Future Science OA最新文献

Adverse predictive value of ASPM on lung adenocarcinoma overall survival depended on chemotherapy status. ASPM对肺腺癌总生存的不良预测价值依赖于化疗状态。

IF 2.4

Future Science OA Pub Date : 2025-12-01 Epub Date: 2025-04-09 DOI: 10.1080/20565623.2025.2489328

Yan Zheng, Baichen Sun, Zhiling Qu

{"title":"Adverse predictive value of ASPM on lung adenocarcinoma overall survival depended on chemotherapy status.","authors":"Yan Zheng, Baichen Sun, Zhiling Qu","doi":"10.1080/20565623.2025.2489328","DOIUrl":"10.1080/20565623.2025.2489328","url":null,"abstract":"Objective: Transcriptome and proteome analyses may yield inconsistent predictions regarding tumor prognosis. The clinical and pathological significance of ASPM expression in lung adenocarcinoma (LUAD) remains unclear. This study investigates the expression and prognostic value of ASPM, focusing on its role in chemotherapy outcomes.Methods: We analyzed the prognostic relevance of ASPM using bioinformatics, immunohistochemical staining of LUAD tissue microarrays, and proteomics data. Further, in vitro experiments were conducted to evaluate the effects of ASPM overexpression on cell proliferation and sensitivity to cisplatin.Results: Bioinformatics analysis revealed that ASPM's prognostic significance differed between transcriptomic and proteomic datasets. Immunohistochemistry showed that high ASPM expression predicted improved overall survival only in LUAD patients undergoing chemotherapy, not in those without. Proteomics analysis identified ASPM-related signatures enriched in cell cycle and mitosis pathways. In vitro, ASPM overexpression promoted tumor cell proliferation and enhanced cisplatin-induced cytotoxicity.Conclusion: ASPM exhibits a dual role in LUAD prognosis, acting as a marker for improved chemotherapy outcomes while promoting tumor proliferation. These findings underscore ASPM's potential as a therapeutic target and predictive marker for personalized treatment in LUAD.","PeriodicalId":12568,"journal":{"name":"Future Science OA","volume":"11 1","pages":"2489328"},"PeriodicalIF":2.4,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11988246/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143811072","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Tracking protein kinase targeting advances: integrating QSAR into machine learning for kinase-targeted drug discovery. 跟踪蛋白激酶靶向进展：将QSAR整合到机器学习中用于激酶靶向药物发现。

IF 2.4

Future Science OA Pub Date : 2025-12-01 Epub Date: 2025-04-04 DOI: 10.1080/20565623.2025.2483631

Rand Shahin, Sawsan Jaafreh, Yusra Azzam

{"title":"Tracking protein kinase targeting advances: integrating QSAR into machine learning for kinase-targeted drug discovery.","authors":"Rand Shahin, Sawsan Jaafreh, Yusra Azzam","doi":"10.1080/20565623.2025.2483631","DOIUrl":"10.1080/20565623.2025.2483631","url":null,"abstract":"Protein kinases are vital drug targets, yet designing selective inhibitors is challenging, compounded by resistance and kinome complexity. This review explores Quantitative Structure-Activity Relationship (QSAR) modeling for kinase drug discovery, focusing on integrating traditional QSAR with machine learning (ML)-CNNs, RNNs-and structural data. Methods include structural databases, docking, and deep learning QSAR. Key findings show ML-integrated QSAR significantly improves selective inhibitor design for CDKs, JAKs, PIM kinases. The IDG-DREAM challenge exemplifies ML's potential for accurate kinase-inhibitor interaction prediction, outperforming traditional methods and enabling inhibitors with enhanced selectivity, efficacy, and resistance mitigation. QSAR combined with advanced computation and experimental data accelerates kinase drug discovery, offering transformative precision medicine potential. This review highlights deep learning-enhanced QSAR's novelty in automating feature extraction and capturing complex relationships, surpassing traditional QSAR, while emphasizing interpretability and experimental validation for clinical translation.","PeriodicalId":12568,"journal":{"name":"Future Science OA","volume":"11 1","pages":"2483631"},"PeriodicalIF":2.4,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11980485/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143779417","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Previous immunological disease can promote neurological complications of SARS-CoV-2 infection, such as VST or GBS. 既往免疫性疾病可促进SARS-CoV-2感染的神经系统并发症，如VST或GBS。

IF 2.4

Future Science OA Pub Date : 2025-12-01 Epub Date: 2025-02-10 DOI: 10.1080/20565623.2025.2463849

Josef Finsterer

引用次数: 0

Resveratrol alleviates depressive-like behavior via the activation of SIRT1/NF-κB signaling pathway in microglia. 白藜芦醇通过激活小胶质细胞中SIRT1/NF-κB信号通路减轻抑郁样行为。

IF 2.4

Future Science OA Pub Date : 2025-12-01 Epub Date: 2025-02-18 DOI: 10.1080/20565623.2025.2463852

Yuehong Wu, Yixia Zhu, Shun Zheng, Ding Mingxing

{"title":"Resveratrol alleviates depressive-like behavior via the activation of SIRT1/NF-κB signaling pathway in microglia.","authors":"Yuehong Wu, Yixia Zhu, Shun Zheng, Ding Mingxing","doi":"10.1080/20565623.2025.2463852","DOIUrl":"10.1080/20565623.2025.2463852","url":null,"abstract":"Background: Currently, the pathogenesis of depression remains poorly understood, leading to many patients receiving ineffective treatment. Resveratrol has demonstrated beneficial effects in the prevention and treatment of depression. However, it remains unknown whether resveratrol administration can counteract depression-like behaviors by regulating the SIRT1/NF-κB signaling pathway.Methodology/principal findings: Male C57BL/6 mice were randomly assigned to a control group, a depression group, and a resveratrol group. The depression model was established using chronic unpredictable mild stress (CUMS) for 5 weeks. Behavioral tests were conducted to assess depressive-like behaviors. The expression levels of SIRT1 and NF-κB in the hippocampus of mice and BV2 microglial cells were measured. After 5 weeks of modeling, the results indicated that mice in the depression group exhibited significant depressive-like behaviors and inhibited activation of the SIRT1/NF-κB signaling pathway. In contrast, resveratrol administration effectively reversed these changes. Results from in vitro experiments showed that LPS stimulation increased microglial activity and downregulated the SIRT1/NF-κB signaling pathway in microglia; however, resveratrol treatment mitigated these effects.Conclusions/significance: Our findings suggested that resveratrol can alleviate CUMS-induced depression-like behaviors via the activation of the Sirt1/NF-κB pathway in microglia.","PeriodicalId":12568,"journal":{"name":"Future Science OA","volume":"11 1","pages":"2463852"},"PeriodicalIF":2.4,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11845112/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143448864","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Mechanistic approach and therapeutic strategies in menstrual and non-menstrual migraine. 经期和非经期偏头痛的机制方法和治疗策略。

IF 2.4

Future Science OA Pub Date : 2025-12-01 Epub Date: 2025-03-04 DOI: 10.1080/20565623.2025.2468109

Tanya Mani, Munira Murtaza, Rukaiah Fatma Begum, H Gayathri, M Sumithra

引用次数: 0

Predictors of sperm retrieval success in first-time and repeated Micro-TESE for nonobstructive azoospermia. 非阻塞性无精子症患者首次和重复Micro-TESE取精成功的预测因素。

IF 2.4

Future Science OA Pub Date : 2025-12-01 Epub Date: 2025-05-30 DOI: 10.1080/20565623.2025.2511449

Sulieman Alriyalat, Mohammad Ghassab Deameh, Hamzeh Farraj, Jad Khaled Alsmadi, Baha' Aldeen Bani Irshid, Hammam Abu Rahmeh, Ahmad Khaled Awawdeh, Mohammad Ahmad Mubarak, Ali Fawzey Ababneh, Wa'el Ahmad Bani Amer, Mohammad Al-Zubi

{"title":"Predictors of sperm retrieval success in first-time and repeated Micro-TESE for nonobstructive azoospermia.","authors":"Sulieman Alriyalat, Mohammad Ghassab Deameh, Hamzeh Farraj, Jad Khaled Alsmadi, Baha' Aldeen Bani Irshid, Hammam Abu Rahmeh, Ahmad Khaled Awawdeh, Mohammad Ahmad Mubarak, Ali Fawzey Ababneh, Wa'el Ahmad Bani Amer, Mohammad Al-Zubi","doi":"10.1080/20565623.2025.2511449","DOIUrl":"10.1080/20565623.2025.2511449","url":null,"abstract":"Introduction: Microdissection testicular sperm extraction (micro-TESE) is the preferred sperm retrieval method, although success rates vary based on factors such as age and hormone levels. We evaluate sperm retrieval outcomes in first-time and repeated micro-TESE, identifying predictors of success to guide clinical management.Material and methods: Retrospective study analyzed 152 men with nonobstructive azoospermia (NOA) who underwent micro-TESE between 2020 and 2022. Patients were grouped based on sperm retrieval outcomes, and clinical, demographic and hormonal factors were assessed. Comparisons were made between first-time and repeat micro-TESE cases.Results: Sperm retrieval rate was higher for first-time TESE cases (64.6%) than repeated TESE cases (28.8%, p < 0.01). Repeated TESE cases were older, had higher smoking rates, and exhibited significantly elevated follicle-stimulating hormone (FSH) and luteinizing hormone (LH) levels, with lower total testosterone (p < 0.01). In repeated TESE cases, no significant differences in age, smoking status or hormone levels were found between successful and failed attempts.Conclusion: First-time micro-TESE users had a significantly higher sperm retrieval rate than those undergoing repeated attempts. Repeated TESE was associated with older age, higher smoking rates and adverse hormonal profiles. Larger studies are needed to validate these findings and optimize patient selection for repeated micro-TESE.","PeriodicalId":12568,"journal":{"name":"Future Science OA","volume":"11 1","pages":"2511449"},"PeriodicalIF":2.4,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12128663/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144186857","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Efficacy of low-intensity extracorporeal shock wave therapy for erectile dysfunction: updated meta-analysis of randomized trials. 低强度体外冲击波治疗勃起功能障碍的疗效：随机试验的最新荟萃分析。

IF 2.4

Future Science OA Pub Date : 2025-12-01 Epub Date: 2025-06-11 DOI: 10.1080/20565623.2025.2511438

Kaneez Fatima, Zahra Abbas, Anjum Un-Noor, Syeda Ilsa Aaqil, Rabia Amir, Farzeen Nawaz, Summiya Zafar, Hafsa Ali, Ahmed Mustafa Rashid

引用次数: 0

Attitudes and practices toward medical literature: a cross-sectional study at LAU Medical Center-Rizk. 对医学文献的态度和做法：劳医学中心-里兹克的横断面研究。

IF 2.4

Future Science OA Pub Date : 2025-12-01 Epub Date: 2025-06-30 DOI: 10.1080/20565623.2025.2526314

Maroun Matar, Christopher Massaad, Alaa Itani, Siham Kreidly, Georges Chedid, Pascale Salameh, Hamza Nakib

{"title":"Attitudes and practices toward medical literature: a cross-sectional study at LAU Medical Center-Rizk.","authors":"Maroun Matar, Christopher Massaad, Alaa Itani, Siham Kreidly, Georges Chedid, Pascale Salameh, Hamza Nakib","doi":"10.1080/20565623.2025.2526314","DOIUrl":"10.1080/20565623.2025.2526314","url":null,"abstract":"Background: The COVID-19 pandemic led to a surge in published medical literature, making it essential for physicians to critically assess and identify credible, peer-reviewed information.Aim: This study aimed to evaluate the attitudes and knowledge of physicians and trainees regarding medical literature reading.Methods: A cross-sectional study was conducted among 156 participants (mean age = 30.65 years) at LAU Medical Center-Rizk Hospital, including medical students, research fellows, residents, and attending physicians. Participation was anonymous. Descriptive statistics, chi-square tests, and Spearman's rank correlation were used for data analysis.Results: Among the 156 participants (42% male, 57% female), attending physicians reported a higher average of weekly reading hours (2.95 hours) compared to medical students (2.10 hours). A weak positive correlation was found between age and reading time (Spearman's rho = 0.30, p < 0.05). Gender did not influence reading behaviors, as similar trends were observed across male and female participants. Additionally, no significant effect of clinical experience on reading time was noted.Conclusion: This study highlights variations in reading practices among physicians and trainees. Further research is needed to explore influencing factors and address study limitations.","PeriodicalId":12568,"journal":{"name":"Future Science OA","volume":"11 1","pages":"2526314"},"PeriodicalIF":2.4,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12218544/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144527453","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Identification of the important role of CA9 in immune infiltration and prognosis in cervical cancer. CA9在宫颈癌免疫浸润及预后中的重要作用

IF 2.4

Future Science OA Pub Date : 2025-12-01 Epub Date: 2025-07-14 DOI: 10.1080/20565623.2025.2532314

Zhi Zhao, Xin Chen, Yajuan Feng, Yiming Lei, Xihong Deng, Rubing Lin, Jiang Ling, Zhaojuan Hou, Yuanyuan Yang, Zhenyu Zhu

{"title":"Identification of the important role of CA9 in immune infiltration and prognosis in cervical cancer.","authors":"Zhi Zhao, Xin Chen, Yajuan Feng, Yiming Lei, Xihong Deng, Rubing Lin, Jiang Ling, Zhaojuan Hou, Yuanyuan Yang, Zhenyu Zhu","doi":"10.1080/20565623.2025.2532314","DOIUrl":"10.1080/20565623.2025.2532314","url":null,"abstract":"Aim: This study aimed to investigate the association between CA9 expression and the immune infiltration and prognosis of CC.Materials & methods: The GSE9750 dataset in the GEO database, the UALCAN database, and the cBioPortal of cervical squamous cell carcinoma study were used for bioinformatic analysis, followed by validation via immunohistochemistry in clinical samples.Results: Compared to normal controls, CC samples showed 1175 significantly downregulated and 698 significantly upregulated genes, respectively. Specifically, CA9 was identified among the up-regulated genes, with verification by analysis of TCGA data. The overexpression of CA9 in CC was further confirmed in clinical samples. The protein-protein interaction network results revealed that CA9 was closely associated with 12 genes, which were widely involved in cancer-related processes such as cell proliferation, migration, and metabolism. CA9 was associated with tumor histological subtypes, hypoxia scores, low immune infiltration, poor survival rate, and specific microorganisms.Conclusion: Our study indicated that CA9 was upregulated in CC and closely related to tumor immune microenvironment, thereby becoming an important prognostic factor for CC. This study highlights CA9 as a potential diagnostic and therapeutic target for the disease.","PeriodicalId":12568,"journal":{"name":"Future Science OA","volume":"11 1","pages":"2532314"},"PeriodicalIF":2.4,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12269681/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144625979","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Prognostic factors in advanced incurable HNSCC patients on palliative-intent immunotherapy-based regimen. 晚期无法治愈的恶性鳞状细胞癌患者在姑息性免疫治疗方案中的预后因素。

IF 2.1

Future Science OA Pub Date : 2025-12-01 Epub Date: 2025-08-28 DOI: 10.1080/20565623.2025.2552067

Zainab Al Maqrashi, Michelle Bradbury, Sze Wah Samuel Chan, Yazeed AlHarbi, Francesco Fazzari, Adam Gabara, Haseeb Faisal, Shadi Sadeghian, Gregory R Pond, Brandon M Meyers, Adi Kartolo, Courtney Coschi

{"title":"Prognostic factors in advanced incurable HNSCC patients on palliative-intent immunotherapy-based regimen.","authors":"Zainab Al Maqrashi, Michelle Bradbury, Sze Wah Samuel Chan, Yazeed AlHarbi, Francesco Fazzari, Adam Gabara, Haseeb Faisal, Shadi Sadeghian, Gregory R Pond, Brandon M Meyers, Adi Kartolo, Courtney Coschi","doi":"10.1080/20565623.2025.2552067","DOIUrl":"10.1080/20565623.2025.2552067","url":null,"abstract":"Background: Locally advanced unresectable or metastatic head and neck squamous cell carcinoma carries a poor prognosis with limited palliative systemic treatment options. We sought to evaluate clinic-pathological characteristics associated with favorable responses to palliative-intent immunotherapy.Methods: A retrospective cohort study was conducted of adult patients with recurrent or metastatic head and neck squamous (rmHNSCC) cell carcinoma at the Juravinski Cancer Center from 1 January 2018 to 31 December 2022. Baseline demographic and disease characteristics, treatment delivered, and outcome data were collected.Results: A total of 96 patients were identified. Median age was 61 years (75.9% male). The most common primary was oropharyngeal. The majority of patients were platinum-ineligible or refractory (61.5%). The median overall survival was 12.6 months (95% CI 6.3-15.4), and median PFS was 5.3 months (95% CI 3.8-7.8). After univariate and multivariate analyses, the systemic immune-inflammation index (SII), albumin, and BMI were identified as independently significant prognostic factors for survival.Conclusion: SII, albumin, and BMI were the strongest independent prognostic factors of overall survival in rmHNSCC patients treated with palliative immunotherapy. Future validation studies would be important, given these are inexpensive, noninvasive tests and may be potentially modifiable patient factors.","PeriodicalId":12568,"journal":{"name":"Future Science OA","volume":"11 1","pages":"2552067"},"PeriodicalIF":2.1,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12396128/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144950422","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0