Angewandte Chemie International Edition最新文献_第8页

Dual-Locked Polymeric STING Nano-Agonist/Sonosensitizer Augments Spatiotemporally Controlled Cancer Sono-Immunotherapy. 双锁聚合物STING纳米激动剂/声敏剂增强了时空控制的癌症声免疫治疗。

IF 16.6 1区化学

Angewandte Chemie International Edition Pub Date : 2025-09-07 DOI: 10.1002/anie.202514516

Yiwen Jia,Wencong Jia,Zhengqi Tang,Ye Wu,Wei Yang,Weifan Ye,Hongze Ren,Yujie Xie,Yu Chen,Meihua Yu

{"title":"Dual-Locked Polymeric STING Nano-Agonist/Sonosensitizer Augments Spatiotemporally Controlled Cancer Sono-Immunotherapy.","authors":"Yiwen Jia,Wencong Jia,Zhengqi Tang,Ye Wu,Wei Yang,Weifan Ye,Hongze Ren,Yujie Xie,Yu Chen,Meihua Yu","doi":"10.1002/anie.202514516","DOIUrl":"https://doi.org/10.1002/anie.202514516","url":null,"abstract":"The stimulator of interferon genes (STING) pathway is a central target in cancer immunotherapy, but current STING agonist therapies lack precision control, leading to suboptimal therapeutic outcomes and systematic adverse effects. Herein, we engineered a dual-locked immuno-polymeric nanoplatform (IPN) with precise spatiotemporal control over the release of STING agonists to enhance cancer immunotherapy. This platform, constructed from biocompatible poly(β-amino esters) (PBAE), incorporates the STING agonist (MSA-2) covalently linked via ester bonds, which is co-assembled with a sonosensitizer. Upon activation by ultrasound and natural esterase enzyme, IPN significantly enhances the localized release of MSA-2 within the tumor. Alongside, this platform augments the generation of toxic radicals, leading to the spread of tumor antigens and immunogenic biomolecules, subsequently initiating a high magnitude of antigen-specific T cells for tumor eradication. The multifaceted advantages of ultrasound and enzymes synergistically enhance the physical contact and spatial organization of immune-related reactants as well as chemical bioprocesses. This dual-locked IPN platform demonstrates an eight fold greater tumor inhibition compared to single-locked counterparts and a four fold enhancement over the summation effect, highlighting a safer and more effective paradigm for cancer immunotherapy.","PeriodicalId":125,"journal":{"name":"Angewandte Chemie International Edition","volume":"30 1","pages":"e202514516"},"PeriodicalIF":16.6,"publicationDate":"2025-09-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145008773","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Chemically Stable Tetrazine-Based Porous Organic Cages with Post-Synthetic Modification via Inverse-Electron-Demand Diels–Alder Reactions for SF6/N2 and CO2/N2 Separation 化学稳定的四氮基多孔有机笼，通过反电按需Diels-Alder反应进行合成后改性，用于SF6/N2和CO2/N2分离

IF 16.6 1区化学

Angewandte Chemie International Edition Pub Date : 2025-09-07 DOI: 10.1002/anie.202512561

Ju Yang, Saisai Yu, Wendi Zhang, Siyuan Yang, Dingyue Hu, Yutao Guan, Hongqing Li, Prof. Ming Liu

引用次数: 0

Self-Assembled Polypseudorotaxanes Crosslinked by Dynamic Disulfide Bonds as Modular Functionalization for Thiophilic Metal Nanoparticles 动态二硫键交联的自组装聚聚环烷作为亲硫金属纳米颗粒的模块化功能化

IF 16.6 1区化学

Angewandte Chemie International Edition Pub Date : 2025-09-07 DOI: 10.1002/anie.202515585

Xiang Xu, Bing Zan, Yuanyang Xie, Pornpilat Akapan, Marcelo da Silva, Miao Zhao, Erol Hasan, Aliaksandra Rakovich, Driton Vllasaliu, Gregory N. Smith, Gustavo González-Gaitano, Graeme Hogarth, Cécile A. Dreiss

引用次数: 0

Catalysis of Radical Coupling Reaction via Synergistic Action of Oriented External Electric Field and Light Irradiation. 定向外电场与光辐照协同作用对自由基偶联反应的催化作用。

IF 16.6 1区化学

Angewandte Chemie International Edition Pub Date : 2025-09-07 DOI: 10.1002/anie.202514789

Hefa Feng,Fenglu Hu,Xin Zuo,Haoyu Wang,Ramya Emusani,Guangwu Li,Weiwei Niu,Adila Adijiang,Wanghong Deng,Lichuan Chen,Dong Xiang

{"title":"Catalysis of Radical Coupling Reaction via Synergistic Action of Oriented External Electric Field and Light Irradiation.","authors":"Hefa Feng,Fenglu Hu,Xin Zuo,Haoyu Wang,Ramya Emusani,Guangwu Li,Weiwei Niu,Adila Adijiang,Wanghong Deng,Lichuan Chen,Dong Xiang","doi":"10.1002/anie.202514789","DOIUrl":"https://doi.org/10.1002/anie.202514789","url":null,"abstract":"Radical coupling reactions have been widely used in the synthesis of complex organic molecules, materials science, and drug research. However, restricted conditions or special catalysts are required to overcome the energy barrier and trigger the coupling reaction efficiently. In this study, we provide experimental evidence that the C─N radical coupling reactions can be significantly accelerated by an oriented external electric field (OEEF) under synchronous UV irradiation without a catalyst. By repeatedly forming thousands of single-molecular junctions with reactant molecules in nonpolar solvents under a bias voltage, a new conductance plateau was observed upon UV irradiation, which was completely absent in polar solvents owing to the electrical shielding effect. This finding indicates that the radicals generated under light irradiation can timely participate in the coupling reaction under the in situ action of OEEF, leading to the high-efficiency generation of the C─N radical coupling product, which was confirmed by the measured electron paramagnetic spectrum and high-resolution mass spectrometry. With the assistance of theoretical calculations, the underlying mechanism was further revealed, i.e., OEEF can significantly decrease the reaction barrier and facilitate the intermolecular hydrogen atom transfer (HAT). This study provides a catalyst-free paradigm for high-efficiency radical reactions.","PeriodicalId":125,"journal":{"name":"Angewandte Chemie International Edition","volume":"24 1","pages":"e202514789"},"PeriodicalIF":16.6,"publicationDate":"2025-09-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145008772","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Lithium-Mediated Hydrochloric Acid Dissolution: Enabling Clean and Efficient Recovery of Palladium from Spent Catalysts by Electrodeposition 锂介导的盐酸溶解：电沉积法从废催化剂中清洁高效地回收钯

IF 16.6 1区化学

Angewandte Chemie International Edition Pub Date : 2025-09-07 DOI: 10.1002/anie.202512532

Dengjie Yan, Muwen Chen, Guoqing Zhang, Lingxin Kong, Bin Yang

引用次数: 0

Engineering Covalent and Noncovalent Interface Synergy in MXenes for Ultralong-life and Efficient Energy Storage. MXenes的工程共价和非共价界面协同作用用于超长寿命和高效储能。

IF 16.6 1区化学

Angewandte Chemie International Edition Pub Date : 2025-09-07 DOI: 10.1002/anie.202513390

Mengting Cheng,Wei Guo,Wanbin Dang,Jinxin Wang,Qiuyu Zhang

{"title":"Engineering Covalent and Noncovalent Interface Synergy in MXenes for Ultralong-life and Efficient Energy Storage.","authors":"Mengting Cheng,Wei Guo,Wanbin Dang,Jinxin Wang,Qiuyu Zhang","doi":"10.1002/anie.202513390","DOIUrl":"https://doi.org/10.1002/anie.202513390","url":null,"abstract":"MXenes serve as pivotal candidates for pseudocapacitive energy storage owing to sound proton/electron-transport capability and tunable topology. However, the metastable surface terminal properties and the progressive oxidation leads to drastic capacity fading, posing significant challenges for sustainable energy applications. Here, with the aramid nanofiber as the interface mediator, we engineer the thermal reconstruction of MXenes to synergistically introduce interfacial covalent and noncovalent interactions, resulting in a high specific capacitance of 531.9 F g-1 and a capacity retention of 92.2% after 180, 000 cycles. In-situ heating transmission electron microscopy observations demonstrate the formation of ultrafine mesopores with interfacial reconstitution for mass transport intensification. Theoretical calculations indicate electronic accumulation adjacent to the covalent bonds, endowing the heterogeneous interface with fast electronic conduction capability and favorable adsorption of H+. In addition, the dual modification improves the oxidation energy barrier of MXenes to TiO2, resulting in a thermodynamically promoted and sustainable storage microenvironment. Our research emphasizes the synergistic mechanism of noncovalent interactions and covalent bonding toward an optimal reaction interface, which breaks the trade-off of MXenes between the reactivity and stability for energetic energy storage.","PeriodicalId":125,"journal":{"name":"Angewandte Chemie International Edition","volume":"40 1","pages":"e202513390"},"PeriodicalIF":16.6,"publicationDate":"2025-09-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145008769","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Activity-Based Ubiquitin Probes Capture the Sulfenylated State of Deubiquitinases 基于活性的泛素探针捕获去泛素酶的磺化状态

IF 16.6 1区化学

Angewandte Chemie International Edition Pub Date : 2025-09-07 DOI: 10.1002/anie.202512311

Zian Chen, Guorui Li, Jiahao Zhang, Xiaoyu Xu, Qipeng Yan, Qingyu Wang, Qinfeng Zhang, Jing Huang

引用次数: 0

Quantitative Super-Resolution Imaging of On-Origami DNA Conformation and Reactivity Under Electric Fields. 电场作用下非折纸DNA构象和反应性的定量超分辨率成像。

IF 16.6 1区化学

Angewandte Chemie International Edition Pub Date : 2025-09-07 DOI: 10.1002/anie.202508159

Zhongchao Jin,Yiyang Zeng,Xiaodong Xie,Zheze Dai,Yao Xie,Jianlei Shen,Xiaoguo Liu,Jiang Li,Lihua Wang,Qian Li,Fei Wang,Chunhai Fan,Hui Lv

{"title":"Quantitative Super-Resolution Imaging of On-Origami DNA Conformation and Reactivity Under Electric Fields.","authors":"Zhongchao Jin,Yiyang Zeng,Xiaodong Xie,Zheze Dai,Yao Xie,Jianlei Shen,Xiaoguo Liu,Jiang Li,Lihua Wang,Qian Li,Fei Wang,Chunhai Fan,Hui Lv","doi":"10.1002/anie.202508159","DOIUrl":"https://doi.org/10.1002/anie.202508159","url":null,"abstract":"Self-assembled DNA nanostructures have been popularly used to develop DNA-based electrochemical sensors by exploiting the nanoscale positioning capability of DNA origami. However, the impact of the electric field on the structural stability of the DNA origami framework and the activity of carried DNA probes remains to be explored. Herein, we employ DNA origami as structural frameworks for reversible DNA hybridization, and develop a single-molecule fluorescence imaging method to quantify electric field effects on DNA conformation and hybridization properties at the single-molecule level. Through single-molecule temporal kinetic analysis of hybridization events occurring on individual DNA origami, we systematically determine the regulation patterns of applied potential and scanning duration on the activity of DNA probes. Optical super-resolution reconstruction of probe sites reveals electric field-induced structural relaxation in DNA frameworks. This approach not only provides insights into electrochemical DNA sensing devices, but also lays the foundation for developing hybrid electrical-optical analysis at the single-molecule level.","PeriodicalId":125,"journal":{"name":"Angewandte Chemie International Edition","volume":"213 1","pages":"e202508159"},"PeriodicalIF":16.6,"publicationDate":"2025-09-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145008767","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Oxygen-Tolerant, Red Light-Driven Controlled Synthesis of Easily Degradable and High Molecular Weight α-Lipoic Acid-Vinyl Copolymers 易降解高分子量α-硫辛酸-乙烯基共聚物的耐氧红光控制合成

IF 16.6 1区化学

Angewandte Chemie International Edition Pub Date : 2025-09-07 DOI: 10.1002/anie.202516164

Ivan O. Levkovsky, Lucca Trachsel, Hironobu Murata, Krzysztof Matyjaszewski

引用次数: 0

Emphasizing a-parameter Expansion in Lattice Distortions of Disordered Rock Salt Li3V2O5: From Crystallographic Design to Feasible Large-Scale Chemical Lithiation. 强调无序岩盐Li3V2O5晶格畸变的a参数展开：从晶体学设计到可行的大规模化学锂化。

IF 16.6 1区化学

Angewandte Chemie International Edition Pub Date : 2025-09-07 DOI: 10.1002/anie.202512467

Lingfeng Shi,Ziwei Liu,Jiale An,Ke Li,Yehang Dou,Shu Guo,Yulin Ma,Geping Yin,Weiwei Meng,Hua Huo

{"title":"Emphasizing a-parameter Expansion in Lattice Distortions of Disordered Rock Salt Li3V2O5: From Crystallographic Design to Feasible Large-Scale Chemical Lithiation.","authors":"Lingfeng Shi,Ziwei Liu,Jiale An,Ke Li,Yehang Dou,Shu Guo,Yulin Ma,Geping Yin,Weiwei Meng,Hua Huo","doi":"10.1002/anie.202512467","DOIUrl":"https://doi.org/10.1002/anie.202512467","url":null,"abstract":"Disordered rock-salt Li3V2O5 (DRX-LVO) anode exhibits distinctive 3D Li+ percolation transport networks, which offers the unique advantage for ultra-charging. However, the existing chemical lithiation preparation routes not only pose safety risks due to the use of highly reactive reagents but also inevitably result in products with poor crystallinity. Investigating the origin, impact, and strategies for crystallinity degradation is pivotal for advancing the industrialization of chemical lithiation. To address the safety issue, different lithiation reagents were evaluated from the perspective of lone electron activity, and lithium naphthalene was identified as an ideal reagent balancing safety and efficiency. Through DFT calculations, the mechanism underlying different types of distortions in the DRX system was decoupled while the distinct effects of a/b/c-axis variations on migration energy barriers were elucidated. Guided by theoretical insights, the a-axis was nominated as the critical parameter for enhancing electrochemical performance, leading to the development of Li3V2O5 with elongated a-axis dimensions that exhibit significantly improved rate capabilities (80 mAh g-1 at 20 A g-1). This study elucidates the distortion mechanisms via exploring the correlation among chemical lithiation feasibility, lattice tuning and kernel parameter confirmation, as well as fast-charging behavior, shedding light on precise crystallographic design on high-performance fast-charging anode.","PeriodicalId":125,"journal":{"name":"Angewandte Chemie International Edition","volume":"28 1","pages":"e202512467"},"PeriodicalIF":16.6,"publicationDate":"2025-09-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145008768","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0