Future Science OA最新文献_第10页

A biochemical and histopathological analysis of spirulina's effect on liver and kidney function in male rats. 螺旋藻对雄性大鼠肝肾功能影响的生化及组织病理学分析。

IF 2.5

Future Science OA Pub Date : 2026-12-01 Epub Date: 2026-10-01 DOI: 10.1080/20565623.2025.2563488

Amani Layth Hameed, Muhamed Aydin Abbas, Feedan Tahseen Mohammed Halmi, Ligia Eliya Matti Shemiss, Sahar Mohammed Zaki Abdullah, Suzan Niyazi Anwer Alamdar, Miran Diyar Salahaddin, Anfal Shakir Motib, Harem Khdir Awla, Shukur Wasman Smail, Kawa Amin

{"title":"A biochemical and histopathological analysis of spirulina's effect on liver and kidney function in male rats.","authors":"Amani Layth Hameed, Muhamed Aydin Abbas, Feedan Tahseen Mohammed Halmi, Ligia Eliya Matti Shemiss, Sahar Mohammed Zaki Abdullah, Suzan Niyazi Anwer Alamdar, Miran Diyar Salahaddin, Anfal Shakir Motib, Harem Khdir Awla, Shukur Wasman Smail, Kawa Amin","doi":"10.1080/20565623.2025.2563488","DOIUrl":"10.1080/20565623.2025.2563488","url":null,"abstract":"Background: Spirulina contains a variety of biological molecules including protein, lipids, vitamins, minerals, and colors. Spirulina can aid in the prevention and management of certain metabolic disorders such as diabetes, heart disease, and hyperglycemia.Aim: The objective of this study is to determine adverse effects of two doses (1000 and 1500 mg/kg body weight) of supplemental spirulina on liver and kidneys in vivo.Material and methods: Three groups of adult male albino rats weighing 150-200 g were created: G1 was the control group; G2 received a spirulina treatment at a dose of 1000 mg/kg body weight; and G3 received a spirulina treatment at a dose of 1500 mg/kg body weight. Rats were orally administered spirulina supplement for 28 d. Biochemical analysis was performed to determine liver and kidney function by measuring the serum levels of ALT, AST, ALP, urea, and creatinine. The liver and kidney were dissected for histopathological examination.Result: Spirulina caused biochemical changes and histopathological alterations in liver and kidney tissue in dose-dependent manner.Conclusion: Administering excessive amounts of Spirulina without supervision might lead to biochemical disturbances and pathological alterations in vital organs. Thus, utilizing spirulina as a dietary supplement needs to be taken with prudence.","PeriodicalId":12568,"journal":{"name":"Future Science OA","volume":"12 1","pages":"2563488"},"PeriodicalIF":2.5,"publicationDate":"2026-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13641554/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149107982","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Functional thiamine deficiency in patients with chronic kidney disease in Northeast Thailand. 泰国东北部慢性肾病患者功能性硫胺素缺乏症

IF 2.5

Future Science OA Pub Date : 2026-12-01 Epub Date: 2026-10-09 DOI: 10.1080/20565623.2026.2738750

Kanokwan Nahok, Chalongchai Chalermwat, Ubon Cha'on, Apinya Jusakul, Patcharee Boonsiri, Angkor Chamdam, Ratthaphol Kraiklang, Patcharaporn Tippayawat, Sirirat Anutrakulchai, Worachart Lert-Itthiporn

{"title":"Functional thiamine deficiency in patients with chronic kidney disease in Northeast Thailand.","authors":"Kanokwan Nahok, Chalongchai Chalermwat, Ubon Cha'on, Apinya Jusakul, Patcharee Boonsiri, Angkor Chamdam, Ratthaphol Kraiklang, Patcharaporn Tippayawat, Sirirat Anutrakulchai, Worachart Lert-Itthiporn","doi":"10.1080/20565623.2026.2738750","DOIUrl":"10.1080/20565623.2026.2738750","url":null,"abstract":"Background: Patients with chronic kidney disease (CKD) may be vulnerable to thiamine insufficiency due to dietary restrictions, altered metabolism, and renal replacement therapy. We aimed to determine the prevalence of functional thiamine deficiency, its distribution across CKD stages, and the associated clinical factors in a Thai population.Areas covered: Thiamine status was assessed in red blood cells using the erythrocyte transketolase activity coefficient (ETKAC) assay. Participants (n = 605) were categorized as having normal thiamine status (ETKAC ≤1.25) or functional thiamine deficiency (ETKAC >1.25). The prevalence of functional thiamine deficiency was 6.1% overall and 6.4% among participants with CKD. Univariate analyses of participants with CKD showed that higher systolic blood pressure (SBP), hypertension, and lower estimated glomerular filtration rate (eGFR) were associated with functional thiamine deficiency. In the multivariable analysis adjusted for age, sex, SBP, eGFR, and alcohol intake, hypertension remained independently associated with functional thiamine deficiency (β = 2.202; 95% confidence interval (CI) for the corresponding odds ratio (OR): 2.311-35.383; p = 0.002).Expert opinion/commentary: Functional thiamine deficiency was observed in a subset of participants, particularly in patients with CKD and hypertension, supporting further investigation of thiamine status in CKD populations.","PeriodicalId":12568,"journal":{"name":"Future Science OA","volume":"12 1","pages":"2738750"},"PeriodicalIF":2.5,"publicationDate":"2026-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13656806/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149136164","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

TOMM5 is associated with oral cancer progression: a multi-omics analysis from single-cell atlas to in vitro validation. TOMM5与口腔癌进展相关：从单细胞图谱到体外验证的多组学分析

IF 2.5

Future Science OA Pub Date : 2026-12-01 Epub Date: 2026-10-13 DOI: 10.1080/20565623.2026.2741252

Li Gao, Jian-Di Li, Yi-Yang Chen, Ge-Li Tan, Jian-Jia Zeng, Xi Lin, Lu Liang, Shuang Xia, Guo-Jiao Wu, Gang Chen

{"title":"TOMM5 is associated with oral cancer progression: a multi-omics analysis from single-cell atlas to in vitro validation.","authors":"Li Gao, Jian-Di Li, Yi-Yang Chen, Ge-Li Tan, Jian-Jia Zeng, Xi Lin, Lu Liang, Shuang Xia, Guo-Jiao Wu, Gang Chen","doi":"10.1080/20565623.2026.2741252","DOIUrl":"10.1080/20565623.2026.2741252","url":null,"abstract":"Aims: Translocase of Outer Mitochondrial Membrane 5 (TOMM5), a mitochondrial outer membrane translocase subunit implicated in tumorigenesis, remains unexplored in oral cancer. Herein, we aimed to decipher the role of TOMM5 in oral cancer.Methods: This study comprehensively explored the expression profile, clinical significance, and functional roles of TOMM5 in oral carcinogenesis with global RNA-seq and microarray datasets. In vitro experiments were performed for evaluating the impact of TOMM5 knockdown on the biological functions of oral cancer cells. Distribution heterogeneity of TOMM5 expression and related cellular trajectory was analyzed through scRNA-seq. The therapeutic implications of TOMM5 for oral cancer were analyzed through drug sensitivity prediction and tumor immune dysfunction and exclusion (TIDE) scoring.Results: TOMM5 was significantly overexpressed in oral cancer tissues and demonstrated moderate diagnostic accuracy. TOMM5 knockdown significantly suppressed aggressive biological behaviors of oral cancer cells. ScRNA-seq data revealed predominant TOMM5 expression in B cells, decreasing with differentiation, and linked distinct pathway activities to specific cellular compartments. High TOMM5 expression was linked to reduced immune cell infiltration and sensitivity to Paclitaxel/Vincristine.Conclusions: Overexpressed TOMM5 shows potential as a biomarker in oral cancer, correlating with tumor progression and immune infiltration.","PeriodicalId":12568,"journal":{"name":"Future Science OA","volume":"12 1","pages":"2741252"},"PeriodicalIF":2.5,"publicationDate":"2026-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13671447/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149180732","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Clinicohistopathological characteristics of renal cell carcinoma in Jordan. 约旦肾细胞癌的临床组织病理学特征。

IF 2.1

Future Science OA Pub Date : 2026-12-01 Epub Date: 2025-12-17 DOI: 10.1080/20565623.2025.2601636

Mohammad Al-Zubi, Rana Haddad, Ammar Badr, Hayat Al Bibi, Saif Azzam, Mohammad Araydah, Ahmed Al Sharie, Karis Khattab, Hussein Qasim, Sarah Al Sharie

{"title":"Clinicohistopathological characteristics of renal cell carcinoma in Jordan.","authors":"Mohammad Al-Zubi, Rana Haddad, Ammar Badr, Hayat Al Bibi, Saif Azzam, Mohammad Araydah, Ahmed Al Sharie, Karis Khattab, Hussein Qasim, Sarah Al Sharie","doi":"10.1080/20565623.2025.2601636","DOIUrl":"10.1080/20565623.2025.2601636","url":null,"abstract":"Background: Renal cell carcinoma (RCC) is the most common adult kidney malignancy, yet regional data from the Middle East are limited. This study characterized the clinicopathological, immunohistochemical, and survival features of RCC in a Jordanian cohort.Methods: A retrospective analysis of 295 RCC cases (2020-2024) from Yarmouk University affiliated hospitals was conducted. Clinical and pathological parameters, immunohistochemical markers, and survival were analyzed using Kaplan-Meier and log-rank tests.Results: Clear-cell RCC was the predominant subtype (72.2%), followed by papillary (10.5%), chromophobe (9.1%), and others (8.1%). The mean age was 62.1 years, with male predominance (66.4%). Clear-cell RCC showed higher rates of high-grade histology, sarcomatoid and rhabdoid differentiation, capsule invasion, renal vein involvement, and metastasis (p < 0.05), while chromophobe RCC was indolent with no metastases. CK7, Hale's iron, and c-kit characterized chromophobe RCC, vimentin was typical of clear-cell, and AMACR of papillary RCC. Survival was significantly worse with older age, higher T stage, sarcomatoid features, and higher ISUP grade, while nephrectomy type had no effect.Conclusions: Clear-cell RCC demonstrated aggressive pathology, whereas chromophobe RCC was indolent. Age, subtype, stage, and sarcomatoid features were key prognostic factors, highlighting the need for early detection and expanded nephron-sparing surgery in the region.","PeriodicalId":12568,"journal":{"name":"Future Science OA","volume":"12 1","pages":"2601636"},"PeriodicalIF":2.1,"publicationDate":"2026-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12716033/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145767908","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Medical progress, relaxed natural selection, and adolescent obesity: implications for global health. 医学进步、宽松的自然选择和青少年肥胖：对全球健康的影响。

IF 2.1

Future Science OA Pub Date : 2026-12-01 Epub Date: 2025-12-17 DOI: 10.1080/20565623.2025.2602337

Wenpeng You, Maciej Henneberg

{"title":"Medical progress, relaxed natural selection, and adolescent obesity: implications for global health.","authors":"Wenpeng You, Maciej Henneberg","doi":"10.1080/20565623.2025.2602337","DOIUrl":"10.1080/20565623.2025.2602337","url":null,"abstract":"Objective: To examine the role of relaxed natural selection, measured using the Henneberg Index (Ibs), in influencing adolescent obesity prevalence across 191 countries.Methods: Population-level variables, including adolescent obesity prevalence, Ibs (Henneberg Index), GDP PPP, urbanization, and calorie intake, were obtained from United Nations sources. The relationship between the Henneberg Index and adolescent obesity was analyzed using curvilinear and linear regression models with raw and log-transformed data to address non-homoscedasticity. Regional correlations were explored by grouping countries.Results: A significant correlation (r∼0.5) between the Henneberg Index and adolescent obesity was found and remained consistent through third-order polynomial regression and partial correlations after adjusting for GDP PPP, urbanization, and calorie intake. The correlation was stronger in developing countries compared to developed ones. Stepwise multiple regression analysis identified the Henneberg Index as the second most significant predictor of adolescent obesity, following GDP PPP. Calorie intake did not significantly predict adolescent obesity in the models.Conclusions: Reduced natural selection, facilitated by medical practices allowing individuals with obesity-linked traits to reproduce, may contribute to the population-level accumulation of these traits, increasing adolescent obesity. These findings underscore the need to consider evolutionary and genetic factors alongside environmental and socioeconomic determinants in developing obesity prevention strategies.","PeriodicalId":12568,"journal":{"name":"Future Science OA","volume":"12 1","pages":"2602337"},"PeriodicalIF":2.1,"publicationDate":"2026-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12716050/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145767854","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Global technological trends in sustainable antimicrobial surface formulations: a patent-based review for cleaner healthcare environments. 可持续抗菌表面配方的全球技术趋势：清洁医疗环境的专利审查。

IF 2.5

Future Science OA Pub Date : 2026-12-01 Epub Date: 2026-06-05 DOI: 10.1080/20565623.2026.2674959

Luana Conte Nunes, Stéfanno Souza Santos, Luana Rossato, Izabel Almeida Alves, Edith Cristina Laignier Cazedey

{"title":"Global technological trends in sustainable antimicrobial surface formulations: a patent-based review for cleaner healthcare environments.","authors":"Luana Conte Nunes, Stéfanno Souza Santos, Luana Rossato, Izabel Almeida Alves, Edith Cristina Laignier Cazedey","doi":"10.1080/20565623.2026.2674959","DOIUrl":"10.1080/20565623.2026.2674959","url":null,"abstract":"Introduction: Healthcare-associated infections (HAIs) are a global challenge, exacerbated by multidrug-resistant pathogens. This study systematically maps antimicrobial surface formulations (1995-2024), analyzing gaps in regulatory readiness, toxicological validation, and sustainability.Areas covered: Using the Espacenet database and PRISMA guidelines, 49 patents were analyzed. Innovation surged post-2015, led by private corporations (72.09%) in the USA, Canada, and China (67.35%). Synthetic actives, primarily quaternary ammonium compounds, dominated (71.43%), while natural (16.33%) and hybrid (10.20%) approaches were less frequent. Key targets included S. aureus, K. pneumoniae, and E. coli. Although 38.77% of patents claimed sustainability (biodegradability/low toxicity), only 40.82% disclosed mechanisms of action, and 34.69% provided toxicological data.Expert opinion: A significant gap exists between technological innovation and regulatory/safety validation. Future developments must integrate life-cycle assessments and robust toxicological testing. Harmonized regulatory pathways and public-private partnerships are essential to translate these innovations into scalable, sustainable, and safer disinfectant solutions for healthcare environments.","PeriodicalId":12568,"journal":{"name":"Future Science OA","volume":"12 1","pages":"2674959"},"PeriodicalIF":2.5,"publicationDate":"2026-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13245061/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148162770","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Clinical immunogenicity and pharmacokinetic assessments of E3112, a recombinant human hepatocyte growth factor. 重组人肝细胞生长因子E3112的临床免疫原性和药代动力学评价

IF 2.5

Future Science OA Pub Date : 2026-12-01 Epub Date: 2026-07-04 DOI: 10.1080/20565623.2026.2696881

Muneo Aoyama, Toshiyuki Takanohashi, Fuminori Ohba, Yuji Mano

{"title":"Clinical immunogenicity and pharmacokinetic assessments of E3112, a recombinant human hepatocyte growth factor.","authors":"Muneo Aoyama, Toshiyuki Takanohashi, Fuminori Ohba, Yuji Mano","doi":"10.1080/20565623.2026.2696881","DOIUrl":"10.1080/20565623.2026.2696881","url":null,"abstract":"Aims: E3112 is a recombinant human hepatocyte growth factor (HGF) intended for the treatment of acute liver failure. As the presence of anti-drug antibody (ADA) against E3112 could pose a significant risk in clinical settings if it cross-reacts with the body's natural HGF, we have developed assays for E3112 and its ADA in human serum.Methods: Assays of E3112 and its ADA developed by ligand binding assays were validated in accordance with bioanalytical guidelines and applied to clinical pharmacokinetic (PK) and immunogenicity assessments.Results: These assays demonstrated the ability to detect E3112 at a concentration as low as 0.156 ng/mL, whereas the sensitivity of ADA was determined to be 42.3 ng/mL. The validation studies, incorporating quality control for the PK assay and positive control of ADA, substantiated the reproducibility of the assays. The ADA and PK assays were applied to the real sample assays supporting a clinical trial of E3112. Following the intravenous administration of E3112, serum E3112 levels declined with a half-life of 19.3 h. No ADA was detected in predose or postdose samples.Conclusion: These findings collectively indicate that E3112 exhibited a favorable PK profile with minimal immunogenicity within the clinical context.","PeriodicalId":12568,"journal":{"name":"Future Science OA","volume":"12 1","pages":"2696881"},"PeriodicalIF":2.5,"publicationDate":"2026-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13349028/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148387548","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Predictors of spontaneous bacterial peritonitis among cirrhotic patients with ascites in Dodoma, Tanzania: a cross-sectional study. 坦桑尼亚Dodoma肝硬化腹水患者自发性细菌性腹膜炎的预测因素：一项横断面研究。

IF 2.5

Future Science OA Pub Date : 2026-12-01 Epub Date: 2026-03-10 DOI: 10.1080/20565623.2026.2639037

Emmanuel Marcel Sindato, Salum Ali Mwinyi, James Joseph Yahaya

{"title":"Predictors of spontaneous bacterial peritonitis among cirrhotic patients with ascites in Dodoma, Tanzania: a cross-sectional study.","authors":"Emmanuel Marcel Sindato, Salum Ali Mwinyi, James Joseph Yahaya","doi":"10.1080/20565623.2026.2639037","DOIUrl":"10.1080/20565623.2026.2639037","url":null,"abstract":"Introduction: Spontaneous bacterial peritonitis (SBP) is a fatal complication which occurs among decompensated cirrhotic patients which is also associated with high morbidity and mortality. Despite the complications of decompensated cirrhotic patients are common and fatal, there is limited information regarding prevalence and predictors of SBP in Tanzania.Aim: This study aimed to investigate the prevalence and predictors of SBP in cirrhotic patients with ascites.Materials and methods: A prospective cross-sectional study was undertaken in Dodoma city, Tanzania from November 2022 to June 2023.Results: The present study included a total of 269 patients with median age of 46.0 (IQR = 39.0-53.0) years. The prevalence of SBP in this study was (19.0%, n = 51). Child-Pugh score C, international normalized ratio (>1.5 ± 0.3), and severe ascites were the independent predictors (factors) associated with SBP in this study.Conclusions: The findings of this study indicate that SBP is a health problem of concern among cirrhotic patients. Factors including Child-Pugh C and raised international normalized ratio have shown ability to strongly predict the diagnosis of SBP, and therefore, such factors may be used to stratify cirrhotic patients into high risk and low risk cirrhotic patients for SBP.","PeriodicalId":12568,"journal":{"name":"Future Science OA","volume":"12 1","pages":"2639037"},"PeriodicalIF":2.5,"publicationDate":"2026-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12987509/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147432224","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The potential of plant-derived exosome-like nanovesicles from Centella asiatica leaves (CA-PDENs) for anti-inflammation and prevention of UVB-induced photoaging. 积雪草叶片植物源性外泌体样纳米囊泡（ca - ptens）抗炎症和预防uvb诱导的光老化的潜力

IF 2.5

Future Science OA Pub Date : 2026-12-01 Epub Date: 2026-04-11 DOI: 10.1080/20565623.2026.2654777

Anggraini Barlian, Youngkwan Cho, Yulia Rahmah, Annisa Nurrahmi Az Zahra, Hanifa Azka Maulidisya, Noviana Vanawati, Safira Meidina Nursatya

{"title":"The potential of plant-derived exosome-like nanovesicles from Centella asiatica leaves (CA-PDENs) for anti-inflammation and prevention of UVB-induced photoaging.","authors":"Anggraini Barlian, Youngkwan Cho, Yulia Rahmah, Annisa Nurrahmi Az Zahra, Hanifa Azka Maulidisya, Noviana Vanawati, Safira Meidina Nursatya","doi":"10.1080/20565623.2026.2654777","DOIUrl":"10.1080/20565623.2026.2654777","url":null,"abstract":"Aims: This study aimed to isolate plant-derived exosome-like nanovesicles from Centella asiatica leaves (CA-PDENs) and evaluate their anti-inflammatory and anti-photoaging potential.Materials & methods: CA-PDENs were isolated via differential centrifugation and polyethylene glycol (PEG) precipitation, then characterized physically and proteomically Anti-inflammatory effects were assessed in lipopolysaccharide (LPS)-stimulated RAW 264.7 macrophages. Anti-Photoaging potential was evaluated in ultraviolet B (UVB)-induced 1BR3 fibroblasts. Antibacterial activity against Cutibacterium acnes was also evaluated.Results: CA-PDENs are homogenous, spherical vesicles containing metabolite biosynthesis enzymes. They showed no cytotoxicity and were efficiently internalized. Functionally, CA-PDENs significantly suppressed nitric oxide production, indicating pronounced early-phase anti-inflammatory activity, while CD80, CD206, and interleukin-6 (IL-6) modulation showed consistent but non-significant trends. In fibroblasts, CA-PDENs exhibited strong antioxidant activity, reduced intracellular reactive oxygen species (ROS), attenuated collagen degradation, and enhanced wound closure. Moderate antibacterial activity was also observed.Conclusions: CA-PDENs possess robust anti-inflammatory and photoprotective properties, supporting their potential as multifunctional nanocosmetic ingredients.","PeriodicalId":12568,"journal":{"name":"Future Science OA","volume":"12 1","pages":"2654777"},"PeriodicalIF":2.5,"publicationDate":"2026-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13078216/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147653989","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Longitudinal assessment of metabolic and neurological decline in peripheral polyneuropathy over ten years. 十多年来周围多发性神经病代谢和神经功能下降的纵向评估。

IF 2.5

Future Science OA Pub Date : 2026-12-01 Epub Date: 2026-05-04 DOI: 10.1080/20565623.2026.2665758

Dinara Azizkhojayeva, Gulnaz Nuskabayeva, Karlygash Sadykova, Ainur Turmanbayeva, Dana Kaldarkhan, Nurlybek Mombekov, Nigara Yerkhojayeva, Malika Raimova, Umida Yodgarova, Saodat Sobirova, Kamshat Madenbay, Ainash Oshibayeva

{"title":"Longitudinal assessment of metabolic and neurological decline in peripheral polyneuropathy over ten years.","authors":"Dinara Azizkhojayeva, Gulnaz Nuskabayeva, Karlygash Sadykova, Ainur Turmanbayeva, Dana Kaldarkhan, Nurlybek Mombekov, Nigara Yerkhojayeva, Malika Raimova, Umida Yodgarova, Saodat Sobirova, Kamshat Madenbay, Ainash Oshibayeva","doi":"10.1080/20565623.2026.2665758","DOIUrl":"10.1080/20565623.2026.2665758","url":null,"abstract":"Aims: This research aims to evaluate changes in metabolic status and the development of peripheral polyneuropathy (PN) in Kazakhstan.Methods: This longitudinal observational study followed a cohort of adults with metabolic syndrome, comparing clinical, biochemical, and neurophysiological parameters between baseline (2014) and follow-up (2024). A total of 213 out of the original 570 participants were reexamined, with standardized assessments including anthropometry, blood tests, and electroneuromyography.Results: Over the observation period, normoglycemic participants decreased from 67% to 54% while prediabetic participants increased from 17% to 37% (p < 0.001). The average BMI of participants increased from 27.8 to 29.3 kg/m2, and the prevalence of abdominal obesity rose from 72% to 85% (p < 0.001). At the 10-year follow-up, polyneuropathy was identified in 28% of participants, who totaled 60 individuals. The research found that diabetes created a nine times higher risk of PN development (OR = 9.23, p < 0.001), and BMI and waist circumference measurements also were associated with increased odds of PN at follow-up.Conclusion: Adverse metabolic profiles were associated with the presence of polyneuropathy at the 10-year follow-up, including among individuals without overt diabetes. These findings highlight the importance of metabolic risk factors management to reduce the burden of PN.","PeriodicalId":12568,"journal":{"name":"Future Science OA","volume":"12 1","pages":"2665758"},"PeriodicalIF":2.5,"publicationDate":"2026-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13154949/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147836835","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0