{"title":"Clinical treatment strategy and follow-up of lymphoepithelioma-like carcinoma: a retrospective study.","authors":"Shilong Zhang, Yufu Lin, Zhiyong Li, Zhiming Wang, Rongkui Luo, Xiuping Zhang","doi":"10.1080/20565623.2024.2384878","DOIUrl":"10.1080/20565623.2024.2384878","url":null,"abstract":"<p><p><b>Aim:</b> To investigate the clinical features, diagnosis and treatment of lymphoepithelioma-like carcinoma (LELC).<b>Materials & methods:</b> The clinical data of 114 LELC patients were retrospectively analyzed.<b>Results:</b> Ninety-eight patients (86.0%) were Epstein-Barr virus-encoded small RNA (EBER) positive detected by situ hybridization. A 67.1% (51/76) patients had PD-L1 expression. The 5-year overall survival rate of EBER negative patients was 51.6% while the rate of positive patients was 84.8% (<i>p</i> = 0.015). The 5-year progression free survival rate of EBER negative patients was 40.2% while the rate of positive patients was 70.2% (<i>p</i> = 0.004).<b>Conclusion:</b> The progression of LELC is relatively slow and present a better prognosis. The occurrence of tumor is closely related to Epstein-Barr virus infection and PD-L1 is highly expressed in tumor cells.</p>","PeriodicalId":12568,"journal":{"name":"Future Science OA","volume":"10 1","pages":"2384878"},"PeriodicalIF":2.4,"publicationDate":"2024-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11385158/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142106382","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Formulation and characterization of antibiotic drug loaded aquasome for the topical application.","authors":"Bhuvaneshwari Shanmugam, Umashankar Marakanam Srinivasan","doi":"10.1080/20565623.2024.2367849","DOIUrl":"10.1080/20565623.2024.2367849","url":null,"abstract":"<p><p><b>Aim:</b> This study aimed to develop a topical antibiotic drug delivery system using aquasomes for enhanced treatment of skin and soft tissue infections (SSTIs). <b>Materials & methods:</b> Cephalothin was loaded into aquasomes using a multi-step process and optimized using design of experiment. The aquasomes were characterized for FT-IR, SEM and zeta potential analysis. Entrapment efficacy, <i>In vitro</i> drug release studies, antibacterial assays and stability study was performed to evaluate the efficacy of the formulated aquasomes. <b>Results & conclusion:</b> The formulated cephalothin-loaded aquasomes exhibited stable properties, controlled drug release and significant antibacterial activity against bacteria. This proves that the developed aquasome-based delivery system has the potential for sustained treatment of SSTIs.</p>","PeriodicalId":12568,"journal":{"name":"Future Science OA","volume":"10 1","pages":"2367849"},"PeriodicalIF":2.4,"publicationDate":"2024-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11238917/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141563146","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Future Science OAPub Date : 2024-12-31Epub Date: 2024-11-14DOI: 10.1080/20565623.2024.2419806
Ruqaya Alhaddad, Bassam M Abualsoud, Ibrahim Al-Deeb, Hamdi Nsairat
{"title":"Green synthesized <i>Zingiber officinale</i>-ZnO nanoparticles: anticancer efficacy against 3D breast cancer model.","authors":"Ruqaya Alhaddad, Bassam M Abualsoud, Ibrahim Al-Deeb, Hamdi Nsairat","doi":"10.1080/20565623.2024.2419806","DOIUrl":"10.1080/20565623.2024.2419806","url":null,"abstract":"<p><p><b>Aim:</b> ZnO NPs were prepared via green synthesis utilizing <i>Zingiber Officinale</i>.<b>Methodology:</b> Physical characterization and biological activity were performed against 2D, and 3D spheroids MCF-7 cell lines.<b>Results:</b> The NPs exhibited 188.9, 175.7 and 171.2 nm size with charge of -8.2, -11.7 and -9.7 mV for the 2%, 3% and 4% formulations. XRD confirmed a wurtzite hexagonal phase. FTIR spectra showed Zn-O stretching vibrations. The 2%, 3% and 4% formulations presented IC<sub>50</sub> values of 14.7, 26.2 and 47 μg/ml, respectively, with complete destruction of MCF-7 spheroids. Elevated <i>TNF-α</i> levels suggested an inflammatory-mediated mechanism of action.<b>Conclusion:</b> 2% <i>Zingiber officinale</i>-derived ZnO NPs showed antitumor potential against deserving further mechanistic and <i>in vivo</i> explorations.</p>","PeriodicalId":12568,"journal":{"name":"Future Science OA","volume":"10 1","pages":"2419806"},"PeriodicalIF":2.4,"publicationDate":"2024-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11572278/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142618295","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Future Science OAPub Date : 2024-12-31Epub Date: 2024-11-14DOI: 10.1080/20565623.2024.2418787
Bashar Haruna Gulumbe, Abdulrakib Abdulrahim, Mohammed Bashar Danlami
{"title":"The United Nations' ambitious roadmap against tuberculosis: opportunities, challenges and the imperative of equity.","authors":"Bashar Haruna Gulumbe, Abdulrakib Abdulrahim, Mohammed Bashar Danlami","doi":"10.1080/20565623.2024.2418787","DOIUrl":"10.1080/20565623.2024.2418787","url":null,"abstract":"","PeriodicalId":12568,"journal":{"name":"Future Science OA","volume":"10 1","pages":"2418787"},"PeriodicalIF":2.4,"publicationDate":"2024-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11572144/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142618300","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Future Science OAPub Date : 2024-12-31Epub Date: 2024-08-14DOI: 10.1080/20565623.2024.2380590
Saqib Rauf, Sami Ullah, Muhammad Adil Abid, Asad Ullah, Gullzar Khan, Ainee Urooj Khan, Gulzar Ahmad, Muhammad Ijaz, Sidra Ahmad, Sulaiman Faisal
{"title":"A computational study of gene expression patterns in head and neck squamous cell carcinoma using TCGA data.","authors":"Saqib Rauf, Sami Ullah, Muhammad Adil Abid, Asad Ullah, Gullzar Khan, Ainee Urooj Khan, Gulzar Ahmad, Muhammad Ijaz, Sidra Ahmad, Sulaiman Faisal","doi":"10.1080/20565623.2024.2380590","DOIUrl":"10.1080/20565623.2024.2380590","url":null,"abstract":"<p><p><b>Aim:</b> Head and Neck squamous cell carcinoma (HNSCC) is the second most prevalent cancer in Pakistan. <b>Methods:</b> Gene expression data from TCGA and GETx for normal genes to analyze Differentially Expressed Genes (DEGs). Data was further investigated using the Enrichr tool to perform Gene Ontology (GO). <b>Results:</b> Our analysis identified most significantly differentially expressed genes and explored their established cellular functions as well as their potential involvement in tumor development. We found that the highly expressed Keratin family and <i>S100A9</i> genes. The under-expressed genes <i>KRT4</i> and <i>KRT13</i> provide instructions for the production of keratin proteins. <b>Conclusion:</b> Our study suggests that factors such as poor oral hygiene and smokeless tobacco can result in oral stress and cellular damage and cause cancer.</p>","PeriodicalId":12568,"journal":{"name":"Future Science OA","volume":"10 1","pages":"2380590"},"PeriodicalIF":2.4,"publicationDate":"2024-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11326450/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141975490","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Future Science OAPub Date : 2024-12-31Epub Date: 2024-09-10DOI: 10.1080/20565623.2024.2395244
Luu Hong Dang Nguyen, Ba Linh Tieu, Thi Thanh Nguyen, Nhung Phuong Ha, Giang Thi Huong Nguyen, Thi Hue Hanh Nguyen, Van Hoi Le, Vinh Quang Bui, Lan Hieu Nguyen, Nhu Hiep Pham, Thanh Hai Phan, Huu Thinh Nguyen, Van Song Tran, Chi Viet Bui, Van Kha Vo, Pham Thanh Nhan Nguyen, Ha Huu Phuoc Dang, Van Dung Pham, Van Thinh Cao, Ngoc Minh Phan, Van Tung Nguyen, Thi Le Quyen Le, Thi Lan-Anh Luong, Thi Kim Phuong Doan, Canh Duy Phan, Thanh Xuan Nguyen, Nguyen Tuong Pham, Bao Toan Nguyen, Thi Thu Thuy Pham, Huu Linh Le, Cong Thanh Truong, Thanh Xuan Jasmine, Minh Chi Le, Van Bau Phan, Quang Binh Truong, Thi Huong Ly Tran, Minh Thien Huynh, Tu Quy Tran, Si Tuan Nguyen, Vu Tran, Van Khanh Tran, Huu Nguyen Nguyen, Thi Van Phan, Thi Thanh-Thuy Do, Dinh Kiet Truong, Hoa Giang, Hoai-Nghia Nguyen, Minh-Duy Phan, Le Son Tran, Hung Sang Tang, Duy Sinh Nguyen
{"title":"A consultation and work-up diagnosis protocol for a multicancer early detection test: a case series study.","authors":"Luu Hong Dang Nguyen, Ba Linh Tieu, Thi Thanh Nguyen, Nhung Phuong Ha, Giang Thi Huong Nguyen, Thi Hue Hanh Nguyen, Van Hoi Le, Vinh Quang Bui, Lan Hieu Nguyen, Nhu Hiep Pham, Thanh Hai Phan, Huu Thinh Nguyen, Van Song Tran, Chi Viet Bui, Van Kha Vo, Pham Thanh Nhan Nguyen, Ha Huu Phuoc Dang, Van Dung Pham, Van Thinh Cao, Ngoc Minh Phan, Van Tung Nguyen, Thi Le Quyen Le, Thi Lan-Anh Luong, Thi Kim Phuong Doan, Canh Duy Phan, Thanh Xuan Nguyen, Nguyen Tuong Pham, Bao Toan Nguyen, Thi Thu Thuy Pham, Huu Linh Le, Cong Thanh Truong, Thanh Xuan Jasmine, Minh Chi Le, Van Bau Phan, Quang Binh Truong, Thi Huong Ly Tran, Minh Thien Huynh, Tu Quy Tran, Si Tuan Nguyen, Vu Tran, Van Khanh Tran, Huu Nguyen Nguyen, Thi Van Phan, Thi Thanh-Thuy Do, Dinh Kiet Truong, Hoa Giang, Hoai-Nghia Nguyen, Minh-Duy Phan, Le Son Tran, Hung Sang Tang, Duy Sinh Nguyen","doi":"10.1080/20565623.2024.2395244","DOIUrl":"https://doi.org/10.1080/20565623.2024.2395244","url":null,"abstract":"<p><p>The emergence of multicancer early detection (MCED) tests holds promise for improving early cancer detection and public health outcomes. However, positive MCED test results require confirmation through recommended cancer diagnostic imaging modalities. To address these challenges, we have developed a consultation and work-up protocol for definitive diagnostic results post MCED testing, named SPOT-MAS. Developed through circulating tumor DNA (ctDNA) analysis and in line with professional guidelines and advisory board consensus, this protocol standardizes information to aid general practitioners in accessing, interpreting and managing SPOT-MAS results. Clinical effectiveness is demonstrated through a series of identified cancer cases. Our research indicates that the protocol could empower healthcare professionals to confidently interpret circulating tumor DNA test results for 5 common types of cancer, thereby facilitating the clinical integration of MCED tests.</p>","PeriodicalId":12568,"journal":{"name":"Future Science OA","volume":"10 1","pages":"2395244"},"PeriodicalIF":2.4,"publicationDate":"2024-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11389743/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142283896","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Future Science OAPub Date : 2024-12-31Epub Date: 2024-10-21DOI: 10.1080/20565623.2024.2409609
Orjon Rroji, Carla Mucignat
{"title":"Factors influencing brain recovery from stroke via possible epigenetic changes.","authors":"Orjon Rroji, Carla Mucignat","doi":"10.1080/20565623.2024.2409609","DOIUrl":"10.1080/20565623.2024.2409609","url":null,"abstract":"<p><p><b>Aim:</b> To examine epigenetic changes leading to functional repair after damage to the central motor system.<b>Data sources:</b> A literature search was conducted using medical and health science electronic databases (PubMed, MEDLINE, Scopus) up to July 2023.<b>Study selection:</b> Data were summarized for type of intervention, study design, findings including human and animal studies.<b>Data extraction:</b> Data were extracted and double-checked independently for methodological quality. By means of the influence of environmental (calorie restriction or physical exercise) and other factors, epigenetic instructions were found to increase levels of <i>BDNF</i> and enhance synaptic neurotransmission, possibly leading to larger scale changes in structural and functional assets, which may end up to cognitive and motor repair after stroke.</p>","PeriodicalId":12568,"journal":{"name":"Future Science OA","volume":"10 1","pages":"2409609"},"PeriodicalIF":2.4,"publicationDate":"2024-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11497982/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142462782","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Future Science OAPub Date : 2024-12-31Epub Date: 2024-11-14DOI: 10.1080/20565623.2024.2419779
Mayuko Mizuno, Shinya Imamura, Ai Yoshioka, Ken Washio, Yoshiko Oda, Hiroki Matsuhara, Katsuyo Ohashi-Doi, Atsushi Fukunaga
{"title":"Effect of house dust mite sublingual immunotherapy in patients with adult atopic dermatitis with rhinitis.","authors":"Mayuko Mizuno, Shinya Imamura, Ai Yoshioka, Ken Washio, Yoshiko Oda, Hiroki Matsuhara, Katsuyo Ohashi-Doi, Atsushi Fukunaga","doi":"10.1080/20565623.2024.2419779","DOIUrl":"10.1080/20565623.2024.2419779","url":null,"abstract":"<p><p><b>Aim:</b> Whether house dust mite (HDM) sublingual immunotherapy (SLIT) is effective for the skin symptoms of adult atopic dermatitis (AD) is unclear.<b>Methods:</b> HDM SLIT was added to conventional AD treatment for 10 HDM-sensitized AD patients with rhinitis for 2 years.<b>Results:</b> Seven out of ten enrolled patients completed the study. Eczema Area and Severity Index score was significantly reduced when comparing before treatment and at 24 months follow-up. CD203c ratio in the basophil activation test using HDM extract, skin prick test with HDM extract and <i>Dermatophagoides pteronyssinus/Dermatophagoides farinae</i> specific-IgG4 tended to improve when comparing before treatment and after treatment.<b>Conclusion:</b> HDM SLIT might be a therapeutic option for AD patients with rhinitis who are sensitized to HDM.</p>","PeriodicalId":12568,"journal":{"name":"Future Science OA","volume":"10 1","pages":"2419779"},"PeriodicalIF":2.4,"publicationDate":"2024-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11572311/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142618222","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Future Science OAPub Date : 2024-12-31Epub Date: 2024-08-13DOI: 10.1080/20565623.2024.2381956
Lucy F Costello, Paul G McMenamin, Michelle R Quayle, John F Bertram, Justin W Adams
{"title":"Applying 3D surface scanning technology to create photorealistic three-dimensional printed replicas of human anatomy.","authors":"Lucy F Costello, Paul G McMenamin, Michelle R Quayle, John F Bertram, Justin W Adams","doi":"10.1080/20565623.2024.2381956","DOIUrl":"10.1080/20565623.2024.2381956","url":null,"abstract":"<p><p><b>Aim:</b> To describe advances in 3D data capture and printing that allow photorealistic replicas of human anatomical specimens for education and research, and discuss advantages of current generation printing for replica design and manufacture. <b>Materials & methods:</b> We combine surface scanning and computerized tomography datasets that maximize precise color and geometric capture with ultra violet (UV) curable resin printing to replicate human anatomical specimens. <b>Results:</b> We describe the process for color control, print design and translation of photorealistic 3D meshes into 3D prints in durable resins. <b>Conclusion:</b> Current technologies allow previously unachievable ability to capture and reproduce anatomical specimens, and provide a platform for a new generation of 3D printed teaching materials to be designed and used in anatomy education environments.</p>","PeriodicalId":12568,"journal":{"name":"Future Science OA","volume":"10 1","pages":"2381956"},"PeriodicalIF":2.4,"publicationDate":"2024-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11323862/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141970951","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Future Science OAPub Date : 2024-12-31Epub Date: 2024-10-23DOI: 10.1080/20565623.2024.2413827
Jiajia Zhang, Shenglan Shang, Wanbing Liu, Yangyang Cheng, Fan Hu, Zhengwang Cao, Ling Yue, GuangDa Xiang, Tao Li
{"title":"Effect of aspirin on platelet-rich plasma of diabetes mellitus with lower extremity atherosclerosis.","authors":"Jiajia Zhang, Shenglan Shang, Wanbing Liu, Yangyang Cheng, Fan Hu, Zhengwang Cao, Ling Yue, GuangDa Xiang, Tao Li","doi":"10.1080/20565623.2024.2413827","DOIUrl":"https://doi.org/10.1080/20565623.2024.2413827","url":null,"abstract":"<p><p><b>Aim:</b> Platelet-rich plasma (PRP), enriched with multiple growth factors, is a promising adjunctive therapy for diabetic foot ulcers (DFUs). As a classic anti-platelet drug for diabetic patients, the effects of aspirin on the content of growth factors in PRP remains unclear.<b>Methods:</b> Our study enrolled diabetic patients who were currently taking or not taking aspirin as the research subjects, with healthy volunteers as the control. PRP from these individuals was activated with glucose calcium and thrombin. Growth factors levels in PRP activated supernatant (PRP-AS) and wound healing ability of platelet gel (PG) in the full-thickness skin defect diabetic mouse model were compared.<b>Results:</b> We found the level of growth factors in PRP-AS derived from two groups of diabetic patients were not statistically different, whereas both lower than that from healthy volunteers. Similarly, we found better wound healing ability of PG from healthy volunteers than those from diabetic patients, but no difference between the two groups of diabetic patients in the mouse model.<b>Discussion:</b> Aspirin does not interfere with autologous PRP therapy when using calcium gluconate and thrombin as agonists. However considering the content of growth factors, PRP from healthy volunteers is a preferable option for promoting DFU repair.</p>","PeriodicalId":12568,"journal":{"name":"Future Science OA","volume":"10 1","pages":"2413827"},"PeriodicalIF":2.4,"publicationDate":"2024-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11508953/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142498618","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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