General hospital psychiatryPub Date : 2026-05-01Epub Date: 2026-04-30DOI: 10.1016/j.genhosppsych.2026.04.017
Yan-Wu Yang , Jing Yu , Li Gong , Mei-Ling Ge , Zhi Wan
{"title":"The triglyceride–glucose (TyG) index as an emerging biomarker for delirium: A systematic review and meta-analysis","authors":"Yan-Wu Yang , Jing Yu , Li Gong , Mei-Ling Ge , Zhi Wan","doi":"10.1016/j.genhosppsych.2026.04.017","DOIUrl":"10.1016/j.genhosppsych.2026.04.017","url":null,"abstract":"<div><h3>Background</h3><div>Delirium is a common and serious neuropsychiatric complication among acutely ill and surgical patients. Insulin resistance has been implicated in delirium vulnerability. The triglyceride–glucose (TyG) index, a simple surrogate marker of insulin resistance, has shown relevance in metabolic and neurological disorders, but its association with delirium remains unclear.</div></div><div><h3>Methods</h3><div>Following PRISMA guidelines, we performed a systematic review and meta-analysis of observational studies identified in PubMed, Embase, and Web of Science up to December 2025. Random-effects models were used to estimate pooled odds ratios (ORs) and 95% confidence intervals (CIs). Subgroup and sensitivity analyses evaluated robustness, and study quality was assessed using the QUIPS tool.</div></div><div><h3>Results</h3><div>Eight cohort studies including 25,462 participants (9739 delirium cases) were analyzed. Elevated TyG index was associated with an increased risk of delirium (pooled OR = 1.37, 95% CI: 1.29–1.46, <em>p</em> < 0.001), and each unit increase in TyG corresponded to a 29% higher risk (OR = 1.29, 95% CI: 1.21–1.37), with negligible heterogeneity (I<sup>2</sup> = 0%). The association remained consistent across subgroups defined by surgical status, metabolic conditions, and demographic factors, while a modestly stronger effect was observed in patients with heart failure (p for subgroup difference = 0.009). Sensitivity analyses confirmed the stability of results, and no publication bias was detected.</div></div><div><h3>Conclusions</h3><div>Elevated TyG index was associated with delirium risk across the included retrospective cohorts. As an accessible biomarker, TyG may facilitate early identification of patients at risk, reflecting the contribution of insulin resistance–related metabolic dysfunction to delirium pathogenesis.</div></div>","PeriodicalId":12517,"journal":{"name":"General hospital psychiatry","volume":"100 ","pages":"Pages 286-295"},"PeriodicalIF":3.7,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147849874","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
General hospital psychiatryPub Date : 2026-05-01Epub Date: 2026-05-05DOI: 10.1016/j.genhosppsych.2026.05.003
Vanessa Simiola , Kathryn K. Ridout , Catherine Erickson , Rowyda Kazan , Sixiang Nie , Maria P. Adolfson , Gregory E. Simon , Lisa R. Miller-Matero
{"title":"A pilot randomized controlled trial of an outreach intervention to improve depression treatment initiation among racial and ethnic groups","authors":"Vanessa Simiola , Kathryn K. Ridout , Catherine Erickson , Rowyda Kazan , Sixiang Nie , Maria P. Adolfson , Gregory E. Simon , Lisa R. Miller-Matero","doi":"10.1016/j.genhosppsych.2026.05.003","DOIUrl":"10.1016/j.genhosppsych.2026.05.003","url":null,"abstract":"<div><h3>Background</h3><div>Even after recognition of depression in primary care, rates of treatment initiation remain low, particularly among some racial and ethnic groups. This pilot randomized controlled trial examined the feasibility and preliminary efficacy of a tailored outreach intervention to improve depression treatment initiation.</div></div><div><h3>Methods</h3><div>Across two health systems, 309 adults from Asian, Native Hawaiian, Other Pacific Islander, Black or African American, and Hispanic backgrounds who received a new depression diagnosis in primary care but failed to initiate treatment within 30 days were randomized 1:1 to usual care or the outreach intervention. The intervention utilized patient portal messages or telephone contact based on depression severity, employing motivational interviewing techniques. The primary outcome was treatment initiation within 60-days post-randomization.</div></div><div><h3>Results</h3><div>Nearly three quarters (72%) of intervention participants were successfully reached. The intervention group demonstrated significantly higher treatment initiation rates compared to usual care (24.2% vs. 5.9%, <em>p</em> < .001), representing a four-fold increase. Participants who were reached were more likely to initiate treatment than those not reached (31.9% vs. 4.5%, p < .001). Both groups showed significant reductions in PHQ-9 scores at follow-up.</div></div><div><h3>Conclusions</h3><div>This pilot trial demonstrates that a staged outreach intervention using patient portals and telephone contact is feasible and shows promise for improving depression treatment initiation in racial and ethnic groups historically less likely to initiate treatment.</div></div>","PeriodicalId":12517,"journal":{"name":"General hospital psychiatry","volume":"100 ","pages":"Pages 277-283"},"PeriodicalIF":3.7,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147849869","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
General hospital psychiatryPub Date : 2026-05-01Epub Date: 2026-04-24DOI: 10.1016/j.genhosppsych.2026.04.012
Sean T. Lynch , Vidushi A. Purohit , Michael T. Mangold , Chelsea D. Eisenach , Lisa J. Cohen , Carisa M. Kymissis
{"title":"Clinical predictors of repeat intramuscular medication administration for acute agitation: A retrospective cohort study","authors":"Sean T. Lynch , Vidushi A. Purohit , Michael T. Mangold , Chelsea D. Eisenach , Lisa J. Cohen , Carisa M. Kymissis","doi":"10.1016/j.genhosppsych.2026.04.012","DOIUrl":"10.1016/j.genhosppsych.2026.04.012","url":null,"abstract":"<div><h3>Background</h3><div>Intramuscular (IM) antipsychotics are frequently used for acute agitation in psychiatric settings. While prior studies have focused on onset of sedation and adverse effects, the need for repeat IM medication, an important real-world marker of treatment effectiveness, has not been well characterized.</div></div><div><h3>Methods</h3><div>This retrospective study included adult patients who received IM haloperidol lactate or IM olanzapine for acute agitation between January 2020 and November 2022 at an academic medical center. The primary outcome was repeat IM medication administration within 24 h. Secondary analyses examined time to repeat administration. Sociodemographic, clinical, and treatment-related variables were compared. Multivariable logistic regression and Cox proportional hazards models were used to identify independent associations.</div></div><div><h3>Results</h3><div>Among 342 patients, 81 (23.7%) required repeat IM medication. Antipsychotic agent was not associated with repeat administration. In adjusted analyses, repeat medication was independently associated with co-administration of diphenhydramine (OR = 2.18), history of violence (OR = 1.88), and psychotic disorders (OR = 2.24), while substance use history (OR = 0.48) and inpatient setting (OR = 0.50) were associated with lower odds. Similar findings were observed in time-to-event analyses. Greater prior hospitalizations were associated with shorter time to repeat medication. Benzodiazepine co-administration was not independently associated with outcomes.</div></div><div><h3>Conclusions</h3><div>Repeat IM medication for acute agitation is common and appears to be driven primarily by patient-level factors rather than choice of antipsychotic agent. These findings highlight the importance of underlying illness severity and agitation phenotype in determining treatment response. Identifying patients at higher risk for escalation may inform targeted management strategies and resource allocation in acute psychiatric care settings.</div></div>","PeriodicalId":12517,"journal":{"name":"General hospital psychiatry","volume":"100 ","pages":"Pages 234-240"},"PeriodicalIF":3.7,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147768295","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
General hospital psychiatryPub Date : 2026-05-01Epub Date: 2026-04-30DOI: 10.1016/j.genhosppsych.2026.04.016
Chang-Chih Tsou , Dong-Wei Yang , Hung-Wen Chen
{"title":"Mood disorders and incident ICU delirium: Distinct risk profiles across clinical subgroups and diagnostic subtypes","authors":"Chang-Chih Tsou , Dong-Wei Yang , Hung-Wen Chen","doi":"10.1016/j.genhosppsych.2026.04.016","DOIUrl":"10.1016/j.genhosppsych.2026.04.016","url":null,"abstract":"<div><h3>Background</h3><div>Mood disorders are hypothesized to increase susceptibility to intensive care unit (ICU) delirium, but the evidence remains limited. This study evaluated the overall association and investigated risk heterogeneity across clinical subgroups and diagnostic subtypes.</div></div><div><h3>Methods</h3><div>Using the Medical Information Mart for Intensive Care (MIMIC)-IV database, we identified incident delirium via the Confusion Assessment Method for the ICU (CAM-ICU). Primary analysis employed 1:3 propensity score matching to estimate the overall association and explore risk variation across clinical subgroups. Secondary analysis used multivariable Cox regression on the full cohort to investigate risk heterogeneity across diagnostic subtypes.</div></div><div><h3>Results</h3><div>In 36,944 matched patients, mood disorders were independently associated with an increased risk of delirium (HR, 1.24; 95% CI, 1.19–1.30). Subgroup analyses within this cohort showed higher relative risk in patients typically considered low-risk: those younger than 65 years, without sepsis, and not receiving advanced critical care interventions. Notably, subtype analysis in the full cohort revealed a distinct risk gradient: bipolar disorder conferred the highest risk (HR, 1.54; 95% CI, 1.40–1.69), followed by major depressive disorder (HR, 1.39; 95% CI, 1.32–1.47), while other mood disorders showed no significant association (HR, 1.04; 95% CI, 0.97–1.11).</div></div><div><h3>Conclusion</h3><div>Mood disorders are independent risk factors for ICU delirium, particularly robust in younger or lower-acuity populations. This risk is primarily driven by bipolar disorder and major depressive disorder. Consequently, incorporating mood disorder history may serve as an additional marker of vulnerability to inform future delirium risk stratification for patients with major affective disorders, even without traditional high-risk characteristics.</div></div>","PeriodicalId":12517,"journal":{"name":"General hospital psychiatry","volume":"100 ","pages":"Pages 267-276"},"PeriodicalIF":3.7,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147849868","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
General hospital psychiatryPub Date : 2026-05-01Epub Date: 2026-05-03DOI: 10.1016/j.genhosppsych.2026.04.014
Xueyuan Wang, Wenhao Jiang, Yonggui Yuan
{"title":"Effects of light therapy on depression, anxiety and sleep quality in mental disorders: A systematic review and meta-analysis","authors":"Xueyuan Wang, Wenhao Jiang, Yonggui Yuan","doi":"10.1016/j.genhosppsych.2026.04.014","DOIUrl":"10.1016/j.genhosppsych.2026.04.014","url":null,"abstract":"<div><h3>Introduction</h3><div>Light therapy (LT) has become a frequently used treatment method for treating emotional disturbance (depression and anxiety) and sleep disorders due to its convenience, safety and low cost. Previous studies discovered that light, sleep and mood are closely related.</div></div><div><h3>Methods</h3><div>The whole process followed PRISMA 2020, all studies were searched in 5 databases from January 1st 2020 to June 30th 2025. The quality of studies was assessed by Risk of Bias Tool 2 and GRADE. The primary outcome was depression improvement, and secondary outcomes were anxiety improvement and sleep quality. Heterogeneity was assessed by <em>I</em><sup><em>2</em></sup> statistics. Subgroup analysis and meta-regression analysis were conducted to explore possible influencing factors. Sensitivity analysis was used to evaluate robustness.</div></div><div><h3>Results</h3><div>Depression improvement between two groups in patients with non-seasonal MDD or StD both reached a significant level (SMD = 0.35, 95% CI [0.11, 0.60], <em>p</em> = 0.0, <em>I</em><sup><em>2</em></sup> = 19.04%; SMD = 0.86, 95% CI [0.51, 1.21], <em>p</em> = 0.00, <em>I</em><sup><em>2</em></sup> = 68.49%, respectively). LT duration, illuminance, disease subtypes, and medication status were significantly influenced the effect of LT (<em>β</em> = 0.13, <em>p</em> = 0.02; <em>β</em> = −0.33, <em>p</em> = 0.04; <em>β</em> = −0.001, <em>p</em> = 0.02; <em>β</em> = −0.49, <em>p</em> = 0.02, respectively). LT also had a positive effect on anxiety, subjective sleep quality and daytime sleepiness.</div></div><div><h3>Conclusions</h3><div>LT had a positive effect on depression, anxiety and subjective sleep quality. LT duration, illuminance, disease subtype and medication status might be significant influencing factors.</div></div>","PeriodicalId":12517,"journal":{"name":"General hospital psychiatry","volume":"100 ","pages":"Pages 260-266"},"PeriodicalIF":3.7,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147836359","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
General hospital psychiatryPub Date : 2026-05-01Epub Date: 2026-04-24DOI: 10.1016/j.genhosppsych.2026.04.011
Victoria P. Schulte , Makayla Portley , Cristina Guasch , Danilo Rojas-Velasquez
{"title":"Extending the reach of inpatient consultation–liaison psychiatry: A systematic review of telepsychiatry in U.S. general hospitals","authors":"Victoria P. Schulte , Makayla Portley , Cristina Guasch , Danilo Rojas-Velasquez","doi":"10.1016/j.genhosppsych.2026.04.011","DOIUrl":"10.1016/j.genhosppsych.2026.04.011","url":null,"abstract":"<div><h3>Background</h3><div>Psychiatrist shortages and rural hospital gaps limit inpatient consultation–liaison (C-L) psychiatry in U.S. general hospitals. Telepsychiatry has expanded rapidly, yet implementation models, outcomes, and challenges of inpatient C-L telepsychiatry remain incompletely and inconsistently described.</div></div><div><h3>Methods</h3><div>We conducted a systematic review following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. We searched major medical, nursing, and psychological databases and <span><span>ClinicalTrials.gov</span><svg><path></path></svg></span> (1990–November 2025) for English-language studies of adult inpatient C-L telepsychiatry in U.S. general hospitals. Two reviewers independently screened, extracted data, and appraised quality with Joanna Briggs Institute tools.</div></div><div><h3>Results</h3><div>Seventeen studies met inclusion criteria with no randomized or quasi-experimental trials. Most programs used hub-and-spoke models linking community hospitals with academic C-L services, supported by local staff for technology and workflow. Consults commonly addressed mood and substance use disorders, delirium or other neurocognitive syndromes, and capacity, and often led to medication changes. Operational outcomes suggested improved access and shorter time-to-consult, while some requests were triaged to in-person care when clinical or technical factors limited virtual assessment. Clinicians generally viewed inpatient telepsychiatry as feasible but described difficulty assessing delirium and agitation and limited interpreter integration; patient-centered outcomes, cost, and equity measures were rarely reported.</div></div><div><h3>Conclusions</h3><div>Inpatient C-L telepsychiatry appears feasible across diverse U.S. hospitals and can extend psychiatric expertise to underserved settings while preserving key liaison functions when supported by clear triage pathways, in-person backstops, and coordination. However, evidence is largely observational; rigorous multi-site comparative studies with standardized clinical, operational, cost, and equity outcomes are needed.</div></div>","PeriodicalId":12517,"journal":{"name":"General hospital psychiatry","volume":"100 ","pages":"Pages 241-250"},"PeriodicalIF":3.7,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147768271","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
General hospital psychiatryPub Date : 2026-05-01Epub Date: 2026-04-25DOI: 10.1016/j.genhosppsych.2026.04.013
Hsiu-Ching Li , Chi-Hung Huang , Wei-Che Chiu , Yu-Chung Wei , Chia-Chi Lin , Zi-Jing Pan
{"title":"Overlapping but distinct: delirium and catatonia-related features in critically ill patients","authors":"Hsiu-Ching Li , Chi-Hung Huang , Wei-Che Chiu , Yu-Chung Wei , Chia-Chi Lin , Zi-Jing Pan","doi":"10.1016/j.genhosppsych.2026.04.013","DOIUrl":"10.1016/j.genhosppsych.2026.04.013","url":null,"abstract":"<div><h3>Objective</h3><div>To characterize patient-level and patient-day–level overlap between delirium and catatonia-related features in critically ill patients during intensive care unit (ICU) stay.</div></div><div><h3>Methods</h3><div>In this prospective observational study conducted in a cardiovascular ICU, adult patients underwent daily paired neuropsychiatric assessments throughout ICU stay. Delirium was screened using the Intensive Care Delirium Screening Checklist (ICDSC) and catatonia-related features using the Bush–Francis Catatonia Screening Instrument (BFCSI). Assessments were performed once daily when patients were sufficiently arousable (Richmond Agitation–Sedation Scale ≥ −3). Overlap was summarized at patient and patient-day levels using descriptive statistics and Cohen's κ.</div></div><div><h3>Results</h3><div>Among 44 patients, delirium and catatonia-related features occurred both independently and concurrently. At the patient level, 6 patients (13.6%) were delirium only, 4 (9.1%) were catatonia only, and 6 (13.6%) experienced both. Concordance was fair (κ =0.40; 95% CI, 0.09–0.70). Across 247 ICU days, 17 (6.9%) were delirium only, 18 (7.3%) were catatonia only, and 13 (5.3%) were both, with fair concordance (κ =0.35; 95% CI, 0.18–0.52). Delirium-positive days increased across Sequential Organ Failure Assessment (SOFA) categories, whereas catatonia-related features were observed across severity strata without a consistent severity-dependent gradient.</div></div><div><h3>Conclusions</h3><div>Delirium and catatonia-related features demonstrate partial and dynamic overlap during critical illness. The differential associations with illness severity suggest that these represent related but distinguishable neuropsychiatric phenomena in the ICU.</div></div><div><h3>Trial registration</h3><div>This study is a prospective observational study and not a clinical trial; therefore, trial registration was not required.</div></div>","PeriodicalId":12517,"journal":{"name":"General hospital psychiatry","volume":"100 ","pages":"Pages 251-257"},"PeriodicalIF":3.7,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147836369","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Prevalence and incidence of depressive, anxiety, and insomnia symptoms in perimenopausal and postmenopausal women: Systematic review and meta-analysis.","authors":"Ilambaridhi Balasubramanian, Bandita Abhijita, Yuvaraj Krishnamoorthy, Jilisha Gnanadhas, Mirza J Beg, Vikas Menon","doi":"10.1016/j.genhosppsych.2026.03.010","DOIUrl":"https://doi.org/10.1016/j.genhosppsych.2026.03.010","url":null,"abstract":"<p><strong>Background: </strong>Menopausal transition represents a vulnerable stage for women's mental health. Yet, global epidemiological estimates of psychological morbidity across perimenopausal and postmenopausal periods remain limited.</p><p><strong>Objective: </strong>To systematically synthesise the pooled prevalence and incidence of depressive, anxiety, and insomnia symptoms in perimenopausal and postmenopausal women.</p><p><strong>Methods: </strong>We systematically searched MEDLINE, EMBASE, and SCOPUS until December 2024 for cross-sectional and cohort studies reporting point or period prevalence or incidence of depressive, anxiety, or insomnia symptoms. Random-effects models generated pooled estimates with 95% confidence intervals (CI). Subgroup analyses were performed by assessment type and duration of menopause. Risk of bias was evaluated using the Newcastle-Ottawa Scale.</p><p><strong>Results: </strong>A total of 102 studies (N = 1,141,955) were meta-analysed. The pooled point prevalence of depressive symptoms was 32% (95% CI, 26%-37%) in perimenopausal and 30% (95% CI, 27%-34%) in postmenopausal women; the period prevalence was 24% (95% CI, 20%-29%) and 19% (95% CI, 15%-23%), respectively. The corresponding incidence rates were 13% (95% CI, 7%-22%) and 5% (95% CI, 2%-10%), respectively. Anxiety point prevalence was 29% (95% CI, 15%-45%) in perimenopausal and 39% (95% CI, 22%-57%) in postmenopausal women. Point prevalence of insomnia was 42% (95% CI, 34%-50%) and 27% (95% CI, 19%-37%) among postmenopausal and perimenopausal women, respectively. Subgroup analyses revealed higher rates with screening instruments and during early menopause. Most studies had a low or moderate risk of bias.</p><p><strong>Conclusions: </strong>Nearly one in three women experiences depressive, anxiety, and/or insomnia symptoms around menopausal transition, underscoring the need for routine mental health screening and integrated multidisciplinary care.</p>","PeriodicalId":12517,"journal":{"name":"General hospital psychiatry","volume":" ","pages":""},"PeriodicalIF":3.7,"publicationDate":"2026-03-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147633039","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}