Future Science OA最新文献

{"title":"On the mode of anti-<i>C. albicans</i> activity of a bis(benzoxaborole) analogue of tavaborole.","authors":"Sachin Gadakh, Teresa Szczepińska, Małgorzata Potoczna, Shiho Okitsu-Sakurayama, Piotr Podlasz, Marta Rogalska, Ewa Kaczorowska, Agnieszka Adamczyk-Woźniak, Monika Staniszewska","doi":"10.1080/20565623.2026.2661523","DOIUrl":"10.1080/20565623.2026.2661523","url":null,"abstract":"<p><strong>Background: </strong>Benzoxaboroles showed significant antimicrobial efficacy in the past, warranting further investigation.</p><p><strong>Research design and methods: </strong>Benzoxaboroles were evaluated for their cytotoxicity on Vero E6 and PBMCs, as well as their embryotoxicity in zebrafish embryos. Benzoxaboroles' impact on <i>C. albicans</i> in planktonic and biofilm was assessed. Advanced microscopy provided insights into <i>C. albicans</i> viability, while RNA-seq identified differentially expressed genes, with docking studies underscoring the potential of benzoxaboroles against fungi.</p><p><strong>Results: </strong>Bis(benzoxazole) analog (<b>2</b>) and Tavaborole effectively inhibited <i>C. albicans</i>, decreasing viability to 80% at 64 µg/mL compared to 60% at 16 µg/mL. The biofilm-inhibiting concentration (BIC50) was 2 μg/mL, leading to a 50% reduction in biofilm activity. <b>2</b> exhibited limited morphogenesis, it displayed significantly lower embryotoxicity compared to Tavaborole, with an IC50 greater than 128 μg/mL. <b>2</b> maintained approximately 80% viability of VERO E6 at 64 μg/mL. <b>2</b> reported an IC50 of 2 μg/mL against PBMCs. RNA-seq revealed upregulation of efflux pumps (MDR) and downregulation of inositol-1-phosphate synthase during benzoxazole treatment. Docking studies confirmed interactions with LeuRS.</p><p><strong>Conclusions: </strong>Benzoxaboroles exhibited a similar resistance to azoles, which is associated with increased MDR1 and IDH6 levels. Efflux inhibitors for benzoxaboroles were crucial for treating candidiasis and may inspire future antifungal research.</p>","PeriodicalId":12568,"journal":{"name":"Future Science OA","volume":"12 1","pages":"2661523"},"PeriodicalIF":2.5,"publicationDate":"2026-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13128027/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147768918","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of a multi-component dietary supplement combined with probiotic and omega-3 in individuals with self-reported symptoms of brain fog: an 8-week exploratory study.","authors":"Abeer M Al-Ghananeem, Debbie T Combs Cantrell, Dennis Song, Ammar Jairoun","doi":"10.1080/20565623.2026.2654776","DOIUrl":"10.1080/20565623.2026.2654776","url":null,"abstract":"<p><strong>Aims: </strong>This study used an open-label design, comprising a one-arm eight-weeks-long study, and aimed to evaluate patient satisfaction and the efficacy of a novel dietary supplement composition combined with probiotic and omega-3 to support brain health improvement in 39 participants with confirmed or suspected brain fog caused by trauma, disease, exposure to chemotherapeutics, or similar events.</p><p><strong>Methods: </strong>The primary measure was the change from baseline in survey scores of the Montreal Cognitive Assessment. The secondary outcome was the change from baseline in test scores of the self-reported survey.</p><p><strong>Results: </strong>The results indicated significant improvements across all domains over time (p < 0.0001), with the most substantial changes occurring by Week 8. Repeated-measures analysis of variance showed a significant time effect (F [2.811, 105.4] = 43.09, p < 0.0001), suggesting that cognitive scores progressively improved across the weeks.</p><p><strong>Conclusions: </strong>This exploratory research indicates that the trial kit was feasible, well tolerated, and associated with improvements in exploratory cognitive measures and perceived well-being over an eight-week period, although practice and placebo effects cannot be ruled out. The findings are hypothesis-generating and support further evaluations in randomized, placebo-controlled studies using well-characterized interventions, objective adherence measures, and biomarker-based outcomes.</p>","PeriodicalId":12568,"journal":{"name":"Future Science OA","volume":"12 1","pages":"2654776"},"PeriodicalIF":2.5,"publicationDate":"2026-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13078196/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147653918","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"An experimental study on the role of naloxone in facilitating alcohol metabolism in acute alcohol intoxication rats.","authors":"Ziqi Jin, Yingqi Hu, Xuqi Liu, Yingying Cao, Jiayi Zhang, Runa A, Xiaoxue Wang, Lingyu Zhang, Yongzhi Xue","doi":"10.1080/20565623.2026.2698022","DOIUrl":"10.1080/20565623.2026.2698022","url":null,"abstract":"<p><strong>Objectives: </strong>Naloxone has been used in acute alcohol intoxication (AAI) in China and some other Asian countries. However, the effects of naloxone on alcohol metabolism and its mechanisms are unclear. This study aimed to explore the role of naloxone in facilitating alcohol metabolism.</p><p><strong>Methods: </strong>AAI rat model was established by force-feeding alcohol. The effect of naloxone in facilitating alcohol metabolism was detected using an improved breathalyzer. The open field test (OFT) was also used to observe the behavioral changes in rats.</p><p><strong>Results: </strong>By breathalyzer, naloxone could promote alcohol metabolism in a dose-dependent manner. Naloxone could promote the arousal of rats and increase the spontaneous activity of rats. But Cytochrome P450 2E1 (CYP2E1) protein and mRNA showed no significant changes. Naloxone promotes alcohol metabolism, and the changing trend of blood alcohol concentration shows a good pharmacokinetics-pharmacodynamics (PK-PD) correlation with adrenocorticotropic hormone (ACTH) expression and behavioral changes in rats.</p><p><strong>Conclusion: </strong>We established a method via gas collection bottles to evaluate the metabolic activity of CYP2E1 and alcohol dehydrogenase (ADH) in rats and established a metabolic model reflecting the changes in segmented alcohol concentrations over time. Naloxone could promote alcohol metabolism by promoting arousal, which is beneficial to AAI.</p>","PeriodicalId":12568,"journal":{"name":"Future Science OA","volume":"12 1","pages":"2698022"},"PeriodicalIF":2.5,"publicationDate":"2026-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13348912/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148390489","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Global, regional, and national burden of early-onset and late-onset colorectal cancer, 1990-2021: a comparative analysis for the Global Burden of Disease Study 2021.","authors":"Xiaoping Li, Haipeng Du, Qiuyu Liao, Zhenyu Zhu, Heyuan Niu, Gang Liu","doi":"10.1080/20565623.2026.2677580","DOIUrl":"10.1080/20565623.2026.2677580","url":null,"abstract":"<p><strong>Aims: </strong>Early-onset colorectal cancer (EOCRC) shows a rising global incidence with distinct epidemiological features from late-onset colorectal cancer (LOCRC). This study aimed to compare the epidemiological patterns and temporal trends of EOCRC and LOCRC from 1990 to 2021 based on the Global Burden of Disease (GBD) 2021 dataset.</p><p><strong>Methods: </strong>We analyzed the incidence, prevalence, mortality, and DALYs of EOCRC and LOCRC across 204 countries using the GBD 2021 dataset. Age-standardized rates (ASRs), estimated annual percentage changes (EAPCs), and socio-demographic index (SDI) stratifications were applied. Projections to 2040 were performed using Bayesian modeling.</p><p><strong>Results: </strong>In 2021, LOCRC remained dominant (1.98 million vs. 212,000 cases), but EOCRC exhibited a faster incidence increase (EAPC: 0.37 vs. 0.13). Males were predominant, particularly in cases of EOCRC. Higher SDI was generally associated with higher incidence, though LOCRC declined in regions with SDI >0.85. The rise in EOCRC burden was primarily driven by aging, while population growth drove LOCRC. Projections indicate that ASRs of EOCRC will peak then decrease, whereas LOCRC will continue to rise.</p><p><strong>Conclusions: </strong>LOCRC remains dominant globally, but the rapid increase in EOCRC requires urgent public health action. Age-specific strategies are needed: optimized screening for the elderly to control LOCRC and strengthened risk factor management in young populations to reduce EOCRC.</p>","PeriodicalId":12568,"journal":{"name":"Future Science OA","volume":"12 1","pages":"2677580"},"PeriodicalIF":2.5,"publicationDate":"2026-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13240950/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148156259","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Multi-omics profiling identifies CDK1 as a key mediator of mitosis through the PTN pathway in bladder cancer.","authors":"Li Yang, Jia-Ming Zhang, Yu-Jia Chen, Zhong-Qiong Wei, Mei Zhou, Guo-Qiang Chen, Yu-Xian He, Zhi-Guang Huang, Sheng-Hua Li, Kai-Qiang Tang, Gang Chen","doi":"10.1080/20565623.2026.2696931","DOIUrl":"10.1080/20565623.2026.2696931","url":null,"abstract":"<p><strong>Aims: </strong>This study aimed to characterize cyclin-dependent kinase 1 (CDK1) expression in bladder cancer (BC), elucidate its role in intercellular signaling and mitosis, and identify small-molecule inhibitors targeting CDK1.</p><p><strong>Methods: </strong>RNA sequencing data from multiple databases were integrated, with immunohistochemistry on tissue microarrays validating protein expression. Single-cell RNA sequencing (scRNA-seq), spatial transcriptomics (ST), gene set enrichment analysis (GSEA), and molecular docking with molecular dynamics (MD) simulations were performed.</p><p><strong>Results: </strong>CDK1 mRNA and protein were significantly overexpressed in BC tissues. CDK1 expression correlated with patient age and race. CDK1 was predominantly expressed in epithelial cells and central to pleiotrophin (PTN) pathway-mediated intercellular communication; virtual CDK1 knockout markedly reduced PTN signaling strength. ST confirmed CDK1 enrichment in tumor regions. GSEA linked CDK1 to mitosis and chromosome segregation, and scRNA-seq analyses revealed a PTN-CDK1-mitosis regulatory axis active specifically in epithelial cells. Dinaciclib showed favorable MD stability as a CDK1 inhibitor.</p><p><strong>Conclusion: </strong>CDK1 is significantly overexpressed in BC with good discriminatory ability. Predominantly expressed in BC epithelial cells, CDK1 may be activated by PTN signaling to drive mitosis. MD simulations support Dinaciclib as a promising CDK1-targeting inhibitor.</p>","PeriodicalId":12568,"journal":{"name":"Future Science OA","volume":"12 1","pages":"2696931"},"PeriodicalIF":2.5,"publicationDate":"2026-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13348916/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148387544","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Episiotomy practice and perineal outcomes in low risk vaginal deliveries: comparing a hospital attached birth center and delivery suite in Beirut, Lebanon.","authors":"Charlotte El Hajjar, Mohammed Zaatari, Georges Yared, Manal Dahrouj, Abdullah Kadhim, Ahmad Sabbagh, Issam Hijazi, Julia Ftouny, Christopher Massaad, Kariman Ghazal","doi":"10.1080/20565623.2026.2657529","DOIUrl":"10.1080/20565623.2026.2657529","url":null,"abstract":"<p><p><b>Background:</b> Episiotomy is considered a protective intervention when used selectively rather than routinely. Although current obstetric practice no longer recommends routine episiotomy, data on its use remain limited, particularly in Lebanon.</p><p><p><b>Objective:</b> This study evaluated the prevalence, predictors, and maternal outcomes of episiotomy in low-risk vaginal deliveries and compared its use between a hospital-attached birth center (BC) and a delivery suite (DS).</p><p><p><b>Methods:</b> A retrospective observational study was conducted using data from Rafik Hariri University Hospital (RHUH) BC and DS between January 2024 and September 2025. A total of 333 patients were included. Data were analyzed using SPSS v23. Binary logistic regression identified predictors of episiotomy, while associations with maternal outcomes were assessed using risk ratios and number needed to treat.</p><p><p><b>Results:</b> The episiotomy rate was 28.5%, with no significant difference between BC and DS. Rates were higher among primiparous women. Episiotomy was associated with lower rates of perineal injury overall (NNT = 4 for both parity groups). Among primiparous women, those without episiotomy had significantly higher rates of paraurethral injury (41.2 vs 12.3%, <i>p</i> = 0.011) and first-degree tears (35.3 vs 11.0%). On multivariate logistic regression, independent predictors of episiotomy included primiparity (aOR = 39.18, 95%, CI 18.42-83.33), private patient status (aOR = 21.72, 95%, CI 3.33-141.64), older age (aOR = 0.93, 95% CI: 0.86-0.99), and greater cervical dilation at admission (aOR = 0.74, 95% CI: 0.60-0.91).</p><p><p><b>Conclusion:</b> Episiotomy use varies by case and remains common in low-risk pregnancies, especially among primiparous women. Predictive and preventive factors associated with its use were identified.</p>","PeriodicalId":12568,"journal":{"name":"Future Science OA","volume":"12 1","pages":"2657529"},"PeriodicalIF":2.5,"publicationDate":"2026-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13094207/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147716467","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Potential pathogenesis of <i>Helicobacter pylori</i> strains from Cameroon: seroprevalence of 10 proteins involved in the pathogenesis of <i>Helicobacter pylori</i>-related gastro-duodenal diseases, measured using a new multiplex immunoassay among <i>Helicobacter pylori</i> IgM-positive dyspeptic patients.","authors":"Viny Adrien Fouomene Kenne, Laure Brigitte Kouitcheu Mabeku","doi":"10.1080/20565623.2026.2657525","DOIUrl":"10.1080/20565623.2026.2657525","url":null,"abstract":"<p><strong>Background: </strong>This study aims to evaluate the seroprevalence of <i>Helicobacter pylori</i> (<i>H. pylori)</i> proteins involved in its pathogenicity among <i>H. pylori</i> infected patients.</p><p><strong>Research design and methods: </strong>The analyses were based on 272 serums from <i>H. pylori</i> IgM-positive dyspeptic patients. <i>H. pylori</i> GroEL, FliD, HpaA, gGT, CagA, VacA, NapA, CtkA, HtrA, and HP0231 proteins was detected using multiplex serology method. The detected <i>H. pylori</i> antigens were classified as antigens for colonization, chaperone systems, immunomodulatory factors and toxins/effectors delivery/T4SS-related support factors.</p><p><strong>Results: </strong><i>H. pylori</i> CagA, VacA, FliD, HpaA, GroEL gGT, HtrA, HP0231, CtkA, and NapA proteins were present in 97.1, 77.2, 77.2, 73.2, 61, 34.2, 25.4, 18.8, 11.4, and 9.9%. Antigens involved in colonization, immune response, proteins chaperone, and toxins/effectors and T4SS-related support factors were detected in 81.9%, 19.8%, 70.5%, and 10.6%, respectively. Significant high sensitivity of virulence antigens was recorded among patients aged more than 20 years old, those from west region, male, blood group O, and overweight/obese patients.</p><p><strong>Conclusion: </strong>Our results showed that <i>H. pylori</i> strains in our milieu have a strong ability to colonize the gastric mucosa, but a low carcinogenic potential due to the scarcity of the proteins modulating the detrimental effect of CagA/VacA proteins.</p>","PeriodicalId":12568,"journal":{"name":"Future Science OA","volume":"12 1","pages":"2657525"},"PeriodicalIF":2.5,"publicationDate":"2026-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13094212/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147722536","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ginger-derived nanoparticles targeting NF-κB mediated inflammatory pathways: a systematic review of in vitro and in vivo evidence.","authors":"Ayunita Tri Wirattami, Kusworini Handono, Edi Handoko, Dian Nugrahenny","doi":"10.1080/20565623.2026.2657522","DOIUrl":"10.1080/20565623.2026.2657522","url":null,"abstract":"<p><strong>Background: </strong>Nuclear factor kappa B (NF-κB) is a key regulator of inflammatory responses involved in chronic inflammatory diseases. Bioactive compounds from ginger (<i>Zingiber officinale</i>) inhibit NF-κB signaling but are limited by poor bioavailability. This systematic review aimed to evaluate experimental evidence on the modulatory effects of ginger-derived nanoparticles on NF-κB mediated inflammatory signaling.</p><p><strong>Methods: </strong>Eligible studies included peer-reviewed English preclinical in vitro and in vivo studies assessing ginger-derived nanoparticles targeting NF-κB mediated inflammation; reviews, clinical studies, and non-nanoparticle ginger formulations were excluded. Databases searched were PubMed, ScienceDirect, SpringerLink, the Cochrane Library, Scopus, Web of Science, and Embase (January 2010 to August 2025). Risk of bias was assessed using SYRCLE, SciRAP, and MISEV 2018 tools, and findings were narratively synthesized due to methodological heterogeneity.</p><p><strong>Results: </strong>Seven preclinical studies were included. Ginger-derived nanoparticles consistently suppressed canonical NF-κB signaling by inhibiting IκBα phosphorylation and p65 nuclear translocation, reducing pro-inflammatory cytokines (TNF-α, IL-6, IL-1β), oxidative stress, and tissue inflammation. Evidence was limited by small study numbers, heterogeneous nanoparticle formulations, and reliance on preclinical data, preventing meta-analysis.</p><p><strong>Conclusion: </strong>Ginger-derived nanoparticles represent a promising experimental strategy for modulating inflammatory signaling pathways in preclinical models.</p><p><strong>Protocol registration: </strong>PROSPERO (CRD420261337393).</p>","PeriodicalId":12568,"journal":{"name":"Future Science OA","volume":"12 1","pages":"2657522"},"PeriodicalIF":2.5,"publicationDate":"2026-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13108343/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147768943","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Factors influencing the prediction of obstructive sleep apnea: an observational study from a developing country.","authors":"Noor Al Mortadi, Lina Khasawneh, Basheer Khassawneh, Abedelmalek K Tabnjh, Karem H Alzoubi","doi":"10.1080/20565623.2026.2615969","DOIUrl":"10.1080/20565623.2026.2615969","url":null,"abstract":"<p><strong>Aim: </strong>Upper airway anatomy is important in obstructive sleep apnea (OSA). This study conducted a correlation analysis between the apnea-hypopnea index (AHI) score and upper airway measurements obtained from cone-beam computed tomography (CBCT), arch measurements obtained from diagnostic casts, and subjective data from patients' records, including the Berlin Sleep Questionnaire and Epworth Sleepiness Scale.</p><p><strong>Methods: </strong>Twenty-five subjects with a confirmed diagnosis of OSA via polysomnography with a mean AHI of 25.5 (SD18.5) were enrolled in this study.</p><p><strong>Results: </strong>A significant correlation was found between the AHI score and the following factors: male sex, obesity categories, Berlin questionnaire category, sleep efficiency, and maxillary intermolar width measured between the mesiobuccal cusp tip of the right and left first molars. Airway measurements from CBCT, including anterior cranial base length, facial proportion, and the length of the soft palate in the mid-sagittal plane and the retroglossal area in the axial plane, were significantly correlated with the AHI score.</p><p><strong>Conclusion: </strong>In addition to male gender and obesity, anatomic factors related to upper airway measurements on CBCT are significantly correlated with AHI, indicating upper airway limitations, OSA severity, and aiding early diagnosis.</p>","PeriodicalId":12568,"journal":{"name":"Future Science OA","volume":"12 1","pages":"2615969"},"PeriodicalIF":2.1,"publicationDate":"2026-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12826696/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145997825","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Systematic review of the literature: estimation of the most common gynecological disorders and associated factors among Kazakhstani adolescents.","authors":"Saule Kurbaniyazova, Raushan Nurkhasimova, Ardak Ayazbekov, Saltanat Khudaibergenova, Saltanat Kulbayeva, Dinara Mirzakhmetova, Kenzhegul Ryskeldiyeva","doi":"10.1080/20565623.2025.2599726","DOIUrl":"10.1080/20565623.2025.2599726","url":null,"abstract":"","PeriodicalId":12568,"journal":{"name":"Future Science OA","volume":"12 1","pages":"2599726"},"PeriodicalIF":2.1,"publicationDate":"2026-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12710883/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145742029","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}