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Protective potential of mesenchymal stem cells against COVID-19 during pregnancy. 间充质干细胞对孕期 COVID-19 的保护潜力。
IF 2.5
Future Science OA Pub Date : 2024-05-20 eCollection Date: 2024-01-01 DOI: 10.2144/fsoa-2023-0179
Sihem Aouabdi, Doaa Aboalola, Samer Zakari, Suliman Alwafi, Taoufik Nedjadi, Rawiah Alsiary
{"title":"Protective potential of mesenchymal stem cells against COVID-19 during pregnancy.","authors":"Sihem Aouabdi, Doaa Aboalola, Samer Zakari, Suliman Alwafi, Taoufik Nedjadi, Rawiah Alsiary","doi":"10.2144/fsoa-2023-0179","DOIUrl":"10.2144/fsoa-2023-0179","url":null,"abstract":"<p><p>SARS-CoV-2 causes COVID-19. COVID-19 has led to severe clinical illnesses and an unprecedented death toll. The virus induces immune inflammatory responses specifically cytokine storm in lungs. Several published reports indicated that pregnant females are less likely to develop severe symptoms compared with non-pregnant. Putative protective role of maternal blood circulating fetal mesenchymal stem cells (MSCs) has emerged and have been put forward as an explanation to alleviated symptoms. MSCs with immune-modulatory, anti-inflammatory and anti-viral roles, hold great potential for the treatment of COVID-19. MSCs could be an alternative to treat infections resulting from the SARS-CoV-2 and potential future outbreaks. This review focuses on the MSCs putative protective roles against COVID-19 in pregnant females.</p>","PeriodicalId":12568,"journal":{"name":"Future Science OA","volume":"10 1","pages":"FSO924"},"PeriodicalIF":2.5,"publicationDate":"2024-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11149780/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141247662","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Human umbilical cord mesenchymal stem cells combined with porcine small intestinal submucosa promote the healing of full-thickness skin injury in SD rats. 人脐带间充质干细胞与猪小肠粘膜下层结合可促进 SD 大鼠全厚皮肤损伤的愈合。
IF 2.5
Future Science OA Pub Date : 2024-05-20 eCollection Date: 2024-01-01 DOI: 10.2144/fsoa-2023-0123
Xu XiaoMing, Chen Yan, Gu JiaMing, Liang LiTao, Zhang LiJuan, Song Ying, Yuan Lu, Song Qian, Dong Jian
{"title":"Human umbilical cord mesenchymal stem cells combined with porcine small intestinal submucosa promote the healing of full-thickness skin injury in SD rats.","authors":"Xu XiaoMing, Chen Yan, Gu JiaMing, Liang LiTao, Zhang LiJuan, Song Ying, Yuan Lu, Song Qian, Dong Jian","doi":"10.2144/fsoa-2023-0123","DOIUrl":"10.2144/fsoa-2023-0123","url":null,"abstract":"<p><p><b>Aim:</b> To assess the therapeutic potential of human umbilical cord mesenchymal stem cells (hUCMSCs) combined with porcine small intestinal submucosa (SIS) on full-thickness skin injuries in rats. <b>Methods:</b> We established full-thickness skin injury models in Sprague-Dawley rats, dividing them into blank control, SIS, hUCMSCs and hUCMSCs combined with SIS. We monitored wound healing, scores and area, and analyzed inflammatory cells, microvessel density and collagen fibers after 12 days. <b>Results:</b> The blank group showed no healing, forming a scar of 0.6 × 0.5 cm<sup>2</sup>, while SIS and hUCMSCs groups exhibited incomplete healing with 0.4 × 0.5 cm<sup>2</sup> scabs. Wound healing was significantly better in the hUCMSCs combined with the SIS group. <b>Conclusion:</b> Local application of hUCMSCs combined with SIS enhances full-thickness skin injury wound healing in rats.</p>","PeriodicalId":12568,"journal":{"name":"Future Science OA","volume":"10 1","pages":"FSO955"},"PeriodicalIF":2.5,"publicationDate":"2024-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11137796/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141179426","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Erratum. 勘误。
IF 2.5
Future Science OA Pub Date : 2024-05-20 eCollection Date: 2024-01-01 DOI: 10.2144/fsoa.15.57e1
{"title":"Erratum.","authors":"","doi":"10.2144/fsoa.15.57e1","DOIUrl":"https://doi.org/10.2144/fsoa.15.57e1","url":null,"abstract":"<p><p>[This corrects the article DOI: 10.2144/fsoa.15.57.].</p>","PeriodicalId":12568,"journal":{"name":"Future Science OA","volume":"10 1","pages":"FSO"},"PeriodicalIF":2.5,"publicationDate":"2024-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11137783/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141179422","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Corrigendum. 更正。
IF 2.5
Future Science OA Pub Date : 2024-05-16 eCollection Date: 2024-01-01 DOI: 10.2144/fsoa-2020-0107c
{"title":"Corrigendum.","authors":"","doi":"10.2144/fsoa-2020-0107c","DOIUrl":"https://doi.org/10.2144/fsoa-2020-0107c","url":null,"abstract":"<p><p>[This corrects the article DOI: 10.2144/fsoa-2020-0107.].</p>","PeriodicalId":12568,"journal":{"name":"Future Science OA","volume":"10 1","pages":"FSO"},"PeriodicalIF":2.5,"publicationDate":"2024-05-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11149778/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141247649","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Corrigendum. 更正。
IF 2.5
Future Science OA Pub Date : 2024-05-16 eCollection Date: 2024-01-01 DOI: 10.2144/fsoa-2019-0157c
{"title":"Corrigendum.","authors":"","doi":"10.2144/fsoa-2019-0157c","DOIUrl":"https://doi.org/10.2144/fsoa-2019-0157c","url":null,"abstract":"<p><p>[This corrects the article DOI: 10.2144/fsoa-2019-0157.].</p>","PeriodicalId":12568,"journal":{"name":"Future Science OA","volume":"10 1","pages":"FSO"},"PeriodicalIF":2.5,"publicationDate":"2024-05-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11149779/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141247728","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Arthritis alleviation: unveiling the potential in Abrus precatorius macerated oil. 缓解关节炎：揭示 Abrus precatorius浸渍油的潜力。
IF 2.4
Future Science OA Pub Date : 2024-05-15 eCollection Date: 2024-01-01 DOI: 10.2144/fsoa-2023-0248
Sukanya Vijayan, Thirumal Margesan
{"title":"Arthritis alleviation: unveiling the potential in <i>Abrus precatorius</i> macerated oil.","authors":"Sukanya Vijayan, Thirumal Margesan","doi":"10.2144/fsoa-2023-0248","DOIUrl":"10.2144/fsoa-2023-0248","url":null,"abstract":"<p><p><b>Aim:</b> This study endeavors to explore the anti-arthritic effects of macerated oil derived from the plant's aerial parts. <b>Methods:</b> The macerated oil was prepared using maceration in coconut oil, and its phytochemical composition was elucidated using GC-MS. To assess its anti-arthritic activity, <i>in-vitro</i> studies were conducted using various assays. <b>Results & conclusion:</b> The macerated oil showed better antioxidant and anti-arthritic potential by <i>in</i>-<i>vitro</i> investigations. Molecular docking studies elucidated potential binding interactions between specific constituents of the oil and critical molecular targets implicated in the pathogenesis of arthritis, further substantiating its therapeutic potential. The results demonstrated that <i>Abrus precatorius</i> macerated oil could ameliorate arthritis severity in a dose-dependent manner.</p>","PeriodicalId":12568,"journal":{"name":"Future Science OA","volume":"10 1","pages":"FSO981"},"PeriodicalIF":2.4,"publicationDate":"2024-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11137774/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141179420","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Levels of anti-insulin antibodies in diabetic retinopathy patients: an observational cross-sectional study. 糖尿病视网膜病变患者的抗胰岛素抗体水平：一项观察性横断面研究。
IF 2.5
Future Science OA Pub Date : 2024-05-15 eCollection Date: 2024-01-01 DOI: 10.2144/fsoa-2024-0002
Bismark N Mohammed, Emmanuel K Ofori, Christian N Adekena, Seth K Amponsah, Henry Asare-Anane, Seth D Amanquah, Mubarak Abdul-Rahman, Kwesi N Amissah-Arthur
{"title":"Levels of anti-insulin antibodies in diabetic retinopathy patients: an observational cross-sectional study.","authors":"Bismark N Mohammed, Emmanuel K Ofori, Christian N Adekena, Seth K Amponsah, Henry Asare-Anane, Seth D Amanquah, Mubarak Abdul-Rahman, Kwesi N Amissah-Arthur","doi":"10.2144/fsoa-2024-0002","DOIUrl":"10.2144/fsoa-2024-0002","url":null,"abstract":"<p><p><b>Aim:</b> This study evaluated the levels of anti-insulin antibodies (AIAs) and the influence of some antidiabetic medications on AIA in diabetes mellitus (DM) patients with retinopathy. <b>Patient & methods:</b> An observational cross-sectional study. <b>Results:</b> A lower titer of AIA IgG was observed in the diabetic retinopathy (DR) and DM-only study categories compared with the control group [DR = 86 (5-560), DM-only = 50 (5-500), versus control = 200 (7-565); p = 0.017]. Taking nifedipine and metformin were negatively correlated (r = -0.32, p = 0.04) with the levels of AIA IgE in the DR group. <b>Conclusion:</b> A decreased titer of circulating AIAs was observed in the DR study category, suggesting that AIA may not contribute to the pathogenesis of DR.</p>","PeriodicalId":12568,"journal":{"name":"Future Science OA","volume":"10 1","pages":"FSO982"},"PeriodicalIF":2.5,"publicationDate":"2024-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11137838/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141179429","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
In silico and pharmacokinetic studies of glucomoringin from Moringa oleifera root for Alzheimer's disease like pathology. 从油辣木根中提取的葡萄糖络氨酸对类似阿尔茨海默氏症的病理学进行硅学和药代动力学研究。
IF 2.4
Future Science OA Pub Date : 2024-05-15 eCollection Date: 2024-01-01 DOI: 10.2144/fsoa-2023-0255
Chintalapati Manogna, Thirumal Margesan
{"title":"<i>In silico</i> and pharmacokinetic studies of glucomoringin from <i>Moringa oleifera</i> root for Alzheimer's disease like pathology.","authors":"Chintalapati Manogna, Thirumal Margesan","doi":"10.2144/fsoa-2023-0255","DOIUrl":"10.2144/fsoa-2023-0255","url":null,"abstract":"<p><p><b>Aim:</b> The aim of this research is to investigate the potential of glucomoringin, derived from <i>Moringa oleifera</i>, as a therapeutic agent for Alzheimer's disease through <i>in silico</i> analysis. <b>Materials & methods:</b> This study employs <i>in silico</i> or computational methodologies, including pkCSM, Swiss ADME, OSIRIS<sup>®</sup> property explorer, PASS online web resource and MOLINSPIRATION<sup>®</sup> software, to predict the pharmacokinetic characteristics and biological activity of glucomoringin. <b>Results & conclusion:</b> Molecular docking indicates strong binding to <i>I-1β</i> and the pharmacokinetic profile shows cytochrome P450 enzyme inhibition, prompting further research for dosing strategies. Toxicological predictions affirm safety, while bioactivity assessments demonstrate versatility in modulating essential pathways. glucomoringin's potential for Alzheimer's treatment, emphasizing the need for additional empirical research.</p>","PeriodicalId":12568,"journal":{"name":"Future Science OA","volume":"10 1","pages":"2340280"},"PeriodicalIF":2.4,"publicationDate":"2024-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11137837/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141179377","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Antimicrobial resistance pattern and uropathogens distribution in children visiting a referral hospital in Mogadishu. 摩加迪沙一家转诊医院就诊儿童的抗菌药耐药性模式和尿路病原体分布。
IF 2.5
Future Science OA Pub Date : 2024-05-15 eCollection Date: 2024-01-01 DOI: 10.2144/fsoa-2023-0298
Abdikarin Ahmed Mohamed, Yavuz Bastug, Cem Senol, Mohamed Muktar Kassim, Abdisalam Abdullahi Yusuf, Abdikarim Hussein Mohamed
{"title":"Antimicrobial resistance pattern and uropathogens distribution in children visiting a referral hospital in Mogadishu.","authors":"Abdikarin Ahmed Mohamed, Yavuz Bastug, Cem Senol, Mohamed Muktar Kassim, Abdisalam Abdullahi Yusuf, Abdikarim Hussein Mohamed","doi":"10.2144/fsoa-2023-0298","DOIUrl":"10.2144/fsoa-2023-0298","url":null,"abstract":"<p><p><b>Aim:</b> Studies concerning epidemiology and drug susceptibility patterns of pediatric urinary tract infection in developing countries are scarce. This study aimed to evaluate the antimicrobial resistance pattern and uropathogens distribution in children. <b>Method:</b> Four-year retrospective study included 840 participants in all pediatric age groups whose urine had been cultured. <b>Results:</b> The prevalence of culture-proven pediatric UTIs was 17.6% (148/840). <i>Escherichia coli</i> was the most common pathogen isolated from the cultures, accounting for (48%, 71/148), followed by <i>Klebsiella pneumoniae</i> (16.2%, 24/148). About 27% of the pathogens had a multidrug-resistant (MDR) pattern. A resistance rate against nitrofurantoin at 24.6%, fosfomycin at 15.2% and trimethoprim-sulfamethoxazole (SMX-TMP) at 79.7% was noted. <b>Conclusion:</b> <i>E. coli</i> and <i>Klebsiella pneumoniae</i> were the most common pathogens isolated.</p>","PeriodicalId":12568,"journal":{"name":"Future Science OA","volume":"10 1","pages":"FSO978"},"PeriodicalIF":2.5,"publicationDate":"2024-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11137854/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141179419","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Trans-femoral versus trans-carotid access for transcatheter aortic valve replacement: an updated systematic review and meta-analysis. 经股动脉与经颈动脉入路进行经导管主动脉瓣置换术：最新系统综述和荟萃分析。
IF 2.5
Future Science OA Pub Date : 2024-05-15 eCollection Date: 2024-01-01 DOI: 10.2144/fsoa-2023-0101
Naser Yamani, Syed Hasham Ali, Mahnoor Sadiq, Afeera B Ahmed, Kapil D Bhojwani, Vivek P Lohana, Saba Fatmah, Shazra Khalid, Hammad R Shamsi, Batool Zehra, Kaneez Fatima, Zulfiqar Q Baloch
{"title":"Trans-femoral versus trans-carotid access for transcatheter aortic valve replacement: an updated systematic review and meta-analysis.","authors":"Naser Yamani, Syed Hasham Ali, Mahnoor Sadiq, Afeera B Ahmed, Kapil D Bhojwani, Vivek P Lohana, Saba Fatmah, Shazra Khalid, Hammad R Shamsi, Batool Zehra, Kaneez Fatima, Zulfiqar Q Baloch","doi":"10.2144/fsoa-2023-0101","DOIUrl":"10.2144/fsoa-2023-0101","url":null,"abstract":"<p><p><b>Aim:</b> This meta-analysis aims to shed light on any primacy the <i>trans</i>-carotid (TC-TAVR) access may have over the <i>trans</i>-femoral access (TF-TAVR) for those undergoing transcatheter aortic valve replacement (TAVR). <b>Methods:</b> PubMed/MEDLINE and Cochrane Library were searched, from inception to March 2023 retrieving seven adjusted studies with a total of 6609 patients, of which 5048 underwent TF-TAVR while 1561 underwent TC-TAVR. <b>Results:</b> No divergence in risk of mortality, major bleeding or stroke/transient ischemic attack in TC-TAVR when compared with TF-TAVR was found. In TC-TAVR, the risk of vascular complications was low (OR: 0.51, 95% CI: 0.32-0.83, p = 0.003) as compared with TF-TAVR. <b>Conclusion:</b> As of this analysis, the viability of TC-TAVR as first alternative to TF-TAVR is plausible.</p>","PeriodicalId":12568,"journal":{"name":"Future Science OA","volume":"10 1","pages":"FSO930"},"PeriodicalIF":2.5,"publicationDate":"2024-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11137775/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141181795","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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