Angewandte Chemie International Edition最新文献_第2页

Inside Front Cover: Chemical Process Development in the Pharmaceutical Industry in Europe: Insights and Perspectives from Industry Scientists

IF 16.6 1区化学

Angewandte Chemie International Edition Pub Date : 2025-03-28 DOI: 10.1002/anie.202505858

Joachim Krueger, André P. Dieskau, Jorma Hassfeld, Joerg Gries, Oliver Block, Hilmar Weinmann, Daniel Kaufmann, Stefan Hildbrand, Volker Kraft, Robert Moeckel, Juan R. Dehli, Ulrich Scholz, Carl Friedrich Nising

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Outside Front Cover: Roadmap to Catalytic Abatement of Gas Phase Per‐ and Polyfluoroalkyl Substances (PFAS)

IF 16.6 1区化学

Angewandte Chemie International Edition Pub Date : 2025-03-28 DOI: 10.1002/anie.202506110

Patrick Lott, Florian Maurer, Arik Beck

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Functional Ambidexterity of an Ancient Nucleic Acid‐Binding Domain

IF 16.6 1区化学

Angewandte Chemie International Edition Pub Date : 2025-03-28 DOI: 10.1002/anie.202505188

Liam Longo, Orit Weil-Ktorza, Segev Naveh-Tassa, Yael Fridmann-Sirkis, Dragana Despotović, Kesava Phaneendra Cherukuri, Tatsuya Corlett, Yaakov Levy, Norman Metanis

{"title":"Functional Ambidexterity of an Ancient Nucleic Acid‐Binding Domain","authors":"Liam Longo, Orit Weil-Ktorza, Segev Naveh-Tassa, Yael Fridmann-Sirkis, Dragana Despotović, Kesava Phaneendra Cherukuri, Tatsuya Corlett, Yaakov Levy, Norman Metanis","doi":"10.1002/anie.202505188","DOIUrl":"https://doi.org/10.1002/anie.202505188","url":null,"abstract":"The helix‐hairpin‐helix (HhH) motif is an ancient and ubiquitous nucleic acid‐binding element that has emerged as a model system for studying the evolution of dsDNA‐binding domains from simple peptides that phase separate with RNA. We analyzed the entire putative evolutionary trajectory of the HhH motif – from a flexible peptide to a folded domain – for functional robustness to total chiral inversion. Against expectations, functional ‘ambidexterity’ was observed for both the phase separation of HhH peptides with RNA and binding of the duplicated (HhH)2‐Fold to dsDNA. Moreover, dissociation kinetics, mutational analysis, and molecular dynamics simulations revealed overlap between the binding modes adopted by the natural and mirror‐image proteins to natural dsDNA. The similarity of several dissociation phases upon chiral inversion may reflect the history of (HhH)2‐Fold binding, with the ultimate emergence of a high‐affinity binding mode, supported by a bridging metal ion, depopulating but not displacing more primitive (potentially ambidextrous) modes. These data underscore the surprising functional robustness of the HhH protein family and suggest that the veil between worlds with alternative chiral preferences may not be as impenetrable as is often assumed.","PeriodicalId":125,"journal":{"name":"Angewandte Chemie International Edition","volume":"50 1","pages":""},"PeriodicalIF":16.6,"publicationDate":"2025-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143723375","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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Carbon‐Extraction‐Triggered Phase Engineering of Rhodium Nanomaterials for Efficient Electrocatalytic Nitrate Reduction Reaction

IF 16.6 1区化学

Angewandte Chemie International Edition Pub Date : 2025-03-28 DOI: 10.1002/anie.202500985

Long Zheng, Yan Zhang, Weiwei Chen, Xiangou Xu, Ruiqi Zhang, Xiao Ren, Xiaozhi Liu, Wenbin Wang, Junlei Qi, Gang Wang, Chen Ma, Lei Xu, Peng Han, Qiyuan He, Ding Ma, Jinlan Wang, Chongyi Ling, Dong Su, Minhua Shao, Ye Chen

{"title":"Carbon‐Extraction‐Triggered Phase Engineering of Rhodium Nanomaterials for Efficient Electrocatalytic Nitrate Reduction Reaction","authors":"Long Zheng, Yan Zhang, Weiwei Chen, Xiangou Xu, Ruiqi Zhang, Xiao Ren, Xiaozhi Liu, Wenbin Wang, Junlei Qi, Gang Wang, Chen Ma, Lei Xu, Peng Han, Qiyuan He, Ding Ma, Jinlan Wang, Chongyi Ling, Dong Su, Minhua Shao, Ye Chen","doi":"10.1002/anie.202500985","DOIUrl":"https://doi.org/10.1002/anie.202500985","url":null,"abstract":"Phase engineering plays a crucial role in tuning the physicochemical properties of noble metal nanomaterials. However, synthesis of high‐purity unconventional‐phase noble metal nanomaterials remains highly challenging via current wet‐chemical methods. Herein, we develop a unique synthetic methodology to prepare freestanding unconventional hexagonal‐close packed (2H) Rh nanoplates (NPLs) via a rationally designed two‐step strategy. By extracting C from pre‐synthesized rhodium carbide of different sizes and morphology, phase‐controlled synthesis of Rh nanomaterials can be achieved. Impressively, the obtained parallelogram 2H Rh NPLs have high phase purity, well‐defined 2H (0001)h and (10[[EQUATION]]0)h facets, and good thermostability (stable up to 300 °C). In the proof‐of‐concept electrocatalytic nitrate reduction reaction (NO3RR), the 2H Rh NPLs achieve higher ammonia (NH3) Faradaic efficiency (91.9%) and NH3 yield rate (156.97 mg h‐1 mgcat‐1) with lower overpotentials compared to the conventional face‐centered cubic Rh nanocubes with (100)f facets. Density functional theory calculations reveal that the unconventional (0001)h surface has energetically favored NO3RR pathway and stronger H*absorption ability compared to the (100)f surface, which may lead to the higher activity and selectivity of NH3 production on 2H Rh NPLs. This work opens new avenues to the rational synthesis of unconventional‐phase metal nanomaterials and provides important guidelines to design high‐performance electrocatalysts.","PeriodicalId":125,"journal":{"name":"Angewandte Chemie International Edition","volume":"25 1","pages":""},"PeriodicalIF":16.6,"publicationDate":"2025-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143723314","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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Dual-responsive phosphorus-based fluorescent sensors: synthesis and selective metal sensing of pyrazolyl phosphine oxides

IF 16.6 1区化学

Angewandte Chemie International Edition Pub Date : 2025-03-28 DOI: 10.1002/anie.202501421

Ethan D E Calder, Isobel R J Hawes, Andrew R. Jupp

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Stabilizing Surface Lattice On- (0

IF 16.6 1区化学

Angewandte Chemie International Edition Pub Date : 2025-03-28 DOI: 10.1002/anie.202503100

Wenguang Zhao, Mingyang Li, Zijian Li, Hengyu Ren, Xiaohu Wang, Xingxing Yin, Wangyang Ding, Guojie Chen, Shiming Chen, Haocong Yi, Shunning Li, Jun Wang, Dong Zhou, Lin Zhou, Hai Lin, Bin Fei, Feng Pan, Qinghe Zhao

{"title":"Stabilizing Surface Lattice On- (0","authors":"Wenguang Zhao, Mingyang Li, Zijian Li, Hengyu Ren, Xiaohu Wang, Xingxing Yin, Wangyang Ding, Guojie Chen, Shiming Chen, Haocong Yi, Shunning Li, Jun Wang, Dong Zhou, Lin Zhou, Hai Lin, Bin Fei, Feng Pan, Qinghe Zhao","doi":"10.1002/anie.202503100","DOIUrl":"https://doi.org/10.1002/anie.202503100","url":null,"abstract":"The instability of surface lattice On- (0<n<2) in the charged LiCoO₂ (LCO) limits its long-term cycling stability beyond 4.55 V vs. Li/Li⁺. Herein, the spinel and rock-salt (RS) phases are constructed on the LCO surface to stabilize lattice On-, namely S-LCO and R-LCO, respectively. Upon long-term cycling at 4.6 V, the loss of lattice On- leads to a progressive deterioration of surface spinel phase, which ultimately transfers to a strong Li+-blocking phase. In contrast, for R-LCO, the surface lattice On- in the RS phase retains stable in long-term cycles. Theoretical calculations reveal that the migration barriers of lattice On- are significantly higher in the RS phase than that in the spinel phase. Due to the stabilized surface lattice On-, the R-LCO||Li cell shows a impressive capacity retention of 78.6% in 1000 cycles at 4.6 V (current of 1 C), and superior floating charge durability at 45℃. This study highlights the importance of surface structure tailoring in developing the advanced LCO cathodes.","PeriodicalId":125,"journal":{"name":"Angewandte Chemie International Edition","volume":"72 1","pages":""},"PeriodicalIF":16.6,"publicationDate":"2025-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143723892","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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Outside Back Cover: Straightforward Formation of Borirenes from Boroles and Dialkynes

IF 16.6 1区化学

Angewandte Chemie International Edition Pub Date : 2025-03-28 DOI: 10.1002/anie.202506308

Pedro H. R. Oliveira, Marieli O. Rodrigues, Caren D. G. da Silva, Josina Bohlen, Merle Arrowsmith, Arumugam Jayaraman, Lukas Lubczyk, Felipe Fantuzzi, Eufrânio N. da Silva Júnior, Holger Braunschweig

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Controlled Catalysis Delivering High Molecular Weight Polyesters as Recyclable Alternatives to Polystyrenes

IF 16.6 1区化学

Angewandte Chemie International Edition Pub Date : 2025-03-28 DOI: 10.1002/anie.202505070

Nora Janssen, Kam C. Poon, Alexander C. Craze, Chang Gao, Charlotte K. Williams

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Cyclo-P5− Revisited: The Surprisingly Stable Uncoordinated Pentaphospholide Anion

IF 16.6 1区化学

Angewandte Chemie International Edition Pub Date : 2025-03-28 DOI: 10.1002/anie.202505853

Moritz Ernst, Andrey Petrov, Mirjam Schröder, Björn Corzilius, Christian Müller

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3‐Oxabicyclo[3.1.1]heptane as an Isostere for meta‐Benzene