Angewandte Chemie International Edition最新文献

Outside Front Cover: Molecular Engineering of a Rigid Tetradentate Pt(II) Emitter for High‐Performance OLEDs Realizing the BT.2020 Blue Gamut 外封面：用于实现BT.2020蓝色域的高性能oled的刚性四齿Pt（II）发射器的分子工程

IF 16.6 1区化学

Angewandte Chemie International Edition Pub Date : 2025-10-04 DOI: 10.1002/anie.202521331

Kewei Xu, Chengyao Zhang, Liping Yang, Feng Zhan, Weiwei Lou, Yun Fang Yang, Yuanbin She, Guijie Li

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Electrochemical Late‐Stage Stitching of Tryptophan Peptides via N─S Bond Formation 通过N─S键形成的色氨酸肽的电化学后期拼接

IF 16.6 1区化学

Angewandte Chemie International Edition Pub Date : 2025-10-04 DOI: 10.1002/anie.202517101

Xinwei Hu, Zaimu Cao, Mu Chen, Chun‐Dong Huang, Shao‐Fei Ni, Shou‐Kun Zhang, Zhixiong Ruan

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Statistical Sampling‐Driven Design for Supported Bimetallic Nanocatalysts for CO2 Reduction 统计抽样驱动设计的支持双金属纳米催化剂的二氧化碳减少

IF 16.6 1区化学

Angewandte Chemie International Edition Pub Date : 2025-10-04 DOI: 10.1002/anie.202513744

Ziwei Wang, Jiawei Bai, Jieqiong Ding, Fei Wang, Xiaochun Liu, Xingchen Liu, Weixin Huang, Xiaodong Wen, Zhenhua Zhang

{"title":"Statistical Sampling‐Driven Design for Supported Bimetallic Nanocatalysts for CO2 Reduction","authors":"Ziwei Wang, Jiawei Bai, Jieqiong Ding, Fei Wang, Xiaochun Liu, Xingchen Liu, Weixin Huang, Xiaodong Wen, Zhenhua Zhang","doi":"10.1002/anie.202513744","DOIUrl":"https://doi.org/10.1002/anie.202513744","url":null,"abstract":"Tailoring supported bimetals to alloyed or phase‐separated structures is of vital importance while this process is blocked by the support interferences during universal impregnation processes. Conventional trial‐and‐error approaches rooted in chemical intuition often lack efficiency and generality. Here, we present a design strategy guided by the statistical sampling of comparative ease of alloy formation through the metadynamics‐based gas–solid nanoreactor approach, which enables the rational and systematic development of bimetallic nanocatalysts (NCs). Using metal oxide‐supported PdAu coupling with model CO2 reduction as a proof‐of‐concept system, the integrated theoretical and experimental results not only validated the reliability of simulation results but also successfully predicted and realized the alloy formation or phase separation of supported PdAu NCs. The generated PdAu alloys over CeO2 weaken the metallicity of supported Pd species and thus the catalytic hydrogenation property, but increase moderate basicity, contributing to activated CO2 hydrogenation to CO via a formate intermediate. However, the phase separation of Pd and Au over TiO2 support promotes formic acid production efficiency attributed to increasing weak basicity to accelerate CO2 activation during a bicarbonate pathway. These findings highlight statistical sampling as a general broadly applicable framework for the rational design of advanced bimetallic NCs.","PeriodicalId":125,"journal":{"name":"Angewandte Chemie International Edition","volume":"4 1","pages":""},"PeriodicalIF":16.6,"publicationDate":"2025-10-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145215908","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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Outside Front Cover: Multifunctional Electronic Textiles for the Simultaneous Detection and Uptake of Hydrogen Sulfide 外封面：用于同时检测和吸收硫化氢的多功能电子纺织品

IF 16.6 1区化学

Angewandte Chemie International Edition Pub Date : 2025-10-04 DOI: 10.1002/anie.202521330

Evan L. Cline, Juan L. Obeso, Ghada Al‐Kadamany, Aída Gutiérrez‐Alejandre, Peyton Kanaly, Hyuk‐Jun Noh, Emma Ambrogi, J. Gabriel Flores, Brandon Blount, Gregory W. Peterson, Giovanni Barcaro, Susanna Monti, Ilich A. Ibarra, Katherine A. Mirica

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The 23rd European Symposium on Organic Chemistry (ESOC‐2025) in Copenhagen 第23届欧洲有机化学研讨会（ESOC‐2025）在哥本哈根举行

IF 16.6 1区化学

Angewandte Chemie International Edition Pub Date : 2025-10-04 DOI: 10.1002/anie.202518918

Frederik Simonsen Bro, Christian Marcus Pedersen, Michael Pittelkow

{"title":"The 23rd European Symposium on Organic Chemistry (ESOC‐2025) in Copenhagen","authors":"Frederik Simonsen Bro, Christian Marcus Pedersen, Michael Pittelkow","doi":"10.1002/anie.202518918","DOIUrl":"https://doi.org/10.1002/anie.202518918","url":null,"abstract":"The 23rd in the series of “European Symposium on Organic Chemistry” (ESOC) was held at Tivoli Congress Center in Copenhagen from June 29th to July 3rd of 2025. ESOC was held for the first time in Cologne, Germany, in 1979, and has since been held approximately every other year. This year, Christian Marcus Pedersen and Michael Pittelkow from the Department of Chemistry at the University of Copenhagen hosted the event, and there were 619 registered participants from 49 countries. There were 13 plenary lectures, 13 invited lectures, and 21 “oral communications” that had been selected on the basis of applications. There were two poster sessions with a total of 350 posters. A total of six poster prizes were awarded, two awarded by the attendees via the app and four awarded by the poster prize committee. Among the total of 47 lectures, the “Patai‐Rappoport lecture award” was presented by Eric Jacobsen from Harvard University, “Dr. The Margaret Faul Women in Chemistry award” lectures given by Franziska Schoenebeck from Aachen University (Academia Award), and Dani Schultz from Merck (Industry Award). EuChemS awarded the “Award for research 2024” to Ilan Marek from Technion and the ‘Young investigator award 2024′ to Aurélien de la Torre from d'Orsay. The EuChemS Award for ‘Award for service 2024′ was awarded to Berit Olofsson from Stockholm University.","PeriodicalId":125,"journal":{"name":"Angewandte Chemie International Edition","volume":"26 1","pages":""},"PeriodicalIF":16.6,"publicationDate":"2025-10-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145215906","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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Aggregation‐Enhanced‐Emission Polymer Donor Improves the Efficiency of Organic Solar Cells by Suppressing Nonradiative Recombination 聚合-增强-发射聚合物供体通过抑制非辐射重组提高有机太阳能电池的效率

IF 16.6 1区化学

Angewandte Chemie International Edition Pub Date : 2025-10-04 DOI: 10.1002/anie.202516421

Lingzhi Guo, Lunbi Wu, Tao Jia, Huotian Zhang, Jiali Song, Xianqiang Xie, Min Hun Jee, Haisheng Ma, Sha Liu, Guanghao Lu, Han Young Woo, Zhen Wang, Feng Gao, Yanming Sun

{"title":"Aggregation‐Enhanced‐Emission Polymer Donor Improves the Efficiency of Organic Solar Cells by Suppressing Nonradiative Recombination","authors":"Lingzhi Guo, Lunbi Wu, Tao Jia, Huotian Zhang, Jiali Song, Xianqiang Xie, Min Hun Jee, Haisheng Ma, Sha Liu, Guanghao Lu, Han Young Woo, Zhen Wang, Feng Gao, Yanming Sun","doi":"10.1002/anie.202516421","DOIUrl":"https://doi.org/10.1002/anie.202516421","url":null,"abstract":"Nonradiative voltage loss (ΔVnr) is a critical factor that limits the efficiency of organic solar cells (OSCs). Introducing highly luminescent materials is a promising approach to reduce ΔVnr. The majority of prior works have focused on enhancing luminescence of low‐bandgap nonfullerene acceptors, whereas highly luminescent donors have received far less attention. Herein, we designed and synthesized a highly luminescent polymer donor with aggregation‐enhanced emission property, namely PiNTSO‐F, and incorporated it into PM6:BTP‐eC9‐based system. Interestingly, PiNTSO‐F was found to locate at the donor–acceptor interface, where it optimizes the interfacial morphology, energetic landscape, and charge dynamics of the active layer. Consequently, the nonradiative recombination rate in the ternary system is significantly reduced, while the interfacial charge generation efficiency is simultaneously improved to nearly unity, effectively minimizing ΔVnr of the device. As a result, the ternary devices achieve a low ΔVnr of 0.192 V and a high efficiency of 20.36%. This work demonstrates an effective strategy for suppressing ΔVnr through developing the highly luminescent polymer donors as a third component, providing mechanistic insights that enable high‐performance OSCs with minimized voltage loss.","PeriodicalId":125,"journal":{"name":"Angewandte Chemie International Edition","volume":"74 1","pages":""},"PeriodicalIF":16.6,"publicationDate":"2025-10-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145215907","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Visible‐Light‐Induced [2π+2σ] Cycloaddition Enabled by Cage‐Confined Photocatalysis for Precise Bicyclo[2.1.1]Hexane Construction 笼型光催化下的可见光诱导[2π+2σ]环加成对精确双环[2.1.1]己烷结构的影响

IF 16.6 1区化学

Angewandte Chemie International Edition Pub Date : 2025-10-04 DOI: 10.1002/anie.202517394

Yanke Hao, Jie Chen, Zhiwei Jiao, Cheng‐Yong Su

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Inside Back Cover: Toward Bimetallic Nanowire Arrays with Controlled Compositions Using Block Copolymer Films: the Interplay Between Metal Precursors 内页封底：利用嵌段共聚物薄膜控制组合物的双金属纳米线阵列：金属前体之间的相互作用

IF 16.6 1区化学

Angewandte Chemie International Edition Pub Date : 2025-10-04 DOI: 10.1002/anie.202521589

Ofer Burg, Carmel Cohen, Roy Shenhar

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Discovery of Antivirulence ClpP Inhibitors by Self‐Resistance Gene‐Guided Mining Coupled with Dual Functional Screening 自我抗性基因引导挖掘结合双功能筛选发现抗毒ClpP抑制剂

IF 16.6 1区化学

Angewandte Chemie International Edition Pub Date : 2025-10-04 DOI: 10.1002/anie.202514683

Yongchao Wang, Jinhuan Yin, Weiting Liao, Yanwei Gao, Yan Yao, Li Lu, Weixin Tao, Fan Zhang

{"title":"Discovery of Antivirulence ClpP Inhibitors by Self‐Resistance Gene‐Guided Mining Coupled with Dual Functional Screening","authors":"Yongchao Wang, Jinhuan Yin, Weiting Liao, Yanwei Gao, Yan Yao, Li Lu, Weixin Tao, Fan Zhang","doi":"10.1002/anie.202514683","DOIUrl":"https://doi.org/10.1002/anie.202514683","url":null,"abstract":"The global threat of MRSA demands innovative anti‐virulence strategies. Caseinolytic peptidase P (ClpP), a central virulence regulator in MRSA, represents an attractive yet underexploited target. Here, we developed a discovery platform integrating self‐resistance gene‐guided genome mining with dual functional screening, combining fluorometric‐based assay and counter‐screening against ADEP‐induced ClpP activation. This led to the discovery of streptoclipamides A–G, novel hybrid polyketide‐nonribosomal peptide ClpP inhibitors from str BGC, validated via heterologous expression and gene knockout. Structure–activity relationship studies enabled by engineered analogues identified key pharmacophores. Streptoclipamide A potently inhibits ClpP (IC50 = 480 nM) by engaging Thr72 via its C‐21 hydroxyl group, confirmed by biophysics and self‐resistance‐conferring T72P mutation. Streptoclipamide A suppressed MRSA virulence in vitro by reducing critical toxin production, including α‐hemolysin, and demonstrated protection in Galleria mellonella and murine pneumonia models. This work expands chemical diversity of ClpP‐targeting agents, and establishes a genome mining‐driven platform for discovering new therapeutics against antibiotic‐resistant pathogens.","PeriodicalId":125,"journal":{"name":"Angewandte Chemie International Edition","volume":"121 1","pages":""},"PeriodicalIF":16.6,"publicationDate":"2025-10-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145215914","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Electrochemical Assembly of a Defective Cu Catalyst for High Current CO2 Electrolysis to Methane in a Zero‐Gap Electrolyzer 零间隙电解槽中高电流CO2电解制甲烷用缺陷铜催化剂的电化学组装

IF 16.6 1区化学

Angewandte Chemie International Edition Pub Date : 2025-10-04 DOI: 10.1002/anie.202515396

Qin Yang, Xiu Wang, Yuqi Yang, Ziyu Mi, Lei Wang, Yu‐Jhih Shen, Kang‐Shun Peng, Mingsheng Zhang, Tanmay Ghosh, Ruoou Yang, Linrong Huang, Jiguang Zhang, Zainul Aabdin, Wan Ru Leow, Sung‐Fu Hung, Ziyun Wang, Yanwei Lum

{"title":"Electrochemical Assembly of a Defective Cu Catalyst for High Current CO2 Electrolysis to Methane in a Zero‐Gap Electrolyzer","authors":"Qin Yang, Xiu Wang, Yuqi Yang, Ziyu Mi, Lei Wang, Yu‐Jhih Shen, Kang‐Shun Peng, Mingsheng Zhang, Tanmay Ghosh, Ruoou Yang, Linrong Huang, Jiguang Zhang, Zainul Aabdin, Wan Ru Leow, Sung‐Fu Hung, Ziyun Wang, Yanwei Lum","doi":"10.1002/anie.202515396","DOIUrl":"https://doi.org/10.1002/anie.202515396","url":null,"abstract":"CO2 electrolysis to methane offers a promising route toward enabling long‐term storage of renewable energy. However, electrolysis in zero‐gap membrane electrode assembly (MEA) systems using conventional Cu‐based electrocatalysts is typically limited by relatively low methane productivity and Faradaic efficiency (FE). Here, we conceived an electrochemical assembly strategy that forms a Cu(111)‐dominant catalyst with vacancy defects. In an MEA system at a total current of 1.5 A, the catalyst (Def‐Cu6) achieved a record methane FE of 71.46% and production rate of 0.28 µmol s−1 cm−2, with relatively stable operation over 10 h. Density functional theory calculations reveal the crucial role of vacancy defects in a Cu(111) surface, which favors the hydrogenation of CO* and promotes methane formation over the competing CO* coupling pathway that leads to multicarbon products. Our findings demonstrate how vacancy defects can be tuned to control catalytic outcomes.","PeriodicalId":125,"journal":{"name":"Angewandte Chemie International Edition","volume":"97 1","pages":""},"PeriodicalIF":16.6,"publicationDate":"2025-10-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145215540","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0