Angewandte Chemie International Edition最新文献

Discovery of Perilloxazole Pseudo-Natural Products Yields a New Sterol Biosynthesis Inhibitor Chemotype. 一种新的甾醇生物合成抑制剂化学型的发现。

IF 16.6 1区化学

Angewandte Chemie International Edition Pub Date : 2026-04-29 DOI: 10.1002/anie.5776539

Peng Lei,Yuge Hu,Tiantian Sun,Yanyan Qu,Hanxiao Yuan,Yanqing Gao,Jianqiang Miao,Xingxing Lu,Xili Liu

{"title":"Discovery of Perilloxazole Pseudo-Natural Products Yields a New Sterol Biosynthesis Inhibitor Chemotype.","authors":"Peng Lei,Yuge Hu,Tiantian Sun,Yanyan Qu,Hanxiao Yuan,Yanqing Gao,Jianqiang Miao,Xingxing Lu,Xili Liu","doi":"10.1002/anie.5776539","DOIUrl":"https://doi.org/10.1002/anie.5776539","url":null,"abstract":"Pseudo-natural products (PNPs) are new arrangements of natural product (NP) fragments, creating chemical spaces that extend beyond those explored by nature and are unattainable via known biosynthetic pathways. Herein, we establish the design principles for agrochemically-active PNPs based on characteristic pesticide features. We systematically applied this strategy to discover PNP agricultural fungicides, opening up a broad new avenue for developing novel NP-derived pesticides. We designed perilloxazole PNPs by integrating cyclohexene and isoxazoline fragments. Cheminformatics analysis demonstrates that perilloxazole PNPs combine the advantageous properties of NPs and pesticides. Biological evaluation reveals that perilloxazole represents a new chemotype of sterol biosynthesis inhibitor with low toxicity to non-target organisms, providing a foundation for the discovery of superior green fungicides. Perilloxazole PNPs exhibit notable control efficacy against major crop diseases that cause severe agricultural losses, holding broad application prospects and high market potential.","PeriodicalId":125,"journal":{"name":"Angewandte Chemie International Edition","volume":"122 1","pages":"e5776539"},"PeriodicalIF":16.6,"publicationDate":"2026-04-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147754901","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Transforming Interfacial Reactivity Into Stability for Durable High-Current Solid-State Sodium Batteries. 将界面反应性转化为耐用大电流固态钠电池的稳定性。

IF 16.6 1区化学

Angewandte Chemie International Edition Pub Date : 2026-04-29 DOI: 10.1002/anie.5003701

Le Xiang,Fayang Guan,Hengxiang Wang,Xiaoxiao Zhu,Bing Cheng,Chuanqiang Wu,Aoran Fan,Xiaodi Ren,Xiaowen Zhan,Lingyun Zhu

{"title":"Transforming Interfacial Reactivity Into Stability for Durable High-Current Solid-State Sodium Batteries.","authors":"Le Xiang,Fayang Guan,Hengxiang Wang,Xiaoxiao Zhu,Bing Cheng,Chuanqiang Wu,Aoran Fan,Xiaodi Ren,Xiaowen Zhan,Lingyun Zhu","doi":"10.1002/anie.5003701","DOIUrl":"https://doi.org/10.1002/anie.5003701","url":null,"abstract":"Interfacial instability remains the key obstacle to reliable oxide-based solid-state batteries (SSBs). Here we demonstrate a monolithic, self-regulating mixed ionic-electronic conducting (MIEC) interface that transforms interfacial reactivity into long-term stability in SSBs. Introducing cobalt into NASICON-type Na3Zr2Si2PO12 (NZSP) yields a dual-phase NaCoPO4/NZSP composite electrolyte, which evolves during cycling into a nanoporous interphase containing Co nanoparticles embedded in NASICON matrix. This reaction‑derived interphase enlarges the active area, homogenizes ion flux, and guides uniform sodium deposition. Extending this concept to a tri-layer electrolyte architecture with Co-modified outer layers and pristine NZSP core enables a self-limiting reaction stabilizing both interfaces. Optimized cells achieve a critical current density of 7.3 mA cm-2 at 60°C and sustain symmetric-cell cycling over 3000 h at 1 mA cm-2. Full cells deliver >99% capacity retention over 1200 cycles at 2 C. This work establishes interfacial chemistry as a tunable design principle for durable, high-current solid-state metal batteries.","PeriodicalId":125,"journal":{"name":"Angewandte Chemie International Edition","volume":"5 1","pages":"e5003701"},"PeriodicalIF":16.6,"publicationDate":"2026-04-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147754902","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Programmable Morphing DNA Nanodevice Enables Triple Signal Amplification for Long-Term Early Tumor Metastasis Imaging. 可编程变形DNA纳米器件实现长期早期肿瘤转移成像的三重信号放大。

IF 16.6 1区化学

Angewandte Chemie International Edition Pub Date : 2026-04-29 DOI: 10.1002/anie.9917015

Huajie Pang,Run Yang,Hexv Niu,Zhe Hao,Fanghua Zhang,Hongyan Zhang,Jinzheng Liu,Huiping Zang,Ruizhong Zhang,Xiaohong Wang,Xiyan Li,Libing Zhang

{"title":"Programmable Morphing DNA Nanodevice Enables Triple Signal Amplification for Long-Term Early Tumor Metastasis Imaging.","authors":"Huajie Pang,Run Yang,Hexv Niu,Zhe Hao,Fanghua Zhang,Hongyan Zhang,Jinzheng Liu,Huiping Zang,Ruizhong Zhang,Xiaohong Wang,Xiyan Li,Libing Zhang","doi":"10.1002/anie.9917015","DOIUrl":"https://doi.org/10.1002/anie.9917015","url":null,"abstract":"Accurate early detection of tumor metastasis remains a formidable clinical challenge owing to the lack of imaging tools that can simultaneously respond sensitively to early metastatic signals and maintain enduring intracellular functionality. Here, we report a programmable morphing DNA nanodevice (PMDN) that integrates catalytic hairpin assembly (CHA) with a hybrid network amplification mechanism to achieve dual-stage intracellular assembly and ultrasensitive detection of metastatic biomarkers. The acidic lysosomal milieu induces i-motif-mediated conformational folding into a compact and nuclease-resistant structure. Following lysosomal escape, cytoplasmic miR-221 triggers a secondary-stage CHA cascade, driving large-scale crosslinking of DNA monomers into a stable nanonetwork. This dynamic bottom-up assembly ensures prolonged intracellular structural integrity of PMDN and concomitantly enables triple-stage signal amplification. Compared with conventional CHA systems, PMDN achieves more than a 200-fold improvement in detection sensitivity, exhibits remarkably persistent fluorescence in MDA-MB-231 cells, and maintains durable tumor localization in vivo for over 10 days. In a metastatic mouse model, PMDN enables early visualization of pulmonary micrometastases through miR-221-activated signal amplification. These results establish environment-adaptive morphing DNA architectures as a powerful platform for real-time monitoring of early metastasis and long-term molecular imaging in complex biological environments.","PeriodicalId":125,"journal":{"name":"Angewandte Chemie International Edition","volume":"2 1","pages":"e9917015"},"PeriodicalIF":16.6,"publicationDate":"2026-04-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147754888","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Programmable Chimeric Antigen Receptor T Cell Circuits With DNA Computing for Precision Tumor Therapy. 可编程嵌合抗原受体T细胞电路与DNA计算精确肿瘤治疗。

IF 16.6 1区化学

Angewandte Chemie International Edition Pub Date : 2026-04-29 DOI: 10.1002/anie.9420497

Miao Zhang,Quan Zhang,Xin Yu,Yuhui Yan,Yueting Yu,Guangna Liu,Fenglin Wang,Xia Chu,Jian-Hui Jiang

{"title":"Programmable Chimeric Antigen Receptor T Cell Circuits With DNA Computing for Precision Tumor Therapy.","authors":"Miao Zhang,Quan Zhang,Xin Yu,Yuhui Yan,Yueting Yu,Guangna Liu,Fenglin Wang,Xia Chu,Jian-Hui Jiang","doi":"10.1002/anie.9420497","DOIUrl":"https://doi.org/10.1002/anie.9420497","url":null,"abstract":"Chimeric antigen receptor (CAR) T cells, a promising cancer therapeutics, still face challenges in safety and efficacy due to the incapability to precisely regulate T cell activation. Here we develop a DNA-logic CAR (DL-CAR) system that enables programmable targeting and precise ablation of tumors with specific antigen combination patterns. The DL-CAR system is engineered using HaloTag as an extracellular domain for DNA conjugation, which allows controlling the assembly of tumor-targeting aptamers for universal and combinatorial antigen recognition via DNA logic computation. DL-CAR-T cells are shown to be capable of targeting tumor cells with different antigens and controlling the CAR circuit through AND, OR, and INHIBIT Boolean logic for specific T-cell activation and cytolysis. The DL-CAR system demonstrated high efficacy for tumor eradication in mouse models, with the AND-, OR-, and INHIBIT-gated computation affording enhanced selectivity for tumors with specific antigen combinations. DL-CAR may provide a new paradigm to develop programmable CAR-T circuits for precision cancer therapy.","PeriodicalId":125,"journal":{"name":"Angewandte Chemie International Edition","volume":"26 1","pages":"e9420497"},"PeriodicalIF":16.6,"publicationDate":"2026-04-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147754904","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Decoupling Hydrogen Evolution From Continuous Irradiation via CO2-Mediated Proton-Coupled Electron Storage. 通过co2介导的质子耦合电子存储解耦连续辐照下的氢演化。

IF 16.6 1区化学

Angewandte Chemie International Edition Pub Date : 2026-04-29 DOI: 10.1002/anie.4189062

Hua-Qing Yin,Zhi-Yi Lv,Min-Min Guo,Fu-Li Sun,Gui-Lin Zhuang,Jing Ren,Shuang Yao,Tong-Bu Lu,Zhi-Ming Zhang

{"title":"Decoupling Hydrogen Evolution From Continuous Irradiation via CO2-Mediated Proton-Coupled Electron Storage.","authors":"Hua-Qing Yin,Zhi-Yi Lv,Min-Min Guo,Fu-Li Sun,Gui-Lin Zhuang,Jing Ren,Shuang Yao,Tong-Bu Lu,Zhi-Ming Zhang","doi":"10.1002/anie.4189062","DOIUrl":"https://doi.org/10.1002/anie.4189062","url":null,"abstract":"The intermittent nature of solar energy and the safety concerns of high-pressure hydrogen storage/transportation pose critical challenges to the widespread adoption of solar-driven hydrogen production. To address these challenges, we explored a metal-organic framework/polymeric carbon nitride (PCN) heterostructure with atomically dispersed Cu sites (Cu@MOF/PCN-n, n = 1-5, representing the initial mass percent of Cu@MOF-303 as 1%-5%). The optimized Cu@MOF/PCN-3 enables solar energy storage and decouples H2 evolution from continuous irradiation through CO2-mediated proton-coupled electron storage. Under CO2 atmosphere, Cu@MOF/PCN-3 demonstrates exceptional photoelectron storage capabilities under illumination and achieves a remarkable H2 production rate of 2.88 mmol g-1 in the dark, 3.2-fold enhancement compared to Ar-controlled systems. Experimental and theoretical investigations demonstrate that CO2 serves as a bifunctional electron-proton mediator, stabilizing photoelectrons via reversible carboxylation while facilitating proton transfer through *COOH intermediates, thereby decoupling H2 evolution from continuous irradiation. The single Cu site plays a pivotal role in regulating electron extraction and proton coupling, effectively overcoming the thermodynamic competition between CO2 reduction and hydrogen evolution reaction (HER). This work establishes a new paradigm for CO2-mediated dark photocatalysis, offering a dual solution to overcome the critical challenges of solar intermittency and safe H2 storage.","PeriodicalId":125,"journal":{"name":"Angewandte Chemie International Edition","volume":"27 1","pages":"e4189062"},"PeriodicalIF":16.6,"publicationDate":"2026-04-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147754905","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

From [NHC─H]• to Persistent σ-Complex Radicals: Photoinduced Radical Chemistry of Imidazolium Salts. 从[NHC─H]•到持久的σ-络合自由基：咪唑盐的光诱导自由基化学。

IF 16.6 1区化学

Angewandte Chemie International Edition Pub Date : 2026-04-29 DOI: 10.1002/anie.5517752

Filipp M Kolomeychuk,Lars J C van der Zee,Simon Mathew,Bas de Bruin,J Chris Slootweg

{"title":"From [NHC─H]• to Persistent σ-Complex Radicals: Photoinduced Radical Chemistry of Imidazolium Salts.","authors":"Filipp M Kolomeychuk,Lars J C van der Zee,Simon Mathew,Bas de Bruin,J Chris Slootweg","doi":"10.1002/anie.5517752","DOIUrl":"https://doi.org/10.1002/anie.5517752","url":null,"abstract":"Imidazolium salts are ubiquitous precursors to N-heterocyclic carbenes (NHCs), yet their radical chemistry remains largely unexplored, and structurally well-defined imidazolium-derived radicals are rare. Here, we show that visible-light excitation of charge-transfer (CT) bands of electron donor-acceptor (EDA) complexes between imidazolium cations and a triarylamine donor induces a single-electron transfer. Variable-temperature EPR spectroscopy reveals that irradiation at 100 K affords neutral [NHC─H]• radicals, which undergo protonation upon warming to room temperature to give the persistent σ-complex cations [IDippH2]•+ and [IXylH2]•+. Analysis of hyperfine couplings, in combination with density functional theory (DFT) calculations, establishes a close electronic analogy between [NHC─H2]•+ and the classical cyclohexadienyl radical [C6H7]•, highlighting σ-π hyperconjugation as the dominant stabilization motif. These findings identify imidazolium-derived σ-complex radicals as a unique class of carbene-based open-shell species and showcase imidazolium cations as noninnocent, redox-active platforms for controlled radical generation under mild photochemical conditions.","PeriodicalId":125,"journal":{"name":"Angewandte Chemie International Edition","volume":"16 1","pages":"e5517752"},"PeriodicalIF":16.6,"publicationDate":"2026-04-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147754903","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Mechanically Robust Ultrahigh Molecular Weight Supramolecular Hydrogels Reinforced by Synergistic Chain Entanglement, Hydrogen Bonding, and Nanoparticle Incorporation. 机械坚固的超高分子量超分子水凝胶，通过协同链缠结、氢键和纳米颗粒掺入增强。

IF 16.6 1区化学

Angewandte Chemie International Edition Pub Date : 2026-04-29 DOI: 10.1002/anie.5675930

Yue Zhao,Steven P Armes,Zesheng An

引用次数: 0

Topological Engineering From Non-Emissive Chiral Metallomacrocycle to Interlocked Architecture for Strong Circularly Polarized Luminescence. 从非发射手性金属大环到强圆偏振发光的互锁结构拓扑工程。

IF 16.6 1区化学

Angewandte Chemie International Edition Pub Date : 2026-04-29 DOI: 10.1002/anie.2560002

Jing-Hao Wei,Lin-Xi Shi,Xu-Yang Ding,Bo-Wen Dai,Jin-Yun Wang,Feng-Rong Dai,Han Cheng,Zhong-Ning Chen

{"title":"Topological Engineering From Non-Emissive Chiral Metallomacrocycle to Interlocked Architecture for Strong Circularly Polarized Luminescence.","authors":"Jing-Hao Wei,Lin-Xi Shi,Xu-Yang Ding,Bo-Wen Dai,Jin-Yun Wang,Feng-Rong Dai,Han Cheng,Zhong-Ning Chen","doi":"10.1002/anie.2560002","DOIUrl":"https://doi.org/10.1002/anie.2560002","url":null,"abstract":"Interlocked architectures are crucial for stabilizing specific conformations to achieve superior performance. Herein, we proposes a vacant π-site recombination strategy to achieve significant luminescence enhancement through topological engineering from non-emissive chiral metallomacrocycles (R/S-Au4) to highly circularly polarized luminescence (CPL) catenanes (R/S-Au8). The dynamical structural transformation of metallomacrocycles (R/S-Au4) to catenanes (R/S-Au8) was monitored by 1H and 31P NMR spectroscopy. Excited state dynamics and theoretical studies revealed that the increase of heavy atom effect in catenanes (R/S-Au8) effectively increases spin-orbit coupling constant from 4.03 (R-Au4) to 48.22 cm-1 (R-Au8), facilitating the intersystem crossing between S1 and T1. While R/S-Au4 with flexible metallocyclic structures tend to rapidly relax the excited states through thermally vibrational processes, interlocked structures of R/S-Au8 lead to better rigidity, thus effectively suppressing non-radiative deactivation and facilitating radiative T1→S0 relaxation, thus achieving highly efficient CPL with ca. 39% quantum yield in solution. Solution-processed circularly polarized organic light-emitting diodes (CP-OLEDs) based on R/S-Au8 attain high-efficiency deep-red circularly polarized electroluminescence (CPEL) peaked at 685 nm, with external quantum efficiency (EQE) of 9.9% and electroluminescence asymmetric factor of ± 2.2 × 10-3. In any case, this upgrading approach from discrete macrocycles to interlocked architectures opens a new avenue for developing high-performance emitting materials and devices.","PeriodicalId":125,"journal":{"name":"Angewandte Chemie International Edition","volume":"72 1","pages":"e2560002"},"PeriodicalIF":16.6,"publicationDate":"2026-04-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147754918","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Bioinspired Molecular Engineering of IRE1-Gated DNAzymes for Self-Adaptive Bidirectional Modulation of ER Stress 内质网胁迫自适应双向调节ire1门控DNAzymes的生物启发分子工程

IF 16.6 1区化学

Angewandte Chemie International Edition Pub Date : 2026-04-28 DOI: 10.1002/anie.2970755

Chuangui Sheng, Jian Zhao, Nan Liu, Yuliang Zhao, Lele Li

{"title":"Bioinspired Molecular Engineering of IRE1-Gated DNAzymes for Self-Adaptive Bidirectional Modulation of ER Stress","authors":"Chuangui Sheng, Jian Zhao, Nan Liu, Yuliang Zhao, Lele Li","doi":"10.1002/anie.2970755","DOIUrl":"https://doi.org/10.1002/anie.2970755","url":null,"abstract":"Precise regulation of endoplasmic reticulum (ER) stress signaling in cancer remains a central challenge for nucleic acid–based therapeutics, largely due to their inability to discriminate ER-stressed malignant cells and non-stressed normal cells. Here we report an ER stress–responsive regulatory platform that couples the disease-associated endoribonuclease activity of inositol-requiring enzyme 1 (IRE1) to the conditional activation of DNA-based effectors. By rationally grafting an X-box binding protein 1 (XBP1)-mimetic stem–loop “gate” onto canonical DNAzymes (IR-Dz), we generate constructs that remain catalytically inert under basal IRE1 activity but are activated upon ER stress–induced IRE1 cleavage. The resulting IR-Dz mediates cell-selective c-MYC silencing in ER-stressed cancer cells, thereby attenuating ER stress while sparing normal counterparts. Redirecting IR-Dz to IRE1 mRNA achieves the opposite outcome—self-silencing of IRE1 and amplification of ER stress in tumor cells. This modular architecture can be adapted to other nucleic-acid modalities, such as antisense oligonucleotides. By establishing IRE1 as an endogenous molecular trigger for spatially and contextually precise activation of nucleic acid effectors, our study introduces a general strategy for programmable, condition-dependent gene regulation and dynamic modulation of ER stress signaling in cancer.","PeriodicalId":125,"journal":{"name":"Angewandte Chemie International Edition","volume":"2 1","pages":"e2970755"},"PeriodicalIF":16.6,"publicationDate":"2026-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147755243","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Multiple-Bonding and Lability: Study of an Anionic Vanadium Alumanyl 阴离子型钒铝基的多键性和稳定性研究

IF 16.6 1区化学

Angewandte Chemie International Edition Pub Date : 2026-04-28 DOI: 10.1002/anie.3250436

Pavel Zatsepin, Chaoqi Chen, Takumi Moriyama, Satoshi Muratsugu, Mizuki Tada, Ka Lok Chan, Zhenyang Lin, Makoto Yamashita

引用次数: 0