Gastroenterology and Hepatology From Bed to Bench最新文献

{"title":"Preventive and therapeutic effects of cepharanthine on acetaminophen-induced acute liver and kidney injury in male laboratory mice.","authors":"Neda Askaripour, Ali Akbar Oroojan, Mohammad Amin Behmanesh, Pouya Imanpour, Marjan Aliabdi, Soraya Khajerezaei","doi":"10.22037/ghfbb.v18i3.3132","DOIUrl":"10.22037/ghfbb.v18i3.3132","url":null,"abstract":"<p><strong>Aim: </strong>This study aimed to evaluate the preventive and therapeutic effects of cepharanthine on APAP (N-acetyl-para-aminophenol )-induced liver and kidney injury in an experimental model.</p><p><strong>Background: </strong>Acetaminophen (APAP) is widely used as an analgesic and antipyretic drug; however, its overdose can cause acute liver and kidney injury. Cepharanthine, a natural alkaloid with antioxidant properties, has been proposed as a potential protective agent.</p><p><strong>Methods: </strong>In this experimental study 40 Male NMRI mice were divided into five groups: Control, Sham, APAP-treated, APAP + preventive cepharanthine, and APAP + therapeutic cepharanthine groups. Liver and kidney function markers, including ALT, AST, BUN, creatinine, total antioxidant capacity (TAC), and malondialdehyde (MDA), were measured. Histopathological analysis was performed to assess tissue damage. Statistical analysis was conducted using ANOVA with a significance threshold of p < 0.05.</p><p><strong>Results: </strong>APAP administration significantly increased ALT, AST (p < 0.001), and MDA (p < 0.01) while reducing TAC levels (p < 0.01) in liver and kidney tissues. Cepharanthine, particularly in the therapeutic group, reduced ALT levels (p < 0.05) and improved liver histology but did not significantly alter AST or TAC in the prevention group. In contrast, cepharanthine failed to improve kidney function markers and worsened histological damage, leading to increased tubular casts and hemorrhagic areas.</p><p><strong>Conclusion: </strong>Cepharanthine exhibited partial hepatoprotective effects against APAP-induced liver injury but did not improve kidney damage. So, this natural alkaloid does not confer a significant protective effect against acute kidney injury.</p>","PeriodicalId":12636,"journal":{"name":"Gastroenterology and Hepatology From Bed to Bench","volume":"18 3","pages":"321-332"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12535781/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145336805","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of success rates in intussusception reduction in children: colonoscopy versus ultrasound-guided saline enema.","authors":"Reyhaneh Naghizadeh, Ahmad Ali Davar, Alireza Teimouri, Manijeh Khalili, Mohadeseh Zadehmir","doi":"10.22037/ghfbb.v18i2.3116","DOIUrl":"10.22037/ghfbb.v18i2.3116","url":null,"abstract":"<p><strong>Aim: </strong>This study evaluated and compared the success rates of intussusception reduction in children younger under three years of age using colonoscopy versus ultrasound-guided saline enema.</p><p><strong>Background: </strong>Intussusception involves telescoping one segment of the intestine into another.</p><p><strong>Methods: </strong>This experimental study included 41 children under three years old who were diagnosed with intussusception via ultrasound and admitted for reduction treatment. Participants were randomly assigned to either the saline enema or colonoscopy intervention. Data analysis was conducted using Chi-square tests and independent T-tests, utilizing SPSS 23.</p><p><strong>Results: </strong>Among the 41 children, 16 underwent reduction via colonoscopy, achieving a success rate of 81.25% (13 out of 16). In contrast, the saline enema method demonstrated a success rate of 84% (21 out of 25). The difference in success rates between the two methods was not statistically significant. Factors such as gender, age, the location of intussusception (ileocolic vs. colocolic), and the size of the intussusception did not significantly influence the success rates for either approach. Notably, intra-abdominal free fluid was significantly associated with reduced success rates for the saline enema method (P = 0.044). At the same time, no such association was found for the colonoscopy method (P = 0.142). Additionally, the presence of lymphadenopathy between the invaginated segments significantly impacted the success of the saline enema method (P = 0.036) but did not affect colonoscopy outcomes (P = 0.375).</p><p><strong>Conclusion: </strong>The study concluded that there was no significant difference in the success rates of intussusception reductions between the colonoscopy and saline enema methods. Lymph nodes between invaginated loops and intraperitoneal fluid significantly decrease the success rate of saline enema reductions, suggesting that colonoscopy may be preferable in such cases.</p>","PeriodicalId":12636,"journal":{"name":"Gastroenterology and Hepatology From Bed to Bench","volume":"18 2","pages":"196-204"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12421923/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145040002","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Qualitative analysis of the impact of palm and sesame oil on liver tissue health: can histology aid diagnosis?","authors":"Mohsen Zhaleh, Makan Moradi, Maryam Ahookhash","doi":"10.22037/ghfbb.v18i4.3167","DOIUrl":"10.22037/ghfbb.v18i4.3167","url":null,"abstract":"<p><strong>Aim: </strong>The present study, by examining liver histopathology, provides valuable insights into the changes caused by palm oil and sesame oil.</p><p><strong>Background: </strong>Plant-based foods are essential for liver health because they improve liver function and prevent disease. Palm oil can affect liver function and fat metabolism owing to its high saturated fat content, and its consumption can lead to non-alcoholic fatty liver disease (NAFLD), which may advance to non-alcoholic steatohepatitis (NASH). Sesame has potent anti-inflammatory and antioxidant properties that help to reduce oxidative stress and inflammation in the liver. Despite extensive research on the health effects of various oils, studies on liver histopathology are lacking.</p><p><strong>Methods: </strong>In a controlled laboratory environment, 18 rats were divided into three groups and treated for 90 days with palm oil (15% w/w), sesame oil (7.5% w/w), or a control diet. Liver tissue was examined by histopathology, including hematoxylin-eosin and Van Gieson staining, as well as histomorphometric changes, such as sinusoid size and liver and body weight.</p><p><strong>Results: </strong>The results obtained from tissue staining, examination of sinusoid size, and liver weight measurement showed that palm oil consumption led to liver damage, inflammation, and fibrosis, whereas sesame oil protected the liver.</p><p><strong>Conclusion: </strong>Palm oil consumption should be limited as much as possible, and healthier alternatives, such as sesame oil, should be considered.</p>","PeriodicalId":12636,"journal":{"name":"Gastroenterology and Hepatology From Bed to Bench","volume":"18 4","pages":"490-497"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12920705/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147348131","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Unraveling genetic signatures: the impact of SNPs on therapy response in inflammatory bowel disease patients.","authors":"Nesa Kazemifard, Masomeh Askari, Leila Navapour, Anahita Tajik, Mina Faraji, Arvand Akbari, Navid Mogharrab, Shaghayegh Baradaran Ghavami, Hamid Asadzadeh Aghdaei","doi":"10.22037/ghfbb.v18i4.3174","DOIUrl":"10.22037/ghfbb.v18i4.3174","url":null,"abstract":"<p><strong>Background: </strong>Inflammatory bowel disease (IBD) is a chronic condition characterized by immune dysregulation and intestinal inflammation, with anti-tumor necrosis factor α (anti-TNFα) therapies being a key treatment strategy. However, therapeutic responses vary across patients due to genetic factors, necessitating the identification of predictive biomarkers to optimize outcomes. This study employs bioinformatic approaches to investigate the deleterious effects of SNPs in IBD-associated genes, focusing on the structural implications of <i>HFE</i> gene variants and the impact of <i>TNFRSF1B</i> 3' UTR SNPs on miRNA binding site alterations.</p><p><strong>Method: </strong>The study utilized a systematic literature review to identify genes influencing drug response in IBD, followed by SNP detection. SNPs were filtered based on population frequencies using global databases (gnomAD, ExAC) and Iranome for region-specific data. Structural and functional impacts of missense variants were evaluated using in silico tools and protein domain analysis via InterPro and UniProt. Additionally, molecular dynamics simulation indicated structural changes in HFE gene variants, RNA-seq data analyzed differential gene expression, and miRNASNP-v3 predicted miRNA binding site alterations in 3' UTR regions.</p><p><strong>Result: </strong>A comprehensive bioinformatics approach identified 41 key IBD drug response genes contributing to cellular pathways, with 69 coding sequence SNPs and 27 3'-UTR SNPs selected for analysis. Coding SNPs, including ABCB1 and <i>HFE</i> variants, were predicted to significantly alter protein structure and stability. RNA-seq analysis revealed <i>TNFRSF1B</i> upregulation in IBD patients, and its 3'-UTR SNPs were shown to affect miRNA binding. Molecular dynamics simulation demonstrated structural instability in the <i>HFE</i> H63D variant, suggesting functional disruption.</p><p><strong>Conclusion: </strong>This study explores genetic variations influencing anti-TNF therapy responses in IBD patients. Polymorphisms like <i>HFE</i> rs1799945 and <i>TNFRSF1B</i> SNPs are identified as pivotal markers for personalized treatment strategies. Computational findings highlight their clinical potential, emphasizing the need for experimental validation to advance precision medicine and improve therapeutic outcomes and quality of life in IBD management.</p>","PeriodicalId":12636,"journal":{"name":"Gastroenterology and Hepatology From Bed to Bench","volume":"18 SI","pages":"97-109"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13081423/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147941145","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Introducing ICAM1 as a possible drug target in treatment of eosinophilic esophagitis.","authors":"Alireza Omidi Farzin, Nikoo Hossein-Khannazer, Babak Arjmand, Nastaran Asri, Zahra Razzaghi, Mostafa Rezaei-Tavirani, Mohammad Javad Ehsani Ardakani, Hamid Mohaghegh-Shalmani","doi":"10.22037/ghfbb.v18iSpecialIssue.3235","DOIUrl":"10.22037/ghfbb.v18iSpecialIssue.3235","url":null,"abstract":"<p><strong>Aim: </strong>Determining of more details of Eosinophilic esophagitis (EoE) molecular mechanism is the main aim of this study.</p><p><strong>Background: </strong>EoE is a chronic inflammatory disease associated with eosinophilic infiltration of the squamous epithelium and malfunction of immune system. Roles of number interleukins such as IL4, IL5, and IL13 are highlighted as the dysregulated genes innEoE.</p><p><strong>Methods: </strong>The significant differentially expressed genes (DEGs) of patient sample versus health controls are explored from Gene Expression Omnibus database and evaluated via GEO2R and directed protein-protein interaction (PPI) analyses to find the key genes that promote EoE. Gene ontology enrichment was applied to screen the critical genes.</p><p><strong>Results: </strong>IL1B, ICAM1, MAPK3, RAC2, IFNG, HGF, FGF2, IRS1, CCL2, GRAP, GNAO1, TBX21, IGF1, SPI1, BMP4, FLT4, MMP2, and PDGFRB were pointed out as the critical genes associated with EoE disease. Significant roles of IL1B and FGF2 were considered as important molecular event in EoE promotion. ICAM1 was highlighted as a possible drug target in EoE treatment.</p><p><strong>Conclusion: </strong>in conclusion, ICAM1 is an excellent actor in EoE disease which have controlled by the top actors as IL1B and FGF2. However, it has controlled by IFNG. Regulation of ICAM1 is suggested as a possible therapeutic protocol to control EoE progression.</p>","PeriodicalId":12636,"journal":{"name":"Gastroenterology and Hepatology From Bed to Bench","volume":"18 SI","pages":"12-20"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13081418/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147941206","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Gut microbiome dysbiosis and inflammatory markers in severe COVID-19: links to atherosclerosis and potential therapeutic insights.","authors":"Nayebali Ahmadi, Mohammad Javad Hossein Tehrani, Ashkan Alamdary, Rasul Moukhah, Rajab Mardani, Maryam Shahali","doi":"10.22037/ghfbb.v18i4.3129","DOIUrl":"10.22037/ghfbb.v18i4.3129","url":null,"abstract":"<p><strong>Background: </strong>COVID-19 is implicated in the exacerbation of atherosclerosis, potentially leading to its clinical manifestations. The aim of this study was to evaluate serum biomarkers, including albumin (ALB), C-reactive protein (CRP), ferritin (FERR), CD16, CD18, NLRP3, interleukin-6 (IL-6), and tumor necrosis factor-alpha (TNF-α), in patients with COVID-19. In addition, assessment of microbiome profiles may provide insights into disease severity and gastrointestinal health.</p><p><strong>Method: </strong>In this case-control study, serum samples were collected from 90 individuals: 30 patients with COVID-19 admitted to the intensive care unit, 30 hospitalized patients with COVID-19, and 30 healthy individuals. Concentrations of ALB, CRP, FERR, NLRP3, CD16, CD18, IL-6, and TNF-α were measured. Quantitative PCR (qPCR) was used to assess microbial diversity in stool samples.</p><p><strong>Result: </strong>No significant age difference was noted between the patient (55.40 ± 10.34 years) and the control groups (58.34 ± 11.71 years). Substantial increases in CRP, CD-18, CD-16, IL-6, Alb, and TNF-α (P < 0.001) were observed in severe cases compared to non-severe cases. Microbiome analysis indicated a 40% decrease in Roseburia and a 35% reduction in Faecalibacterium in ICU patients.</p><p><strong>Conclusion: </strong>Evaluating these biomarkers provides critical insights into atherosclerosis susceptibility in COVID-19 patients and reveals meaningful relationships among COVID-19, atherosclerosis, and gastrointestinal health.</p>","PeriodicalId":12636,"journal":{"name":"Gastroenterology and Hepatology From Bed to Bench","volume":"18 SI","pages":"110-120"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13083812/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147941192","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Machine learning and microbiome analysis for early detection of pancreatic cancer.","authors":"Sogol Tavanaeian, Mohammad Mehdi Feizabadi, Sarvenaz Falsafi, Hamid Asadzadeh Aghdaei","doi":"10.22037/ghfbb.v18iSpecialIssue.3245","DOIUrl":"10.22037/ghfbb.v18iSpecialIssue.3245","url":null,"abstract":"<p><strong>Aim: </strong>To develop machine learning (ML) models integrating clinical and microbial predictors for early pancreatic cancer (PC) detection.</p><p><strong>Background: </strong>Pancreatic cancer is a leading cause of cancer-related mortality, with a 5-year survival rate of ~12%. Limited biomarkers and non-specific risk factors hinder early diagnosis. Emerging evidence links oral and gut microbiota, such as Fusobacterium nucleatum and Roseburia species, to PC risk, offering potential for non-invasive biomarkers.</p><p><strong>Methods: </strong>We analyzed a retrospective cohort of 40 participants (20 PC cases, 20 controls). Clinical (e.g., age, WBC) and microbial (e.g., Fusobacterium nucleatum, Roseburia-to-Fusobacterium ratio [RI/FN]) predictors were evaluated using five ML classifiers (logistic regression, SVM, random forest, naïve Bayes, neural network) under Leave-Group-Out Cross-Validation (LGOCV; 80/20 split, 200 repetitions). Elastic-net regularization and stability selection identified key predictors. Performance metrics included AUC, sensitivity, specificity, PPV, NPV, and accuracy. Nomograms were developed for clinical utility.</p><p><strong>Results: </strong>Age (AUC 97.4%) and microbial markers (e.g., RI/FN ratio, AUC 100%) showed excellent discrimination. Multivariable models using age and RI/FN achieved excellent performance (AUC 98-100%). Nomograms provided interpretable risk estimates.</p><p><strong>Conclusions: </strong>Integrating clinical and microbial predictors with ML offers a promising approach for non-invasive PC detection. The RI/FN ratio and age are robust biomarkers that warrant further validation in larger cohorts. However, the small sample size limits generalizability and warrants validation in larger cohorts.</p>","PeriodicalId":12636,"journal":{"name":"Gastroenterology and Hepatology From Bed to Bench","volume":"18 SI","pages":"76-84"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13081413/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147941138","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Variations in gut microbiota in celiac disease patients: a systematic review.","authors":"Hasna Ait Said, Lahcen Elmoumou, Bouchra Rherissi, Nadia El Kadmiri","doi":"10.22037/ghfbb.v18i1.3024","DOIUrl":"10.22037/ghfbb.v18i1.3024","url":null,"abstract":"<p><strong>Aim: </strong>This review aims to summarize the characteristics of gut microbiota in celiac patients and assess its composition compared to healthy controls.</p><p><strong>Background: </strong>The gut microbiota influences the regulation of host immunity. Accordingly, alterations in the intestinal microbiota, also known as dysbiosis, have been studied in various gastrointestinal disorders, including celiac disease.</p><p><strong>Methods: </strong>We conducted a systematic review of available studies over the last decade (2013-2023). The comprehensive search was performed using various academic databases. The selected studies focused on the analysis of gut microbiota from duodenal and/or fecal samples and included both pediatric and adult populations.</p><p><strong>Results: </strong>Twenty-two articles were included following PRISMA guidelines: nine on fecal microbiota, six on duodenal microbiota, and seven on both. The findings revealed significant differences in bacterial prevalence associated with celiac disease across 17 studies, with celiac patients showing altered microbial diversity characterized by an increase in pathogenic bacteria and a decrease in beneficial bacteria such as Bifidobacterium and Lactobacillus, compared to healthy controls. However, other studies showed no significant distinction between groups of children affected by celiac disease and control groups. Some articles also highlight the effect of a gluten-free diet on the composition of the gut microbiota.</p><p><strong>Conclusion: </strong>Current data on the composition of the gut microbiome in patients with celiac disease is characterized by considerable heterogeneity and inconsistency. This highlights the need for a thorough and holistic approach to understand better these variations and their impact on the health of people with celiac disease.</p>","PeriodicalId":12636,"journal":{"name":"Gastroenterology and Hepatology From Bed to Bench","volume":"18 2","pages":"147-163"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12421936/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145039965","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"ERCP and complications of small bowel perforation.","authors":"Hesameddin Eghlimi, Amir Sadeghi, Amirhassan Rabbani, Hamidreza Movahedi","doi":"10.22037/ghfbb.v18i1.3012","DOIUrl":"10.22037/ghfbb.v18i1.3012","url":null,"abstract":"<p><p>Endoscopic retrograde cholangiopancreatography (ERCP) has become an essential treatment modality for managing biliary and pancreatic disorders. However, perforation remains one of the most concerning complications associated with ERCP and endoscopic sphincterotomy. While the incidence of perforation following ERCP is relatively low, the associated mortality rate can reach 7.8%. Diagnosis and management of perforations depend on the injury's mechanism, location, and extent, as clinical and radiographic findings suggest. This paper provides a detailed overview of the causes, classification, diagnosis, management, and prevention strategies for ERCP-related perforations.</p>","PeriodicalId":12636,"journal":{"name":"Gastroenterology and Hepatology From Bed to Bench","volume":"18 1","pages":"1-5"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12301534/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144741952","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Oncolytic viral therapy as a novel potential solution for treatment of pancreatic cancer.","authors":"Piruz Shadbash, Seyed Masoud Hosseini, Sahel Abyar, Shahrzad Shoraka, Amir Ghaemi, Nosratollah Naderi, Seyed Reza Mohebbi","doi":"10.22037/ghfbb.v18i1.3066","DOIUrl":"10.22037/ghfbb.v18i1.3066","url":null,"abstract":"<p><p>Pancreatic cancer (PC) remains one of the most formidable malignancies, with survival rates showing minimal improvement over the years despite progress in chemotherapy, targeted treatments, and radiation therapy. The development of targeted agents and chemotherapy for cancer treatment has only moderately influenced clinical results and has not significantly altered 5-year survival rates. However, with the rapid discovery of the genetic and molecular functions underlying PC, new opportunities for targeted therapies are emerging. One promising approach is oncolytic viral therapy, which has shown potential as a targeted agent for the treatment of pancreatic cancer. Based on the available evidence, oncolytic viral therapy appears to be a viable treatment option for pancreatic cancer. In the present narrative review, we explore oncolytic viruses in detail, and their potential applications in cancer therapy as a future alternative treatment are investigated.</p>","PeriodicalId":12636,"journal":{"name":"Gastroenterology and Hepatology From Bed to Bench","volume":"18 1","pages":"53-69"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12301545/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144741957","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}