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Overlap syndrome of seronegative primary biliary cholangitis and small duct primary sclerosing cholangitis: a first case report and literature review 血清阴性原发性胆汁性胆管炎和小导管原发性硬化性胆管炎重叠综合征：首例病例报告和文献综述
IF 2.5
Future Science OA Pub Date : 2024-01-01 DOI: 10.2144/fsoa-2023-0187
Salma Souissi, S. Laabidi, N. B. Mustpha, Ines Chelly, M. Serghini, M. Fékih, A. Laabidi, J. Boubaker
{"title":"Overlap syndrome of seronegative primary biliary cholangitis and small duct primary sclerosing cholangitis: a first case report and literature review","authors":"Salma Souissi, S. Laabidi, N. B. Mustpha, Ines Chelly, M. Serghini, M. Fékih, A. Laabidi, J. Boubaker","doi":"10.2144/fsoa-2023-0187","DOIUrl":"https://doi.org/10.2144/fsoa-2023-0187","url":null,"abstract":"Primary biliary cholangitis (PBC), primary sclerosing cholangitis (PSC), and autoimmune hepatitis (AIH) are distinct liver diseases. Cases combining PBC and PSC, are extremely rare. Here, we present a case of a 39-year-old woman with a history of colonic Crohn's disease treated with azathioprine. Discontinuation of the medication was prompted by abnormal liver function tests, but subsequent evaluations revealed persistent liver injury. Extensive diagnostic investigations, including imaging, serological tests, and liver biopsy, were conducted leading to a diagnosis of PBC-PSC overlap syndrome based on the presence of concentric lamellar fibrosis and chronic non-suppurative destructive cholangitis. The patient responded well to ursodeoxycholic acid treatment. This case emphasizes the importance of recognizing and diagnosing rare overlap syndromes, particularly those involving PBC and PSC, to ensure appropriate management and improve patient outcomes.","PeriodicalId":12568,"journal":{"name":"Future Science OA","volume":null,"pages":null},"PeriodicalIF":2.5,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140523870","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Cirrhotic cardiomyopathy: a subject that's always topical 肝硬化心肌病：永远的热门话题
IF 2.5
Future Science OA Pub Date : 2024-01-01 DOI: 10.2144/fsoa-2023-0110
Mona Boudabbous, R. Hammemi, H. Gdoura, L. Chtourou, M. Moalla, L. Mnif, A. Amouri, Leila Abid, N. Tahri
{"title":"Cirrhotic cardiomyopathy: a subject that's always topical","authors":"Mona Boudabbous, R. Hammemi, H. Gdoura, L. Chtourou, M. Moalla, L. Mnif, A. Amouri, Leila Abid, N. Tahri","doi":"10.2144/fsoa-2023-0110","DOIUrl":"https://doi.org/10.2144/fsoa-2023-0110","url":null,"abstract":"Cirrhosis is the final stage in the development of hepatic fibrosis in chronic liver disease. It is associated with major hemodynamic disturbances defining the hyperdynamic circulation and may be complicated by specific cardiac involvement or cirrhotic cardiomyopathy which is a silent clinical condition that typically remains asymptomatic until the late stages of liver disease. Recently, new criteria defining CC, based on modern concepts and knowledge of heart failure, have been proposed. Despite knowledge of the main mechanisms behind this entity, there is no specific treatment available for cirrhotic cardiomyopathy. The management approach for symptomatic cardiomyopathy in cirrhotic patients is similar to that for left ventricular failure in non-cirrhotic individuals.","PeriodicalId":12568,"journal":{"name":"Future Science OA","volume":null,"pages":null},"PeriodicalIF":2.5,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140516355","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Molecular mechanisms of Y chromosome loss and UTY gene activity Y 染色体缺失和UTY 基因活性的分子机制
IF 2.5
Future Science OA Pub Date : 2024-01-01 DOI: 10.2144/fsoa-2024-0031
Berjas Abumsimir, Talal S Al-Qaisi, Sima Zein
{"title":"Molecular mechanisms of Y chromosome loss and UTY gene activity","authors":"Berjas Abumsimir, Talal S Al-Qaisi, Sima Zein","doi":"10.2144/fsoa-2024-0031","DOIUrl":"https://doi.org/10.2144/fsoa-2024-0031","url":null,"abstract":"","PeriodicalId":12568,"journal":{"name":"Future Science OA","volume":null,"pages":null},"PeriodicalIF":2.5,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140525232","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Eradication of Helicobacter pylori: a prospective comparative randomized trial of standard versus optimized quadruple therapy 根除幽门螺杆菌：标准四联疗法与优化四联疗法的前瞻性比较随机试验
IF 2.5
Future Science OA Pub Date : 2024-01-01 DOI: 10.2144/fsoa-2023-0316
Salma Souissi, Cyrine Makni, Basma Chaieb, Amine Jarraya, Nadia Toulgui, L. Jmal, Mouna Mlika, Chadlia Fendri, Mohamed Bouchoucha, R. Razgallah, Leila Belhadj Ammar, O. Bousnina, Fawzi Mezni, Awatef Jmal, Lamia Kallel
{"title":"Eradication of Helicobacter pylori: a prospective comparative randomized trial of standard versus optimized quadruple therapy","authors":"Salma Souissi, Cyrine Makni, Basma Chaieb, Amine Jarraya, Nadia Toulgui, L. Jmal, Mouna Mlika, Chadlia Fendri, Mohamed Bouchoucha, R. Razgallah, Leila Belhadj Ammar, O. Bousnina, Fawzi Mezni, Awatef Jmal, Lamia Kallel","doi":"10.2144/fsoa-2023-0316","DOIUrl":"https://doi.org/10.2144/fsoa-2023-0316","url":null,"abstract":"The treatment of Helicobacter pylori infection remains a challenge. None of the proposed treatment regimens has resulted in a 100% eradication rate. The aim of our study was to compare the rate of H. pylori eradication after standard or dose-optimized amoxicillin quadruple therapy. We conducted a prospective comparative study collating patients naive to any anti- H. pylori treatment and with chronic H. pylori infection documented by histological examination. Patients were randomly assigned to either standard quadruple therapy or optimized quadruple therapy. Eradication control was performed by urea breath test. Eighty-eight eligible patients were included with 44 in each group.There was no significant difference between the eradication rates of Qo-14 and Qs-14 neither in ITT (84 vs 70.4%; p = 0.127) nor in PP (82.1 vs 77.7%; p = 0.473). Compliance and tolerance appeared similar in each group.","PeriodicalId":12568,"journal":{"name":"Future Science OA","volume":null,"pages":null},"PeriodicalIF":2.5,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140517696","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Different modalities to manage rheumatoid arthritis: an A to Z story 治疗类风湿性关节炎的不同方法：从A到Z的故事
IF 2.5
Future Science OA Pub Date : 2024-01-01 DOI: 10.2144/fsoa-2023-0134
M. Raslan, S. Raslan, E. Shehata, A. S. Mahmoud, N. Sabri, Khalid J. Alzahrani, F. Alzahrani, I. Halawani, V. Azevedo, Kenneth Lundstrom, D. Barh
{"title":"Different modalities to manage rheumatoid arthritis: an A to Z story","authors":"M. Raslan, S. Raslan, E. Shehata, A. S. Mahmoud, N. Sabri, Khalid J. Alzahrani, F. Alzahrani, I. Halawani, V. Azevedo, Kenneth Lundstrom, D. Barh","doi":"10.2144/fsoa-2023-0134","DOIUrl":"https://doi.org/10.2144/fsoa-2023-0134","url":null,"abstract":"Aim: To investigate different approaches to RA treatment that might lead to greater efficacy and better safety profiles. Methods: The Search strategy was based on medical subject headings, and screening and selection were based on inclusion/exclusion criteria. Results & discussion: Early therapy is critical for disease control and loss of bodily function. The most promising outcomes came from the development of disease-modifying anti-rheumatic drugs. Different foods have anti-inflammatory and antioxidant qualities that protect against the development of rheumatoid arthritis (RA). Some dietary patterns and supplements have been shown to have potential protective benefits against RA. Conclusion: Improvement in the quality of life of RA patients requires a tailored management approach based on the current patient medical data.","PeriodicalId":12568,"journal":{"name":"Future Science OA","volume":null,"pages":null},"PeriodicalIF":2.5,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140517240","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Pernicious anemia presenting with dysphagia and melanoderma: a confusing manifestation 恶性贫血伴有吞咽困难和黑皮病：一种令人困惑的表现
IF 2.5
Future Science OA Pub Date : 2024-01-01 DOI: 10.2144/fsoa-2023-0176
Salma Souissi, M. Ayari, Imen Abdellali, Rim Bourguiba, S. Belakhal, Taieb Jomni, Mohamed Hedi Doggui
{"title":"Pernicious anemia presenting with dysphagia and melanoderma: a confusing manifestation","authors":"Salma Souissi, M. Ayari, Imen Abdellali, Rim Bourguiba, S. Belakhal, Taieb Jomni, Mohamed Hedi Doggui","doi":"10.2144/fsoa-2023-0176","DOIUrl":"https://doi.org/10.2144/fsoa-2023-0176","url":null,"abstract":"Vitamin B12 deficiency is widely recognized as a common cause of anemia. However, symptoms such as dysphagia, melanoderma, and pancytopenia, although less frequent, can also be associated with this deficiency. We report the case of a 47-year-old Caucasian man presented with dysphagia to solids associated to high heart rate, dyspnea and melanoderma. He was diagnosed with severe anemia (hemoglobin 4 g/dl) in association with pancytopenia. Further investigation confirmed that the underlying cause was severe vitamin B12 deficiency secondary to pernicious anemia. Subsequent treatment with vitamin B12 supplements led to a significant improvement in all symptoms. A review of the existing literature corroborated the rarity of severe anemia occurring in conjunction with dysphagia and melanoderma due to B12 deficiency.","PeriodicalId":12568,"journal":{"name":"Future Science OA","volume":null,"pages":null},"PeriodicalIF":2.5,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140521110","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Enhancing chemosensitivity of PANC1 pancreatic cancer cells to gemcitabine using ANGTPL4, Notch1 and NF-κβ1 siRNAs 利用 ANGTPL4、Notch1 和 NF-κβ1 siRNA 增强 PANC1 胰腺癌细胞对吉西他滨的化疗敏感性
IF 2.5
Future Science OA Pub Date : 2024-01-01 DOI: 10.2144/fsoa-2023-0145
Abdulfattah Al-Kadash, W. Alshaer, Ismail Sami Mahmoud, Suha Wehaibi, Malek A. Zihlif
{"title":"Enhancing chemosensitivity of PANC1 pancreatic cancer cells to gemcitabine using ANGTPL4, Notch1 and NF-κβ1 siRNAs","authors":"Abdulfattah Al-Kadash, W. Alshaer, Ismail Sami Mahmoud, Suha Wehaibi, Malek A. Zihlif","doi":"10.2144/fsoa-2023-0145","DOIUrl":"https://doi.org/10.2144/fsoa-2023-0145","url":null,"abstract":"Aim: siRNA can silence targeted genes with lesser toxicity than therapeutic drugs. Therefore, this study aims to investigate new approaches to treat pancreatic cancer (PC) using combinations of siRNA and gemcitabine. Methods: Three genes, ANGTPL4, Notch1 and NF-κβ1, were silenced using siRNA, and their anti-proliferative effects were studied in combination with gemcitabine on pancreatic cancer cell line (PANC-1) using MTT viability assay. Results: Our results showed a significant reduction in PANC-1 cells growth upon treating cells with gemcitabine and single and combinations of siRNA sequences specific for ANGTPL4, Notch1 and NF-κβ1 genes. Conclusion: Co-transfection of gemcitabine-treated PANC-1 cells with ANGPTL4, Notch1 and NF-κβsiRNAs enhances the chemosensitivity of PANC-1 cells to gemcitabine can be a promising therapeutic approach.","PeriodicalId":12568,"journal":{"name":"Future Science OA","volume":null,"pages":null},"PeriodicalIF":2.5,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140525155","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Intestinal T-cell lymphoma not otherwise specified: a case report and literature review 非特异性肠 T 细胞淋巴瘤：病例报告和文献综述
IF 2.5
Future Science OA Pub Date : 2024-01-01 DOI: 10.2144/fsoa-2023-0119
Sarra Laabidi, Rabeb Hamouga, Sirine Bouslama, Rym Sellami, Soumoud Shimi, A. Labidi, Jalel Boubaker
{"title":"Intestinal T-cell lymphoma not otherwise specified: a case report and literature review","authors":"Sarra Laabidi, Rabeb Hamouga, Sirine Bouslama, Rym Sellami, Soumoud Shimi, A. Labidi, Jalel Boubaker","doi":"10.2144/fsoa-2023-0119","DOIUrl":"https://doi.org/10.2144/fsoa-2023-0119","url":null,"abstract":"Intestinal T-cell lymphoma, not otherwise specified (ITCL, NOS), primarily affects the small bowel but can involve the stomach and large bowel. This report presents an uncommon case of ITCL, NOS in a patient affecting the large bowel, supported by a literature review. An 87-year-old female presented with abdominal pain, fever, vomiting and weight loss. Imaging revealed nodular thickening of the transverse and right colon, confirmed as polypoid mass lesions with ulceration through colonoscopy and biopsy, indicating ITCL, NOS. CT scan showed adrenal nodes classifying it as stage VI. The patient was referred for palliative care and passed away 40 days later, likely due to tumor progression. This case underscores the rarity of large bowel ITCL, NOS and the diagnosis challenge.","PeriodicalId":12568,"journal":{"name":"Future Science OA","volume":null,"pages":null},"PeriodicalIF":2.5,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140519533","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Metastatic adult Wilms' tumor managed by chemotherapy, immunotherapy and target therapy: a case report 化疗、免疫疗法和靶向疗法治疗转移性成人威尔姆斯肿瘤：病例报告
IF 2.5
Future Science OA Pub Date : 2024-01-01 DOI: 10.2144/fsoa-2023-0156
Qian Zhao, Qi Xiong, Qi Song
{"title":"Metastatic adult Wilms' tumor managed by chemotherapy, immunotherapy and target therapy: a case report","authors":"Qian Zhao, Qi Xiong, Qi Song","doi":"10.2144/fsoa-2023-0156","DOIUrl":"https://doi.org/10.2144/fsoa-2023-0156","url":null,"abstract":"Wilms' tumor is a rare type of tumor in adult. Herein, we reported a case of 37-year-old female with adult Wilms' tumor (AWT) admitted in our institution. After a multidisciplinary team discussion, she underwent receiving immunotherapy plus chemotherapy and VEGF-targeted therapy. The tumor got smaller obviously after eight cycles of treatment. Our present case suggested that immunotherapy and anti-angiogenesis combined with chemotherapy is promising new approach for treating AWT. Moreover, we review the literatures reporting AWT with the purpose to improve the understanding of AWT treatment.","PeriodicalId":12568,"journal":{"name":"Future Science OA","volume":null,"pages":null},"PeriodicalIF":2.5,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140516120","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Acute and sub-chronic toxicity study of novel polyherbal formulation in non-alcoholic fatty liver using Wistar rats 利用 Wistar 大鼠进行的新型多草药配方对非酒精性脂肪肝的急性和亚慢性毒性研究
IF 2.5
Future Science OA Pub Date : 2024-01-01 DOI: 10.2144/fsoa-2023-0118
Anuragh Singh, K. Ilango
{"title":"Acute and sub-chronic toxicity study of novel polyherbal formulation in non-alcoholic fatty liver using Wistar rats","authors":"Anuragh Singh, K. Ilango","doi":"10.2144/fsoa-2023-0118","DOIUrl":"https://doi.org/10.2144/fsoa-2023-0118","url":null,"abstract":"Aim: This study assessed the acute and sub-chronic toxicity of a novel polyherbal formulation tablet in Wistar rats Materials & methods: Acute toxicity and sub-chronic toxicity was assessed following OECD (Organisation for the Economic Co-operation and Development) guidelines based on 423 and 408. Results & conclusion: No mortality and toxicity showed in rats during acute toxicity. The LD50 of the extract was at 2000 mg/kg. In sub-chronic study, both sex rats were orally administered at 250, 500,1000 and 2000 mg/kg for 90 days and revealed no significant difference (p < 0.05) in hematological and other parameters compared with the control. Histopathology study did not reveal morphological alteration. The No observed adverse effect level of the tablet was observed until 2000 mg/kg.","PeriodicalId":12568,"journal":{"name":"Future Science OA","volume":null,"pages":null},"PeriodicalIF":2.5,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140524630","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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