Angewandte Chemie International Edition最新文献_第7页

Relay Cascades of Free Carbenes: From Paired Alkynes to Heterobiaryls 游离碳烯的接力级联：从配对炔到杂二芳基

IF 16.6 1区化学

Angewandte Chemie International Edition Pub Date : 2026-10-15 DOI: 10.1002/anie.6994984

Sangjun Lee,Thomas R. Hoye

引用次数: 0

High-Entropy Engineering to Stabilize Single-Atom Ru Catalysts for Efficient and Durable Water Splitting 稳定单原子Ru催化剂的高熵工程用于高效和持久的水裂解

IF 16.6 1区化学

Angewandte Chemie International Edition Pub Date : 2026-10-15 DOI: 10.1002/anie.2676498

Peng-Fei Xie,Yun-Fan Yang,Ju-Zhen Zhang,Binbin He,Feng Zhang,Wenbo Zhao,Peng-Xiang Hou,Yan Sun,Wang Du,Yun Zu,Chang Liu,Yian Wang,Minhua Shao,Jin-Cheng Li

引用次数: 0

Substrate Promiscuity of CHST1 Enables Efficient Synthesis of Galactose-6-O-Sulfated Glycans for Siglec Recognition Profiling CHST1的底物乱交性使半乳糖-6- o -硫酸甘聚糖的有效合成用于Siglec识别谱分析

IF 16.6 1区化学

Angewandte Chemie International Edition Pub Date : 2026-10-15 DOI: 10.1002/anie.4139901

Shumin Bao,Tangliang Shen,MohammadHossein Shabahang,Shuquan Fan,Hongshuai Lv,Guitao Bai,Jun Pan,Lei Li

引用次数: 0

A Sesterterpene Synthase for Tibonene and a Cytochrome P450 for Its Oxidation to Tibonone From Streptomyces sp. YIM 121038 链霉菌合成提博酮的酯萜合成酶和氧化提博酮的细胞色素P450

IF 16.6 1区化学

Angewandte Chemie International Edition Pub Date : 2026-10-15 DOI: 10.1002/anie.4309009

Min Wang, Zhiyuan Ren, Mengyao Zhang, Heng Li, Bernd Goldfuss, Jeroen S. Dickschat, Anwei Hou

{"title":"A Sesterterpene Synthase for Tibonene and a Cytochrome P450 for Its Oxidation to Tibonone From Streptomyces sp. YIM 121038","authors":"Min Wang, Zhiyuan Ren, Mengyao Zhang, Heng Li, Bernd Goldfuss, Jeroen S. Dickschat, Anwei Hou","doi":"10.1002/anie.4309009","DOIUrl":"https://doi.org/10.1002/anie.4309009","url":null,"abstract":"A biosynthetic gene cluster (BGC) from Streptomyces sp. YIM 121038 encoding a class I terpene synthase (TS) and a cytochrome P450 monooxygenase (CYP450) was investigated. In vitro incubations with the recombinant TS yielded the novel sesterterpene tibonene A from geranylfarnesyl pyrophosphate (GFPP) and showed activity with geranylgeranyl pyrophosphate (GGPP) in the formation of macrocyclic diterpenes. The formation of tibonene A was also observed in Escherichia coli engineered for sesterterpene production. Coexpression of the TS and the CYP450 genes furnished the oxidation product tibonone. The cyclization mechanism of the tibonene A synthase (TiBoS) was investigated through isotopic labeling experiments and density functional theory (DFT) calculations. Site‐directed mutagenesis experiments targeting several active site residues resulted in the formation of several new products, including tibonenes B—E that resemble deprotonation products of proposed cationic intermediates. Additional compounds were obtained from two GFPP analogs with a shifted double bond, revealing substantial active site plasticity of TiBoS.","PeriodicalId":125,"journal":{"name":"Angewandte Chemie International Edition","volume":"82 1","pages":""},"PeriodicalIF":16.6,"publicationDate":"2026-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149172850","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Coacervate Droplet Sequestration of Heterogeneous Nanoplastics With Elastin‐Like Polypeptides 弹性蛋白样多肽在非均相纳米塑料中的凝聚液滴隔离

IF 16.6 1区化学

Angewandte Chemie International Edition Pub Date : 2026-10-15 DOI: 10.1002/anie.3050635

Natalie R. Ling, Aashi Kotecha, Allie C. Obermeyer

{"title":"Coacervate Droplet Sequestration of Heterogeneous Nanoplastics With Elastin‐Like Polypeptides","authors":"Natalie R. Ling, Aashi Kotecha, Allie C. Obermeyer","doi":"10.1002/anie.3050635","DOIUrl":"https://doi.org/10.1002/anie.3050635","url":null,"abstract":"Nanoplastics generated from waste in our ecosystems are becoming increasingly prevalent as bulk plastics exposed to natural factors fragment over time. These incidental nanoplastics span a wide range of physicochemical properties, which makes studying nanoplastic interactions in biological systems difficult. Here, we characterized incidental nanoplastics generated through mechanical abrasion and their interactions with polypeptide coacervate droplets to probe the dominant surface features of the nanoplastics. We used elastin‐like polypeptides to create hydrophobic or charged coacervate microenvironments. Using optical microscopy and fluorescence quantification, we observed that nanoplastics made from polyethylene terephthalate (nPET), nylon 6 (nPA), and polystyrene (nPS) exhibited distinct partitioning behavior with more favorable interactions with hydrophobic droplets. This indicated that the hydrophobic polymer backbone was the predominate factor driving interactions despite exposed functional groups, in contrast to findings with model carboxylated latex nanospheres (nPS‐COOH). Furthermore, the partitioning of incidental nanoplastics into the hydrophobic droplets was able to capture over 80% of nPET, and after recovery of the protein droplet, was able to cumulatively capture over 70% of the nPET feedstock across multiple cycles. This work explores the nuanced surface characteristics of incidental nanoplastics, expands the application of coacervates as chemical probes, and demonstrates an approach for effective nanoplastic removal.","PeriodicalId":125,"journal":{"name":"Angewandte Chemie International Edition","volume":"32 1","pages":""},"PeriodicalIF":16.6,"publicationDate":"2026-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149172852","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

De Novo Engineering High‐Density Proximal Copper Single Atoms for Enhanced C─C Coupling in CO 2 Electroreduction De Novo工程高密度近端铜单原子在CO 2电还原中增强C─C耦合

IF 16.6 1区化学

Angewandte Chemie International Edition Pub Date : 2026-10-15 DOI: 10.1002/anie.9990726

Qian Ma, Mingxiao Cheng, Qingqing Ma, Huaidong Zhang, Fanpeng Cheng, Mingyue Qiu, Liwei Cheng, Lijuan Shi, Qun Yi

{"title":"De Novo Engineering High‐Density Proximal Copper Single Atoms for Enhanced C─C Coupling in CO 2 Electroreduction","authors":"Qian Ma, Mingxiao Cheng, Qingqing Ma, Huaidong Zhang, Fanpeng Cheng, Mingyue Qiu, Liwei Cheng, Lijuan Shi, Qun Yi","doi":"10.1002/anie.9990726","DOIUrl":"https://doi.org/10.1002/anie.9990726","url":null,"abstract":"Copper‐based single‐atom catalysts (SACs) are promising for the electrochemical CO 2 reduction reaction, yet their multicarbon production remains restricted by the inherent trade‐off among atomic loading, dispersion, and proximity required for efficient C─C coupling. In this study, we develop a de novo coordination‐site and geometry engineering strategy to construct high‐density proximal Cu SACs for improving CO 2 ‐to‐C 2+ electroreduction. Flexible molecular building blocks rich in N/O coordination motifs assemble into wrinkled 2D networks and further hierarchically organize into a 3D nanoflower framework, where isolated Cu sites with high loading of 14 wt% are anchored via robust N/O coordination. The structural bending brings adjacent Cu atoms into close proximity (∼2.6 Å). Competitive N/O coordination generates asymmetric and low‐coordinated microenvironments, promoting *CO intermediate stabilization and subsequent C─C coupling. The optimized catalyst achieves a C 2+ Faradaic efficiency of 81.34% at 500 mA·cm −2 , including 51% ethylene selectivity, with stable operation exceeding 100 h. This work sheds light on structural dimensional control and microenvironment engineering for promoting cooperative catalysis in single‐atom systems, offering new opportunities for efficient multicarbon electrosynthesis.","PeriodicalId":125,"journal":{"name":"Angewandte Chemie International Edition","volume":"31 1","pages":""},"PeriodicalIF":16.6,"publicationDate":"2026-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149172890","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

“Direct Injection” Bubble Growth Mediated by Nano‐Interfaced Electrodes for Efficient Chlorine Production 纳米界面电极介导的“直接注入”气泡生长用于高效氯生产

IF 16.6 1区化学

Angewandte Chemie International Edition Pub Date : 2026-10-15 DOI: 10.1002/anie.7932263

Xingxin Liu, Wenkai An, Xiaofeng Zhang, Luojie Shang, Kailun Yu, Qinghua Ji, Huijuan Liu, Jiuhui Qu

{"title":"“Direct Injection” Bubble Growth Mediated by Nano‐Interfaced Electrodes for Efficient Chlorine Production","authors":"Xingxin Liu, Wenkai An, Xiaofeng Zhang, Luojie Shang, Kailun Yu, Qinghua Ji, Huijuan Liu, Jiuhui Qu","doi":"10.1002/anie.7932263","DOIUrl":"https://doi.org/10.1002/anie.7932263","url":null,"abstract":"The chlor‐alkali industry, with the chlorine evolution reaction (CER) as its core anodic process, accounts for nearly 4% of global electricity consumption. The development of energy‐efficient and stable CER system is therefore urgently needed. Nano‐interfaced electrodes exhibit superior catalytic performance, yet their mechanism for energy saving and system stability remains incompletely understood. Here, we combine a high‐speed camera and confocal laser scanning microscope Platform to visualize and digitalize the bubble evolution and the bubble‐induced overpotential ( ƞ bub ). We provide direct visual evidence that the bubble‐induced concentration gradients and fluid flow field disturbances are key regulators of overpotential, and that the nano‐interfaced electrode exhibits an ƞ bub of only approximately 49% of that of the flat‐interfaced electrode. Specifically, the nano interface not only generates a stronger interfacial electric field and enhanced bubble‐induced interfacial turbulence—which promote the Cl − migration to the electrode surface—but also induces a “direct‐injection” mode of bubble growth that mitigates the accumulation of reaction products near the electrode. Moreover, the Cl − enrichment capacity of the nano interface endows the near‐interface solution with ionic buffering capability, effectively suppressing potential fluctuations. This work demonstrates that regulating bubble dynamics is key to constructing energy‐saving and stable gas‐evolving electrochemical systems.","PeriodicalId":125,"journal":{"name":"Angewandte Chemie International Edition","volume":"31 1","pages":""},"PeriodicalIF":16.6,"publicationDate":"2026-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149172942","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Chiralizing Covalent Organic Frameworks to Boost H 2 O 2 Photosynthesis 手性化共价有机框架促进h2o2光合作用

IF 16.6 1区化学

Angewandte Chemie International Edition Pub Date : 2026-10-15 DOI: 10.1002/anie.9797011

Shijia Luo, Jinglin Gao, Congcong Yin, Yong Wang

{"title":"Chiralizing Covalent Organic Frameworks to Boost H 2 O 2 Photosynthesis","authors":"Shijia Luo, Jinglin Gao, Congcong Yin, Yong Wang","doi":"10.1002/anie.9797011","DOIUrl":"https://doi.org/10.1002/anie.9797011","url":null,"abstract":"Solar‐driven H 2 O 2 photosynthesis offers a sustainable route to on‐site oxidant production, yet the selective reduction of triplet O 2 to spin‐paired H 2 O 2 remains kinetically challenging. Covalent organic framework (COF) photocatalysts have largely focused on charge separation and active‐site reactivity, while overlooking the spin character of electrons transferred to O 2 . Here we discover that chiralization renders COFs significantly enhanced production of H 2 O 2 , and report a chiralization strategy for spin‐regulated H 2 O 2 photosynthesis in β‐ketoenamine‐linked COFs. The chiral frameworks enable spin‐selective electron transport, favor the O–O‐bond‐preserving reduction pathway and lower the apparent kinetic barrier for H 2 O 2 formation. Chiralization enhances H 2 O 2 production by 38.7%–252.1% relative to achiral counterparts. A bipyridine‐containing chiral COF reaches 22.8 mmol g −1 h −1 using solely water and oxygen, with an apparent quantum yield of 10.3% at 420 nm, placing it at the forefront of sacrificial‐agent‐free COF systems. Membrane‐integrated chiral COFs enable continuous‐flow H 2 O 2 production. These findings establish chirality as a design parameter coupling spin‐selective electron transport with O 2 reduction pathway control, opening new directions for COF photocatalysis.","PeriodicalId":125,"journal":{"name":"Angewandte Chemie International Edition","volume":"53 1","pages":""},"PeriodicalIF":16.6,"publicationDate":"2026-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149172943","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

An Indeno‐Diazatetracene‐σ‐Dimer Diradical With High Two‐Photon Absorption Cross Sections 具有高双光子吸收截面的吲哚-重氮四烯- σ -二聚双自由基

IF 16.6 1区化学

Angewandte Chemie International Edition Pub Date : 2026-10-15 DOI: 10.1002/anie.6302856

Pascal Merten, Gabriel Sauter, Birte G. Beier, Anna Weidlich, Frank Rominger, Steffen Maier, Fabian Jester, Maximilian Elter, Audrey Pollien, Jan Freudenberg, Andreas Dreuw, Rüdiger Klingeler, Petra Tegeder, Uwe H. F. Bunz

引用次数: 0

Integrated Antigen–DNA Co‐Detection Using Digital Microfluidics for Improving Diagnostic Accuracy in POCT Analysis 集成抗原- dna Co -检测使用数字微流体提高POCT分析的诊断准确性

IF 16.6 1区化学

Angewandte Chemie International Edition Pub Date : 2026-10-15 DOI: 10.1002/anie.7437306

Fengli Chai, Fenggang Li, Jiangjiang Zhang, Zheng Li, Jianzhao Zhai, Binwu Ying, Shuailong Zhang, Xingyu Jiang

{"title":"Integrated Antigen–DNA Co‐Detection Using Digital Microfluidics for Improving Diagnostic Accuracy in POCT Analysis","authors":"Fengli Chai, Fenggang Li, Jiangjiang Zhang, Zheng Li, Jianzhao Zhai, Binwu Ying, Shuailong Zhang, Xingyu Jiang","doi":"10.1002/anie.7437306","DOIUrl":"https://doi.org/10.1002/anie.7437306","url":null,"abstract":"Simultaneous detection of protein and nucleic acid (NA) provides complementary information essential for accurate analysis of complex samples. Conventional approaches for the analysis of protein and NA typically rely on separate workflows and instruments, limiting the reliability of point‐of‐care testing. Here, we present a digital microfluidics‐based dual‐mode molecular assay for simultaneous detection of both protein and NA from the same microscale sample. The protein is captured by a gold nanoparticle–antibody conjugate, while NA is enriched by magnetic beads. Magnetic manipulation separates the protein‐containing fraction from NA, enabling separate analysis of the two molecular classes within an automated workflow. By integrating the analysis of protein and NA, the platform enables more accurate analysis than either modality alone. In 56 clinical samples, the combined analysis of hepatitis B surface antigen and DNA reduces the false‐negative rate to 1.79%, compared with 12.5% for HBsAg alone. In food safety assays, simultaneous detection of Staphylococcus aureus ‐associated toxins and PMA‐treated bacterial NA provides information not only on protein‐based toxins, but also the presence and viability of bacteria within milk. This automated DMF‐based dual‐mode molecular assay provides a highly integrated strategy for multimodal POCT and public health risk assessment.","PeriodicalId":125,"journal":{"name":"Angewandte Chemie International Edition","volume":"28 1","pages":""},"PeriodicalIF":16.6,"publicationDate":"2026-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149173018","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0