Georgian medical news最新文献

{"title":"ROLE OF ANTIOXIDANT FOLIUM EXPOSURE ON OXIDATIVE SRESS IN A VALPROIC ACID-INDUCED ANIMAL MODEL OF AUTISM.","authors":"B Oren, M Devdariani, G Beselia, N Sikharulidze, M Dashniani, M Burjanadze, I Kvachakidze, M Nebieridze, L Davlianidze, L Gumberidze, N Mitagvaria","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Introduction: </strong>Autism spectrum disorder (ASD) is associated with increased levels of oxidative stress and decreased antioxidant capacity. The present study aimed to investigate the effects of different types of herbal antioxidant supplement Folium (F) - F. Relax, F. P53, F. pX, and F. Immuno (BAO Health Resources Corporation, USA) on reducing the severity of oxidative stress in a rat model of ASD induced by prenatal administration of valproic acid (VPA).</p><p><strong>Methods: </strong>The study was conducted on male outbred white rats. Rats in the VPA treated groups (group - VPA), at 2 months of age, received intraperitoneally (17 mg/kg, for 21 days) different types of Folium. At the end of treatment, measurements were taken in both the control and experimental behaviorally characterized groups, including systemic blood pressure, heart rate, as well as oxidative (d-ROM) and antioxidant (PAT) statuses. Statistical analysis was performed using SigmaStat statistical software. Data for all parameters were analyzed statistically by one- or two-way ANOVA followed by post hoc comparisons. Student's t-test was used to compare the mean values of two independent groups.</p><p><strong>Results: </strong>The results of behavioral studies showed that prenatal VPA treatment reduced social exploration, impaired social novelty preference, decreased anxiety, and increased locomotor activity. High blood pressure [systolic (SBP) and diastolic (DBP)] was observed in rats of the VPA group, along with an increased heart rate. VPA rats also showed elevated levels of free radicals (d-ROMs) and a higher oxidative stress index (OSI), indicating the presence of oxidative stress. Notably, treatment with different types of Folium revealed that: (i) administration of all these supplements restored blood pressure (systolic SBP and diastolic DBP) to the normal range; regarding heart rate, only F. Immuno did not produce a decrease; (ii) d-ROMs levels and the OSI in the VPA group were not significantly different from those in the VP+F. pX group.</p><p><strong>Conclusion: </strong>Taken together, we provide evidence that prenatal administration of VPA to rats can induce ASD-like behavioral patterns accompanied by increased oxidative stress, as reflected by elevated levels of free radicals (d-ROMs) and a higher oxidative stress index (OSI). Based on the data obtained, it can be assumed that three of the four antioxidant supplements tested - F. Relax, F. P53, and F. Immuno, which showed positive effects on oxidative stress markers, may be suitable for use in individuals with ASD to alleviate oxidative stress and regulate blood pressure. However, to draw definitive conclusions, further research in collaboration with scientific research institutions and medical schools is required.</p>","PeriodicalId":12610,"journal":{"name":"Georgian medical news","volume":" 364-365","pages":"6-15"},"PeriodicalIF":0.0,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145274378","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"CURRENT STATUS AND PROSPECTS FOR THE DEVELOPMENT OF PEDIATRIC DOSAGE FORMS BY THE EXAMPLE OF COMBINED MELOXICAM AND VITAMIN B12 TABLETS.","authors":"S Imanalieva, B Sagindykova, R Anarbayeva, M Omirali, G Ospanova, M Ashirov","doi":"","DOIUrl":"","url":null,"abstract":"&lt;p&gt;&lt;strong&gt;Relevance: &lt;/strong&gt;In the Republic of Kazakhstan, the pharmaceutical industry is undergoing rapid development. However, there is a significant deficit of specialized dosage forms for children. The majority of pharmaceuticals employed in paediatric practice have not been subjected to clinical trials in children, resulting in irrational prescribing and an elevated risk of adverse effects. The development of paediatric dosage forms for the treatment of socially significant diseases, such as juvenile rheumatoid arthritis (JRA), is of particular urgency. This article discusses the prospect of developing combined meloxicam and vitamin B12 tablets for children, which may improve the efficacy and safety of therapy.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Materials and methods: &lt;/strong&gt;The study was carried out on the basis of South Kazakhstan Medical Academy and research testing center of JSC \"Khimpharm\". Physicochemical and technological properties of meloxicam and cyanocobalamin were studied and five model samples of core tablets were developed. Direct pressing methods, as well as dissolution and active substance release tests were used to assess the quality of tablets. The production technology included the stages of mixing, pressing and film coating.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Results: &lt;/strong&gt;According to the Register of medicines of the Republic of Kazakhstan and the Kazakhstan National Formulary, only 0.3% of the total number of medicines are intended for children. 1.7% of medicines for children are included in the list of medicines for free and (or) preferential outpatient supply to citizens of Kazakhstan. 61 preparations of meloxicam are registered on the pharmaceutical market of Kazakhstan, but there are no preparations for children among them. Combination therapy has advantages over monotherapy, the simultaneous use of several active pharmaceutical ingredients reduces the duration of treatment and reduces the need for additional drugs. The results of determining the physicochemical and technological properties of meloxicam, cyanocobalamin and excipients showed that they meet the requirements of regulatory documents. Taking this into account, the method of direct pressing was chosen as a rational way of tableting meloxicam with cyanocobalamin. The data on quality indicators (by mass, height, diameter, hardness) and dissolution kinetics study showed that the composition no.4 of model samples of meloxicam core tablets is optimal. The technology of production of combined meloxicam tablets for children with an average weight of 62.0 mg ±10% (from 55.8 mg to 68.2 mg) coated was developed, and the pilot technology was tested on 2448.00 g of tablet mass.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Conclusion: &lt;/strong&gt;The development of combined meloxicam and vitamin B12 tablets for children represents a promising direction in the field of pharmaceutics. This dosage form has the potential to enhance the effectiveness of therapy for juvenile rheumatoid arthritis and other inflammatory diseases in children,","PeriodicalId":12610,"journal":{"name":"Georgian medical news","volume":" 364-365","pages":"154-167"},"PeriodicalIF":0.0,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145274394","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"ENVIRONMENTALLY SAFE CSPBBR₃/MXENE/MWCNTS HYBRID NANOCOMPOSITES: OPTOELECTRONIC AND STRUCTURAL CHARACTERISTICS FOR POSSIBLE BIOMEDICAL AND HEALTH APPLICATIONS.","authors":"B Al-Jabery, M Al-Bahrani","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Background: </strong>Environmentally safe CsPbBr3/MXene/MWCNTs hybrid nanocomposites are of considerable interest, owing to the integrated functional properties of their components. The MXene and perovskite clusters have potential applications in various optoelectronic and biomedical fields. The hybridization of MXenes and CsPbBr3 perovskite with charge-transport/hole-diffusion-supporting MWCNTs further enhances their charge-carrier transport characteristics. Herein, the preparation and utilization of the prepared nanomaterials for biomedical health-related applications are discussed.</p><p><strong>Methods: </strong>A CsPbBr₃/MXene/MWCNTs hybrid nanocomposite was synthesized using a controlled solution-based process, followed by structural and optical characterization via transmission electron microscopy (TEM), X-ray diffraction (XRD), and UV-Vis spectroscopy. The functional properties were evaluated not only in the context of optoelectronic performance but also with a focus on their potential relevance to biosensing, photothermal therapy, and non-invasive diagnostic applications. Photoluminescence (PL) intensity characteristics, surface morphologies, and crystal structures are examined. The prepared hybrids exhibit stronger PL intensities than individual CsPbBr3 NCs. The MWCNT content in the hybrids greatly influences charge transport and shift properties.</p><p><strong>Results: </strong>The composite exhibited high crystallinity, stable interfacial bonding, and a broadened light absorption spectrum spanning 400-1100 nm. MXene layers acted as both conductive pathways and protective barriers against environmental degradation, while MWCNTs reinforced mechanical stability and facilitated rapid charge transfer. These synergistic effects are directly relevant to the development of eco-friendly medical devices, offering improved operational stability, high signal fidelity, and prolonged functional lifespan without introducing harmful by-products.</p><p><strong>Conclusion: </strong>The CsPbBr₃/MXene/MWCNTs hybrid nanocomposite represents a promising material platform for next-generation medical technologies. Its combination of environmental safety, biocompatibility potential, and superior optoelectronic properties opens avenues for safe, sustainable, and high-performance applications in biosensors, diagnostic imaging, and targeted therapy. Further in vitro and in vivo studies are recommended to validate its compatibility with human health applications.</p>","PeriodicalId":12610,"journal":{"name":"Georgian medical news","volume":" 364-365","pages":"406-414"},"PeriodicalIF":0.0,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145274140","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"DERMATOLOGIC SURGERY ROUNDS: RECONSTRUCTIVE SURGERY EMPLOYING THE SHARK ISLAND FLAP FOR BASAL CELL CARCINOMA AFFECTING THE NASAL ALA.","authors":"G Tchernev, KG Jr Tchernev, D S Krastev, N S Krastev, S Kordeva","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Reconstructive techniques in dermatologic surgery represent some of the most complex and high-risk interventions, particularly when involving anatomically and cosmetically sensitive areas. These procedures can be considered an intermediate link, combining the expertise of both plastic-reconstructive and dermatosurgical fields. The shark flap in the nasal region offers an excellent option for the reconstruction of small to medium-sized defects involving the nasal area and the nares. Following established surgical algorithms and methodical operative steps ensures optimal functional and aesthetic outcomes. We present a case of a primary defect following in the right nasal ala, following basal cell carcinoma excision, successfully reconstructed both functionally and aesthetically using a shark island pedicle flap. The postoperative results at the three-month follow-up were excellent. With this report and short update on the topic, we highlight that a carefully executed classical procedure can, in many cases, provide superior functional and aesthetic outcomes compared to modified or novel techniques.</p>","PeriodicalId":12610,"journal":{"name":"Georgian medical news","volume":" 364-365","pages":"150-153"},"PeriodicalIF":0.0,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145274194","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"TRAUMATIC ANTERIOR SHOULDER INSTABILITY: A NARRATIVE REVIEW OF CURRENT LITERATURE.","authors":"R Nassar, N Khayyat, M Halasa, F Hussain","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Background: </strong>Traumatic anterior shoulder instability (TUBS) is defined as one-directional shoulder instability that is often associated with Bankart lesions and glenoid bone loss. If not managed properly it can lead to recurrent shoulder dislocation. TUBS usually occurs as a result of traumatic dislocation. Early diagnosis and intervention are essential to achieve favorable outcomes and prevent long term complications.</p><p><strong>Aim: </strong>This narrative review offers a comprehensive overview of traumatic anterior shoulder instability, with an aim to cover all aspects including patient presentation, tools that can aid in diagnosis and both conservative and operative management options. This is done with special emphasis on patient-centered care.</p><p><strong>Materials and methods: </strong>This review is based on peer-reviewed articles and summarizes the diagnostic principles, both conservative and operative management criteria, and recent operative techniques including arthroscopic Bankart repair, and the Latarjet procedure.</p><p><strong>Results: </strong>The diagnosis of TUBS is multifactorial, depending on factors such as patient history, clinical tests and imagining such as MRI to evaluate the soft tissue and assess bone integrity. Conservative treatment was found to be a suitable option for elderly patients, but young active individuals benefited more from surgery. The choice of which operative technique to use depends on the extent of bone loss and patient-specific factors.</p><p><strong>Conclusion: </strong>Effective treatment of traumatic anterior shoulder instability requires a personalized approach, with consideration for anatomical variation, recurrence rates and the patient's activities of daily living. While Conservative management has a role in select patients, early surgical treatment is favorable for good functional outcomes in high-risk patients. Advancements in imaging and operative techniques are essential to improve management protocols and long-term shoulder stability.</p>","PeriodicalId":12610,"journal":{"name":"Georgian medical news","volume":" 364-365","pages":"46-50"},"PeriodicalIF":0.0,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145274212","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"THE IMPACT OF BMAL1 GENE POLYMORPHISM ON SLEEP QUALITY IN HEALTHY CHINESE YOUTH: A GENDER-SPECIFIC ANALYSIS.","authors":"Zhengmei Fang, Xiaoling Ran, Lijun Zhu, Yingshui Yao, Yuelong Jin","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Objective: </strong>Epidemiological studies suggest that brain and muscle Arnt-like protein-1 (BMAL1) gene may impact sleep quality. However, research on this relationship among Chinese youth is limited. This study aimed to explore the relationship between BMAL1 gene polymorphism and sleep quality among Chinese youth.</p><p><strong>Methods: </strong>We employed a cross-sectional design to genotype four single-nucleotide polymorphisms (SNPs) in the BMAL1 gene using peripheral blood samples from 2715 college students. Questionnaires were used to collect demographic information about the participants, and sleep quality was evaluated using the Pittsburgh Sleep Quality Index (PSQI). Logistic regression was employed for association analysis, considering interactions between genes and the environment.</p><p><strong>Results: </strong>Overall, no significant correlation was found between BMAL1 polymorphism and sleep quality. However, quantitative trait analysis showed higher sleep latency scores in rs9633835 AA and AG genotype carriers, in the PSQI. Gender stratification analysis linked rs7107287 to sleep quality, particularly in men (OR 0.747, 95% CI, 0.5740-0.973, P=0.030, dominant model). Among men, rs7107287 AA mutant homozygous carriers had higher sleep efficiency and daytime dysfunction scores, while among women; rs9633835 AG heterozygous carriers had higher sleep latency scores. Further interaction analyses showed that sleep quality was significantly influenced by the multiplicative interaction between rs7107287 and physical exercise in men, whereas it was significantly influenced by the multiplicative interaction between rs7107287 and mental condition in women.</p><p><strong>Conclusions: </strong>These findings suggest an association between BMAL1 gene polymorphisms and sleep quality in Chinese youth, with notable gender differences. Moreover, sleep quality appears to be affected by multiple interactions between genes and the environment.</p>","PeriodicalId":12610,"journal":{"name":"Georgian medical news","volume":" 364-365","pages":"195-201"},"PeriodicalIF":0.0,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145274236","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"PREVALENCE AND ASSOCIATED RISK FACTORS OF NOCTURNAL ENURESIS AMONG CHILDREN AGED 5-18 YEARS IN ALBAHA REGION, SAUDI ARABIA.","authors":"F AlAmr, M Alghamdi, A Alghamdi, O Alghamdi, H Alghamdi, O Alghamdi, A Almimoni, A Al-Zahrani","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Background: </strong>Nocturnal enuresis (NE), or involuntary urination during sleep, is a common pediatric condition with multifactorial etiology, including genetic, developmental, and behavioral factors. Despite its high prevalence, it remains underreported and inadequately managed in many settings. This study aimed to assess the prevalence, associated risk factors, and management patterns of nocturnal enuresis among children in a defined population.</p><p><strong>Methodology: </strong>A cross-sectional study was conducted among 603 children aged 5 to 18 years. Data were collected using a structured questionnaire completed by parents, covering demographic variables, birth and health history, family background, sleep characteristics, and enuresis-related factors. Statistical analysis was performed to examine the association between nocturnal enuresis and potential risk factors, with a significance level set at p<0.05.</p><p><strong>Results: </strong>The mean age of participants was 9.1 years (SD=3.8), with a male predominance (63.5%). The prevalence of nocturnal enuresis was 35.0%. A significant association was found between enuresis and mode of delivery (p=0.027). Prematurity also showed a significant relationship (p=0.007), with enuresis most prevalent in children born before seven months of gestation (70.6%). No significant associations were observed for gender, birth order, family size, or sleep depth. Among enuretic children, 42.2% experienced bedwetting 2-4 times per week, and 60.2% had primary enuresis. A family history of enuresis was reported in 28.5% of cases, and high fluid intake before bedtime was observed in 64.9%. Although 68.2% of parents had attempted management strategies, only 47.9% reported treatment effectiveness.</p><p><strong>Conclusion: </strong>Nocturnal enuresis affects a considerable proportion of children and is associated with factors such as delivery mode and gestational age. Despite its frequency, effective treatment remains underutilized, with many parents reporting limited success. These findings underscore the need for increased awareness, timely intervention, and access to evidence-based management strategies for affected families.</p>","PeriodicalId":12610,"journal":{"name":"Georgian medical news","volume":" 364-365","pages":"258-263"},"PeriodicalIF":0.0,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145274307","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"PROGNOSTIC IMPACT OF EGFR2 AND KI-67 OVEREXPRESSION WITH DOWNREGULATION OF MIR-17 AND MIR-1307 IN FEMALE BREAST CANCER PATIENTS.","authors":"M Hassan, M Al-Askeri, N Jawad","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Background: </strong>Breast cancer has distinct epidemiological patterns and heterogeneity. EGFR2 and Ki-67 are significant in determining the progression and therapeutic response in breast cancer. Additionally, miR-17 and miR-1307 are critical regulators of tumorigenesis. Our research investigates the function of these biomarkers across breast cancer progression, diagnostic and treatment response.</p><p><strong>Methods: </strong>Fifty-Three women with breast cancer and 25 healthy women were analyzed. ELISA was used to evaluate the concentrations of EGFR2 and Ki-67. For gene expression, qPCR was used to analyze the gene expression of miR-17 and miR-1307. The diagnostic value of the proteins and miRNAs, with significance set at a p-value <0.001 for all tests.</p><p><strong>Results: </strong>The study found a significant increase in EGFR2 and Ki-67 proteins in patients compared to controls. The concentration of EGFR2 in lobular carcinoma showed a significantly higher concentration compared to Invasive Ductal Carcinoma (IDC) and Mixed carcinoma, with a p-value of 0.001. Regarding Ki-67, Lobular carcinoma had significantly higher levels compared to IDC, with a p-value of 0.03. ROC curve analysis revealed excellent diagnostic accuracy for EGFR2 and Ki-67. Positive correlation was shown between EGFR2 and Ki-67 with each other, also miR-17 and miR-1307 showed a positive correlation with other. On the other hand, a negative correlation was seen between the protein level and gene expression.</p><p><strong>Conclusion: </strong>This study found elevated EGFR2 and Ki-67 levels in breast cancer patients, indicating tumor aggressiveness, while the downregulation of miR-17 and miR-1307 suggests reduced tumor-suppressive activity. Their inverse correlation supports their use in diagnostic and treatment monitoring.</p>","PeriodicalId":12610,"journal":{"name":"Georgian medical news","volume":" 364-365","pages":"303-313"},"PeriodicalIF":0.0,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145274341","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"RADIOLOGICAL IMAGING METHODS FOR ACCURATE DIAGNOSIS OF ABDOMINAL POSTOPERATIVE COMPLICATIONS.","authors":"A Mammadov, A Mustafayev, A Aliyev","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Postoperative acute pancreatitis is a disease accompanied by severe symptoms that manifest as a systemic reaction in a certain short time. The choice of optimal methods and accurate implementation of visualization measures are of great importance in determining its severity. The aim of the study was a comparative analysis of the diagnostic efficiency of ultrasound (US) and computed tomography (CT) in detecting postoperative acute pancreatitis and complications after surgery on the gallbladder. A total of 60 patients with acute pancreatitis were included in the study. Of these, 31 (51.7%) were men and 29 (48.3%) were women. The study also included 20 patients with complications after cholecystectomy, including 11 (55.0%) men and 9 (45.0%) women. The types of operations performed were determined and postoperative symptoms were analyzed. All patients underwent CT and US. According to the obtained data, ultrasound was more effective in identifying postoperative infiltrates, and CT for timely diagnosis of abscesses, which was consistent with the results of scientific studies by foreign authors. In general, comparing the effectiveness of ultrasound and CT diagnostic methods for identifying postoperative acute pancreatitis and complications after cholecystectomy, we came to the conclusion that, when studying both postoperative complications, the effectiveness of CT in identifying the main signs was higher than that of ultrasound.</p>","PeriodicalId":12610,"journal":{"name":"Georgian medical news","volume":" 364-365","pages":"73-76"},"PeriodicalIF":0.0,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145274353","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"PROGRESS IN T-CELL IMMUNE RESEARCH ON HYPERLIPIDEMIC PANCREATITIS.","authors":"Yan Wang, Ting-Ting Wang, Chang-Sheng He","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>T cells play a significant role in the immune response of hyperlipidemic pancreatitis, with their function affected by dysregulated lipid metabolism. In acute pancreatitis, rapid T-cell activation and Th2 differentiation correlate with disease severity, involving CD4+ T cells in inflammation and IL-6 in systemic T-cell activation. Chronic pancreatitis features regulatory T-cell responses and increased central memory T cells. Hyperlipidemia exacerbates pancreatic inflammation via mechanisms like ferroptosis and fatty acid-induced acinar cell pyroptosis. T-cell-targeted immunotherapies show promise, though challenges remain. Other immune cells (e.g., macrophages), environmental factors, and calcium signaling also influence the disease.</p>","PeriodicalId":12610,"journal":{"name":"Georgian medical news","volume":" 364-365","pages":"323-326"},"PeriodicalIF":0.0,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145274367","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}