Future Science OA最新文献_第3页

Effect of house dust mite sublingual immunotherapy in patients with adult atopic dermatitis with rhinitis. 屋尘螨舌下免疫疗法对伴有鼻炎的成人特应性皮炎患者的疗效。

IF 2.4

Future Science OA Pub Date : 2024-12-31 Epub Date: 2024-11-14 DOI: 10.1080/20565623.2024.2419779

Mayuko Mizuno, Shinya Imamura, Ai Yoshioka, Ken Washio, Yoshiko Oda, Hiroki Matsuhara, Katsuyo Ohashi-Doi, Atsushi Fukunaga

引用次数: 0

Applying 3D surface scanning technology to create photorealistic three-dimensional printed replicas of human anatomy. 应用三维表面扫描技术制作逼真的人体解剖三维打印复制品。

IF 2.4

Future Science OA Pub Date : 2024-12-31 Epub Date: 2024-08-13 DOI: 10.1080/20565623.2024.2381956

Lucy F Costello, Paul G McMenamin, Michelle R Quayle, John F Bertram, Justin W Adams

引用次数: 0

Pure Leydig cell tumor of the ovary: a rare presentation of a rare entity in a pregnant patient. 卵巢纯性亮德氏细胞瘤：一名孕妇罕见的罕见病例。

IF 2.4

Future Science OA Pub Date : 2024-12-31 Epub Date: 2024-11-21 DOI: 10.1080/20565623.2024.2424144

Anwar Rjoop, Alia Almohtaseb, Daoud O Al Aruri, Dina Hyari, Mohammad Abu Shugaer

引用次数: 0

Effect of aspirin on platelet-rich plasma of diabetes mellitus with lower extremity atherosclerosis. 阿司匹林对下肢动脉粥样硬化糖尿病患者血小板丰富血浆的影响

IF 2.4

Future Science OA Pub Date : 2024-12-31 Epub Date: 2024-10-23 DOI: 10.1080/20565623.2024.2413827

Jiajia Zhang, Shenglan Shang, Wanbing Liu, Yangyang Cheng, Fan Hu, Zhengwang Cao, Ling Yue, GuangDa Xiang, Tao Li

{"title":"Effect of aspirin on platelet-rich plasma of diabetes mellitus with lower extremity atherosclerosis.","authors":"Jiajia Zhang, Shenglan Shang, Wanbing Liu, Yangyang Cheng, Fan Hu, Zhengwang Cao, Ling Yue, GuangDa Xiang, Tao Li","doi":"10.1080/20565623.2024.2413827","DOIUrl":"https://doi.org/10.1080/20565623.2024.2413827","url":null,"abstract":"Aim: Platelet-rich plasma (PRP), enriched with multiple growth factors, is a promising adjunctive therapy for diabetic foot ulcers (DFUs). As a classic anti-platelet drug for diabetic patients, the effects of aspirin on the content of growth factors in PRP remains unclear.Methods: Our study enrolled diabetic patients who were currently taking or not taking aspirin as the research subjects, with healthy volunteers as the control. PRP from these individuals was activated with glucose calcium and thrombin. Growth factors levels in PRP activated supernatant (PRP-AS) and wound healing ability of platelet gel (PG) in the full-thickness skin defect diabetic mouse model were compared.Results: We found the level of growth factors in PRP-AS derived from two groups of diabetic patients were not statistically different, whereas both lower than that from healthy volunteers. Similarly, we found better wound healing ability of PG from healthy volunteers than those from diabetic patients, but no difference between the two groups of diabetic patients in the mouse model.Discussion: Aspirin does not interfere with autologous PRP therapy when using calcium gluconate and thrombin as agonists. However considering the content of growth factors, PRP from healthy volunteers is a preferable option for promoting DFU repair.","PeriodicalId":12568,"journal":{"name":"Future Science OA","volume":"10 1","pages":"2413827"},"PeriodicalIF":2.4,"publicationDate":"2024-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11508953/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142498618","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Challenging case of disseminated tuberculosis in an immunocompetent adult. 一个免疫功能正常的成年人感染播散性结核病的棘手病例。

IF 2.4

Future Science OA Pub Date : 2024-12-31 Epub Date: 2024-11-14 DOI: 10.1080/20565623.2024.2419392

Narjes Abid, Ella Nemsi, Siwar Sbaihi, Rahma Ayadi, Manel Loukil, Nada Gader, Khaoula Hemissi, Hedia Ghrairi

{"title":"Challenging case of disseminated tuberculosis in an immunocompetent adult.","authors":"Narjes Abid, Ella Nemsi, Siwar Sbaihi, Rahma Ayadi, Manel Loukil, Nada Gader, Khaoula Hemissi, Hedia Ghrairi","doi":"10.1080/20565623.2024.2419392","DOIUrl":"10.1080/20565623.2024.2419392","url":null,"abstract":"Disseminated tuberculosis (TB) is a TB infection involving two or more noncontiguous sites. It is a challenging medical care due to its misleading presentation. Although it is associated with immunodepression, rare cases have been described in immunocompetent patients.We report the case of a 27-year-old immunocompetent man who presented with an altered general condition and dyspnea. Chest computed tomography (CT) revealed pulmonary masses and mediastinal lymphadenopathy. Sputum smear microscopy for acid-fast bacilli was negative. Scannoguided transparietal lung biopsy was performed twice with inflammatory tissue in histological study. A surgical lung biopsy was then made. The histopathology report confirmed TB involving lung, pleura and lymph nodes. A few days after antituberculosis therapy was started, the patient developed psychomotor slowing related to quadriportal hydrocephalus. He benefited from ventriculoperitoneal bypass. Polymerase chain reaction for detection of Mycobacterium TB was positive in cerebrospinal fluid.In conclusion: The diagnosis of disseminated TB is challenging owing to its non-specific clinical and radiological presentation and the frequent negativity of biological fluids for tubercle bacilli. Molecular biology should always be considered in front of lingering symptoms, particularly in endemic areas, given their speed and sensitivity, thus avoiding invasive diagnostic procedures, as was the case with our patient.","PeriodicalId":12568,"journal":{"name":"Future Science OA","volume":"10 1","pages":"2419392"},"PeriodicalIF":2.4,"publicationDate":"2024-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11572283/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142618221","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Sociodemographic factors are related to hair sample collection in economically marginalized families. 社会人口因素与经济边缘化家庭的头发样本采集有关。

IF 2.4

Future Science OA Pub Date : 2024-12-31 Epub Date: 2024-11-14 DOI: 10.1080/20565623.2024.2420561

Jiying Ling, Dalton Goodwin, Charles Given

{"title":"Sociodemographic factors are related to hair sample collection in economically marginalized families.","authors":"Jiying Ling, Dalton Goodwin, Charles Given","doi":"10.1080/20565623.2024.2420561","DOIUrl":"10.1080/20565623.2024.2420561","url":null,"abstract":"Aim: Limited research has explored factors influencing participants' decisions to consent to and complete hair sample collection. This study examined the relationships of sociodemographics, perceived stress and coping with hair sample collection among children aged 3-5 years and parents.Research design & methods: Data were analyzed from 188 parent-child dyads. Among these, 78% of parents provided consent to hair sample collection. Hair samples were collected from 81% children and 68% parents.Results: Parents who provided consent reported higher levels of stress and used more avoidant coping strategies compared with those who did not. Parents who provided a hair sample engaged in less problem-focused coping. Children who were girls, non-Hispanic and White had higher odds of completing hair sample collection. Additionally, children were more likely to complete hair sample collection if their parents were married, employed full-time, or had an annual family income of ≥$20,000. Pregnant women and full-time employed parents also had higher odds of completing hair sample collection.Conclusion: The study identified important sociodemographic factors that may influence hair sample collection in research. To improve participation, tailored approaches such as at-home self-collection, sensitive hair cutting approaches to maintain participants' hair style, and addressing participants' unique barriers are recommended.","PeriodicalId":12568,"journal":{"name":"Future Science OA","volume":"10 1","pages":"2420561"},"PeriodicalIF":2.4,"publicationDate":"2024-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11572132/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142618299","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A comprehensive approach for detection of biotin deficiency from dried blood spot samples using liquid chromatography-mass spectrometry. 利用液相色谱-质谱法从干血斑样本中检测生物素缺乏症的综合方法。

IF 2.4

Future Science OA Pub Date : 2024-12-31 Epub Date: 2024-07-04 DOI: 10.1080/20565623.2024.2355038

Arya Raveendran, Ashutosh Gupta, Leslie E Lewis, Krishnananda Prabhu, Sudheer Moorkoth

引用次数: 0

Thioctic acid shield against lipopolysaccharide depression and endoplasmic reticulum stress: GR7M/Homer/ATF6 signaling. 硫辛酸可抵御脂多糖抑制和内质网应激：GR7M/Homer/ATF6信号传导。

IF 2.4

Future Science OA Pub Date : 2024-12-31 Epub Date: 2024-11-25 DOI: 10.1080/20565623.2024.2422791

Mai O Kadry, Rehab M Abdel-Megeed

{"title":"Thioctic acid shield against lipopolysaccharide depression and endoplasmic reticulum stress: GR7M/Homer/ATF6 signaling.","authors":"Mai O Kadry, Rehab M Abdel-Megeed","doi":"10.1080/20565623.2024.2422791","DOIUrl":"10.1080/20565623.2024.2422791","url":null,"abstract":"Aim: Endoplasmic reticulum stress triggers neuronal unfolded protein accumulation, contributing to the pathophysiology of depression psychiatric illnesses.Materials & methods: The brain-derived neurotrophic factor (BDNF), metabotropic glutamate receptor type 7 (GRM7), phosphoinisitol kinase-3 (PIK3), serine/threonine kinase 1 (AKT) and Homer1 may afford an important signaling pathways in LPS induced depression rat model. Herein, thioctic acid, Burdock and propolis therapeutic index on lipopolysaccharide (LPS)-induced depression was monitored. BDNF/PI3K/GR7M/ATF6/CHOP/XBP/AKT/Homer-1 signaling pathways also opened a novel avenue in the integration of synaptic neurotransmission.Results: The aforementioned treatments elevated GR7M/BDNF/GABA gene expression meanwhile decreased reactive oxygen species generation (Malondialdehyde/glutathione reductase/Total antioxidant capacity) and reduced the expression of ATF6/CHOP/PI3K/AKT/XBP/Homer-1 post LPS elevation.Conclusion: Thioctic acid, propolis and Burdock are prospective therapeutic agents via GRM7/BDNF/AKT/PI3K/ATF6/XBP/homer -1 signaling pathways in LPS-induced depression.","PeriodicalId":12568,"journal":{"name":"Future Science OA","volume":"10 1","pages":"2422791"},"PeriodicalIF":2.4,"publicationDate":"2024-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11591480/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142709861","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Association between hypo-osmotic swelling test-induced tail swelling patterns and sperm quality. 低渗透膨胀试验诱导的尾部膨胀模式与精子质量之间的关系。

IF 2.4

Future Science OA Pub Date : 2024-12-31 Epub Date: 2024-10-17 DOI: 10.1080/20565623.2024.2410696

Salima Daoud, Olfa Abdelkefi, Afifa Sellami, Azza Bensalem, Nozha Chakroun, Tarek Rebai

{"title":"Association between hypo-osmotic swelling test-induced tail swelling patterns and sperm quality.","authors":"Salima Daoud, Olfa Abdelkefi, Afifa Sellami, Azza Bensalem, Nozha Chakroun, Tarek Rebai","doi":"10.1080/20565623.2024.2410696","DOIUrl":"https://doi.org/10.1080/20565623.2024.2410696","url":null,"abstract":"Aim: The current sperm selection procedure for intracytoplasmic sperm injection has limited ability to detect structural and functional abnormalities of the spermatozoa. The aim of this study was to investigate whether the degree of sperm tail swelling observed during hypo-osmotic swelling test (HOST) may predict sperm quality.Materials & methods: Sixty semen samples were collected from men investigated for couple infertility. For each sample, sperm parameters, HOST and sperm chromatin status were evaluated. The relationship between the different HOST-induced tail swelling patterns ('a' to 'g') and sperm quality was evaluated.Results: The HOST significantly correlated with higher sperm motility and vitality, and with better morphology and nuclear quality. The HOST grades 'b' and 'c' were associated with better motility (p < 0.05 and p < 0.01, respectively) and morphology (grade 'b', p < 0.001). While grade 'd' was associated with better motility and count (p < 0.05).Conclusion: Our results show that the pattern of sperm tail swelling is linked to sperm functional integrity. HOST grades 'b' and 'd' were associated with better sperm quality, suggesting their preferential use during routine sperm selection for intracytoplasmic sperm injection.","PeriodicalId":12568,"journal":{"name":"Future Science OA","volume":"10 1","pages":"2410696"},"PeriodicalIF":2.4,"publicationDate":"2024-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11487947/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142462780","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

CD4+ T-cell transcription factors predict phenoconversion in idiopathic rapid eye movement sleep behavior disorder. CD4+ T细胞转录因子可预测特发性快速眼动睡眠行为障碍的表型转换。

IF 2.4

Future Science OA Pub Date : 2024-12-31 Epub Date: 2024-11-14 DOI: 10.1080/20565623.2024.2418821

Monica Pinoli, Michele Terzaghi, Franca Marino, Cristoforo Comi, Maurizio Versino, Marco Cosentino

{"title":"CD4+ T-cell transcription factors predict phenoconversion in idiopathic rapid eye movement sleep behavior disorder.","authors":"Monica Pinoli, Michele Terzaghi, Franca Marino, Cristoforo Comi, Maurizio Versino, Marco Cosentino","doi":"10.1080/20565623.2024.2418821","DOIUrl":"10.1080/20565623.2024.2418821","url":null,"abstract":"Aim: Early biomarkers of phenoconversion to neurodegeneration are crucial to identify individuals at high risk. In patients with idiopathic REM sleep behavior disorder (iRBD), the strongest risk factor for neurodegeneration, CD4+ T cells exhibit a peculiar transcription factor pattern.Objective: To assess transcription factor mRNA levels in CD4+ T cells as predictive biomarkers of phenoconversion in iRBD patients.Methods: iRBD patients were followed prospectively. ROC curve analysis and Kaplan-Meier curves were used to assess the discrimination between converters and non-converters.Results: CD4+ T cells from converters had higher STAT1, and lower GATA3 and FOXP3 mRNA levels. Hazard ratio was 58.3 (95% CI: 6.2-547.1) for higher STAT1, 101.2 (95% CI: 16.8-609.4) for lower GATA3 and 15.7 (2.7-91.4) for lower FOXP3.Conclusion: STAT1, GATA3 and FOXP3 mRNA levels in CD4+ T cells are promising predictive biomarkers of phenoconversion in iRBD patients.","PeriodicalId":12568,"journal":{"name":"Future Science OA","volume":"10 1","pages":"2418821"},"PeriodicalIF":2.4,"publicationDate":"2024-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11572078/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142618220","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0