Future Science OA最新文献

Understanding breast cancer causes: insights from Jordanian women's awareness. 了解乳腺癌的原因：来自约旦妇女意识的见解。

IF 2.1

Future Science OA Pub Date : 2026-12-01 Epub Date: 2026-02-09 DOI: 10.1080/20565623.2026.2626432

Ghaith B Heilat, Tahani Alwidyan, Amjad Z Alrosan, Aseel O Rataan, Khaled Alrosan, Zuheir R Al Rousan

{"title":"Understanding breast cancer causes: insights from Jordanian women's awareness.","authors":"Ghaith B Heilat, Tahani Alwidyan, Amjad Z Alrosan, Aseel O Rataan, Khaled Alrosan, Zuheir R Al Rousan","doi":"10.1080/20565623.2026.2626432","DOIUrl":"10.1080/20565623.2026.2626432","url":null,"abstract":"Objective: To evaluate the awareness and understanding of breast cancer (BC) etiology among Jordanian women and identify associated demographic factors.Materials and methods: A multiregional cross-sectional survey of 381 women was conducted via online snowball sampling. BC knowledge was assessed using a translated version of the Breast Cancer Awareness Measure. Statistical analyses included univariate and bivariate tests, followed by a multivariate ordinal logistic regression to adjust for potential confounders.Results: Only 39.9% of participants demonstrated proficient comprehension of BC etiology. Knowledge correlated significantly with age, marital status, and expertise (p < 0.05). Awareness was highest among single pharmacy students; notably, 64.8% were single pharmacy students, potentially inflating overall scores. A misconception was identified: 66.1% believed a diagnosis in one breast reduces risk in the other. Age 41-50 (OR = 5.23) and holding a diploma (OR = 0.09) were significant predictors of knowledge compared to postgraduates, while marital status was not significant in the model.Conclusions: Educational backgrounds significantly influence breast cancer awareness among Jordanian women. There is an urgent need for targeted, community-based training programs to address persistent clinical misconceptions and knowledge gaps, specifically focusing on married women and individuals working or studying in non-medical fields, to improve overall public health standards nationwide.","PeriodicalId":12568,"journal":{"name":"Future Science OA","volume":"12 1","pages":"2626432"},"PeriodicalIF":2.1,"publicationDate":"2026-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12893684/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146141958","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Ketamine as primary anesthetic for upper limb trauma during war: a case series of 100 surgeries at Rafik Hariri University Hospital, Lebanon's National War Trauma Referral Center. 氯胺酮作为战争期间上肢创伤的主要麻醉剂：拉菲克·哈里里大学医院、黎巴嫩国家战争创伤转诊中心的100例手术病例系列。

IF 2.1

Future Science OA Pub Date : 2026-12-01 Epub Date: 2026-02-04 DOI: 10.1080/20565623.2026.2622334

Mustapha Nahle, Miguel Nunez, Mayyas Msheik

{"title":"Ketamine as primary anesthetic for upper limb trauma during war: a case series of 100 surgeries at Rafik Hariri University Hospital, Lebanon's National War Trauma Referral Center.","authors":"Mustapha Nahle, Miguel Nunez, Mayyas Msheik","doi":"10.1080/20565623.2026.2622334","DOIUrl":"10.1080/20565623.2026.2622334","url":null,"abstract":"Background: The Beirut pager explosions on September 17, 2024 resulted in mass casualties with severe upper limb trauma admitted to Rafik Hariri University Hospital (RHUH), Lebanon's national war trauma referral center. Initial opioid-based anesthesia was associated with postoperative respiratory complications and high opioid requirements. Ketamine became available the following day through the International Committee of the Red Cross (ICRC). This study evaluates the transition to ketamine as a primary anesthetic and its effects on pain control, hemodynamics, respiration, and opioid use.Methods: We retrospectively reviewed 100 hand and finger amputation surgeries. Patients initially received fentanyl intraoperatively and opioids postoperatively. Ketamine was subsequently introduced as the primary anesthetic. Pain was assessed using the Visual Analog Scale (VAS), while respiratory and hemodynamic parameters were monitored perioperatively.Results: Ketamine was associated with significantly lower VAS scores (3.2 vs 7.8; p < 0.001), no respiratory complications (0 vs 18 cases), stable mean arterial pressure in 94% of patients, and reduced postoperative opioid use (5% vs 65%).Conclusion: Ketamine is a safe, effective, opioid-sparing anesthetic and should be prioritized in conflict and resource-limited trauma settings.","PeriodicalId":12568,"journal":{"name":"Future Science OA","volume":"12 1","pages":"2622334"},"PeriodicalIF":2.1,"publicationDate":"2026-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12885423/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146112829","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Body shape concerns among Jordanian university students: prevalence, correlates, and association with social media use. 约旦大学生对体型的关注：流行程度、相关性以及与社交媒体使用的关系

IF 2.1

Future Science OA Pub Date : 2026-12-01 Epub Date: 2025-12-12 DOI: 10.1080/20565623.2025.2601632

Hadeel Heilat, Shuja Mashagba, Mosab Said, Ronza Nemrawi, Fadi Alkhawaja, Eman Al-Refai, Mohammad AlElaimat, Saleh Bani Nassr, Dima Oudat

{"title":"Body shape concerns among Jordanian university students: prevalence, correlates, and association with social media use.","authors":"Hadeel Heilat, Shuja Mashagba, Mosab Said, Ronza Nemrawi, Fadi Alkhawaja, Eman Al-Refai, Mohammad AlElaimat, Saleh Bani Nassr, Dima Oudat","doi":"10.1080/20565623.2025.2601632","DOIUrl":"10.1080/20565623.2025.2601632","url":null,"abstract":"Background: Body shape concerns (BSC) and body dissatisfaction represent emerging public health issues, yet evidence from Middle Eastern contexts, including Jordan, remains limited. These concerns adversely affect psychological health and are shaped by sociocultural pressures and digital media exposure.Methods: A cross-sectional study was conducted among 418 undergraduate university students in Northern Jordan. Participants completed the Body Shape Questionnaire-8D (BSQ-8D) to assess BSC. Demographic, behavioral, and media use variables were analyzed to identify correlations.Results: Among 418 respondents (96% aged 17-24; 53% female), 73% reported no BSC. Higher levels of BSC were significantly associated with increased body mass index (BMI) (p < 0.001). Compared to normal-weight peers, overweight students had higher odds of reporting mild [adjusted odds ratio (AOR: 3.7)]and moderate to marked (AOR: 2.56) BSC. Parental education and social media use were also significant factors. Students who did not use Snapchat (AOR = 2.05), did not use TikTok (AOR = 2.15), and cigarette smokers (AOR = 2.75) had higher odds of reporting elevated BSC levels.Conclusions: BSC among Jordanian university students is shaped by multiple psychosocial and behavioral factors, with BMI emerging as the strongest predictor. Findings underscore the need for culturally informed strategies addressing weight stigma, smoking, parental influences, and media engagement. Integrating BSC screening into routine healthcare may support early detection of at-risk groups.","PeriodicalId":12568,"journal":{"name":"Future Science OA","volume":"12 1","pages":"2601632"},"PeriodicalIF":2.1,"publicationDate":"2026-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12710888/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145741976","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Novel male contraceptives. 新型男性避孕药。

IF 2.5

Future Science OA Pub Date : 2026-12-01 Epub Date: 2026-04-29 DOI: 10.1080/20565623.2026.2664612

Jacqueline Quinn, John J Reynolds-Wright

引用次数: 0

Non-immune hydrops fetalis (NIHF): diagnostic evaluation and lessons learned from a case series. 非免疫性水肿胎儿（NIHF）：诊断评价和从一系列病例中吸取的教训。

IF 2.5

Future Science OA Pub Date : 2026-12-01 Epub Date: 2026-06-03 DOI: 10.1080/20565623.2026.2681420

Jihad Al Hassan, Georges Yared, Charlotte El Hajjar, Manal Dahrouj, Christopher Massaad, Ahmad El Moghrabi, Kariman Ghazal

{"title":"Non-immune hydrops fetalis (NIHF): diagnostic evaluation and lessons learned from a case series.","authors":"Jihad Al Hassan, Georges Yared, Charlotte El Hajjar, Manal Dahrouj, Christopher Massaad, Ahmad El Moghrabi, Kariman Ghazal","doi":"10.1080/20565623.2026.2681420","DOIUrl":"10.1080/20565623.2026.2681420","url":null,"abstract":"Background: Fetal hydrops, characterized by abnormal fluid accumulation in two or more fetal compartments, is a critical condition with a poor prognosis, often resulting in significant fetal mortality. The condition itself is not a diagnosis but a clinical sign with many underlying causes, ranging from infections and chromosomal abnormalities to rare maternal conditions such as mirror syndrome.Case presentation: This review examines three cases of fetal hydrops, highlighting common etiologies, such as infections and chromosomal disorders, and more unusual causes like maternal complications.Diagnostic approach: The current approach to diagnosing hydrops fetalis relies primarily on ultrasound imaging and Doppler studies to identify abnormal fluid accumulation and pathophysiology.Future perspective: However, advances in genomic testing are rapidly transforming the diagnostic pathway. With increasing accuracy, speed and accessibility of genetic testing, it is likely that these tools will be integrated earlier in the diagnostic process, potentially improving prognostic assessments and treatment outcomes.Conclusion: The importance of early and accurate identification of the cause is essential to inform clinical management, improve fetal survival rates and support parental decision-making.","PeriodicalId":12568,"journal":{"name":"Future Science OA","volume":"12 1","pages":"2681420"},"PeriodicalIF":2.5,"publicationDate":"2026-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13240947/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148149335","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Multi-omics analysis identified SPRR2D as a potential biomarker for tumor prognosis and immune microenvironment infiltration: a pan-cancer perspective. 多组学分析发现SPRR2D是肿瘤预后和免疫微环境浸润的潜在生物标志物：泛癌症视角。

IF 2.5

Future Science OA Pub Date : 2026-12-01 Epub Date: 2026-04-03 DOI: 10.1080/20565623.2026.2653101

Yuan-Xiang Shi

{"title":"Multi-omics analysis identified SPRR2D as a potential biomarker for tumor prognosis and immune microenvironment infiltration: a pan-cancer perspective.","authors":"Yuan-Xiang Shi","doi":"10.1080/20565623.2026.2653101","DOIUrl":"10.1080/20565623.2026.2653101","url":null,"abstract":"Background: Clarification of the molecular mechanism of malignant tumor progression, identification of the key signaling pathways and molecules involved in the processes of invasion and metastasis, and identification of new targets and strategies for effective tumor treatment are extremely important for scientific research and clinical application prospects.Methods: Based on large-sample data mining, we first evaluated the expression and mutation profiles of SPRR family genes across cancers and then focused on the molecular functions of SPRR2D across cancers.Results: Multi-omics experiments revealed that SPRR2D is significantly overexpressed in various tumors, especially in LUSC. ROC curve analysis revealed that SPRR2D demonstrated significant diagnostic efficacy across cancers. Cox regression analysis revealed that the expression of SPRR2D was associated with the survival time of patients with various tumors. Moreover, the expression of SPRR2D is closely related to tumor immune infiltration. GDSC data analysis revealed that the expression levels of SPRR1A, SPRR1B, SPRR2A, SPRR3, and SPRR2D are negatively correlated with the sensitivity to gefitinib, trametinib, bosutinib, afatinib, lapatinib, and erlotinib.Conclusions: From a multi-omics perspective, it was revealed that SPRR2D plays a significant role in regulating tumorigenesis and drug sensitivity in tumors.","PeriodicalId":12568,"journal":{"name":"Future Science OA","volume":"12 1","pages":"2653101"},"PeriodicalIF":2.5,"publicationDate":"2026-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13051589/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147615756","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Combined impact of diabetes mellitus and hypertension on acute kidney injury and survival in critically ill patients: a decade of experience from a Jordanian Tertiary Hospital. 糖尿病和高血压对危重病人急性肾损伤和生存的综合影响：约旦一家三级医院的十年经验

IF 2.5

Future Science OA Pub Date : 2026-12-01 Epub Date: 2026-03-05 DOI: 10.1080/20565623.2026.2638366

Nosayba Al-Azzam, Sayer Al-Azzam, Reema Karasneh

{"title":"Combined impact of diabetes mellitus and hypertension on acute kidney injury and survival in critically ill patients: a decade of experience from a Jordanian Tertiary Hospital.","authors":"Nosayba Al-Azzam, Sayer Al-Azzam, Reema Karasneh","doi":"10.1080/20565623.2026.2638366","DOIUrl":"10.1080/20565623.2026.2638366","url":null,"abstract":"Aims: To examine the independent and combined effects of diabetes mellitus (DM) and hypertension (HTN) on acute kidney injury (AKI) and 90-day mortality in critically ill patients.Patients and methods: We retrospectively analyzed 3,282 adult intensive care unit (ICU) admissions to King Abdullah University Hospital, Jordan (2012-2022). Patients were stratified by DM and HTN status. Logistic regression identified predictors of AKI, and Cox proportional hazards models assessed 90-day mortality.Results: AKI occurred in 44.7% of DM patients versus 40.8% without DM (p = 0.0423). Patients with both DM and HTN had the highest AKI incidence (48.6%) and the highest 90-day mortality (37.8%). In addition, the HTN × DM interaction was a significant predictor of AKI in multivariable analysis (OR = 1.18, 95% CI: 1.07-1.36, p = 0.0059) and increased the mortality hazard independently (HR = 1.43, 95% CI: 1.04-1.97, p = 0.0286).Conclusions: DM is associated with increased AKI and mortality in critically ill patients, and concurrent HTN further amplifies these risks. These findings support integrated cardiometabolic risk assessment in ICU settings.","PeriodicalId":12568,"journal":{"name":"Future Science OA","volume":"12 1","pages":"2638366"},"PeriodicalIF":2.5,"publicationDate":"2026-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12969735/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147354696","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Evaluation of a multi-component dietary supplement combined with probiotic and omega-3 in individuals with self-reported symptoms of brain fog: an 8-week exploratory study. 多组分膳食补充剂结合益生菌和omega-3对自我报告脑雾症状的个体的评估：一项为期8周的探索性研究

IF 2.5

Future Science OA Pub Date : 2026-12-01 Epub Date: 2026-04-11 DOI: 10.1080/20565623.2026.2654776

Abeer M Al-Ghananeem, Debbie T Combs Cantrell, Dennis Song, Ammar Jairoun

{"title":"Evaluation of a multi-component dietary supplement combined with probiotic and omega-3 in individuals with self-reported symptoms of brain fog: an 8-week exploratory study.","authors":"Abeer M Al-Ghananeem, Debbie T Combs Cantrell, Dennis Song, Ammar Jairoun","doi":"10.1080/20565623.2026.2654776","DOIUrl":"10.1080/20565623.2026.2654776","url":null,"abstract":"Aims: This study used an open-label design, comprising a one-arm eight-weeks-long study, and aimed to evaluate patient satisfaction and the efficacy of a novel dietary supplement composition combined with probiotic and omega-3 to support brain health improvement in 39 participants with confirmed or suspected brain fog caused by trauma, disease, exposure to chemotherapeutics, or similar events.Methods: The primary measure was the change from baseline in survey scores of the Montreal Cognitive Assessment. The secondary outcome was the change from baseline in test scores of the self-reported survey.Results: The results indicated significant improvements across all domains over time (p < 0.0001), with the most substantial changes occurring by Week 8. Repeated-measures analysis of variance showed a significant time effect (F [2.811, 105.4] = 43.09, p < 0.0001), suggesting that cognitive scores progressively improved across the weeks.Conclusions: This exploratory research indicates that the trial kit was feasible, well tolerated, and associated with improvements in exploratory cognitive measures and perceived well-being over an eight-week period, although practice and placebo effects cannot be ruled out. The findings are hypothesis-generating and support further evaluations in randomized, placebo-controlled studies using well-characterized interventions, objective adherence measures, and biomarker-based outcomes.","PeriodicalId":12568,"journal":{"name":"Future Science OA","volume":"12 1","pages":"2654776"},"PeriodicalIF":2.5,"publicationDate":"2026-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13078196/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147653918","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

An experimental study on the role of naloxone in facilitating alcohol metabolism in acute alcohol intoxication rats. 纳洛酮促进急性酒精中毒大鼠酒精代谢的实验研究。

IF 2.5

Future Science OA Pub Date : 2026-12-01 Epub Date: 2026-07-06 DOI: 10.1080/20565623.2026.2698022

Ziqi Jin, Yingqi Hu, Xuqi Liu, Yingying Cao, Jiayi Zhang, Runa A, Xiaoxue Wang, Lingyu Zhang, Yongzhi Xue

{"title":"An experimental study on the role of naloxone in facilitating alcohol metabolism in acute alcohol intoxication rats.","authors":"Ziqi Jin, Yingqi Hu, Xuqi Liu, Yingying Cao, Jiayi Zhang, Runa A, Xiaoxue Wang, Lingyu Zhang, Yongzhi Xue","doi":"10.1080/20565623.2026.2698022","DOIUrl":"10.1080/20565623.2026.2698022","url":null,"abstract":"Objectives: Naloxone has been used in acute alcohol intoxication (AAI) in China and some other Asian countries. However, the effects of naloxone on alcohol metabolism and its mechanisms are unclear. This study aimed to explore the role of naloxone in facilitating alcohol metabolism.Methods: AAI rat model was established by force-feeding alcohol. The effect of naloxone in facilitating alcohol metabolism was detected using an improved breathalyzer. The open field test (OFT) was also used to observe the behavioral changes in rats.Results: By breathalyzer, naloxone could promote alcohol metabolism in a dose-dependent manner. Naloxone could promote the arousal of rats and increase the spontaneous activity of rats. But Cytochrome P450 2E1 (CYP2E1) protein and mRNA showed no significant changes. Naloxone promotes alcohol metabolism, and the changing trend of blood alcohol concentration shows a good pharmacokinetics-pharmacodynamics (PK-PD) correlation with adrenocorticotropic hormone (ACTH) expression and behavioral changes in rats.Conclusion: We established a method via gas collection bottles to evaluate the metabolic activity of CYP2E1 and alcohol dehydrogenase (ADH) in rats and established a metabolic model reflecting the changes in segmented alcohol concentrations over time. Naloxone could promote alcohol metabolism by promoting arousal, which is beneficial to AAI.","PeriodicalId":12568,"journal":{"name":"Future Science OA","volume":"12 1","pages":"2698022"},"PeriodicalIF":2.5,"publicationDate":"2026-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13348912/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148390489","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Pathway dysregulation and therapeutic resistance in glioblastoma: molecular mechanisms and emerging therapeutic targets. 胶质母细胞瘤通路失调和治疗耐药：分子机制和新出现的治疗靶点。

IF 2.5

Future Science OA Pub Date : 2026-12-01 Epub Date: 2026-08-10 DOI: 10.1080/20565623.2026.2715646

William Li, Jia Ming Chen, Yi Chao Ma

引用次数: 0