Future Science OA最新文献

Previous immunological disease can promote neurological complications of SARS-CoV-2 infection, such as VST or GBS. 既往免疫性疾病可促进SARS-CoV-2感染的神经系统并发症，如VST或GBS。

IF 2.4

Future Science OA Pub Date : 2025-12-01 Epub Date: 2025-02-10 DOI: 10.1080/20565623.2025.2463849

Josef Finsterer

引用次数: 0

Adverse predictive value of ASPM on lung adenocarcinoma overall survival depended on chemotherapy status. ASPM对肺腺癌总生存的不良预测价值依赖于化疗状态。

IF 2.4

Future Science OA Pub Date : 2025-12-01 Epub Date: 2025-04-09 DOI: 10.1080/20565623.2025.2489328

Yan Zheng, Baichen Sun, Zhiling Qu

{"title":"Adverse predictive value of ASPM on lung adenocarcinoma overall survival depended on chemotherapy status.","authors":"Yan Zheng, Baichen Sun, Zhiling Qu","doi":"10.1080/20565623.2025.2489328","DOIUrl":"https://doi.org/10.1080/20565623.2025.2489328","url":null,"abstract":"Objective: Transcriptome and proteome analyses may yield inconsistent predictions regarding tumor prognosis. The clinical and pathological significance of ASPM expression in lung adenocarcinoma (LUAD) remains unclear. This study investigates the expression and prognostic value of ASPM, focusing on its role in chemotherapy outcomes.Methods: We analyzed the prognostic relevance of ASPM using bioinformatics, immunohistochemical staining of LUAD tissue microarrays, and proteomics data. Further, in vitro experiments were conducted to evaluate the effects of ASPM overexpression on cell proliferation and sensitivity to cisplatin.Results: Bioinformatics analysis revealed that ASPM's prognostic significance differed between transcriptomic and proteomic datasets. Immunohistochemistry showed that high ASPM expression predicted improved overall survival only in LUAD patients undergoing chemotherapy, not in those without. Proteomics analysis identified ASPM-related signatures enriched in cell cycle and mitosis pathways. In vitro, ASPM overexpression promoted tumor cell proliferation and enhanced cisplatin-induced cytotoxicity.Conclusion: ASPM exhibits a dual role in LUAD prognosis, acting as a marker for improved chemotherapy outcomes while promoting tumor proliferation. These findings underscore ASPM's potential as a therapeutic target and predictive marker for personalized treatment in LUAD.","PeriodicalId":12568,"journal":{"name":"Future Science OA","volume":"11 1","pages":"2489328"},"PeriodicalIF":2.4,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143811072","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Resveratrol alleviates depressive-like behavior via the activation of SIRT1/NF-κB signaling pathway in microglia. 白藜芦醇通过激活小胶质细胞中SIRT1/NF-κB信号通路减轻抑郁样行为。

IF 2.4

Future Science OA Pub Date : 2025-12-01 Epub Date: 2025-02-18 DOI: 10.1080/20565623.2025.2463852

Yuehong Wu, Yixia Zhu, Shun Zheng, Ding Mingxing

{"title":"Resveratrol alleviates depressive-like behavior via the activation of SIRT1/NF-κB signaling pathway in microglia.","authors":"Yuehong Wu, Yixia Zhu, Shun Zheng, Ding Mingxing","doi":"10.1080/20565623.2025.2463852","DOIUrl":"10.1080/20565623.2025.2463852","url":null,"abstract":"Background: Currently, the pathogenesis of depression remains poorly understood, leading to many patients receiving ineffective treatment. Resveratrol has demonstrated beneficial effects in the prevention and treatment of depression. However, it remains unknown whether resveratrol administration can counteract depression-like behaviors by regulating the SIRT1/NF-κB signaling pathway.Methodology/principal findings: Male C57BL/6 mice were randomly assigned to a control group, a depression group, and a resveratrol group. The depression model was established using chronic unpredictable mild stress (CUMS) for 5 weeks. Behavioral tests were conducted to assess depressive-like behaviors. The expression levels of SIRT1 and NF-κB in the hippocampus of mice and BV2 microglial cells were measured. After 5 weeks of modeling, the results indicated that mice in the depression group exhibited significant depressive-like behaviors and inhibited activation of the SIRT1/NF-κB signaling pathway. In contrast, resveratrol administration effectively reversed these changes. Results from in vitro experiments showed that LPS stimulation increased microglial activity and downregulated the SIRT1/NF-κB signaling pathway in microglia; however, resveratrol treatment mitigated these effects.Conclusions/significance: Our findings suggested that resveratrol can alleviate CUMS-induced depression-like behaviors via the activation of the Sirt1/NF-κB pathway in microglia.","PeriodicalId":12568,"journal":{"name":"Future Science OA","volume":"11 1","pages":"2463852"},"PeriodicalIF":2.4,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11845112/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143448864","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Tracking protein kinase targeting advances: integrating QSAR into machine learning for kinase-targeted drug discovery. 跟踪蛋白激酶靶向进展：将QSAR整合到机器学习中用于激酶靶向药物发现。

IF 2.4

Future Science OA Pub Date : 2025-12-01 Epub Date: 2025-04-04 DOI: 10.1080/20565623.2025.2483631

Rand Shahin, Sawsan Jaafreh, Yusra Azzam

{"title":"Tracking protein kinase targeting advances: integrating QSAR into machine learning for kinase-targeted drug discovery.","authors":"Rand Shahin, Sawsan Jaafreh, Yusra Azzam","doi":"10.1080/20565623.2025.2483631","DOIUrl":"https://doi.org/10.1080/20565623.2025.2483631","url":null,"abstract":"Protein kinases are vital drug targets, yet designing selective inhibitors is challenging, compounded by resistance and kinome complexity. This review explores Quantitative Structure-Activity Relationship (QSAR) modeling for kinase drug discovery, focusing on integrating traditional QSAR with machine learning (ML)-CNNs, RNNs-and structural data. Methods include structural databases, docking, and deep learning QSAR. Key findings show ML-integrated QSAR significantly improves selective inhibitor design for CDKs, JAKs, PIM kinases. The IDG-DREAM challenge exemplifies ML's potential for accurate kinase-inhibitor interaction prediction, outperforming traditional methods and enabling inhibitors with enhanced selectivity, efficacy, and resistance mitigation. QSAR combined with advanced computation and experimental data accelerates kinase drug discovery, offering transformative precision medicine potential. This review highlights deep learning-enhanced QSAR's novelty in automating feature extraction and capturing complex relationships, surpassing traditional QSAR, while emphasizing interpretability and experimental validation for clinical translation.","PeriodicalId":12568,"journal":{"name":"Future Science OA","volume":"11 1","pages":"2483631"},"PeriodicalIF":2.4,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143779417","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Mechanistic approach and therapeutic strategies in menstrual and non-menstrual migraine. 经期和非经期偏头痛的机制方法和治疗策略。

IF 2.4

Future Science OA Pub Date : 2025-12-01 Epub Date: 2025-03-04 DOI: 10.1080/20565623.2025.2468109

Tanya Mani, Munira Murtaza, Rukaiah Fatma Begum, H Gayathri, M Sumithra

引用次数: 0

TWEAK/Fn14 axis may promote vascular smooth muscle cell senescence via p38 signaling pathway: preliminary evidence. TWEAK/Fn14轴可能通过p38信号通路促进血管平滑肌细胞衰老：初步证据

IF 2.4

Future Science OA Pub Date : 2025-12-01 Epub Date: 2025-01-22 DOI: 10.1080/20565623.2025.2455906

Chunyang Wei, Xiaoying Liu, Zhuang Miao, Hua Zhang, Yanfu Wang, Guoxian Qi

引用次数: 0

A study to determine the effect of nano-selenium and thymoquinone on the Nrf2 gene expression in Alzheimer's disease. 纳米硒和百里醌对阿尔茨海默病Nrf2基因表达影响的研究。

IF 2.4

Future Science OA Pub Date : 2025-12-01 Epub Date: 2025-01-31 DOI: 10.1080/20565623.2025.2458434

Doha El-Sayed Ellakwa, Laila Ahmed Rashed, Ola Sayed Ali, Noha Amr El-Sabbagh

{"title":"A study to determine the effect of nano-selenium and thymoquinone on the Nrf2 gene expression in Alzheimer's disease.","authors":"Doha El-Sayed Ellakwa, Laila Ahmed Rashed, Ola Sayed Ali, Noha Amr El-Sabbagh","doi":"10.1080/20565623.2025.2458434","DOIUrl":"10.1080/20565623.2025.2458434","url":null,"abstract":"Introduction: Alzheimer's disease is a developing public health concern in aging communities that affects a sizable section of the global population. The risk of Alzheimer's disease increases with age; it affects one-third of males and two-thirds of women. This research attempts to assess the effect of nano-selenium and thymoquinone on Nrf2 gene expression levels in Alzheimer's disease (AD).Methods: There were five identical groups of 50 albino male rats: a control group that was healthy; an AD positive control group; an AD group that received nano-selenium (5 mg/kg); an AD group that received thymoquinone (2 mg/kg); and an AD group that received both. The duration of treatment was 4 weeks. The levels of Nrf2 in brain tissues were evaluated using real-time PCR.Results: Nrf2 mean expression levels in the nano-selenium-treated rats, the thymoquinone-treated rats, and the rats that were given both treatments all increased significantly compared to AD rats with no treatment.Conclusions: This study showed that nano-selenium and thymoquinone elevated Nrf2 gene expression levels in AD.","PeriodicalId":12568,"journal":{"name":"Future Science OA","volume":"11 1","pages":"2458434"},"PeriodicalIF":2.4,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11792829/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143064779","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Reporting and representation of participant race and ethnicity in phase III clinical trials for solid tumors. 实体瘤III期临床试验中参与者种族和民族的报告和代表性。

IF 2.4

Future Science OA Pub Date : 2025-12-01 Epub Date: 2025-01-30 DOI: 10.1080/20565623.2025.2458415

Tianyi Wang, Dinorah J Villanueva, Ambily Banerjee, Dina Gifkins

{"title":"Reporting and representation of participant race and ethnicity in phase III clinical trials for solid tumors.","authors":"Tianyi Wang, Dinorah J Villanueva, Ambily Banerjee, Dina Gifkins","doi":"10.1080/20565623.2025.2458415","DOIUrl":"10.1080/20565623.2025.2458415","url":null,"abstract":"Background: Including racial and ethnic minorities in clinical trials is essential for advancing health equity. Despite progress, trials often do not mirror patient population demographics.Methods: The National Library of Medicine's Clinical Trials database was queried for phase III trials of lung, colorectal, breast, and prostate cancers. A reference population was identified from the Surveillance, Epidemiology, and End Result (SEER) database, covering 48% of the US population.Results: Among 181 trials, race and ethnicity data were included in 86.7% and 60.2% of trials, respectively, with improving reporting over time. Participants were predominantly White (76.3%), followed by Asian/Pacific Islander (14.1%), Black/African American (4.5%), and American Indian/Alaska Native (0.6%). Hispanic/Latino constituted 6.4% of participants. The proportion of non-White groups increased from 19.4% in trials started before 2011 to 26.2% after 2015. Compared with SEER data, the percentages were lower for Asian/Pacific Islander across all cancers, Black/African American in breast and prostate cancers, American Indian or Alaska Native in colorectal, breast, and prostate cancers in US solely trials.Conclusions: Reporting and enrollment of racial and ethnic minorities in trials remain inadequate but improving. To enhance diversity, real-world data are warranted to identify recruitment goals by better assessing the geographic distribution within the patient population.","PeriodicalId":12568,"journal":{"name":"Future Science OA","volume":"11 1","pages":"2458415"},"PeriodicalIF":2.4,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11792851/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143064963","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Quantum leadership: new approach in managing shoulder dystocia in simulation-based training. 量子领导力：模拟训练中处理肩难产的新方法。

IF 2.4

Future Science OA Pub Date : 2025-12-01 Epub Date: 2025-01-30 DOI: 10.1080/20565623.2025.2458427

Georges Yared, Christopher Massaad, Kariman Ghazal

{"title":"Quantum leadership: new approach in managing shoulder dystocia in simulation-based training.","authors":"Georges Yared, Christopher Massaad, Kariman Ghazal","doi":"10.1080/20565623.2025.2458427","DOIUrl":"10.1080/20565623.2025.2458427","url":null,"abstract":"Background: Shoulder dystocia, a challenging condition for obstetricians, poses significant risks to both maternal and neonatal health, including maternal postpartum hemorrhage, neonatal hypoxia, and brachial plexus injury. Despite being unpredictable and unpreventable, effective management can mitigate these risks. Miscommunication and poor leadership are responsible for 72% of medical errors, which further highlights the importance of robust leadership skills in obstetric emergencies.Research design and methods: A qualitative study involving 20 participants through structured interviews assessed preferred leadership styles in managing shoulder dystocia.Results: Findings revealed that 55% of participants favored quantum leadership. Other preferences included laissez-faire by one anesthesiologist and democratic by two midwives. However, all participants acknowledged the efficacy of the seven quantum leadership skills in managing shoulder dystocia. Discussion emphasized that traditional leadership styles are less effective compared to quantum leadership in managing the complexities of shoulder dystocia. The quantum Ob-Wheel, consisting of 12 milestones, integrates these seven interdependent skills to guide the management process.Conclusions: Despite the limited sample size of this study, it is worth noting that, given the unpredictable nature of shoulder dystocia, clinicians should be prepared for its occurrence during any birth, with quantum leadership providing a strategic advantage in such scenarios.","PeriodicalId":12568,"journal":{"name":"Future Science OA","volume":"11 1","pages":"2458427"},"PeriodicalIF":2.4,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11792848/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143064987","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Elevated expression of ANAPC1 in lung squamous cell carcinoma: clinical implications and mechanisms. ANAPC1在肺鳞状细胞癌中的表达升高：临床意义和机制

IF 2.4

Future Science OA Pub Date : 2025-12-01 Epub Date: 2025-03-26 DOI: 10.1080/20565623.2025.2482487

Xiao-Song Chen, Feng Chen, Shu-Jia He, Yi-Yang Chen, Bang-Teng Chi, Wan-Ying Huang, Yue Wei, Chun-Yan Zhao, Chang Song, Rong-Quan He, Gang Chen, Jin-Liang Kong, Hui-Ping Lu

{"title":"Elevated expression of ANAPC1 in lung squamous cell carcinoma: clinical implications and mechanisms.","authors":"Xiao-Song Chen, Feng Chen, Shu-Jia He, Yi-Yang Chen, Bang-Teng Chi, Wan-Ying Huang, Yue Wei, Chun-Yan Zhao, Chang Song, Rong-Quan He, Gang Chen, Jin-Liang Kong, Hui-Ping Lu","doi":"10.1080/20565623.2025.2482487","DOIUrl":"10.1080/20565623.2025.2482487","url":null,"abstract":"Aim: To investigate the comprehensive expression levels and possible molecular mechanisms of Anaphase Promoting Complex Subunit 1 (ANAPC1) in lung squamous cell carcinoma (LUSC).Methods: Data from 2,031 samples were combined to evaluate ANAPC1 mRNA levels, and 118 samples were collected for immunohistochemical (IHC) analysis. High-expression co-expressed genes (HECEGs) associated with ANAPC1 were analyzed for signaling pathways. Clinical significance, immune computations, and Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR) validation of ANAPC1's role in LUSC were assessed. Molecular docking evaluated binding affinity with potential therapeutics.Results: ANAPC1 mRNA was significantly upregulated in LUSC (SMD = 1.97, 95% CI [1.26-2.67]). Protein-level analysis confirmed this upregulation (p < 0.001). Most HECEGs associated with ANAPC1 were enriched in cell cycle pathways. Higher ANAPC1 expression correlated with poorer survival in LUSC patients (HR = 1.11, 95% CI: 1-1.49). ANAPC1 expression was higher in males and N1-stage vs. females and N0-stage; lower in grade I vs. II/III. Overexpression reduces immune cell infiltration and immunotherapy effectiveness, while knockdown inhibits cell proliferation. Drug sensitivity and docking analyses identified tenovin-1, carboxyatractyloside, and phycocyanobilin as potential antitumor agents targeting ANAPC1.Conclusion: The elevated expression of ANAPC1 might play a role in LUSC advancement and progression through its participation in cell growth-related pathways.","PeriodicalId":12568,"journal":{"name":"Future Science OA","volume":"11 1","pages":"2482487"},"PeriodicalIF":2.4,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11951694/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143729534","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0