General hospital psychiatry最新文献

{"title":"Associations of exercise snacks with cognitive function among older adults in NHANES 2011–2014","authors":"Junyu Wu ,&nbsp;Yufei Wang ,&nbsp;Peng Qiu ,&nbsp;Youqiang Li","doi":"10.1016/j.genhosppsych.2025.03.005","DOIUrl":"10.1016/j.genhosppsych.2025.03.005","url":null,"abstract":"<div><h3>Background</h3><div>With an aging global population, dementia incidence is rapidly increasing, affecting 50 million people worldwide. While physical activity has been linked to cognitive enhancement, the specific effects of intermittent short bouts of exercise, termed ‘exercise snacks’ (ES), on cognitive function (CF) in older adults are not well understood.</div></div><div><h3>Methods</h3><div>We analyzed data from 2549 adults aged ≥60 years from the 2011–2014 National Health and Nutrition Examination Survey cycles. CF was assessed using standardized tests, and physical activity data were obtained from accelerometer measurements. ES was defined as 2–5 min of moderate-to-vigorous physical activity. Regression analyses, smoothed curve fitting, and threshold effect analyses were conducted, adjusting for relevant covariates.</div></div><div><h3>Results</h3><div>Significant positive associations were found between CF and daily average Monitor-Independent Movement Summary specific to ES (MIMS-ES: <em>β</em> = 0.0001, 95 % CI: 0.0001–0.0001) and total time spent on ES (Time-ES: <em>β</em> = 0.0021, 95 % CI: 0.0014–0.0029). Each additional unit of MIMS-ES and each minute of ES daily increased CF scores by 0.0001 and 0.0021 points, respectively, suggesting benefits for cognitive health in aging populations. An inverted U-shaped relationship was observed, with inflection points at 2522.82 units/day for MIMS-ES and 91.57 min/day for Time-ES, indicating diminishing cognitive benefits beyond these thresholds.</div></div><div><h3>Conclusion</h3><div>ES was associated with higher CF. This practical form of physical activity offers an effective strategy for cognitive health and mitigating age-related decline, presenting a more accessible alternative to traditional continuous exercise.</div></div>","PeriodicalId":12517,"journal":{"name":"General hospital psychiatry","volume":"94 ","pages":"Pages 167-173"},"PeriodicalIF":4.1,"publicationDate":"2025-03-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143628760","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Transforming mental health care in the Arab World: A scoping review of Arab TMS studies for psychiatric disorders","authors":"Mohammed Qutishat ,&nbsp;Salim Al-Huseini ,&nbsp;Mohammed Al-Balushi","doi":"10.1016/j.genhosppsych.2025.03.008","DOIUrl":"10.1016/j.genhosppsych.2025.03.008","url":null,"abstract":"<div><h3>Background</h3><div>The mental health landscape in the Arab world has undergone significant changes, highlighting the need for innovative treatment methods like Transcranial Magnetic Stimulation (TMS). Historically, mental health was stigmatized and under-addressed, leading to a reliance on traditional remedies.</div></div><div><h3>Method</h3><div>This scoping review utilized the Arksey &amp; O'Malley framework to examine TMS's application, effectiveness, and challenges in treating psychiatric disorders in Arab countries. A comprehensive search was conducted across six databases, and studies published between 2018 and 2024 were included, focusing on various mental health conditions treated with rTMS.</div></div><div><h3>Results</h3><div>Nineteen studies were reviewed, with findings indicating that TMS is a promising, non-invasive alternative to traditional treatments like electroconvulsive therapy. Benefits included minimal side effects, quick sessions, complementary treatment options, and cumulative therapeutic effects. However, high costs, lack of trained professionals, and social stigma were significant challenges.</div></div><div><h3>Discussion</h3><div>The integration of rTMS can enhance mental health care in the region. Addressing economic barriers and increasing awareness through public campaigns could improve accessibility and acceptance of rTMS as a viable treatment option.</div></div><div><h3>Conclusion</h3><div>The findings underscore the need for further research, training for healthcare providers, and public awareness campaigns to promote TMS, ultimately contributing to a healthier societal perspective on mental well-being.</div></div>","PeriodicalId":12517,"journal":{"name":"General hospital psychiatry","volume":"94 ","pages":"Pages 159-166"},"PeriodicalIF":4.1,"publicationDate":"2025-03-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143628815","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Investigating the impact of endocrine-disrupting compounds on antepartum mental health at the Nexus of genetic insights and maternal-fetal outcomes: A prospective study","authors":"S. Aishwarya ,&nbsp;V.M. Vinodhini ,&nbsp;P. Renuka ,&nbsp;R. Arul Saravanan ,&nbsp;M. Anuradha ,&nbsp;T. Gomathi ,&nbsp;V. Amuthavalli","doi":"10.1016/j.genhosppsych.2025.03.009","DOIUrl":"10.1016/j.genhosppsych.2025.03.009","url":null,"abstract":"<div><h3>Background</h3><div>Antepartum depression arises from hormonal, environmental, and genetic factors. Endocrine-disrupting compounds (EDCs) disrupt the endocrine system, increasing vulnerability to depressive symptoms. Genetic variations, particularly in estrogen receptor (ER) pathways, are linked to peripartum depression, with EDCs exposure exacerbating these effects by further disrupting estrogen pathways. Additionally, EDCs exposure in antepartum women is associated with adverse maternal and fetal outcomes. Hence, study aims to evaluate the relationship between EDCs and genetic polymorphisms with antepartum depressive symptoms and assess the impact of EDCs and antepartum depressive symptoms on maternal and fetal outcomes.</div></div><div><h3>Materials and methods</h3><div>We conducted a prospective cohort study to evaluate depressive symptoms during pregnancy in 400 women between 28 and 40 weeks of gestation, utilizing the Edinburgh Postnatal Depression Scale (EPDS). Women with elevated EPDS scores and matched controls were assessed for urinary bisphenol A and methylparaben levels, along with ER1 gene polymorphism using Tetra-ARMS PCR. The cohort group was followed to document maternal-fetal outcomes, with statistical analyses performed using SPSS.</div></div><div><h3>Results</h3><div>Twenty-three percent of antepartum women exhibited depressive symptoms. A linear regression analysis indicated that a one-unit increase in log bisphenol A levels corresponded to a 1.1-point increase in EPDS-measured depressive symptom scores. ER1 polymorphisms (A/A and T/A genotypes) and the frequency of the A allele correlate with an increased risk of experiencing antepartum depressive symptoms. Elevated EPDS scores correlated with pregnancy-induced hypertension, anemia, hypothyroidism, and fetal distress. Notably, bisphenol A and methylparaben levels were higher in homozygous genotypes, with bisphenol A linked to maternal anemia, hypothyroidism, and fetal distress, while methylparaben was associated with maternal anemia and fetal distress.</div></div><div><h3>Conclusion</h3><div>Nearly a quarter of antepartum women displayed depressive symptoms, correlating with elevated endocrine disruptor levels. Higher bisphenol A and methylparaben levels were observed in individuals with mutant genotypes, indicating gene-environment interactions with antepartum depressive symptoms. The observed association of EDCs with maternal anemia, hypothyroidism, and fetal distress highlights the possible effect of EDC on maternal and fetal health.</div></div>","PeriodicalId":12517,"journal":{"name":"General hospital psychiatry","volume":"94 ","pages":"Pages 174-183"},"PeriodicalIF":4.1,"publicationDate":"2025-03-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143637543","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Anxiety and depression in patients with an implantable cardioverter defibrillator: Do personality and ICD expectations play a role?","authors":"S.S. Pedersen ,&nbsp;J.B. Johansen ,&nbsp;J.C. Nielsen ,&nbsp;C.E. Larroude ,&nbsp;S. Riahi ,&nbsp;T.M. Melchior ,&nbsp;M. Vinther ,&nbsp;S.J. Skovbakke ,&nbsp;O. Skov","doi":"10.1016/j.genhosppsych.2025.03.002","DOIUrl":"10.1016/j.genhosppsych.2025.03.002","url":null,"abstract":"<div><h3>Objective</h3><div>To examine if Type D personality and expectations towards implantable cardioverter defibrillator (ICD) therapy are associated with symptoms of anxiety and depression in ICD patients one year after ICD implantation.</div></div><div><h3>Methods</h3><div>Secondary analysis of first-time ICD patients from the national Danish ACQUIRE-ICD trial. Multiple linear regression analyses were conducted, adjusting for baseline outcome scores and potential confounders.</div></div><div><h3>Results</h3><div>Of the 478 patients in the study, the mean age was 59.6 ± 11.6 and the majority were male (<em>n</em> = 397; 83.1 %). 73 patients (15.3 %) had a Type D personality. Baseline mean scores on positive expectations towards ICD implantation were 12.8 ± 3.18 and mean scores on negative expectations were 5.37 ± 3.30. Patients were followed up after one year with 352 (73.6 %) patients providing complete follow-up data. Type D personality was independently associated with 12 months depression scores (B = 2.44, 95 % CI [1.34, 3.55], <em>p</em> &lt; .001) and 12 months anxiety scores (B = 1.92, 95 % CI [1.02, 2.82], p &lt; .001), over and above initial distress levels. Neither positive nor negative ICD expectations were significantly associated with anxiety or depression at 12 months follow-up.</div></div><div><h3>Conclusion</h3><div>Type D personality was predictive of increased anxiety and depression symptoms from ICD implantation to one-year follow-up. No significant association was found for ICD expectations.</div></div>","PeriodicalId":12517,"journal":{"name":"General hospital psychiatry","volume":"94 ","pages":"Pages 145-149"},"PeriodicalIF":4.1,"publicationDate":"2025-03-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143619113","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Optimism and quality of life post-PCI: Integrating psychological resilience into holistic rehabilitation","authors":"Mila Yunita ,&nbsp;Palasara Brahmani Laras ,&nbsp;Abdul Hadi ,&nbsp;Eka Aryani ,&nbsp;Fiki Prayogi ,&nbsp;Oka Rahmawati Istiqomah","doi":"10.1016/j.genhosppsych.2025.03.007","DOIUrl":"10.1016/j.genhosppsych.2025.03.007","url":null,"abstract":"","PeriodicalId":12517,"journal":{"name":"General hospital psychiatry","volume":"95 ","pages":"Pages 3-4"},"PeriodicalIF":4.1,"publicationDate":"2025-03-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143644204","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"An updated psychometric evaluation of the Brief Betrayal Trauma Survey","authors":"Hong Wang Fung ,&nbsp;Grace Wing Ka Ho ,&nbsp;Stanley Kam Ki Lam ,&nbsp;Colin A. Ross ,&nbsp;Edward K.S. Wang ,&nbsp;Chak Hei Ocean Huang ,&nbsp;Cherry Tin Yan Cheung ,&nbsp;Henry Wai-Hang Ling ,&nbsp;Anson Kai Chun Chau ,&nbsp;Janet Yuen-Ha Wong","doi":"10.1016/j.genhosppsych.2025.03.006","DOIUrl":"10.1016/j.genhosppsych.2025.03.006","url":null,"abstract":"","PeriodicalId":12517,"journal":{"name":"General hospital psychiatry","volume":"94 ","pages":"Pages 142-144"},"PeriodicalIF":4.1,"publicationDate":"2025-03-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143619701","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Psychological resilience in cardiac care: The case for optimism","authors":"Fiki Prayogi ,&nbsp;Palasara Brahmani Laras ,&nbsp;Ade Sri Madona ,&nbsp;Arlina Yuza ,&nbsp;Risa Yulisna ,&nbsp;Afdhal Ilahi ,&nbsp;Erfan Ramadhani ,&nbsp;Ramtia Darma Putri","doi":"10.1016/j.genhosppsych.2025.03.004","DOIUrl":"10.1016/j.genhosppsych.2025.03.004","url":null,"abstract":"","PeriodicalId":12517,"journal":{"name":"General hospital psychiatry","volume":"95 ","pages":"Pages 1-2"},"PeriodicalIF":4.1,"publicationDate":"2025-03-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143642912","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"AI-driven report-generation tools in mental healthcare: A review of commercial tools","authors":"Ayoub Bouguettaya ,&nbsp;Victoria Team ,&nbsp;Elizabeth M. Stuart ,&nbsp;Elias Aboujaoude","doi":"10.1016/j.genhosppsych.2025.02.018","DOIUrl":"10.1016/j.genhosppsych.2025.02.018","url":null,"abstract":"<div><div>Artificial intelligence (AI) systems are increasingly being integrated in clinical care, including for AI-powered note-writing. We aimed to develop and apply a scale for assessing mental health electronic health records (EHRs) that use large language models (LLMs) for note-writing, focusing on their features, security, and ethics. The assessment involved analyzing product information and directly querying vendors about their systems. On their websites, the majority of vendors provided comprehensive information on data protection, privacy measures, multi-platform availability, patient access features, software update history, and Meaningful Use compliance. Most products clearly indicated the LLM's capabilities in creating customized reports or functioning as a co-pilot. However, critical information was often absent, including details on LLM training methodologies, the specific LLM used, bias correction techniques, and methods for evaluating the evidence base. The lack of transparency regarding LLM specifics and bias mitigation strategies raises concerns about the ethical implementation and reliability of these systems in clinical practice. While LLM-enhanced EHRs show promise in alleviating the documentation burden for mental health professionals, there is a pressing need for greater transparency and standardization in reporting LLM-related information. We propose recommendations for the future development and implementation of these systems to ensure they meet the highest standards of security, ethics, and clinical care.</div></div>","PeriodicalId":12517,"journal":{"name":"General hospital psychiatry","volume":"94 ","pages":"Pages 150-158"},"PeriodicalIF":4.1,"publicationDate":"2025-03-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143619700","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Plasma human cartilage glycoprotein-39 and depressive symptoms among acute ischemic stroke patients","authors":"Ziyi Wang ,&nbsp;Kaixin Zhang ,&nbsp;Chongke Zhong ,&nbsp;Zhengbao Zhu ,&nbsp;Xiaowei Zheng ,&nbsp;Pinni Yang ,&nbsp;Bizhong Che ,&nbsp;Yaling Lu ,&nbsp;Yonghong Zhang ,&nbsp;Tian Xu","doi":"10.1016/j.genhosppsych.2025.03.003","DOIUrl":"10.1016/j.genhosppsych.2025.03.003","url":null,"abstract":"<div><h3>Objective</h3><div>Our study aimed at evaluating the association between plasma human cartilage glycoprotein-39 (YKL-40) and depressive symptoms at 3 months among acute ischemic stroke patients.</div></div><div><h3>Methods</h3><div>Plasma YKL-40 levels were measured in 619 patients with ischemic stroke who participated in the China Antihypertensive Trial in Acute Ischemic Stroke (CATIS). The patients' depressive symptoms at 3 months after stroke were assessed using the Hamilton Rating Scale for Depression (HRSD-24).</div></div><div><h3>Results</h3><div>During the 3-month follow-up period, 242 (39.1 %) participants were classified as experiencing depressive symptoms. Patients in the highest quartile of YKL-40 had a 1.98-fold (95 %CI: 1.19–3.30, <em>P</em> for trend = 0.02) risk of depressive symptoms compared with those in the lowest quartile. Per 1-SD increase of logarithm-transformed YKL-40 was associated with a 32 % (95 % CI: 10 %–58 %) increased risk for the depressive symptoms. The multiple-adjusted spline regression model confirmed dose-response relationships between YKL-40 levels and depressive symptoms (<em>P</em> for linearity = 0.02). Adding YKL-40 to a model containing conventional risk factors significantly improved the discriminatory power (area under the receiver operating characteristic curve improved by 0.02, <em>P</em> = 0.04) and reclassification power for depressive symptoms (net reclassification improvement = 18.77 %, <em>P</em> = 0.02; integrated discrimination improvement = 1.30 %, <em>P</em> = 0.005).</div></div><div><h3>Conclusions</h3><div>Elevated YKL-40 levels might be a potential risk marker of depressive symptoms at 3 months among acute ischemic stroke patients.</div><div><strong>Registration:</strong> URL: <span><span>https://www.clinicaltrials.gov</span><svg><path></path></svg></span>; Unique identifier: <span><span>NCT01840072</span><svg><path></path></svg></span>.</div></div>","PeriodicalId":12517,"journal":{"name":"General hospital psychiatry","volume":"94 ","pages":"Pages 120-125"},"PeriodicalIF":4.1,"publicationDate":"2025-03-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143580254","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Existential distress in advanced cancer: A cohort study","authors":"Rebecca Philipp ,&nbsp;Charlotte Walbaum ,&nbsp;Uwe Koch ,&nbsp;Karin Oechsle ,&nbsp;Thies Daniels ,&nbsp;Friederike Helmich ,&nbsp;Marlitt Horn ,&nbsp;Johanna Junghans ,&nbsp;David Kissane ,&nbsp;Guntram Lock ,&nbsp;Christopher Lo ,&nbsp;Anne Mruk-Kahl ,&nbsp;Volkmar Müller ,&nbsp;Martin Reck ,&nbsp;Georgia Schilling ,&nbsp;Kornelius Schulze ,&nbsp;Johann von Felden ,&nbsp;Carsten Bokemeyer ,&nbsp;Martin Härter ,&nbsp;Sigrun Vehling","doi":"10.1016/j.genhosppsych.2025.02.023","DOIUrl":"10.1016/j.genhosppsych.2025.02.023","url":null,"abstract":"<div><h3>Objective</h3><div>Clinically significant existential distress may impair quality of life and communication about illness. We investigated the presence of existential distress in the form of demoralization, death anxiety, and dignity-related distress, and its co-occurrence with mental disorders in patients with advanced cancer.</div></div><div><h3>Methods</h3><div>We conducted structured clinical interviews and administered self-report questionnaires to assess existential distress and mental disorders. We recruited patients with different Union for International Cancer Control (UICC) stage IV solid tumors from in- and outpatient oncology and palliative care settings.</div></div><div><h3>Results</h3><div>A total of 671 patients completed assessments (55 % participation rate, 48 % female, primary tumor site: 28 % lung, 14 % prostate, 11 % breast). Clinically relevant levels of existential distress were present in 46.4 % (95 % CI, 41.7 % to 51.1 %), including demoralization, 12.5 % (95 % CI, 9.6 % to 15.9 %), death anxiety, 27.3 % (95 % CI, 23.2 % to 31.6 %), and dignity-related distress, 38.7 % (95 % CI, 34.2 % to 43.3 %). Frequent existential distress symptoms were sense of entrapment and fear of own and close others' suffering. Mental disorders occurred in 26.2 % (95 % CI, 22.2 % to 30.4 %), including major depression, 8.6 % (95 % CI, 6.2 % to 11.5 %), anxiety disorders, 8.4 % (95 % CI, 6.0 % to 11.3 %), and ICD-11-adjustment disorder, 10.5 % (95 % CI, 7.9 % to 13.7 %). Existential distress and mental disorders co-occurred in 20.0 % (95 % CI, 16.4 % to 24.0 %).</div></div><div><h3>Conclusion</h3><div>Existential distress is a common, clinically significant problem in patients with advanced cancer. Its recognition in multiprofessional clinical settings can contribute to improve quality of life. Most patients with a mental disorder show comorbid existential distress requiring treatment of both.</div></div>","PeriodicalId":12517,"journal":{"name":"General hospital psychiatry","volume":"94 ","pages":"Pages 184-191"},"PeriodicalIF":4.1,"publicationDate":"2025-03-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143644306","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}