Oxidative markers and SOD variant: predictors of autism severity and susceptibility.

IF 2.4 Q3 MEDICINE, RESEARCH & EXPERIMENTAL

Future Science OA Pub Date : 2025-12-01 Epub Date: 2025-03-31 DOI:10.1080/20565623.2025.2483628

Abdullah Abubaker Shareef, Azad Hasan Kheder, Niaz Albarzinji, Karim Jalal Karim, Shukur Wasman Smail, Abuabkr Abdalla Mahmood, Kawa Amin

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引用次数: 0

Abstract

Background: This study examines the relationship between oxidative stress, anti-oxidative markers, and the Ala16Val SOD2 polymorphism in children with autism spectrum disorder (ASD) to better understand ASD severity and susceptibility.

Material and methods: The study included 80 children (40 with ASD and 40 controls) from Erbil City, Iraq.

Results: Serum antioxidant markers, such as superoxide dismutase (SOD) and glutathione peroxidase (GPX), were significantly lower in ASD patients compared to controls (P = 0.036 and P < 0.001, respectively), while markers of oxidative damage, including malondialdehyde (MDA), nitric oxide (NO), and cytochrome C, were significantly elevated (P < 0.001). Regression analysis revealed reduced SOD and GPX activities were strongly associated with increased autism severity, as measured by the childhood autism rating scale (CARS), while elevated NO and cytochrome C levels also correlated positively with higher CARS scores. Although the Ala16Val SOD polymorphism was not significantly associated with ASD risk, logistic regression showed no connection between SOD genotypes and serum SOD levels.

Conclusion: These findings suggest oxidative stress and impaired antioxidant defense play critical roles in ASD severity.

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氧化标记物和SOD变异：自闭症严重程度和易感性的预测因子。

背景：本研究旨在探讨自闭症谱系障碍（ASD）儿童氧化应激、抗氧化标志物和Ala16Val SOD2多态性之间的关系，以更好地了解ASD的严重程度和易感性。材料和方法：本研究包括来自伊拉克埃尔比勒市的80名儿童，其中40名患有ASD， 40名对照组。结果：ASD患者血清超氧化物歧化酶（SOD）和谷胱甘肽过氧化物酶（GPX）等抗氧化指标显著低于对照组（P = 0.036和P = 0.036）。结论：氧化应激和抗氧化防御功能受损在ASD严重程度中起重要作用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Future Science OA MEDICINE, RESEARCH & EXPERIMENTAL-

CiteScore

5.00

自引率

4.00%

发文量

审稿时长

13 weeks

期刊介绍： Future Science OA is an online, open access, peer-reviewed title from the Future Science Group. The journal covers research and discussion related to advances in biotechnology, medicine and health. The journal embraces the importance of publishing all good-quality research with the potential to further the progress of research in these fields. All original research articles will be considered that are within the journal''s scope, and have been conducted with scientific rigour and research integrity. The journal also features review articles, editorials and perspectives, providing readers with a leading source of commentary and analysis. Submissions of the following article types will be considered: -Research articles -Preliminary communications -Short communications -Methodologies -Trial design articles -Trial results (including early-phase and negative studies) -Reviews -Perspectives -Commentaries