Future Science OA最新文献_第4页

Tackling obesity's impact: the need to address metabolic syndrome in osteoarthritis management. 解决肥胖的影响：需要解决骨关节炎管理中的代谢综合征。

IF 2.5

Future Science OA Pub Date : 2026-12-01 Epub Date: 2026-05-25 DOI: 10.1080/20565623.2026.2674951

Samuel Joshua Pragasam Sampath, Vijayalakshmi Venkatesan

引用次数: 0

Mapping ophthalmic research on glycosylation and glycation: a PRISMA-compliant bibliometric and co‑citation analysis. 测绘眼科糖基化和糖基化研究：符合prisma标准的文献计量学和共被引分析。

IF 2.5

Future Science OA Pub Date : 2026-12-01 Epub Date: 2026-04-29 DOI: 10.1080/20565623.2026.2663167

Hongsong Li, Jing Xu, Jiahui Wang, Lina Cheng, Jingjing Fan

{"title":"Mapping ophthalmic research on glycosylation and glycation: a PRISMA-compliant bibliometric and co‑citation analysis.","authors":"Hongsong Li, Jing Xu, Jiahui Wang, Lina Cheng, Jingjing Fan","doi":"10.1080/20565623.2026.2663167","DOIUrl":"10.1080/20565623.2026.2663167","url":null,"abstract":"Background: Enzymatic glycosylation and non-enzymatic glycation contribute significantly to the pathogenesis of major ocular diseases, particularly diabetic retinopathy (DR), age-related macular degeneration (AMD), glaucoma, and cataract. However, the knowledge structure and developmental trajectory of glycosylation-related research in ophthalmology remain unclear.Methods: The literature on the role of enzymatic glycosylation and non-enzymatic glycation modification in ophthalmic diseases from 1997 to 2024 was searched in the core database of Web of Science. Bibliometrics analysis software VOS viewer (version 1.6.20), Citespace (version 6.1.R1), Scimago Graphica (version 6.1.R1), Microsoft Excel 2021.Results: This study analyzed 3,221 publications, all results are available on January 4, 2025. Biochemistry & Molecular Biology was the primary subject area. Research has evolved from early exploration of advanced glycation end products and protein kinase C pathways toward inflammation, biomarker discovery, and risk prediction in specific ocular disorders. Increasing attention has also been directed toward glycosylation-based diagnostic markers and potential therapeutic targets.Conclusion: This bibliometric analysis provides an ophthalmology-centered overview of glycosylation and glycation research, identifying DR as the primary research hub while highlighting emerging translational directions in retinal and other ocular diseases.","PeriodicalId":12568,"journal":{"name":"Future Science OA","volume":"12 1","pages":"2663167"},"PeriodicalIF":2.5,"publicationDate":"2026-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13134405/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147768898","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Comment on "soluble cytokine receptor levels in obstructive sleep apnea patients treated with continuous positive airway pressure therapy". 关于“持续气道正压治疗阻塞性睡眠呼吸暂停患者可溶性细胞因子受体水平”的评论。

IF 2.5

Future Science OA Pub Date : 2026-12-01 Epub Date: 2026-09-12 DOI: 10.1080/20565623.2026.2730025

Duyu Nunya, Kanika Bhatia

引用次数: 0

Parental age, consanguinity, parity, and mode of delivery among children undergoing orchidopexy for cryptorchidism: a retrospective cohort study from Northern Jordan. 来自约旦北部的一项回顾性队列研究：父母年龄、亲缘关系、胎次和分娩方式对隐睾患儿行睾丸切除术的影响。

IF 2.5

Future Science OA Pub Date : 2026-12-01 Epub Date: 2026-09-18 DOI: 10.1080/20565623.2026.2733701

Mohammad Aladaileh, Saleh Abualhaj, Ziydoun Abu-Sanad, Lina Alshadfan, Ayyub Masoud, Zain Aldeen Saleh, Younis Hizzani, Shahed Maaitah, Danya Al Radaideh, Bassem Al Bataineh, Thekra Almgadem, Ethar Rababa, Mahdi Ahmad Alshboul

{"title":"Parental age, consanguinity, parity, and mode of delivery among children undergoing orchidopexy for cryptorchidism: a retrospective cohort study from Northern Jordan.","authors":"Mohammad Aladaileh, Saleh Abualhaj, Ziydoun Abu-Sanad, Lina Alshadfan, Ayyub Masoud, Zain Aldeen Saleh, Younis Hizzani, Shahed Maaitah, Danya Al Radaideh, Bassem Al Bataineh, Thekra Almgadem, Ethar Rababa, Mahdi Ahmad Alshboul","doi":"10.1080/20565623.2026.2733701","DOIUrl":"10.1080/20565623.2026.2733701","url":null,"abstract":"Aims: Cryptorchidism is a common congenital male genitourinary anomaly with multifactorial etiology. Data on parental age, consanguinity, parity, and delivery mode among affected children in Middle Eastern populations remain limited. This study evaluated the distribution of these factors among children undergoing orchidopexy in Northern Jordan.Patients and methods: A retrospective study was conducted at Princess Rahma Teaching Hospital, Northern Jordan, including males aged 1-11 years who underwent orchidopexy for cryptorchidism between January 2016 and July 2024. Data were obtained from medical records and supplemented by structured telephone interviews.Results: The study included 446 patients. Mean paternal and maternal ages were 34.5 ± 7 and 28.5 ± 6.6 years, respectively. Consanguinity was reported in 27.6% of families, 58.3% of births were vaginal deliveries, and 53.6% of families had ≥3 children. Fathers aged ≥40 years accounted for 24% of the cohort, whereas mothers aged ≥35 years represented 18.2%. Consanguineous families had lower paternal age (p = 0.044) and more frequently had parity >5 (11% vs. 3%, p = 0.013).Conclusions: Distinct demographic patterns involving consanguinity, paternal age, and parity were observed among children with cryptorchidism in Northern Jordan, supporting the need for further controlled regional studies.","PeriodicalId":12568,"journal":{"name":"Future Science OA","volume":"12 1","pages":"2733701"},"PeriodicalIF":2.5,"publicationDate":"2026-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13596888/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149001846","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Dapagliflozin for attenuating early anthracycline-associated cardiac changes (DAPA-AIC): a randomized, double-blind, placebo-controlled trial. 达格列净用于减轻早期蒽环类药物相关心脏变化（DAPA-AIC）：一项随机、双盲、安慰剂对照试验

IF 2.5

Future Science OA Pub Date : 2026-12-01 Epub Date: 2026-10-06 DOI: 10.1080/20565623.2026.2741250

Hakar Abdulkareem Saeed, Nidhal Abdulkader Mohammed Ali, Ramadhan Tayeb Othman

{"title":"Dapagliflozin for attenuating early anthracycline-associated cardiac changes (DAPA-AIC): a randomized, double-blind, placebo-controlled trial.","authors":"Hakar Abdulkareem Saeed, Nidhal Abdulkader Mohammed Ali, Ramadhan Tayeb Othman","doi":"10.1080/20565623.2026.2741250","DOIUrl":"10.1080/20565623.2026.2741250","url":null,"abstract":"Aims: To evaluate whether dapagliflozin attenuates early cardiac functional and biomarker changes during anthracycline-based chemotherapy.Materials & methods: In this randomized, double-blind, placebo-controlled phase II trial, 94 adults were assigned 1:1 to dapagliflozin 10 mg once daily or placebo for 4 months; 90 completed follow-up. The primary endpoint was 4-month left ventricular ejection fraction (LVEF), analyzed using analysis of covariance (ANCOVA) adjusted for baseline LVEF. Secondary and exploratory outcomes included cardiac biomarkers and the early-to-late transmitral flow velocity ratio (E/A ratio).Results: Dapagliflozin was associated with higher adjusted 4-month LVEF than placebo (adjusted mean difference, 2.40 percentage points; 95% confidence interval [CI], 1.25-3.54; p < 0.001). Change in LVEF was +0.13 ± 2.28 versus -2.31 ± 3.27 percentage points, respectively. E/A ratio decline was attenuated (p = 0.030). Galectin-3 decreased with dapagliflozin but increased with placebo (p < 0.001), while N-terminal pro-B-type natriuretic peptide (NT-proBNP) increased less (p = 0.004). No major safety signal was observed during the 4-month follow-up.Conclusions: Dapagliflozin was associated with attenuation of early anthracycline-associated cardiac functional and biomarker changes. Larger, longer trials are needed to determine clinical benefit.Clinical trial registration: www.clinicaltrials.gov identifier is NCT06888505. Retrospectively registered.","PeriodicalId":12568,"journal":{"name":"Future Science OA","volume":"12 1","pages":"2741250"},"PeriodicalIF":2.5,"publicationDate":"2026-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13644628/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149107947","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Integrative analysis of adiponectin-related genes reveals immune subtypes and prognostic significance in melanoma. 脂联素相关基因的综合分析揭示了黑色素瘤的免疫亚型和预后意义。

IF 2.5

Future Science OA Pub Date : 2026-12-01 Epub Date: 2026-05-03 DOI: 10.1080/20565623.2026.2664611

Yong Yin, Chun Ren

{"title":"Integrative analysis of adiponectin-related genes reveals immune subtypes and prognostic significance in melanoma.","authors":"Yong Yin, Chun Ren","doi":"10.1080/20565623.2026.2664611","DOIUrl":"10.1080/20565623.2026.2664611","url":null,"abstract":"Aims: This study aimed to explore the prognostic and immune-related associations of adiponectin-related genes in melanoma.Methods: Single nucleotide polymorphism (SNP) and transcriptomic data from the Integrative Epidemiology Unit Open Genome-Wide Association Study database (IEU openGWAS) and The Cancer Genome Atlas Skin Cutaneous Melanoma cohort (TCGA-SKCM) were integrated to identify adiponectin-related genes. Consensus clustering defined molecular subtypes. Differentially expressed genes (DEGs) were analyzed using functional enrichment, protein-protein interaction (PPI), and immune infiltration (CIBERSORT). In vitro assays assessed transcriptional changes following endogenous albumin (ALB) modulation in melanoma cells.Results: Five adiponectin-associated SNPs were linked to melanoma prognosis. Four molecular subtypes with distinct survival outcomes were identified, with ALB-high Cluster 3 showing the poorest prognosis. A total of 702 DEGs were enriched in immune-related pathways, including IL-17 signaling and antigen presentation. ALB was identified as a PPI hub and positively correlated with memory B cells (R = 0.34, P = 0.012). In vitro, ALB overexpression was associated with increased mRNA levels of IL-6, TNF-α, TGF-β, IL-17A, and RORγt.Conclusion: Tumor-associated ALB expression is associated with adverse prognosis and immune-related transcriptional features in melanoma, suggesting its potential as a prognostic biomarker and marker of transcriptomic heterogeneity.","PeriodicalId":12568,"journal":{"name":"Future Science OA","volume":"12 1","pages":"2664611"},"PeriodicalIF":2.5,"publicationDate":"2026-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13138078/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147813717","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The regulatory significance of chondrocyte hypertrophy in maintaining chondrocyte homeostasis, regeneration and repair. 软骨细胞肥大在维持软骨细胞稳态、再生和修复中的调控意义。

IF 2.5

Future Science OA Pub Date : 2026-12-01 Epub Date: 2026-04-20 DOI: 10.1080/20565623.2026.2658207

Jingxin Li, Changliang Ma, Wenting Jiang, Xiaoqiang Chen, Jianquan Liu, Xu Tao, Zhe Zhao, Wencui Li, Zhiqin Deng

{"title":"The regulatory significance of chondrocyte hypertrophy in maintaining chondrocyte homeostasis, regeneration and repair.","authors":"Jingxin Li, Changliang Ma, Wenting Jiang, Xiaoqiang Chen, Jianquan Liu, Xu Tao, Zhe Zhao, Wencui Li, Zhiqin Deng","doi":"10.1080/20565623.2026.2658207","DOIUrl":"10.1080/20565623.2026.2658207","url":null,"abstract":"Chondrocyte hypertrophy is a pivotal biological process in skeletal development and disease progression, with its precise regulation being essential for maintaining cartilage homeostasis and promoting tissue repair. This review systematically summarizes the molecular mechanisms of chondrocyte hypertrophy and its roles in both physiology and pathology, with a focus on its central involvement in osteoarthritis (OA), growth plate dysplasia, and heterotopic ossification. Key signaling pathways, including RUNX2, BMP, Wnt/β-catenin, and PTHrP, orchestrate hypertrophy through intricate crosstalk. Conversely, inhibitory factors such as SOX9, HIFs, and miRNAs preserve chondrocyte phenotype stability. Pathologically, dysregulated hypertrophy drives cartilage matrix degradation, metabolic reprogramming, and pro-inflammatory microenvironments, thereby exacerbating OA progression. Single-cell omics has unveiled cellular heterogeneity in OA cartilage, and innovative biomaterials combined with stem cell therapies offer promising regenerative approaches. However, limitations persist in understanding pathway interactions, replicating in vivo complexity in vitro, and translating findings to clinical applications. Future research should integrate multidisciplinary technologies to develop precise therapeutic strategies, advancing the treatment of cartilage-related disorders. This review is designed as a narrative review, aiming to systematically synthesize the molecular mechanisms, pathophysiological roles, and therapeutic implications of chondrocyte hypertrophy.","PeriodicalId":12568,"journal":{"name":"Future Science OA","volume":"12 1","pages":"2658207"},"PeriodicalIF":2.5,"publicationDate":"2026-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13097783/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147722510","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Comment on: 'Ultrasound-guided injection strategies for lateral epicondylitis-a multicenter randomized comparison of corticosteroid, platelet-rich plasma, and ozone'. 评论：“超声引导下外上髁炎的注射策略——皮质类固醇、富血小板血浆和臭氧的多中心随机比较”。

IF 2.5

Future Science OA Pub Date : 2026-12-01 Epub Date: 2026-08-01 DOI: 10.1080/20565623.2026.2709617

Ritu Raj Singh, Sunita Sharma, Aiyesha Khatun

引用次数: 0

Neurotransmitter receptor-associated gene signature: prognostic and immunosuppressive microenvironment in NSCLC. 神经递质受体相关基因标记：非小细胞肺癌的预后和免疫抑制微环境。

IF 2.1

Future Science OA Pub Date : 2026-12-01 Epub Date: 2026-01-06 DOI: 10.1080/20565623.2025.2610162

Yingyu Yang, Aimin Ge, Yaru Xu, Jianbo Li, Wenwen Shi, Junling Wang, Zhipeng Zhao

{"title":"Neurotransmitter receptor-associated gene signature: prognostic and immunosuppressive microenvironment in NSCLC.","authors":"Yingyu Yang, Aimin Ge, Yaru Xu, Jianbo Li, Wenwen Shi, Junling Wang, Zhipeng Zhao","doi":"10.1080/20565623.2025.2610162","DOIUrl":"10.1080/20565623.2025.2610162","url":null,"abstract":"Objective: This study sought to identify neurotransmitter receptor-related genes (NR-RGs) that are critically involved in non-small cell lung cancer (NSCLC) through bioinformatics approaches.Methods: The TCGA-NSCLC dataset was utilized as the training cohort, while the GSE50081 dataset served as the validation cohort. NR-RGs were curated, and single-sample gene set enrichment analysis (ssGSEA) scores were computed. Subsequently, weighted gene co-expression network analysis (WGCNA) and functional enrichment analyses were conducted. A risk prediction model and a prognostic model were constructed based on identified gene signatures. Finally, a competing endogenous RNA (ceRNA) network was established, and gene expression levels were experimentally validated.Results: 192 differentially expressed genes were identified as candidate NR-RGs. The risk model ultimately highlighted six genes: CPS1, CDH17, NIPAL4, SOX2, CALB2, and KREMEN2 as potential biomarkers. The prognostic model demonstrated robust predictive performance for patient outcomes. Immune infiltration analysis revealed a significant positive correlation between neutrophil abundance and the risk score. Expression analysis indicated that CPS1 and CALB2 were downregulated in NSCLC samples, whereas CDH17, NIPAL4, SOX2, and KREMEN2 were upregulated.Conclusion: The genes CPS1, CDH17, NIPAL4, SOX2, CALB2, and KREMEN2 were identified as prognostic biomarkers in NSCLC, providing insights into their potential roles in disease progression and therapeutic targeting.","PeriodicalId":12568,"journal":{"name":"Future Science OA","volume":"12 1","pages":"2610162"},"PeriodicalIF":2.1,"publicationDate":"2026-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12785200/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145910633","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Assessment of perceived objectivity of clinical evaluation methods in surgical education: an approach using a digital platform. 评估外科教育中临床评估方法的感知客观性：使用数字平台的方法。

IF 2.1

Future Science OA Pub Date : 2026-12-01 Epub Date: 2025-12-15 DOI: 10.1080/20565623.2025.2591440

Dana Amanova, Dmitryi Matyushko, Aiym Bakytzhan, Aiganym Bolatbekova, Yerzhan Sharapatov, Danila Silischev

{"title":"Assessment of perceived objectivity of clinical evaluation methods in surgical education: an approach using a digital platform.","authors":"Dana Amanova, Dmitryi Matyushko, Aiym Bakytzhan, Aiganym Bolatbekova, Yerzhan Sharapatov, Danila Silischev","doi":"10.1080/20565623.2025.2591440","DOIUrl":"10.1080/20565623.2025.2591440","url":null,"abstract":"Aims: This study aimed to examine surgical trainees' perceptions of perceived objectivity across clinical competency assessment methods and to integrate these findings into the design of a digital assessment platform.Methods: A cross-sectional survey was conducted with 154 participants (47 senior medical students, 107 residents in postgraduate years 1-3). A validated questionnaire (Cronbach's alpha = 0.81) assessed perceived objectivity for four formats: multiple-choice testing (MCQ), oral examinations, Mini-Clinical Evaluation Exercise (Mini-CEX), and Objective Structured Clinical Examination (OSCE). Data were analyzed using descriptive statistics, non-parametric criteria, regression models, and thematic review of open responses.Results: Mini-CEX (Median = 1.35, IQR = 1-2) and OSCE (Median = 1.51, IQR = 1-2) were rated most objective, while multiple-choice testing (MCQ) was least (Median = 2, IQR = 2-3). No significant differences were found between 6th- and 7th-year students (p > 0.05). Third-year residents, however, reported lower perceived objectivity for multiple-choice testing (MCQ) (p = 0.001). Regression showed gender predicted perceptions of multiple-choice testing (MCQ) (B = 0.377, p = 0.005), whereas age and training level were not significant.Conclusions: Practice-oriented assessments, particularly OSCE and Mini-CEX, were viewed as most objective. Findings support digital platforms that integrate varied, practice-based formats to ensure equitable and comprehensive evaluation of clinical competence.","PeriodicalId":12568,"journal":{"name":"Future Science OA","volume":"12 1","pages":"2591440"},"PeriodicalIF":2.1,"publicationDate":"2026-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12710900/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145755645","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0