Future Science OA最新文献_第4页

Harnessing tomato-derived small extracellular vesicles as drug delivery system for cancer therapy. 利用番茄衍生的细胞外小泡作为癌症治疗的药物传递系统。

IF 2.4

Future Science OA Pub Date : 2025-12-01 Epub Date: 2025-02-07 DOI: 10.1080/20565623.2025.2461956

Kartik Kumar Sarwareddy, Anula Divyash Singh, Sreekanth Patnam, Babiola Annes Sesuraj, Spd Ponamgi, Basant Kumar Thakur, Venkata Sasidhar Manda

{"title":"Harnessing tomato-derived small extracellular vesicles as drug delivery system for cancer therapy.","authors":"Kartik Kumar Sarwareddy, Anula Divyash Singh, Sreekanth Patnam, Babiola Annes Sesuraj, Spd Ponamgi, Basant Kumar Thakur, Venkata Sasidhar Manda","doi":"10.1080/20565623.2025.2461956","DOIUrl":"10.1080/20565623.2025.2461956","url":null,"abstract":"Aim: This study aims to explore a sustainable and scalable approach using tomato fruit-derived sEVs (TsEVs) to deliver calcitriol for enhanced anticancer effects, addressing challenges of low yield and high costs associated with mammalian cell-derived sEVs.Methods: TsEVs were isolated by centrifugation and ultrafiltration and characterized using DLS, TEM, and biochemical assays. Calcitriol was loaded into TsEVs via loading methods, with efficiency measured by spectrophotometry and HPLC. HCT116 and HT29 colon cancer cells were treated with TsEV-calcitriol and assessed for viability, colony formation, migration, ROS levels, and apoptosis gene expression.Results: Isolated TsEVs ranged from 30-200 nm with a protein-to-lipid ratio of ∼1. Calcitriol encapsulation efficiencies were 15.4% (passive), 34.8% (freeze-thaw), and 47.3% (sonication). TsEV-calcitriol reduced HCT116 cell viability with IC50 values of 4.05 µg/ml (24 h) and 2.07 µg/ml (48 h). Clonogenic assays showed reduced colony formation and migration. Elevated ROS levels and increased Bax/Bcl-2 ratio were observed in treated HCT116 and HT29 colon cancer cells.Conclusion: These findings highlight TsEVs as a promising alternative drug delivery platform to mammalian cell-derived sEV for enhancing the therapeutic efficiency of calcitriol and other anticancer agents.","PeriodicalId":12568,"journal":{"name":"Future Science OA","volume":"11 1","pages":"2461956"},"PeriodicalIF":2.4,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11812386/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143370686","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Depression among outpatients with diabetic peripheral neuropathy: prevalence and associated factors. 糖尿病周围神经病变门诊患者抑郁：患病率及相关因素

IF 2.4

Future Science OA Pub Date : 2025-12-01 Epub Date: 2025-01-31 DOI: 10.1080/20565623.2025.2458989

Besher Gharaibeh, Aya Baniyones, Sawsan Abuhammad, Amat Al-Khaleq O Mehrass

{"title":"Depression among outpatients with diabetic peripheral neuropathy: prevalence and associated factors.","authors":"Besher Gharaibeh, Aya Baniyones, Sawsan Abuhammad, Amat Al-Khaleq O Mehrass","doi":"10.1080/20565623.2025.2458989","DOIUrl":"10.1080/20565623.2025.2458989","url":null,"abstract":"Aim: This study aims to assess the prevalence of depression among patients with diabetic neuropathy and identify contributing factors.Methods: A cross-sectional descriptive design was used, recruiting 153 patients from outpatient clinics. Participants completed the Beck Depression Inventory II, Michigan Neuropathy Screening Instrument, and Douleur Neuropathique 4 questionnaires, with recent A1C results obtained from medical records.Results: The mean depression score was 16.5, with 98 patients (65%) reporting depression and 20 (13%) indicating moderate to severe depression. Approximately half of the sample experienced neuropathy and neuropathic pain. The mean Michigan Neuropathy Screening Instrument score was 5 (SD = 5), and the Douleur Neuropathique 4 score was 4 (SD = 3.5). Regression analyses showed significant demographic influences on depression. Higher Michigan Neuropathy Screening scores predicted greater depression severity, while DN4 scores did not significantly impact depression levels.Conclusions: Depression in patients with diabetic neuropathy is influenced by the severity of neuropathy. Factors commonly associated with depression in diabetes, such as pain intensity and glycemic control, do not significantly affect depression in the context of neuropathy. These findings highlight the complexity of addressing depression in diabetes care, requiring comprehensive and ongoing approaches.","PeriodicalId":12568,"journal":{"name":"Future Science OA","volume":"11 1","pages":"2458989"},"PeriodicalIF":2.4,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11792793/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143064788","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Validation of salivary proteomic biomarkers for early detection of oral cancer in the Egyptian population. 验证唾液蛋白质组学生物标志物早期检测口腔癌在埃及人口。

IF 2.4

Future Science OA Pub Date : 2025-12-01 Epub Date: 2024-12-06 DOI: 10.1080/20565623.2024.2432222

Dalia Ghalwash, Ahmed Ammar, Asmaa Abou-Bakr, Al-Hassan Diab, Ayman El-Gawish

{"title":"Validation of salivary proteomic biomarkers for early detection of oral cancer in the Egyptian population.","authors":"Dalia Ghalwash, Ahmed Ammar, Asmaa Abou-Bakr, Al-Hassan Diab, Ayman El-Gawish","doi":"10.1080/20565623.2024.2432222","DOIUrl":"10.1080/20565623.2024.2432222","url":null,"abstract":"Purpose: The present study evaluated the sensitivity and specificity of important proteomic salivary biomarkers; IL-6, IL-8, and sCD44 in the early detection of oral cancer, and any possible associations with risk factors of oral cancer in an Egyptian population.Methods: The present investigation was conducted on 100 individuals; 25 healthy controls, 25 patients having oral potentially malignant disorders (OPMDs) with dysplasia; 25 patients having OPMDs without dysplasia, and 25 oral cancer patients. Demographic data modified gingival index, oral hygiene level, and salivary levels of the biomarkers were assessed.Results: Salivary levels of IL-6, IL-8, and sCD44 progressively increased with increased disease severity. Salivary IL-8 and IL-6 levels possess a discriminating potential from normal tissue through different degrees of dysplasia to oral cancer, sCD44 levels had a discriminating power between normal and dysplastic tissues with high sensitivity and specificity. A positive correlation was found between the three biomarkers and the grade of oral squamous cell carcinoma (OSCC) and with different risk factors.Conclusion: This is the first study that evaluated multiple salivary proteomic biomarkers in the Egyptian population, and the results validate the ability of IL-6, IL-8, and sCD44 to be used as sensitive diagnostic and prognostic biomarkers for screening and early detection of oral cancer.","PeriodicalId":12568,"journal":{"name":"Future Science OA","volume":"11 1","pages":"2432222"},"PeriodicalIF":2.4,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11633404/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142784617","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The value of peripheral blood inflammation markers in risk assessment and prediction of lung cancer. 外周血炎症标志物在肺癌风险评估和预测中的价值。

IF 2.4

Future Science OA Pub Date : 2025-12-01 Epub Date: 2025-03-13 DOI: 10.1080/20565623.2025.2476870

Yong Xie, Qi Yu, Yujun Zhu, Wen Wu, Rong Xiao, Naiqun Wang, Liangbo Zhu, Ping Li, Tao Chen

{"title":"The value of peripheral blood inflammation markers in risk assessment and prediction of lung cancer.","authors":"Yong Xie, Qi Yu, Yujun Zhu, Wen Wu, Rong Xiao, Naiqun Wang, Liangbo Zhu, Ping Li, Tao Chen","doi":"10.1080/20565623.2025.2476870","DOIUrl":"10.1080/20565623.2025.2476870","url":null,"abstract":"Background: Lung cancer has high mortality rates globally, with inflammatory processes playing a pivotal role in NSCLC progression. Peripheral blood inflammation markers offer promise for NSCLC risk assessment and prediction.Methods: A retrospective case-control study included 50 NSCLC patients and 50 healthy individuals admitted for routine health examinations as controls. Clinical data were collected, and blood routine tests were conducted on the first day of admission. We compared white blood cells, neutrophils, lymphocytes, monocytes, platelets, NLR (Neutrophil-to-Lymphocyte Ratio), LMR (Lymphocyte-to-Monocyte Ratio), PLR (Platelet-to-Lymphocyte Ratio), dNLR (derived NLR), and SII (Systemic Immune-inflammation Index). Logistic regression and ROC curve analysis were used to evaluate their predictive value.Results: NLR was significantly higher in NSCLC patients than in healthy controls, and elevated NLR was strongly associated with increased odds of having NSCLC. Neutrophil, lymphocyte, and monocyte counts also contributed to the odds of having NSCLC. NLR showed the highest predictive value with an AUC of 0.911, indicating excellent accuracy.increased odds of having NSCLC.Conclusions: Our findings suggest that peripheral blood inflammation markers, particularly the NLR, may have potential utility in risk assessment and prediction for NSCLC. These markers warrant further investigation to explore their potential role in early diagnosis and monitoring of NSCLC.","PeriodicalId":12568,"journal":{"name":"Future Science OA","volume":"11 1","pages":"2476870"},"PeriodicalIF":2.4,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11916372/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143624160","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Oxidative markers and SOD variant: predictors of autism severity and susceptibility. 氧化标记物和SOD变异：自闭症严重程度和易感性的预测因子。

IF 2.4

Future Science OA Pub Date : 2025-12-01 Epub Date: 2025-03-31 DOI: 10.1080/20565623.2025.2483628

Abdullah Abubaker Shareef, Azad Hasan Kheder, Niaz Albarzinji, Karim Jalal Karim, Shukur Wasman Smail, Abuabkr Abdalla Mahmood, Kawa Amin

{"title":"Oxidative markers and SOD variant: predictors of autism severity and susceptibility.","authors":"Abdullah Abubaker Shareef, Azad Hasan Kheder, Niaz Albarzinji, Karim Jalal Karim, Shukur Wasman Smail, Abuabkr Abdalla Mahmood, Kawa Amin","doi":"10.1080/20565623.2025.2483628","DOIUrl":"10.1080/20565623.2025.2483628","url":null,"abstract":"Background: This study examines the relationship between oxidative stress, anti-oxidative markers, and the Ala16Val SOD2 polymorphism in children with autism spectrum disorder (ASD) to better understand ASD severity and susceptibility.Material and methods: The study included 80 children (40 with ASD and 40 controls) from Erbil City, Iraq.Results: Serum antioxidant markers, such as superoxide dismutase (SOD) and glutathione peroxidase (GPX), were significantly lower in ASD patients compared to controls (P = 0.036 and P < 0.001, respectively), while markers of oxidative damage, including malondialdehyde (MDA), nitric oxide (NO), and cytochrome C, were significantly elevated (P < 0.001). Regression analysis revealed reduced SOD and GPX activities were strongly associated with increased autism severity, as measured by the childhood autism rating scale (CARS), while elevated NO and cytochrome C levels also correlated positively with higher CARS scores. Although the Ala16Val SOD polymorphism was not significantly associated with ASD risk, logistic regression showed no connection between SOD genotypes and serum SOD levels.Conclusion: These findings suggest oxidative stress and impaired antioxidant defense play critical roles in ASD severity.","PeriodicalId":12568,"journal":{"name":"Future Science OA","volume":"11 1","pages":"2483628"},"PeriodicalIF":2.4,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11959902/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143752204","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Novel compounds of Taiwanese green propolis induce apoptosis of human glioblastoma cells by daylight photodynamic action. 台湾绿色蜂胶的新化合物通过日光光动力作用诱导人胶质母细胞瘤细胞凋亡。

IF 2.4

Future Science OA Pub Date : 2025-12-01 Epub Date: 2025-02-10 DOI: 10.1080/20565623.2025.2464491

Daniel Tzu-Hsuan Chen, Shin-Yi Huang, Ta-Chun Liu, Yao-Kuan Chen

{"title":"Novel compounds of Taiwanese green propolis induce apoptosis of human glioblastoma cells by daylight photodynamic action.","authors":"Daniel Tzu-Hsuan Chen, Shin-Yi Huang, Ta-Chun Liu, Yao-Kuan Chen","doi":"10.1080/20565623.2025.2464491","DOIUrl":"10.1080/20565623.2025.2464491","url":null,"abstract":"Background: Glioblastoma, an aggressive brain cancer, has limited treatment options and poor prognosis. Taiwanese green propolis, known for its tumor-inhibitory properties, shows promise when combined with photodynamic therapy (PDT), a targeted, low-toxicity treatment. This study investigated a novel Taiwanese green propolis-based compound for inducing apoptosis in glioblastoma cells and its synergistic potential with daylight PDT.Methods: Ethanol extracts of green propolis, wheatgrass, and mulberry leaves were combined and analyzed using High-Performance Liquid Chromatography (HPLC). Apoptosis induction in U87 glioblastoma cells was assessed via the MTT assay following treatment with the compound alone and in combination with daylight PDT at 570 nm.Results: We identified Artepillin C as the main active component in the compound by HPLC, which significantly induced apoptosis in glioblastoma cells. Combined with daylight PDT, it demonstrated enhanced efficacy, with cell viability reduced from 95.2% at 0.25 µL to 11.3% at 8 µL of the compound extract. The EC50 decreased, indicating greater apoptotic activity compared to the extract alone.Conclusion: This study provides the first in vitro evidence of synergistic anti-tumor effects of a Taiwanese green propolis-based compound daylight PDT (GPDT), highlighting a promising novel therapeutic approach that warrants further clinical investigation.","PeriodicalId":12568,"journal":{"name":"Future Science OA","volume":"11 1","pages":"2464491"},"PeriodicalIF":2.4,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11812390/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143382191","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The potential of Abrus precatorius leaves in arthritis alleviation computational approaches through lC-MS analysis. 通过lC-MS分析，Abrus precatorius叶子在关节炎缓解计算方法中的潜力。

IF 2.4

Future Science OA Pub Date : 2025-12-01 Epub Date: 2025-03-25 DOI: 10.1080/20565623.2025.2483131

Sukanya Vijayan, Thirumal Margesan

引用次数: 0

Biodistribution and persistence of human umbilical cord-derived mesenchymal stem cells in NCG mice: a comparative study. 人脐带间充质干细胞在NCG小鼠体内的生物分布和持久性：一项比较研究。

IF 2.4

Future Science OA Pub Date : 2025-12-01 Epub Date: 2025-03-04 DOI: 10.1080/20565623.2025.2471723

Guangyang Liu, Herui Wang, Xin Li, Yi Mi, Chenliang Zhang, Yaoyao Chen, Li Miao, Haomiao Long, Jun He, Qinggang Ge, Yongjun Liu

{"title":"Biodistribution and persistence of human umbilical cord-derived mesenchymal stem cells in NCG mice: a comparative study.","authors":"Guangyang Liu, Herui Wang, Xin Li, Yi Mi, Chenliang Zhang, Yaoyao Chen, Li Miao, Haomiao Long, Jun He, Qinggang Ge, Yongjun Liu","doi":"10.1080/20565623.2025.2471723","DOIUrl":"10.1080/20565623.2025.2471723","url":null,"abstract":"Introduction: This study aims to investigate the biodistribution and persistence of human umbilical cord-derived mesenchymal stem cells (hUC-MSCs) in NCG mice post-intravenous injection, utilizing 89Zr-PET/CT, bioluminescence imaging, multiplex immunohistochemistry (mIHC), and quantitative polymerase chain reaction (qPCR).Methods: hUC-MSCs were labeled with 89Zr-oxine (89Zr-MSCs) or transduced with luciferase gene (Luc-MSCs). Real-time tracking of 89Zr-MSCs lasted for 14-days followed by mIHC staining of hCD73. Real-time tracking of Luc-MSCs lasted for 7-days, followed by mIHC staining of hCD73 and human Alu-based qPCR. All methods adhered to ICH and other regulatory guidelines for development of cell-based drugs.Results: A biodistribution and persistence pattern was observed in the order of lung > liver > kidney > >spleen, although discrepancies were noted for the liver and kidney.Conclusion: Each method exhibited strengths and weaknesses: 89Zr-PET/CT enabled long-term tracking but encountered issues with 89Zr shedding and dead cells; bioluminescence provided specific detection but was hampered by a rapid decline in signal; mIHC identified cells but relied on antigen abundance; qPCR detected minimal cell quantities but was unable to differentiate between live and dead cells. These limitations may obscure the true fate of cells in vivo, highlighting the need for more accurate and reliable assessment techniques.","PeriodicalId":12568,"journal":{"name":"Future Science OA","volume":"11 1","pages":"2471723"},"PeriodicalIF":2.4,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11881841/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143540979","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Primary adenocarcinoma of duodenal bulb mimicking a pancreatic tumor: a case report. 模拟胰腺肿瘤的原发性十二指肠球腺癌1例报告。

IF 2.4

Future Science OA Pub Date : 2025-12-01 Epub Date: 2025-02-04 DOI: 10.1080/20565623.2025.2456651

Eya Slama, S Ben Hamida, S Zaouga, H Elloumi, I Cheikh, A G Dahak, M Missaoui, A Chelibi, I Ganzoui

{"title":"Primary adenocarcinoma of duodenal bulb mimicking a pancreatic tumor: a case report.","authors":"Eya Slama, S Ben Hamida, S Zaouga, H Elloumi, I Cheikh, A G Dahak, M Missaoui, A Chelibi, I Ganzoui","doi":"10.1080/20565623.2025.2456651","DOIUrl":"10.1080/20565623.2025.2456651","url":null,"abstract":"Duodenal bulb adenocarcinoma is a rare malignancy of the gastrointestinal tract. This cancer often presents with an insidious onset, making it challenging to diagnose early. A noteworthy case-study involved a 56 year-old-woman complaining from epigastric transfixing pain, jaundice, and overall health decline. The initial diagnosis suspected was a pancreatic tumor. An abdominal CT scan however showed no abnormality in the pancreas but revealed on the other hand an irregular, non-stenosing, heterogeneous fibrous thickening of the lower aspect of the duodenal bulb. An EGD showed a congested infiltrated area in the post-bulbar region, and Pathological exam confirmed the diagnosis of a primary adenocarcinoma of the duodenal bulb. The purpose of this article is to present the case of a primary adenocarcinoma of duodenal bulb mimicking a pancreatic tumor: a rare presentation of a rare tumor itself and to present points differentiating these two neoplasms. Diagnosis relies on a comprehensive assessment involving clinical, radiological, endoscopic, and histologic features. Integration of advanced imaging modalities, such as CT/MRI, coupled with upper gastrointestinal endoscopy, is crucial for accurate evaluation.","PeriodicalId":12568,"journal":{"name":"Future Science OA","volume":"11 1","pages":"2456651"},"PeriodicalIF":2.4,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11801341/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143188892","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Case report: lichen planus in a patient with ulcerative colitis receiving sulfasalazine: a drug effect or a disease manifestation? 病例报告：溃疡性结肠炎患者接受柳氮磺胺吡啶治疗后出现扁平苔藓：是药物作用还是疾病表现？

IF 2.4

Future Science OA Pub Date : 2025-12-01 Epub Date: 2024-12-05 DOI: 10.1080/20565623.2024.2432240

Ahmed Mohamed Nefzi, Haythem Yacoub, Asmahane Souissi, Hajer Hassine, Dhouha Cherif, Habiba Debbabi, Héla Kchir, Nadia Maamouri

引用次数: 0