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Validation of salivary proteomic biomarkers for early detection of oral cancer in the Egyptian population.
IF 2.4
Future Science OA Pub Date : 2025-12-01 Epub Date: 2024-12-06 DOI: 10.1080/20565623.2024.2432222
Dalia Ghalwash, Ahmed Ammar, Asmaa Abou-Bakr, Al-Hassan Diab, Ayman El-Gawish
{"title":"Validation of salivary proteomic biomarkers for early detection of oral cancer in the Egyptian population.","authors":"Dalia Ghalwash, Ahmed Ammar, Asmaa Abou-Bakr, Al-Hassan Diab, Ayman El-Gawish","doi":"10.1080/20565623.2024.2432222","DOIUrl":"10.1080/20565623.2024.2432222","url":null,"abstract":"<p><strong>Purpose: </strong>The present study evaluated the sensitivity and specificity of important proteomic salivary biomarkers; IL-6, IL-8, and sCD44 in the early detection of oral cancer, and any possible associations with risk factors of oral cancer in an Egyptian population.</p><p><strong>Methods: </strong>The present investigation was conducted on 100 individuals; 25 healthy controls, 25 patients having oral potentially malignant disorders (OPMDs) with dysplasia; 25 patients having OPMDs without dysplasia, and 25 oral cancer patients. Demographic data modified gingival index, oral hygiene level, and salivary levels of the biomarkers were assessed.</p><p><strong>Results: </strong>Salivary levels of IL-6, IL-8, and sCD44 progressively increased with increased disease severity. Salivary IL-8 and IL-6 levels possess a discriminating potential from normal tissue through different degrees of dysplasia to oral cancer, sCD44 levels had a discriminating power between normal and dysplastic tissues with high sensitivity and specificity. A positive correlation was found between the three biomarkers and the grade of oral squamous cell carcinoma (OSCC) and with different risk factors.</p><p><strong>Conclusion: </strong>This is the first study that evaluated multiple salivary proteomic biomarkers in the Egyptian population, and the results validate the ability of IL-6, IL-8, and sCD44 to be used as sensitive diagnostic and prognostic biomarkers for screening and early detection of oral cancer.</p>","PeriodicalId":12568,"journal":{"name":"Future Science OA","volume":"11 1","pages":"2432222"},"PeriodicalIF":2.4,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11633404/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142784617","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Case report: lichen planus in a patient with ulcerative colitis receiving sulfasalazine: a drug effect or a disease manifestation?
IF 2.4
Future Science OA Pub Date : 2025-12-01 Epub Date: 2024-12-05 DOI: 10.1080/20565623.2024.2432240
Ahmed Mohamed Nefzi, Haythem Yacoub, Asmahane Souissi, Hajer Hassine, Dhouha Cherif, Habiba Debbabi, Héla Kchir, Nadia Maamouri
{"title":"Case report: lichen planus in a patient with ulcerative colitis receiving sulfasalazine: a drug effect or a disease manifestation?","authors":"Ahmed Mohamed Nefzi, Haythem Yacoub, Asmahane Souissi, Hajer Hassine, Dhouha Cherif, Habiba Debbabi, Héla Kchir, Nadia Maamouri","doi":"10.1080/20565623.2024.2432240","DOIUrl":"10.1080/20565623.2024.2432240","url":null,"abstract":"<p><p>Lichen Planus is an inflammatory skin disease that has been reported to be associated with inflammatory diseases like Inflammatory Bowel Disease or with medication use such as sulfasalazine. We report a case of lichen planus in a 62-year-old patient with ulcerative colitis receiving sulfasalazine. Within three years of treatment, the patient developed an erythematous rash on her forehead and wrists, which gradually worsened and spread to her arms, forearms, neck, and upper back. Lichen planus was suspected and later confirmed through histopathological examination. Consequently, sulfasalazine was discontinued, leading to partial resolution of the skin lesions. Our case highlights the importance of a thorough patient interview, as the timeline of skin lesions in relation to medication use and disease activity.</p>","PeriodicalId":12568,"journal":{"name":"Future Science OA","volume":"11 1","pages":"2432240"},"PeriodicalIF":2.4,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11622799/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142779860","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Biomarkers of mature neuronal differentiation and related diseases. 成熟神经元分化及相关疾病的生物标志物
IF 2.4
Future Science OA Pub Date : 2024-12-31 Epub Date: 2024-10-21 DOI: 10.1080/20565623.2024.2410146
Xiaodong Yuan, Wen Li, Qi Yan, Ya Ou, Qingxi Long, Pingshu Zhang
{"title":"Biomarkers of mature neuronal differentiation and related diseases.","authors":"Xiaodong Yuan, Wen Li, Qi Yan, Ya Ou, Qingxi Long, Pingshu Zhang","doi":"10.1080/20565623.2024.2410146","DOIUrl":"10.1080/20565623.2024.2410146","url":null,"abstract":"<p><p>The nervous system regulates perception, cognition and behavioral responses by serving as the body's primary communication system for receiving, regulating and transmitting information. Neurons are the fundamental structures and units of the nervous system. Their differentiation and maturation processes rely on the expression of specific biomarkers. Neuron-specific intracellular markers can be used to determine the degree of neuronal maturation. Neuronal cytoskeletal proteins dictate the shape and structure of neurons, while synaptic plasticity and signaling processes are intricately associated with neuronal synaptic markers. Furthermore, abnormal expression levels of biomarkers can serve as diagnostic indicators for nervous system diseases. This article reviews the markers of mature neuronal differentiation and their relationship with nervous system diseases.</p>","PeriodicalId":12568,"journal":{"name":"Future Science OA","volume":"10 1","pages":"2410146"},"PeriodicalIF":2.4,"publicationDate":"2024-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11497955/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142462781","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Liver biopsy revealing anti-neutrophil cytoplasmic antibody-associated vasculitis: a tale for a challenging diagnosis. 肝活检发现抗中性粒细胞胞浆抗体相关性血管炎：一个具有挑战性诊断的故事。
IF 2.4
Future Science OA Pub Date : 2024-12-31 Epub Date: 2024-08-07 DOI: 10.2144/fsoa-2023-0222
Bahaeddine Lahbacha, Abir Chaabane, Wafa Garbouj, Roua Mankai, Amina Bani, Amal Khsiba, Raja Amri, Salwa Nechi, Emna Chelbi
{"title":"Liver biopsy revealing anti-neutrophil cytoplasmic antibody-associated vasculitis: a tale for a challenging diagnosis.","authors":"Bahaeddine Lahbacha, Abir Chaabane, Wafa Garbouj, Roua Mankai, Amina Bani, Amal Khsiba, Raja Amri, Salwa Nechi, Emna Chelbi","doi":"10.2144/fsoa-2023-0222","DOIUrl":"10.2144/fsoa-2023-0222","url":null,"abstract":"<p><p>A 62-year-old woman presented with a chronic fever and fatigue. Biological investigations showed leukocytosis and elevation of acute phase markers. Liver blood tests showed deterioration with both cholestatic and hepatocellular patterns (there were, respectively, elevations in serum alkaline phosphatase levels as well as in serum alanine and aspartate aminotransferases). Viral serologies were negative. Mycobacterial infection and endocarditis were excluded. Results from blood cultures were negative. Autoantibody tests including ANCA (anti-neutrophil cytoplasmic antibody), anti-nuclear, anti-smooth muscle and anti-mitochondria were all negative. A liver biopsy revealed epithelioid granulomatous necrotizing vasculitis. Subsequently, immunological testing was repeated revealing MPO-ANCA (myeloperoxidase-ANCA). A diagnosis of ANCA-associated vasculitis with liver involvement was then made. The patient was started on steroids and her clinical state gradually improved.</p>","PeriodicalId":12568,"journal":{"name":"Future Science OA","volume":"10 1","pages":"2340262"},"PeriodicalIF":2.4,"publicationDate":"2024-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11318729/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141897250","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Cytokine release syndrome caused by immune checkpoint inhibitors: a case report and literature review. 免疫检查点抑制剂引起的细胞因子释放综合征：病例报告和文献综述。
IF 2.4
Future Science OA Pub Date : 2024-12-31 Epub Date: 2024-11-22 DOI: 10.1080/20565623.2024.2422786
Xiuping Zhang, Yang You, Pengfei Zhang, Yan Wang, Feng Shen
{"title":"Cytokine release syndrome caused by immune checkpoint inhibitors: a case report and literature review.","authors":"Xiuping Zhang, Yang You, Pengfei Zhang, Yan Wang, Feng Shen","doi":"10.1080/20565623.2024.2422786","DOIUrl":"10.1080/20565623.2024.2422786","url":null,"abstract":"<p><p>Immune checkpoint inhibitors (ICIs) have gained widespread application in the treatment of malignant tumors. Cytokine release syndrome (CRS) is a systemic inflammatory response triggered by various factors, including infections and immunotherapy. We present a case of CRS occurring in a gastric cancer patient after receiving combination therapy of tislelizumab, anlotinib and combination of capecitabine and oxaliplatin. Nineteen days after the third dose of tislelizumab, the patient experienced sudden unconsciousness, frothing at the mouth, convulsions and other clinical manifestations resembling epileptiform seizures. Elevated inflammatory markers, cytokine levels and ferritin were markedly increased. Given the absence of definite clinical evidence for metastasis and infection, the diagnosis of CRS was considered. Subsequent management with glucocorticoids and intravenous immunoglobulin resulted in the patient's improvement. However, antitumor therapy was halted, ultimately leading to death. The administration of ICIs can incite CRS, a severe, rapidly progressing condition with a poor prognosis, demanding clinical attention. Cytokines play a dual role in the pathophysiology of immune-related adverse events by mediating self-tolerance attenuation and enhancing the activation of cytotoxic T cells in the antitumor process of ICIs. The therapy of glucocorticoids combined with cytokine inhibitors may become an effective remedy.</p>","PeriodicalId":12568,"journal":{"name":"Future Science OA","volume":"10 1","pages":"2422786"},"PeriodicalIF":2.4,"publicationDate":"2024-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11587866/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142686499","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Imperative role of adaptor proteins in macrophage toll-like receptor signaling pathways. 适配蛋白在巨噬细胞收费样受体信号通路中的重要作用
IF 2.4
Future Science OA Pub Date : 2024-12-31 Epub Date: 2024-09-09 DOI: 10.1080/20565623.2024.2387961
Aurelia Rughetti, Shreya Bharti, Rajkumar Savai, Spyridoula Barmpoutsi, Andreas Weigert, Rajat Atre, Faaiza Siddiqi, Rahul Sharma, Rakhi Khabiya, Nik Hirani, Mirza S Baig
{"title":"Imperative role of adaptor proteins in macrophage toll-like receptor signaling pathways.","authors":"Aurelia Rughetti, Shreya Bharti, Rajkumar Savai, Spyridoula Barmpoutsi, Andreas Weigert, Rajat Atre, Faaiza Siddiqi, Rahul Sharma, Rakhi Khabiya, Nik Hirani, Mirza S Baig","doi":"10.1080/20565623.2024.2387961","DOIUrl":"10.1080/20565623.2024.2387961","url":null,"abstract":"<p><p>Macrophages are integral part of the body's defense against pathogens and serve as vital regulators of inflammation. Adaptor molecules, featuring diverse domains, intricately orchestrate the recruitment and transmission of inflammatory responses through signaling cascades. Key domains involved in macrophage polarization include Toll-like receptors (TLRs), Src Homology2 (SH2) and other small domains, alongside receptor tyrosine kinases, crucial for pathway activation. This review aims to elucidate the enigmatic role of macrophage adaptor molecules in modulating macrophage activation, emphasizing their diverse roles and potential therapeutic and investigative avenues for further exploration.</p>","PeriodicalId":12568,"journal":{"name":"Future Science OA","volume":"10 1","pages":"2387961"},"PeriodicalIF":2.4,"publicationDate":"2024-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11385170/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142153612","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Incidence of hematologic cancer types in Japan by ICD-O-3 code: analysis of National Cancer Registry. 按 ICD-O-3 编码划分的日本血液肿瘤类型发病率：全国癌症登记处分析。
IF 2.4
Future Science OA Pub Date : 2024-12-31 Epub Date: 2024-10-17 DOI: 10.1080/20565623.2024.2413801
Ayako Muramatsu, Tetsuji Kawakami
{"title":"Incidence of hematologic cancer types in Japan by ICD-O-3 code: analysis of National Cancer Registry.","authors":"Ayako Muramatsu, Tetsuji Kawakami","doi":"10.1080/20565623.2024.2413801","DOIUrl":"10.1080/20565623.2024.2413801","url":null,"abstract":"<p><p><b>Aim:</b> We classified subtypes of hematologic cancer in Japan's National Cancer Registry (NCR) in 2016 by ICD-O-3 code and compared numbers with the Japanese Society of Hematology's Blood Diseases Registry (BDR).<b>Materials & methods:</b> We reviewed data for individual cases, and calculated incidence per 100,000.<b>Results:</b> NCR reported 67,919 cases of hematological cancer, including diffuse large B-cell lymphoma, Not Otherwise Specified (NOS) (11.07 per 100,000), plasma cell myeloma (5.26/100,000), myelodysplastic syndrome, NOS (3.92/100,000), malignant lymphoma, NOS (3.03/100,000), marginal zone B-cell lymphoma, NOS (2.52/100,000) and follicular lymphoma, grade 1 (1.43/100,000). Around 48% of NCR cancers were also reported in the Blood Diseases Registry.<b>Conclusion:</b> ICD-O-3 codes revealed 12,365 additional cases to the 55,554 reported publicly. Accurately updated data are necessary for medical resource planning.</p>","PeriodicalId":12568,"journal":{"name":"Future Science OA","volume":"10 1","pages":"2413801"},"PeriodicalIF":2.4,"publicationDate":"2024-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11495515/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142462783","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Evaluation of the efficacy of triazavirin versus oseltamivir in management of COVID-19. 评估三唑韦林与奥司他韦在治疗 COVID-19 中的疗效。
IF 2.4
Future Science OA Pub Date : 2024-12-31 Epub Date: 2024-11-14 DOI: 10.1080/20565623.2024.2418798
Sara Samir Mohamed Elmenshawy, Mohamed Farouk Ahmed Abdelsalam, Tarek Refaat El Nagdy, Mohamed Abdel Salam Elgohary, Nagwa Ali Sabri, Amal El-Kholy
{"title":"Evaluation of the efficacy of triazavirin versus oseltamivir in management of COVID-19.","authors":"Sara Samir Mohamed Elmenshawy, Mohamed Farouk Ahmed Abdelsalam, Tarek Refaat El Nagdy, Mohamed Abdel Salam Elgohary, Nagwa Ali Sabri, Amal El-Kholy","doi":"10.1080/20565623.2024.2418798","DOIUrl":"10.1080/20565623.2024.2418798","url":null,"abstract":"<p><p><b>Aim:</b> To compare the safety and efficacy of triazavirin (TZV) 250 mg capsules versus oseltamivir 75 mg capsules in the treatment of individuals diagnosed with COVID-19.<b>Materials & methods:</b> A double-blind, randomized, interventional pilot study was conducted in a parallel design with a 7-day treatment period.<b>Results:</b> The results showed that TZV is superior to oseltamivir regarding length of hospital stay, days until clinical symptoms improvement, and cure of chest pneumonia.<b>Discussion:</b> Different literature data indicate the superiority of TZV in treating COVID-19 when compared with other therapeutic agents. While there is controversy about the efficacy of oseltamivir.<b>Conclusion:</b> It was concluded that TZV is more effective than oseltamivir in the management of COVID-19 disease.<b>Trial registration number:</b> NCT04973462.</p>","PeriodicalId":12568,"journal":{"name":"Future Science OA","volume":"10 1","pages":"2418798"},"PeriodicalIF":2.4,"publicationDate":"2024-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11572151/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142618292","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Endoscope disinfectant-induced colonic pseudolipomatosis: case series of a rare condition. 内窥镜消毒剂诱发的结肠假脂瘤病：罕见病例系列。
IF 2.5
Future Science OA Pub Date : 2024-12-31 Epub Date: 2024-06-12 DOI: 10.2144/fsoa-2023-0210
Charfeddine Baccouche, Myriam Ayari, Imen Abdelaali, Amen Dhaoui, Taieb Jomni, Mohamed Hedi Douggui
{"title":"Endoscope disinfectant-induced colonic pseudolipomatosis: case series of a rare condition.","authors":"Charfeddine Baccouche, Myriam Ayari, Imen Abdelaali, Amen Dhaoui, Taieb Jomni, Mohamed Hedi Douggui","doi":"10.2144/fsoa-2023-0210","DOIUrl":"10.2144/fsoa-2023-0210","url":null,"abstract":"<p><p><b>Aim:</b> Colonic mucosal pseudolipomatosis is a rare and benign endoscopic finding with distinct macroscopic and histological characteristics. <b>Case series:</b> We observed a form of unprecedented colitis in eight patients in a 3-month period. Operators have found, during colonoscopy, flat or slightly raised whitish-yellow plaques, in the colonic mucosa of all patients. Histological examination concluded to pseudolipomatosis. After investigation, the disinfectant machine was found to have technical malfunctioning of the rinse cycle of the endoscope during this period. No other cases were observed after the machine was fixed. <b>Conclusion:</b> Pseudolipomatosis is more an endoscopically induced lesion than a true pathological condition. A careful check of the disinfection process should be carried out when such lesions are detected.</p>","PeriodicalId":12568,"journal":{"name":"Future Science OA","volume":"10 1","pages":"FSO985"},"PeriodicalIF":2.5,"publicationDate":"2024-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11172253/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141310455","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Ferric carboxymaltose for iron deficiency in patients with heart failure: a systematic review and meta-analysis. 羧甲基铁治疗心力衰竭患者的铁缺乏症：系统综述和荟萃分析。
IF 2.4
Future Science OA Pub Date : 2024-12-31 Epub Date: 2024-07-09 DOI: 10.1080/20565623.2024.2367956
Burhanuddin Sohail Rangwala, Varisha Zuhair, Muhammad Saqlain Mustafa, Abdullah Mussarat, Aimen Waqar Khan, Fnu Danish, Syeda Mahrukh Fatima Zaidi, Faizan Ur Rehman, Muhammad Ashir Shafique
{"title":"Ferric carboxymaltose for iron deficiency in patients with heart failure: a systematic review and meta-analysis.","authors":"Burhanuddin Sohail Rangwala, Varisha Zuhair, Muhammad Saqlain Mustafa, Abdullah Mussarat, Aimen Waqar Khan, Fnu Danish, Syeda Mahrukh Fatima Zaidi, Faizan Ur Rehman, Muhammad Ashir Shafique","doi":"10.1080/20565623.2024.2367956","DOIUrl":"10.1080/20565623.2024.2367956","url":null,"abstract":"<p><p><b>Aim:</b> Iron deficiency (ID) is associated with heart failure (HF) in a considerable proportion of patients. To improve the quality of life, lower the frequency of hospitalizations, and lower mortality rates of chronic HF patients (HF), this meta-analysis will look into the role of iron supplementation using ferric carboxymaltose (FCM). <b>Methods & results:</b> From inception until 1 October 2023, we conducted a thorough literature search of electronic databases for peer-reviewed publications. Around 5229 HF patients were included, of which 2691 received FCM while 2538 received placebo. <b>Conclusion:</b> FCM reduces HF-related hospitalizations but doesn't improve overall or cardiovascular mortality in those with HF and ID. The overall results support FCM's role in managing iron deficiency in heart failure.</p>","PeriodicalId":12568,"journal":{"name":"Future Science OA","volume":"10 1","pages":"2367956"},"PeriodicalIF":2.4,"publicationDate":"2024-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11238921/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141563145","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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