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引用次数: 0
摘要
背景：癌症受遗传和环境的影响，涉及细胞凋亡，细胞外基质脱落的细胞死亡机制，对转移至关重要。理解这种关系是治疗的关键。我们使用文献计量学分析癌症和疾病的趋势。方法：检索Web of Science Core、PubMed、Scopus和CNKI等非英文数据库（成立- 2024年12月21日）。数据分析采用Microsoft Excel、VOSviewer、CiteSpace、R软件和在线平台（https://bibliometric.com/）.Results)，共检索到2510篇出版物，近十年来有显著增长。中国带头，德克萨斯大学系统卓有成效，《致癌基因杂志》广受欢迎。乳腺癌和结直肠癌经常被研究。其中，确定了具有代表性的肿瘤相关机制，总结了EMT、ECM、自噬等共性及各自的具体机制。结论：这一文献计量学分析凸显了anoikis在癌症研究中的快速进展，强调了EMT和FAK通路的转化潜力，指导了靶向治疗，改善了癌症治疗结果。
Unraveling the anoikis-cancer nexus: a bibliometric analysis of research trends and mechanisms.
Background: Cancer, influenced by genetics and the environment, involves anoikis, a cell death mechanism upon extracellular matrix detachment crucial for metastasis. Understanding this relationship is key for therapy. We analyze cancer and anoikis trends using bibliometrics.
Methods: A search was conducted from Web of Science Core, PubMed, Scopus and non-English databases such as the CNKI (inception- 21 December 2024). Data analysis employed Microsoft Excel, VOSviewer, CiteSpace, R software, and the online platform (https://bibliometric.com/).
Results: 2510 publications were retrieved, with a significant increase in the last decade. China led, the University of Texas system was productive, and the Oncogene Journal was popular. Breast, and colorectal cancers were frequently studied. Among them, representative tumor-related mechanisms were identified, commonalities such as (EMT, ECM, autophagy) and respective specific mechanisms were summarized.
Conclusion: This bibliometric analysis highlights rapid advances in anoikis research in cancer, emphasizing EMT and FAK pathways' translational potential, guiding targeted therapies, and improving cancer treatment outcomes.
期刊介绍：
Future Science OA is an online, open access, peer-reviewed title from the Future Science Group. The journal covers research and discussion related to advances in biotechnology, medicine and health. The journal embraces the importance of publishing all good-quality research with the potential to further the progress of research in these fields. All original research articles will be considered that are within the journal''s scope, and have been conducted with scientific rigour and research integrity. The journal also features review articles, editorials and perspectives, providing readers with a leading source of commentary and analysis. Submissions of the following article types will be considered: -Research articles -Preliminary communications -Short communications -Methodologies -Trial design articles -Trial results (including early-phase and negative studies) -Reviews -Perspectives -Commentaries
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