General hospital psychiatry最新文献

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Diagnostic yield of laboratory testing in hospitalized older adults with altered mental status 精神状态改变的住院老年人实验室检查的诊断率
IF 4.1 2区 医学
General hospital psychiatry Pub Date : 2025-04-12 DOI: 10.1016/j.genhosppsych.2025.04.001
Kamber L. Hart , Kathleen M. McFadden , Sara B. Golas , Chana A. Sacks , Thomas H. McCoy
{"title":"Diagnostic yield of laboratory testing in hospitalized older adults with altered mental status","authors":"Kamber L. Hart ,&nbsp;Kathleen M. McFadden ,&nbsp;Sara B. Golas ,&nbsp;Chana A. Sacks ,&nbsp;Thomas H. McCoy","doi":"10.1016/j.genhosppsych.2025.04.001","DOIUrl":"10.1016/j.genhosppsych.2025.04.001","url":null,"abstract":"<div><h3>Background</h3><div>Altered mental status (AMS) is a common cause of hospitalization among older adults, with a wide range of potential etiologies. However, the diagnostic and therapeutic yield of routine laboratory testing in such patients is unknown.</div></div><div><h3>Methods</h3><div>In a retrospective cohort of inpatient hospital admissions to a large academic medical center from 2017 to 2022 of patients 65 years and older for whom the admitting diagnosis was AMS, we assessed laboratory testing for thyroid stimulating hormone (TSH), syphilis, vitamin B12, folate, vitamin C, vitamin D, zinc, niacin, and thiamine. We calculated the frequency of testing, rate of abnormal results, and rate of follow-up treatment.</div></div><div><h3>Results</h3><div>Of the 3169 patients, 2312 (73 %) received at least one designated lab, and overall, 12 % of labs were abnormal. Labs varied in frequency of use (0.2 % for niacin–66 % for TSH) and rate of abnormality (0 % for niacin–71 % for zinc). 16 % of abnormal index labs led to a new prescription at discharge. The most common tests – TSH, folate, and B12– were of relatively low diagnostic and therapeutic utility. Tests that were less common–zinc, vitamin D, and vitamin C–were more commonly abnormal. 3.8 % of patients tested for syphilis had abnormal results, and 72 % of patients with an abnormal result received treatment with penicillin during the index hospitalization.</div></div><div><h3>Conclusions</h3><div>These analyses suggest that commonly obtained labs in the workup of AMS have varied diagnostic and therapeutic utility. The contribution of observed laboratory abnormalities to a patients' AMS warrants further study to improve the delivery of high-value care.</div></div>","PeriodicalId":12517,"journal":{"name":"General hospital psychiatry","volume":"95 ","pages":"Pages 19-24"},"PeriodicalIF":4.1,"publicationDate":"2025-04-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143829360","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Sex differences in the comorbidity between attention deficit-hyperactivity disorder and posttraumatic stress disorder: A systematic literature review and meta-analysis 注意缺陷多动障碍与创伤后应激障碍共病的性别差异:系统文献回顾与荟萃分析
IF 4.1 2区 医学
General hospital psychiatry Pub Date : 2025-04-12 DOI: 10.1016/j.genhosppsych.2025.04.003
Julia Wilson , Doruntina Fida , Rie Maurer , Aleta Wiley , Therese Rajasekera , Primavera Spagnolo
{"title":"Sex differences in the comorbidity between attention deficit-hyperactivity disorder and posttraumatic stress disorder: A systematic literature review and meta-analysis","authors":"Julia Wilson ,&nbsp;Doruntina Fida ,&nbsp;Rie Maurer ,&nbsp;Aleta Wiley ,&nbsp;Therese Rajasekera ,&nbsp;Primavera Spagnolo","doi":"10.1016/j.genhosppsych.2025.04.003","DOIUrl":"10.1016/j.genhosppsych.2025.04.003","url":null,"abstract":"<div><h3>Objective</h3><div>Attention Deficit-Hyperactivity Disorder (ADHD) and Posttraumatic Stress Disorder (PTSD) are often comorbid and share a common core of symptoms. However, sex and gender-related factors significantly influence their prevalence, clinical presentation, and diagnosis. Here, we conducted a systematic literature review and meta-analysis to examine sex differences in ADHD/PTSD comorbidity during childhood and adulthood.</div></div><div><h3>Methods</h3><div>A scoping review of PsycINFO and PubMed yielded 13 eligible studies with complete outcome data. We conducted fixed-effects meta-analyses of the sex-stratified prevalence of ADHD/PTSD using pooled odds ratios (OR) with a 95 % confidence interval (CI). Fixed-effects subgroup analyses were performed using age as a subgroup. Effect size heterogeneity was assessed using the I<sup>2</sup> index and Cochran's Q test.</div></div><div><h3>Results</h3><div>In the whole sample (<em>N</em> = 13,585; F = 7005, M = 6580), the diagnosis of ADHD/PTSD was significantly higher in females than in males (OR = 1.32, <em>p</em> = 0.02). Between-study heterogeneity was low-to-moderate and not significant (I<sup>2</sup> = 41 %; <em>p</em> = 0.06), validating the fixed-effects model. Age-stratified subgroup analyses revealed higher ADHD/PTSD odds in females compared to males only in adult populations (OR = 1.41; <em>p =</em> 0.01). Additionally, females were more likely to be diagnosed with both disorders in studies where ADHD was the primary diagnosis (OR = 1.60; <em>p =</em> 0.002), and in studies employing structured clinical interviews as diagnostic tools (OR = 1.46; <em>p =</em> 0.009).</div></div><div><h3>Conclusions</h3><div>Our study is the first to show that the association between ADHD and PTSD is stronger in females, suggesting that ADHD may increase risk for PTSD in a sex-specific manner.</div></div>","PeriodicalId":12517,"journal":{"name":"General hospital psychiatry","volume":"95 ","pages":"Pages 32-39"},"PeriodicalIF":4.1,"publicationDate":"2025-04-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143847592","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Preoperative psychological distress is associated with mortality within 1 year of non-cardiac surgery 术前心理困扰与非心脏手术1年内的死亡率相关
IF 4.1 2区 医学
General hospital psychiatry Pub Date : 2025-04-11 DOI: 10.1016/j.genhosppsych.2025.04.002
Renée El-Gabalawy , Jordana L Sommer , Jitender Sareen , Corey S Mackenzie , P.J. Devereaux , Kailey Penner , Sadeesh Srinathan
{"title":"Preoperative psychological distress is associated with mortality within 1 year of non-cardiac surgery","authors":"Renée El-Gabalawy ,&nbsp;Jordana L Sommer ,&nbsp;Jitender Sareen ,&nbsp;Corey S Mackenzie ,&nbsp;P.J. Devereaux ,&nbsp;Kailey Penner ,&nbsp;Sadeesh Srinathan","doi":"10.1016/j.genhosppsych.2025.04.002","DOIUrl":"10.1016/j.genhosppsych.2025.04.002","url":null,"abstract":"<div><h3>Objective</h3><div>To characterize the association between preoperative psychological distress and postoperative complications at 30 days and mortality at 1 year in a non-cardiac surgery sample.</div></div><div><h3>Method</h3><div>Data were taken from a subsample of the VISION cohort study (<em>n</em> = 997; 2011–2012). Participants were scheduled to undergo major non-cardiac surgery under general or regional anesthesia. Participants self-reported past 30-day psychological distress on the day of surgery using the Kessler-6 (K6) Scale. Complications were assessed via interviews and/or chart reviews. Multivariable logistic regressions characterized the relationship between preoperative psychological distress and postoperative complications. Models were fitted for sociodemographics, surgery type, preoperative medical morbidity, and smoking.</div></div><div><h3>Results</h3><div>Among participants with a completed K6 (<em>n</em> = 938), 7.9 % experienced mortality within 1 year. After controlling for age, ethnicity, sex, surgery type, preoperative medical morbidity, and smoking, higher levels of preoperative psychological distress were associated with 30 day complications such as myocardial infarction, non-fatal cardiac arrest, leg/arm deep vein thrombosis/ pulmonary embolism, new acute renal failure, pneumonia, and congestive heart failure (AOR3 (3rd model), 1.12, [95 % CI, 1.02–1.22, <em>p</em> &lt; 0.05]) and 1-year mortality (AOR3, 1.09, [95 % CI, 1.02–1.18, p &lt; 0.05]). Sensitivity analyses demonstrate that the latter association was being driven by symptoms of depression (AOR3, 1.17 [95 % CI 1.04–1.33, p &lt; 0.05]) but not anxiety (AOR2, 0.94 [95 % CI, 0.61–1.62, <em>p</em> &gt; 0.05]).</div></div><div><h3>Conclusion</h3><div>Elevated preoperative distress increased the risk of 30-day complications and mortality at 1 year. These results underscore the need for future research to examine if supporting patients' mental health during the perioperative period can mitigate risk.</div><div><strong>Clinical Trial Registration</strong>: <span><span>clinicaltrials.gov</span><svg><path></path></svg></span>, no. <span><span>NCT00512109</span><svg><path></path></svg></span> (main VISION study).</div></div>","PeriodicalId":12517,"journal":{"name":"General hospital psychiatry","volume":"95 ","pages":"Pages 25-31"},"PeriodicalIF":4.1,"publicationDate":"2025-04-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143843212","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Analysis of gut microbiota and depression and anxiety: Mendelian randomization from three datasets 肠道菌群与抑郁和焦虑的分析:来自三个数据集的孟德尔随机化
IF 4.1 2区 医学
General hospital psychiatry Pub Date : 2025-03-22 DOI: 10.1016/j.genhosppsych.2025.03.012
Yaoyong Lai, Peng Xiong
{"title":"Analysis of gut microbiota and depression and anxiety: Mendelian randomization from three datasets","authors":"Yaoyong Lai,&nbsp;Peng Xiong","doi":"10.1016/j.genhosppsych.2025.03.012","DOIUrl":"10.1016/j.genhosppsych.2025.03.012","url":null,"abstract":"<div><h3>Background</h3><div>Emerging evidence supports gut microbiota's association with mental distress, particularly depression and anxiety, the microbiota-gut-brain axis was the believed to be the underlying mechanism. This study investigated the causal relationships between specific gut microbiota and depression and anxiety disorders using large-scale genome-wide association study (GWAS) data.</div></div><div><h3>Methods</h3><div>A two-sample bidirectional Mendelian randomization (MR) analysis was conducted to explore the causal effects of 211 microbial taxa on depression and anxiety across three large GWAS databases: FinnGen, Pan-UKBB, and PGC. Sensitive analyses were followed to validate the robustness of results. Random-effect meta-analysis was further performed to enhance the statistical power.</div></div><div><h3>Results</h3><div>The MR analysis revealed that the <em>Bifidobacteriales</em> (IVW: OR 0.90, 95 %CI 0.83 to 0.98) and <em>Bifidobacteriaceae</em> (IVW: OR 0.90, 95 %CI 0.83 to 0.98) had a protective effect against depression. <em>Clostridiales</em> (cML-MA: OR 0.88, 95 %CI 0.81 to 0.95) and <em>Parasutterella</em> (cML-MA: OR 0.75, 95 %CI 0.64 to 0.88) showed negative associations with depression. Increased abundance of <em>Oxalobacteraceae</em> (cML-MA: OR 1.78, 95 %CI 1.24 to 2.56), <em>Deltaproteobacteria</em> (cML-MA: OR 2.17, 95 %CI 1.38 to 3.40), and <em>Desulfovibrionales</em> (cML-MA: OR 2.22, 95 %CI 1.41 to 3.49) was associated with a higher risk of depression. For anxiety, protective effects were found for <em>Actinobacteria</em> (phylum: IVW: OR 0.83, 95 %CI 0.76 to 0.87; class: IVW: OR 0.84, 95 %CI 0.75 to 0.93), <em>Bifidobacteriales</em> (IVW: OR 0.80, 95 %CI 0.75 to 0.85), <em>Bifidobacteriaceae</em> (IVW: OR 0.80, 95 %CI 0.75 to 0.85) and <em>Bifidobacterium</em> [g] (IVW: OR 0.79, 95 %CI 0.74 to 0.84). <em>Lactobacillaceae [f]</em> (cML-MA: OR 1.18, 95 %CI 1.08 to 1.28), <em>Clostridia</em> [c] (cML-MA: OR 1.15, 95 %CI 0.1.06 to 1.26) and <em>Clostridiales</em> [o] (IVW: OR 1.15, 95 %CI 1.05 to 1.27) were associated with increased anxiety risk. Meta-analysis results indicated significant associations, particularly the protective effects of <em>Actinobacteria</em> (OR 0.90, 95 % CI, 0.83 to 0.98) and <em>Clostridiaceae1</em> (OR 0.91, 95 % CI, 0.83 to 0.99) on depression and several taxa on anxiety. No significant instrumental variables for depression or anxiety on gut microbiota were identified.</div></div><div><h3>Conclusions</h3><div>Our findings highlight specific gut microbiota that are associated with depression and anxiety, underscoring the causal relationships between these intestinal microbes and psychiatric disorders. These results suggest potential strategies for mitigating disease symptoms and improving quality of life through microbiome-targeted therapies. Further studies, including randomized controlled trials and investigations into sex-specific effects, are essential to validate and expand upon t","PeriodicalId":12517,"journal":{"name":"General hospital psychiatry","volume":"94 ","pages":"Pages 206-218"},"PeriodicalIF":4.1,"publicationDate":"2025-03-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143705528","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Trajectories of depressive symptoms and the risk of cardiovascular, dementia, and pulmonary events in older adults: Evidence from the English Longitudinal Study of Ageing 老年人抑郁症状的轨迹与心血管、痴呆和肺部事件的风险:来自英国老龄化纵向研究的证据
IF 4.1 2区 医学
General hospital psychiatry Pub Date : 2025-03-21 DOI: 10.1016/j.genhosppsych.2025.03.011
Qian Wu , Jing Xu , Xiaofeng Xu, Jiayin Yang
{"title":"Trajectories of depressive symptoms and the risk of cardiovascular, dementia, and pulmonary events in older adults: Evidence from the English Longitudinal Study of Ageing","authors":"Qian Wu ,&nbsp;Jing Xu ,&nbsp;Xiaofeng Xu,&nbsp;Jiayin Yang","doi":"10.1016/j.genhosppsych.2025.03.011","DOIUrl":"10.1016/j.genhosppsych.2025.03.011","url":null,"abstract":"<div><h3>Purpose</h3><div>This research investigates the relationship between patterns of depressive symptoms over time and the likelihood of developing cardiovascular disease, dementia, and pulmonary conditions.</div></div><div><h3>Methods</h3><div>We examined 11,577 participants aged 50 and older. Depressive symptoms were measured using the Center for Epidemiologic Studies Depression Scale-8 (CESD-8). Group-based trajectory modeling was employed to categorize patterns of depressive symptoms, while Cox proportional hazards models were used to estimate hazard ratios (HR) and 95 % confidence intervals (CI). Sensitivity analysis for missing data was conducted using multiple imputation and data deletion methods, and the model's timeliness and stability were evaluated through time sensitivity analysis.</div></div><div><h3>Results</h3><div>Five distinct trajectories of depressive symptoms were identified: consistently low (n = 3353), decreasing (n = 127), increasing (n = 128), fluctuating (n = 7674), and consistently high (n = 295). Compared to the consistently low group, individuals with consistently high depressive symptoms faced significantly elevated risks of cardiovascular disease (HR = 1.65, 95 % CI = 1.38–1.98, <em>P</em> = 0.00), dementia (HR = 2.09, 95 % CI = 1.16–3.79, <em>P</em> = 0.02), and pulmonary diseases (HR = 3.12, 95 % CI = 2.41–4.05, <em>P</em> = 0.00). Fluctuating and increasing trajectories were also associated with higher risks, while the decreasing trajectory correlated with a reduced risk of dementia (HR = 0.77, 95 % CI = 0.62–0.95, <em>P</em> = 0.01).</div></div><div><h3>Conclusion</h3><div>Long-term patterns of depressive symptoms are strongly linked to the development of cardiovascular disease, dementia, and pulmonary diseases.</div></div>","PeriodicalId":12517,"journal":{"name":"General hospital psychiatry","volume":"94 ","pages":"Pages 199-205"},"PeriodicalIF":4.1,"publicationDate":"2025-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143698140","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The heart's silver lining: Positive psychological well-being and health related quality of life in patients with heart failure 心脏的一线希望:心力衰竭患者积极的心理健康和健康相关的生活质量
IF 4.1 2区 医学
General hospital psychiatry Pub Date : 2025-03-20 DOI: 10.1016/j.genhosppsych.2025.03.014
Lisa-Marie Maukel , Karen Bouchard , Peter P. Liu , Jess G. Fiedorowicz , Victoria Bennett , Thais Coutinho , Heather Tulloch
{"title":"The heart's silver lining: Positive psychological well-being and health related quality of life in patients with heart failure","authors":"Lisa-Marie Maukel ,&nbsp;Karen Bouchard ,&nbsp;Peter P. Liu ,&nbsp;Jess G. Fiedorowicz ,&nbsp;Victoria Bennett ,&nbsp;Thais Coutinho ,&nbsp;Heather Tulloch","doi":"10.1016/j.genhosppsych.2025.03.014","DOIUrl":"10.1016/j.genhosppsych.2025.03.014","url":null,"abstract":"<div><h3>Objective</h3><div>Psychological distress, including depression, is linked to poor health outcomes in cardiovascular disease. Emerging evidence suggests that positive psychological well-being (PPWB), including optimism and purpose, may also impact health outcomes. However, the role of PPWB in heart failure (HF), a highly prevalent and progressive condition that severely affects health-related quality of life (HRQoL), remains unclear. This study explored the association between PPWB and HRQoL in patients with HF.</div></div><div><h3>Methods</h3><div>In this cross-sectional study, 101 patients with HF from a cardiac hospital completed validated measures of PPWB (BIT), depression (PHQ-9), disease-specific HRQoL (KCCQ-12), and generic HRQoL (SF-36). Spearman correlations and hierarchical multiple linear regression analyses were conducted, adjusting for sex, age, depression, and comorbidities (Charlson Comorbidity Index).</div></div><div><h3>Results</h3><div>Participants (mean age = 68.2 ± 9.9; 36 % female; 76 % NYHA class II) reported moderate PPWB (BIT = 3.7 ± 0.7), “fair” disease-specific HRQoL (KCCQ-12 Total score = 61.3 ± 23), and below-average generic HRQoL (SF-36 General Health = 36.2 ± 19.4). PPWB was significantly positively correlated with all KCCQ-12 and SF-36 subscales, with the strongest correlation for SF-36 General Health (<em>r</em> = 0.58, <em>p</em> &lt; .001). In multivariable models, higher BIT scores were associated with better HRQoL across domains, including KCCQ-12-QoL (β = 0.26, <em>p</em> = .012), KCCQ-12 Social Limitations (β = 0.26, <em>p</em> = .017), KCCQ-12 Total score (β = 0.21, <em>p</em> = .042), SF-36 Energy (β = 0.38, <em>p</em> &lt; .001), and SF-36 General Health (β = 0.48, <em>p</em> &lt; .001).</div></div><div><h3>Conclusion</h3><div>PPWB is significantly associated with both disease-specific and generic HRQoL in patients with HF, even after adjusting for comorbidities and depression. These findings highlight the importance of focusing on well-being, not just distress, in future HF research.</div></div>","PeriodicalId":12517,"journal":{"name":"General hospital psychiatry","volume":"95 ","pages":"Pages 11-18"},"PeriodicalIF":4.1,"publicationDate":"2025-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143769339","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The association between anhedonia and speech features in depression: A cross-sectional study 抑郁症患者快感缺乏与言语特征之间的关系:一项横断面研究
IF 4.1 2区 医学
General hospital psychiatry Pub Date : 2025-03-20 DOI: 10.1016/j.genhosppsych.2025.03.013
Qiushi Yang , Nanxi Li , Yiang Liu , Shuying Wang , Jingyao Ma , Jing Wang , Pengbo Liu , Zhiyang He , Gang Wang , Lei Feng
{"title":"The association between anhedonia and speech features in depression: A cross-sectional study","authors":"Qiushi Yang ,&nbsp;Nanxi Li ,&nbsp;Yiang Liu ,&nbsp;Shuying Wang ,&nbsp;Jingyao Ma ,&nbsp;Jing Wang ,&nbsp;Pengbo Liu ,&nbsp;Zhiyang He ,&nbsp;Gang Wang ,&nbsp;Lei Feng","doi":"10.1016/j.genhosppsych.2025.03.013","DOIUrl":"10.1016/j.genhosppsych.2025.03.013","url":null,"abstract":"<div><h3>Background</h3><div>Anhedonia is a core symptom of depression. Most anhedonia assessments rely on self-reporting, which does not accurately reflect hedonic capacity and is biased by individual subjectivity. Therefore, objective indicators are needed. Anhedonia may result in different speech features among depressive patients. Thus, speech features have become an emerging objective indicator in depression assessment. This study aims to investigate the relationship between anhedonia and speech features in individuals with depression by comparing the speech features of patients with and without anhedonia in a multitasking paradigm.</div></div><div><h3>Methods</h3><div>A total of 166 patients with depression were recruited for the study. Voice data were collected through the Verbal Fluency Test, Word reading, Video description, and Semi-structured Interviews. The primary analysis was performed using analysis of covariance (ANCOVA) and partial correlation analysis. We grouped patients based on the severity of depression and performed post-hoc <em>t</em>-tests or Mann-Whitney <em>U</em> tests for comparisons. The Benjamini-Hochberg method was used to control for False Discovery Rate in multiple comparisons.</div></div><div><h3>Results</h3><div>After adjustment for anxiety severity (as measured by the 7-item Generalized Anxiety Disorder Scale, GAD-7), no significant differences in speech features were observed between patients with or without anhedonia. Similarly, after controlling for depression severity (as measured by the 17-item Hamilton Depression Scale, HAMD-17), no significant correlation was found between speech features and the degree of anhedonia. Post hoc analyses showed that seventeen speech features were correlated with depression severity (|r| &lt; 0.3, small effect sizes), but no differences in speech features were found between patients with anhedonia and those without anhedonia within each subgroup based on depression severity.</div></div><div><h3>Conclusion</h3><div>Speech features do not differ significantly between patients with or without anhedonia at any level of depression severity. However, speech features were independently correlated with depression severity. Future studies may refine research methodology by optimizing speech task modules or assessing multidimensional prosodic features for more in-depth analysis.</div></div>","PeriodicalId":12517,"journal":{"name":"General hospital psychiatry","volume":"94 ","pages":"Pages 192-198"},"PeriodicalIF":4.1,"publicationDate":"2025-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143696900","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Mortality among veterans with serious mental illness who were lost to VHA care 患有严重精神疾病的退伍军人的死亡率,他们失去了VHA护理
IF 4.1 2区 医学
General hospital psychiatry Pub Date : 2025-03-20 DOI: 10.1016/j.genhosppsych.2025.03.017
Kristen M. Abraham , Kallisse R. Dent , Benjamin R. Szymanski , Stephanie L. Miller , John F. McCarthy
{"title":"Mortality among veterans with serious mental illness who were lost to VHA care","authors":"Kristen M. Abraham ,&nbsp;Kallisse R. Dent ,&nbsp;Benjamin R. Szymanski ,&nbsp;Stephanie L. Miller ,&nbsp;John F. McCarthy","doi":"10.1016/j.genhosppsych.2025.03.017","DOIUrl":"10.1016/j.genhosppsych.2025.03.017","url":null,"abstract":"","PeriodicalId":12517,"journal":{"name":"General hospital psychiatry","volume":"95 ","pages":"Pages 9-10"},"PeriodicalIF":4.1,"publicationDate":"2025-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143697060","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Immersive virtual reality and aging: Exploring the determinants of its effectiveness 沉浸式虚拟现实与老龄化:探索其有效性的决定因素。
IF 4.1 2区 医学
General hospital psychiatry Pub Date : 2025-03-18 DOI: 10.1016/j.genhosppsych.2025.03.015
Ria Resti Fauziah , Ari Metalin Ika Puspita , Ivo Yuliana , Fiena Saadatul Ummah , Siti Mufarochah , Erfan Ramadhani
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引用次数: 0
“Suicide prevention and substance use: The need for integrative and mechanism-informed interventions” “自杀预防和药物使用:综合和机制知情干预的必要性”。
IF 4.1 2区 医学
General hospital psychiatry Pub Date : 2025-03-18 DOI: 10.1016/j.genhosppsych.2025.03.016
Wikan Galuh Widyarto , Muslihati , I.M. Hambali , Adi Atmoko , Rizky Andana Pohan , Rohmat , Mochamad Nasichin Al Muiz , Muhamad Fatoni
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引用次数: 0
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