Future Science OA最新文献_第7页

Serum HE4 and polymorphisms in MMP9 and MMP13 associated with survival outcome in patients with endometrial carcinoma: a retrospective cohort study and nomogram development. 血清HE4和MMP9和MMP13多态性与子宫内膜癌患者生存结局相关：一项回顾性队列研究和nomogram发展

IF 2.5

Future Science OA Pub Date : 2026-12-01 Epub Date: 2026-04-25 DOI: 10.1080/20565623.2026.2658215

Renliang Li, Suying Zhou, Hai Wang, Longyi Wang, Jiaohong Wu, Lixiao Sha, Min Guo, Jiayong Zheng

{"title":"Serum HE4 and polymorphisms in MMP9 and MMP13 associated with survival outcome in patients with endometrial carcinoma: a retrospective cohort study and nomogram development.","authors":"Renliang Li, Suying Zhou, Hai Wang, Longyi Wang, Jiaohong Wu, Lixiao Sha, Min Guo, Jiayong Zheng","doi":"10.1080/20565623.2026.2658215","DOIUrl":"10.1080/20565623.2026.2658215","url":null,"abstract":"Aims: Endometrial cancer (EC) is the most common gynecologic malignancy. Identifying prognostic biomarkers can improve outcome prediction and risk stratification.Patients and methods: This study evaluated the prognostic value of serum human epididymis protein 4 (HE4) levels and matrix metalloproteinase (MMP)9/MMP13 gene polymorphisms in EC. A total of 232 surgical EC patients (Jan 2021-Oct 2022) were analyzed. Progression-free survival (PFS) and overall survival (OS) were assessed.Results: Significant differences in disease stage, tumor grade, and MMP9 R279Q and MMP13 rs2252070 phenotypes were found between patients with and without disease progression. Similarly, serum levels of carcinoembryonic antigen (CEA), carbohydrate antigen 125 (CA125), and HE4 also differed significantly between these groups. Significant differences were found between surviving patients and deceased patients in terms of stage (p < 0.001), grade (p < 0.001), HE4 level (p < 0.001), and CEA level (p = 0.001). The area under the receiver operating characteristic curve (AUC) for the three-year PFS prediction model was 0.935 (95% confidence interval [CI]: 0.891-0.978), and that for the OS model was 0.914 (95% CI: 0.845-0.983).Conclusions: HE4 is a valuable biomarker associated with three-year survival in EC. The phenotypes of MMP9 R279Q and MMP13 rs2252070 may also be associated with three-year PFS.","PeriodicalId":12568,"journal":{"name":"Future Science OA","volume":"12 1","pages":"2658215"},"PeriodicalIF":2.5,"publicationDate":"2026-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13114125/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147768885","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Factors associated with drug-resistant epilepsy in adults from Southern Kazakhstan. 哈萨克斯坦南部成人耐药癫痫相关因素

IF 2.5

Future Science OA Pub Date : 2026-12-01 Epub Date: 2026-04-30 DOI: 10.1080/20565623.2026.2665757

Gulzira Baimakhanova, Nursultan Nurdinov, Gulnaz Nuskabayeva, Nazira Zharkinbekova, Karlygash Sadykova, Akbota Skenderova, Mehmet Ziya Gencer, Islamkhan Doszhanov, Nigara Yerkhojayeva, Assel Anarbayeva, Shakhista Skenderova, Dana Kaldarkhan

{"title":"Factors associated with drug-resistant epilepsy in adults from Southern Kazakhstan.","authors":"Gulzira Baimakhanova, Nursultan Nurdinov, Gulnaz Nuskabayeva, Nazira Zharkinbekova, Karlygash Sadykova, Akbota Skenderova, Mehmet Ziya Gencer, Islamkhan Doszhanov, Nigara Yerkhojayeva, Assel Anarbayeva, Shakhista Skenderova, Dana Kaldarkhan","doi":"10.1080/20565623.2026.2665757","DOIUrl":"10.1080/20565623.2026.2665757","url":null,"abstract":"Introduction: The prevalence of drug-resistant epilepsy (DRE) among epilepsy patients has not decreased despite better diagnostic methods and treatment options because it affects approximately one-third of all epilepsy patients. The research aims to identify which clinical patterns and social characteristics contribute to drug resistance.Methods: This retrospective analytical cross-sectional study included 300 patients with epilepsy in Southern Kazakhstan. The participants received their drug resistance status through ILAE criteria, which classified them into drug-sensitive (DSE) or drug-resistant groups. Patient data was studied through clinical and socio-demographic evaluations, EEG and MRI assessments, and MoCA cognitive performance tests.Results: The research discovered drug-resistant epilepsy in 37% of participants. The DRE patients were 35 ± 12 years old at the time of study, while DSE patients were 39 ± 15 years old (p = 0.023). The development of DRE became more likely when patients experienced their first seizure at a young age and when they had multiple seizures throughout the day (p < 0.01). The presence of MRI abnormalities increased the risk of drug resistance by 2.42 times (95% CI: 1.3-4.23) when compared to drug-sensitive epilepsy patients (p = 0.002).Conclusion: The study revealed that early seizure onset, prolonged duration, severe seizures, brain imaging abnormalities, and lower cognitive performance are related to DRE.","PeriodicalId":12568,"journal":{"name":"Future Science OA","volume":"12 1","pages":"2665757"},"PeriodicalIF":2.5,"publicationDate":"2026-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13134400/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147768874","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Parental knowledge, socioeconomic factors and barriers to HPV vaccination uptake among children in Lebanon: a cross-sec. 黎巴嫩儿童接种HPV疫苗的父母知识、社会经济因素和障碍：交叉分析

IF 2.1

Future Science OA Pub Date : 2026-12-01 Epub Date: 2026-01-28 DOI: 10.1080/20565623.2026.2620985

Maroun Matar, Andrew Farhat, Fatima Hussein, Pascal Salameh, Sarah El Yaman, Malak Shreim

{"title":"Parental knowledge, socioeconomic factors and barriers to HPV vaccination uptake among children in Lebanon: a cross-sec.","authors":"Maroun Matar, Andrew Farhat, Fatima Hussein, Pascal Salameh, Sarah El Yaman, Malak Shreim","doi":"10.1080/20565623.2026.2620985","DOIUrl":"https://doi.org/10.1080/20565623.2026.2620985","url":null,"abstract":"Background: Human papillomavirus (HPV) is among the causes of cervical and other cancers globally, but vaccination rates are low in Lebanon. Parental decisions may be influenced by cultural sensitivities, misinformation, and financial constraints.Objective: This study evaluates the prevalence of HPV vaccination among children in Lebanon and identifies demographic, socioeconomic, and informational determinants of parental choice.Methods: A survey was conducted at two hospital-based universities in Beirut between August 2022 and March 2024 as part of a cross-sectional study. A structured questionnaire was given to Lebanese parents of children aged 9-18 to assess HPV knowledge, vaccine awareness, and barriers. Data were examined in SPSS, with bivariate and multivariate analyses to reveal predictors of vaccine uptake.Results: Among 100 participating parents, 23% reported vaccinating their children. Females were more likely to be vaccinated than males (p = 0.04). Awareness that HPV causes cancer and affects both genders was significantly associated with uptake (p = 0.049). High cost was a major barrier (p = 0.002), while doctors were the most trusted source of information.Conclusion: HPV vaccination rates among Lebanese children remain low due to financial barriers and limited awareness. Targeted education and integration into national immunization programs are essential.","PeriodicalId":12568,"journal":{"name":"Future Science OA","volume":"12 1","pages":"2620985"},"PeriodicalIF":2.1,"publicationDate":"2026-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12867392/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146118590","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The potential of human milk oligosaccharides in ameliorating traumatic brain injury-induced cognitive impairment in mice. 人乳寡糖改善小鼠外伤性脑损伤引起的认知障碍的潜力。

IF 2.1

Future Science OA Pub Date : 2026-12-01 Epub Date: 2026-02-01 DOI: 10.1080/20565623.2026.2622241

Dongliang He, Renli He, Wei Duan, Guilan Li, Qin Kang

{"title":"The potential of human milk oligosaccharides in ameliorating traumatic brain injury-induced cognitive impairment in mice.","authors":"Dongliang He, Renli He, Wei Duan, Guilan Li, Qin Kang","doi":"10.1080/20565623.2026.2622241","DOIUrl":"10.1080/20565623.2026.2622241","url":null,"abstract":"Objective: To investigate the ameliorative effect and underlying mechanisms of human milk oligosaccharides (HMOs) on cognitive impairment induced by traumatic brain injury (TBI) in mice.Materials and methods: Forty-eight C57BL/6 mice were randomly divided into the sham-operated group, TBI group, and TBI+HMOs group. The TBI model was established via controlled cortical impact (CCI). Mice in the TBI+HMOs group received daily HMOs administration by gavage, while other groups were given normal saline. Relevant indicators were detected using behavioral tests, pathological staining, Western blot, and other methods.Results: HMOs significantly improved cognitive function in TBI mice, inhibited hippocampal oxidative stress and the expression of proinflammatory cytokines (IL-1β, IL-6, TNF-α), alleviated intestinal barrier injury, and regulated the expression of synaptophysin, BDNF, and pro-BDNF.Conclusion: HMOs exert neuroprotective effects by targeting central inflammation, oxidative stress, synaptic function, and intestinal barrier integrity, providing a novel natural therapeutic candidate for TBI treatment.","PeriodicalId":12568,"journal":{"name":"Future Science OA","volume":"12 1","pages":"2622241"},"PeriodicalIF":2.1,"publicationDate":"2026-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12867443/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146100137","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cultural practices and knee osteoarthritis in Central Asia: a case-control study on risk and protective factors. 中亚地区的文化习俗与膝骨关节炎：一项关于风险和保护因素的病例对照研究。

IF 2.1

Future Science OA Pub Date : 2026-12-01 Epub Date: 2025-12-17 DOI: 10.1080/20565623.2025.2602339

Almasbek Akhmetov, Yerden Khaumet, Ikilas Moldaliyev, Azamat Seksenbayev, Ainash Oshibayeva, Saltanat Kyrykbayeva, Gulnaz Nuskabayeva, Akylbek Ibragim

{"title":"Cultural practices and knee osteoarthritis in Central Asia: a case-control study on risk and protective factors.","authors":"Almasbek Akhmetov, Yerden Khaumet, Ikilas Moldaliyev, Azamat Seksenbayev, Ainash Oshibayeva, Saltanat Kyrykbayeva, Gulnaz Nuskabayeva, Akylbek Ibragim","doi":"10.1080/20565623.2025.2602339","DOIUrl":"10.1080/20565623.2025.2602339","url":null,"abstract":"Introduction: Knee osteoarthritis (KOA) is a degenerative joint disease that leads to pain, stiffness, and disability. While established risk factors such as age, obesity, and joint injury are well-documented, the role of cultural practices remains underexplored. This study investigates the association between traditional cultural practices and KOA prevalence in Central Asia.Methods: A case-control study was conducted between January and March 2025 in Turkestan, Kazakhstan, involving 337 KOA cases and 685 matched controls. Participants completed structured questionnaires assessing demographic characteristics, lifestyle habits, and cultural practices. Unconditional logistic regression analyses identified associations between cultural factors and KOA, adjusting for age, sex, BMI, education level, physical workload, and type of residence.Results: Frequent floor sitting (OR = 4.25, 95% CI: 3.02-5.99), squat toilet use (OR = 2.32, 95% CI: 1.66-3.23), and rural residence (OR = 7.57, 95% CI: 4.99-11.48) were strongly associated with KOA. Daily prayer postures did not significantly differ between cases and controls.Conclusions: Traditional cultural practices involving prolonged knee flexion were associated with KOA. Public health initiatives should consider culturally appropriate strategies that may help mitigate knee strain. Further longitudinal research is needed to establish causality.","PeriodicalId":12568,"journal":{"name":"Future Science OA","volume":"12 1","pages":"2602339"},"PeriodicalIF":2.1,"publicationDate":"2026-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12716035/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145767872","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cancer and dementia incidence are strongly correlated worldwide: evidence from cross-national regression analyses. 癌症和痴呆发病率在世界范围内密切相关：来自跨国回归分析的证据。

IF 2.1

Future Science OA Pub Date : 2026-12-01 Epub Date: 2025-12-22 DOI: 10.1080/20565623.2025.2602336

Wenpeng You, Brendon J Coventry, Maciej Henneberg

{"title":"Cancer and dementia incidence are strongly correlated worldwide: evidence from cross-national regression analyses.","authors":"Wenpeng You, Brendon J Coventry, Maciej Henneberg","doi":"10.1080/20565623.2025.2602336","DOIUrl":"10.1080/20565623.2025.2602336","url":null,"abstract":"Background: Cancer and dementia are two major global health challenges influenced by population aging and socioeconomic transitions. Both impose substantial burdens, yet their relationship at the population level is insufficiently explored. This study investigated the global association between cancer incidence and dementia incidence, while accounting for developmental, demographic, and healthcare-related factors.Methods: Data were obtained from the Institute for Health Metrics and Evaluation. Covariates included economic affluence, urbanization, reduced selection opportunity, and life expectancy e(60). Analyses across 204 countries employed correlations, partial correlations, principal component analysis, and multiple linear regression (enter and stepwise). Subgroup analyses were stratified by income level, development status, WHO regions, and geopolitical groupings.Results: Cancer incidence was strongly correlated with dementia incidence worldwide (r = 0.873; ρ = 0.938, p < 0.001). Associations remained consistent across regions, particularly in upper-middle-income and developing countries. Partial correlations showed the relationship persisted after adjustment, with cancer explaining 59.8% of dementia variance. Regression models revealed that socioeconomic and demographic factors explained 51.7% of the variance, rising to 80.1% with cancer included.Conclusion: Cancer incidence is a dominant independent predictor of dementia incidence globally, surpassing traditional factors. Findings highlight shared determinants and emphasize the importance of integrated chronic disease strategies, especially in low-resource settings.","PeriodicalId":12568,"journal":{"name":"Future Science OA","volume":"12 1","pages":"2602336"},"PeriodicalIF":2.1,"publicationDate":"2026-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12724431/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145804047","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Comparative analysis of JCI and nationally accredited medical organizations with day surgical hospital. JCI与国家认可的日间外科医院的比较分析。

IF 2.1

Future Science OA Pub Date : 2026-12-01 Epub Date: 2025-12-11 DOI: 10.1080/20565623.2025.2598252

Kaisar Kudabayev, Aigul Ismailova, Kenesh Dzhusupov, Roza Suleimenova, Aiman Mussina, Gulnar Mustafinova, Bakhyt Yeleussizova, Nurlan Smagulov

{"title":"Comparative analysis of JCI and nationally accredited medical organizations with day surgical hospital.","authors":"Kaisar Kudabayev, Aigul Ismailova, Kenesh Dzhusupov, Roza Suleimenova, Aiman Mussina, Gulnar Mustafinova, Bakhyt Yeleussizova, Nurlan Smagulov","doi":"10.1080/20565623.2025.2598252","DOIUrl":"10.1080/20565623.2025.2598252","url":null,"abstract":"Aims: This study aimed to assess healthcare professionals' attitudes toward accreditation and compare perceptions between staff working in Joint Commission International (JCI)-accredited and nationally accredited medical institutions in Astana, Kazakhstan.Methods: A cross-sectional survey conducted among health professionals at a JCI-accredited hospital and two nationally accredited city polyclinics. The questionnaire comprised 38 items assessing employee satisfaction, teamwork cohesion, and perceived service quality.Results: A total of 191 healthcare workers participated in the study with a response rate of more than 95%. Overall, 54.4% of respondents reported positive attitudes toward JCI accreditation, and 4.1% expressed very positive views. Perceptions of JCI's impact on patient safety were more favorable, with 63.3% rating it positively. Respondents with more than five years of work experience expressed satisfaction that JCI accreditation enhanced patient safety. In addition, participants with postgraduate education (β = 0.25, 95% CI: 0.53-0.65; p < .001) and younger than 34 years (β = 0.555, 95% CI: 0.35-0.76; p < .001) were likely to recommend JCI accreditation.Conclusion: Healthcare professionals perceive JCI accreditation as a positive driver of patient safety, teamwork, and institutional quality culture. Implementing JCI measures may improve patient outcomes, strengthen staff engagement, and facilitate alignment with international standards.","PeriodicalId":12568,"journal":{"name":"Future Science OA","volume":"12 1","pages":"2598252"},"PeriodicalIF":2.1,"publicationDate":"2026-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12710945/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145742032","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Coexistence of IBD and subclinical chronic strongyloidiasis, in response to Trabelsi et al. IBD和亚临床慢性圆线虫病的共存，对Trabelsi等人的反应。

IF 2.1

Future Science OA Pub Date : 2026-12-01 Epub Date: 2026-04-07 DOI: 10.1080/20565623.2026.2656705

Akira Hokama

引用次数: 0

Exposure to environmental toxicants and obstructive sleep apnea: a cross-sectional study. 暴露于环境毒物和阻塞性睡眠呼吸暂停：一项横断面研究。

IF 2.5

Future Science OA Pub Date : 2026-12-01 Epub Date: 2026-06-08 DOI: 10.1080/20565623.2026.2682474

Weixing Liu, Pei Li, Zhiyuan Wang, Yue Liu, Jia Chen, Hui Liu, Qintai Yang, Jin Ye

{"title":"Exposure to environmental toxicants and obstructive sleep apnea: a cross-sectional study.","authors":"Weixing Liu, Pei Li, Zhiyuan Wang, Yue Liu, Jia Chen, Hui Liu, Qintai Yang, Jin Ye","doi":"10.1080/20565623.2026.2682474","DOIUrl":"10.1080/20565623.2026.2682474","url":null,"abstract":"Objective: To evaluate associations between environmental toxicant (ET) exposures and obstructive sleep apnea (OSA) using an exposome-wide approach.Methods: This cross-sectional analysis included 13,161 participants from two NHANES cycles (2015-2016 and 2017-March 2020). Fifty-six toxicants across six classes (arsenic species, ethylene oxide, heavy metals, nicotine metabolites, VOC metabolites, and thyroid-disrupting compounds) were measured. OSA status was defined using a validated questionnaire based on self-reported symptoms. Exposome-wide association analysis (ExWAS) adjusted for sociodemographic, lifestyle, and clinical covariates, and restricted cubic spline (RCS) analysis characterized nonlinear exposure-response relationships.Results: The overall prevalence of OSA was 49% (n = 6,443). Nine ETs showed significant associations with OSA, including blood and urinary cadmium, seven volatile organic compound metabolites (e.g., 2,5-dimethylfuran, ethylbenzene, furan, o-xylene), and three urinary cysteine-derived metabolites (N-acetylcysteine derivatives). Subgroup analyses revealed higher susceptibility among women and individuals aged <65 years. RCS analyses demonstrated nonlinear, nonmonotonic relationships for cadmium and cysteine-derived metabolites with OSA prevalence.Conclusions: Nine ETs were significantly associated with OSA prevalence, with evidence of differential susceptibility by sex and age. These findings highlight environmental factors associated with OSA, which may serve as potential targets for future mechanistic research and public health interventions.","PeriodicalId":12568,"journal":{"name":"Future Science OA","volume":"12 1","pages":"2682474"},"PeriodicalIF":2.5,"publicationDate":"2026-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13251519/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148198448","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Nomograms for the prognosis prediction model of early-stage triple-negative breast cancer - based on SEER database. 基于SEER数据库的早期三阴性乳腺癌预后预测模型的nomogram。

IF 2.5

Future Science OA Pub Date : 2026-12-01 Epub Date: 2026-04-11 DOI: 10.1080/20565623.2026.2653059

Yaxue Wang, Fengyan Li

{"title":"Nomograms for the prognosis prediction model of early-stage triple-negative breast cancer - based on SEER database.","authors":"Yaxue Wang, Fengyan Li","doi":"10.1080/20565623.2026.2653059","DOIUrl":"10.1080/20565623.2026.2653059","url":null,"abstract":"Aims: Triple-negative breast cancer (TNBC) is aggressive and unresponsive to hormone therapy, drawing widespread attention to its treatment and prognosis. This study aimed to summarize the prognosis of early-stage TNBC and construct nomograms to accurately predict survival and improve treatment strategies.Patients & methods: The modeling group comprised early-stage TNBC patients from the SEER database. Prognostic factors were identified via Cox regression, and nomograms were developed using R software. A validating group with identical screening criteria was assembled from Sun Yat-sen University Cancer Center. Validation involved the Concordance index, Receiver Operating Characteristic curves, and calibration curves.Results: The modeling group included 14,389 patients and the validating group 1,146. Age and seven other factors were independent predictors (P < 0.05) and were incorporated into the nomograms. The C-indices for disease-free survival were 0.884 (95% CI: 0.876-0.892) in the modeling group and 0.686 (95% CI: 0.653-0.719) in the validating group. For overall survival, C-indices were 0.873 (95% CI: 0.863-0.883) and 0.741 (95% CI: 0.702-0.780), respectively.Conclusions: The constructed nomograms demonstrated good predictive performance and may serve as practical tools for risk stratification in early-stage TNBC. However, given the observational nature of the data, the associations between treatment-related factors and survival should be interpreted with caution and warrant confirmation in prospective studies.","PeriodicalId":12568,"journal":{"name":"Future Science OA","volume":"12 1","pages":"2653059"},"PeriodicalIF":2.5,"publicationDate":"2026-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13078201/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147662384","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0