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A randomized clinical trial: timing of indwelling urethral catheter removal following transurethral resection of prostate 一项随机临床试验:经尿道前列腺切除术后留置导尿管拔除的时机
Future Science OA Pub Date : 2023-11-10 DOI: 10.2144/fsoa-2023-0195
Saddam Al Demour, Mohammad T Al-Zubi, Mera Ababneh, Samer F Al-Rawashdah, Muayyad Ahmad
{"title":"A randomized clinical trial: timing of indwelling urethral catheter removal following transurethral resection of prostate","authors":"Saddam Al Demour, Mohammad T Al-Zubi, Mera Ababneh, Samer F Al-Rawashdah, Muayyad Ahmad","doi":"10.2144/fsoa-2023-0195","DOIUrl":"https://doi.org/10.2144/fsoa-2023-0195","url":null,"abstract":"Aim: We aimed to evaluate early versus delayed removal of the indwelling urethral catheter (IUC) following transurethral resection of prostate (TURP). Methods: In this clinical trial conducted between July 2016 and June 2020, 90 patients underwent TURP were randomized equally into: group A, early IUC removal (24 h), and group B, delayed IUC removal (72 h). Results: The mean length of hospital stay was longer among the patients in group B. There were no significant differences in recatheterization, secondary bleeding, or UTI between groups A and B. The mean VAS score and CRBD were higher in group B. Conclusion: Early IUC removal following TURP is safe approach with favorable clinical outcomes. Clinical Trial Registration: NCT04363970 ( clinicaltrials.gov )","PeriodicalId":12568,"journal":{"name":"Future Science OA","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-11-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135141664","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Marital status impacts survival of stage I non-small-cell lung cancer: a propensity-score matching analysis 婚姻状况影响I期非小细胞肺癌的生存:倾向评分匹配分析
Future Science OA Pub Date : 2023-11-07 DOI: 10.2144/fsoa-2023-0103
Li-Hong Qiu, Jia-Qi Song, Feng Jiang, Yuan-Yuan Zhao, Yu'e Liu, Lei-Lei Wu, Guo-Wei Ma
{"title":"Marital status impacts survival of stage I non-small-cell lung cancer: a propensity-score matching analysis","authors":"Li-Hong Qiu, Jia-Qi Song, Feng Jiang, Yuan-Yuan Zhao, Yu'e Liu, Lei-Lei Wu, Guo-Wei Ma","doi":"10.2144/fsoa-2023-0103","DOIUrl":"https://doi.org/10.2144/fsoa-2023-0103","url":null,"abstract":"Aim: This population-based analysis aimed to explore the associations among marital status, prognosis and treatment of stage I non-small-cell lung cancer. Materials &amp; methods: The propensity score matching (PSM), logistic regression and Cox proportional hazards model were used in this study. Results: A total of 13,937 patients were included. After PSM, 10579 patients were co-insured. The married were more likely to receive surgical treatment compared with the unmarried patients (OR: 1.841, p < 0.001), and patients who underwent surgery also tended to have better survival (HR: 0.293, p < 0.001). Conclusion: Compared with unmarried patients, a married group with stage I NSCLC had timely treatment and more satisfactory survival. This study highlights the importance of prompt help and care for unmarried patients.","PeriodicalId":12568,"journal":{"name":"Future Science OA","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-11-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135475324","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Surgical resection due to poor outcome of the immunotherapy of a relapsed mediastinal liposarcoma: a case report 因免疫治疗效果不佳而手术切除复发性纵隔脂肪肉瘤1例
Future Science OA Pub Date : 2023-10-30 DOI: 10.2144/fsoa-2023-0099
Ming-Ji Wang, Shu-Quan Xu, Lei-Lei Wu, Zhi-Xin Li, Dong Xie
{"title":"Surgical resection due to poor outcome of the immunotherapy of a relapsed mediastinal liposarcoma: a case report","authors":"Ming-Ji Wang, Shu-Quan Xu, Lei-Lei Wu, Zhi-Xin Li, Dong Xie","doi":"10.2144/fsoa-2023-0099","DOIUrl":"https://doi.org/10.2144/fsoa-2023-0099","url":null,"abstract":"The feasibility of surgery after immunotherapy for mediastinal liposarcoma remains uncertain. Besides, the case of immunotherapy for liposarcoma is still lacking. We report a case of recurrence after resection of a left mediastinal liposarcoma. After recurrence, one course of pembrolizumab plus anlotinib hydrochloride showed no tumor shrinkage, and genetic testing showed CDK4 amplification and PD-L1 TPS <1%; therefore, the plan was changed to one course of pembrolizumab plus palbociclib, but the tumor still did not shrink. Thus, second tumor resection was performed. In addition, the postoperative pathology was still well-differentiated liposarcoma. The significance of immunotherapy in liposarcoma still needs to be further explored. In the absence of surgical contraindications, secondary surgery might be feasible.","PeriodicalId":12568,"journal":{"name":"Future Science OA","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-10-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136104083","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
In silico and pharmacokinetic assessment of echinocystic acid effectiveness in Alzheimer's disease like pathology 棘囊酸在阿尔茨海默病样病理中的作用的计算机和药代动力学评价
Future Science OA Pub Date : 2023-10-04 DOI: 10.2144/fsoa-2023-0150
Ankul Singh S, Chitra Vellapandian
{"title":"<i>In silico</i> and pharmacokinetic assessment of echinocystic acid effectiveness in Alzheimer's disease like pathology","authors":"Ankul Singh S, Chitra Vellapandian","doi":"10.2144/fsoa-2023-0150","DOIUrl":"https://doi.org/10.2144/fsoa-2023-0150","url":null,"abstract":"Aim: Alzheimer's disease causes dementia which impairs the cognitive domains. Methodology: The pharmacokinetic characteristics and biological activity of echinocystic acid are predicted in this work using in silico or computational approaches, including pkCSM, Swiss ADME, OSIRIS ® property explorer, PASS online web resource and MOLINSPIRATION ® software. Results &amp; discussion: The compound has lipid metabolism regulating property as major role in decreasing the progression of Alzheimer's disease and it has no major side effects and ADR. The drug also has anti-inflammatory properties which can help in regulating the innate immunity that plays a major role in Alzheimer's disease. Conclusion: From the computational screening, we infer that, echinocystic acid can regulate memory loss, cognitive disability and also slow down the progression of Alzheimer's disease-like pathology.","PeriodicalId":12568,"journal":{"name":"Future Science OA","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-10-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135592092","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Prognostic and clinicopathological significance of FOXD1 in various cancers: a meta and bioinformation analysis FOXD1在各种癌症中的预后和临床病理意义:meta和生物信息分析
Future Science OA Pub Date : 2023-09-07 DOI: 10.2144/fsoa-2023-0085
Xiaohan Liu, Shengyun Min, Qin Zhang, Yan Liu, Zhenhong Zou, Nanye Wang, Bin Zhou
{"title":"Prognostic and clinicopathological significance of FOXD1 in various cancers: a meta and bioinformation analysis","authors":"Xiaohan Liu, Shengyun Min, Qin Zhang, Yan Liu, Zhenhong Zou, Nanye Wang, Bin Zhou","doi":"10.2144/fsoa-2023-0085","DOIUrl":"https://doi.org/10.2144/fsoa-2023-0085","url":null,"abstract":"Aim: To examine both predictive and clinicopathological importance underlying FOXD1 in malignant tumors, our study adopts meta-analysis. Methods: We searched from PubMed, Embase, WOS, Wanfang and CNKI. Stata SE15.1 was used to calculate the risk ratio (HR) as well as relative risk (RR) with 95% of overall confidence intervals (CIs) to assess FOXD1 and overall survival rate (OS), disease-free survival rate ( FOXD1) as well as clinicopathological parameters. Results: 3808 individuals throughout 17 trials showed high FOXD1 expression was linked to disadvantaged OS (p < 0.001) and disease-free survival (p < 0.001) and higher TNM stage (p < 0.001). Conclusion: Elevated FOXD1 had worse predictions and clinicopathological parameters in most cancers. The GEPIA database findings also support our results.","PeriodicalId":12568,"journal":{"name":"Future Science OA","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-09-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135047708","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The impact of cellular environment on in vitro drug screening. 细胞环境对体外药物筛选的影响。
IF 2.5
Future Science OA Pub Date : 2023-09-07 eCollection Date: 2023-10-01 DOI: 10.2144/fsoa-2023-0027
Aiman Moldasheva, Laura Bakyt, Denis Bulanin, Mohamad Aljofan
{"title":"The impact of cellular environment on <i>in vitro</i> drug screening.","authors":"Aiman Moldasheva,&nbsp;Laura Bakyt,&nbsp;Denis Bulanin,&nbsp;Mohamad Aljofan","doi":"10.2144/fsoa-2023-0027","DOIUrl":"https://doi.org/10.2144/fsoa-2023-0027","url":null,"abstract":"<p><p>There are various reasons for drug failure in the developmental stage including toxicity, adverse effects and inefficacy. This is likely due to the differences in drug behavior between a simple and controlled cell culture system to that of a more complex whole organism environment. While the use of human phenotypical cells relevant to the condition may provide more accurate screening results, they are susceptible to producing false positives as cells are continuously influenced by constant chemical and physical interaction with the surrounding microenvironment. Therefore, several microenvironmental and pharmacomechanical aspects must be factored in during tissue culture drug screening.</p>","PeriodicalId":12568,"journal":{"name":"Future Science OA","volume":null,"pages":null},"PeriodicalIF":2.5,"publicationDate":"2023-09-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10518819/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41178508","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The increasing importance of the oral microbiome in periodontal health and disease. 口腔微生物群在牙周健康和疾病中的重要性日益增加。
IF 2.5
Future Science OA Pub Date : 2023-09-01 DOI: 10.2144/fsoa-2023-0062
Ruqaiyyah Siddiqui, Zahi Badran, Anania Boghossian, Ahmad M Alharbi, Hasan Alfahemi, Naveed Ahmed Khan
{"title":"The increasing importance of the oral microbiome in periodontal health and disease.","authors":"Ruqaiyyah Siddiqui,&nbsp;Zahi Badran,&nbsp;Anania Boghossian,&nbsp;Ahmad M Alharbi,&nbsp;Hasan Alfahemi,&nbsp;Naveed Ahmed Khan","doi":"10.2144/fsoa-2023-0062","DOIUrl":"https://doi.org/10.2144/fsoa-2023-0062","url":null,"abstract":"<p><p>Herein, the aim is to discuss the current knowledge of microbiome and periodontal diseases. Current treatment strategies include mechanical therapy such as root planing, scaling, deep pocket debridement and antimicrobial chemotherapy as an adjuvant therapy. Among promising therapeutic strategies, dental probiotics and oral microbiome transplantation have gained attention, and may be used to treat bacterial imbalances by competing with pathogenic bacteria for nutrients and adhesion surfaces, as well as probiotics targeting the gut microbiome. Development of strategies to prevent and treat periodontal diseases are warranted as both are highly prevalent and can affect human health. Further studies are necessary to better comprehend the microbiome in order to develop innovative preventative measures as well as efficacious therapies against periodontal diseases.</p>","PeriodicalId":12568,"journal":{"name":"Future Science OA","volume":null,"pages":null},"PeriodicalIF":2.5,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10445586/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10069743","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Artificial sweetener is a growing threat for metabolic syndrome: why is extra attention required? 人造甜味剂对代谢综合征的威胁越来越大:为什么需要额外的关注?
IF 2.5
Future Science OA Pub Date : 2023-09-01 DOI: 10.2144/fsoa-2023-0092
Sarvesh Sabarathinam, Dhivya Dhanasekaran, Nila Ganamurali
{"title":"Artificial sweetener is a growing threat for metabolic syndrome: why is extra attention required?","authors":"Sarvesh Sabarathinam,&nbsp;Dhivya Dhanasekaran,&nbsp;Nila Ganamurali","doi":"10.2144/fsoa-2023-0092","DOIUrl":"https://doi.org/10.2144/fsoa-2023-0092","url":null,"abstract":"Sarvesh Sabarathinam*,‡ ,1,2,3 , Dhivya Dhanasekaran‡ ,3 & Nila Ganamurali‡ ,3 1Drug testing Laboratory, Interdisciplinary Institute of Indian System of Medicine (IIISM), SRM Institute of Science & Technology, Kattankulathur, Chennai, Tamil Nadu, 603203, India 2Clinical Trial Unit, Metabolic Ward, Interdisciplinary Institute of Indian System of Medicine (IIISM), SRM Institute of Science & Technology, Kattankulathur, Chennai, Tamil Nadu, 603203, India 3Certificate Program-Analytical Techniques in Herbal Drug Industry, Interdisciplinary Institute of Indian System of Medicine (IIISM), SRM Institute of Science & Technology, Kattankulathur, Chennai, Tamil Nadu, 603203, India *Author for correspondence: sarveshtvg@gmail.com ‡Authors contributed equally","PeriodicalId":12568,"journal":{"name":"Future Science OA","volume":null,"pages":null},"PeriodicalIF":2.5,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10445552/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10075671","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Human herpesvirus-7 meningitis in an immunocompetent adult patient: a case report. 人疱疹病毒-7型脑膜炎1例免疫功能正常的成人患者:1例报告。
IF 2.5
Future Science OA Pub Date : 2023-09-01 DOI: 10.2144/fsoa-2023-0021
Rabih Fares, Madonna Matar
{"title":"Human herpesvirus-7 meningitis in an immunocompetent adult patient: a case report.","authors":"Rabih Fares,&nbsp;Madonna Matar","doi":"10.2144/fsoa-2023-0021","DOIUrl":"https://doi.org/10.2144/fsoa-2023-0021","url":null,"abstract":"<p><strong>Aim: </strong>The underlying pathological mechanisms of CNS human herpesvirus-7 (HHV-7) related infections are still unknown, especially among immunocompetent adults. Although HHV-7 meningitis in immunocompetent adults is usually uncommon, serious consideration for possible HHV-7 involvement should be taken when assessing CNS infection of unknown etiology.</p><p><strong>Case presentation: </strong>We report a 53-year-old female who presented for fever and progressive headaches. Cerebrospinal fluid (CSF) analysis was compatible with a viral meningitis. CSF cultures were negative and HHV-7 DNA was the only strain detected in the CSF analysis. The patient died 1 month later following complications and cardiac arrest.</p><p><strong>Conclusion: </strong>HHV-7 CNS infection in immunocompetent patient can be a serious infection. Prompt diagnosis and treatment management are essential for better outcome.</p>","PeriodicalId":12568,"journal":{"name":"Future Science OA","volume":null,"pages":null},"PeriodicalIF":2.5,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10445589/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10074092","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Establishment of cancer cell line originating from a patient with high-grade serous ovarian carcinoma. 高级别浆液性卵巢癌患者癌细胞系的建立。
IF 2.5
Future Science OA Pub Date : 2023-09-01 DOI: 10.2144/fsoa-2023-0025
Nguyen Thuy Linh, Ngo Thu Hang, Bui Khac Cuong, Dang Thuy Linh, Nham Thi Phuong Linh, Do Nguyen-Van, Tran Ngoc Dzung, Can Van Mao, Dang Thanh Chung, Le Tri Chinh, Nguyen Phu Hung, Hoang Van Tong, Nguyen Linh Toan
{"title":"Establishment of cancer cell line originating from a patient with high-grade serous ovarian carcinoma.","authors":"Nguyen Thuy Linh,&nbsp;Ngo Thu Hang,&nbsp;Bui Khac Cuong,&nbsp;Dang Thuy Linh,&nbsp;Nham Thi Phuong Linh,&nbsp;Do Nguyen-Van,&nbsp;Tran Ngoc Dzung,&nbsp;Can Van Mao,&nbsp;Dang Thanh Chung,&nbsp;Le Tri Chinh,&nbsp;Nguyen Phu Hung,&nbsp;Hoang Van Tong,&nbsp;Nguyen Linh Toan","doi":"10.2144/fsoa-2023-0025","DOIUrl":"https://doi.org/10.2144/fsoa-2023-0025","url":null,"abstract":"<p><strong>Aim: </strong>Ovarian cancer is a serious malignancy with high prevalence and mortality.</p><p><strong>Methods: </strong>We isolated and characterized an ovarian high-grade serous cancer cell line (M4) from a tumor of a Vietnamese patient with ovarian carcinoma.</p><p><strong>Results: </strong>The M4 cancer cell line showed good proliferation and stability in culture. Morphologically, the M4 cells showed similar characteristics to tumor cells such as a polyhedral shape, large irregular nuclei, high nuclear/cytoplasmic ratio, high nuclear density and expressing cancer markers like CA125, p53 and Ki67 markers.</p><p><strong>Conclusion: </strong>We have successfully isolated and characterized the M4 cell line from a Vietnamese patient with ovarian carcinoma.</p>","PeriodicalId":12568,"journal":{"name":"Future Science OA","volume":null,"pages":null},"PeriodicalIF":2.5,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10445588/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10075669","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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