Future Science OA最新文献_第2页

Elevated expression of ANAPC1 in lung squamous cell carcinoma: clinical implications and mechanisms. ANAPC1在肺鳞状细胞癌中的表达升高：临床意义和机制

IF 2.4

Future Science OA Pub Date : 2025-12-01 Epub Date: 2025-03-26 DOI: 10.1080/20565623.2025.2482487

Xiao-Song Chen, Feng Chen, Shu-Jia He, Yi-Yang Chen, Bang-Teng Chi, Wan-Ying Huang, Yue Wei, Chun-Yan Zhao, Chang Song, Rong-Quan He, Gang Chen, Jin-Liang Kong, Hui-Ping Lu

{"title":"Elevated expression of ANAPC1 in lung squamous cell carcinoma: clinical implications and mechanisms.","authors":"Xiao-Song Chen, Feng Chen, Shu-Jia He, Yi-Yang Chen, Bang-Teng Chi, Wan-Ying Huang, Yue Wei, Chun-Yan Zhao, Chang Song, Rong-Quan He, Gang Chen, Jin-Liang Kong, Hui-Ping Lu","doi":"10.1080/20565623.2025.2482487","DOIUrl":"10.1080/20565623.2025.2482487","url":null,"abstract":"Aim: To investigate the comprehensive expression levels and possible molecular mechanisms of Anaphase Promoting Complex Subunit 1 (ANAPC1) in lung squamous cell carcinoma (LUSC).Methods: Data from 2,031 samples were combined to evaluate ANAPC1 mRNA levels, and 118 samples were collected for immunohistochemical (IHC) analysis. High-expression co-expressed genes (HECEGs) associated with ANAPC1 were analyzed for signaling pathways. Clinical significance, immune computations, and Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR) validation of ANAPC1's role in LUSC were assessed. Molecular docking evaluated binding affinity with potential therapeutics.Results: ANAPC1 mRNA was significantly upregulated in LUSC (SMD = 1.97, 95% CI [1.26-2.67]). Protein-level analysis confirmed this upregulation (p < 0.001). Most HECEGs associated with ANAPC1 were enriched in cell cycle pathways. Higher ANAPC1 expression correlated with poorer survival in LUSC patients (HR = 1.11, 95% CI: 1-1.49). ANAPC1 expression was higher in males and N1-stage vs. females and N0-stage; lower in grade I vs. II/III. Overexpression reduces immune cell infiltration and immunotherapy effectiveness, while knockdown inhibits cell proliferation. Drug sensitivity and docking analyses identified tenovin-1, carboxyatractyloside, and phycocyanobilin as potential antitumor agents targeting ANAPC1.Conclusion: The elevated expression of ANAPC1 might play a role in LUSC advancement and progression through its participation in cell growth-related pathways.","PeriodicalId":12568,"journal":{"name":"Future Science OA","volume":"11 1","pages":"2482487"},"PeriodicalIF":2.4,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11951694/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143729534","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Modifiable risk factors of dementia in the Indian scenario. 在印度的情况下，痴呆的可改变的危险因素。

IF 2.4

Future Science OA Pub Date : 2025-12-01 Epub Date: 2025-03-24 DOI: 10.1080/20565623.2025.2483132

Ankul Singh S, Lakshmi Chandran, Chitra Vellapandian

引用次数: 0

Reply to the letter to the editor: previous immunological disease can promote neurological complications of SARS-CoV-2 infection, such as VST or GBS. 回复编辑来信：既往免疫性疾病可促进SARS-CoV-2感染的神经系统并发症，如VST或GBS。

IF 2.4

Future Science OA Pub Date : 2025-12-01 Epub Date: 2025-02-17 DOI: 10.1080/20565623.2025.2463851

Shema Ayadi, Hela Jamoussi

引用次数: 0

The association between whole blood viscosity and CHA2DS2-VASc/CHA2DS2-VA scores in patients with atrial fibrillation. 房颤患者全血粘度与CHA2DS2-VASc/CHA2DS2-VA评分的关系

IF 2.4

Future Science OA Pub Date : 2025-12-01 Epub Date: 2025-02-18 DOI: 10.1080/20565623.2025.2467607

Erkan Kahraman, Koray Kalenderoglu

{"title":"The association between whole blood viscosity and CHA2DS2-VASc/CHA2DS2-VA scores in patients with atrial fibrillation.","authors":"Erkan Kahraman, Koray Kalenderoglu","doi":"10.1080/20565623.2025.2467607","DOIUrl":"10.1080/20565623.2025.2467607","url":null,"abstract":"Introduction: CHA2DS2-VASc and CHA2DS2-VA scores are often used to demonstrate thromboembolic risk in nonvalvular atrial fibrillation. Elevated whole blood viscosity is an independent risk factor for ischemic stroke.Objective: This study aimed to ascertain the correlation between whole blood viscosity and CHA2DS2-VASc/CHA2DS2-VA scores.Methods: This study was performed retrospectively in a tertiary cardiac facility, encompassing 150 patients.Results: The study's results demonstrate that whole blood viscosity, concerning both high shear rate and low shear rate variables, are statistically significant in forecasting the likelihood of elevated CHA2DS2-VA and CHA2DS2-VASc scores. (AUC: 0.690, 0.693; p: <0.001; 0.647, 0.665; p: <0.05).Conclusion: Whole blood viscosity had a substantial correlation with the CHA2DS2-VASc/CHA2DS2-VA scores in patients with atrial fibrillation and may be used to evaluate thromboembolism risk, akin to these scores.","PeriodicalId":12568,"journal":{"name":"Future Science OA","volume":"11 1","pages":"2467607"},"PeriodicalIF":2.4,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11845118/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143448798","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Bioanalytical method validation to quantify ketorolac in human vitreous and aqueous via surrogate matrix of human plasma. 通过人血浆替代基质定量人玻璃体和水溶液中酮罗拉酸的生物分析方法验证。

IF 2.4

Future Science OA Pub Date : 2025-12-01 Epub Date: 2025-03-19 DOI: 10.1080/20565623.2025.2476866

Prajita Pandey, Brianna A White, Colin Goswell, Neelanjan Bose, Sara Butterworth Connell, Nicolee Schulze, Jim Nevelos, Ana Najafi, Ramin Najafi, Ryan K Cheu

{"title":"Bioanalytical method validation to quantify ketorolac in human vitreous and aqueous via surrogate matrix of human plasma.","authors":"Prajita Pandey, Brianna A White, Colin Goswell, Neelanjan Bose, Sara Butterworth Connell, Nicolee Schulze, Jim Nevelos, Ana Najafi, Ramin Najafi, Ryan K Cheu","doi":"10.1080/20565623.2025.2476866","DOIUrl":"10.1080/20565623.2025.2476866","url":null,"abstract":"Purpose: Intracameral phenylephrine 1.0%/ketorolac 0.3% (OMIDRIA®) is used during cataract surgery to prevent intraoperative miosis and reduce postoperative pain. Although studied in beagles, no human data exist showing the duration ketorolac remains in the eye postoperatively. A clinical trial measuring ketorolac concentrations in aqueous/vitreous samples necessitated the development of a validation process for acquiring these measurements. Due to limited human aqueous/vitreous humor sample availability, a bioanalytical method was developed and validated to quantify ketorolac levels using human plasma as a surrogate matrix.Methods: The developed process involves extracting ketorolac and its internal standard (ketorolac-d5) from plasma as a surrogate for aqueous and vitreous humor using a protein precipitation sample preparation technique, followed by liquid chromatography-tandem mass spectrometry (LC-MS/MS) analysis.Results: The validated method can be successfully applied for quantitation of ketorolac over a concentration range of 2.5 ng/mL to 5000 ng/mL. The method met the acceptance criteria with respect to selectivity, specificity, precision, accuracy, linearity, dilution integrity, and stability.Conclusions: The validated method can use plasma as a surrogate matrix for quantitation of ketorolac in aqueous and vitreous humor, thereby eliminating the need to procure human vitreous and aqueous samples for validation prior to initiation of a clinical trial.","PeriodicalId":12568,"journal":{"name":"Future Science OA","volume":"11 1","pages":"2476866"},"PeriodicalIF":2.4,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11925105/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143656989","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Diagnosing pulmonary MALT lymphoma: a case of unilateral cystic lesions. 肺MALT淋巴瘤诊断：单侧囊性病变1例。

IF 2.4

Future Science OA Pub Date : 2025-12-01 Epub Date: 2025-04-28 DOI: 10.1080/20565623.2025.2497214

Ping Li, Zhisheng Huang, Yan Qin, Wenjian Liao, Tianxin Xiang

引用次数: 0

Dysadherin expression in prostatic adenocarcinoma and its relationship with E-cadherin and β-catenin. 前列腺腺癌中粘附异常蛋白的表达及其与E-cadherin和β-catenin的关系。

IF 2.4

Future Science OA Pub Date : 2025-12-01 Epub Date: 2025-04-28 DOI: 10.1080/20565623.2025.2494972

Rinë Limani, Labinota Kondirolli, Brikenë Blakaj Gashi, Monika Ulamec, Božo Krušlin

{"title":"Dysadherin expression in prostatic adenocarcinoma and its relationship with E-cadherin and β-catenin.","authors":"Rinë Limani, Labinota Kondirolli, Brikenë Blakaj Gashi, Monika Ulamec, Božo Krušlin","doi":"10.1080/20565623.2025.2494972","DOIUrl":"https://doi.org/10.1080/20565623.2025.2494972","url":null,"abstract":"Background: We analyzed immunoexpression of Dysadherin, E-cadherin and ß-catenin proteins in prostate.Methods: 53 radical prostatectomy specimens were included. Dysadherin, E-cadherin and ß-catenin were evaluated in prostatic adenocarcinoma and in adjacent non-tumorous tissue, and correlated with clinicomorphological features in prostatic adenocarcinoma.Results: We report cytoplasmic/membraneous and nuclear staining for Dysadherin in prostatic tissue. Cytoplasmic/membraneous expression was stronger in prostatic adenocarcinoma when compared to adjacent non-tumorous prostatic tissue (p < 0.001).Dysadherin positively correlated with T status (rho = 0.326, P = 0.017) and Grade Group (rho = 0.278, P = 0.044). We report no correlation with recurrence, surgical margins status, sPSA and N status. E-cadherin was negatively correlated with recurrence (rho = -0.297, P = 0.031), T status (rho = -0.430, P = 0.001), Grade Group (rho = -0.558, P < 0.001) and positive surgical margins (rho = -0.404, P = 0.003). ß-catenin negatively correlated with Grade Group (rho = -0.557, P < 0,001). No correlation was observed between Dysadherin and E-cadherin and Dysadherin and ß-catenin expression.Conclusion: Our results suggest a potential role for Dysadherin in tumor progression. No significant correlation between Dysadherin and E-cadherin or ß-catenin indicates potential independence of Dysadherin in its regulatory role in prostatic adenocarcinoma.","PeriodicalId":12568,"journal":{"name":"Future Science OA","volume":"11 1","pages":"2494972"},"PeriodicalIF":2.4,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12039401/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143965079","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Germline variants analysis of Chinese breast cancer patients reveals numerous alterations in homologous recombination genes. 中国乳腺癌患者的种系变异分析揭示了同源重组基因的许多改变。

IF 2.4

Future Science OA Pub Date : 2025-12-01 Epub Date: 2025-04-01 DOI: 10.1080/20565623.2025.2458432

Zhaoyun Jiang, Bing Xu, Bo Sun, Beibei Yang, Su Lu, Mengjian Li, Juan Zhang, Liqiang Qi, Qixi Wu

{"title":"Germline variants analysis of Chinese breast cancer patients reveals numerous alterations in homologous recombination genes.","authors":"Zhaoyun Jiang, Bing Xu, Bo Sun, Beibei Yang, Su Lu, Mengjian Li, Juan Zhang, Liqiang Qi, Qixi Wu","doi":"10.1080/20565623.2025.2458432","DOIUrl":"10.1080/20565623.2025.2458432","url":null,"abstract":"Purpose: We aimed to identify the pathogenic variants of homologous recombination (HR) genes and analyze the correlation between the pathogenic variants and clinical characteristics in Chinese breast cancer patients.Methods: A cohort of 178 breast cancer patients participated in this study. We assessed genomic alterations using a 23-gene panel, which includes most of the HR-related genes and DNA mismatch repair (MMR) gene, through next-generation sequencing. The pathogenicity of variants was determined based on the American College of Medical Genetics and Genomics standards and guidelines. The correlation between these pathogenic variants and the clinical characteristics of the patients was investigated.Results: 26 pathogenic variants, including one novel suspected pathogenic variant, were detected in 28 (15.7%) patients. These variants occurred in 7 HR-related genes: BRCA1, BRCA2, PALB2, RAD51D, RAD50, BRIP1, and ATM. The frequency of BRCA1 variants was higher in the younger group (8.9%) compared to the older group (2.6%), while the trend was reversed for BRCA2 (3.0% vs. 7.8%). All three patients with the pathogenic variant (p.Lys91fs) in RAD51D were diagnosed with triple-negative breast cancer.Conclusions: HR-gene testing in breast cancer could help to find new suspected pathogenic variants and increase the clinical benefit of multi-gene testing for breast cancer.","PeriodicalId":12568,"journal":{"name":"Future Science OA","volume":"11 1","pages":"2458432"},"PeriodicalIF":2.4,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11970748/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143752200","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Unraveling the anoikis-cancer nexus: a bibliometric analysis of research trends and mechanisms. 揭示嗜酒与癌症的关系：研究趋势和机制的文献计量学分析。

IF 2.4

Future Science OA Pub Date : 2025-12-01 Epub Date: 2025-03-31 DOI: 10.1080/20565623.2025.2484159

Junjie Jiang, Wei Peng, Nianzhe Sun, Deze Zhao, Weifang Cui, Yuwei Lai, Chunfang Zhang, Chaojun Duan, Wei Zeng

{"title":"Unraveling the anoikis-cancer nexus: a bibliometric analysis of research trends and mechanisms.","authors":"Junjie Jiang, Wei Peng, Nianzhe Sun, Deze Zhao, Weifang Cui, Yuwei Lai, Chunfang Zhang, Chaojun Duan, Wei Zeng","doi":"10.1080/20565623.2025.2484159","DOIUrl":"10.1080/20565623.2025.2484159","url":null,"abstract":"Background: Cancer, influenced by genetics and the environment, involves anoikis, a cell death mechanism upon extracellular matrix detachment crucial for metastasis. Understanding this relationship is key for therapy. We analyze cancer and anoikis trends using bibliometrics.Methods: A search was conducted from Web of Science Core, PubMed, Scopus and non-English databases such as the CNKI (inception- 21 December 2024). Data analysis employed Microsoft Excel, VOSviewer, CiteSpace, R software, and the online platform (https://bibliometric.com/).Results: 2510 publications were retrieved, with a significant increase in the last decade. China led, the University of Texas system was productive, and the Oncogene Journal was popular. Breast, and colorectal cancers were frequently studied. Among them, representative tumor-related mechanisms were identified, commonalities such as (EMT, ECM, autophagy) and respective specific mechanisms were summarized.Conclusion: This bibliometric analysis highlights rapid advances in anoikis research in cancer, emphasizing EMT and FAK pathways' translational potential, guiding targeted therapies, and improving cancer treatment outcomes.","PeriodicalId":12568,"journal":{"name":"Future Science OA","volume":"11 1","pages":"2484159"},"PeriodicalIF":2.4,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11959893/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143752206","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Extracellular vesicles in the pathogenesis and future diagnostics of oral squamous cell carcinoma. 细胞外囊泡在口腔鳞状细胞癌发病机制及未来诊断中的作用。

IF 2.4

Future Science OA Pub Date : 2025-12-01 Epub Date: 2025-02-07 DOI: 10.1080/20565623.2025.2461940

Anđela Batur, Ruđer Novak, Grgur Salai, Stela Hrkač, Vesna Ćosić, Lovorka Grgurević

引用次数: 0