Future Science OAPub Date : 2024-12-31Epub Date: 2024-08-13DOI: 10.1080/20565623.2024.2381956
Lucy F Costello, Paul G McMenamin, Michelle R Quayle, John F Bertram, Justin W Adams
{"title":"Applying 3D surface scanning technology to create photorealistic three-dimensional printed replicas of human anatomy.","authors":"Lucy F Costello, Paul G McMenamin, Michelle R Quayle, John F Bertram, Justin W Adams","doi":"10.1080/20565623.2024.2381956","DOIUrl":"10.1080/20565623.2024.2381956","url":null,"abstract":"<p><p><b>Aim:</b> To describe advances in 3D data capture and printing that allow photorealistic replicas of human anatomical specimens for education and research, and discuss advantages of current generation printing for replica design and manufacture. <b>Materials & methods:</b> We combine surface scanning and computerized tomography datasets that maximize precise color and geometric capture with ultra violet (UV) curable resin printing to replicate human anatomical specimens. <b>Results:</b> We describe the process for color control, print design and translation of photorealistic 3D meshes into 3D prints in durable resins. <b>Conclusion:</b> Current technologies allow previously unachievable ability to capture and reproduce anatomical specimens, and provide a platform for a new generation of 3D printed teaching materials to be designed and used in anatomy education environments.</p>","PeriodicalId":12568,"journal":{"name":"Future Science OA","volume":null,"pages":null},"PeriodicalIF":2.4,"publicationDate":"2024-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11323862/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141970951","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"A comprehensive approach for detection of biotin deficiency from dried blood spot samples using liquid chromatography-mass spectrometry.","authors":"Arya Raveendran, Ashutosh Gupta, Leslie E Lewis, Krishnananda Prabhu, Sudheer Moorkoth","doi":"10.1080/20565623.2024.2355038","DOIUrl":"10.1080/20565623.2024.2355038","url":null,"abstract":"<p><p><b>Aim:</b> The aim of the present study is to develop a liquid chromatography-mass spectrometry method to measure two important biomarkers of biotin deficiency from dried blood spot samples for effective management of the disorder. <b>Materials & methods:</b> The method was developed on a liquid chromatography-mass spectrometry system using pentafluorophenyl column employing a mobile phase composition of methanol and water in the isocratic mode. A full validation of the method was performed as per relevant guidelines. <b>Results & conclusion:</b> Correlation between the results of dried blood spot and plasma method was evaluated to determine the interconvertibility of the method. The developed method was successfully applied for establishing the reference ranges for these biomarkers in the population of Udupi, a coastal district of South India.</p>","PeriodicalId":12568,"journal":{"name":"Future Science OA","volume":null,"pages":null},"PeriodicalIF":2.4,"publicationDate":"2024-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11229587/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141497776","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Future Science OAPub Date : 2024-12-31Epub Date: 2024-09-30DOI: 10.1080/20565623.2024.2400797
Muhammad Ishtiaq Obaid, Mohammad Saiem Shahzad, Fakhar Latif, Muhammad Hamza Khan, Moeez Akram, Syed Asad Mehdi Rizvi, Rana Muhammad Umer Nasrullah, Dayab Asad, Muhammad Adil Obaid
{"title":"Relationship between SGLT2 inhibitor use and specific cancer types: a systematic review and meta-analysis.","authors":"Muhammad Ishtiaq Obaid, Mohammad Saiem Shahzad, Fakhar Latif, Muhammad Hamza Khan, Moeez Akram, Syed Asad Mehdi Rizvi, Rana Muhammad Umer Nasrullah, Dayab Asad, Muhammad Adil Obaid","doi":"10.1080/20565623.2024.2400797","DOIUrl":"10.1080/20565623.2024.2400797","url":null,"abstract":"<p><p><b>Aim:</b> The study aimed to explore the incidence of cancer as an adverse event to SGLT2 inhibitors (SGLT2i) use in Type 2 diabetes.<b>Materials & methods:</b> The study followed PRISMA guidelines to pool RCTs conforming the inclusion criteria. Random effects model was used to pool risk ratios.<b>Results & conclusion:</b> After reviewing 19 studies, the analysis suggested a possible increased risk of reproductive, breast, thyroid, hematologic/lymphatic, urinary, skin and skeletal cancers with SGLT2i use. Conversely, lower incidences of respiratory and cardiovascular cancers were noted. However, these associations lacked statistical significance. Caution is advised in using SGLT2i due to potential cancer risks, especially in diabetic patients prone to cancer. More RCTs are essential due to limited research in this area.</p>","PeriodicalId":12568,"journal":{"name":"Future Science OA","volume":null,"pages":null},"PeriodicalIF":2.4,"publicationDate":"2024-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11444652/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142344873","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Promising approach for targeting ROBO1 with CAR NK cells to combat ovarian cancer primary tumor cells and organoids.","authors":"Yan Zhu, Luanhong Wang, Biyu Jiang, Yini Wang, Qing Wu, Sihua Hong, Xiaojing Wang, Yuancheng Li, Tian Guan, Haoyu Zeng, Congzhu Li","doi":"10.2144/fsoa-2023-0135","DOIUrl":"10.2144/fsoa-2023-0135","url":null,"abstract":"<p><p><b>Aim:</b> This study aimed to explore using peripheral blood mononuclear cell (PBMC)-derived chimeric antigen receptor (CAR) NK cells targeting ROBO1 as a personalized medicine approach for ovarian cancer. <b>Methods:</b> A two-step strategy generated ROBO1-targeted CAR NK cells from PBMCs of ovarian cancer patients. Efficacy was evaluated using xCELLigence RTCA, CCK-8 and Live/Dead fluorescence assays. <b>Results:</b> ROBO1-NK cells exhibited higher efficiency in eradicating primary ovarian cancer cells and lysing ovarian tumor organoids compared with primary NK cells without ROBO1-CAR modification. <b>Conclusion:</b> These findings highlight the potential of developing ROBO1-targeted CAR-NK cells from patients' PBMCs as a personalized treatment option for ovarian cancer.</p>","PeriodicalId":12568,"journal":{"name":"Future Science OA","volume":null,"pages":null},"PeriodicalIF":2.4,"publicationDate":"2024-07-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11290772/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141787786","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Future Science OAPub Date : 2024-06-06eCollection Date: 2024-01-01DOI: 10.2144/fsoa-2023-0144
Humaira Jabbar, Tooba Noor, Muhammad A Obaid, Areej Shakil, Muhammad I Obaid, Syeda I Aaqil, Usama Aa Memon, Zoha Mohsin
{"title":"Analysis of attitudes and practices toward gastroesophageal reflux disease among the general population of Pakistan.","authors":"Humaira Jabbar, Tooba Noor, Muhammad A Obaid, Areej Shakil, Muhammad I Obaid, Syeda I Aaqil, Usama Aa Memon, Zoha Mohsin","doi":"10.2144/fsoa-2023-0144","DOIUrl":"10.2144/fsoa-2023-0144","url":null,"abstract":"<p><p><b>Aim:</b> Gastro-esophageal reflux disease (GERD) is a growing health concern. <b>Methods:</b> In this cross-sectional study, participants' knowledge, attitude and practice toward GERD were assessed using a questionnaire. <b>Results:</b> In our study of 411 participants, 92.5% knew about GERD. Correctly identified risk factors were smoking (62.3%), fatty food (84.2%), spicy food (91.2%) and meal timing (80.8%). Identified symptoms were burning sensation (92.2%) and regurgitation (81.0%). 43.6% of participants were unaware of GERD's complications. Only 46.2% would seek medical advice for feeling full after eating, but 85% would for severe symptoms. 88.7 and 86.8% of participants showed willingness to amend diet and lifestyle. <b>Conclusion:</b> General population has knowledge regarding GERD and its risk factors but poor attitude and practices toward the condition.</p>","PeriodicalId":12568,"journal":{"name":"Future Science OA","volume":null,"pages":null},"PeriodicalIF":2.5,"publicationDate":"2024-06-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11160512/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141295907","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Future Science OAPub Date : 2024-05-24eCollection Date: 2024-01-01DOI: 10.2144/fsoa-2023-0227
Mubashir Zafar, Tafazzul Hyder Zaidi, Nadira Hyder Zaidi, Muhammad Waqas Nisar Ahmed, Mahjabeen Shah, Umm E Habiba, Marrium Sultan Dar, Noor Ul Ain, Fatima Shahid, Hiba Hamid Meer
{"title":"Assessment of lifestyle changes in combating the COVID-19 pandemic among people of Karachi, Pakistan.","authors":"Mubashir Zafar, Tafazzul Hyder Zaidi, Nadira Hyder Zaidi, Muhammad Waqas Nisar Ahmed, Mahjabeen Shah, Umm E Habiba, Marrium Sultan Dar, Noor Ul Ain, Fatima Shahid, Hiba Hamid Meer","doi":"10.2144/fsoa-2023-0227","DOIUrl":"10.2144/fsoa-2023-0227","url":null,"abstract":"<p><p><b>Aim:</b> COVID-19 arose as a pandemic that wreaked havoc all over the world. Study determines lifestyle changes adopted by people of Karachi in response to COVID-19 pandemic. <b>Methods:</b> This was the cross-sectional study and carried out at public sector hospital and 218 participants were selected through random sampling method. <b>Results:</b> Lifestyle changes a statistically significant difference in nutrition (p = 0.000), physical activity (p = 0.000), workout (p = 0.000), smoking (p = 0.000), sleep hours (p = 0.000), and supplements (p = 0.000) before and during lockdown. Face masks were utilized by 38% of individuals, gloves by 19%, and social isolation was observed by 26%. 11% of participants did not follow any protocols. <b>Conclusion:</b> Study found significant differences in lifestyle habits such as diet, sleep, smoking and physical activity.</p>","PeriodicalId":12568,"journal":{"name":"Future Science OA","volume":null,"pages":null},"PeriodicalIF":2.5,"publicationDate":"2024-05-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11152586/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141261543","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Future Science OAPub Date : 2024-05-24eCollection Date: 2024-01-01DOI: 10.2144/fsoa-2023-0174
Mouna Medhioub, Becem Trabelsi, Amal Khsiba, Mohamed Saied, Moufida Mahmoudi, Asma Ben Mohamed, Manel Yacoubi, Lamine Hamzaoui, Mechaal Ben Ali
{"title":"Air embolism complicating endoscopic retrograde cholangiopancreatography.","authors":"Mouna Medhioub, Becem Trabelsi, Amal Khsiba, Mohamed Saied, Moufida Mahmoudi, Asma Ben Mohamed, Manel Yacoubi, Lamine Hamzaoui, Mechaal Ben Ali","doi":"10.2144/fsoa-2023-0174","DOIUrl":"10.2144/fsoa-2023-0174","url":null,"abstract":"<p><p><b>Aim:</b> Venous air embolism is a rare but potentially life threatening complication of endoscopic retrograde cholangiopancreatography. Diagnosis is difficult because of the lack of specific signs or symptoms. <b>Case:</b> A 62-year-old man underwent endoscopic retrograde cholangiopancreatography for choledocholithiasis. A cardiovascular collapse occurred during the procedure. The echocardiography showed air within the right ventricle. Aspiration of air from the right ventricle was done and saved the patient's life. <b>Conclusion:</b> We highlight through this case that increased awareness is essential for prompt recognition of the air embolism to allow life-saving therapy.</p>","PeriodicalId":12568,"journal":{"name":"Future Science OA","volume":null,"pages":null},"PeriodicalIF":2.5,"publicationDate":"2024-05-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11152584/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141261488","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Future Science OAPub Date : 2024-05-24eCollection Date: 2024-01-01DOI: 10.2144/fsoa-2023-0198
Hend Smaoui, Lassaad Chtourou, Dana Jallouli, Samar Ben Jemaa, Iheb Karaa, Mouna Boudabbous, Manel Moalla, Hela Gdoura, Leila Mnif, Ali Amouri, Rim Akrout, Fatma Ayadi, Sofien Baklouti, Nabil Tahri
{"title":"Effect of long-term proton pump inhibitors on phosphocalcium metabolism and bone mineral density.","authors":"Hend Smaoui, Lassaad Chtourou, Dana Jallouli, Samar Ben Jemaa, Iheb Karaa, Mouna Boudabbous, Manel Moalla, Hela Gdoura, Leila Mnif, Ali Amouri, Rim Akrout, Fatma Ayadi, Sofien Baklouti, Nabil Tahri","doi":"10.2144/fsoa-2023-0198","DOIUrl":"10.2144/fsoa-2023-0198","url":null,"abstract":"<p><p><b>Aim:</b> Although Proton pump inhibitors (PPIs) are well-tolerated, their long-term use may be associated with decreased bone mass. <b>Methods:</b> This is a case-control study including patients treated with PPIs (>1 year) and control subjects who have not received PPIs treatment. <b>Results:</b> A total of 90 patients and 90 matched controls were included. PPIs use was associated with hypocalcemia and hypomagnesemia. Vitamin D3 deficiency and hyperparathyroidism were associated with PPIs use. Long-term PPIs use was significantly associated with decreased bone density. Risk factors of decreased bone mineral density (BMD) included age >50 years, menopause, lack of sun exposure, double PPIs dose, daily intake, post-meal intake and association with a mucoprotective agent. <b>Conclusion:</b> Our results highlight the risk of decreased BMD in patients on long-term PPIs treatment.</p>","PeriodicalId":12568,"journal":{"name":"Future Science OA","volume":null,"pages":null},"PeriodicalIF":2.5,"publicationDate":"2024-05-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11152587/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141261524","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Protective potential of mesenchymal stem cells against COVID-19 during pregnancy.","authors":"Sihem Aouabdi, Doaa Aboalola, Samer Zakari, Suliman Alwafi, Taoufik Nedjadi, Rawiah Alsiary","doi":"10.2144/fsoa-2023-0179","DOIUrl":"10.2144/fsoa-2023-0179","url":null,"abstract":"<p><p>SARS-CoV-2 causes COVID-19. COVID-19 has led to severe clinical illnesses and an unprecedented death toll. The virus induces immune inflammatory responses specifically cytokine storm in lungs. Several published reports indicated that pregnant females are less likely to develop severe symptoms compared with non-pregnant. Putative protective role of maternal blood circulating fetal mesenchymal stem cells (MSCs) has emerged and have been put forward as an explanation to alleviated symptoms. MSCs with immune-modulatory, anti-inflammatory and anti-viral roles, hold great potential for the treatment of COVID-19. MSCs could be an alternative to treat infections resulting from the SARS-CoV-2 and potential future outbreaks. This review focuses on the MSCs putative protective roles against COVID-19 in pregnant females.</p>","PeriodicalId":12568,"journal":{"name":"Future Science OA","volume":null,"pages":null},"PeriodicalIF":2.5,"publicationDate":"2024-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11149780/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141247662","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Future Science OAPub Date : 2024-05-20eCollection Date: 2024-01-01DOI: 10.2144/fsoa-2023-0123
Xu XiaoMing, Chen Yan, Gu JiaMing, Liang LiTao, Zhang LiJuan, Song Ying, Yuan Lu, Song Qian, Dong Jian
{"title":"Human umbilical cord mesenchymal stem cells combined with porcine small intestinal submucosa promote the healing of full-thickness skin injury in SD rats.","authors":"Xu XiaoMing, Chen Yan, Gu JiaMing, Liang LiTao, Zhang LiJuan, Song Ying, Yuan Lu, Song Qian, Dong Jian","doi":"10.2144/fsoa-2023-0123","DOIUrl":"10.2144/fsoa-2023-0123","url":null,"abstract":"<p><p><b>Aim:</b> To assess the therapeutic potential of human umbilical cord mesenchymal stem cells (hUCMSCs) combined with porcine small intestinal submucosa (SIS) on full-thickness skin injuries in rats. <b>Methods:</b> We established full-thickness skin injury models in Sprague-Dawley rats, dividing them into blank control, SIS, hUCMSCs and hUCMSCs combined with SIS. We monitored wound healing, scores and area, and analyzed inflammatory cells, microvessel density and collagen fibers after 12 days. <b>Results:</b> The blank group showed no healing, forming a scar of 0.6 × 0.5 cm<sup>2</sup>, while SIS and hUCMSCs groups exhibited incomplete healing with 0.4 × 0.5 cm<sup>2</sup> scabs. Wound healing was significantly better in the hUCMSCs combined with the SIS group. <b>Conclusion:</b> Local application of hUCMSCs combined with SIS enhances full-thickness skin injury wound healing in rats.</p>","PeriodicalId":12568,"journal":{"name":"Future Science OA","volume":null,"pages":null},"PeriodicalIF":2.5,"publicationDate":"2024-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11137796/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141179426","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}