{"title":"Association between allostatic load and cardiac structural and functional abnormalities in young adults with serious mental disorders.","authors":"Pao-Huan Chen, Cheng-Yi Hsiao, Jiunn-Kae Wang, Hsiao-Lun Ku, Kuo-Hsuan Chung, Shang-Ying Tsai","doi":"10.1016/j.genhosppsych.2024.12.011","DOIUrl":"https://doi.org/10.1016/j.genhosppsych.2024.12.011","url":null,"abstract":"<p><strong>Objective: </strong>Allostatic load refers to the pathophysiological consequences of uncompensated adaptation to chronic stress. Few studies have investigated the effect of allostatic load on cardiac health in patients with serious mental disorders (SMDs), a population at high risk of cardiac mortality. Herein we evaluated associations between allostatic load and cardiac structure and function in young adults with SMDs.</p><p><strong>Method: </strong>A total of 106 participants aged younger than 45 years underwent echocardiographic study, blood biochemistry examination, and blood cell count analysis. Echocardiographic imaging was conducted in accordance with recommendations of the American Society of Echocardiography and European Association of Cardiovascular Imaging. Allostatic load index was calculated using 15 measures representing cardiovascular, metabolic, and inflammatory or oxidative stress markers.</p><p><strong>Results: </strong>The SMD group exhibited a significantly higher allostatic load index than did control (Cohen's d = 0.59). Additionally, they exhibited a greater left ventricular relative wall thickness (LVRWT, Cohen's d = 0.39) and a less favorable mitral valve E/A ratio (Cohen's d = 0.31), left ventricular ejection fraction (Cohen's d = 0.51), and global longitudinal strain (Cohen's d = 0.71). After demographic and clinical characteristics were adjusted for, multiple linear regression revealed that allostatic load index was positively associated with LVRWT (β = 0.255) and negatively associated with mitral valve E/A ratio (β = -0.247) in the SMD group.</p><p><strong>Conclusions: </strong>This is the first study to suggest that allostatic load may play a critical role in accelerated adverse cardiac remodeling among young patients with SMDs. Future studies should elucidate the underlying mechanisms.</p>","PeriodicalId":12517,"journal":{"name":"General hospital psychiatry","volume":"92 ","pages":"40-45"},"PeriodicalIF":4.1,"publicationDate":"2024-12-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142871886","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Telehealth approaches for improving depression and anxiety among patients with chronic obstructive pulmonary disease: A systematic review and meta-analysis.","authors":"Yuwei Zhang, Yurou Zhao, Xiao Jiang, Huifang Xu, Wenqi Lü, Xin Yang, Jin Li, Weihong Kuang","doi":"10.1016/j.genhosppsych.2024.12.009","DOIUrl":"https://doi.org/10.1016/j.genhosppsych.2024.12.009","url":null,"abstract":"<p><strong>Objective: </strong>This study aimed to systematically review the efficacy of telehealth approaches in alleviating depressive and anxiety symptoms in patients with chronic obstructive pulmonary disease (COPD) using evidence from randomized controlled trials (RCTs).</p><p><strong>Methods: </strong>This systematic review and meta-analysis was conducted according to the Preferred Reporting Items for Systematic reviews and Meta-Analyses (PRISMA) checklist. Databases including PubMed, Embase, Web of Science, and the Cochrane Library were searched for RCTs from database inception to June 2024. All statistical analyses were performed using RevMan 5.3. The standard mean difference (SMD) was used to pool the fixed effects of continuous outcomes.</p><p><strong>Results: </strong>Seven RCTs comprising 1174 participants were included in this review. The pooled analysis demonstrated that, compared with the control group, telemonitoring significantly affected anxiety among patients with COPD (SMD = -0.12, 95 % confidence interval [CI]: [-0.24, -0.01], p = 0.04), whereas the effect on depression was not significant (SMD = -0.10, 95 % CI: [-0.22, 0.02], p = 0.09).</p><p><strong>Conclusion: </strong>Telemonitoring effectively reduced anxiety in patients with COPD but had no significant effect on depression. The relatively small number of studies suggests that this area of research is still developing. Additional high-quality, enriched, and more widely distributed intervention studies are needed to further assess the effectiveness of telehealth approaches on mental health among patients with COPD.</p>","PeriodicalId":12517,"journal":{"name":"General hospital psychiatry","volume":"92 ","pages":"28-35"},"PeriodicalIF":4.1,"publicationDate":"2024-12-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142846333","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Sharon Taub, Noa Menkes-Caspi, Tom Fruchtman-Steinbok, Shiri Kamhi-Nesher, Amir Krivoy
{"title":"Patients with severe mental illness in the general emergency department: Clinical characteristics, quality of care and challenges.","authors":"Sharon Taub, Noa Menkes-Caspi, Tom Fruchtman-Steinbok, Shiri Kamhi-Nesher, Amir Krivoy","doi":"10.1016/j.genhosppsych.2024.11.014","DOIUrl":"https://doi.org/10.1016/j.genhosppsych.2024.11.014","url":null,"abstract":"<p><strong>Background: </strong>Morbidity and mortality rates are notably higher among individuals with severe mental illnesses (SMI). People with SMI often have lower access to healthcare services, and the medical care they receive is known to be suboptimal. Consequently, treatment in an acute care setting rather than a community setting is more common. We aim to explore medical care in the emergency department (ED) for people with SMI compared to a control population.</p><p><strong>Methods: </strong>In this matched cohort study, data on all adult Clalit Health Services (CHS) members who were referred to the general ED during the years 2018-2021 were extracted. Patients with SMI (ICD-10 codes for schizophrenia, schizoaffective disorder, and bipolar disorder) were matched with a control group of ED patients without SMI in a 1:3 ratio. The two groups were compared regarding ED admission reasons, management, and outcomes.</p><p><strong>Results: </strong>The total sample (n = 92,848) included ED patients with SMI (n = 23,212) and without (n = 69,636). The most common ED admission reasons in both groups were pain, traumatic injury, and cardiac symptoms. Patients in the SMI group had higher rates of diagnosed diabetes mellitus and obstructive pulmonary disease. ED assessment, measured by resource allocation, was less comprehensive for patients with SMI who presented with subjective complaints such as pain and weakness, while it was comparable between patients with and without SMI for other main presenting complaints. Workup for patients with SMI lasted longer and necessitated hospitalization at higher rates for most admission reasons. Mortality during the study period was almost twice as high among the SMI group (5 % vs. 2.3 %, p < 0.001).</p><p><strong>Discussion: </strong>Our findings indicate higher rates of morbidity and treatment complexity among patients with SMI. As expected, the mortality rate was higher in this group. An alarming gap in resource allocation for ED assessment was observed when patients presented with subjective complaints. Enhanced awareness and integrated resources in primary care are required to improve the management and physical healthcare of patients with SMI.</p>","PeriodicalId":12517,"journal":{"name":"General hospital psychiatry","volume":"92 ","pages":"100-105"},"PeriodicalIF":4.1,"publicationDate":"2024-12-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142927006","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Yanzhi Li, Yan Chen, Yingchen Jiang, Wanxin Wang, Lan Guo, Beifang Fan, Yifeng Liu, Huimin Zhang, Xinyi Lin, Kayla M Teopiz, Roger S McIntyre, Ciyong Lu, Xue Han
{"title":"Associations of childhood trauma with remission and treatment response after 12 weeks of selective serotonin reuptake inhibitor treatment in patients with major depressive disorder.","authors":"Yanzhi Li, Yan Chen, Yingchen Jiang, Wanxin Wang, Lan Guo, Beifang Fan, Yifeng Liu, Huimin Zhang, Xinyi Lin, Kayla M Teopiz, Roger S McIntyre, Ciyong Lu, Xue Han","doi":"10.1016/j.genhosppsych.2024.12.002","DOIUrl":"https://doi.org/10.1016/j.genhosppsych.2024.12.002","url":null,"abstract":"<p><strong>Objective: </strong>To explore the associations of childhood trauma and its subtypes with remission and treatment response after 12 weeks of selective serotonin reuptake inhibitor (SSRI) treatment among patients with major depressive disorder (MDD).</p><p><strong>Methods: </strong>Data were from patients with MDD in the Depression Cohort in China. At baseline, the Childhood Trauma Questionnaire-Short Form was used to assess childhood trauma, including physical abuse, emotional abuse, sexual abuse, physical neglect, and emotional neglect. After 12 weeks of SSRI treatment, depressive symptoms were evaluated using the Patient Health Questionnaire-9 (PHQ-9). Remission was defined as a PHQ-9 score < 5, and response was defined as a ≥ 50 % decline in the PHQ-9 score from baseline.</p><p><strong>Results: </strong>The sample included 572 patients with MDD (mean [SD] age, 27.4 [7.2] years; 30.6 % male). After receiving 12 weeks of SSRI treatment, 32.2 % of patients achieved remission and 49.1 % of patients responded to treatment. After fully adjusting for confounders, patients with childhood trauma (OR, 0.55; 95 % CI, 0.36 to 0.84), physical abuse (OR, 0.43; 95 % CI, 0.23 to 0.79), emotional abuse (OR, 0.40; 95 % CI, 0.24 to 0.67), or sexual abuse (OR, 0.49; 95 % CI, 0.24 to 0.99) had a lower likelihood of remission, but those with physical neglect or emotional neglect did not. The response showed similar results.</p><p><strong>Conclusions: </strong>Among patients with MDD, childhood abuse (i.e., physical abuse, emotional abuse, and sexual abuse), but not childhood neglect (i.e., physical neglect and emotional neglect), was associated with a lower likelihood of remission and response after 12 weeks of SSRI treatment.</p>","PeriodicalId":12517,"journal":{"name":"General hospital psychiatry","volume":"92 ","pages":"12-19"},"PeriodicalIF":4.1,"publicationDate":"2024-12-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142812819","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}