Future Science OA最新文献

{"title":"Pretherapeutic radiological sarcopenia in pancreatic ductal adenocarcinoma: a narrative review.","authors":"Myriam Ayari, Sarah Ben Azouz, Amira Chehaider, Taieb Jomni","doi":"10.1080/20565623.2026.2728654","DOIUrl":"10.1080/20565623.2026.2728654","url":null,"abstract":"<p><p>Pancreatic ductal adenocarcinoma (PDAC) remains one of the deadliest solid malignancies despite advances in surgery, perioperative care, and systemic therapies. Pretherapeutic radiological sarcopenia has emerged as a clinically relevant body-composition phenotype associated with poor outcomes in oncology. This imaging-based concept differs from contemporary geriatric definitions of sarcopenia, which require impaired muscle strength and incorporate low muscle quantity and/or quality. This narrative review critically examines radiological assessment, biological context, prognostic implications, artificial intelligence (AI)-enabled quantification, and interventional evidence in PDAC. A structured narrative search of PubMed/MEDLINE, Embase, and Google Scholar was conducted from database inception through July 31, 2026. Computed tomography (CT)-based skeletal muscle index remains the most widely validated imaging biomarker, although substantial heterogeneity persists in methods and diagnostic thresholds. Low muscle mass is most consistently associated with reduced survival, whereas associations with postoperative morbidity and systemic treatment toxicity are more heterogeneous. Exercise, nutritional, and multimodal cachexia interventions appear feasible and may provide functional or nutritional benefits, but evidence remains insufficient to establish a survival benefit from improving muscle status. AI-based approaches enable scalable body-composition analysis, although external validation, methodological standardization, and prospective clinical integration remain necessary. Overall, radiological sarcopenia is a promising prognostic and potentially actionable phenotype in PDAC.</p>","PeriodicalId":12568,"journal":{"name":"Future Science OA","volume":"12 1","pages":"2728654"},"PeriodicalIF":2.5,"publicationDate":"2026-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13568583/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148919405","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Severe numbness of the mouth and tongue induced by piperacillin/tazobactam: a rare case report.","authors":"Xinqi Huang, Wanlin Liu, Bo Tan, Lichuan Shi, Yongliang Huang, Shuting Wang, Nianqing Yin, Yi Li, Liutao Zheng, Yanli Dai","doi":"10.1080/20565623.2026.2653792","DOIUrl":"10.1080/20565623.2026.2653792","url":null,"abstract":"<p><strong>Background: </strong>Severe oral and tongue numbness induced by piperacillin/tazobactam is extremely rare.</p><p><strong>Results: </strong>A 58-year-old man with bacterial pneumonia developed oral and tongue numbness, dyspnea, and pruritus approximately 4 minutes after intravenous infusion of piperacillin/tazobactam. Based on adverse drug reaction causality assessment, this event was identified as a previously unreported severe adverse drug reaction.</p><p><strong>Discussion: </strong>This case suggests that during clinical use of piperacillin/tazobactam, clinicians should remain vigilant for rare but severe adverse drug reactions even when skin testing is negative, and strengthen medication monitoring to ensure medication safety.</p>","PeriodicalId":12568,"journal":{"name":"Future Science OA","volume":"12 1","pages":"2653792"},"PeriodicalIF":2.5,"publicationDate":"2026-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13102034/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147768866","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diagnostic accuracy of AI-augmented renal ultrasound for degenerative kidney disorders: a systematic review and meta-analysis.","authors":"Mohammadreza Elhaie, Abolfazl Koozari, Amirsaman Soleimani Nasab, Fatemeh Taheri Dehaghi","doi":"10.1080/20565623.2026.2730711","DOIUrl":"10.1080/20565623.2026.2730711","url":null,"abstract":"<p><strong>Introduction: </strong>This systematic review and meta-analysis evaluated artificial intelligence (AI) and radiomics applied to renal ultrasound for the diagnosis, staging, and prognosis of degenerative kidney disorders.</p><p><strong>Methods: </strong>PubMed/MEDLINE, Embase, Scopus, Web of Science, the Cochrane Library, and gray-literature sources were searched without date or language restrictions. Eligible studies applied AI or radiomics to renal ultrasound and reported diagnostic, staging, or prognostic outcomes. Risk of bias and methodological quality were assessed using the Prediction model Risk Of Bias Assessment Tool (PROBAST), Checklist for Artificial Intelligence in Medical Imaging (CLAIM 2024), and Radiomics Quality Score 2.0 (RQS 2.0). Random-effects models were used for diagnostic accuracy synthesis.</p><p><strong>Results: </strong>Thirty-one studies were included. Machine-learning models achieved pooled sensitivity of 0.86 (95% confidence interval 0.82-0.90) and specificity of 0.83 (0.79-0.87); deep-learning models achieved sensitivity of 0.89 (0.84-0.93) and specificity of 0.85 (0.81-0.91). Heterogeneity was substantial and external validation was uncommon.</p><p><strong>Conclusions: </strong>AI-augmented renal ultrasound shows promising diagnostic performance, but heterogeneous populations, limited calibration, and predominantly internal validation constrain clinical generalizability. Prospective multicenter external validation is required.</p>","PeriodicalId":12568,"journal":{"name":"Future Science OA","volume":"12 1","pages":"2730711"},"PeriodicalIF":2.5,"publicationDate":"2026-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13580494/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148929292","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Intraosseous access in neurological emergencies: a critical narrative review and research framework.","authors":"Alzahra'a Al Matairi, Ahmad E Saeed, Bara M Hammadeh, Leen A Alkuttob, Zainab I Bahdar, Bassel Alrabadi, Areen A Melhem, Mohi Alddin Moustafa Mahouk, Tariq D Al-Saadi","doi":"10.1080/20565623.2026.2743713","DOIUrl":"10.1080/20565623.2026.2743713","url":null,"abstract":"<p><p>Timely vascular access is critical in neurological emergencies, where delays in treatment may worsen secondary brain injury and functional outcomes. Intraosseous access offers a rapid alternative when intravenous cannulation is difficult, delayed, or unsuccessful, but its role in neurocritical care remains incompletely defined. PubMed, ScienceDirect, and Scopus were searched from inception through August 2025, with a targeted evidence update through 10 September 2026. This critical narrative review examines the feasibility, pharmacologic considerations, safety, evidence quality, and research gaps surrounding intraosseous access across acute ischemic and hemorrhagic stroke, status epilepticus, traumatic brain injury, neurological infections, metabolic encephalopathy, pediatric neurological emergencies, and cardiac arrest as an indirect neurologic outcome model. Available evidence supports intraosseous access as a technically feasible emergency route in selected scenarios, particularly when vascular access delay may postpone time-sensitive therapy. However, most data are derived from case reports, animal pharmacokinetic studies, heterogeneous emergency cohorts, or extrapolation from resuscitation and trauma literature. Direct evidence demonstrating improved neurologic outcomes remains very limited and varies substantially by condition. Intravenous access should remain preferred when rapidly obtainable, while intraosseous access should be viewed as a temporary rescue bridge rather than a routine early intervention. Prospective condition-specific studies are needed to evaluate drug delivery, timing, insertion site, complications, workflow integration, and meaningful neurologic outcomes before neuro-focused intraosseous protocols can be broadly recommended.</p>","PeriodicalId":12568,"journal":{"name":"Future Science OA","volume":"12 1","pages":"2743713"},"PeriodicalIF":2.5,"publicationDate":"2026-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13644587/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149107919","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Menstrual cycle experiences and Ramadan fasting: a mixed-methods study among Lebanese women.","authors":"Georges Yared, Jihad Al Hassan, Charlotte El Hajjar, Maysaa Traboulsi, Christopher Massaad, Kariman Ghazal","doi":"10.1080/20565623.2026.2644145","DOIUrl":"10.1080/20565623.2026.2644145","url":null,"abstract":"<p><strong>Background: </strong>Ramadan fasting is a central religious practice for Muslims, yet women are exempt during menstruation. Despite this exemption, many still face physical, emotional, and social challenges.</p><p><strong>Objective: </strong>To explore the impact of Ramadan fasting on menstrual cycle patterns, women's perceptions, and coping strategies.</p><p><strong>Methods: </strong>We conducted a mixed-methods study using structured questionnaires that were circulated on social media platforms and in the clinic after Ramadan 2025. Convenience sampling was used as 154 Lebanese women aged 13-45 years took part in the study. Participants with regular cycles were included; those with amenorrhea or menstrual abnormalities were excluded. Both quantitative and qualitative data were analyzed to capture physical, psychological, social, and spiritual dimensions.</p><p><strong>Results: </strong>Over 60% of participants reported fatigue and cramps during menstruation. More than half had cycles lasting 6-7 d, while 28% noticed irregularities during Ramadan. Emotionally, 70% expressed difficulty with not fasting. Social stigma was reported by about one-third, while 55% felt awareness around menstruation in Ramadan was lacking. Of 18% admitted using medication to delay menstruation, and 90% called for health education in religious spaces.</p><p><strong>Conclusions: </strong>Ramadan fasting affects menstrual patterns and psychosocial wellbeing. Community-based awareness and culturally sensitive guidance are essential to support women's health and spirituality.</p>","PeriodicalId":12568,"journal":{"name":"Future Science OA","volume":"12 1","pages":"2644145"},"PeriodicalIF":2.5,"publicationDate":"2026-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13690276/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147485499","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Integrative analysis of adiponectin-related genes reveals immune subtypes and prognostic significance in melanoma.","authors":"Yong Yin, Chun Ren","doi":"10.1080/20565623.2026.2664611","DOIUrl":"10.1080/20565623.2026.2664611","url":null,"abstract":"<p><strong>Aims: </strong>This study aimed to explore the prognostic and immune-related associations of adiponectin-related genes in melanoma.</p><p><strong>Methods: </strong>Single nucleotide polymorphism (SNP) and transcriptomic data from the Integrative Epidemiology Unit Open Genome-Wide Association Study database (IEU openGWAS) and The Cancer Genome Atlas Skin Cutaneous Melanoma cohort (TCGA-SKCM) were integrated to identify adiponectin-related genes. Consensus clustering defined molecular subtypes. Differentially expressed genes (DEGs) were analyzed using functional enrichment, protein-protein interaction (PPI), and immune infiltration (CIBERSORT). In vitro assays assessed transcriptional changes following endogenous albumin (ALB) modulation in melanoma cells.</p><p><strong>Results: </strong>Five adiponectin-associated SNPs were linked to melanoma prognosis. Four molecular subtypes with distinct survival outcomes were identified, with ALB-high Cluster 3 showing the poorest prognosis. A total of 702 DEGs were enriched in immune-related pathways, including IL-17 signaling and antigen presentation. ALB was identified as a PPI hub and positively correlated with memory B cells (<i>R</i> = 0.34, <i>P</i> = 0.012). In vitro, ALB overexpression was associated with increased mRNA levels of <i>IL-6</i>, <i>TNF-α</i>, <i>TGF-β</i>, <i>IL-17A</i>, and <i>RORγt</i>.</p><p><strong>Conclusion: </strong>Tumor-associated ALB expression is associated with adverse prognosis and immune-related transcriptional features in melanoma, suggesting its potential as a prognostic biomarker and marker of transcriptomic heterogeneity.</p>","PeriodicalId":12568,"journal":{"name":"Future Science OA","volume":"12 1","pages":"2664611"},"PeriodicalIF":2.5,"publicationDate":"2026-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13138078/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147813717","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of dental arch measurements between 3D-printed, digital, and stone casts.","authors":"Noor Al Mortadi, Karem H Alzoubi, Mohammad Alzoubi","doi":"10.1080/20565623.2025.2602761","DOIUrl":"10.1080/20565623.2025.2602761","url":null,"abstract":"<p><strong>Background: </strong>The use of computer-aided design and manufacturing technologies in diagnosis, treatment planning, and fabrication of prosthetic restoration is changing how prosthodontic treatment is offered to patients. This study compares the precision of three-dimensional (3D) printed casts produced from optical scanners using the stereolithographic 3D printing technique, their digital replicas, and conventional stone casts.</p><p><strong>Materials and methods: </strong>Impressions were taken from 13 patients. Inter-arch widths (intercanine/premolar/molar) were made for digital and prototyped models and compared with the original stone casts. The measurements on printed and conventional casts were taken using a digital caliper, whereas those on digital casts were measured directly.</p><p><strong>Results: </strong>Digital casts showed significantly higher maxillary and mandibular intercanine width measurements than 3D-printed and Stone (Gypsum) measurements counterparts (p < 0.001). Additionally, digital casts exhibited significantly lower maxillary and mandibular inter-1st molar and inter-2nd molar widths than their 3D printed and gypsum counterparts (p < 0.001). There were no statistically significant differences between measurements obtained with gypsum and 3D-printed casts.</p><p><strong>Conclusion: </strong>The 3D-printed casts may be considered a viable alternative to gypsum casts, offering clinically acceptable precision for diagnosis, treatment planning, and the fabrication of prosthetic restorations. On the other hand, digital cast measurements exhibit significant variations from gypsum and 3D-printed casts.</p>","PeriodicalId":12568,"journal":{"name":"Future Science OA","volume":"12 1","pages":"2602761"},"PeriodicalIF":2.1,"publicationDate":"2026-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12710927/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145755928","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Real-world evidence on off-label underdosing of direct oral anticoagulants in Asian patients with atrial fibrillation: prescribing patterns, determinants, and outcomes.","authors":"Pajaree Mongkhon, Tanaphorn Koonlachad, Purachai Bvornphattanasakul, Sirayut Phatthanasobhon, Supisara Pholprasittito, Supharat Wattanasombat, Natrawee Bureekam","doi":"10.1080/20565623.2026.2708024","DOIUrl":"10.1080/20565623.2026.2708024","url":null,"abstract":"<p><strong>Background: </strong>Off-label underdosing of direct oral anticoagulants (DOACs) is common among Asian patients with atrial fibrillation (AF), partly reflecting concerns about bleeding, yet Southeast Asian data remain limited. This study aimed to characterize DOAC dosing patterns, identify predictors of off-label underdosing, and evaluate associated effectiveness and safety outcomes.</p><p><strong>Methods: </strong>We conducted a retrospective cohort using electronic health records (EHRs) from two tertiary hospitals in Thailand (2015-2023). Incident AF patients initiating dabigatran, rivaroxaban, apixaban, or edoxaban were included. Doses were classified as on-label, underdosed, or overdosed based on guideline criteria. Propensity score-based inverse probability of treatment weighting (PS-IPTW) Cox proportional hazards regression models was used to evaluate ischemic stroke or systemic embolism (ISSE) and bleeding outcomes.</p><p><strong>Results: </strong>Among 553 patients, 20.4% were underdosed, 6.3% overdosed, and 73.2% received on-label dosing. Rivaroxaban was most frequently underdosed. Older age and diabetes mellitus independently predicted underdosing. Compared to on-label dosing, underdosing was not associated with ISSE (adjusted hazard ratio [aHR] 0.48, 95% CI 0.11-2.16; <i>p</i> = 0.336) or bleeding (aHR 1.06, 95% CI 0.30-3.73; <i>p</i> = 0.924).</p><p><strong>Conclusions: </strong>Off-label underdosing occurred in one-fifth of patients but was not associated with significant differences in ISSE or bleeding. Larger, prospective studies in broader Asian and non-Asian populations are warranted.</p>","PeriodicalId":12568,"journal":{"name":"Future Science OA","volume":"12 1","pages":"2708024"},"PeriodicalIF":2.5,"publicationDate":"2026-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13436833/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148663760","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Causal effects of basal metabolic rate and adiposity on obstructive sleep apnea: univariable, multivariable, and bidirectional Mendelian randomization evidence.","authors":"Mengjie Zhang, Chao Li, Xiaoe Wang, Ruirui Liu, Qingge Chen, Chaomin Wu","doi":"10.1080/20565623.2026.2636257","DOIUrl":"10.1080/20565623.2026.2636257","url":null,"abstract":"<p><strong>Background: </strong>Obstructive sleep apnea (OSA) is a common disorder strongly associated with obesity, yet the causal contribution of basal metabolic rate to OSA and the directionality of the OSA-metabolism relationship remain unclear. The objective of this study was to evaluate the independent and potential bidirectional causal relationships between basal metabolic rate and adiposity-related traits with obstructive sleep apnea using Mendelian randomization.</p><p><strong>Methods: </strong>Two-sample Mendelian randomization (MR) was performed using genome-wide association study data from predominantly European populations to evaluate the causal effects of basal metabolic rate, body mass index, and whole-body fat mass on OSA risk and to assess the reverse effects of genetic liability to OSA on basal metabolic rate. Genetic instruments were derived from the UK Biobank genome-wide association study, and the OSA outcome was obtained from a large meta-analysis genome-wide association study. Univariable MR, multivariable MR, reverse MR, and extensive sensitivity analyses (MR-Egger, weighted median, MR-PRESSO, and leave-one-out analyses) were performed.</p><p><strong>Results: </strong>Univariable MR showed that higher genetically predicted basal metabolic rate, body mass index, and whole-body fat mass were each associated with increased OSA risk (IVW odds ratio per SD: basal metabolic rate 1.85, 95% CI 1.62-2.10; body mass index 2.27, 95% CI 2.07-2.49; whole-body fat mass 2.05, 95% CI 1.85-2.28; all <i>p</i> < 0.05). In multivariable MR, the association between basal metabolic rate and OSA was fully attenuated after adjusting for adiposity (p > 0.05), whereas body mass index and whole-body fat mass retained strong independent causal effects (both <i>p</i> < 0.05), indicating that the apparent basal metabolic rate-OSA association is entirely mediated by fat mass. Reverse MR suggested that genetic liability to OSA modestly increases basal metabolic rate (OR = 1.08, 95% CI 1.04-1.12, <i>p</i> < 0.05), although this estimate showed partial sensitivity to pleiotropy.</p><p><strong>Conclusion: </strong>Elevated adiposity is the primary causal driver of OSA. Although basal metabolic rate does not independently influence OSA risk, OSA may increase resting energy expenditure, suggesting a bidirectional relationship. These findings highlight adiposity reduction as a central target for preventing and treating OSA.</p>","PeriodicalId":12568,"journal":{"name":"Future Science OA","volume":"12 1","pages":"2636257"},"PeriodicalIF":2.5,"publicationDate":"2026-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13690284/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147622347","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Soluble cytokine receptor levels in obstructive sleep apnea patients treated with continuous positive airway pressure therapy.","authors":"Sarah Hall Kiriluk, Lisa A Freeburg, Samira Khan, Cameron S McAlpine, Oren Cohen, Vaishnavi Kundel, Mayte Saurez-Farinas, Francis G Spinale, Neomi Shah","doi":"10.1080/20565623.2025.2553471","DOIUrl":"10.1080/20565623.2025.2553471","url":null,"abstract":"<p><strong>Aims: </strong>Continuous positive airway pressure (CPAP) is an established therapy for obstructive sleep apnea (OSA), but how CPAP compliance changes inflammation/cytokine activation remains unclear.</p><p><strong>Materials and methods: </strong>Plasma from patients with OSA (<i>n</i> = 50) and control subjects (<i>n</i> = 6) were subjected to soluble cytokine receptor profiles - an index of cytokine activation.</p><p><strong>Results: </strong>With OSA, plasma levels of sCD30, sEGFR, sIL1RII, and sVEGFR2 increased by over 2-fold (<i>p</i> < 0.05). In CPAP-compliant patients (<i>n</i> = 22), Plasma levels of sCD30, sEGFR, sIL1RI, sIL1RII, sIL2Ra, sVEGFR1, and sVEGFR2 decreased in CPAP compliant patients (<i>n</i> = 22) after 90 d of CPAP, whereas in CPAP non-compliant patients (<i>n</i> = 28), these soluble cytokine profiles remained unchanged.</p><p><strong>Conclusions: </strong>These results identified that a specific set of soluble cytokine receptors, including sCD30, sEGFR, sIL1RII, and sVEGFR2, may serve as indices of cytokine activation in patients with OSA and also identify therapeutic response such as CPAP.</p>","PeriodicalId":12568,"journal":{"name":"Future Science OA","volume":"12 1","pages":"2553471"},"PeriodicalIF":2.5,"publicationDate":"2026-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12915782/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146206633","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}