Future Science OA最新文献

Previous immunological disease can promote neurological complications of SARS-CoV-2 infection, such as VST or GBS.

IF 2.4

Future Science OA Pub Date : 2025-12-01 Epub Date: 2025-02-10 DOI: 10.1080/20565623.2025.2463849

Josef Finsterer

引用次数: 0

Resveratrol alleviates depressive-like behavior via the activation of SIRT1/NF-κB signaling pathway in microglia.

IF 2.4

Future Science OA Pub Date : 2025-12-01 Epub Date: 2025-02-18 DOI: 10.1080/20565623.2025.2463852

Yuehong Wu, Yixia Zhu, Shun Zheng, Ding Mingxing

{"title":"Resveratrol alleviates depressive-like behavior via the activation of SIRT1/NF-κB signaling pathway in microglia.","authors":"Yuehong Wu, Yixia Zhu, Shun Zheng, Ding Mingxing","doi":"10.1080/20565623.2025.2463852","DOIUrl":"10.1080/20565623.2025.2463852","url":null,"abstract":"Background: Currently, the pathogenesis of depression remains poorly understood, leading to many patients receiving ineffective treatment. Resveratrol has demonstrated beneficial effects in the prevention and treatment of depression. However, it remains unknown whether resveratrol administration can counteract depression-like behaviors by regulating the SIRT1/NF-κB signaling pathway.Methodology/principal findings: Male C57BL/6 mice were randomly assigned to a control group, a depression group, and a resveratrol group. The depression model was established using chronic unpredictable mild stress (CUMS) for 5 weeks. Behavioral tests were conducted to assess depressive-like behaviors. The expression levels of SIRT1 and NF-κB in the hippocampus of mice and BV2 microglial cells were measured. After 5 weeks of modeling, the results indicated that mice in the depression group exhibited significant depressive-like behaviors and inhibited activation of the SIRT1/NF-κB signaling pathway. In contrast, resveratrol administration effectively reversed these changes. Results from in vitro experiments showed that LPS stimulation increased microglial activity and downregulated the SIRT1/NF-κB signaling pathway in microglia; however, resveratrol treatment mitigated these effects.Conclusions/significance: Our findings suggested that resveratrol can alleviate CUMS-induced depression-like behaviors via the activation of the Sirt1/NF-κB pathway in microglia.","PeriodicalId":12568,"journal":{"name":"Future Science OA","volume":"11 1","pages":"2463852"},"PeriodicalIF":2.4,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11845112/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143448864","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Mechanistic approach and therapeutic strategies in menstrual and non-menstrual migraine.

IF 2.4

Future Science OA Pub Date : 2025-12-01 Epub Date: 2025-03-04 DOI: 10.1080/20565623.2025.2468109

Tanya Mani, Munira Murtaza, Rukaiah Fatma Begum, H Gayathri, M Sumithra

引用次数: 0

TWEAK/Fn14 axis may promote vascular smooth muscle cell senescence via p38 signaling pathway: preliminary evidence. TWEAK/Fn14轴可能通过p38信号通路促进血管平滑肌细胞衰老：初步证据

IF 2.4

Future Science OA Pub Date : 2025-12-01 Epub Date: 2025-01-22 DOI: 10.1080/20565623.2025.2455906

Chunyang Wei, Xiaoying Liu, Zhuang Miao, Hua Zhang, Yanfu Wang, Guoxian Qi

引用次数: 0

A study to determine the effect of nano-selenium and thymoquinone on the Nrf2 gene expression in Alzheimer's disease.

IF 2.4

Future Science OA Pub Date : 2025-12-01 Epub Date: 2025-01-31 DOI: 10.1080/20565623.2025.2458434

Doha El-Sayed Ellakwa, Laila Ahmed Rashed, Ola Sayed Ali, Noha Amr El-Sabbagh

{"title":"A study to determine the effect of nano-selenium and thymoquinone on the Nrf2 gene expression in Alzheimer's disease.","authors":"Doha El-Sayed Ellakwa, Laila Ahmed Rashed, Ola Sayed Ali, Noha Amr El-Sabbagh","doi":"10.1080/20565623.2025.2458434","DOIUrl":"10.1080/20565623.2025.2458434","url":null,"abstract":"Introduction: Alzheimer's disease is a developing public health concern in aging communities that affects a sizable section of the global population. The risk of Alzheimer's disease increases with age; it affects one-third of males and two-thirds of women. This research attempts to assess the effect of nano-selenium and thymoquinone on Nrf2 gene expression levels in Alzheimer's disease (AD).Methods: There were five identical groups of 50 albino male rats: a control group that was healthy; an AD positive control group; an AD group that received nano-selenium (5 mg/kg); an AD group that received thymoquinone (2 mg/kg); and an AD group that received both. The duration of treatment was 4 weeks. The levels of Nrf2 in brain tissues were evaluated using real-time PCR.Results: Nrf2 mean expression levels in the nano-selenium-treated rats, the thymoquinone-treated rats, and the rats that were given both treatments all increased significantly compared to AD rats with no treatment.Conclusions: This study showed that nano-selenium and thymoquinone elevated Nrf2 gene expression levels in AD.","PeriodicalId":12568,"journal":{"name":"Future Science OA","volume":"11 1","pages":"2458434"},"PeriodicalIF":2.4,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11792829/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143064779","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Reporting and representation of participant race and ethnicity in phase III clinical trials for solid tumors.

IF 2.4

Future Science OA Pub Date : 2025-12-01 Epub Date: 2025-01-30 DOI: 10.1080/20565623.2025.2458415

Tianyi Wang, Dinorah J Villanueva, Ambily Banerjee, Dina Gifkins

{"title":"Reporting and representation of participant race and ethnicity in phase III clinical trials for solid tumors.","authors":"Tianyi Wang, Dinorah J Villanueva, Ambily Banerjee, Dina Gifkins","doi":"10.1080/20565623.2025.2458415","DOIUrl":"10.1080/20565623.2025.2458415","url":null,"abstract":"Background: Including racial and ethnic minorities in clinical trials is essential for advancing health equity. Despite progress, trials often do not mirror patient population demographics.Methods: The National Library of Medicine's Clinical Trials database was queried for phase III trials of lung, colorectal, breast, and prostate cancers. A reference population was identified from the Surveillance, Epidemiology, and End Result (SEER) database, covering 48% of the US population.Results: Among 181 trials, race and ethnicity data were included in 86.7% and 60.2% of trials, respectively, with improving reporting over time. Participants were predominantly White (76.3%), followed by Asian/Pacific Islander (14.1%), Black/African American (4.5%), and American Indian/Alaska Native (0.6%). Hispanic/Latino constituted 6.4% of participants. The proportion of non-White groups increased from 19.4% in trials started before 2011 to 26.2% after 2015. Compared with SEER data, the percentages were lower for Asian/Pacific Islander across all cancers, Black/African American in breast and prostate cancers, American Indian or Alaska Native in colorectal, breast, and prostate cancers in US solely trials.Conclusions: Reporting and enrollment of racial and ethnic minorities in trials remain inadequate but improving. To enhance diversity, real-world data are warranted to identify recruitment goals by better assessing the geographic distribution within the patient population.","PeriodicalId":12568,"journal":{"name":"Future Science OA","volume":"11 1","pages":"2458415"},"PeriodicalIF":2.4,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11792851/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143064963","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Quantum leadership: new approach in managing shoulder dystocia in simulation-based training.

IF 2.4

Future Science OA Pub Date : 2025-12-01 Epub Date: 2025-01-30 DOI: 10.1080/20565623.2025.2458427

Georges Yared, Christopher Massaad, Kariman Ghazal

{"title":"Quantum leadership: new approach in managing shoulder dystocia in simulation-based training.","authors":"Georges Yared, Christopher Massaad, Kariman Ghazal","doi":"10.1080/20565623.2025.2458427","DOIUrl":"10.1080/20565623.2025.2458427","url":null,"abstract":"Background: Shoulder dystocia, a challenging condition for obstetricians, poses significant risks to both maternal and neonatal health, including maternal postpartum hemorrhage, neonatal hypoxia, and brachial plexus injury. Despite being unpredictable and unpreventable, effective management can mitigate these risks. Miscommunication and poor leadership are responsible for 72% of medical errors, which further highlights the importance of robust leadership skills in obstetric emergencies.Research design and methods: A qualitative study involving 20 participants through structured interviews assessed preferred leadership styles in managing shoulder dystocia.Results: Findings revealed that 55% of participants favored quantum leadership. Other preferences included laissez-faire by one anesthesiologist and democratic by two midwives. However, all participants acknowledged the efficacy of the seven quantum leadership skills in managing shoulder dystocia. Discussion emphasized that traditional leadership styles are less effective compared to quantum leadership in managing the complexities of shoulder dystocia. The quantum Ob-Wheel, consisting of 12 milestones, integrates these seven interdependent skills to guide the management process.Conclusions: Despite the limited sample size of this study, it is worth noting that, given the unpredictable nature of shoulder dystocia, clinicians should be prepared for its occurrence during any birth, with quantum leadership providing a strategic advantage in such scenarios.","PeriodicalId":12568,"journal":{"name":"Future Science OA","volume":"11 1","pages":"2458427"},"PeriodicalIF":2.4,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11792848/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143064987","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Reply to the letter to the editor: previous immunological disease can promote neurological complications of SARS-CoV-2 infection, such as VST or GBS.

IF 2.4

Future Science OA Pub Date : 2025-12-01 Epub Date: 2025-02-17 DOI: 10.1080/20565623.2025.2463851

Shema Ayadi, Hela Jamoussi

引用次数: 0

The association between whole blood viscosity and CHA2DS2-VASc/CHA2DS2-VA scores in patients with atrial fibrillation.

IF 2.4

Future Science OA Pub Date : 2025-12-01 Epub Date: 2025-02-18 DOI: 10.1080/20565623.2025.2467607

Erkan Kahraman, Koray Kalenderoglu

{"title":"The association between whole blood viscosity and CHA2DS2-VASc/CHA2DS2-VA scores in patients with atrial fibrillation.","authors":"Erkan Kahraman, Koray Kalenderoglu","doi":"10.1080/20565623.2025.2467607","DOIUrl":"10.1080/20565623.2025.2467607","url":null,"abstract":"Introduction: CHA2DS2-VASc and CHA2DS2-VA scores are often used to demonstrate thromboembolic risk in nonvalvular atrial fibrillation. Elevated whole blood viscosity is an independent risk factor for ischemic stroke.Objective: This study aimed to ascertain the correlation between whole blood viscosity and CHA2DS2-VASc/CHA2DS2-VA scores.Methods: This study was performed retrospectively in a tertiary cardiac facility, encompassing 150 patients.Results: The study's results demonstrate that whole blood viscosity, concerning both high shear rate and low shear rate variables, are statistically significant in forecasting the likelihood of elevated CHA2DS2-VA and CHA2DS2-VASc scores. (AUC: 0.690, 0.693; p: <0.001; 0.647, 0.665; p: <0.05).Conclusion: Whole blood viscosity had a substantial correlation with the CHA2DS2-VASc/CHA2DS2-VA scores in patients with atrial fibrillation and may be used to evaluate thromboembolism risk, akin to these scores.","PeriodicalId":12568,"journal":{"name":"Future Science OA","volume":"11 1","pages":"2467607"},"PeriodicalIF":2.4,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11845118/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143448798","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Modifiable risk factors of dementia in the Indian scenario.

IF 2.4

Future Science OA Pub Date : 2025-12-01 Epub Date: 2025-03-24 DOI: 10.1080/20565623.2025.2483132

Ankul Singh S, Lakshmi Chandran, Chitra Vellapandian

引用次数: 0