereas some present with nystagmus and reduced visual acuity. Electron microscopy of the duodenal biopsy sample is used as a diagnostic tool. Absence or shortening of apical microvilli with microvillus inclusion bodies in mature enterocytes, which are pathognomonic to MVD alongside periodic acid Schiff (PAS)-positive granules or vesicles in the immature enterocytes.</p>","PeriodicalId":12636,"journal":{"name":"Gastroenterology and Hepatology From Bed to Bench","volume":"18 1","pages":"6-9"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12301544/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144741956","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Psychological determinants of irritable bowel syndrome and its impact on quality of life: a machine learning approaches.","authors":"Elham Saeedinia, Hamid Poursharifi, Fereshte Momeni, Mohsen Vahedi, Amir Sadeghi, Mansour Abdi, Ramin Ghahremani","doi":"10.22037/ghfbb.v18i1.3082","DOIUrl":"10.22037/ghfbb.v18i1.3082","url":null,"abstract":"<p><strong>Aim: </strong>This study examined the associations between psychosocial factors, Irritable bowel syndrome (IBS) diagnosis, and quality of life (QOL) in both control and IBS groups. Additionally, we explored the potential influence of psychosocial factors on the onset of IBS and developed a machine-learning model for IBS prediction.</p><p><strong>Background: </strong>IBS is a prevalent gastrointestinal disorder, with various factors predicting its severity and associated symptoms.</p><p><strong>Methods: </strong>Through convenience sampling, a cross-sectional study recruited participants diagnosed with IBS (n=134) and healthy controls (n=150) from Arak Gastroenterology Clinics. Linear regression assessed the impact of psychosocial factors on IBS symptom severity and QOL. Logistic regression analyzed the association of these factors with IBS onset. Machine learning algorithms were used to predict IBS based on psychosocial features. Instruments include IBS-SSS, IBS-QOL, Toronto Alexithymia Scale (TAS-20), Visceral Sensitivity Index (VSI), and Pain Catastrophe Scale (PCS).</p><p><strong>Results: </strong>A total of 284 participants (61.27% females) were recruited in the study, with a mean age of 36.48±10.75 years. Compared to controls, IBS patients exhibited significantly higher scores on measures of pain catastrophizing scale (PCS, 40.95 vs. 27.73), somatization (13.91 vs. 6.49), and alexithymia (60.23 vs. 54.71) as well as lower VSI (40.54 vs. 72.10). For those with IBS, only difficulty identifying feelings and somatization remained associated with worse symptoms, while VSI presented an inverse correlation. Psychological factors were inversely related to QOL. Elevated levels of alexithymia (OR 1.06; 95% CI 0.48, 1.63), somatization (OR 1.80; 95%CI 1.12, 2.48), and PCS (OR 1.70; 95% CI 1.30, 2.10) were associated with a higher chance of developing IBS, while higher VSI (OR -1.65; 95% CI -1.89, -1.42) was protective. Among machine learning models, logistic regression based on these factors (excluding alexithymia) and age achieved good performance (AUC: 0.86, 95% CI: 0.78-0.94; Accuracy: 0.83, 95% CI: 0.73-0.90) in predicting IBS onset.</p><p><strong>Conclusion: </strong>Psychological factors were linked to worse IBS symptoms and quality of life. A machine learning model for IBS prediction presented promising results.</p>","PeriodicalId":12636,"journal":{"name":"Gastroenterology and Hepatology From Bed to Bench","volume":"18 1","pages":"100-114"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12301535/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144741960","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}