Future Science OAPub Date : 2024-05-15eCollection Date: 2024-01-01DOI: 10.2144/fsoa-2023-0248
Sukanya Vijayan, Thirumal Margesan
{"title":"Arthritis alleviation: unveiling the potential in <i>Abrus precatorius</i> macerated oil.","authors":"Sukanya Vijayan, Thirumal Margesan","doi":"10.2144/fsoa-2023-0248","DOIUrl":"10.2144/fsoa-2023-0248","url":null,"abstract":"<p><p><b>Aim:</b> This study endeavors to explore the anti-arthritic effects of macerated oil derived from the plant's aerial parts. <b>Methods:</b> The macerated oil was prepared using maceration in coconut oil, and its phytochemical composition was elucidated using GC-MS. To assess its anti-arthritic activity, <i>in-vitro</i> studies were conducted using various assays. <b>Results & conclusion:</b> The macerated oil showed better antioxidant and anti-arthritic potential by <i>in</i>-<i>vitro</i> investigations. Molecular docking studies elucidated potential binding interactions between specific constituents of the oil and critical molecular targets implicated in the pathogenesis of arthritis, further substantiating its therapeutic potential. The results demonstrated that <i>Abrus precatorius</i> macerated oil could ameliorate arthritis severity in a dose-dependent manner.</p>","PeriodicalId":12568,"journal":{"name":"Future Science OA","volume":null,"pages":null},"PeriodicalIF":2.5,"publicationDate":"2024-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11137774/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141179420","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Future Science OAPub Date : 2024-05-15eCollection Date: 2024-01-01DOI: 10.2144/fsoa-2023-0255
Chintalapati Manogna, Thirumal Margesan
{"title":"<i>In silico</i> and pharmacokinetic studies of glucomoringin from <i>Moringa oleifera</i> root for Alzheimer's disease like pathology.","authors":"Chintalapati Manogna, Thirumal Margesan","doi":"10.2144/fsoa-2023-0255","DOIUrl":"10.2144/fsoa-2023-0255","url":null,"abstract":"<p><p><b>Aim:</b> The aim of this research is to investigate the potential of glucomoringin, derived from <i>Moringa oleifera</i>, as a therapeutic agent for Alzheimer's disease through <i>in silico</i> analysis. <b>Materials & methods:</b> This study employs <i>in silico</i> or computational methodologies, including pkCSM, Swiss ADME, OSIRIS<sup>®</sup> property explorer, PASS online web resource and MOLINSPIRATION<sup>®</sup> software, to predict the pharmacokinetic characteristics and biological activity of glucomoringin. <b>Results & conclusion:</b> Molecular docking indicates strong binding to <i>I-1β</i> and the pharmacokinetic profile shows cytochrome P450 enzyme inhibition, prompting further research for dosing strategies. Toxicological predictions affirm safety, while bioactivity assessments demonstrate versatility in modulating essential pathways. glucomoringin's potential for Alzheimer's treatment, emphasizing the need for additional empirical research.</p>","PeriodicalId":12568,"journal":{"name":"Future Science OA","volume":null,"pages":null},"PeriodicalIF":2.5,"publicationDate":"2024-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11137837/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141179377","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Future Science OAPub Date : 2024-05-15eCollection Date: 2024-01-01DOI: 10.2144/fsoa-2024-0002
Bismark N Mohammed, Emmanuel K Ofori, Christian N Adekena, Seth K Amponsah, Henry Asare-Anane, Seth D Amanquah, Mubarak Abdul-Rahman, Kwesi N Amissah-Arthur
{"title":"Levels of anti-insulin antibodies in diabetic retinopathy patients: an observational cross-sectional study.","authors":"Bismark N Mohammed, Emmanuel K Ofori, Christian N Adekena, Seth K Amponsah, Henry Asare-Anane, Seth D Amanquah, Mubarak Abdul-Rahman, Kwesi N Amissah-Arthur","doi":"10.2144/fsoa-2024-0002","DOIUrl":"10.2144/fsoa-2024-0002","url":null,"abstract":"<p><p><b>Aim:</b> This study evaluated the levels of anti-insulin antibodies (AIAs) and the influence of some antidiabetic medications on AIA in diabetes mellitus (DM) patients with retinopathy. <b>Patient & methods:</b> An observational cross-sectional study. <b>Results:</b> A lower titer of AIA IgG was observed in the diabetic retinopathy (DR) and DM-only study categories compared with the control group [DR = 86 (5-560), DM-only = 50 (5-500), versus control = 200 (7-565); p = 0.017]. Taking nifedipine and metformin were negatively correlated (r = -0.32, p = 0.04) with the levels of AIA IgE in the DR group. <b>Conclusion:</b> A decreased titer of circulating AIAs was observed in the DR study category, suggesting that AIA may not contribute to the pathogenesis of DR.</p>","PeriodicalId":12568,"journal":{"name":"Future Science OA","volume":null,"pages":null},"PeriodicalIF":2.5,"publicationDate":"2024-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11137838/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141179429","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Future Science OAPub Date : 2024-05-15eCollection Date: 2024-01-01DOI: 10.2144/fsoa-2023-0298
Abdikarin Ahmed Mohamed, Yavuz Bastug, Cem Senol, Mohamed Muktar Kassim, Abdisalam Abdullahi Yusuf, Abdikarim Hussein Mohamed
{"title":"Antimicrobial resistance pattern and uropathogens distribution in children visiting a referral hospital in Mogadishu.","authors":"Abdikarin Ahmed Mohamed, Yavuz Bastug, Cem Senol, Mohamed Muktar Kassim, Abdisalam Abdullahi Yusuf, Abdikarim Hussein Mohamed","doi":"10.2144/fsoa-2023-0298","DOIUrl":"10.2144/fsoa-2023-0298","url":null,"abstract":"<p><p><b>Aim:</b> Studies concerning epidemiology and drug susceptibility patterns of pediatric urinary tract infection in developing countries are scarce. This study aimed to evaluate the antimicrobial resistance pattern and uropathogens distribution in children. <b>Method:</b> Four-year retrospective study included 840 participants in all pediatric age groups whose urine had been cultured. <b>Results:</b> The prevalence of culture-proven pediatric UTIs was 17.6% (148/840). <i>Escherichia coli</i> was the most common pathogen isolated from the cultures, accounting for (48%, 71/148), followed by <i>Klebsiella pneumoniae</i> (16.2%, 24/148). About 27% of the pathogens had a multidrug-resistant (MDR) pattern. A resistance rate against nitrofurantoin at 24.6%, fosfomycin at 15.2% and trimethoprim-sulfamethoxazole (SMX-TMP) at 79.7% was noted. <b>Conclusion:</b> <i>E. coli</i> and <i>Klebsiella pneumoniae</i> were the most common pathogens isolated.</p>","PeriodicalId":12568,"journal":{"name":"Future Science OA","volume":null,"pages":null},"PeriodicalIF":2.5,"publicationDate":"2024-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11137854/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141179419","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Future Science OAPub Date : 2024-05-15eCollection Date: 2024-01-01DOI: 10.2144/fsoa-2023-0101
Naser Yamani, Syed Hasham Ali, Mahnoor Sadiq, Afeera B Ahmed, Kapil D Bhojwani, Vivek P Lohana, Saba Fatmah, Shazra Khalid, Hammad R Shamsi, Batool Zehra, Kaneez Fatima, Zulfiqar Q Baloch
{"title":"Trans-femoral versus trans-carotid access for transcatheter aortic valve replacement: an updated systematic review and meta-analysis.","authors":"Naser Yamani, Syed Hasham Ali, Mahnoor Sadiq, Afeera B Ahmed, Kapil D Bhojwani, Vivek P Lohana, Saba Fatmah, Shazra Khalid, Hammad R Shamsi, Batool Zehra, Kaneez Fatima, Zulfiqar Q Baloch","doi":"10.2144/fsoa-2023-0101","DOIUrl":"10.2144/fsoa-2023-0101","url":null,"abstract":"<p><p><b>Aim:</b> This meta-analysis aims to shed light on any primacy the <i>trans</i>-carotid (TC-TAVR) access may have over the <i>trans</i>-femoral access (TF-TAVR) for those undergoing transcatheter aortic valve replacement (TAVR). <b>Methods:</b> PubMed/MEDLINE and Cochrane Library were searched, from inception to March 2023 retrieving seven adjusted studies with a total of 6609 patients, of which 5048 underwent TF-TAVR while 1561 underwent TC-TAVR. <b>Results:</b> No divergence in risk of mortality, major bleeding or stroke/transient ischemic attack in TC-TAVR when compared with TF-TAVR was found. In TC-TAVR, the risk of vascular complications was low (OR: 0.51, 95% CI: 0.32-0.83, p = 0.003) as compared with TF-TAVR. <b>Conclusion:</b> As of this analysis, the viability of TC-TAVR as first alternative to TF-TAVR is plausible.</p>","PeriodicalId":12568,"journal":{"name":"Future Science OA","volume":null,"pages":null},"PeriodicalIF":2.5,"publicationDate":"2024-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11137775/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141181795","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Future Science OAPub Date : 2024-05-15eCollection Date: 2024-01-01DOI: 10.2144/fsoa-2023-0245
Rukaiah Fatma Begum, Sumithra Mohan
{"title":"Systematic exploration of network pharmacology, <i>in silico</i> modeling and pharmacokinetic profiling for vitamin E in polycystic ovarian syndrome.","authors":"Rukaiah Fatma Begum, Sumithra Mohan","doi":"10.2144/fsoa-2023-0245","DOIUrl":"10.2144/fsoa-2023-0245","url":null,"abstract":"<p><p><b>Aim:</b> This study seeks to explore the possibility of using vitamin E to alleviate the symptoms of polycystic ovarian syndrome (PCOS). <b>Methods:</b> Various computational methods were employed, including network pharmacology utilizing a compound-target-pathway approach, Swiss ADME, OSIRIS<sup>®</sup> property explorer, pkCSM, PASS online web resource and MOLINSPIRATION<sup>®</sup> software. In addition, <i>in silico</i> analysis of vitamin E was performed with ten receptors. <b>Results & discussion:</b> Our findings highlight the diverse potential of vitamin E in alleviating PCOS. The observed influence on hormones is in line with existing PCOS theories regarding cyst development, further enhancing the therapeutic promise of vitamin E. <b>Conclusion:</b> In conclusion, our computational analysis indicates that vitamin E shows potential as a therapeutic agent for alleviating PCOS in adolescents.</p>","PeriodicalId":12568,"journal":{"name":"Future Science OA","volume":null,"pages":null},"PeriodicalIF":2.5,"publicationDate":"2024-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11137767/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141179447","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Future Science OAPub Date : 2024-05-15eCollection Date: 2024-01-01DOI: 10.2144/fsoa-2023-0076
Georges Yared, Jihad Al Hasssan, Charlotte Al Hajjar, Kariman Ghazal
{"title":"Post-partum hemorrhage: a multidisciplinary approach to 'the golden hour' quantum leadership and communication.","authors":"Georges Yared, Jihad Al Hasssan, Charlotte Al Hajjar, Kariman Ghazal","doi":"10.2144/fsoa-2023-0076","DOIUrl":"10.2144/fsoa-2023-0076","url":null,"abstract":"<p><p><b>Background:</b> Quantum leadership in postpartum hemorrhage (PPH) simulation training remains underexplored. Quantum leaders excel in PPH's chaotic settings, differing from traditional leaders. <b>Aiming:</b> To assess the impact of simulation training on quantum leadership skills in maternity teams. <b>Research design:</b> A quasi-experimental approach. <b>Sample:</b> 60 maternity professionals from Rafik Hariri University Hospital, Lebanon. <b>Tools:</b> Structured interviews, observational checklists and a leadership skills scale. <b>Results:</b> Most participants had limited PPH simulation experience and showed an initial low proficiency. Significant improvements were evident, post training. <b>Conclusion:</b> Simulation training enhances quantum leadership in PPH management among maternity professionals.</p>","PeriodicalId":12568,"journal":{"name":"Future Science OA","volume":null,"pages":null},"PeriodicalIF":2.5,"publicationDate":"2024-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11140635/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141199589","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}