Georgian medical news最新文献

{"title":"SYNTHESIS AND SOME BIOLOGICAL PROPERTIES OF DERIVATIVES OF 2,3-DISUBSTITUTED 5,5-DIMETHYL-BENZO[H]QUINAZOLIN-4(1H)-ONES.","authors":"A Markosyan, D Alaverdieva, M Danghyan, A Mkrtchyan, L Balayan, K Hakobyan, A Geolchanyan, T Soghomonyan, V Mirzoyan","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>A series of novel 5,5-dimethyl-benzo[h]quinazolin-4(1H)-one derivatives bearing thioalkynyl and amino substituents were synthesized starting from ethyl 1-amino-3,3-dimethyl-3,4-dihydronaphthalene-2-carboxylate. The synthetic pathway involved cyclization, alkylation, and condensation reactions leading to structurally diverse quinazolinone derivatives. The structures of the synthesized compounds were confirmed by IR, ^1H and ^13C NMR spectroscopy, mass spectrometry, and thin-layer chromatography. The antioxidant activity of selected compounds was evaluated using the DPPH free radical scavenging assay, and their IC₅₀ values were determined. All tested compounds exhibited concentration-dependent antioxidant activity with IC₅₀ values ranging from 0.388 to 0.521 mM. Among them, compound XIII showed the highest radical scavenging activity, although lower than that of the reference antioxidant, ascorbic acid. Structure-activity relationship analysis indicated that the presence of amino and methoxy-substituted aromatic moieties enhanced antioxidant potential. The obtained results suggest that the synthesized benzo[h]quinazolinone represent a useful basis for further structural optimization as antioxidant agents.</p>","PeriodicalId":12610,"journal":{"name":"Georgian medical news","volume":" 376-377","pages":"139-143"},"PeriodicalIF":0.0,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149108051","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"EFFICACY OF ENDOBRONCHIAL VALVE PLACEMENT IN THE MANAGEMENT OF PULMONARY HEMORRHAGE: A COMPARATIVE STUDY.","authors":"D Tchkonia, N Gabashvili, T Mskhaladze, T Kevlishvili, M Chkonia","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Background: </strong>Pulmonary hemorrhage is a critical, life-threatening complication of diverse pulmonary pathologies, most commonly pulmonary tuberculosis, and often necessitates emergent intervention. Conventional therapeutic modalities yield inconsistent outcomes, whereas endobronchial valve (EBV) placement has emerged as a promising, minimally invasive alternative for achieving selective airway occlusion and hemostasis.</p><p><strong>Objective: </strong>To evaluate the clinical efficacy of EBV placement compared with conventional conservative management in patients presenting with pulmonary hemorrhage.</p><p><strong>Methods: </strong>A comparative cohort study was conducted at the National Center for Tuberculosis and Lung Diseases (Tbilisi, Georgia), involving 17 patients who underwent EBV placement and 26 patients treated conservatively. Outcomes assessed included hemorrhage recurrence, survival, sudden hemorrhage-related mortality, hematologic recovery, incidence of aspiration pneumonia, duration of hospitalization, and health-related quality of life (HRQoL) measured with the St. George's Respiratory Questionnaire (SGRQ).</p><p><strong>Results: </strong>Hemorrhage recurrence at 180 days was lower in the EBV group (5.9%, 1/17) than in the control group (34.6%, 9/26; χ²=4.75, p=0.042 by uncorrected χ²; p=0.071 with Yates' correction, not statistically significant at this sample size). The 180-day survival rate was higher in the EBV group (85.7%) than in controls (54.3%). No sudden hemorrhage-related deaths occurred in the EBV group, versus 5 of 26 (19.2%) in the control group, although this difference did not reach statistical significance (Fisher's exact test, p=0.139). Hematologic recovery improved significantly within the EBV group over one month (hemoglobin, hematocrit, ESR, and WBC all p<0.01), with the control group showing smaller or non-significant within-group changes. Aspiration pneumonia was less frequent in the EBV group (23.5% vs. 69.2%; χ²=6.86, p=0.0088), and mean hospital stay was shorter (13.7 vs. 51.9 days; p<0.0001). SGRQ scores improved significantly in the EBV group at 180 days (65.4→42.3, a 35.4% reduction; p<0.001), with no significant change in the control group.</p><p><strong>Conclusion: </strong>EBV placement is associated with reduced hemorrhage recurrence, improved survival, fewer complications, and better quality of life compared with conservative therapy in patients with pulmonary hemorrhage, although the recurrence and mortality comparisons should be re-verified statistically before this is presented as a definitive finding.</p>","PeriodicalId":12610,"journal":{"name":"Georgian medical news","volume":" 376-377","pages":"38-42"},"PeriodicalIF":0.0,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149108193","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"MANAGEMENT OF PERIOPERATIVE BLEEDING IN PATIENTS WITH PLATELET HYPOAGGREGABILITY DURING DENTOALVEOLAR SURGERY: CLINICAL OUTCOMES AND THERAPEUTIC APPROACHES.","authors":"S Gashi, E Mulaj, N Rugova, S Dvojakovska, F Koneski","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Background: </strong>Perioperative bleeding is a clinically important complication in patients with platelet hypoaggregability undergoing tooth extraction and minor dentoalveolar surgery. Impaired platelet aggregation may result in prolonged bleeding despite normal routine coagulation tests.</p><p><strong>Aim: </strong>This study aimed to evaluate perioperative bleeding outcomes and the effectiveness of a standardized tranexamic acid (TXA)-based protocol in patients with laboratory-confirmed platelet hypoaggregability undergoing dentoalveolar surgical procedures.</p><p><strong>Material and methods: </strong>This retrospective observational clinical study analyzed data from 64 patients with laboratory-confirmed platelet hypoaggregability and 64 healthy controls treated between January 2019 and December 2024 at the University Clinic for Maxillofacial Surgery, Skopje. Patients receiving chronic anticoagulant or antiplatelet therapy were not included in the present analysis. Platelet aggregation was assessed using ADP, collagen and ristocetin. Patients with platelet hypoaggregability received intravenous TXA at a dose of 10 mg/kg approximately 30 minutes before surgery, combined with local hemostatic measures.</p><p><strong>Results: </strong>Patients with platelet hypoaggregability demonstrated prolonged bleeding history and significantly reduced platelet aggregation values. Mean ADP-, ristocetin- and collagen-induced aggregation values were 36.9±13.3%, 61.4±14.0% and 49.1±15.5%, respectively. Bleeding duration was inversely correlated with ADP (r=-0.346, p=0.005) and ristocetin values (r=-0.275, p=0.028). Following TXA administration, no moderate or severe postoperative bleeding was recorded, and complete hemostasis was achieved in 98.4% of cases.</p><p><strong>Conclusion: </strong>Platelet hypoaggregability is an important risk factor for prolonged post-extraction bleeding. A standardized perioperative protocol based on platelet aggregation assessment, intravenous TXA at 10 mg/kg and local hemostatic measures appears safe and effective for dentoalveolar surgery in this patient group.</p>","PeriodicalId":12610,"journal":{"name":"Georgian medical news","volume":" 376-377","pages":"209-214"},"PeriodicalIF":0.0,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149108119","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"EXPLORING THE SATISFACTION OF NEWLY HIRED NURSES USING AN EVIDENCE-BASED, PERSONALIZED ONBOARDING PROGRAM: A CROSS-SECTIONAL ANALYSIS.","authors":"A Articulo, R Cuevas, H Al-Najjar, R Alkhuraif, R Aburmeishan, A Almatrody","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Purpose: </strong>To examine the satisfaction of newly hired nurses with an evidence-based, 90-day onboarding program, and to explore how satisfaction relates to factors that may bear on future workforce retention.</p><p><strong>Methods: </strong>We conducted a cross-sectional assessment of newly hired nurses at the Qassim University Medical Center (QUMC) across 2023. Nurses were subjected to a 90-day onboarding program, comprised of three distinct stages. Participants' satisfaction was measured using a literature validated questionnaire. Differences in satisfaction across nurses' sociodemographic characteristics were analyzed using SPSS version 28. A p-value <0.05 was considered statistically significant.</p><p><strong>Results: </strong>A total of 109 newly hired nurses were included in the final analysis. Overall, participants reported high overall satisfaction with the program (8.18±1.72). Participants' self-perceptions of the program's effectiveness in building communication skills (r: 0.483), elucidating policies and regulations (r: 0.484), and improving the understanding of interdepartmental responsibilities (r: 0.497) were the strongest factors associated with increased overall satisfaction. Self-perceived satisfaction scores across the questionnaire's 30 items were statistically indifferent between genders of nurses. Among different departments, nurses in the ER had relatively the lowest overall satisfaction. Similarly, nurses of Arab origin demonstrated lower satisfaction compared to their non-Arab counterparts.</p><p><strong>Conclusion: </strong>An evidence-based 90-day onboarding program was associated with a high sense of fitness and belonging among newly hired nurses. Moreover, the findings shed light on the transitional shock experienced when nurses start their practical careers after graduation. As this was a cross-sectional study, these associations should not be interpreted as causal, and it remains unclear whether high rates of satisfaction will translate into higher employee retention in the long term.</p>","PeriodicalId":12610,"journal":{"name":"Georgian medical news","volume":" 376-377","pages":"215-222"},"PeriodicalIF":0.0,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149108144","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"IMPACT OF THE COVID-19 PANDEMIC ON THE SEVERITY AND OUTCOMES OF GUNSHOT INJURIES.","authors":"G Datumyan, K Shaboyan, A Muradyan, E Shaboyan, A Galstyan, A Badalyan, M Sargsyan","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Objective: </strong>To evaluate the impact of COVID-19 infection on injury severity, clinical course, complications, and hospital outcomes in patients with gunshot injuries.</p><p><strong>Materials and methods: </strong>This retrospective descriptive-analytical study was conducted at the Central Clinical Military Hospital of the Ministry of Defence of the Republic of Armenia. The study included 80 male patients with gunshot injuries who were hospitalized during 2020. Of these, 55 (68.8%) patients were COVID-19-positive and 25 (31.2%) were COVID-19-negative. Injury severity was assessed using the Injury Severity Score (ISS) and the Glasgow Coma Scale (GCS). The rates of intensive care unit (ICU) admission, requirement for mechanical ventilation, length of hospital stay, complications, and in-hospital mortality were analyzed.</p><p><strong>Results: </strong>The mean ISS was significantly higher in COVID-19-positive patients than in COVID-19-negative patients (22.8±7.4 vs. 15.2±5.8, p<0.01). Conversely, the mean GCS score was significantly lower in the COVID-19-positive group (12.9±2.5 vs. 14.6±1.8, p<0.05). ICU admission was required in 43.6% of COVID-19-positive patients compared with 16.0% of COVID-19-negative patients. Mechanical ventilation was required in 21.8% and 8.0% of patients, respectively. The incidence of complications was 29.1% in the COVID-19-positive group and 12.0% in the COVID-19-negative group. In-hospital mortality was 10.9% and 4.0%, respectively. Correlation analysis demonstrated a significant positive association between ISS and length of hospital stay (r=0.61, p<0.001), as well as between ISS and mortality (r=0.58, p<0.001).</p><p><strong>Conclusion: </strong>COVID-19 infection in patients with gunshot injuries is associated with greater injury severity, an increased need for intensive care, a higher incidence of complications and mortality, and prolonged hospitalization. The coexistence of COVID-19 infection and gunshot trauma may be regarded as a mutually aggravating clinical condition that requires early diagnosis, intensive monitoring, and a multidisciplinary treatment approach.</p>","PeriodicalId":12610,"journal":{"name":"Georgian medical news","volume":" 376-377","pages":"78-84"},"PeriodicalIF":0.0,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149108191","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"PD-L1 EXPRESSION AND SERUM CA125: CLINICOPATHOLOGICAL CORRELATIONS IN HIGH-GRADE SEROUS OVARIAN CARCINOMA.","authors":"T Kosayeva, A Amiraslanov, H Muradov, A Gaziyev, B Abbasov","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Introduction: </strong>Programmed death-ligand 1 (PD-L1) has emerged as an important immune checkpoint biomarker in ovarian cancer. However, its relationship with serum cancer antigen 125 (CA125), a routinely used biomarker for disease monitoring, remains insufficiently investigated, particularly in patients with high-grade serous ovarian carcinoma (HGSC).</p><p><strong>Aim: </strong>To evaluate the association between PD-L1 expression and serum CA125 levels in patients with high-grade serous ovarian carcinoma and to investigate the relationships of PD-L1 expression with age and FIGO stage.</p><p><strong>Materials and methods: </strong>This retrospective case-control study included 69 women treated for ovarian tumors between 2018 and 2025, comprising 42 patients with histologically confirmed HGSC and 27 patients with benign epithelial ovarian tumors serving as controls. PD-L1 expression was assessed immunohistochemically using the VENTANA PD-L1 (SP263) assay and evaluated by the Tumor Proportion Score (TPS), with positivity defined as TPS ≥1%. Serum CA125 levels were categorized as ≤35 U/mL or >35 U/mL. Statistical analyses included Pearson's chi-square test, Fisher's exact test, and odds ratios (ORs) with 95% confidence intervals (CIs), with statistical significance defined as p<0.05.</p><p><strong>Results: </strong>PD-L1 expression was detected in 17 (24.6%) of the 69 patients, including 16/42 (38.1%) patients with HGSC and 1/27 (3.7%) controls. PD-L1 positivity was significantly more frequent in HGSC than in benign tumors (OR=16.0; 95% CI 1.97-129.64; p=0.0012). Within the HGSC cohort, CA125 >35 U/mL was observed in 13/16 (81.3%) PD-L1-positive and 22/26 (84.6%) PD-L1-negative patients. No significant association was identified between CA125 category and PD-L1 expression (OR=0.79; 95% CI 0.15-4.09; Fisher's exact p=1.000). No statistically significant associations were observed between PD-L1 expression and age (p=0.454) or FIGO stage (p=0.978).</p><p><strong>Conclusion: </strong>PD-L1 expression was significantly more frequent in HGSC than in benign epithelial ovarian tumors. However, the initially observed association between PD-L1 expression and elevated serum CA125 was not confirmed when the analysis was restricted to the 42-patient HGSC cohort. Larger studies are needed to clarify the relationship between PD-L1 and CA125 within HGSC.</p>","PeriodicalId":12610,"journal":{"name":"Georgian medical news","volume":" 376-377","pages":"274-280"},"PeriodicalIF":0.0,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149107537","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"PERCEPTIONS AND PRACTICES OF HEALTHCARE PROVIDERS IN MATERNAL MORTALITY AND STILLBIRTH PREVENTION AND MANAGEMENT: INSIGHTS FROM LEJWELEPUTSWA DISTRICT.","authors":"Simbarashe Magaisa","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Aim of study: </strong>Maternal mortality and stillbirth remain major public health challenges in South Africa, particularly in rural and peri-urban districts such as Lejweleputswa. This study explored healthcare providers' perceptions and practices regarding the prevention and management of maternal mortality and stillbirth, with the aim of identifying factors influencing maternal and perinatal outcomes.</p><p><strong>Material and methods: </strong>A qualitative descriptive design was employed. Semi-structured interviews were conducted with professional nurses, midwives, clinic managers, maternal unit managers, and local area managers/team leaders for community healthcare workers working in public healthcare facilities across the Lejweleputswa District. Data were collected through individual interviews and analyzed using qualitative content analysis to identify key themes related to maternal mortality and stillbirth prevention and management.</p><p><strong>Results: </strong>Stillbirth was perceived as largely preventable; however, barriers included staff shortages, limited resources, inadequate infrastructure, delayed referrals, high workloads, late antenatal booking, low maternal health literacy, and cultural beliefs. Participants remained committed to improving outcomes and recommended workforce strengthening, improved referral systems, and psychosocial support.</p><p><strong>Conclusions: </strong>Maternal mortality and stillbirth are shaped by health system, clinical, and community factors. Integrated, context-specific interventions are required to improve maternal and neonatal outcomes and align with Sustainable Development Goals 3.1 and 3.2.</p>","PeriodicalId":12610,"journal":{"name":"Georgian medical news","volume":" 376-377","pages":"356-363"},"PeriodicalIF":0.0,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149107588","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"ACE I/D AND NOS3 G894T POLYMORPHISMS AND CARDIOVASCULAR ADAPTATION PROFILES IN ADOLESCENT FOOTBALL PLAYERS.","authors":"A Ruziyeva, O Khamidov, S Murodqosimov, B Doniyorov, F Khalimova, I Marwan","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Aim: </strong>To assess the associations of ACE I/D (rs4646994) and NOS3 G894T (rs1799983) polymorphisms with cardiovascular adaptation profiles, autonomic regulation, exercise tolerance and responsiveness to individualized training-load correction in adolescent football players.</p><p><strong>Materials and methods: </strong>This controlled comparative study with an observational pre-post follow-up component included 228 male adolescents aged 13-17 years: 168 football players with at least two years of regular training and 60 non-athlete peers. The examination included anthropometry, body composition assessment, resting and exercise electrocardiography, echocardiography, short-term heart rate variability (HRV) analysis, submaximal bicycle ergometry with PWC170 and estimated VO2max, heart-rate recovery (HRR), and genotyping of ACE I/D and NOS3 G894T polymorphisms. The 3-month individualized training-load correction was analyzed as a non-randomized observational component; therefore, its results were interpreted as post-correction dynamics rather than as definitive evidence of causal efficacy.</p><p><strong>Results: </strong>Football players had a lower resting heart rate than controls (58.6±6.8 vs 72.4±7.5 beats/min; p<0.001), higher PWC170 (196±32.6 vs 142±28.4 W; p<0.001), higher relative PWC170 (3.42±0.52 vs 2.40±0.46 W/kg; p<0.001), higher estimated VO2max (54.0±4.8 vs 42.5±5.2 ml/kg/min; p<0.001) and faster HRR1 (43.6±11.3 vs 25.3±10.4 beats/min; p<0.001). ACE and NOS3 genotype distributions were comparable between football players and controls. Within the athletic cohort, ACE DD and, to a lesser extent, NOS3 T-allele carriage were associated with lower SDNN, RMSSD and pNN50, higher LF/HF and less favorable diastolic indices. After three months of individualized training-load correction, positive HRV and diastolic dynamics were observed mainly in favorable and intermediate genetic profiles, whereas the unfavorable profile showed limited changes.</p><p><strong>Conclusion: </strong>ACE I/D and NOS3 G894T polymorphisms should not be interpreted as markers of football participation or selection. They may be considered exploratory modifiers of autonomic reserve, diastolic adaptation and response to individualized training-load monitoring. Integration of genotyping with ECG, echocardiography, HRV, HRR and PWC170 appears promising for personalized monitoring in adolescent football players but requires further external validation. The results of the dynamic stage should be interpreted as observational, since the training-load correction was not randomized.</p>","PeriodicalId":12610,"journal":{"name":"Georgian medical news","volume":" 376-377","pages":"281-288"},"PeriodicalIF":0.0,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149108067","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"THE ROLE OF CELL THERAPY IN THE COMPREHENSIVE TREATMENT OF CHRONIC HEPATITIS C-RELATED LIVER CIRRHOSIS.","authors":"A Astrakhanov, A Amanzholkyzy, S Saparbayev, M Kurmangazin, A Iskakova, G Nurlanova","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Background: </strong>Despite the high efficacy of direct-acting antiviral (DAA) therapy for chronic hepatitis C virus (HCV) infection, a considerable proportion of patients continue to exhibit significant structural liver damage, including advanced fibrosis and cirrhosis. Therefore, the search for additional therapeutic approaches aimed at enhancing liver regeneration and improving hepatic functional status remains highly relevant.</p><p><strong>Objective: </strong>To evaluate the clinical efficacy of fetal stem hepatocyte transplantation as part of a comprehensive treatment strategy for liver cirrhosis associated with chronic hepatitis C.</p><p><strong>Materials and methods: </strong>A prospective comparative study was conducted involving 106 patients with HCV-related liver cirrhosis. Patients were divided into two comparable groups of 53 individuals each. The main group received direct-acting antiviral therapy combined with fetal stem hepatocyte transplantation, whereas the control group received antiviral therapy alone. All participants underwent comprehensive clinical, laboratory, and instrumental examinations, including transient liver elastography. Treatment efficacy was assessed using changes in Child-Pugh and MELD scores over a 12-month follow-up period. Statistical analysis was performed using parametric and non-parametric methods.</p><p><strong>Results: </strong>Baseline Child-Pugh and MELD scores did not differ significantly between the groups. After 12 months of follow-up, the Child-Pugh score was significantly lower in the main group compared with the control group (7.11±0.91 vs. 7.81±1.13 points, respectively; p=0.002). Similarly, the MELD score was significantly lower in the main group than in the control group (17.9±2.11 vs. 19.1±2.21 points, respectively; p=0.004). Repeated-measures analysis of variance demonstrated a statistically significant effect of both follow-up duration and treatment modality on Child-Pugh (η²=35.9% and η²=25.0%, respectively) and MELD scores (η²=23.3% and η²=18.2%, respectively; p<0.001).</p><p><strong>Conclusion: </strong>The addition of fetal stem hepatocyte transplantation to standard antiviral therapy contributes to a more pronounced improvement in liver functional status in patients with HCV-related cirrhosis compared with antiviral therapy alone. These findings support the potential role of cell-based therapies as a promising adjunctive treatment option for liver cirrhosis and highlight the need for further studies to evaluate their long-term efficacy and safety.</p>","PeriodicalId":12610,"journal":{"name":"Georgian medical news","volume":" 376-377","pages":"364-370"},"PeriodicalIF":0.0,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149108112","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"THREE-DIMENSIONAL CT-BASED MORPHOMETRIC ASSESSMENT OF THE MAXILLARY SINUS.","authors":"N Yurevych, O Sazonova, I Kachailo, Yu Hnidyk, P Pokotylo, M Podolyuk, N Blyschak, M Mykhalevych, V Zherebkin, O Kosynskyi, V Alieksieieva","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Introduction: </strong>The maxillary sinus demonstrates marked anatomical variability, which has important implications for sinus ventilation, surgical access, and implant planning. While computed tomography (CT) remains the standard modality for anatomical assessment, conventional two-dimensional measurements may inadequately represent complex three-dimensional structures.</p><p><strong>Aim: </strong>The aim of our study was to perform a three-dimensional CT-based morphometric analysis of the maxillary sinus using 3D Slicer software and classical statistical methods, focusing on volumetric characteristics, wall thickness, bone density, and their interrelationships.</p><p><strong>Materials and methods: </strong>CT datasets of adult subjects without sinonasal pathology were analyzed. Three-dimensional segmentation and reconstruction of the maxillary sinus were performed using 3D Slicer. Linear dimensions, sinus volume, wall thickness, and bone density were measured. Statistical analysis included descriptive statistics, Pearson correlation analysis, and Bland-Altman agreement analysis.</p><p><strong>Results: </strong>Maxillary sinus volume demonstrated strong correlations with wall thickness parameters, particularly the superior and medial walls. Three-dimensional measurements revealed systematic differences compared to planar CT measurements, with higher and more consistent wall thickness values. Bone density measurements showed stable distributions across sinus walls.</p><p><strong>Conclusions: </strong>Three-dimensional CT-based analysis using 3D Slicer provides a reliable and anatomically accurate approach for evaluating maxillary sinus morphology. Classical statistical analysis confirms meaningful structural relationships that are not fully captured by two-dimensional measurements.</p>","PeriodicalId":12610,"journal":{"name":"Georgian medical news","volume":" 376-377","pages":"349-355"},"PeriodicalIF":0.0,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149108046","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}