Frontiers in Human Neuroscience最新文献

{"title":"Effects of four non-invasive stimulations on swallowing function and quality of life of stroke patients-a network meta-analysis.","authors":"Xinyu Lin, Haojie Li, Xie Wu, Rui Huang","doi":"10.3389/fnhum.2025.1519660","DOIUrl":"10.3389/fnhum.2025.1519660","url":null,"abstract":"<p><strong>Background: </strong>Stroke is a sudden neurological disorder that causes severe neurological damage mainly due to lack of oxygen to brain cells as a result of interruption of blood flow to the brain. Dysphagia is a common problem in stroke patients, interfering with diet and nutrition and possibly leading to complications. About 50-80% of stroke patients experience dysphagia in the acute phase, which may lead to serious consequences such as aspiration and pneumonia. Therefore, improving swallowing function is essential to enhance patients' quality of life (QoL). Traditional rehab methods are limited, but non-invasive stimulation is safer and improves swallowing function through various mechanisms: pharyngeal electrical stimulation (PES) boosts cortical excitability and plasticity by stimulating pharyngeal nerves; neuro-muscular electrical stimulation (NmeS) enhances infrahyoid muscle strength and mobility with low-frequency pulses; repetitive transcranial magnetic stimulation (rTMS) promotes motor cortex remodeling; transcranial direct current stimulation (tDCS) increases neural activity in swallowing-related regions. These techniques are safe, easy to use, and show great potential for clinical application, needing further study.</p><p><strong>Methods: </strong>Six databases were systematically searched, and 17 randomized controlled trials with 788 stroke patients were finally included. The outcome indicators were swallowing function and QoL related indicators. Net meta-analysis was performed using Stata 17.0 to assess the relative effectiveness of each combined intervention and to test the consistency of direct and indirect evidence.</p><p><strong>Results: </strong>For swallowing function, rTMS [SMD = 5.10, 95% CI (3.20, 7.01), <i>p</i> < 0.0001, SUCRA = 87.3] showed the best results. For QoL, NmeS [SMD = 3.51, 95% CI (0.54, 6.47), <i>p</i> < 0.0001, SUCRA = 79.3] shows all its unique advantages.</p><p><strong>Conclusion: </strong>rTMS can effectively improve the swallowing function of stroke patients, while NmeS has the best effect in improving the QoL.</p><p><strong>Systematic review registration: </strong>https://www.crd.york.ac.uk/PROSPERO/view/CRD42024603146.</p>","PeriodicalId":12536,"journal":{"name":"Frontiers in Human Neuroscience","volume":"19 ","pages":"1519660"},"PeriodicalIF":2.4,"publicationDate":"2025-03-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11966035/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143779913","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Corrigendum: Dazzled by the mystery of mentalism: the cognitive neuroscience of mental athletes.","authors":"Andres Rieznik, Mikhail Lebedev, Mariano Sigman","doi":"10.3389/fnhum.2025.1569293","DOIUrl":"https://doi.org/10.3389/fnhum.2025.1569293","url":null,"abstract":"<p><p>[This corrects the article DOI: 10.3389/fnhum.2017.00287.].</p>","PeriodicalId":12536,"journal":{"name":"Frontiers in Human Neuroscience","volume":"19 ","pages":"1569293"},"PeriodicalIF":2.4,"publicationDate":"2025-03-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11947720/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143729517","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pilot study comparing effects of infrared neuromodulation and transcranial magnetic stimulation using magnetic resonance imaging.","authors":"Sophia A Bibb, Emily J Yu, M Fiona Molloy, John LaRocco, Patricia Resnick, Kevin Reeves, K Luan Phan, Sanjay Krishna, Zeynep M Saygin","doi":"10.3389/fnhum.2025.1514087","DOIUrl":"10.3389/fnhum.2025.1514087","url":null,"abstract":"<p><p>No prior work has directly compared the impacts of transcranial photobiomodulation (tPBM) and transcranial magnetic stimulation (TMS) on the human brain. This within-subjects pilot study compares the effects of tPBM and TMS of human somatomotor cortex on brain structural and functional connectivity. Eight healthy participants underwent four lab visits each, each visit consisting of a pre-stimulation MRI, stimulation or sham, and a post-stimulation MRI, respectively. Stimulation and sham sessions were counterbalanced across subjects. Collected measures included structural MRI data, functional MRI data from a finger-tapping task, resting state functional connectivity, and structural connectivity. Analyses indicated increased activation of the left somatomotor region during a right-hand finger-tapping task following both tPBM and TMS. Additionally, trending increases in left-lateralized functional and structural connectivity from M1 to thalamus were observed after tPBM, but not TMS. Thus, tPBM may be superior to TMS at inducing changes in connected nodes in the somatomotor cortex, although further research is warranted to explore the potential therapeutic benefits and clinical utility of tPBM.</p>","PeriodicalId":12536,"journal":{"name":"Frontiers in Human Neuroscience","volume":"19 ","pages":"1514087"},"PeriodicalIF":2.4,"publicationDate":"2025-03-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11966418/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143779914","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Editorial: Neural mechanisms of motor planning in assisted voluntary movement.","authors":"Suriya Prakash Muthukrishnan, Adham Atyabi","doi":"10.3389/fnhum.2025.1582214","DOIUrl":"10.3389/fnhum.2025.1582214","url":null,"abstract":"","PeriodicalId":12536,"journal":{"name":"Frontiers in Human Neuroscience","volume":"19 ","pages":"1582214"},"PeriodicalIF":2.4,"publicationDate":"2025-03-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11965887/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143779912","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Classifying mental motor tasks from chronic ECoG-BCI recordings using phase-amplitude coupling features.","authors":"Morgane Marzulli, Alexandre Bleuzé, Joe Saad, Felix Martel, Philippe Ciuciu, Tetiana Aksenova, Lucas Struber","doi":"10.3389/fnhum.2025.1521491","DOIUrl":"10.3389/fnhum.2025.1521491","url":null,"abstract":"<p><strong>Introduction: </strong>Phase-amplitude coupling (PAC), the modulation of high-frequency neural oscillations by the phase of slower oscillations, is increasingly recognized as a marker of goal-directed motor behavior. Despite this interest, its specific role and potential value in decoding attempted motor movements remain unclear.</p><p><strong>Methods: </strong>This study investigates whether PAC-derived features can be leveraged to classify different motor behaviors from ECoG signals within Brain-Computer Interface (BCI) systems. ECoG data were collected using the WIMAGINE implant during BCI experiments with a tetraplegic patient performing mental motor tasks. The data underwent preprocessing to extract complex neural oscillation features (amplitude, phase) through spectral decomposition techniques. These features were then used to quantify PAC by calculating different coupling indices. PAC metrics served as input features in a machine learning pipeline to evaluate their effectiveness in predicting mental tasks (idle state, right-hand movement, left-hand movement) in both offline and pseudo-online modes.</p><p><strong>Results: </strong>The PAC features demonstrated high accuracy in distinguishing among motor tasks, with key classification features highlighting the coupling of theta/low-gamma and beta/high-gamma frequency bands.</p><p><strong>Discussion: </strong>These preliminary findings hold significant potential for advancing our understanding of motor behavior and for developing optimized BCI systems.</p>","PeriodicalId":12536,"journal":{"name":"Frontiers in Human Neuroscience","volume":"19 ","pages":"1521491"},"PeriodicalIF":2.4,"publicationDate":"2025-03-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11936922/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143718605","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Case Report: Reversible alien hand syndrome caused by cerebral infarction.","authors":"Guo-Liang Lin, Xiao-Qian Yu, Han-Yu Cai, Ru-Yi Zhou, Xiao-Tian Li, Xiong Zhang, Jian-Yong Wang","doi":"10.3389/fnhum.2025.1551539","DOIUrl":"10.3389/fnhum.2025.1551539","url":null,"abstract":"<p><strong>Introduction: </strong>Alien hand syndrome (AHS) is a rare apraxia syndrome that may arise from several neurological disorders including stroke. Given the uncommon symptoms, stroke with AHS as its main manifestation often results in diagnostic challenges and treatment delays.</p><p><strong>Case presentation: </strong>We herein presented a case of post-stroke AHS caused by corpus callosum infarction. We prescribed him aspirin, clopidogrel, atorvastatin and memantine, and his AHS was remitted completely within 8 days.</p><p><strong>Conclusion: </strong>AHS is a rare manifestation of cerebral infarction that is generally reversible. Rapid identification of post-stroke AHS and early initiation of treatment are important to improve patient's prognosis.</p>","PeriodicalId":12536,"journal":{"name":"Frontiers in Human Neuroscience","volume":"19 ","pages":"1551539"},"PeriodicalIF":2.4,"publicationDate":"2025-03-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11936989/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143718602","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison metrics and power trade-offs for BCI motor decoding circuit design.","authors":"Joe Saad, Adrian Evans, Ilan Jaoui, Victor Roux-Sibillon, Emmanuel Hardy, Lorena Anghel","doi":"10.3389/fnhum.2025.1547074","DOIUrl":"10.3389/fnhum.2025.1547074","url":null,"abstract":"<p><p>Brain signal decoders are increasingly being used in early clinical trials for rehabilitation and assistive applications such as motor control and speech decoding. As many Brain-Computer Interfaces (BCIs) need to be deployed in battery-powered or implantable devices, signal decoding must be performed using low-power circuits. This paper reviews existing hardware systems for BCIs, with a focus on motor decoding, to better understand the factors influencing the power and algorithmic performance of such systems. We propose metrics to compare the energy efficiency of a broad range of on-chip decoding systems covering Electroencephalography (EEG), Electrocorticography (ECoG), and Microelectrode Array (MEA) signals. Our analysis shows that achieving a given classification rate requires an Input Data Rate (IDR) that can be empirically estimated, a finding that is helpful for sizing new BCI systems. Counter-intuitively, our findings show a negative correlation between the power consumption per channel (PpC) and the Information Transfer Rate (ITR). This suggests that increasing the number of channels can simultaneously reduce the PpC through hardware sharing and increase the ITR by providing new input data. In fact, for EEG and ECoG decoding circuits, the power consumption is dominated by the complexity of signal processing. To better understand how to minimize this power consumption, we review the optimizations used in state-of-the-art decoding circuits.</p>","PeriodicalId":12536,"journal":{"name":"Frontiers in Human Neuroscience","volume":"19 ","pages":"1547074"},"PeriodicalIF":2.4,"publicationDate":"2025-03-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11936894/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143718607","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Distinct and content-specific neural representations of self- and other-produced actions in joint piano performance.","authors":"Natalie Kohler, Anna M Czepiel, Örjan de Manzano, Giacomo Novembre, Peter E Keller, Arno Villringer, Daniela Sammler","doi":"10.3389/fnhum.2025.1543131","DOIUrl":"10.3389/fnhum.2025.1543131","url":null,"abstract":"<p><p>During ensemble performance, musicians predict their own and their partners' action outcomes to smoothly coordinate in real time. The neural auditory-motor system is thought to contribute to these predictions by running internal forward models that simulate self- and other-produced actions slightly ahead of time. What remains elusive, however, is whether and how own and partner actions can be represented <i>simultaneously</i> and <i>distinctively</i> in the sensorimotor system, and whether these representations are <i>content-specific</i>. Here, we applied multivariate pattern analysis (MVPA) to functional magnetic resonance imaging (fMRI) data of duetting pianists to dissociate the neural representation of self- and other-produced actions during synchronous joint music performance. Expert pianists played familiar right-hand melodies in a 3 T MR-scanner, in duet with a partner who played the corresponding left-hand basslines in an adjacent room. In half of the pieces, pianists were motorically familiar (or unfamiliar) with their partner's left-hand part. MVPA was applied in primary motor and premotor cortices (M1, PMC), cerebellum, and planum temporale of both hemispheres to classify which piece was performed. Classification accuracies were higher in left than right M1, reflecting the content-specific neural representation of self-produced right-hand melodies. Notably, PMC showed the opposite lateralization, with higher accuracies in the right than left hemisphere, likely reflecting the content-specific neural representation of other-produced left-hand basslines. Direct physiological support for the representational alignment of partners' M1 and PMC should be gained in future studies using novel tools like interbrain representational similarity analyses. Surprisingly, motor representations in PMC were similarly precise irrespective of familiarity with the partner's part. This suggests that expert pianists may generalize contents of familiar actions to unfamiliar pieces with similar musical structure, based on the auditory perception of the partner's part. Overall, these findings support the notion of parallel, distinct, and content-specific self and other internal forward models that are integrated within cortico-cerebellar auditory-motor networks to support smooth coordination in musical ensemble performance and possibly other forms of social interaction.</p>","PeriodicalId":12536,"journal":{"name":"Frontiers in Human Neuroscience","volume":"19 ","pages":"1543131"},"PeriodicalIF":2.4,"publicationDate":"2025-03-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11936940/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143718609","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Neuroplastic effects of transcranial alternating current stimulation (tACS): from mechanisms to clinical trials.","authors":"Desmond Agboada, Zhihe Zhao, Miles Wischnewski","doi":"10.3389/fnhum.2025.1548478","DOIUrl":"10.3389/fnhum.2025.1548478","url":null,"abstract":"<p><p>Transcranial alternating current stimulation (tACS) is a promising non-invasive neuromodulation technique with the potential for inducing neuroplasticity and enhancing cognitive and clinical outcomes. A unique feature of tACS, compared to other stimulation modalities, is that it modulates brain activity by entraining neural activity and oscillations to an externally applied alternating current. While many studies have focused on online effects during stimulation, growing evidence suggests that tACS can induce sustained after-effects, which emphasizes the potential to induce long-term neurophysiological changes, essential for therapeutic applications. In the first part of this review, we discuss how tACS after-effects could be mediated by four non-mutually exclusive mechanisms. First, spike-timing-dependent plasticity (STDP), where the timing of pre- and postsynaptic spikes strengthens or weakens synaptic connections. Second, spike-phase coupling and oscillation phase as mediators of plasticity. Third, homeostatic plasticity, emphasizing the importance of neural activity to operate within dynamic physiological ranges. Fourth, state-dependent plasticity, which highlights the importance of the current brain state in modulatory effects of tACS. In the second part of this review, we discuss tACS applications in clinical trials targeting neurological and psychiatric disorders, including major depressive disorder, schizophrenia, Parkinson's disease, and Alzheimer's disease. Evidence suggests that repeated tACS sessions, optimized for individual oscillatory frequencies and combined with behavioral interventions, may result in lasting effects and enhance therapeutic outcomes. However, critical challenges remain, including the need for personalized dosing, improved current modeling, and systematic investigation of long-term effects. In conclusion, this review highlights the mechanisms and translational potential of tACS, emphasizing the importance of bridging basic neuroscience and clinical research to optimize its use as a therapeutic tool.</p>","PeriodicalId":12536,"journal":{"name":"Frontiers in Human Neuroscience","volume":"19 ","pages":"1548478"},"PeriodicalIF":2.4,"publicationDate":"2025-03-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11936966/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143718612","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Contextual consistency promotes visual-haptic simultaneity perception.","authors":"Hiroyuki Umemura, Sunao Iwaki","doi":"10.3389/fnhum.2025.1550231","DOIUrl":"10.3389/fnhum.2025.1550231","url":null,"abstract":"<p><p>In this study, we investigate the influence of causality validity in the information provided to each of two sensory modalities on the integration of multisensory information. For the purpose, stimuli that simulated a causal event, a ball striking an object, were created using a head-mounted display and a haptic device. The visual position and motion of the object were aligned to the haptic feedback received by the observer. The haptic device delivered a vibration around the moment of impact. Three vibration directions were used to assess the effect of the validity of the causal relationship between the two events. Participants were asked to determine whether the collision of the ball and the vibration were simultaneous. The findings revealed that the participants were more likely to perceive the events as simultaneous when the direction of the vibration matched the ball's movement. These results suggest that valid causal consistency across different modalities enhances the binding of these signals as originating from a single source.</p>","PeriodicalId":12536,"journal":{"name":"Frontiers in Human Neuroscience","volume":"19 ","pages":"1550231"},"PeriodicalIF":2.4,"publicationDate":"2025-03-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11933114/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143709645","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}