Future Science OAPub Date : 2024-12-31Epub Date: 2024-08-07DOI: 10.2144/fsoa-2023-0222
Bahaeddine Lahbacha, Abir Chaabane, Wafa Garbouj, Roua Mankai, Amina Bani, Amal Khsiba, Raja Amri, Salwa Nechi, Emna Chelbi
{"title":"Liver biopsy revealing anti-neutrophil cytoplasmic antibody-associated vasculitis: a tale for a challenging diagnosis.","authors":"Bahaeddine Lahbacha, Abir Chaabane, Wafa Garbouj, Roua Mankai, Amina Bani, Amal Khsiba, Raja Amri, Salwa Nechi, Emna Chelbi","doi":"10.2144/fsoa-2023-0222","DOIUrl":"10.2144/fsoa-2023-0222","url":null,"abstract":"<p><p>A 62-year-old woman presented with a chronic fever and fatigue. Biological investigations showed leukocytosis and elevation of acute phase markers. Liver blood tests showed deterioration with both cholestatic and hepatocellular patterns (there were, respectively, elevations in serum alkaline phosphatase levels as well as in serum alanine and aspartate aminotransferases). Viral serologies were negative. Mycobacterial infection and endocarditis were excluded. Results from blood cultures were negative. Autoantibody tests including ANCA (anti-neutrophil cytoplasmic antibody), anti-nuclear, anti-smooth muscle and anti-mitochondria were all negative. A liver biopsy revealed epithelioid granulomatous necrotizing vasculitis. Subsequently, immunological testing was repeated revealing MPO-ANCA (myeloperoxidase-ANCA). A diagnosis of ANCA-associated vasculitis with liver involvement was then made. The patient was started on steroids and her clinical state gradually improved.</p>","PeriodicalId":12568,"journal":{"name":"Future Science OA","volume":null,"pages":null},"PeriodicalIF":2.4,"publicationDate":"2024-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11318729/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141897250","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Endoscope disinfectant-induced colonic pseudolipomatosis: case series of a rare condition.","authors":"Charfeddine Baccouche, Myriam Ayari, Imen Abdelaali, Amen Dhaoui, Taieb Jomni, Mohamed Hedi Douggui","doi":"10.2144/fsoa-2023-0210","DOIUrl":"10.2144/fsoa-2023-0210","url":null,"abstract":"<p><p><b>Aim:</b> Colonic mucosal pseudolipomatosis is a rare and benign endoscopic finding with distinct macroscopic and histological characteristics. <b>Case series:</b> We observed a form of unprecedented colitis in eight patients in a 3-month period. Operators have found, during colonoscopy, flat or slightly raised whitish-yellow plaques, in the colonic mucosa of all patients. Histological examination concluded to pseudolipomatosis. After investigation, the disinfectant machine was found to have technical malfunctioning of the rinse cycle of the endoscope during this period. No other cases were observed after the machine was fixed. <b>Conclusion:</b> Pseudolipomatosis is more an endoscopically induced lesion than a true pathological condition. A careful check of the disinfection process should be carried out when such lesions are detected.</p>","PeriodicalId":12568,"journal":{"name":"Future Science OA","volume":null,"pages":null},"PeriodicalIF":2.5,"publicationDate":"2024-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11172253/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141310455","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Future Science OAPub Date : 2024-12-31Epub Date: 2024-09-09DOI: 10.1080/20565623.2024.2387961
Aurelia Rughetti, Shreya Bharti, Rajkumar Savai, Spyridoula Barmpoutsi, Andreas Weigert, Rajat Atre, Faaiza Siddiqi, Rahul Sharma, Rakhi Khabiya, Nik Hirani, Mirza S Baig
{"title":"Imperative role of adaptor proteins in macrophage toll-like receptor signaling pathways.","authors":"Aurelia Rughetti, Shreya Bharti, Rajkumar Savai, Spyridoula Barmpoutsi, Andreas Weigert, Rajat Atre, Faaiza Siddiqi, Rahul Sharma, Rakhi Khabiya, Nik Hirani, Mirza S Baig","doi":"10.1080/20565623.2024.2387961","DOIUrl":"10.1080/20565623.2024.2387961","url":null,"abstract":"<p><p>Macrophages are integral part of the body's defense against pathogens and serve as vital regulators of inflammation. Adaptor molecules, featuring diverse domains, intricately orchestrate the recruitment and transmission of inflammatory responses through signaling cascades. Key domains involved in macrophage polarization include Toll-like receptors (TLRs), Src Homology2 (SH2) and other small domains, alongside receptor tyrosine kinases, crucial for pathway activation. This review aims to elucidate the enigmatic role of macrophage adaptor molecules in modulating macrophage activation, emphasizing their diverse roles and potential therapeutic and investigative avenues for further exploration.</p>","PeriodicalId":12568,"journal":{"name":"Future Science OA","volume":null,"pages":null},"PeriodicalIF":2.4,"publicationDate":"2024-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11385170/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142153612","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Future Science OAPub Date : 2024-12-31Epub Date: 2024-07-09DOI: 10.1080/20565623.2024.2367956
Burhanuddin Sohail Rangwala, Varisha Zuhair, Muhammad Saqlain Mustafa, Abdullah Mussarat, Aimen Waqar Khan, Fnu Danish, Syeda Mahrukh Fatima Zaidi, Faizan Ur Rehman, Muhammad Ashir Shafique
{"title":"Ferric carboxymaltose for iron deficiency in patients with heart failure: a systematic review and meta-analysis.","authors":"Burhanuddin Sohail Rangwala, Varisha Zuhair, Muhammad Saqlain Mustafa, Abdullah Mussarat, Aimen Waqar Khan, Fnu Danish, Syeda Mahrukh Fatima Zaidi, Faizan Ur Rehman, Muhammad Ashir Shafique","doi":"10.1080/20565623.2024.2367956","DOIUrl":"10.1080/20565623.2024.2367956","url":null,"abstract":"<p><p><b>Aim:</b> Iron deficiency (ID) is associated with heart failure (HF) in a considerable proportion of patients. To improve the quality of life, lower the frequency of hospitalizations, and lower mortality rates of chronic HF patients (HF), this meta-analysis will look into the role of iron supplementation using ferric carboxymaltose (FCM). <b>Methods & results:</b> From inception until 1 October 2023, we conducted a thorough literature search of electronic databases for peer-reviewed publications. Around 5229 HF patients were included, of which 2691 received FCM while 2538 received placebo. <b>Conclusion:</b> FCM reduces HF-related hospitalizations but doesn't improve overall or cardiovascular mortality in those with HF and ID. The overall results support FCM's role in managing iron deficiency in heart failure.</p>","PeriodicalId":12568,"journal":{"name":"Future Science OA","volume":null,"pages":null},"PeriodicalIF":2.4,"publicationDate":"2024-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11238921/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141563145","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Future Science OAPub Date : 2024-12-31Epub Date: 2024-08-22DOI: 10.1080/20565623.2024.2389664
Mirette A Morgan, Sarra E Saleh, Azza H Salamoni, Mohammad Y Alshahrani, Khaled M Aboshanab
{"title":"Hematological, inflammatory and serological responses among COVID-19 patients admitted to intensive care unit.","authors":"Mirette A Morgan, Sarra E Saleh, Azza H Salamoni, Mohammad Y Alshahrani, Khaled M Aboshanab","doi":"10.1080/20565623.2024.2389664","DOIUrl":"10.1080/20565623.2024.2389664","url":null,"abstract":"<p><p><b>Aim:</b> To correlate hematological, inflammatory indicators and serological responses among COVID-19 patients to point out the significant biomarkers for disease management and prognosis.<b>Materials & methods:</b> Standard analytical and molecular methods were used to assess various inflammatory and serological Responses among COVID-19 patients (ICU- (n = 99) and non-ICU patients (n = 64) as compared with health control (n = 40).<b>Results:</b> Significant differences in the Hb, WBC, Lymphocyte count, CRP and serum ferritin (<i>p</i> < 0.05) were observed. Patients' IgM/IgG antibodies against SARS-CoV-2 were associated with increased CRP, LDH and serum ferritin levels.<b>Conclusion:</b> A significant association between serum IgG/IgM and ICU admission was observed. Although serum ferritin and LDH can offer information about the extent of inflammation, they are exclusive factors for ICU admission.</p>","PeriodicalId":12568,"journal":{"name":"Future Science OA","volume":null,"pages":null},"PeriodicalIF":2.4,"publicationDate":"2024-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11346553/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142035644","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Future Science OAPub Date : 2024-12-31Epub Date: 2024-08-25DOI: 10.1080/20565623.2024.2365125
Syed Hamza Haider, Areeka Irfan, Samir Mustafa Sheikh, Muhammad Taha Abid, Turba Naz, Mudassir Abbas, Alishba Raza
{"title":"Evaluating the impact of testosterone replacement therapy on carotid atherosclerosis: a systematic review and meta-analysis.","authors":"Syed Hamza Haider, Areeka Irfan, Samir Mustafa Sheikh, Muhammad Taha Abid, Turba Naz, Mudassir Abbas, Alishba Raza","doi":"10.1080/20565623.2024.2365125","DOIUrl":"10.1080/20565623.2024.2365125","url":null,"abstract":"<p><p><b>Aim:</b> This meta-analysis investigates the association between testosterone replacement therapy [TRT] and carotid artery atherosclerosis. <b>Methods:</b> 3 databases were searched for studies up to June 2023 per the PRISMA guidelines. The eligibility criteria comprised RCTs and observational studies involving hypogonadal males receiving exogenous testosterone, in which CIMT was assessed. CAA was the primary outcome, whereas secondary outcomes included HDL, LDL, CRP, total cholesterol and total testosterone. The statistical analysis was performed using Review Manager. <b>Results:</b> Statistical analysis revealed no association between TRT and assessed outcomes. There was a significant increase in total testosterone levels, depicting indirect anti-atherosclerotic effects of TRT. <b>Conclusion:</b> Meta-analysis shows no relation between TRT and CIMT or other markers, allowing its safe usage for hypogonadal males.</p>","PeriodicalId":12568,"journal":{"name":"Future Science OA","volume":null,"pages":null},"PeriodicalIF":2.4,"publicationDate":"2024-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11352792/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142055359","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Formulation and characterization of antibiotic drug loaded aquasome for the topical application.","authors":"Bhuvaneshwari Shanmugam, Umashankar Marakanam Srinivasan","doi":"10.1080/20565623.2024.2367849","DOIUrl":"10.1080/20565623.2024.2367849","url":null,"abstract":"<p><p><b>Aim:</b> This study aimed to develop a topical antibiotic drug delivery system using aquasomes for enhanced treatment of skin and soft tissue infections (SSTIs). <b>Materials & methods:</b> Cephalothin was loaded into aquasomes using a multi-step process and optimized using design of experiment. The aquasomes were characterized for FT-IR, SEM and zeta potential analysis. Entrapment efficacy, <i>In vitro</i> drug release studies, antibacterial assays and stability study was performed to evaluate the efficacy of the formulated aquasomes. <b>Results & conclusion:</b> The formulated cephalothin-loaded aquasomes exhibited stable properties, controlled drug release and significant antibacterial activity against bacteria. This proves that the developed aquasome-based delivery system has the potential for sustained treatment of SSTIs.</p>","PeriodicalId":12568,"journal":{"name":"Future Science OA","volume":null,"pages":null},"PeriodicalIF":2.4,"publicationDate":"2024-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11238917/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141563146","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Clinical treatment strategy and follow-up of lymphoepithelioma-like carcinoma: a retrospective study.","authors":"Shilong Zhang, Yufu Lin, Zhiyong Li, Zhiming Wang, Rongkui Luo, Xiuping Zhang","doi":"10.1080/20565623.2024.2384878","DOIUrl":"10.1080/20565623.2024.2384878","url":null,"abstract":"<p><p><b>Aim:</b> To investigate the clinical features, diagnosis and treatment of lymphoepithelioma-like carcinoma (LELC).<b>Materials & methods:</b> The clinical data of 114 LELC patients were retrospectively analyzed.<b>Results:</b> Ninety-eight patients (86.0%) were Epstein-Barr virus-encoded small RNA (EBER) positive detected by situ hybridization. A 67.1% (51/76) patients had PD-L1 expression. The 5-year overall survival rate of EBER negative patients was 51.6% while the rate of positive patients was 84.8% (<i>p</i> = 0.015). The 5-year progression free survival rate of EBER negative patients was 40.2% while the rate of positive patients was 70.2% (<i>p</i> = 0.004).<b>Conclusion:</b> The progression of LELC is relatively slow and present a better prognosis. The occurrence of tumor is closely related to Epstein-Barr virus infection and PD-L1 is highly expressed in tumor cells.</p>","PeriodicalId":12568,"journal":{"name":"Future Science OA","volume":null,"pages":null},"PeriodicalIF":2.4,"publicationDate":"2024-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11385158/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142106382","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Future Science OAPub Date : 2024-12-31Epub Date: 2024-08-14DOI: 10.1080/20565623.2024.2380590
Saqib Rauf, Sami Ullah, Muhammad Adil Abid, Asad Ullah, Gullzar Khan, Ainee Urooj Khan, Gulzar Ahmad, Muhammad Ijaz, Sidra Ahmad, Sulaiman Faisal
{"title":"A computational study of gene expression patterns in head and neck squamous cell carcinoma using TCGA data.","authors":"Saqib Rauf, Sami Ullah, Muhammad Adil Abid, Asad Ullah, Gullzar Khan, Ainee Urooj Khan, Gulzar Ahmad, Muhammad Ijaz, Sidra Ahmad, Sulaiman Faisal","doi":"10.1080/20565623.2024.2380590","DOIUrl":"10.1080/20565623.2024.2380590","url":null,"abstract":"<p><p><b>Aim:</b> Head and Neck squamous cell carcinoma (HNSCC) is the second most prevalent cancer in Pakistan. <b>Methods:</b> Gene expression data from TCGA and GETx for normal genes to analyze Differentially Expressed Genes (DEGs). Data was further investigated using the Enrichr tool to perform Gene Ontology (GO). <b>Results:</b> Our analysis identified most significantly differentially expressed genes and explored their established cellular functions as well as their potential involvement in tumor development. We found that the highly expressed Keratin family and <i>S100A9</i> genes. The under-expressed genes <i>KRT4</i> and <i>KRT13</i> provide instructions for the production of keratin proteins. <b>Conclusion:</b> Our study suggests that factors such as poor oral hygiene and smokeless tobacco can result in oral stress and cellular damage and cause cancer.</p>","PeriodicalId":12568,"journal":{"name":"Future Science OA","volume":null,"pages":null},"PeriodicalIF":2.4,"publicationDate":"2024-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11326450/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141975490","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Future Science OAPub Date : 2024-12-31Epub Date: 2024-09-10DOI: 10.1080/20565623.2024.2395244
Luu Hong Dang Nguyen, Ba Linh Tieu, Thi Thanh Nguyen, Nhung Phuong Ha, Giang Thi Huong Nguyen, Thi Hue Hanh Nguyen, Van Hoi Le, Vinh Quang Bui, Lan Hieu Nguyen, Nhu Hiep Pham, Thanh Hai Phan, Huu Thinh Nguyen, Van Song Tran, Chi Viet Bui, Van Kha Vo, Pham Thanh Nhan Nguyen, Ha Huu Phuoc Dang, Van Dung Pham, Van Thinh Cao, Ngoc Minh Phan, Van Tung Nguyen, Thi Le Quyen Le, Thi Lan-Anh Luong, Thi Kim Phuong Doan, Canh Duy Phan, Thanh Xuan Nguyen, Nguyen Tuong Pham, Bao Toan Nguyen, Thi Thu Thuy Pham, Huu Linh Le, Cong Thanh Truong, Thanh Xuan Jasmine, Minh Chi Le, Van Bau Phan, Quang Binh Truong, Thi Huong Ly Tran, Minh Thien Huynh, Tu Quy Tran, Si Tuan Nguyen, Vu Tran, Van Khanh Tran, Huu Nguyen Nguyen, Thi Van Phan, Thi Thanh-Thuy Do, Dinh Kiet Truong, Hoa Giang, Hoai-Nghia Nguyen, Minh-Duy Phan, Le Son Tran, Hung Sang Tang, Duy Sinh Nguyen
{"title":"A consultation and work-up diagnosis protocol for a multicancer early detection test: a case series study.","authors":"Luu Hong Dang Nguyen, Ba Linh Tieu, Thi Thanh Nguyen, Nhung Phuong Ha, Giang Thi Huong Nguyen, Thi Hue Hanh Nguyen, Van Hoi Le, Vinh Quang Bui, Lan Hieu Nguyen, Nhu Hiep Pham, Thanh Hai Phan, Huu Thinh Nguyen, Van Song Tran, Chi Viet Bui, Van Kha Vo, Pham Thanh Nhan Nguyen, Ha Huu Phuoc Dang, Van Dung Pham, Van Thinh Cao, Ngoc Minh Phan, Van Tung Nguyen, Thi Le Quyen Le, Thi Lan-Anh Luong, Thi Kim Phuong Doan, Canh Duy Phan, Thanh Xuan Nguyen, Nguyen Tuong Pham, Bao Toan Nguyen, Thi Thu Thuy Pham, Huu Linh Le, Cong Thanh Truong, Thanh Xuan Jasmine, Minh Chi Le, Van Bau Phan, Quang Binh Truong, Thi Huong Ly Tran, Minh Thien Huynh, Tu Quy Tran, Si Tuan Nguyen, Vu Tran, Van Khanh Tran, Huu Nguyen Nguyen, Thi Van Phan, Thi Thanh-Thuy Do, Dinh Kiet Truong, Hoa Giang, Hoai-Nghia Nguyen, Minh-Duy Phan, Le Son Tran, Hung Sang Tang, Duy Sinh Nguyen","doi":"10.1080/20565623.2024.2395244","DOIUrl":"https://doi.org/10.1080/20565623.2024.2395244","url":null,"abstract":"<p><p>The emergence of multicancer early detection (MCED) tests holds promise for improving early cancer detection and public health outcomes. However, positive MCED test results require confirmation through recommended cancer diagnostic imaging modalities. To address these challenges, we have developed a consultation and work-up protocol for definitive diagnostic results post MCED testing, named SPOT-MAS. Developed through circulating tumor DNA (ctDNA) analysis and in line with professional guidelines and advisory board consensus, this protocol standardizes information to aid general practitioners in accessing, interpreting and managing SPOT-MAS results. Clinical effectiveness is demonstrated through a series of identified cancer cases. Our research indicates that the protocol could empower healthcare professionals to confidently interpret circulating tumor DNA test results for 5 common types of cancer, thereby facilitating the clinical integration of MCED tests.</p>","PeriodicalId":12568,"journal":{"name":"Future Science OA","volume":null,"pages":null},"PeriodicalIF":2.4,"publicationDate":"2024-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11389743/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142283896","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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