Future Science OA最新文献_第6页

Advantages of Hao's esophagogastrostomy by fissure technique: study protocol for a prospective clinical trial. 郝氏食管胃吻合术的优势：前瞻性临床试验的研究方案。

IF 2.1

Future Science OA Pub Date : 2025-12-01 Epub Date: 2025-07-28 DOI: 10.1080/20565623.2025.2540746

Wen-Liang Cui, Ze-Qin Wang, Ming-Ye Ma, Ya-Ping Wang, Lu-Chun Hua, Jun Hong, Han-Kun Hao

{"title":"Advantages of Hao's esophagogastrostomy by fissure technique: study protocol for a prospective clinical trial.","authors":"Wen-Liang Cui, Ze-Qin Wang, Ming-Ye Ma, Ya-Ping Wang, Lu-Chun Hua, Jun Hong, Han-Kun Hao","doi":"10.1080/20565623.2025.2540746","DOIUrl":"10.1080/20565623.2025.2540746","url":null,"abstract":"Introduction: In the past, total gastrectomy (TG) was the most common surgical method, but now proximal gastrectomy (PG) has gradually become an alternative surgical method for proximal gastric and esophagogastric junction cancer. However, there is no recognized preferred anastomosis method after PG. In view of this, Hao's esophagogastrostomy by fissure technique (HEFT) proposed by the author's team can reduce the difficulty of the operation and the occurrence of postoperative complications. 13 cases that underwent this technique were free of complications during postoperative follow-up, and the intraoperative anastomosis time was significantly shorter than that reported in the literature for Double-flap technique (45 min vs. 79-114 min).Methods and analysis: This is a single-center, single-arm, prospective clinical study. We will recruit 30 eligible patients consecutively to undergo HEFT. The primary objective is to assess perioperative safety. The secondary objectives: (1) Incidence of postoperative reflux esophagitis and anastomotic stenosis; (2) Assess the quality of life at 3 Months Postoperatively by EORTC QLQ-C30 and EORTC QLQ-STO22 scales. Measurement data will be presented as mean ± standard deviation (<math><mrow><mrow><mover><mrow><mrow><mi>x</mi></mrow></mrow><mo>¯</mo></mover></mrow><mo> </mo><mo>±</mo><mtext> s</mtext></mrow></math>). Count data will be presented as rates (%).","PeriodicalId":12568,"journal":{"name":"Future Science OA","volume":"11 1","pages":"2540746"},"PeriodicalIF":2.1,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12309549/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144729628","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The perioperative implications of the patient with Obstructive Sleep Apnea (OSA) - a narrative review. 阻塞性睡眠呼吸暂停（OSA）患者围手术期的意义-一篇叙述性综述。

IF 2.1

Future Science OA Pub Date : 2025-12-01 Epub Date: 2025-08-01 DOI: 10.1080/20565623.2025.2540744

Erin Tracy, Cole Crandall, Ana Grajales, Anthony Plunkett

引用次数: 0

Recent advances in oral cryotherapy for the management of anticancer therapy-induced oral mucositis. 口腔冷冻治疗抗癌治疗引起的口腔黏膜炎的最新进展。

IF 2.4

Future Science OA Pub Date : 2025-12-01 Epub Date: 2025-07-03 DOI: 10.1080/20565623.2025.2527500

Feng Lin Hu, Ni Lou, Guo Lin Wu

{"title":"Recent advances in oral cryotherapy for the management of anticancer therapy-induced oral mucositis.","authors":"Feng Lin Hu, Ni Lou, Guo Lin Wu","doi":"10.1080/20565623.2025.2527500","DOIUrl":"10.1080/20565623.2025.2527500","url":null,"abstract":"Oral mucositis (OM) is a prevalent complication of cancer therapy, frequently associated with oral pain, dysphagia, malnutrition, and systemic infections. OM that develops during cancer treatment can result in delays or interruptions in anti-cancer therapies, significantly impacting patients' quality of life. Oral cryotherapy (OC) involves the use of crushed ice, specialized cryotherapy devices, and other cooling methods to lower the temperature in the oral cavity during chemotherapy or radiotherapy, thereby reducing the incidence and severity of cancer treatment-related OM. This review aims to elucidate the role of OC in managing OM induced by anticancer therapy by summarizing the mechanisms, specific operational procedures, and potential adverse reactions associated with cryotherapy for OM. It also compares the efficacy of cryotherapy with other preventive and therapeutic approaches for OM, as well as their combined applications. While cryotherapy demonstrates effectiveness in preventing the incidence and severity of cancer treatment-related OM, it is not effective for OM that has already been formed because of previous treatments. Therefore, integrating cryotherapy with basic oral care, photobiomodulation therapy, pharmacological interventions, traditional Chinese medicine, and other modalities is essential for optimal prevention and management of cancer treatment-related OM.","PeriodicalId":12568,"journal":{"name":"Future Science OA","volume":"11 1","pages":"2527500"},"PeriodicalIF":2.4,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12233692/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144553113","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Distinct somatic mutation profiles in colon cancer by behavioral comorbidity. 不同的体细胞突变谱在结肠癌的行为合并症。

IF 2.1

Future Science OA Pub Date : 2025-12-01 Epub Date: 2025-09-18 DOI: 10.1080/20565623.2025.2561501

Raphael E Cuomo

{"title":"Distinct somatic mutation profiles in colon cancer by behavioral comorbidity.","authors":"Raphael E Cuomo","doi":"10.1080/20565623.2025.2561501","DOIUrl":"10.1080/20565623.2025.2561501","url":null,"abstract":"Background: Tobacco use, obesity, and type 2 diabetes are risk factors for colorectal cancer, but whether they generate distinct tumor mutation patterns is unclear. Tobacco is a known mutagen, while obesity and diabetes may act through metabolic and inflammatory pathways.Methods: We analyzed colon cancer patients from the University of California Health Data Warehouse, linking clinical sequencing data to diagnosis-based indicators of tobacco dependence, obesity, and type 2 diabetes. For each gene-behavior pair, we conducted reverse logistic regressions and calculated a combined score reflecting the strength and specificity of association adjusting for demographic covariates and cancer stage. Multidimensional scaling and clustering assessed behavioral differentiation.Results: Of 981 gene-behavior tests, 87 pairs exhibited a behavioral association at p < 0.001 in adjusted models. Of these, 60 tobacco, 12 obesity, and 9 diabetes pairs had affinity ≥0.5; 48 tobacco pairs exceeded 1.0. Mean (SD) combined scores were 1.39 (0.79) for tobacco, 1.24 (0.88) for obesity, and 0.74 (0.39) for diabetes. Exemplars included KEAP1 and CDKN2A (tobacco), ASPSCR1 and PGR (obesity), and a smaller diabetes signal led by MAF.Conclusions: Tobacco dependence is associated with a more mutagenic and distinct somatic mutation profile in colon cancer, suggesting fundamental differences in behavioral mechanisms of carcinogenesis.","PeriodicalId":12568,"journal":{"name":"Future Science OA","volume":"11 1","pages":"2561501"},"PeriodicalIF":2.1,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12452446/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145080388","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Systematic review of scapular Ewing's sarcoma and a rare case of massive pleural effusion as primary manifestation. 肩胛骨尤文氏肉瘤1例以大量胸腔积液为主要表现。

IF 2.1

Future Science OA Pub Date : 2025-12-01 Epub Date: 2025-09-30 DOI: 10.1080/20565623.2025.2567163

Hela Cherif, Haifa Ben Romdhane, Sarra Ben Rejeb, Soumaya Debiche, Mehdi Charfi, Ferdaous Yangui, Imen Bouassida, Salma Mokaddem, Mohamed Ridha Charfi

{"title":"Systematic review of scapular Ewing's sarcoma and a rare case of massive pleural effusion as primary manifestation.","authors":"Hela Cherif, Haifa Ben Romdhane, Sarra Ben Rejeb, Soumaya Debiche, Mehdi Charfi, Ferdaous Yangui, Imen Bouassida, Salma Mokaddem, Mohamed Ridha Charfi","doi":"10.1080/20565623.2025.2567163","DOIUrl":"10.1080/20565623.2025.2567163","url":null,"abstract":"Background: Ewing Sarcoma (ES) ranks second among mesenchymal malignancies in children and young adults. Scapular Ewing sarcoma (SES) represents <4% of ES cases with limited literature. We report a case of SES with uncommon respiratory symptoms in a 37-year-old male and conduct a systematic review to improve comprehension of SES demographics, clinical attributes, and management.Literature review: A systematic search was conducted in PubMed, Scopus, and Google Scholar including SES case reports and series from 1983 to 2024. Using Covidence, references were screened. Two reviewers independently assessed eligibility, resulting in the inclusion of 32 studies. Risk of bias was assessed using Joanna Briggs Institute (JBI) checklists. A total of 124 SES cases were analyzed. SES predominantly affected adolescents with median age of 16 years; IQR: 12-24, and most commonly presented with shoulder swelling. A case within this cohort exhibited respiratory symptoms. Metastases occurred in 30% of cases, mainly to the lungs and bones. Remission was achieved in 64% of cases, while 29.7% had fatal outcomes.Conclusion: This review highlights the predominance of shoulder symptoms and identifies a unique respiratory presentation. Given the high metastatic rate, standardized protocols are needed to ensure oncological control and preserve shoulder function.Registration: PROSPERO,CRD420251008692.","PeriodicalId":12568,"journal":{"name":"Future Science OA","volume":"11 1","pages":"2567163"},"PeriodicalIF":2.1,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12490403/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145199000","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Colonic strictures in Crohn's disease: a non-surgical survival. 结肠狭窄在克罗恩病：非手术生存。

IF 2.4

Future Science OA Pub Date : 2025-12-01 Epub Date: 2025-01-25 DOI: 10.1080/20565623.2025.2455911

Sarra Laabidi, Hamed Aboubecrine, Salma Souissi, Donia Gouiaa, Asma Labidi, Nadia Ben Mustapha, Anis Haddad, Amine Sebai, Meriem Serghini, Monia Fekih, Hanene Jaziri, Jalel Boubaker

{"title":"Colonic strictures in Crohn's disease: a non-surgical survival.","authors":"Sarra Laabidi, Hamed Aboubecrine, Salma Souissi, Donia Gouiaa, Asma Labidi, Nadia Ben Mustapha, Anis Haddad, Amine Sebai, Meriem Serghini, Monia Fekih, Hanene Jaziri, Jalel Boubaker","doi":"10.1080/20565623.2025.2455911","DOIUrl":"10.1080/20565623.2025.2455911","url":null,"abstract":"Background: Colonic stenosis in Crohn's disease (CD) is uncommon, and data on surgery-free survival are limited. This study aimed to determine surgery-free survival rates and identify associated factors.Patients and methods: A retrospective study was conducted from 2003 to 2022, including patients with CD complicated by colonic stenosis. Patients with uncertain diagnoses or follow-up periods of less than six months were excluded.Results: Fifty-six patients were included (median age 44 years [range 14-65], male-to-female ratio = 0.93). Surgery-free survival rates were 58.9% at 6 months, 43.7% at 2 years, and 31.7% at 5 years, with an average surgery-free survival of 46.7 months. Univariate analysis showed that joint manifestations (p = 0.01), corticosteroids (p = 0.02), anti-TNF alpha (p = 0.02), salicylates (p = 0.02), and azathioprine (p = 0.01) increased surgery-free survival. Complications such as collections or internal fistulas (p = 0.03), parietal ulceration on imaging (p = 0.01), and acute intestinal obstruction (p = 0.01) were associated with reduced surgery-free survival. In multivariate analysis, biologic therapy was the only independent protective factor against surgery (p = 0.001, OR = 0.19).Conclusion: The early introduction of biologic therapy is crucial for increasing surgery-free survival in patients with colonic stenosis in CD, given the limited effectiveness of conventional treatments.","PeriodicalId":12568,"journal":{"name":"Future Science OA","volume":"11 1","pages":"2455911"},"PeriodicalIF":2.4,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11776860/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143037897","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A phytotherapeutic approach to hinder the resistance against clindamycin by MRSA: in vitro and in silico studies. 通过MRSA抑制克林霉素耐药性的植物治疗方法：体外和计算机研究。

IF 2.4

Future Science OA Pub Date : 2025-12-01 Epub Date: 2025-02-02 DOI: 10.1080/20565623.2025.2458438

Amal Mayyas, Ali Al-Samydai, Nehaya Al-Karablieh, Waleed A Zalloum, Deniz Al-Tawalbeh, Farah Al-Mamoori, Rula A Amr, Hamdi Al Nsairat, Simone Carradori, Lidia Kamal Al-Halaseh, Talal Aburjai

{"title":"A phytotherapeutic approach to hinder the resistance against clindamycin by MRSA: in vitro and in silico studies.","authors":"Amal Mayyas, Ali Al-Samydai, Nehaya Al-Karablieh, Waleed A Zalloum, Deniz Al-Tawalbeh, Farah Al-Mamoori, Rula A Amr, Hamdi Al Nsairat, Simone Carradori, Lidia Kamal Al-Halaseh, Talal Aburjai","doi":"10.1080/20565623.2025.2458438","DOIUrl":"10.1080/20565623.2025.2458438","url":null,"abstract":"Aims: This study investigates the potential effects of essential oils (EOs) in enhancing the efficacy of clindamycin against Methicillin-resistant Staphylococcus aureus (MRSA) using in vitro and computer simulations. The research seeks to identify essential oils that exhibit synergistic activity with clindamycin and determine their potential key active components.Materials and methods: Essential oils commonly used in traditional medicine were tested for their antimicrobial activity against MRSA. The minimum inhibitory concentration (MIC) was determined using in vitro microdilution assays. A synergistic test with clindamycin was performed, and molecular docking studies evaluated the interaction between a key compound (trans-cinnamaldehyde) and MRSA protein.Results: EOs from Cinnamomum verum, Rosmarinus officinalis, Salvia officinalis, and Thymus vulgaris demonstrated significant inhibitory and synergistic activities against MRSA, standard strain, and human clinical isolates. Gas Chromatography/Mass Spectroscopy identified trans-cinnamaldehyde, eucalyptol, and thymol as prominent antibacterial compounds. Molecular docking studies confirmed trans-cinnamaldehyde's strong binding to MRSA's AgrA protein, elucidating its enhanced efficacy.Conclusion: The study underscores the potential of plant-based therapies to augment the effectiveness of conventional antibiotics like clindamycin in combating MRSA and addressing antibiotic resistance by integrating traditional plant remedies with modern medical approaches.","PeriodicalId":12568,"journal":{"name":"Future Science OA","volume":"11 1","pages":"2458438"},"PeriodicalIF":2.4,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11792796/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143079369","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Prevalence and risk factors of H. pylori infection among outpatient in Karaganda city (Kazakhstan). 哈萨克斯坦卡拉干达市门诊患者幽门螺杆菌感染流行及危险因素分析

IF 2.4

Future Science OA Pub Date : 2025-12-01 Epub Date: 2025-02-10 DOI: 10.1080/20565623.2025.2461429

Aizhan Seisenbekova, Yelena Laryushina, Yekaterina Yukhnevich, Alyona Lavrinenko, Alexey Shkreba

引用次数: 0

User-friendliness of the pain assessment in impaired cognition (PAIC15) in persons with aphasia: a pilot study. 失语症患者认知障碍疼痛评估的用户友好性（PAIC15）：一项试点研究。

IF 2.4

Future Science OA Pub Date : 2025-12-01 Epub Date: 2025-01-27 DOI: 10.1080/20565623.2025.2456440

Neeltje J de Vries, Hanneke J A Smaling, Jenny T van der Steen, Wilco P Achterberg

引用次数: 0

Evaluating cytidine, uridine, and gabapentin combinations for pain modulation and p-CREB expression in neuropathic model. 评价胞苷、尿苷和加巴喷丁联合使用对神经性模型疼痛调节和p-CREB表达的影响。

IF 2.4

Future Science OA Pub Date : 2025-12-01 Epub Date: 2025-03-31 DOI: 10.1080/20565623.2025.2483137

Esam Y Qnais, Muna Barakat, Rabaa Y Athamneh, Mohammad A A Al-Najjar, Lujain F Alzaghari, Dinesh Kumar Chellappan, Abdelrahim Alqudah

{"title":"Evaluating cytidine, uridine, and gabapentin combinations for pain modulation and p-CREB expression in neuropathic model.","authors":"Esam Y Qnais, Muna Barakat, Rabaa Y Athamneh, Mohammad A A Al-Najjar, Lujain F Alzaghari, Dinesh Kumar Chellappan, Abdelrahim Alqudah","doi":"10.1080/20565623.2025.2483137","DOIUrl":"10.1080/20565623.2025.2483137","url":null,"abstract":"Aims: To evaluate the analgesic and neuroprotective effects of cytidine, uridine, and gabapentin-administered alone and in combination-in models of diabetic neuropathy and formalin-induced acute and inflammatory pain.Materials & methods: Oral doses of cytidine, uridine, and gabapentin (100 mg/kg each) were administered to rats with streptozotocin-induced diabetic neuropathy and in a formalin test model. Behavioral responses were recorded at 30, 60, and 120 minutes following treatment after five weeks of diabetes induction. Spinal cord p-CREB expression was measured to assess molecular changes, and pretreatments with naloxone, yohimbine, and methysergide were employed to explore opioid, adrenergic, and serotonergic contributions.Results: All treatments significantly reduced formalin-induced pain in both acute and inflammatory phases (p < 0.05; p < 0.001) and increased mechanical pain thresholds in the diabetic neuropathy model at all-time points (p < 0.05). Combination therapy proved more effective than gabapentin alone (p < 0.05) and was associated with decreased spinal p-CREB levels, indicating altered anti-nociceptive signaling.Conclusions: The combined use of cytidine, uridine, and gabapentin enhances analgesia and neuroprotection compared to monotherapy, supporting its potential as a novel, analgesic-free treatment strategy for diabetic neuropathy.","PeriodicalId":12568,"journal":{"name":"Future Science OA","volume":"11 1","pages":"2483137"},"PeriodicalIF":2.4,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11959892/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143752198","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0