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Assessment of histology's performance compared with PCR in the diagnosis of Helicobacter pylori infection. 评估组织学与 PCR 在幽门螺旋杆菌感染诊断中的性能比较。
IF 2.5
Future Science OA Pub Date : 2024-05-14 eCollection Date: 2024-01-01 DOI: 10.2144/fsoa-2023-0217
Manel Moalla, Lassaad Chtourou, Basma Mnif, Slim Charfi, Hend Smaoui, Mon Boudabous, Leila Mnif, Ali Amouri, Hela Gdoura, Adnene Hammami, Tahya Boudawara, Nabil Tahri
{"title":"Assessment of histology's performance compared with PCR in the diagnosis of <i>Helicobacter pylori</i> infection.","authors":"Manel Moalla, Lassaad Chtourou, Basma Mnif, Slim Charfi, Hend Smaoui, Mon Boudabous, Leila Mnif, Ali Amouri, Hela Gdoura, Adnene Hammami, Tahya Boudawara, Nabil Tahri","doi":"10.2144/fsoa-2023-0217","DOIUrl":"10.2144/fsoa-2023-0217","url":null,"abstract":"<p><p><b>Aim:</b> Histology is the most widely used test to detect <i>H. pylori</i>. PCR is less used but allows the detection of both infection and antibiotics' resistance. <b>Methods:</b> We conducted a monocentric cross-sectional study, collecting 97 symptomatic patients to assess the diagnostic performance of histology in the detection of <i>H. pylori</i> infection compared with PCR. <b>Results:</b> Sensitivity of histology in comparison with PCR was 81.5% and specificity was 56.3%. A history of anti-<i>H. pylori</i> therapy intake, as well as the density of the bacterium on the gastric sample and the presence of gastric atrophy, were significantly correlated to the PCR's result in terms of <i>H. pylori</i> detection. <b>Conclusion:</b> Thus, histology can be considered as an efficient test compared with PCR in <i>H. pylori</i> detection.</p>","PeriodicalId":12568,"journal":{"name":"Future Science OA","volume":"10 1","pages":"FSO976"},"PeriodicalIF":2.5,"publicationDate":"2024-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11137788/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141179421","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Unleashing light's healing power: an overview of photobiomodulation for Alzheimer's treatment 释放光的治疗力量：光生物调制治疗老年痴呆症概述
IF 2.5
Future Science OA Pub Date : 2024-01-11 DOI: 10.2144/fsoa-2023-0155
Aakash Ramanishankar, Ankul Singh S, Rukaiah F Begum, Narayanan Jayasankar, Afreen Nayeem, B. Prajapati, Shanmugasundaram Nirenjen
{"title":"Unleashing light's healing power: an overview of photobiomodulation for Alzheimer's treatment","authors":"Aakash Ramanishankar, Ankul Singh S, Rukaiah F Begum, Narayanan Jayasankar, Afreen Nayeem, B. Prajapati, Shanmugasundaram Nirenjen","doi":"10.2144/fsoa-2023-0155","DOIUrl":"https://doi.org/10.2144/fsoa-2023-0155","url":null,"abstract":"Aim: Photobiomodulation involves the use of low-level light therapy or near-infrared light therapy found to be useful in the treatment of a wide range of neurological diseases. Objective: The aim is to review the mechanism and clinical applications of photobiomodulation therapy (PBMT) in managing Alzheimer's disease. Methods: To ensure that the consensus statement accurately reflects both the experts' viewpoint and the most recent developments in the field, the expert opinions were recorded and thoroughly reviewed. Results: PBMT elicits reduction of beta-amyloid plaque, restoration of mitochondrial function, anti-inflammatory and antioxidant properties with a stimulation in ATP synthesis. Conclusion: The PBMT could be helpful in patients non-responsive to traditional pharmacological therapy providing significant aid in the management of Alzheimer's disease when introduced into the medical field.","PeriodicalId":12568,"journal":{"name":"Future Science OA","volume":"1 1","pages":""},"PeriodicalIF":2.5,"publicationDate":"2024-01-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139438625","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
SARS-CoV-2-induced phosphorylation and its pharmacotherapy backed by artificial intelligence and machine learning 由人工智能和机器学习支持的 SARS-CoV-2 诱导的磷酸化及其药物疗法
IF 2.5
Future Science OA Pub Date : 2024-01-10 DOI: 10.2144/fsoa-2023-0112
Fouzia Qamar, Zubair Sharif, J. Idrees, Asif Wasim, Sana Haider, Saad Salman
{"title":"SARS-CoV-2-induced phosphorylation and its pharmacotherapy backed by artificial intelligence and machine learning","authors":"Fouzia Qamar, Zubair Sharif, J. Idrees, Asif Wasim, Sana Haider, Saad Salman","doi":"10.2144/fsoa-2023-0112","DOIUrl":"https://doi.org/10.2144/fsoa-2023-0112","url":null,"abstract":"Aims: To investigate the role of phosphorylation in SARS-CoV-2 infection, potential therapeutic targets and its harmful genetic sequences. Materials & Methods: Data mining techniques were employed to identify upregulated kinases responsible for proteomic changes induced by SARS-CoV-2. Spike and nucleocapsid proteins' sequences were analyzed using predictive tools, including SNAP2, MutPred2, PhD-SNP, SNPs&Go, MetaSNP, Predict-SNP and PolyPhen-2. Missense variants were identified using ensemble-based algorithms and homology/structure-based models like SIFT, PROVEAN, Predict-SNP and MutPred-2. Results: Eight missense variants were identified in viral sequences. Four damaging variants were found, with SNPs&Go and PolyPhen-2. Promising therapeutic candidates, including gilteritinib, pictilisib, sorafenib, RO5126766 and omipalisib, were identified. Conclusion: This research offers insights into SARS-CoV-2 pathogenicity, highlighting potential treatments and harmful variants in viral proteins.","PeriodicalId":12568,"journal":{"name":"Future Science OA","volume":"4 24","pages":""},"PeriodicalIF":2.5,"publicationDate":"2024-01-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139439835","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
GC-MS analysis of an ethanolic extract of Ocimum species: a network pharmacology analysis insight towards obesity 欧加木乙醇提取物的气相色谱-质谱分析：网络药理学分析对肥胖症的启示
IF 2.5
Future Science OA Pub Date : 2024-01-10 DOI: 10.2144/fsoa-2023-0202
Priyadharshini Gnanamurthy, Manoj K Narasimhan, Sarvesh Sabarathinam
{"title":"GC-MS analysis of an ethanolic extract of Ocimum species: a network pharmacology analysis insight towards obesity","authors":"Priyadharshini Gnanamurthy, Manoj K Narasimhan, Sarvesh Sabarathinam","doi":"10.2144/fsoa-2023-0202","DOIUrl":"https://doi.org/10.2144/fsoa-2023-0202","url":null,"abstract":"Aim: In this study, we have selected two different Ocimum tenuiflorum plants, Ocimum tenuiflorum (Rama tulsi) (OTRT) and Ocimum tenuiflorum (Krishna tulsi) (OTKT). Materials & methods: In the present investigation, ethanol was used as a solvent to estimate the bioactive compounds present in it through gas chromatography-mass spectrometry (GC–MS). Results: Based on the GC-MS data benzenepropanoic acid, 3-methoxy-alpha,4-bis[(trimethylsilyl)oxy was found to be the potent compound in OTRT (MW:428.74 g/mol) and methyl 3-(4-benzyloxy-3,5-dimethoxyphenyl)-2-methylpropanoate in OTKT (MW:342.39 g/mol). To estimate its pharmacological application, an integrated Network Pharmacology approach is performed toward the disease target obesity. Conclusion: From the Protein–Protein interaction from the string database, SRC, BCL2, EGFR, MTOR, CDK1, ERBB2, MAPK1, FYN, AR and MAPK14 are the top-ranked targets.","PeriodicalId":12568,"journal":{"name":"Future Science OA","volume":"8 7","pages":""},"PeriodicalIF":2.5,"publicationDate":"2024-01-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139439094","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Oleuropein impact on colorectal cancer 油菜素对大肠癌的影响
IF 2.5
Future Science OA Pub Date : 2024-01-05 DOI: 10.2144/fsoa-2023-0131
Hamdi Nsairat, Areej M. Jaber, Haya Faddah, Somaya Ahmad
{"title":"Oleuropein impact on colorectal cancer","authors":"Hamdi Nsairat, Areej M. Jaber, Haya Faddah, Somaya Ahmad","doi":"10.2144/fsoa-2023-0131","DOIUrl":"https://doi.org/10.2144/fsoa-2023-0131","url":null,"abstract":"Colorectal cancer (CRC) is considered the third most common cancer in the world. In Mediterranean region, olives and olive oil play a substantial role in diet and medical traditional behaviors. They totally believe that high consumption of olive products can treat a wide range of diseases and decrease risk of illness. Oleuropein is the main active antioxidant molecule found in pre-mature olive fruit and leaves. Recently, it has been demonstrated that oleuropein is used in cancer therapy as an anti-proliferative and apoptotic agent for some cancer cells. In this review, we would like to explore the conclusive effects of oleuropein on CRC with respect to in vitro and in vivo studies.","PeriodicalId":12568,"journal":{"name":"Future Science OA","volume":"34 2","pages":""},"PeriodicalIF":2.5,"publicationDate":"2024-01-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139381725","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Nanopore sensing and machine learning: future of biomarker analysis and disease detection 纳米孔传感和机器学习：生物标记分析和疾病检测的未来
IF 2.5
Future Science OA Pub Date : 2024-01-05 DOI: 10.2144/fsoa-2023-0226
Shankar Dutt, B. Karawdeniya, Yapa Mndy Bandara, Patrick Kluth
{"title":"Nanopore sensing and machine learning: future of biomarker analysis and disease detection","authors":"Shankar Dutt, B. Karawdeniya, Yapa Mndy Bandara, Patrick Kluth","doi":"10.2144/fsoa-2023-0226","DOIUrl":"https://doi.org/10.2144/fsoa-2023-0226","url":null,"abstract":"","PeriodicalId":12568,"journal":{"name":"Future Science OA","volume":"63 16","pages":""},"PeriodicalIF":2.5,"publicationDate":"2024-01-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139381789","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Parents of children with autism spectrum disorder quality of life in Jordan: a comparative study 约旦自闭症谱系障碍儿童家长的生活质量：一项比较研究
IF 2.5
Future Science OA Pub Date : 2023-12-21 DOI: 10.2144/fsoa-2023-0096
Abedallah Kasem, S. Abuhammad, Naemah Jamal
{"title":"Parents of children with autism spectrum disorder quality of life in Jordan: a comparative study","authors":"Abedallah Kasem, S. Abuhammad, Naemah Jamal","doi":"10.2144/fsoa-2023-0096","DOIUrl":"https://doi.org/10.2144/fsoa-2023-0096","url":null,"abstract":"Aim: This study aimed to assess the quality of life (QoL) of parents of children with autism spectrum disorder (ASD) in Jordan and its associated factors. Methods: This comparative study was conducted among parents of children with ASD and non-ASD. Data collection took four setting areas that include three centers for autism in three different municipalities and the control group was collected using social media. A convenience sample of 242 parents agreed to complete a QoL questionnaire. Results: Parents of children with ASD in Jordan have poor QoL across the five domains of QoL in compare with parents with non-ASD child. Factors such as gender, level of education, living condition and employment status were found impacting QoL.","PeriodicalId":12568,"journal":{"name":"Future Science OA","volume":"53 6","pages":""},"PeriodicalIF":2.5,"publicationDate":"2023-12-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138953118","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Squamous cell carcinoma and Crohn's disease: a sometimes-challenging diagnosis 鳞状细胞癌和克罗恩病：有时很棘手的诊断方法
IF 2.5
Future Science OA Pub Date : 2023-12-12 DOI: 10.2144/fsoa-2023-0109
Mona Boudabbous, Baha Barkia, W. Feki, H. Gdoura, L. Chtourou, M. Moalla, L. Mnif, A. Amouri, Zeinab Mnif, N. Tahri
{"title":"Squamous cell carcinoma and Crohn's disease: a sometimes-challenging diagnosis","authors":"Mona Boudabbous, Baha Barkia, W. Feki, H. Gdoura, L. Chtourou, M. Moalla, L. Mnif, A. Amouri, Zeinab Mnif, N. Tahri","doi":"10.2144/fsoa-2023-0109","DOIUrl":"https://doi.org/10.2144/fsoa-2023-0109","url":null,"abstract":"Aim: Non-melanoma skin cancers are more common in people with inflammatory bowel disease. However, these tumors can rarely mimic a cutaneous manifestation of the disease, which delays diagnosis and clouds prognosis. Observation: A 35-year-old man with stenosing and fistulizing ileocolic Crohn's disease developed squamous cell carcinoma mimicking a groin fold abscess. After surgical drainage of the abscess, despite antibiotics and therapy combining azathioprine with infliximab, the abscess has recurred. Biopsies revealed a cutaneous squamous cell carcinoma. Palliative radiotherapy-chemotherapy was initiated, but the patient died after 3 months. Conclusion: This observation illustrates the increased risk of non-melanoma skin cancers in inflammatory bowel disease patients, particularly those exposed to thiopurines, and the value of diagnosing them at an early stage.","PeriodicalId":12568,"journal":{"name":"Future Science OA","volume":"6 2","pages":""},"PeriodicalIF":2.5,"publicationDate":"2023-12-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139007838","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A randomized clinical trial: timing of indwelling urethral catheter removal following transurethral resection of prostate 一项随机临床试验:经尿道前列腺切除术后留置导尿管拔除的时机
Future Science OA Pub Date : 2023-11-10 DOI: 10.2144/fsoa-2023-0195
Saddam Al Demour, Mohammad T Al-Zubi, Mera Ababneh, Samer F Al-Rawashdah, Muayyad Ahmad
{"title":"A randomized clinical trial: timing of indwelling urethral catheter removal following transurethral resection of prostate","authors":"Saddam Al Demour, Mohammad T Al-Zubi, Mera Ababneh, Samer F Al-Rawashdah, Muayyad Ahmad","doi":"10.2144/fsoa-2023-0195","DOIUrl":"https://doi.org/10.2144/fsoa-2023-0195","url":null,"abstract":"Aim: We aimed to evaluate early versus delayed removal of the indwelling urethral catheter (IUC) following transurethral resection of prostate (TURP). Methods: In this clinical trial conducted between July 2016 and June 2020, 90 patients underwent TURP were randomized equally into: group A, early IUC removal (24 h), and group B, delayed IUC removal (72 h). Results: The mean length of hospital stay was longer among the patients in group B. There were no significant differences in recatheterization, secondary bleeding, or UTI between groups A and B. The mean VAS score and CRBD were higher in group B. Conclusion: Early IUC removal following TURP is safe approach with favorable clinical outcomes. Clinical Trial Registration: NCT04363970 ( clinicaltrials.gov )","PeriodicalId":12568,"journal":{"name":"Future Science OA","volume":" 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-11-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135141664","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Marital status impacts survival of stage I non-small-cell lung cancer: a propensity-score matching analysis 婚姻状况影响I期非小细胞肺癌的生存:倾向评分匹配分析
Future Science OA Pub Date : 2023-11-07 DOI: 10.2144/fsoa-2023-0103
Li-Hong Qiu, Jia-Qi Song, Feng Jiang, Yuan-Yuan Zhao, Yu'e Liu, Lei-Lei Wu, Guo-Wei Ma
{"title":"Marital status impacts survival of stage I non-small-cell lung cancer: a propensity-score matching analysis","authors":"Li-Hong Qiu, Jia-Qi Song, Feng Jiang, Yuan-Yuan Zhao, Yu'e Liu, Lei-Lei Wu, Guo-Wei Ma","doi":"10.2144/fsoa-2023-0103","DOIUrl":"https://doi.org/10.2144/fsoa-2023-0103","url":null,"abstract":"Aim: This population-based analysis aimed to explore the associations among marital status, prognosis and treatment of stage I non-small-cell lung cancer. Materials &amp; methods: The propensity score matching (PSM), logistic regression and Cox proportional hazards model were used in this study. Results: A total of 13,937 patients were included. After PSM, 10579 patients were co-insured. The married were more likely to receive surgical treatment compared with the unmarried patients (OR: 1.841, p < 0.001), and patients who underwent surgery also tended to have better survival (HR: 0.293, p < 0.001). Conclusion: Compared with unmarried patients, a married group with stage I NSCLC had timely treatment and more satisfactory survival. This study highlights the importance of prompt help and care for unmarried patients.","PeriodicalId":12568,"journal":{"name":"Future Science OA","volume":"302 4","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-11-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135475324","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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