Future Science OA最新文献

{"title":"Understanding breast cancer causes: insights from Jordanian women's awareness.","authors":"Ghaith B Heilat, Tahani Alwidyan, Amjad Z Alrosan, Aseel O Rataan, Khaled Alrosan, Zuheir R Al Rousan","doi":"10.1080/20565623.2026.2626432","DOIUrl":"10.1080/20565623.2026.2626432","url":null,"abstract":"<p><strong>Objective: </strong>To evaluate the awareness and understanding of breast cancer (BC) etiology among Jordanian women and identify associated demographic factors.</p><p><strong>Materials and methods: </strong>A multiregional cross-sectional survey of 381 women was conducted via online snowball sampling. BC knowledge was assessed using a translated version of the Breast Cancer Awareness Measure. Statistical analyses included univariate and bivariate tests, followed by a multivariate ordinal logistic regression to adjust for potential confounders.</p><p><strong>Results: </strong>Only 39.9% of participants demonstrated proficient comprehension of BC etiology. Knowledge correlated significantly with age, marital status, and expertise (p < 0.05). Awareness was highest among single pharmacy students; notably, 64.8% were single pharmacy students, potentially inflating overall scores. A misconception was identified: 66.1% believed a diagnosis in one breast reduces risk in the other. Age 41-50 (OR = 5.23) and holding a diploma (OR = 0.09) were significant predictors of knowledge compared to postgraduates, while marital status was not significant in the model.</p><p><strong>Conclusions: </strong>Educational backgrounds significantly influence breast cancer awareness among Jordanian women. There is an urgent need for targeted, community-based training programs to address persistent clinical misconceptions and knowledge gaps, specifically focusing on married women and individuals working or studying in non-medical fields, to improve overall public health standards nationwide.</p>","PeriodicalId":12568,"journal":{"name":"Future Science OA","volume":"12 1","pages":"2626432"},"PeriodicalIF":2.1,"publicationDate":"2026-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12893684/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146141958","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ketamine as primary anesthetic for upper limb trauma during war: a case series of 100 surgeries at Rafik Hariri University Hospital, Lebanon's National War Trauma Referral Center.","authors":"Mustapha Nahle, Miguel Nunez, Mayyas Msheik","doi":"10.1080/20565623.2026.2622334","DOIUrl":"10.1080/20565623.2026.2622334","url":null,"abstract":"<p><strong>Background: </strong>The Beirut pager explosions on September 17, 2024 resulted in mass casualties with severe upper limb trauma admitted to Rafik Hariri University Hospital (RHUH), Lebanon's national war trauma referral center. Initial opioid-based anesthesia was associated with postoperative respiratory complications and high opioid requirements. Ketamine became available the following day through the International Committee of the Red Cross (ICRC). This study evaluates the transition to ketamine as a primary anesthetic and its effects on pain control, hemodynamics, respiration, and opioid use.</p><p><strong>Methods: </strong>We retrospectively reviewed 100 hand and finger amputation surgeries. Patients initially received fentanyl intraoperatively and opioids postoperatively. Ketamine was subsequently introduced as the primary anesthetic. Pain was assessed using the Visual Analog Scale (VAS), while respiratory and hemodynamic parameters were monitored perioperatively.</p><p><strong>Results: </strong>Ketamine was associated with significantly lower VAS scores (3.2 vs 7.8; p < 0.001), no respiratory complications (0 vs 18 cases), stable mean arterial pressure in 94% of patients, and reduced postoperative opioid use (5% vs 65%).</p><p><strong>Conclusion: </strong>Ketamine is a safe, effective, opioid-sparing anesthetic and should be prioritized in conflict and resource-limited trauma settings.</p>","PeriodicalId":12568,"journal":{"name":"Future Science OA","volume":"12 1","pages":"2622334"},"PeriodicalIF":2.1,"publicationDate":"2026-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12885423/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146112829","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Body shape concerns among Jordanian university students: prevalence, correlates, and association with social media use.","authors":"Hadeel Heilat, Shuja Mashagba, Mosab Said, Ronza Nemrawi, Fadi Alkhawaja, Eman Al-Refai, Mohammad AlElaimat, Saleh Bani Nassr, Dima Oudat","doi":"10.1080/20565623.2025.2601632","DOIUrl":"10.1080/20565623.2025.2601632","url":null,"abstract":"<p><strong>Background: </strong>Body shape concerns (BSC) and body dissatisfaction represent emerging public health issues, yet evidence from Middle Eastern contexts, including Jordan, remains limited. These concerns adversely affect psychological health and are shaped by sociocultural pressures and digital media exposure.</p><p><strong>Methods: </strong>A cross-sectional study was conducted among 418 undergraduate university students in Northern Jordan. Participants completed the Body Shape Questionnaire-8D (BSQ-8D) to assess BSC. Demographic, behavioral, and media use variables were analyzed to identify correlations.</p><p><strong>Results: </strong>Among 418 respondents (96% aged 17-24; 53% female), 73% reported no BSC. Higher levels of BSC were significantly associated with increased body mass index (BMI) (<i>p</i> < 0.001). Compared to normal-weight peers, overweight students had higher odds of reporting mild [adjusted odds ratio (AOR: 3.7)]and moderate to marked (AOR: 2.56) BSC. Parental education and social media use were also significant factors. Students who did not use Snapchat (AOR = 2.05), did not use TikTok (AOR = 2.15), and cigarette smokers (AOR = 2.75) had higher odds of reporting elevated BSC levels.</p><p><strong>Conclusions: </strong>BSC among Jordanian university students is shaped by multiple psychosocial and behavioral factors, with BMI emerging as the strongest predictor. Findings underscore the need for culturally informed strategies addressing weight stigma, smoking, parental influences, and media engagement. Integrating BSC screening into routine healthcare may support early detection of at-risk groups.</p>","PeriodicalId":12568,"journal":{"name":"Future Science OA","volume":"12 1","pages":"2601632"},"PeriodicalIF":2.1,"publicationDate":"2026-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12710888/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145741976","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Combined impact of diabetes mellitus and hypertension on acute kidney injury and survival in critically ill patients: a decade of experience from a Jordanian Tertiary Hospital.","authors":"Nosayba Al-Azzam, Sayer Al-Azzam, Reema Karasneh","doi":"10.1080/20565623.2026.2638366","DOIUrl":"10.1080/20565623.2026.2638366","url":null,"abstract":"<p><strong>Aims: </strong>To examine the independent and combined effects of diabetes mellitus (DM) and hypertension (HTN) on acute kidney injury (AKI) and 90-day mortality in critically ill patients.</p><p><strong>Patients and methods: </strong>We retrospectively analyzed 3,282 adult intensive care unit (ICU) admissions to King Abdullah University Hospital, Jordan (2012-2022). Patients were stratified by DM and HTN status. Logistic regression identified predictors of AKI, and Cox proportional hazards models assessed 90-day mortality.</p><p><strong>Results: </strong>AKI occurred in 44.7% of DM patients versus 40.8% without DM (<i>p =</i> 0.0423). Patients with both DM and HTN had the highest AKI incidence (48.6%) and the highest 90-day mortality (37.8%). In addition, the HTN × DM interaction was a significant predictor of AKI in multivariable analysis (OR = 1.18, 95% CI: 1.07-1.36, <i>p =</i> 0.0059) and increased the mortality hazard independently (HR = 1.43, 95% CI: 1.04-1.97, <i>p =</i> 0.0286).</p><p><strong>Conclusions: </strong>DM is associated with increased AKI and mortality in critically ill patients, and concurrent HTN further amplifies these risks. These findings support integrated cardiometabolic risk assessment in ICU settings.</p>","PeriodicalId":12568,"journal":{"name":"Future Science OA","volume":"12 1","pages":"2638366"},"PeriodicalIF":2.1,"publicationDate":"2026-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12969735/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147354696","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Multi-omics analysis identified SPRR2D as a potential biomarker for tumor prognosis and immune microenvironment infiltration: a pan-cancer perspective.","authors":"Yuan-Xiang Shi","doi":"10.1080/20565623.2026.2653101","DOIUrl":"10.1080/20565623.2026.2653101","url":null,"abstract":"<p><strong>Background: </strong>Clarification of the molecular mechanism of malignant tumor progression, identification of the key signaling pathways and molecules involved in the processes of invasion and metastasis, and identification of new targets and strategies for effective tumor treatment are extremely important for scientific research and clinical application prospects.</p><p><strong>Methods: </strong>Based on large-sample data mining, we first evaluated the expression and mutation profiles of SPRR family genes across cancers and then focused on the molecular functions of SPRR2D across cancers.</p><p><strong>Results: </strong>Multi-omics experiments revealed that SPRR2D is significantly overexpressed in various tumors, especially in LUSC. ROC curve analysis revealed that SPRR2D demonstrated significant diagnostic efficacy across cancers. Cox regression analysis revealed that the expression of SPRR2D was associated with the survival time of patients with various tumors. Moreover, the expression of SPRR2D is closely related to tumor immune infiltration. GDSC data analysis revealed that the expression levels of SPRR1A, SPRR1B, SPRR2A, SPRR3, and SPRR2D are negatively correlated with the sensitivity to gefitinib, trametinib, bosutinib, afatinib, lapatinib, and erlotinib.</p><p><strong>Conclusions: </strong>From a multi-omics perspective, it was revealed that SPRR2D plays a significant role in regulating tumorigenesis and drug sensitivity in tumors.</p>","PeriodicalId":12568,"journal":{"name":"Future Science OA","volume":"12 1","pages":"2653101"},"PeriodicalIF":2.1,"publicationDate":"2026-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13051589/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147615756","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Novel male contraceptives.","authors":"Jacqueline Quinn, John J Reynolds-Wright","doi":"10.1080/20565623.2026.2664612","DOIUrl":"10.1080/20565623.2026.2664612","url":null,"abstract":"<p><p>Male contraception is relied upon by many couples around the world in the form of condoms, vasectomy, and withdrawal. Novel male contraceptives are a collection of interventions in development including hormonal, non-hormonal, immunological and reversible vas-occlusive methods. A large multinational trial of a novel hormonal contraceptive has recently concluded, and while the results are awaited, this narrative review discusses the field and potential methods on the horizon.</p>","PeriodicalId":12568,"journal":{"name":"Future Science OA","volume":"12 1","pages":"2664612"},"PeriodicalIF":2.1,"publicationDate":"2026-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13134417/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147768863","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ginger-derived nanoparticles targeting NF-κB mediated inflammatory pathways: a systematic review of in vitro and in vivo evidence.","authors":"Ayunita Tri Wirattami, Kusworini Handono, Edi Handoko, Dian Nugrahenny","doi":"10.1080/20565623.2026.2657522","DOIUrl":"https://doi.org/10.1080/20565623.2026.2657522","url":null,"abstract":"<p><strong>Background: </strong>Nuclear factor kappa B (NF-κB) is a key regulator of inflammatory responses involved in chronic inflammatory diseases. Bioactive compounds from ginger (<i>Zingiber officinale</i>) inhibit NF-κB signaling but are limited by poor bioavailability. This systematic review aimed to evaluate experimental evidence on the modulatory effects of ginger-derived nanoparticles on NF-κB mediated inflammatory signaling.</p><p><strong>Methods: </strong>Eligible studies included peer-reviewed English preclinical in vitro and in vivo studies assessing ginger-derived nanoparticles targeting NF-κB mediated inflammation; reviews, clinical studies, and non-nanoparticle ginger formulations were excluded. Databases searched were PubMed, ScienceDirect, SpringerLink, the Cochrane Library, Scopus, Web of Science, and Embase (January 2010 to August 2025). Risk of bias was assessed using SYRCLE, SciRAP, and MISEV 2018 tools, and findings were narratively synthesized due to methodological heterogeneity.</p><p><strong>Results: </strong>Seven preclinical studies were included. Ginger-derived nanoparticles consistently suppressed canonical NF-κB signaling by inhibiting IκBα phosphorylation and p65 nuclear translocation, reducing pro-inflammatory cytokines (TNF-α, IL-6, IL-1β), oxidative stress, and tissue inflammation. Evidence was limited by small study numbers, heterogeneous nanoparticle formulations, and reliance on preclinical data, preventing meta-analysis.</p><p><strong>Conclusion: </strong>Ginger-derived nanoparticles represent a promising experimental strategy for modulating inflammatory signaling pathways in preclinical models.</p><p><strong>Protocol registration: </strong>PROSPERO (CRD420261337393).</p>","PeriodicalId":12568,"journal":{"name":"Future Science OA","volume":"12 1","pages":"2657522"},"PeriodicalIF":2.1,"publicationDate":"2026-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13108343/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147768943","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of a multi-component dietary supplement combined with probiotic and omega-3 in individuals with self-reported symptoms of brain fog: an 8-week exploratory study.","authors":"Abeer M Al-Ghananeem, Debbie T Combs Cantrell, Dennis Song, Ammar Jairoun","doi":"10.1080/20565623.2026.2654776","DOIUrl":"10.1080/20565623.2026.2654776","url":null,"abstract":"<p><strong>Aims: </strong>This study used an open-label design, comprising a one-arm eight-weeks-long study, and aimed to evaluate patient satisfaction and the efficacy of a novel dietary supplement composition combined with probiotic and omega-3 to support brain health improvement in 39 participants with confirmed or suspected brain fog caused by trauma, disease, exposure to chemotherapeutics, or similar events.</p><p><strong>Methods: </strong>The primary measure was the change from baseline in survey scores of the Montreal Cognitive Assessment. The secondary outcome was the change from baseline in test scores of the self-reported survey.</p><p><strong>Results: </strong>The results indicated significant improvements across all domains over time (p < 0.0001), with the most substantial changes occurring by Week 8. Repeated-measures analysis of variance showed a significant time effect (F [2.811, 105.4] = 43.09, p < 0.0001), suggesting that cognitive scores progressively improved across the weeks.</p><p><strong>Conclusions: </strong>This exploratory research indicates that the trial kit was feasible, well tolerated, and associated with improvements in exploratory cognitive measures and perceived well-being over an eight-week period, although practice and placebo effects cannot be ruled out. The findings are hypothesis-generating and support further evaluations in randomized, placebo-controlled studies using well-characterized interventions, objective adherence measures, and biomarker-based outcomes.</p>","PeriodicalId":12568,"journal":{"name":"Future Science OA","volume":"12 1","pages":"2654776"},"PeriodicalIF":2.1,"publicationDate":"2026-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13078196/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147653918","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Episiotomy practice and perineal outcomes in low risk vaginal deliveries: comparing a hospital attached birth center and delivery suite in Beirut, Lebanon.","authors":"Charlotte El Hajjar, Mohammed Zaatari, Georges Yared, Manal Dahrouj, Abdullah Kadhim, Ahmad Sabbagh, Issam Hijazi, Julia Ftouny, Christopher Massaad, Kariman Ghazal","doi":"10.1080/20565623.2026.2657529","DOIUrl":"10.1080/20565623.2026.2657529","url":null,"abstract":"<p><p><b>Background:</b> Episiotomy is considered a protective intervention when used selectively rather than routinely. Although current obstetric practice no longer recommends routine episiotomy, data on its use remain limited, particularly in Lebanon.</p><p><p><b>Objective:</b> This study evaluated the prevalence, predictors, and maternal outcomes of episiotomy in low-risk vaginal deliveries and compared its use between a hospital-attached birth center (BC) and a delivery suite (DS).</p><p><p><b>Methods:</b> A retrospective observational study was conducted using data from Rafik Hariri University Hospital (RHUH) BC and DS between January 2024 and September 2025. A total of 333 patients were included. Data were analyzed using SPSS v23. Binary logistic regression identified predictors of episiotomy, while associations with maternal outcomes were assessed using risk ratios and number needed to treat.</p><p><p><b>Results:</b> The episiotomy rate was 28.5%, with no significant difference between BC and DS. Rates were higher among primiparous women. Episiotomy was associated with lower rates of perineal injury overall (NNT = 4 for both parity groups). Among primiparous women, those without episiotomy had significantly higher rates of paraurethral injury (41.2 vs 12.3%, <i>p</i> = 0.011) and first-degree tears (35.3 vs 11.0%). On multivariate logistic regression, independent predictors of episiotomy included primiparity (aOR = 39.18, 95%, CI 18.42-83.33), private patient status (aOR = 21.72, 95%, CI 3.33-141.64), older age (aOR = 0.93, 95% CI: 0.86-0.99), and greater cervical dilation at admission (aOR = 0.74, 95% CI: 0.60-0.91).</p><p><p><b>Conclusion:</b> Episiotomy use varies by case and remains common in low-risk pregnancies, especially among primiparous women. Predictive and preventive factors associated with its use were identified.</p>","PeriodicalId":12568,"journal":{"name":"Future Science OA","volume":"12 1","pages":"2657529"},"PeriodicalIF":2.1,"publicationDate":"2026-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13094207/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147716467","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Potential pathogenesis of <i>Helicobacter pylori</i> strains from Cameroon: seroprevalence of 10 proteins involved in the pathogenesis of <i>Helicobacter pylori</i>-related gastro-duodenal diseases, measured using a new multiplex immunoassay among <i>Helicobacter pylori</i> IgM-positive dyspeptic patients.","authors":"Viny Adrien Fouomene Kenne, Laure Brigitte Kouitcheu Mabeku","doi":"10.1080/20565623.2026.2657525","DOIUrl":"10.1080/20565623.2026.2657525","url":null,"abstract":"<p><strong>Background: </strong>This study aims to evaluate the seroprevalence of <i>Helicobacter pylori</i> (<i>H. pylori)</i> proteins involved in its pathogenicity among <i>H. pylori</i> infected patients.</p><p><strong>Research design and methods: </strong>The analyses were based on 272 serums from <i>H. pylori</i> IgM-positive dyspeptic patients. <i>H. pylori</i> GroEL, FliD, HpaA, gGT, CagA, VacA, NapA, CtkA, HtrA, and HP0231 proteins was detected using multiplex serology method. The detected <i>H. pylori</i> antigens were classified as antigens for colonization, chaperone systems, immunomodulatory factors and toxins/effectors delivery/T4SS-related support factors.</p><p><strong>Results: </strong><i>H. pylori</i> CagA, VacA, FliD, HpaA, GroEL gGT, HtrA, HP0231, CtkA, and NapA proteins were present in 97.1, 77.2, 77.2, 73.2, 61, 34.2, 25.4, 18.8, 11.4, and 9.9%. Antigens involved in colonization, immune response, proteins chaperone, and toxins/effectors and T4SS-related support factors were detected in 81.9%, 19.8%, 70.5%, and 10.6%, respectively. Significant high sensitivity of virulence antigens was recorded among patients aged more than 20 years old, those from west region, male, blood group O, and overweight/obese patients.</p><p><strong>Conclusion: </strong>Our results showed that <i>H. pylori</i> strains in our milieu have a strong ability to colonize the gastric mucosa, but a low carcinogenic potential due to the scarcity of the proteins modulating the detrimental effect of CagA/VacA proteins.</p>","PeriodicalId":12568,"journal":{"name":"Future Science OA","volume":"12 1","pages":"2657525"},"PeriodicalIF":2.1,"publicationDate":"2026-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13094212/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147722536","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}