Angewandte Chemie International Edition最新文献

{"title":"Outside Back Cover: A Programmable and Printable Microbial Bioelectronic Sensor for Real-Time and Targeted Pollutant Monitoring in Water (Angew. Chem. Int. Ed. 43/2026)","authors":"Xing-Yu Wang,&nbsp;Yi-Xuan Wang,&nbsp;Jun Ding,&nbsp;Xiao-Li Liu,&nbsp;Meng-Jie Luo,&nbsp;Meng Liu,&nbsp;Dong-Feng Liu,&nbsp;Zhi-Xiang She,&nbsp;Yang Mu","doi":"10.1002/anie.2026-m2809065900","DOIUrl":"10.1002/anie.2026-m2809065900","url":null,"abstract":"<p>In the Research Article e1144662, Yi-Xuan Wang, Zhi-Xiang She, Yang Mu, and co-workers demonstrate a programmable microbial bioelectronic sensor for real-time pollutant monitoring in water. Engineered Shewanella oneidensis couples target recognition to extracellular electron transfer, converting pollutant signals into electrical outputs. Encapsulation within a printable hydrogel and integration into a biomimetic fractal bioelectrode accelerate mass transport, enabling rapid, selective sensing with wireless readout.\u0000\u0000 <figure>\u0000 <div><picture>\u0000 <source></source></picture><p></p>\u0000 </div>\u0000 </figure></p>","PeriodicalId":125,"journal":{"name":"Angewandte Chemie International Edition","volume":"65 43","pages":""},"PeriodicalIF":17.6,"publicationDate":"2026-10-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/anie.2026-m2809065900","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149086078","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Inside Front Cover: Enthalpy-Entropy Molecular Design of Gel Polymer Electrolytes for Regulating Solvation Chemistry in Lithium–Sulfur Batteries (Angew. Chem. Int. Ed. 43/2026)","authors":"Zirui Guo,&nbsp;Zihui Song,&nbsp;Runyue Mao,&nbsp;Naiwen Hu,&nbsp;Chang Su,&nbsp;Shuo Zhuo,&nbsp;Xigao Jian,&nbsp;Fangyuan Hu","doi":"10.1002/anie.2026-m2509035600","DOIUrl":"https://doi.org/10.1002/anie.2026-m2509035600","url":null,"abstract":"<p>In the Research Article e7695165, Fangyuan Hu and co-workers establish an enthalpy–entropy molecular design strategy for gel polymer electrolytes in lithium–sulfur batteries. By balancing local coordination enthalpy and configurational entropy, the electrolyte regulates Li⁺ and polysulfide solvation, lowers desolvation barriers, suppresses long-range polysulfide migration, and promotes uniform Li₂S nucleation, enabling stable cycling and high-energy-density pouch-cell performance.\u0000\u0000 <figure>\u0000 <div><picture>\u0000 <source></source></picture><p></p>\u0000 </div>\u0000 </figure></p>","PeriodicalId":125,"journal":{"name":"Angewandte Chemie International Edition","volume":"65 43","pages":""},"PeriodicalIF":17.6,"publicationDate":"2026-10-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/anie.2026-m2509035600","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149214654","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ultra‐Low Thermal Conductivity in Mixed Anionic CuTe 2 Cl: Strong Antibonding States and Lone Pair‐Induced Te Ring Puckering","authors":"Indrajit Haldar, Sayan Paul, Animesh Bhui, Anustoop Das, Subarna Das, Diptikanta Swain, Swapan K. Pati, Kanishka Biswas","doi":"10.1002/anie.2538518","DOIUrl":"https://doi.org/10.1002/anie.2538518","url":null,"abstract":"Metal chalcohalides, an emerging class of mixed‐anion compounds, have recently garnered increasing interest as they unite the exceptional stability of metal chalcogenides with the versatile electronic tunability of metal halides. Here, we synthesize single‐ and polycrystalline CuTe <jats:sub>2</jats:sub> Cl, a two‐dimensional layered metal chalcohalide, which exhibits intrinsically ultralow lattice thermal conductivity ( <jats:italic>κ</jats:italic> <jats:sub>lat</jats:sub> ) of ∼0.54–0.24 W m <jats:sup>−1</jats:sup> K <jats:sup>−1</jats:sup> between 300 and 600 K along the layered growth direction. Strong <jats:italic>p‐d*</jats:italic> antibonding states arising from Cu 3 <jats:italic>d</jats:italic> ‐Te 5 <jats:italic>p</jats:italic> and Cu 3 <jats:italic>d</jats:italic> ‐Cl 3 <jats:italic>p</jats:italic> interactions in the valence band just below the Fermi level weaken the Cu‐Te and Cu‐Cl bonds to render the lattice elastically soft. Moreover, heteroleptic polyhedral coordination enforces chemical bonding hierarchy, which, together with the stereochemically active 5 <jats:italic> s <jats:sup>2</jats:sup> </jats:italic> lone pair of Te, generates pronounced lattice anharmonicity. These effects give rise to localized low‐energy optical phonon modes, which suppress the acoustic phonons, as confirmed by phonon dispersion calculations. 5 <jats:italic> s <jats:sup>2</jats:sup> </jats:italic> lone pair driven Te‐ring puckering and lattice shearing between layers provide low‐frequency optical modes, which are experimentally identified by low‐temperature Raman spectroscopy and heat‐capacity measurements. Collectively, strong <jats:italic>p‐d*</jats:italic> antibonding interaction induced lattice softening and lone pair driven instability produce strong anharmonicity, which markedly suppresses the heat‐carrying acoustic phonons, leading to intrinsically ultralow <jats:italic>κ</jats:italic> <jats:sub>lat</jats:sub> in mixed anionic CuTe <jats:sub>2</jats:sub> Cl.","PeriodicalId":125,"journal":{"name":"Angewandte Chemie International Edition","volume":"19 1","pages":""},"PeriodicalIF":16.6,"publicationDate":"2026-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149172939","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Precision Matters: Minor Concentration Deviations of DMSO May Cause Major Efficacy Shifts","authors":"Sisi Yuan, Shang Zhu, Hang Song, Fei Wang, Zikai He, Sijie Chen, Engui Zhao","doi":"10.1002/anie.3876737","DOIUrl":"https://doi.org/10.1002/anie.3876737","url":null,"abstract":"Dimethyl sulfoxide (DMSO) represents the most common solvent for dispersing hydrophobic materials in aqueous solutions for biological usage. Generally, a DMSO content of below 1% is believed to exert no effect on cells, and thus little attention is given to its influence on drug efficacy. During our recent research on a lipid droplet‐targeted photosensitizer, PNA‐9, we notice the drastic influence of low‐concentration DMSO (&lt;1%) on its photodynamic therapy (PDT) performance. In‐depth investigations reveal the significant role of low‐concentration DMSO on PNA‐9 particle size, which further affects cellular uptake via passive diffusion and results in a drastic PDT effect. We further extend our investigation of low‐concentration DMSO effect on other common hydrophobic chemotherapy drugs and photosensitizers. The results uncover the differential influences of low‐concentration DMSO: camptothecin (CPT) and TPE‐IQ possess similar DMSO effects, whilst the therapy effects of paclitaxel (PCT), bortezomib (BTZ), and DTTPB are not obviously influenced. This work aims to bring the effect of low‐concentration DMSO to attention and is expected to benefit the development of biomaterials and comprehensive material performance evaluation.","PeriodicalId":125,"journal":{"name":"Angewandte Chemie International Edition","volume":"49 1","pages":""},"PeriodicalIF":16.6,"publicationDate":"2026-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149172940","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Crystallography‐Dependent Plating/Stripping Kinetics and Interfacial Morphologies in Zn Metal Anodes","authors":"Ziqing Wang, Debasree Mandal, Iván Elías Mondaca‐Medina, Kenta Kawashima, Rinish Reddy Vaidyula, Charles Buddie Mullins, Hang Ren, Kent J. X. Zheng","doi":"10.1002/anie.1058773","DOIUrl":"https://doi.org/10.1002/anie.1058773","url":null,"abstract":"Crystallographic orientation governs Zn deposition, dissolution, and cycling stability, but its influence on interfacial charge‐transfer kinetics remains difficult to quantify. Here, scanning electrochemical cell microscopy coupled with fast scan cyclic voltammetry (FSCV) is used to resolve Zn plating and stripping on single‐crystal (002), (100), and (101) surfaces. Meniscus‐confined measurements reveal facet‐dependent branch‐specific apparent zero‐current potentials and apparent exchange current densities, <jats:italic>j</jats:italic> <jats:sub>0</jats:sub> , with the kinetic ordering <jats:italic>j</jats:italic> <jats:sub>0</jats:sub> (100) &gt; <jats:italic>j</jats:italic> <jats:sub>0</jats:sub> (101) &gt; <jats:italic>j</jats:italic> <jats:sub>0</jats:sub> (002) for both plating and stripping. This ordering is reproduced across independently prepared electrodes and retained over different scan rates and aqueous electrolytes. Beyond charge transfer, Zn removal and regrowth are strongly crystallographically encoded: dissolution footprints preserve the symmetry of the parent facets, while potentiostatically deposited Zn adopts substrate‐dependent growth geometries. These coupled kinetic and morphological differences translate directly to battery performance. Despite its slower apparent kinetics, the close‐packed, low‐energy (002) facet exhibits the longest cycling life in Zn/Zn symmetric cells and substantially improved capacity retention in both polyaniline/Zn and Na <jats:sub>0.33</jats:sub> V <jats:sub>2</jats:sub> O <jats:sub>5</jats:sub> /Zn full cells, whereas the faster (100) and (101) interfaces fail earlier. These findings establish a facet‐dependent kinetics–stability trade‐off and show that durable Zn anodes require coordinated control of charge transfer, dissolution topology, and crystallographic reconstruction.","PeriodicalId":125,"journal":{"name":"Angewandte Chemie International Edition","volume":"30 1","pages":""},"PeriodicalIF":16.6,"publicationDate":"2026-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149172941","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Intrinsic Near‐Infrared Photothermal Effect Induces Single‐Crystal‐to‐Single‐Crystal Transformation in Organic Molecular Crystals","authors":"Liming Yang, Binjie Chen, Rushuai Deng, Xiangwei Kong, Yunze Huang, Mingxing Chen, Xinggui Gu","doi":"10.1002/anie.3462526","DOIUrl":"https://doi.org/10.1002/anie.3462526","url":null,"abstract":"Near‐infrared (NIR) light‐driven single‐crystal‐to‐single‐crystal (SCSC) transformation holds profound significance for supramolecular chemistry and smart materials, yet remains a formidable challenge in purely organic molecular crystals. Herein, we demonstrate SCSC transformation driven by the intrinsic NIR photothermal effect of a rationally designed croconium derivative CR‐DPA‐OMe, which features strong NIR absorption and a high photothermal conversion efficiency of 60%. Solvated CR‐DPA‐OMe single crystals encapsulating CHCl <jats:sub>3</jats:sub> molecules exhibit exceptional ambient stability with crystallinity preserved for over two years. Benefiting from the robust dimeric packing of croconium motifs and the conformationally flexible methoxy‐substituted diphenylamine moieties, the resulting crystals successfully reconcile long‐range lattice order with structural flexibility, thus enabling efficient SCSC transformation upon NIR photothermal stimulation. Combined density functional theory (DFT) calculations and in situ single‐crystal x‐ray diffraction analysis confirm that the transformation is driven by the synergistic interplay of photoinduced molecular conformational reorganization and photothermally‐converted heat, affording markedly faster transformation than conventional oven heating. Furthermore, tailored NIR irradiation enables spatiotemporally programmable guest release, demonstrating a remote manipulation inaccessible via macroscopic conductive heating. These findings highlight the substantial promise of NIR photothermal modulation as an emerging stimuli‐responsive strategy for precise structural engineering in molecular crystals, opening new avenues toward tailored functional material applications.","PeriodicalId":125,"journal":{"name":"Angewandte Chemie International Edition","volume":"53 1","pages":""},"PeriodicalIF":16.6,"publicationDate":"2026-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149173016","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Chiral Disulfonimide‐Catalyzed Atroposelective Iodination of (Hetero)arylamines: Generalizing the Brønsted Base Catalysis Strategy","authors":"Yi‐Lun Li, Dong‐Chen Ouyang, Binh Khanh Mai, Scott E. Denmark","doi":"10.1002/anie.7073485","DOIUrl":"https://doi.org/10.1002/anie.7073485","url":null,"abstract":"Axially chiral (atropisomeric) scaffolds are increasingly deployed in drug discovery. Atroposelective halogenation provides an attractive strategy to install axial chirality while introducing a versatile synthetic handle for the introduction of functional groups. However, atroposelective halogenation of pro‐atropisomeric (hetero)arylamines is still underdeveloped, as most strategies rely on substrate‐embedded directing groups that limit generality. Herein, we show that Brønsted base catalysis with chiral disulfonimides (DSI) enables an atroposelective iodination for aminopyrimidines and anilines, with the discovery of a novel 2,6‐di‐ <jats:italic>tert</jats:italic> ‐butylpyridine (DTBP) effect. The enantiospecific substitution of the iodine substituent highlights the synthetic utility of this method. Control experiments and density functional theory (DFT) computations rationalize the effect of DTBP and support a mechanism in which reversible electrophilic aromatic substitution generates a Wheland intermediate that undergoes irreversible, enantio‐determining deprotonation by the chiral DSI conjugate base. Distortion/interaction model (DIM) and energy‐decomposition analyses (EDA) indicate that minimized distortion of the Wheland intermediate together with favorable noncovalent interactions stabilizes the preferred transition state.","PeriodicalId":125,"journal":{"name":"Angewandte Chemie International Edition","volume":"293 1","pages":""},"PeriodicalIF":16.6,"publicationDate":"2026-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149173015","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bioinspired Adaptive Ångström-Channels in a Hydrogen-Bonded Metal–Organic Framework for Selective Water Removal From Gas Streams by Molecular Sieving Dehydration","authors":"Yingzhi He,Yunjia Jiang,Lingyao Wang,Weidong Zhu,Banglin Chen,Yuanbin Zhang","doi":"10.1002/anie.3718000","DOIUrl":"https://doi.org/10.1002/anie.3718000","url":null,"abstract":"A bioinspired hydrogen-bonded metal–organic framework ZNU-33 with adaptive Ångström-channels enables selective water recognition and mild-condition molecular sieving dehydration of light hydrocarbons and CO2.","PeriodicalId":125,"journal":{"name":"Angewandte Chemie International Edition","volume":"53 1","pages":""},"PeriodicalIF":16.6,"publicationDate":"2026-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149173107","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dynamic ZrOx Clusters Enhanced Redox Couple and ─CHO/OH− Co-Adsorption for Efficient Electrooxidation of Alcohols/Aldehydes","authors":"Shaoyu Yuan,Tao Huang,Yuke Wu,Haowei Chen,Jingjuan Wang,Yunchao Feng,Xianhai Zeng","doi":"10.1002/anie.5266205","DOIUrl":"https://doi.org/10.1002/anie.5266205","url":null,"abstract":"A strategy for enhancing the activity of electrocatalytic oxidation of alcohols and aldehydes by using ZrOx clusters as dynamic electronic regulator to modulate redox couple.","PeriodicalId":125,"journal":{"name":"Angewandte Chemie International Edition","volume":"31 1","pages":""},"PeriodicalIF":16.6,"publicationDate":"2026-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149173108","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sulfur Clusters Anchored on Carbon Enables High‐Loading, Low‐Coordination Noble Metal Cluster Catalysts for Electrocatalysis","authors":"Hong Zhao, Wenli Bao, Xiao Ren, Aiguo Zheng, Junfeng Rong, Guirong Zhang, Donghai Mei, Xikang Zhao, Xinyu Ma, Lufan Zheng, Dongli Chen, Mingzan Bai, Lin Guo, Ding Ma, Guodong Si","doi":"10.1002/anie.4211333","DOIUrl":"https://doi.org/10.1002/anie.4211333","url":null,"abstract":"A rational catalyst design demands a versatile platform integrating high intrinsic activity, optimal atomic utilization, high loading, and stability. We report an ultra‐stable three‐dimensional sulfur cluster anchored on a carbon scaffold, which forms a multi‐directional anchoring network for noble metals, effectively overcoming the inherent short‐range limitation of strong metal‐support interactions. A 40 wt% Platinum cluster catalyst with cluster size of over 1.5 nm and an average Pt–Pt coordination number of ∼3 was successfully fabricated. The resulting Pt/SCC achieved an overpotential of only 3.9 mV at 10 mA/cm <jats:sup>2</jats:sup> with a mass activity (MA) of 17.5 A/mg <jats:sub>Pt</jats:sub> in 0.5 M H <jats:sub>2</jats:sub> SO <jats:sub>4</jats:sub> , and requires just 9.9 mV at 10 mA/cm <jats:sup>2</jats:sup> and a MA of 0.47 A/mg <jats:sub>Pt</jats:sub> in 1.0 M KOH. It also shows super durability with marginal loss in activity after 100 000 cyclic voltammetry cycles in both conditions. Pt/SCC delivers exceptional atomic utilization, slashing electrolyzer Pt loading by &gt;50% without compromising long‐term durability.","PeriodicalId":125,"journal":{"name":"Angewandte Chemie International Edition","volume":"68 1","pages":""},"PeriodicalIF":16.6,"publicationDate":"2026-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149172894","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}