Future Science OA最新文献_第2页

On the mode of anti-C. albicans activity of a bis(benzoxaborole) analogue of tavaborole. 论反c的模态。白念珠菌活性的他瓦波罗的苯并oxaborole类似物。

IF 2.1

Future Science OA Pub Date : 2026-12-01 Epub Date: 2026-04-28 DOI: 10.1080/20565623.2026.2661523

Sachin Gadakh, Teresa Szczepińska, Małgorzata Potoczna, Shiho Okitsu-Sakurayama, Piotr Podlasz, Marta Rogalska, Ewa Kaczorowska, Agnieszka Adamczyk-Woźniak, Monika Staniszewska

{"title":"On the mode of anti-C. albicans activity of a bis(benzoxaborole) analogue of tavaborole.","authors":"Sachin Gadakh, Teresa Szczepińska, Małgorzata Potoczna, Shiho Okitsu-Sakurayama, Piotr Podlasz, Marta Rogalska, Ewa Kaczorowska, Agnieszka Adamczyk-Woźniak, Monika Staniszewska","doi":"10.1080/20565623.2026.2661523","DOIUrl":"10.1080/20565623.2026.2661523","url":null,"abstract":"Background: Benzoxaboroles showed significant antimicrobial efficacy in the past, warranting further investigation.Research design and methods: Benzoxaboroles were evaluated for their cytotoxicity on Vero E6 and PBMCs, as well as their embryotoxicity in zebrafish embryos. Benzoxaboroles' impact on C. albicans in planktonic and biofilm was assessed. Advanced microscopy provided insights into C. albicans viability, while RNA-seq identified differentially expressed genes, with docking studies underscoring the potential of benzoxaboroles against fungi.Results: Bis(benzoxazole) analog (2) and Tavaborole effectively inhibited C. albicans, decreasing viability to 80% at 64 µg/mL compared to 60% at 16 µg/mL. The biofilm-inhibiting concentration (BIC50) was 2 μg/mL, leading to a 50% reduction in biofilm activity. 2 exhibited limited morphogenesis, it displayed significantly lower embryotoxicity compared to Tavaborole, with an IC50 greater than 128 μg/mL. 2 maintained approximately 80% viability of VERO E6 at 64 μg/mL. 2 reported an IC50 of 2 μg/mL against PBMCs. RNA-seq revealed upregulation of efflux pumps (MDR) and downregulation of inositol-1-phosphate synthase during benzoxazole treatment. Docking studies confirmed interactions with LeuRS.Conclusions: Benzoxaboroles exhibited a similar resistance to azoles, which is associated with increased MDR1 and IDH6 levels. Efflux inhibitors for benzoxaboroles were crucial for treating candidiasis and may inspire future antifungal research.","PeriodicalId":12568,"journal":{"name":"Future Science OA","volume":"12 1","pages":"2661523"},"PeriodicalIF":2.1,"publicationDate":"2026-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13128027/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147768918","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Factors influencing the prediction of obstructive sleep apnea: an observational study from a developing country. 影响阻塞性睡眠呼吸暂停预测的因素：一项来自发展中国家的观察性研究。

IF 2.1

Future Science OA Pub Date : 2026-12-01 Epub Date: 2026-01-19 DOI: 10.1080/20565623.2026.2615969

Noor Al Mortadi, Lina Khasawneh, Basheer Khassawneh, Abedelmalek K Tabnjh, Karem H Alzoubi

{"title":"Factors influencing the prediction of obstructive sleep apnea: an observational study from a developing country.","authors":"Noor Al Mortadi, Lina Khasawneh, Basheer Khassawneh, Abedelmalek K Tabnjh, Karem H Alzoubi","doi":"10.1080/20565623.2026.2615969","DOIUrl":"10.1080/20565623.2026.2615969","url":null,"abstract":"Aim: Upper airway anatomy is important in obstructive sleep apnea (OSA). This study conducted a correlation analysis between the apnea-hypopnea index (AHI) score and upper airway measurements obtained from cone-beam computed tomography (CBCT), arch measurements obtained from diagnostic casts, and subjective data from patients' records, including the Berlin Sleep Questionnaire and Epworth Sleepiness Scale.Methods: Twenty-five subjects with a confirmed diagnosis of OSA via polysomnography with a mean AHI of 25.5 (SD18.5) were enrolled in this study.Results: A significant correlation was found between the AHI score and the following factors: male sex, obesity categories, Berlin questionnaire category, sleep efficiency, and maxillary intermolar width measured between the mesiobuccal cusp tip of the right and left first molars. Airway measurements from CBCT, including anterior cranial base length, facial proportion, and the length of the soft palate in the mid-sagittal plane and the retroglossal area in the axial plane, were significantly correlated with the AHI score.Conclusion: In addition to male gender and obesity, anatomic factors related to upper airway measurements on CBCT are significantly correlated with AHI, indicating upper airway limitations, OSA severity, and aiding early diagnosis.","PeriodicalId":12568,"journal":{"name":"Future Science OA","volume":"12 1","pages":"2615969"},"PeriodicalIF":2.1,"publicationDate":"2026-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12826696/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145997825","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Systematic review of the literature: estimation of the most common gynecological disorders and associated factors among Kazakhstani adolescents. 文献的系统回顾：哈萨克斯坦青少年中最常见的妇科疾病和相关因素的估计。

IF 2.1

Future Science OA Pub Date : 2026-12-01 Epub Date: 2025-12-13 DOI: 10.1080/20565623.2025.2599726

Saule Kurbaniyazova, Raushan Nurkhasimova, Ardak Ayazbekov, Saltanat Khudaibergenova, Saltanat Kulbayeva, Dinara Mirzakhmetova, Kenzhegul Ryskeldiyeva

引用次数: 0

Autophagy targeted nano-medicine in norphytane atrophic arthritis model: Beclin1/XBP/PTEN/STAT-3A genetic profile. 自噬靶向纳米药物在norphytane萎缩性关节炎模型中的作用：Beclin1/XBP/PTEN/STAT-3A基因谱

IF 2.1

Future Science OA Pub Date : 2026-12-01 Epub Date: 2026-01-12 DOI: 10.1080/20565623.2025.2580892

Mai O Kadry, Rehab M Abdel-Megeed

{"title":"Autophagy targeted nano-medicine in norphytane atrophic arthritis model: Beclin1/XBP/PTEN/STAT-3A genetic profile.","authors":"Mai O Kadry, Rehab M Abdel-Megeed","doi":"10.1080/20565623.2025.2580892","DOIUrl":"10.1080/20565623.2025.2580892","url":null,"abstract":"Background and objectives: Targeting macro-autophagy (MAut) through Nano-medicine can be more prospective than traditional medicine subjected to resistance in atrophic arthritis (RA). MAut is a degenerative process that restores healthy chondrocytes it plays a vital role in RA onset and cell homeostasis this opened Novel Avenue in targeting RA via liposomal drug delivery system. The insufficient response to existing therapies or systemic toxicity and poor bioavailability, are quiet unsettled problems lying across the full retardation of RA treatment. Various Nano-carriers with sustained drug release, improved physicochemical properties, and active targeting were designed to promote the drug delivery efficiency.Methods: Single subcutaneous dose of Norphytane (200 μL) induced Atrophic arthritis in rat model then rats were treated with Liposomal loaded-Isethione or Isethione.Results: Liposomal-Isethione ameliorated autophagy biomarkers including Beclin-1, P62, and X-box binding protein-1 (XBP-1), cell survival, and oncogenic biomarkers including Signal transducer and activator of transcription (STAT-3A), Phosphoinisitol kinase-3 (PI3K), AKT Serine/Threonine Kinase-1 (AKT), and Phosphatase and tensin homolog (PTEN) post elevation via Norphytane. Moreover, rheumatoid factor biomarkers including Cartilage oligomeric matrix protein (COMP), matrix metalloproteinase (MMP-9), tumor necrosis factor (TNF-α).Conclusion: Liposomal-Isethione significantly targeted MAut signaling pathways, including Beclin-1/XBP/COMP/STAT-3A/PI3K/AKT/PTEN via increased bioavailability and targeting inflamed tissues, thus decreased drug resistance.","PeriodicalId":12568,"journal":{"name":"Future Science OA","volume":"12 1","pages":"2580892"},"PeriodicalIF":2.1,"publicationDate":"2026-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12802997/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145959172","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Intra-articular injection of high versus low molecular weight hyaluronic acid in adhesive capsulitis; randomized trial. 关节内注射高分子量透明质酸与低分子量透明质酸治疗粘连性囊炎随机试验。

IF 2.1

Future Science OA Pub Date : 2026-12-01 Epub Date: 2025-12-24 DOI: 10.1080/20565623.2025.2581460

Mahshad Mir, Rezvaneh Mohebbi, Ghader Mohammadnezhad, Seyed Ahmad Raeissadat, Alireza Parhizgar, Hadi Esmaily

{"title":"Intra-articular injection of high versus low molecular weight hyaluronic acid in adhesive capsulitis; randomized trial.","authors":"Mahshad Mir, Rezvaneh Mohebbi, Ghader Mohammadnezhad, Seyed Ahmad Raeissadat, Alireza Parhizgar, Hadi Esmaily","doi":"10.1080/20565623.2025.2581460","DOIUrl":"10.1080/20565623.2025.2581460","url":null,"abstract":"Background: Adhesive capsulitis (AC) is a chronic inflammatory condition with limited range of motion (ROM) in the glenohumeral joint. The main goals in managing AC are pain reduction and returning joint function. Intra-articular hyaluronic acid (HA) has been considered a safe modality in AC. This study compared the effectiveness of intra-articular injection of low molecular weight (LMW) with high molecular weight (HMW) HA in patients with AC.Methods: Fifty-six patients with AC were randomized in this triple-blinded clinical trial. All underwent standard physical therapy. The outcomes were visual analog scale (VAS), Oxford shoulder score (OSS), active ROM, and patient satisfaction at 4, 12, and 24 weeks.Results: No significant differences were detected in between-group variables at baseline. Both groups showed marked improvement in VAS, OSS, and ROM over time. At four weeks LMW-HA group had lower pain (P = 0.049). Conversely, the trend of VAS at 12-week and 24-week endpoints favors HMW-HA (Baseline to endpoint: -5.48 ± 1.68 and -3.91 ± 1.31 reduction in VAS as the primary outcome, P < 0.001). Satisfaction had significantly improved in both groups.Conclusion: HMW-HA was associated with greater pain reduction and functional improvement compared with LMW-HA.Trial registration: The trial protocol was registered at the Iranian Registry of Clinical Trials (IRCT), a WHO Primary Register setup (registration No: IRCT20170608034390N4; First registration date: 01/01/2020).","PeriodicalId":12568,"journal":{"name":"Future Science OA","volume":"12 1","pages":"2581460"},"PeriodicalIF":2.1,"publicationDate":"2026-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12758168/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145818919","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Association between circadian rhythm-related behaviors and breast cancer: a bidirectional Mendelian randomization study. 昼夜节律相关行为与乳腺癌之间的关系：一项双向孟德尔随机研究。

IF 2.1

Future Science OA Pub Date : 2026-12-01 Epub Date: 2026-02-27 DOI: 10.1080/20565623.2026.2631966

Yan-Yu Hou, Hua-Tao Wu, Wen-Jia Chen, Yang-Zheng Lan, Xin-Ning Yu, Jing Liu

{"title":"Association between circadian rhythm-related behaviors and breast cancer: a bidirectional Mendelian randomization study.","authors":"Yan-Yu Hou, Hua-Tao Wu, Wen-Jia Chen, Yang-Zheng Lan, Xin-Ning Yu, Jing Liu","doi":"10.1080/20565623.2026.2631966","DOIUrl":"10.1080/20565623.2026.2631966","url":null,"abstract":"Background: Breast cancer (BC) is a major cause of cancer-related morbidity and mortality in women, with its development linked to circadian rhythm disruption. This study employs two-sample bidirectional Mendelian randomization (MR) to explore their causal relationship.Materials and methods: Genome-wide association study (GWAS) from the MRC Integrated Epidemiology Unit (MRC IEU) on circadian rhythm-related behaviors and BC subtypes was used. Causal effects were assessed using multiple MR methods, with IVW as the primary approach. Sensitivity analyses were conducted to ensure result robustness.Results: Increased sleep duration was associated with a higher BC risk (IVW model: OR = 1.33, P < 0.001), while being a morning person (IVW model: OR = 0.76, P = 0.003) and getting up in the morning (IVW model: OR = 0.71, P < 0.001) were protective factors. Similar findings were observed for estrogen receptor-positive (ER+) BC. BC patients were also more likely to experience insomnia (IVW model: OR = 1.01, P < 0.001).Conclusion: Our bidirectional MR study provides genetic evidence for a causal link between genetically predicted circadian rhythm-related behaviors and BC. These findings underscore the role of genetic factors influencing circadian biology in BC etiology and warrant further investigation into the underlying mechanisms.","PeriodicalId":12568,"journal":{"name":"Future Science OA","volume":"12 1","pages":"2631966"},"PeriodicalIF":2.1,"publicationDate":"2026-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12962709/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147304709","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Preclinical assessment of GNE^wt/bi-shRNA-GNE^M743T lipoplex product development for GNE myopathy. GNEwt/bi-shRNA-GNEM743T脂质体产品开发治疗GNE肌病的临床前评估

IF 2.1

Future Science OA Pub Date : 2026-12-01 Epub Date: 2026-03-02 DOI: 10.1080/20565623.2026.2635722

Fabienne Kerneis, Christopher M Jay, Donald Rao, Jeremy Winchester, Alexander Nemunaitis, Emily Nemunaitis, Ernest Bognar, Gladice Wallraven, Laura Stanbery, Adam Walter, Sep Sarshar, John Nemunaitis

{"title":"Preclinical assessment of GNEwt/bi-shRNA-GNEM743T lipoplex product development for GNE myopathy.","authors":"Fabienne Kerneis, Christopher M Jay, Donald Rao, Jeremy Winchester, Alexander Nemunaitis, Emily Nemunaitis, Ernest Bognar, Gladice Wallraven, Laura Stanbery, Adam Walter, Sep Sarshar, John Nemunaitis","doi":"10.1080/20565623.2026.2635722","DOIUrl":"10.1080/20565623.2026.2635722","url":null,"abstract":"Aims: GNE myopathy is a heredity disease of unmet medical need associated with progressive skeletal muscle wasting, atrophy and weakness caused by mutations in the GNE gene. GNE plays a pivotal role in sialic acid production. Sialic acid is a critical part of glycoprotein, ganglioside and glycolipid cell-cell interaction which is necessary for normal skeletal muscle function. Previously we demonstrated safety and efficacy of the GNEwt gene lipoplex in one patient.Methods: We engineered GNEM743T and dual function GNEwt/bi-shRNA plasmids to evaluate GNEM743T specific knockdown and GNEwt expression. Knockdown efficiency, protein expression, and functional rescue were assessed. A dose range study in mice quantified plasmid delivery and human GNE expression in muscle.Results: We demonstrate effective plasmid function via knockdown of the GNEM743T gene mutation and concurrent expression of GNEwt gene in a dose dependent manner. Similar in vitro increase in sialic acid production is shown between prior single function plasmid and GNEwt/bi-shRNA-GNEM743T dual function plasmid. Moreover, we demonstrate murine in vivo muscle delivery and expression of GNEwt mRNA from the GNEwt/bi-shRNA-GNEM743T plasmid delivered via DOTAP-Cholesterol lipoplex following intravenous injection.Conclusion: These results encourage future studies, potentially leading toward clinical testing of GNEwt/bi-shRNA-GNEM743T lipoplex for GNE myopathy.","PeriodicalId":12568,"journal":{"name":"Future Science OA","volume":"12 1","pages":"2635722"},"PeriodicalIF":2.1,"publicationDate":"2026-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12962615/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147325607","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Continuous spinal anesthesia for TURBT in a morbidly obese patient with EF of 20%: a case report. 持续脊髓麻醉治疗EF为20%的病态肥胖患者的turt: 1例报告。

IF 2.1

Future Science OA Pub Date : 2026-12-01 Epub Date: 2026-03-20 DOI: 10.1080/20565623.2026.2645372

Mustapha Nahle, Mohamad Akhrass, Zakaria Tawbe, Mohamad Ghandour

{"title":"Continuous spinal anesthesia for TURBT in a morbidly obese patient with EF of 20%: a case report.","authors":"Mustapha Nahle, Mohamad Akhrass, Zakaria Tawbe, Mohamad Ghandour","doi":"10.1080/20565623.2026.2645372","DOIUrl":"10.1080/20565623.2026.2645372","url":null,"abstract":"Background: Patients with severely reduced left ventricular function pose major anesthetic challenges. General anesthesia may cause cardiac depression and pulmonary decompensation, while single-shot spinal anesthesia can trigger sudden hypotension. Continuous spinal anesthesia (CSA), however, allows gradual dosing and improved hemodynamic stability in such high-risk patients.Case presentation: We report a 133-kg man with atrial fibrillation, left bundle branch block, global hypokinesia, ejection fraction (EF) of 20%, and prior pulmonary tuberculosis with lung congestion, who underwent transurethral resection of a bladder tumor (TURBT) under CSA. Using the epidural loss-of-resistance technique at L4-L5, a catheter was advanced to 12 cm (6 cm intrathecal). Incremental doses of 1 mg isobaric bupivacaine were administered every 15 minutes to a total of 5 mg. Noninvasive blood pressure was monitored every minute. Baseline BP was 154/98 mmHg and remained stable at 135/90 mmHg intraoperatively, with a heart rate of 65-75 bpm. Adequate anesthesia was achieved without vasopressor use, and recovery was uneventful (Table 1).Conclusion: Incremental CSA with isobaric bupivacaine was safely and effectively used in a morbidly obese patient with low EF undergoing TURBT. The technique maintained hemodynamic stability throughout, suggesting CSA as a viable anesthetic option for endoscopic urologic procedures in patients with compromised cardiac function.","PeriodicalId":12568,"journal":{"name":"Future Science OA","volume":"12 1","pages":"2645372"},"PeriodicalIF":2.1,"publicationDate":"2026-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13007464/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147491131","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Metagenomic next-generation sequencing for pathology-suspected fungal infections at rare anatomical sites: a case series. 新一代宏基因组测序的病理怀疑真菌感染在罕见的解剖部位：一个病例系列。

IF 2.1

Future Science OA Pub Date : 2026-12-01 Epub Date: 2026-05-08 DOI: 10.1080/20565623.2026.2669032

Xizhen Xu, Dong Chen, Nan Luo, Wendi Zhang, Liping Lou

{"title":"Metagenomic next-generation sequencing for pathology-suspected fungal infections at rare anatomical sites: a case series.","authors":"Xizhen Xu, Dong Chen, Nan Luo, Wendi Zhang, Liping Lou","doi":"10.1080/20565623.2026.2669032","DOIUrl":"https://doi.org/10.1080/20565623.2026.2669032","url":null,"abstract":"Objective: Histopathology for suspected fungal infections lacks species-level identification and is prone to morphological mimics. The utility of metagenomic next-generation sequencing (mNGS) at rare anatomical sites is underexplored.Methods: We retrospectively analyzed 10 cases with histopathology suggestive of fungal infection at rare sites (brain, cardiac valve, bone, etc.). All underwent mNGS testing on formalin-fixed paraffin-embedded samples.Results: mNGS detected fungal DNA in 8/10 cases (80%), providing species-level identification (e.g., Cryptococcus, Candida, Fusarium, Rhizopus, Histoplasma). Polymicrobial infections were identified in 70%. mNGS corrected two misdiagnoses: one confirmed neurocysticercosis; another revealed only bacteria in a suspected fungal lesion. Antimicrobial resistance genes (ErmB) were identified in two cases.Conclusion: mNGS enhances diagnostic precision at rare sites by enabling species identification, uncovering polymicrobial infections, and correcting morphological misdiagnoses, supporting targeted therapy.","PeriodicalId":12568,"journal":{"name":"Future Science OA","volume":"12 1","pages":"2669032"},"PeriodicalIF":2.1,"publicationDate":"2026-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147836792","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Mapping ophthalmic research on glycosylation and glycation: a PRISMA-compliant bibliometric and co‑citation analysis. 测绘眼科糖基化和糖基化研究：符合prisma标准的文献计量学和共被引分析。

IF 2.1

Future Science OA Pub Date : 2026-12-01 Epub Date: 2026-04-29 DOI: 10.1080/20565623.2026.2663167

Hongsong Li, Jing Xu, Jiahui Wang, Lina Cheng, Jingjing Fan

{"title":"Mapping ophthalmic research on glycosylation and glycation: a PRISMA-compliant bibliometric and co‑citation analysis.","authors":"Hongsong Li, Jing Xu, Jiahui Wang, Lina Cheng, Jingjing Fan","doi":"10.1080/20565623.2026.2663167","DOIUrl":"10.1080/20565623.2026.2663167","url":null,"abstract":"Background: Enzymatic glycosylation and non-enzymatic glycation contribute significantly to the pathogenesis of major ocular diseases, particularly diabetic retinopathy (DR), age-related macular degeneration (AMD), glaucoma, and cataract. However, the knowledge structure and developmental trajectory of glycosylation-related research in ophthalmology remain unclear.Methods: The literature on the role of enzymatic glycosylation and non-enzymatic glycation modification in ophthalmic diseases from 1997 to 2024 was searched in the core database of Web of Science. Bibliometrics analysis software VOS viewer (version 1.6.20), Citespace (version 6.1.R1), Scimago Graphica (version 6.1.R1), Microsoft Excel 2021.Results: This study analyzed 3,221 publications, all results are available on January 4, 2025. Biochemistry & Molecular Biology was the primary subject area. Research has evolved from early exploration of advanced glycation end products and protein kinase C pathways toward inflammation, biomarker discovery, and risk prediction in specific ocular disorders. Increasing attention has also been directed toward glycosylation-based diagnostic markers and potential therapeutic targets.Conclusion: This bibliometric analysis provides an ophthalmology-centered overview of glycosylation and glycation research, identifying DR as the primary research hub while highlighting emerging translational directions in retinal and other ocular diseases.","PeriodicalId":12568,"journal":{"name":"Future Science OA","volume":"12 1","pages":"2663167"},"PeriodicalIF":2.1,"publicationDate":"2026-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13134405/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147768898","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0