Seroprevalence of hepatitis E virus among solid organ transplant recipients: insights from southern Iran.

Q3 Medicine

Gastroenterology and Hepatology From Bed to Bench Pub Date : 2025-01-01 DOI:10.22037/ghfbb.v18i2.3110

Zahra Amiri, Sahar Karami, Aboulfazl Gheshlaghi, Seyed Mohammad Ali Hashemi, Bahador Sarkari, Leila Morabbi, Jamal Sarvari

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Abstract

Aim: This study assessed the prevalence of anti-Hepatitis E Virus (HEV) IgG and IgM antibodies in Solid Organ Transplant (SOT) recipients in Fars Province, southern Iran.

Background: HEV is a common cause of viral hepatitis worldwide. Immunocompromised individuals, particularly SOT recipients, are at risk of chronic HEV infection.

Methods: In this cross-sectional study, 150 serum samples were collected from SOT recipients, including those with liver, kidney, intestinal, or simultaneous pancreas-kidney transplantation. The sera were stored at -20°C and analyzed for anti-HEV IgG and IgM, using a commercial ELISA kit. Data were analyzed, using SPSS.

Results: The mean age of participants was 46.24 ± 15.14 years; with 96 (64%) being male. Anti-HEV IgG antibodies were detected in 53 (35.3%) patients. The prevalence among liver and kidney recipient recipients was 33.3% and 39.2%, respectively (p = 0.63). Anti-HEV IgG seropositivity was significantly associated with older age (p < 0.001) and elevated blood urea nitrogen levels (p = 0.008). No significant associations were observed with other demographic or clinical variables (p > 0.05). All patients tested negative for anti-HEV IgM antibodies.

Conclusion: HEV exposure is relatively common among SOT recipients in southern Iran. The significant association with elevated blood urea nitrogen levels highlights the importance of renal function monitoring in this population.

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实体器官移植受者戊型肝炎病毒的血清患病率：来自伊朗南部的见解

目的：本研究评估了伊朗南部法尔斯省实体器官移植（SOT）受者中抗戊型肝炎病毒（HEV） IgG和IgM抗体的流行情况。背景：HEV是世界范围内病毒性肝炎的常见病因。免疫功能低下的个体，特别是SOT受体，有慢性HEV感染的危险。方法：在这项横断面研究中，收集了150份SOT受者的血清样本，包括肝、肾、肠或同时胰肾移植。将血清保存在-20°C，使用商用ELISA试剂盒检测抗hev IgG和IgM。数据分析采用SPSS统计软件。结果：参与者平均年龄46.24±15.14岁；其中96人（64%）是男性。53例（35.3%）患者检测到抗hev IgG抗体。肝受体和肾受体的患病率分别为33.3%和39.2% （p = 0.63）。抗hev IgG血清阳性与年龄（p < 0.001）和血尿素氮水平升高（p = 0.008）显著相关。与其他人口统计学或临床变量无显著相关性（p < 0.05）。所有患者抗hev IgM抗体检测均为阴性。结论：HEV暴露在伊朗南部SOT接受者中相对常见。与血尿素氮水平升高的显著关联突出了在这一人群中监测肾功能的重要性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Gastroenterology and Hepatology From Bed to Bench Medicine-Gastroenterology

CiteScore

2.30

自引率

0.00%

发文量