Future Science OA最新文献_第7页

Rate of Helicobacter pylori acquisition in children and evidence of mother-child transmission in a Sub-Saharan setting. 撒哈拉以南地区儿童幽门螺杆菌感染率及母婴传播证据

IF 2.4

Future Science OA Pub Date : 2025-12-01 Epub Date: 2025-04-19 DOI: 10.1080/20565623.2025.2482497

Laure Brigitte Kouitcheu Mabeku, Kevin Neville Pohoko Foguieng, Jeannette Euranie Kouam Mewa, Paul Olivier Koki Ndombo

{"title":"Rate of Helicobacter pylori acquisition in children and evidence of mother-child transmission in a Sub-Saharan setting.","authors":"Laure Brigitte Kouitcheu Mabeku, Kevin Neville Pohoko Foguieng, Jeannette Euranie Kouam Mewa, Paul Olivier Koki Ndombo","doi":"10.1080/20565623.2025.2482497","DOIUrl":"https://doi.org/10.1080/20565623.2025.2482497","url":null,"abstract":"Background: This study aims to assess age at which Helicobacter pylori infection is acquired and the role of maternal infection status in the transmission of this infection to children.Research design and methods: This was a cross-sectional study conducted at the reference Pediatric Center in Cameroon for 8-months. A total of 204 children from birth to 5 years old and their mothers were enrolled. They were tested for the presence of H. pylori stool antigen. Information on sociodemographic and living conditions of children were collected using a structured questionnaire.Results: H. pylori stool antigen positivity was 26.0 and 57.4% among children and their mothers respectively. Infection begins two weeks after birth and peaks at 36 to 60 months old (51.6%). The crude odd ratio for H. pylori infection in children whose mothers were infected was 7.0921(2.5510-19.6078; p = 0.0001). Mothers low-income level [2.8901(1.0319-8.0645), p = 0.043] and preschool attendance [6.7567(1.5337-30.3030), p = 0.012] were significantly correlated to H. pylori positivity in children.Conclusions: Our finding showed that infected mothers and preschool attendance have a key role in intra-familial and extra-familial transmission of H. pylori infection among children in our milieu, that worse living conditions are the main risk factor for the contamination.","PeriodicalId":12568,"journal":{"name":"Future Science OA","volume":"11 1","pages":"2482497"},"PeriodicalIF":2.4,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12013415/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143961270","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The role of peripheral blood microRNAs in the pathogenesis and treatment response of age-related macular degeneration. 外周血microrna在老年性黄斑变性发病机制和治疗反应中的作用。

IF 2.4

Future Science OA Pub Date : 2025-12-01 Epub Date: 2025-04-04 DOI: 10.1080/20565623.2025.2482499

Meng Kong, Jingwen Li, Nianting Tong

引用次数: 0

Atypical acquired hemophilia linked with primary biliary cholangitis: a unique case presentation. 非典型获得性血友病与原发性胆道胆管炎：一个独特的病例介绍。

IF 2.4

Future Science OA Pub Date : 2025-12-01 Epub Date: 2025-04-07 DOI: 10.1080/20565623.2025.2489329

Fatma Megdiche, Nour Siala, Faten Kallel, Imen Krichen, Hend Hachicha, Imen Frikha, Maha Charfi, Naourez Kallel, Moez Medhaffar, Hatem Masmoudi, Moez Elloumi, Choumous Kallel

引用次数: 0

Pharmacogenetics of anti-seizure medications in Arab countries: a comprehensive review. 阿拉伯国家抗癫痫药物的药理学研究综述。

IF 2.4

Future Science OA Pub Date : 2025-12-01 Epub Date: 2025-07-16 DOI: 10.1080/20565623.2025.2528490

Rania Magadmi

{"title":"Pharmacogenetics of anti-seizure medications in Arab countries: a comprehensive review.","authors":"Rania Magadmi","doi":"10.1080/20565623.2025.2528490","DOIUrl":"10.1080/20565623.2025.2528490","url":null,"abstract":"Epilepsy, a prevalent neurological disorder, is characterized by recurring seizures due to atypical neural activity, impacting millions globally. Epileptic seizures are the sudden, involuntary jerking or trembling movements caused by abnormal neural activity and may lead to damage in the brain or other parts of the body. Although epilepsy is usually manageable with anti-seizure medications (ASMs), a considerable subset of patients experiences drug resistance or suboptimal treatment responses, highlighting the need for a more elaborate approach to therapy. Studies show that genetic factors significantly influence not only the susceptibility to epilepsy but also the variability in individual responses to ASMs. This signifies the importance of personalized medicine in optimizing treatment guidelines based on genetic profiles. This review examines the pharmacogenetic factors influencing the efficacy and safety of anti-ASMs in Arab populations. In populations across Saudi Arabia, Jordan, Egypt, Tunisia, and Iraq, genetic testing for variants in genes like MTHFR, MDR1, ABCB1, miR-146a, GABARG2, IL-1β, EPHX1, and CYP3A422 can predict drug resistance, and response, improve drug dosing, and minimize ADRs. Clinicians can personalize therapy by employing specific genetic markers associated with drug metabolism and efficacy, leading to better treatment outcomes and reduced risk of drug-induced complications.","PeriodicalId":12568,"journal":{"name":"Future Science OA","volume":"11 1","pages":"2528490"},"PeriodicalIF":2.4,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12269706/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144642285","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Editorial for "a predictive model for irAEs in ESCC patients treated with PD-1 inhibitors based on blood indicators". 《基于血液指标的PD-1抑制剂治疗ESCC患者的irae预测模型》的社论。

IF 2.4

Future Science OA Pub Date : 2025-12-01 Epub Date: 2025-07-01 DOI: 10.1080/20565623.2025.2527486

Yaser Soleimani, Seyedehhoda Khatibmasjedi, Seyed Alireza Javadinia, Sara Shenavaei Zare, Reza Chaman

引用次数: 0

PAR2 regulates proliferation, migration of lung cancer and chemotherapy sensitivity by involving PTEN pathway. PAR2通过参与PTEN通路调控肺癌的增殖、迁移和化疗敏感性。

IF 2.1

Future Science OA Pub Date : 2025-12-01 Epub Date: 2025-07-21 DOI: 10.1080/20565623.2025.2535221

Mei Zhai, Hua Xue, Feng Li

{"title":"PAR2 regulates proliferation, migration of lung cancer and chemotherapy sensitivity by involving PTEN pathway.","authors":"Mei Zhai, Hua Xue, Feng Li","doi":"10.1080/20565623.2025.2535221","DOIUrl":"10.1080/20565623.2025.2535221","url":null,"abstract":"Background: Protease-activated receptor 2 (PAR2) is associated with tumor growth and metastasis. Here we examined the functions of PAR2 on growth, migration, invasion and chemosensitivity using both lung cancer cells and human lung cancer tissue.Methods: The effect of PAR2 on growth of lung cancer cells was examined by MTT assay. The function of PAR2 on migration and invasion of lung cancer cells was evaluated by transwell migration and matrigel invasion assays. The role of PAR2 on paclitaxel-induced apoptosis was evaluated by Caspase-Glo3/7 assay. PAR2 levels in human lung cancer tissue were measured by qRT-PCR assay.Results: Overexpression of PAR2 increased the proliferation, promoted migration and invasion in lung cancer cells. Up-regulation of PAR2 decreased the paclitaxel treatment sensitivity in lung cancer cells. PAR2 decreased paclitaxel-induced apoptosis by regulation of BAX and Bcl-2 expression. Aberrant expression of PTEN and p-AKT in lung cancer cells was impacted by PAR2. Serum PAR2 levels were increased in lung cancer patients. PAR2 expression was higher in human lung cancer tissue than normal lung tissues and associated with cancer stage.Conclusions: PAR2 displayed essential roles in lung carcinogenesis and might act as a potential biomarker to predict chemotherapy response and prognosis in lung cancer.","PeriodicalId":12568,"journal":{"name":"Future Science OA","volume":"11 1","pages":"2535221"},"PeriodicalIF":2.1,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12296048/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144674500","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Correlation between clinical features, medical history, and lifestyle factors with colorectal cancer stage. 临床特征、病史及生活方式因素与结直肠癌分期的关系

IF 2.1

Future Science OA Pub Date : 2025-12-01 Epub Date: 2025-08-06 DOI: 10.1080/20565623.2025.2543143

Asma Sghaier, Mohamed Amine Elghali, Nouha Haddad, Wassim Dziri, Amal Letaief, Imtinen Belaid, Sabri Youssef

{"title":"Correlation between clinical features, medical history, and lifestyle factors with colorectal cancer stage.","authors":"Asma Sghaier, Mohamed Amine Elghali, Nouha Haddad, Wassim Dziri, Amal Letaief, Imtinen Belaid, Sabri Youssef","doi":"10.1080/20565623.2025.2543143","DOIUrl":"10.1080/20565623.2025.2543143","url":null,"abstract":"Background: Colorectal cancer (CRC) represents a significant public health burden, with patient prognosis largely determined by the stage at diagnosis. Various factors, including modifiable lifestyle habits, may influence the disease stage at presentation.Aims: This study aimed to identify factors correlated with advanced tumor-node-metastasis (TNM) stages of CRC at diagnosis.Methods: We conducted a retrospective cross-sectional study over five years in the general surgery department of Farhat Hached Hospital, Sousse, Tunisia. The study included patients who underwent surgery for adenocarcinoma-like CRC.Results: Our study included 169 patients, with an average age of 62.57 years and a male predominance. Smoking was reported in 51% of cases, and alcohol consumption in 45.9%. Stage II was the most prevalent stage in our cohort (34.9%). Smoking (p < 0.001), alcohol consumption (p = 0.005), obesity (p = 0.026), anemia (p = 0.038), and the presence of an abdominal mass (p = 0.001) were significantly associated with advanced stages of CRC. While not statistically significant, male gender also appeared to be associated with advanced forms of CRC (p = 0.059).Conclusions: Our findings suggest that alcohol and tobacco consumption are associated with later diagnosis or may accelerate disease progression. This observed correlation with advanced stages suggests potential mechanisms without claiming direct causation. Implementing public health measures to reduce alcohol and tobacco consumption could decrease the likelihood of being diagnosed with advanced CRC.","PeriodicalId":12568,"journal":{"name":"Future Science OA","volume":"11 1","pages":"2543143"},"PeriodicalIF":2.1,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12330267/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144788793","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Downregulation of serum Foxc2 in dilated cardiomyopathy: association with disease severity and cardiac function. 扩张型心肌病患者血清Foxc2下调：与疾病严重程度和心功能的关系

IF 2.1

Future Science OA Pub Date : 2025-12-01 Epub Date: 2025-08-29 DOI: 10.1080/20565623.2025.2552085

Yufu Cai, Qionghui Huang, Shaobin Zhi, Guixian Guo, Mingfeng Huang, Xiaoyan Tang

{"title":"Downregulation of serum Foxc2 in dilated cardiomyopathy: association with disease severity and cardiac function.","authors":"Yufu Cai, Qionghui Huang, Shaobin Zhi, Guixian Guo, Mingfeng Huang, Xiaoyan Tang","doi":"10.1080/20565623.2025.2552085","DOIUrl":"10.1080/20565623.2025.2552085","url":null,"abstract":"Background: Dilated cardiomyopathy (DCM) is one of the most frequent non-ischemic causes of heart failure. Foxc2 has been implicated in cardiovascular disease and angiogenesis, but its role in DCM remains undefined. This study aimed to compare serum Foxc2 levels in DCM and non-DCM patients and to assess its clinical relevance.Methods: In this retrospective study, 92 patients (53 DCM, 39 non-DCM) were enrolled. Based on echocardiographic and clinical evaluations, patients were classified into non-DCM group (n = 39) and DCM group (n = 53). Serum Foxc2 concentrations were measured via ELISA, and correlations were analyzed with echocardiographic parameters and biomarkers (BNP, cTnI). ROC analysis assessed Foxc2's diagnostic performance, and Kaplan-Meier analysis evaluated 2-year MACE risk.Results: Serum Foxc2 levels were significantly lower in the DCM group (35.33 ± 27.99 μg/mL vs. 77.51 ± 28.94 μg/mL), and correlated with cardiac function (positive: LVEF, LVFS; negative: LVEDd, BNP, cTnI). ROC analysis demonstrated high diagnostic accuracy for Foxc2 (AUC 0.862). Patients with Foxc2 levels≥ 33.945 μg/mL showed a reduction in 2-year MACE risk (HR 0.187) compared to those with levels below the threshold.Conclusion: Foxc2 may serve as a promising biomarker for DCM diagnosis and prognosis, supporting for further mechanistic investigations.","PeriodicalId":12568,"journal":{"name":"Future Science OA","volume":"11 1","pages":"2552085"},"PeriodicalIF":2.1,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12407816/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144950388","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

ChatGPT's role in the rapidly evolving hematologic cancer landscape. ChatGPT在快速发展的血液学癌症领域中的作用。

IF 2.1

Future Science OA Pub Date : 2025-12-01 Epub Date: 2025-09-03 DOI: 10.1080/20565623.2025.2546259

Tiffany Nong, Sean Britton, Viralkumar Bhanderi, Justin Taylor

{"title":"ChatGPT's role in the rapidly evolving hematologic cancer landscape.","authors":"Tiffany Nong, Sean Britton, Viralkumar Bhanderi, Justin Taylor","doi":"10.1080/20565623.2025.2546259","DOIUrl":"10.1080/20565623.2025.2546259","url":null,"abstract":"Aims: Many patients seek accurate, understandable information about their disease and treatment, turning to the internet or messaging providers. This study aims to validate chatbots' ability to deliver accurate information, contributing to the literature on AI's role in cancer care and helping to improve these tools for patients and caregivers. Methods: A set of questions about hematologic malignancies was created with input from oncologists and reputable websites and then submitted to ChatGPT 3.5. Each response was rated by hematology-oncology physicians from strongly disagree (1) to strongly agree (5) regarding its accuracy and usefulness for patients, with multiple reviewers ensuring consistency. Results: The general queries category received a higher average score of 3.38 compared to 3.06 in the novel therapies category, indicating relatively better satisfaction. However, no question achieved scores greater than 4 (agree) or 5 (strongly agree), with most scores ranging from 3.0 to 3.8, reflecting a neutral stance, suggesting room for improvement. Conclusions: ChatGPT struggled with providing current and specific information for patient-specific queries and novel therapies, especially in rapidly advancing fields like acute myeloid leukemia. These deficiencies are likely due to AI's reliance on large data sets, leading to less influence from novel therapies.","PeriodicalId":12568,"journal":{"name":"Future Science OA","volume":"11 1","pages":"2546259"},"PeriodicalIF":2.1,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12413060/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144950404","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

LINC00313 functions as an oncogenic propellant and immunosuppressive marker in lung adenocarcinoma. LINC00313是肺腺癌的促癌剂和免疫抑制标志物。

IF 2.1

Future Science OA Pub Date : 2025-12-01 Epub Date: 2025-08-21 DOI: 10.1080/20565623.2025.2547557

Wen Wang, Yanhui Cui, Jianfu Heng, Jingjing Li, Guoli Li

{"title":"LINC00313 functions as an oncogenic propellant and immunosuppressive marker in lung adenocarcinoma.","authors":"Wen Wang, Yanhui Cui, Jianfu Heng, Jingjing Li, Guoli Li","doi":"10.1080/20565623.2025.2547557","DOIUrl":"10.1080/20565623.2025.2547557","url":null,"abstract":"Background: Despite advances in treatments, the prognosis for lung adenocarcinoma (LUAD) remains poor, underscoring the urgent need to identify novel therapeutic strategies. This study was conducted to investigate the potential role of LINC00313 as a biomarker and therapeutic target for LUAD.Methods: Databases GEPIA2 and GEO were used to analyze LINC00313 expression and prognosis. Analyses of pathways associated with LINC00313, and its relationships with immune infiltration, checkpoint therapy response and drug response were conducted using different bioinformatics tools. siRNA transfection, qRT-PCR, transwell and colony formation assays were performed on LUAD cells (A549).Results: LINC00313 is significantly upregulated in LUAD, and its expression is associated with high-grade cancer, poor prognosis and metastasis. In vitro studies showed that silencing LINC00313 reduced LUAD cell migration, invasion, and colony formation. Bioinformatics analyses indicated that LINC00313 expression was negatively associated with immune cell infiltration and the efficacy of immune checkpoint inhibitor therapy. Sensitivity analysis of chemotherapeutic drugs found that high expression of LINC00313 attenuated the effect of chemotherapeutic drugs like cisplatin, dabrafenib and lapatinib on LUAD.Conclusions: In conclusion, LINC00313 holds potential as a valuable biomarker and therapeutic target for the treatment of LUAD. However, further research is warranted to fully elucidate its clinical applications.","PeriodicalId":12568,"journal":{"name":"Future Science OA","volume":"11 1","pages":"2547557"},"PeriodicalIF":2.1,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12372514/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144950440","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0