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Panduratin A mitigates inflammation and oxidative stress in DSS-induced colitis mice model. Panduratin A能减轻DSS诱导的结肠炎小鼠模型的炎症和氧化应激反应。
IF 2.4
Future Science OA Pub Date : 2024-12-01 Epub Date: 2024-11-19 DOI: 10.1080/20565623.2024.2428129
Abdelrahim Alqudah, Esam Qnais, Omar Gammoh, Yousra Bseiso, Mohammed Wedyan, Muna Oqal
{"title":"Panduratin A mitigates inflammation and oxidative stress in DSS-induced colitis mice model.","authors":"Abdelrahim Alqudah, Esam Qnais, Omar Gammoh, Yousra Bseiso, Mohammed Wedyan, Muna Oqal","doi":"10.1080/20565623.2024.2428129","DOIUrl":"10.1080/20565623.2024.2428129","url":null,"abstract":"<p><strong>Aim: </strong>This study explored Panduratin A's protective effects against DSS-induced colitis in mice, focusing on reducing inflammation and oxidative stress in the colon.</p><p><strong>Methods: </strong>Mice were treated with dextran sodium sulfate (DSS) and Panduratin A (3, 6, 18 mg/kg), and changes in body weight, colon length, Disease Activity Index (DAI), histopathology, inflammation markers including tumor necrosis factor- α (TNF-α), Interleukin-1 β (IL-1β), Myeloperoxidase (MPO), and oxidative stress, Malondialdehyde (MDA) were evaluated.</p><p><strong>Results: </strong>Panduratin A significantly reversed DSS-induced symptoms, including body weight loss, colonic length shortening, and DAI increase, while reducing histopathological damage. It lowered inflammatory markers and oxidative stress, suppressed NF-κB activation, and enhanced Nrf2 and HO-1 expression.</p><p><strong>Conclusion: </strong>Panduratin A shows promise as a colitis treatment, warranting further research for broader clinical application.</p>","PeriodicalId":12568,"journal":{"name":"Future Science OA","volume":"10 1","pages":"2428129"},"PeriodicalIF":2.4,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11581177/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142667545","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Investigating outcomes of coronary artery bypass graft (CABG) surgery: a single-center retrospective study in Jordan. 冠状动脉旁路移植手术（CABG）疗效调查：约旦单中心回顾性研究。
IF 2.4
Future Science OA Pub Date : 2024-12-01 Epub Date: 2024-11-25 DOI: 10.1080/20565623.2024.2430902
Emad Hijazi
{"title":"Investigating outcomes of coronary artery bypass graft (CABG) surgery: a single-center retrospective study in Jordan.","authors":"Emad Hijazi","doi":"10.1080/20565623.2024.2430902","DOIUrl":"10.1080/20565623.2024.2430902","url":null,"abstract":"<p><strong>Background: </strong>Coronary artery bypass graft (CABG) surgery brings significant cardiac benefits but also risks post-operative complications, including cognitive impairments and infections.</p><p><strong>Materials & methods: </strong>We analyzed 108 patient records between 2011 and 2021 at the Princess Muna Al-Hussein Cardiac Center, Irbid, Jordan. The primary endpoint was the occurrence of postoperative events.</p><p><strong>Results: </strong>Few patients (8.3%) faced complications like stroke and infections, with age and ICU stay length as significant risk factors. Patients with complications often experienced left ventricular impairments and required inotropic support.</p><p><strong>Conclusion: </strong>The study highlights the need for understanding CABG surgery complications to improve outcomes, emphasizing preventive care and personalized follow-up.</p>","PeriodicalId":12568,"journal":{"name":"Future Science OA","volume":"10 1","pages":"2430902"},"PeriodicalIF":2.4,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11591588/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142709805","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Promising approach for targeting ROBO1 with CAR NK cells to combat ovarian cancer primary tumor cells and organoids. 利用 CAR NK 细胞靶向 ROBO1 对抗卵巢癌原发肿瘤细胞和器官组织的方法前景广阔。
IF 2.4
Future Science OA Pub Date : 2024-07-11 Epub Date: 2024-07-29 DOI: 10.2144/fsoa-2023-0135
Yan Zhu, Luanhong Wang, Biyu Jiang, Yini Wang, Qing Wu, Sihua Hong, Xiaojing Wang, Yuancheng Li, Tian Guan, Haoyu Zeng, Congzhu Li
{"title":"Promising approach for targeting ROBO1 with CAR NK cells to combat ovarian cancer primary tumor cells and organoids.","authors":"Yan Zhu, Luanhong Wang, Biyu Jiang, Yini Wang, Qing Wu, Sihua Hong, Xiaojing Wang, Yuancheng Li, Tian Guan, Haoyu Zeng, Congzhu Li","doi":"10.2144/fsoa-2023-0135","DOIUrl":"10.2144/fsoa-2023-0135","url":null,"abstract":"<p><p><b>Aim:</b> This study aimed to explore using peripheral blood mononuclear cell (PBMC)-derived chimeric antigen receptor (CAR) NK cells targeting ROBO1 as a personalized medicine approach for ovarian cancer. <b>Methods:</b> A two-step strategy generated ROBO1-targeted CAR NK cells from PBMCs of ovarian cancer patients. Efficacy was evaluated using xCELLigence RTCA, CCK-8 and Live/Dead fluorescence assays. <b>Results:</b> ROBO1-NK cells exhibited higher efficiency in eradicating primary ovarian cancer cells and lysing ovarian tumor organoids compared with primary NK cells without ROBO1-CAR modification. <b>Conclusion:</b> These findings highlight the potential of developing ROBO1-targeted CAR-NK cells from patients' PBMCs as a personalized treatment option for ovarian cancer.</p>","PeriodicalId":12568,"journal":{"name":"Future Science OA","volume":"10 1","pages":"2340186"},"PeriodicalIF":2.4,"publicationDate":"2024-07-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11290772/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141787786","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Analysis of attitudes and practices toward gastroesophageal reflux disease among the general population of Pakistan. 分析巴基斯坦普通民众对胃食管反流病的态度和做法。
IF 2.5
Future Science OA Pub Date : 2024-06-06 eCollection Date: 2024-01-01 DOI: 10.2144/fsoa-2023-0144
Humaira Jabbar, Tooba Noor, Muhammad A Obaid, Areej Shakil, Muhammad I Obaid, Syeda I Aaqil, Usama Aa Memon, Zoha Mohsin
{"title":"Analysis of attitudes and practices toward gastroesophageal reflux disease among the general population of Pakistan.","authors":"Humaira Jabbar, Tooba Noor, Muhammad A Obaid, Areej Shakil, Muhammad I Obaid, Syeda I Aaqil, Usama Aa Memon, Zoha Mohsin","doi":"10.2144/fsoa-2023-0144","DOIUrl":"10.2144/fsoa-2023-0144","url":null,"abstract":"<p><p><b>Aim:</b> Gastro-esophageal reflux disease (GERD) is a growing health concern. <b>Methods:</b> In this cross-sectional study, participants' knowledge, attitude and practice toward GERD were assessed using a questionnaire. <b>Results:</b> In our study of 411 participants, 92.5% knew about GERD. Correctly identified risk factors were smoking (62.3%), fatty food (84.2%), spicy food (91.2%) and meal timing (80.8%). Identified symptoms were burning sensation (92.2%) and regurgitation (81.0%). 43.6% of participants were unaware of GERD's complications. Only 46.2% would seek medical advice for feeling full after eating, but 85% would for severe symptoms. 88.7 and 86.8% of participants showed willingness to amend diet and lifestyle. <b>Conclusion:</b> General population has knowledge regarding GERD and its risk factors but poor attitude and practices toward the condition.</p>","PeriodicalId":12568,"journal":{"name":"Future Science OA","volume":"10 1","pages":"2359843"},"PeriodicalIF":2.5,"publicationDate":"2024-06-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11160512/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141295907","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Assessment of lifestyle changes in combating the COVID-19 pandemic among people of Karachi, Pakistan. 评估巴基斯坦卡拉奇人改变生活方式以应对 COVID-19 大流行的情况。
IF 2.5
Future Science OA Pub Date : 2024-05-24 eCollection Date: 2024-01-01 DOI: 10.2144/fsoa-2023-0227
Mubashir Zafar, Tafazzul Hyder Zaidi, Nadira Hyder Zaidi, Muhammad Waqas Nisar Ahmed, Mahjabeen Shah, Umm E Habiba, Marrium Sultan Dar, Noor Ul Ain, Fatima Shahid, Hiba Hamid Meer
{"title":"Assessment of lifestyle changes in combating the COVID-19 pandemic among people of Karachi, Pakistan.","authors":"Mubashir Zafar, Tafazzul Hyder Zaidi, Nadira Hyder Zaidi, Muhammad Waqas Nisar Ahmed, Mahjabeen Shah, Umm E Habiba, Marrium Sultan Dar, Noor Ul Ain, Fatima Shahid, Hiba Hamid Meer","doi":"10.2144/fsoa-2023-0227","DOIUrl":"10.2144/fsoa-2023-0227","url":null,"abstract":"<p><p><b>Aim:</b> COVID-19 arose as a pandemic that wreaked havoc all over the world. Study determines lifestyle changes adopted by people of Karachi in response to COVID-19 pandemic. <b>Methods:</b> This was the cross-sectional study and carried out at public sector hospital and 218 participants were selected through random sampling method. <b>Results:</b> Lifestyle changes a statistically significant difference in nutrition (p = 0.000), physical activity (p = 0.000), workout (p = 0.000), smoking (p = 0.000), sleep hours (p = 0.000), and supplements (p = 0.000) before and during lockdown. Face masks were utilized by 38% of individuals, gloves by 19%, and social isolation was observed by 26%. 11% of participants did not follow any protocols. <b>Conclusion:</b> Study found significant differences in lifestyle habits such as diet, sleep, smoking and physical activity.</p>","PeriodicalId":12568,"journal":{"name":"Future Science OA","volume":"10 1","pages":"2340266"},"PeriodicalIF":2.5,"publicationDate":"2024-05-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11152586/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141261543","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Air embolism complicating endoscopic retrograde cholangiopancreatography. 内镜逆行胰胆管造影术并发空气栓塞。
IF 2.5
Future Science OA Pub Date : 2024-05-24 eCollection Date: 2024-01-01 DOI: 10.2144/fsoa-2023-0174
Mouna Medhioub, Becem Trabelsi, Amal Khsiba, Mohamed Saied, Moufida Mahmoudi, Asma Ben Mohamed, Manel Yacoubi, Lamine Hamzaoui, Mechaal Ben Ali
{"title":"Air embolism complicating endoscopic retrograde cholangiopancreatography.","authors":"Mouna Medhioub, Becem Trabelsi, Amal Khsiba, Mohamed Saied, Moufida Mahmoudi, Asma Ben Mohamed, Manel Yacoubi, Lamine Hamzaoui, Mechaal Ben Ali","doi":"10.2144/fsoa-2023-0174","DOIUrl":"10.2144/fsoa-2023-0174","url":null,"abstract":"<p><p><b>Aim:</b> Venous air embolism is a rare but potentially life threatening complication of endoscopic retrograde cholangiopancreatography. Diagnosis is difficult because of the lack of specific signs or symptoms. <b>Case:</b> A 62-year-old man underwent endoscopic retrograde cholangiopancreatography for choledocholithiasis. A cardiovascular collapse occurred during the procedure. The echocardiography showed air within the right ventricle. Aspiration of air from the right ventricle was done and saved the patient's life. <b>Conclusion:</b> We highlight through this case that increased awareness is essential for prompt recognition of the air embolism to allow life-saving therapy.</p>","PeriodicalId":12568,"journal":{"name":"Future Science OA","volume":"10 1","pages":"FSO941"},"PeriodicalIF":2.5,"publicationDate":"2024-05-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11152584/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141261488","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Effect of long-term proton pump inhibitors on phosphocalcium metabolism and bone mineral density. 长期服用质子泵抑制剂对磷钙代谢和骨矿物质密度的影响
IF 2.5
Future Science OA Pub Date : 2024-05-24 eCollection Date: 2024-01-01 DOI: 10.2144/fsoa-2023-0198
Hend Smaoui, Lassaad Chtourou, Dana Jallouli, Samar Ben Jemaa, Iheb Karaa, Mouna Boudabbous, Manel Moalla, Hela Gdoura, Leila Mnif, Ali Amouri, Rim Akrout, Fatma Ayadi, Sofien Baklouti, Nabil Tahri
{"title":"Effect of long-term proton pump inhibitors on phosphocalcium metabolism and bone mineral density.","authors":"Hend Smaoui, Lassaad Chtourou, Dana Jallouli, Samar Ben Jemaa, Iheb Karaa, Mouna Boudabbous, Manel Moalla, Hela Gdoura, Leila Mnif, Ali Amouri, Rim Akrout, Fatma Ayadi, Sofien Baklouti, Nabil Tahri","doi":"10.2144/fsoa-2023-0198","DOIUrl":"10.2144/fsoa-2023-0198","url":null,"abstract":"<p><p><b>Aim:</b> Although Proton pump inhibitors (PPIs) are well-tolerated, their long-term use may be associated with decreased bone mass. <b>Methods:</b> This is a case-control study including patients treated with PPIs (>1 year) and control subjects who have not received PPIs treatment. <b>Results:</b> A total of 90 patients and 90 matched controls were included. PPIs use was associated with hypocalcemia and hypomagnesemia. Vitamin D3 deficiency and hyperparathyroidism were associated with PPIs use. Long-term PPIs use was significantly associated with decreased bone density. Risk factors of decreased bone mineral density (BMD) included age >50 years, menopause, lack of sun exposure, double PPIs dose, daily intake, post-meal intake and association with a mucoprotective agent. <b>Conclusion:</b> Our results highlight the risk of decreased BMD in patients on long-term PPIs treatment.</p>","PeriodicalId":12568,"journal":{"name":"Future Science OA","volume":"10 1","pages":"FSO977"},"PeriodicalIF":2.5,"publicationDate":"2024-05-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11152587/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141261524","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Protective potential of mesenchymal stem cells against COVID-19 during pregnancy. 间充质干细胞对孕期 COVID-19 的保护潜力。
IF 2.5
Future Science OA Pub Date : 2024-05-20 eCollection Date: 2024-01-01 DOI: 10.2144/fsoa-2023-0179
Sihem Aouabdi, Doaa Aboalola, Samer Zakari, Suliman Alwafi, Taoufik Nedjadi, Rawiah Alsiary
{"title":"Protective potential of mesenchymal stem cells against COVID-19 during pregnancy.","authors":"Sihem Aouabdi, Doaa Aboalola, Samer Zakari, Suliman Alwafi, Taoufik Nedjadi, Rawiah Alsiary","doi":"10.2144/fsoa-2023-0179","DOIUrl":"10.2144/fsoa-2023-0179","url":null,"abstract":"<p><p>SARS-CoV-2 causes COVID-19. COVID-19 has led to severe clinical illnesses and an unprecedented death toll. The virus induces immune inflammatory responses specifically cytokine storm in lungs. Several published reports indicated that pregnant females are less likely to develop severe symptoms compared with non-pregnant. Putative protective role of maternal blood circulating fetal mesenchymal stem cells (MSCs) has emerged and have been put forward as an explanation to alleviated symptoms. MSCs with immune-modulatory, anti-inflammatory and anti-viral roles, hold great potential for the treatment of COVID-19. MSCs could be an alternative to treat infections resulting from the SARS-CoV-2 and potential future outbreaks. This review focuses on the MSCs putative protective roles against COVID-19 in pregnant females.</p>","PeriodicalId":12568,"journal":{"name":"Future Science OA","volume":"10 1","pages":"FSO924"},"PeriodicalIF":2.5,"publicationDate":"2024-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11149780/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141247662","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Human umbilical cord mesenchymal stem cells combined with porcine small intestinal submucosa promote the healing of full-thickness skin injury in SD rats. 人脐带间充质干细胞与猪小肠粘膜下层结合可促进 SD 大鼠全厚皮肤损伤的愈合。
IF 2.5
Future Science OA Pub Date : 2024-05-20 eCollection Date: 2024-01-01 DOI: 10.2144/fsoa-2023-0123
Xu XiaoMing, Chen Yan, Gu JiaMing, Liang LiTao, Zhang LiJuan, Song Ying, Yuan Lu, Song Qian, Dong Jian
{"title":"Human umbilical cord mesenchymal stem cells combined with porcine small intestinal submucosa promote the healing of full-thickness skin injury in SD rats.","authors":"Xu XiaoMing, Chen Yan, Gu JiaMing, Liang LiTao, Zhang LiJuan, Song Ying, Yuan Lu, Song Qian, Dong Jian","doi":"10.2144/fsoa-2023-0123","DOIUrl":"10.2144/fsoa-2023-0123","url":null,"abstract":"<p><p><b>Aim:</b> To assess the therapeutic potential of human umbilical cord mesenchymal stem cells (hUCMSCs) combined with porcine small intestinal submucosa (SIS) on full-thickness skin injuries in rats. <b>Methods:</b> We established full-thickness skin injury models in Sprague-Dawley rats, dividing them into blank control, SIS, hUCMSCs and hUCMSCs combined with SIS. We monitored wound healing, scores and area, and analyzed inflammatory cells, microvessel density and collagen fibers after 12 days. <b>Results:</b> The blank group showed no healing, forming a scar of 0.6 × 0.5 cm<sup>2</sup>, while SIS and hUCMSCs groups exhibited incomplete healing with 0.4 × 0.5 cm<sup>2</sup> scabs. Wound healing was significantly better in the hUCMSCs combined with the SIS group. <b>Conclusion:</b> Local application of hUCMSCs combined with SIS enhances full-thickness skin injury wound healing in rats.</p>","PeriodicalId":12568,"journal":{"name":"Future Science OA","volume":"10 1","pages":"FSO955"},"PeriodicalIF":2.5,"publicationDate":"2024-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11137796/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141179426","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Erratum. 勘误。
IF 2.5
Future Science OA Pub Date : 2024-05-20 eCollection Date: 2024-01-01 DOI: 10.2144/fsoa.15.57e1
{"title":"Erratum.","authors":"","doi":"10.2144/fsoa.15.57e1","DOIUrl":"https://doi.org/10.2144/fsoa.15.57e1","url":null,"abstract":"<p><p>[This corrects the article DOI: 10.2144/fsoa.15.57.].</p>","PeriodicalId":12568,"journal":{"name":"Future Science OA","volume":"10 1","pages":"FSO"},"PeriodicalIF":2.5,"publicationDate":"2024-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11137783/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141179422","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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