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Recurrent primary hepatic VIPoma treated with a combination of surgical resection and loco-regional therapy. 复发性原发性肝脂肪瘤手术切除加局部局部治疗。
IF 2.5
Future Science OA Pub Date : 2023-01-01 DOI: 10.2144/fsoa-2022-0046
Wafa Dahmani, Sahar Nasr, Kais Maalel, Yasser Becheikh, Ahmed Tibaoui, Zainab Lajmi, Sihem Hmissa, Hanene Jaziri, Nour Elleuch, Aida Ben Slama, Wafa Ben Ameur, Mahdi Ksiaa, Ali Jmaa
{"title":"Recurrent primary hepatic VIPoma treated with a combination of surgical resection and loco-regional therapy.","authors":"Wafa Dahmani,&nbsp;Sahar Nasr,&nbsp;Kais Maalel,&nbsp;Yasser Becheikh,&nbsp;Ahmed Tibaoui,&nbsp;Zainab Lajmi,&nbsp;Sihem Hmissa,&nbsp;Hanene Jaziri,&nbsp;Nour Elleuch,&nbsp;Aida Ben Slama,&nbsp;Wafa Ben Ameur,&nbsp;Mahdi Ksiaa,&nbsp;Ali Jmaa","doi":"10.2144/fsoa-2022-0046","DOIUrl":"https://doi.org/10.2144/fsoa-2022-0046","url":null,"abstract":"<p><p>Vasoactive intestinal peptide (VIP) secreting tumors (VIPomas) are insidious functional neuroendocrine tumors originating mainly from pancreatic islet cells. Hepatic localization is considered exceedingly rare as only few cases have been reported in the literature. Diagnostic and therapeutic management of this tumor is still not clearly codified and therefore represents a real challenge for clinicians. Herein we report a unique case of a primary hepatic VIPoma recurrence in a female patient 22 years after curative resection. The patient had two sessions of transarterial chemoembolization. Complete symptomatic improvement was achieved since the first day after the first session. This case highlights that long-term follow-up for patients with hepatic VIPoma is mandatory as recurrence could occur several years after curative surgical treatment.</p>","PeriodicalId":12568,"journal":{"name":"Future Science OA","volume":"9 1","pages":"FSO836"},"PeriodicalIF":2.5,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10051143/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9241056","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Comparison of four DNA extraction kits efficiency for 16SrDNA microbiota profiling of diverse human samples. 四种DNA提取试剂盒对不同人类样本16SrDNA微生物群分析效率的比较。
IF 2.5
Future Science OA Pub Date : 2023-01-01 DOI: 10.2144/fsoa-2022-0072
Sandrine Le Gall-David, Gaëlle Boudry, Sylvie Buffet-Bataillon
{"title":"Comparison of four DNA extraction kits efficiency for 16SrDNA microbiota profiling of diverse human samples.","authors":"Sandrine Le Gall-David,&nbsp;Gaëlle Boudry,&nbsp;Sylvie Buffet-Bataillon","doi":"10.2144/fsoa-2022-0072","DOIUrl":"https://doi.org/10.2144/fsoa-2022-0072","url":null,"abstract":"<p><strong>Aim: </strong>The current study investigated the performance of 4 widely used DNA extraction kits using different types of high (stool) and low biomass samples (chyme, broncho alveolar lavage and sputum).</p><p><strong>Methods: </strong>Qiagen Powerfecal Pro DNA kit, Macherey Nucleospin Soil kit, Macherey Nucleospin Tissue Kit and MagnaPure LC DNA isolation kit III were evaluated in terms of DNA quantity, quality, diversity and composition profiles.</p><p><strong>Results: </strong>The quantity and quality of DNA varied among the four kits. The microbiota of the stool samples showed similar diversity and compositional profiles for the 4 kits.</p><p><strong>Conclusion: </strong>Despite differences in DNA quality and quantity, the 4 kits yielded similar results for stool samples, while all kits were not sensitive enough for low biomass samples.</p>","PeriodicalId":12568,"journal":{"name":"Future Science OA","volume":"9 1","pages":"FSO837"},"PeriodicalIF":2.5,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10051199/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9241059","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The soluble suppression of tumorigenicity 2 as a biomarker of early cardiac remodeling in bradycardia patients receiving permanent pacemaker therapy. 可溶性抑制致瘤性2作为接受永久性起搏器治疗的心动过缓患者早期心脏重构的生物标志物。
IF 2.5
Future Science OA Pub Date : 2023-01-01 DOI: 10.2144/fsoa-2023-0001
Mohammad Iqbal, Iwan Cahyo Santosa Putra, Rizki Bunawan, Hanna Goenawan, Mohammad Rizki Akbar, Arief Sjamsulaksan Kartasasmita, Young Hoon Kim
{"title":"The soluble suppression of tumorigenicity 2 as a biomarker of early cardiac remodeling in bradycardia patients receiving permanent pacemaker therapy.","authors":"Mohammad Iqbal,&nbsp;Iwan Cahyo Santosa Putra,&nbsp;Rizki Bunawan,&nbsp;Hanna Goenawan,&nbsp;Mohammad Rizki Akbar,&nbsp;Arief Sjamsulaksan Kartasasmita,&nbsp;Young Hoon Kim","doi":"10.2144/fsoa-2023-0001","DOIUrl":"https://doi.org/10.2144/fsoa-2023-0001","url":null,"abstract":"<p><strong>Aim: </strong>This study aims to evaluate: the difference of soluble suppression of tumorigenicity 2 (sST2) level, a biomarker for cardiac remodeling and echocardiography parameters value prior to and 1 month after implantation; and the association between pacemaker parameters and pacemaker mode along with delta sST2 levels.</p><p><strong>Materials & methods: </strong>This prospective cohort study enrolled all symptomatic bradycardia patients aged >18 years with preserved ejection fraction who underwent permanent pacemaker (PPM) implantation.</p><p><strong>Results: </strong>A total of 49 patients were included in this study. The sST2 level (ng/ml) were significantly different between prior and 1 month following PPM implantation (23.4 ± 28.4 vs 39.9 ± 63.7; p = 0.001).</p><p><strong>Conclusion: </strong>The early cardiac remodeling has occurred within 1 month after PPM implantation as indicated by increasing delta sST2 level.</p>","PeriodicalId":12568,"journal":{"name":"Future Science OA","volume":"9 1","pages":"FSO831"},"PeriodicalIF":2.5,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10051037/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9241058","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Exosomes as crucial emerging tools for intercellular communication with therapeutic potential in ovarian cancer. 外泌体作为卵巢癌细胞间通讯的重要新兴工具，具有治疗潜力。
IF 2.5
Future Science OA Pub Date : 2023-01-01 DOI: 10.2144/fsoa-2022-0032
Shika Hanif Malgundkar, Yahya Tamimi
{"title":"Exosomes as crucial emerging tools for intercellular communication with therapeutic potential in ovarian cancer.","authors":"Shika Hanif Malgundkar,&nbsp;Yahya Tamimi","doi":"10.2144/fsoa-2022-0032","DOIUrl":"https://doi.org/10.2144/fsoa-2022-0032","url":null,"abstract":"<p><p>More than two-thirds of epithelial ovarian cancer (EOC) patients are diagnosed at advanced stages due to the lack of sensitive biomarkers. Currently, exosomes are intensively investigated as non-invasive cancer diagnostic markers. Exosomes are nanovesicles released in the extracellular milieu with the potential to modulate recipient cells' behavior. EOC cells release many altered exosomal cargoes that exhibit clinical relevance to tumor progression. Exosomes represent powerful therapeutic tools (drug carriers or vaccines), posing a promising option in clinical practice for curing EOC in the near future. In this review, we highlight the importance of exosomes in cell-cell communication, epithelial-mesenchymal transition (EMT), and their potential to serve as diagnostic and prognostic factors, particularly in EOC.</p>","PeriodicalId":12568,"journal":{"name":"Future Science OA","volume":"9 1","pages":"FSO833"},"PeriodicalIF":2.5,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10051132/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9241057","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
The expression profiling of serum miR-92a, miR-134 and miR-375 in acute ischemic stroke. 急性缺血性脑卒中患者血清miR-92a、miR-134和miR-375的表达谱
IF 2.5
Future Science OA Pub Date : 2022-12-01 DOI: 10.2144/fsoa-2022-0074
Aya Tarek Salman, Olfat Shaker, Shereen Saeid Elshaer, Ahmed Elshafei
{"title":"The expression profiling of serum miR-92a, miR-134 and miR-375 in acute ischemic stroke.","authors":"Aya Tarek Salman,&nbsp;Olfat Shaker,&nbsp;Shereen Saeid Elshaer,&nbsp;Ahmed Elshafei","doi":"10.2144/fsoa-2022-0074","DOIUrl":"https://doi.org/10.2144/fsoa-2022-0074","url":null,"abstract":"<p><strong>Aim: </strong>To investigate the expression profile and diagnostic potentials of serum miR-92a, 134, and 375 in acute ischemic stroke (AIS) patients.</p><p><strong>Materials & methods: </strong>Serum miRs-92a, 134, and 375 expression profiles were estimated by qRT-PCR for 70 AIS patients, age-matched with 25 control subjects. Their diagnostic potential was estimated by ROC analysis.</p><p><strong>Results: </strong>Down-expression of miR-92a and miR-375 was found (56; 96.5%; -1.86 ± 1.36; and 53; 91.4%; -1.63 ± 1.38, respectively), while miR-134 showed a predominant upregulation (46; 79.3%; 0.853 ± 1.34). The diagnostic accuracy was the highest for miR-92a and miR-375 (area under the curve = 0.9183 and 0.898, respectively), with greater specificity for miR-375 (Sp = 96%).</p><p><strong>Conclusion: </strong>Serum miR-92a and miR-375 could be promising early detective biomarkers of AIS.</p>","PeriodicalId":12568,"journal":{"name":"Future Science OA","volume":"8 10","pages":"FSO829"},"PeriodicalIF":2.5,"publicationDate":"2022-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9979103/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9100207","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 9
Assessing the knowledge, attitudes and barriers regarding health promotion of breast cancer among community pharmacists. 评估社区药师在促进乳腺癌健康方面的知识、态度和障碍。
IF 2.5
Future Science OA Pub Date : 2022-12-01 DOI: 10.2144/fsoa-2022-0051
Muna Oqal, Mohanad Odeh, Rawan Abudalu, Abdelrahim Alqudah, Roaa Alnajjar, Yazeed Bani Younes, Maram Al-Shawabkeh, Luma Taha
{"title":"Assessing the knowledge, attitudes and barriers regarding health promotion of breast cancer among community pharmacists.","authors":"Muna Oqal,&nbsp;Mohanad Odeh,&nbsp;Rawan Abudalu,&nbsp;Abdelrahim Alqudah,&nbsp;Roaa Alnajjar,&nbsp;Yazeed Bani Younes,&nbsp;Maram Al-Shawabkeh,&nbsp;Luma Taha","doi":"10.2144/fsoa-2022-0051","DOIUrl":"https://doi.org/10.2144/fsoa-2022-0051","url":null,"abstract":"<p><strong>Aim: </strong>This study aimed to identify the perspective knowledge, attitudes, and barriers of community pharmacists in promoting breast cancer health.</p><p><strong>Methods: </strong>An internet-based self-administrated questionnaire was distributed using social media groups to the community pharmacists in Jordan.</p><p><strong>Results: </strong>A 76.7% of the pharmacists had insufficient knowledge score of breast cancer and 92.7% had positive attitude. Access to breast cancer educational materials was the major barrier to pharmacists. A significant association was found between pharmacists' knowledge and breast cancer educational materials being given to patients (p < 0.001).</p><p><strong>Conclusion: </strong>Despite the low breast cancer knowledge score and stated barriers that could prevent actualizing community pharmacists' role, they had positive attitude toward educating patients about breast cancer health.</p>","PeriodicalId":12568,"journal":{"name":"Future Science OA","volume":"8 10","pages":"FSO826"},"PeriodicalIF":2.5,"publicationDate":"2022-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9979115/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9100205","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Colonic tuberculosis: a case report. 结肠结核1例。
IF 2.5
Future Science OA Pub Date : 2022-12-01 DOI: 10.2144/fsoa-2022-0056
Ghada Gharbi, Moufida Mahmoudi, Manel Yakoubi, Asma Ben Mohamed, Amal Khsiba, Mohamed Karim M'Farrej, Mahdi Bouassida, Emna Chelbi, Lamine Hamzaoui
{"title":"Colonic tuberculosis: a case report.","authors":"Ghada Gharbi,&nbsp;Moufida Mahmoudi,&nbsp;Manel Yakoubi,&nbsp;Asma Ben Mohamed,&nbsp;Amal Khsiba,&nbsp;Mohamed Karim M'Farrej,&nbsp;Mahdi Bouassida,&nbsp;Emna Chelbi,&nbsp;Lamine Hamzaoui","doi":"10.2144/fsoa-2022-0056","DOIUrl":"https://doi.org/10.2144/fsoa-2022-0056","url":null,"abstract":"<p><strong>Aim: </strong>Colonic tuberculosis is rare. It accounts for 2-3% of abdominal tuberculosis. Clinical, radiological and endoscopic features are nonspecific. The diagnosis must be considered in front of chronic abdominal pain, vesperal fever and weight loss with on colonoscopy the presence of nodules or ulcers. The diagnosis is made on pathological findings.</p><p><strong>Case report: </strong>We report a case of an 82-year-old female patient with the diagnosis of colonic tuberculosis. The diagnosis were suspected on clinical presentation: chronic abdominal pain, fever and weight loss. The colonoscopy showed a nodular aspect of the left and sigmoid colonic mucosa and the pathology examination of the multiple biopsy specimens showed an epithelioid and gigantocellular granulomas with caseous necrosis.</p><p><strong>Conclusion: </strong>In front of a nonspecific clinical and endoscopic aspects, multiples colonic biopsies are mandatory to rule out differential diagnosis and confirm colonic tuberculosis.</p>","PeriodicalId":12568,"journal":{"name":"Future Science OA","volume":"8 10","pages":"FSO830"},"PeriodicalIF":2.5,"publicationDate":"2022-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9979145/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9100204","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Prognostic significance of the angiopoietin-2 for early prediction of septic shock in severe sepsis patients. 血管生成素-2对严重脓毒症患者脓毒性休克早期预测的预后意义。
IF 2.5
Future Science OA Pub Date : 2022-12-01 DOI: 10.2144/fsoa-2022-0077
Luu Thi Thanh Duyen, Bui Van Manh, Tran Thi Phuong Thao, Le Van Khanh, Bui Ngoc Linh Trang, Ngo Truong Giang, Ha Van Quang, Nguyen Thanh Viet, Ngo Thu Hang, Can Van Mao, Nguyen Linh Toan, Hoang Van Tong
{"title":"Prognostic significance of the angiopoietin-2 for early prediction of septic shock in severe sepsis patients.","authors":"Luu Thi Thanh Duyen,&nbsp;Bui Van Manh,&nbsp;Tran Thi Phuong Thao,&nbsp;Le Van Khanh,&nbsp;Bui Ngoc Linh Trang,&nbsp;Ngo Truong Giang,&nbsp;Ha Van Quang,&nbsp;Nguyen Thanh Viet,&nbsp;Ngo Thu Hang,&nbsp;Can Van Mao,&nbsp;Nguyen Linh Toan,&nbsp;Hoang Van Tong","doi":"10.2144/fsoa-2022-0077","DOIUrl":"https://doi.org/10.2144/fsoa-2022-0077","url":null,"abstract":"<p><strong>Aim: </strong>The current study investigated the plasma levels of angiopoietin-1/-2 and their association with clinical outcomes of sepsis.</p><p><strong>Methods: </strong>Angiopoietin-1 and -2 levels were quantified in plasma from 105 patients with severe sepsis by ELISA.</p><p><strong>Results: </strong>Angiopoietin-2 levels elevated according to the severity of sepsis progression. Angiopoietin-2 levels were correlated with mean arterial pressure and platelets counts, total bilirubin, creatinine, procalcitonin, lactate levels and SOFA score. Angiopoietin-2 levels accurately discriminated for sepsis with an AUC = 0.97 and septic shock from severe sepsis patients (AUC = 0.778).</p><p><strong>Conclusion: </strong>Plasma angiopoietin-2 levels may serve as an additional biomarker for severe sepsis and septic shock.</p>","PeriodicalId":12568,"journal":{"name":"Future Science OA","volume":"8 10","pages":"FSO825"},"PeriodicalIF":2.5,"publicationDate":"2022-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9979161/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9394844","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Management and outcomes of advanced hemangioendothelioma at a medical oncology clinic in an Indian tertiary care center. 在印度三级保健中心的医学肿瘤诊所的晚期血管内皮瘤的管理和结果。
IF 2.5
Future Science OA Pub Date : 2022-12-01 DOI: 10.2144/fsoa-2021-0132
Ghazal Tansir, Sameer Rastogi, Adarsh Barwad, Rajni Yadav, Shamim Ahmed Shamim, Ekta Dhamija, Rambha Pandey, Rakesh Garg, Shakti Shrivastava
{"title":"Management and outcomes of advanced hemangioendothelioma at a medical oncology clinic in an Indian tertiary care center.","authors":"Ghazal Tansir,&nbsp;Sameer Rastogi,&nbsp;Adarsh Barwad,&nbsp;Rajni Yadav,&nbsp;Shamim Ahmed Shamim,&nbsp;Ekta Dhamija,&nbsp;Rambha Pandey,&nbsp;Rakesh Garg,&nbsp;Shakti Shrivastava","doi":"10.2144/fsoa-2021-0132","DOIUrl":"https://doi.org/10.2144/fsoa-2021-0132","url":null,"abstract":"<p><strong>Aim: </strong>Hemangioendotheliomas (HEs) are malignant vascular tumors with sparse descriptions in literature owing to their rarity.</p><p><strong>Study design: </strong>Ours is a retrospective study among patients of advanced HEs registered between September 2015 and April 2021.</p><p><strong>Results: </strong>There were 13 patients with median age 34.6 (range: 4-69 years), male preponderance (69%) and predominant subtype of epithelioid HE (76.9%). Common primary sites were viscera (46.2%) and bone (30.8%). Tyrosine kinase inhibitors (TKIs) yielded objective responses in 30% patients whereas chemotherapy only produced disease stabilization in 7.7%.</p><p><strong>Conclusion: </strong>We recognize an aggressive subset of HEs with manifestations such as acute liver failure and splenic rupture. Currently no biomarkers predict the efficacy of TKIs over chemotherapy; however, TKIs showed promising outcomes in this series.</p>","PeriodicalId":12568,"journal":{"name":"Future Science OA","volume":"8 10","pages":"FSO827"},"PeriodicalIF":2.5,"publicationDate":"2022-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9979162/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9394848","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Osteopetrosis: a rare case of portal hypertension. 门脉高压致骨质疏松1例。
IF 2.5
Future Science OA Pub Date : 2022-11-15 eCollection Date: 2022-09-01 DOI: 10.2144/fsoa-2022-0028
Amal Khsiba, Sahar Nasr, Lamine Hamzaoui, Moufida Mahmoudi, Asma Ben Mohamed, Manel Yaakoubi, Mouna Medhioub, Mohamed Moussadek Azouz
{"title":"Osteopetrosis: a rare case of portal hypertension.","authors":"Amal Khsiba,&nbsp;Sahar Nasr,&nbsp;Lamine Hamzaoui,&nbsp;Moufida Mahmoudi,&nbsp;Asma Ben Mohamed,&nbsp;Manel Yaakoubi,&nbsp;Mouna Medhioub,&nbsp;Mohamed Moussadek Azouz","doi":"10.2144/fsoa-2022-0028","DOIUrl":"https://doi.org/10.2144/fsoa-2022-0028","url":null,"abstract":"<p><p>Osteopetrosis is a rare genetic bone disorder characterized by a defect in osteoclasts recruitment and function. Its manifestations are numerous and they mainly include skeletal and dental deformities, cranial nerve entrapment and infections. Over time, osteoclastic expansion invades bone marrow leaving little space for hematopoietic cells. As a result, extramedullary hematopoiesis takes place in the reticular system mainly in the spleen and liver. In these patients, portal hypertension can occur as a result of extramedullary hematopoiesis associated splenomegaly. We are reporting in this article a rare case of spontaneous bacterial peritonitis associated with portal hypertension in a patient with osteopetrosis.</p>","PeriodicalId":12568,"journal":{"name":"Future Science OA","volume":"8 8","pages":"FSO817"},"PeriodicalIF":2.5,"publicationDate":"2022-11-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9704036/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40569000","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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