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Real-world effectiveness of palbociclib in HR+/HER2- metastatic breast cancer: a literature review palbociclib对HR+/HER2-转移性乳腺癌的实际疗效：文献综述
IF 2.5
Future Science OA Pub Date : 2024-01-31 DOI: 10.2144/fsoa-2023-0074
Emilie Adrian Christiansen, I. Kümler
{"title":"Real-world effectiveness of palbociclib in HR+/HER2- metastatic breast cancer: a literature review","authors":"Emilie Adrian Christiansen, I. Kümler","doi":"10.2144/fsoa-2023-0074","DOIUrl":"https://doi.org/10.2144/fsoa-2023-0074","url":null,"abstract":"Approximately 70% of newly diagnosed breast cancers are of the HR+/HER2- subtype. For the treatment of patients with HR+/HER2- metastatic breast cancer, current guidelines recommend the use of a CDK4/6 inhibitor (palbociclib, ribociclib or abemaciclib) in combination with endocrine therapy. In this review we assess existing literature concerning real-world effectiveness of palbociclib. Survival outcomes in terms of progression-free survival and overall survival are discussed and compared among the included real-world studies and in relation to the phase III PALOMA trials.","PeriodicalId":12568,"journal":{"name":"Future Science OA","volume":null,"pages":null},"PeriodicalIF":2.5,"publicationDate":"2024-01-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140475111","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Clinical approach and utilizing liquid biopsies to interrogate suspected acquired resistance to PD-1 blockade 临床方法和利用液体活检检测 PD-1 阻断剂的疑似获得性抗药性
IF 2.5
Future Science OA Pub Date : 2024-01-31 DOI: 10.2144/fsoa-2023-0010
D. D. De Silva, Jia Luo
{"title":"Clinical approach and utilizing liquid biopsies to interrogate suspected acquired resistance to PD-1 blockade","authors":"D. D. De Silva, Jia Luo","doi":"10.2144/fsoa-2023-0010","DOIUrl":"https://doi.org/10.2144/fsoa-2023-0010","url":null,"abstract":"PD-1 blockade is now routine for nearly all patients with non-small lung cancer. Acquired resistance to PD-1 blockade – defined generally as an initial response followed later by progression [ 1–3 ] is a common yet poorly understood concept. A key clinical challenge to insight has been a lack of standard guidance for clinical management of a case of suspected acquired resistance. The infrequency of performing tumor biopsies and the uncertainty of actionability from tissue sampling likely also contribute to limited insight into the biology of acquired resistance [ 4 ]. To address this knowledge gap and to highlight the value of tumor and liquid biopsy, we present a representative case of suspected acquired resistance to PD-1 blockade and propose a multi-modal guide for approaching this clinical scenario.","PeriodicalId":12568,"journal":{"name":"Future Science OA","volume":null,"pages":null},"PeriodicalIF":2.5,"publicationDate":"2024-01-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140471533","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Attitude towards seeking professional help for mental health among medical students In Karachi, Pakistan 巴基斯坦卡拉奇医学生对寻求心理健康专业帮助的态度
IF 2.5
Future Science OA Pub Date : 2024-01-17 DOI: 10.2144/fsoa-2023-0114
Mubashir Zafar, Tafazzul H Zaidi, Nadira H Zaidi, Muhammad WN Ahmed, Sobia Memon, Faheem Ahmed, Amal Siddiqui, Abeen Fatima, A. Shahid, Balaj Hussain, Anosha Salam
{"title":"Attitude towards seeking professional help for mental health among medical students In Karachi, Pakistan","authors":"Mubashir Zafar, Tafazzul H Zaidi, Nadira H Zaidi, Muhammad WN Ahmed, Sobia Memon, Faheem Ahmed, Amal Siddiqui, Abeen Fatima, A. Shahid, Balaj Hussain, Anosha Salam","doi":"10.2144/fsoa-2023-0114","DOIUrl":"https://doi.org/10.2144/fsoa-2023-0114","url":null,"abstract":"Aim: In Pakistan, seeking help for mental health is considered a social stigma and a large number of medical students are suffering from mental health. This study aimed to investigate the attitude toward seeking professional care for mental health issues among medical students. Methodology: A cross-sectional study was conducted with a total of 316 students selected through multistage stratified cluster sampling. With each academic year 500 students were enrolled. Linear regression analysis was used to find the association of outcome and independent variables. Results: Around 56% of students had a negative attitude toward seeking professional help. Common predictors associated with a negative attitude were age (p < 0.001), academic year (p < 0.001) and with self-harm behavior (p < 0.001). Conclusion: University students generally had moderate intentions to seek counseling regarding mental health.","PeriodicalId":12568,"journal":{"name":"Future Science OA","volume":null,"pages":null},"PeriodicalIF":2.5,"publicationDate":"2024-01-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139617330","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Nanofabrication of chitosan-based dressing to treat the infected wounds: in vitro and in vivo evaluations 治疗感染伤口的壳聚糖基纳米敷料：体外和体内评估
IF 2.5
Future Science OA Pub Date : 2024-01-17 DOI: 10.2144/fsoa-2023-0077
Maryam Yousefi, R. Ghahremanzadeh, Mohammad-Reza Nejadmoghaddam, Fatemeh Yazdi Samadi, Somayeh Najafzadeh, Fereshteh Mohammadi Fatideh, Zohreh Mohammadi, Arash Minai-Tehrani
{"title":"Nanofabrication of chitosan-based dressing to treat the infected wounds: in vitro and in vivo evaluations","authors":"Maryam Yousefi, R. Ghahremanzadeh, Mohammad-Reza Nejadmoghaddam, Fatemeh Yazdi Samadi, Somayeh Najafzadeh, Fereshteh Mohammadi Fatideh, Zohreh Mohammadi, Arash Minai-Tehrani","doi":"10.2144/fsoa-2023-0077","DOIUrl":"https://doi.org/10.2144/fsoa-2023-0077","url":null,"abstract":"Aim: Here, an innovative kind of antibacterial nanocomposite film is developed by incorporating graphene oxide and zinc oxide into chitosan matrix. Materials & methods: Our dressing was fabricated using the solution casting method. Fourier transform infrared spectra and TGA-DTG clearly confirmed the structure of film dressing. Results & conclusion: Our results showed the tensile strength and elongation at the break of the films were 20.1 ± 0.7 MPa and 36 ± 10%, respectively. Our fabricated film could absorb at least three-times the fluid of its dry weight while being biocompatible, antibacterial, non-irritant and non-allergic. In addition, it accelerated the healing process of infected wounds by regulating epithelium thickness and the number of inflammatory cells, thus it may be useful for direct application to damaged infected wounds.","PeriodicalId":12568,"journal":{"name":"Future Science OA","volume":null,"pages":null},"PeriodicalIF":2.5,"publicationDate":"2024-01-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139617935","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Fischer's oligopeptide ratio in ischemic hypoxia: prophylactic amendment of sophoretin and melatonin supplementation 缺血缺氧时的费舍尔低聚肽比值：补充苏醒素和褪黑素的预防性修正作用
IF 2.5
Future Science OA Pub Date : 2024-01-17 DOI: 10.2144/fsoa-2023-0117
Mai O Kadry, H. Ali
{"title":"Fischer's oligopeptide ratio in ischemic hypoxia: prophylactic amendment of sophoretin and melatonin supplementation","authors":"Mai O Kadry, H. Ali","doi":"10.2144/fsoa-2023-0117","DOIUrl":"https://doi.org/10.2144/fsoa-2023-0117","url":null,"abstract":"Aim: The fundamental pathophysiology of ischemic-hypoxia is oxygen depletion. Fischer's ratio is essential for monitoring hypoxia intensity. Methods: the current study highlighted the prophylactic role of sophoretin (QRC) and/or melatonin (MLN) versus sodium nitrite (SN) brain hypoxia. Results: Prophylactic treatment with sophoretin and MLN, was preceded with hypoxia-induction via sodium nitrite (60 mg/kg, S.C.). SN decreased hemoglobin (Hb), elevated  HIF-α, HSP-70, IL-6 and TNF-α. Sophoretin and/or MLN restored the ameliorated inflammatory biomarkers, modulated norepinephrine, dopamine, serotonin and gamma-aminobutyric acid (GABA). Similarly, single-cell gel electrophoresis (SCGE or COMET) DNA-damage assay confirmed this finding. Conclusion: Treatment via sophoretin and MLN was the most effective therapy for improving sodium nitrite induced brain injury.","PeriodicalId":12568,"journal":{"name":"Future Science OA","volume":null,"pages":null},"PeriodicalIF":2.5,"publicationDate":"2024-01-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139616898","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Guillain-Barré syndrome in ulcerative colitis and SARS-CoV-2 infection: a case report and literature review 溃疡性结肠炎和 SARS-CoV-2 感染引发的格林-巴利综合征：病例报告和文献综述
IF 2.5
Future Science OA Pub Date : 2024-01-15 DOI: 10.2144/fsoa-2023-0125
S. Ayadi, Rabeb Hammouga, Slym Majoul, H. Jamoussi, Y. Zaimi, A. Mensi, Mohamed Fredj, Leila Mouelhi
{"title":"Guillain-Barré syndrome in ulcerative colitis and SARS-CoV-2 infection: a case report and literature review","authors":"S. Ayadi, Rabeb Hammouga, Slym Majoul, H. Jamoussi, Y. Zaimi, A. Mensi, Mohamed Fredj, Leila Mouelhi","doi":"10.2144/fsoa-2023-0125","DOIUrl":"https://doi.org/10.2144/fsoa-2023-0125","url":null,"abstract":"Aim: Guillain-Barré syndrome (GBS) occurrence is rare during inflammatory bowel disease (IBD) and SARS-CoV-2 infection. Its association with thrombotic vascular events, which are common during these two entities, is extremely rare. Case report: We report an exceptional association of GBS and cerebral venous thrombosis in a 28-year-old woman with active ulcerative colitis and no previous history of SARS-CoV-2 vaccination. Mildly symptomatic SARS-CoV-2 infection was diagnosed during etiological investigations of cerebral venous thrombosis. GBS symptoms began 10 days later with clinical and electrical abnormalities consistent with axonal GBS. Other GBS causes were excluded. Favorable outcomes were noted after intravenous immunoglobulin perfusion with full recovery 12 months later. Conclusion: Greater attention should be focused on IBD patients with SARS-CoV-2 infection regardless of its severity.","PeriodicalId":12568,"journal":{"name":"Future Science OA","volume":null,"pages":null},"PeriodicalIF":2.5,"publicationDate":"2024-01-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139529137","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Unleashing light's healing power: an overview of photobiomodulation for Alzheimer's treatment 释放光的治疗力量：光生物调制治疗老年痴呆症概述
IF 2.5
Future Science OA Pub Date : 2024-01-11 DOI: 10.2144/fsoa-2023-0155
Aakash Ramanishankar, Ankul Singh S, Rukaiah F Begum, Narayanan Jayasankar, Afreen Nayeem, B. Prajapati, Shanmugasundaram Nirenjen
{"title":"Unleashing light's healing power: an overview of photobiomodulation for Alzheimer's treatment","authors":"Aakash Ramanishankar, Ankul Singh S, Rukaiah F Begum, Narayanan Jayasankar, Afreen Nayeem, B. Prajapati, Shanmugasundaram Nirenjen","doi":"10.2144/fsoa-2023-0155","DOIUrl":"https://doi.org/10.2144/fsoa-2023-0155","url":null,"abstract":"Aim: Photobiomodulation involves the use of low-level light therapy or near-infrared light therapy found to be useful in the treatment of a wide range of neurological diseases. Objective: The aim is to review the mechanism and clinical applications of photobiomodulation therapy (PBMT) in managing Alzheimer's disease. Methods: To ensure that the consensus statement accurately reflects both the experts' viewpoint and the most recent developments in the field, the expert opinions were recorded and thoroughly reviewed. Results: PBMT elicits reduction of beta-amyloid plaque, restoration of mitochondrial function, anti-inflammatory and antioxidant properties with a stimulation in ATP synthesis. Conclusion: The PBMT could be helpful in patients non-responsive to traditional pharmacological therapy providing significant aid in the management of Alzheimer's disease when introduced into the medical field.","PeriodicalId":12568,"journal":{"name":"Future Science OA","volume":null,"pages":null},"PeriodicalIF":2.5,"publicationDate":"2024-01-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139438625","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Statin use is not associated with inflammation among Chilean women of Mapuche and non-Mapuche ancestry with gallstones 使用他汀类药物与患有胆结石的智利马普切和非马普切血统妇女的炎症无关
IF 2.5
Future Science OA Pub Date : 2024-01-11 DOI: 10.2144/fsoa-2023-0032
Sarah S. Jackson, Marina Lex, Vanessa Van De Wyngard, Paz Cook, Allan Hildesheim, Ligia A Pinto, Sharon H Jackson, Kelvin Choi, T. Minas, Héctor Fabio Losada Morales, Juan Carlos Araya, C. Ferreccio, J. Koshiol, Ruth Pfeiffer
{"title":"Statin use is not associated with inflammation among Chilean women of Mapuche and non-Mapuche ancestry with gallstones","authors":"Sarah S. Jackson, Marina Lex, Vanessa Van De Wyngard, Paz Cook, Allan Hildesheim, Ligia A Pinto, Sharon H Jackson, Kelvin Choi, T. Minas, Héctor Fabio Losada Morales, Juan Carlos Araya, C. Ferreccio, J. Koshiol, Ruth Pfeiffer","doi":"10.2144/fsoa-2023-0032","DOIUrl":"https://doi.org/10.2144/fsoa-2023-0032","url":null,"abstract":"Aim: Statins are associated with lower risk of gallstones due to anti-inflammatory effects. We assessed whether statins impact circulating inflammation among Chilean women with gallstones. Materials & methods: 200 Mapuche women were matched on statin use and age to 200 non-Mapuche women in the Chile Biliary Longitudinal Study. We analyzed 92 inflammatory biomarkers using multivariable-adjusted regression models, random forests and pathway analyses. Results: Statins were not significantly associated with any inflammation marker when women were analyzed jointly or stratified by ancestry. No significant associations were found through random forest methods and pathway analyses. Discussion: We did not find significant associations between statin use and inflammation markers in women with gallstones, suggesting that statins do not reduce inflammation once gallstones have formed.","PeriodicalId":12568,"journal":{"name":"Future Science OA","volume":null,"pages":null},"PeriodicalIF":2.5,"publicationDate":"2024-01-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139625309","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
SARS-CoV-2-induced phosphorylation and its pharmacotherapy backed by artificial intelligence and machine learning 由人工智能和机器学习支持的 SARS-CoV-2 诱导的磷酸化及其药物疗法
IF 2.5
Future Science OA Pub Date : 2024-01-10 DOI: 10.2144/fsoa-2023-0112
Fouzia Qamar, Zubair Sharif, J. Idrees, Asif Wasim, Sana Haider, Saad Salman
{"title":"SARS-CoV-2-induced phosphorylation and its pharmacotherapy backed by artificial intelligence and machine learning","authors":"Fouzia Qamar, Zubair Sharif, J. Idrees, Asif Wasim, Sana Haider, Saad Salman","doi":"10.2144/fsoa-2023-0112","DOIUrl":"https://doi.org/10.2144/fsoa-2023-0112","url":null,"abstract":"Aims: To investigate the role of phosphorylation in SARS-CoV-2 infection, potential therapeutic targets and its harmful genetic sequences. Materials & Methods: Data mining techniques were employed to identify upregulated kinases responsible for proteomic changes induced by SARS-CoV-2. Spike and nucleocapsid proteins' sequences were analyzed using predictive tools, including SNAP2, MutPred2, PhD-SNP, SNPs&Go, MetaSNP, Predict-SNP and PolyPhen-2. Missense variants were identified using ensemble-based algorithms and homology/structure-based models like SIFT, PROVEAN, Predict-SNP and MutPred-2. Results: Eight missense variants were identified in viral sequences. Four damaging variants were found, with SNPs&Go and PolyPhen-2. Promising therapeutic candidates, including gilteritinib, pictilisib, sorafenib, RO5126766 and omipalisib, were identified. Conclusion: This research offers insights into SARS-CoV-2 pathogenicity, highlighting potential treatments and harmful variants in viral proteins.","PeriodicalId":12568,"journal":{"name":"Future Science OA","volume":null,"pages":null},"PeriodicalIF":2.5,"publicationDate":"2024-01-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139439835","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
GC-MS analysis of an ethanolic extract of Ocimum species: a network pharmacology analysis insight towards obesity 欧加木乙醇提取物的气相色谱-质谱分析：网络药理学分析对肥胖症的启示
IF 2.5
Future Science OA Pub Date : 2024-01-10 DOI: 10.2144/fsoa-2023-0202
Priyadharshini Gnanamurthy, Manoj K Narasimhan, Sarvesh Sabarathinam
{"title":"GC-MS analysis of an ethanolic extract of Ocimum species: a network pharmacology analysis insight towards obesity","authors":"Priyadharshini Gnanamurthy, Manoj K Narasimhan, Sarvesh Sabarathinam","doi":"10.2144/fsoa-2023-0202","DOIUrl":"https://doi.org/10.2144/fsoa-2023-0202","url":null,"abstract":"Aim: In this study, we have selected two different Ocimum tenuiflorum plants, Ocimum tenuiflorum (Rama tulsi) (OTRT) and Ocimum tenuiflorum (Krishna tulsi) (OTKT). Materials & methods: In the present investigation, ethanol was used as a solvent to estimate the bioactive compounds present in it through gas chromatography-mass spectrometry (GC–MS). Results: Based on the GC-MS data benzenepropanoic acid, 3-methoxy-alpha,4-bis[(trimethylsilyl)oxy was found to be the potent compound in OTRT (MW:428.74 g/mol) and methyl 3-(4-benzyloxy-3,5-dimethoxyphenyl)-2-methylpropanoate in OTKT (MW:342.39 g/mol). To estimate its pharmacological application, an integrated Network Pharmacology approach is performed toward the disease target obesity. Conclusion: From the Protein–Protein interaction from the string database, SRC, BCL2, EGFR, MTOR, CDK1, ERBB2, MAPK1, FYN, AR and MAPK14 are the top-ranked targets.","PeriodicalId":12568,"journal":{"name":"Future Science OA","volume":null,"pages":null},"PeriodicalIF":2.5,"publicationDate":"2024-01-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139439094","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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